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Aliases & Descriptions for GADD45GIP1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CKBBP2 1, 2 | | CRIF1 1, 2, 3 | | MGC4667 1, 2 | | MGC4758 1, 2 | | PLINP-1 1, 2, 3 | | PLINP1 3 | | PRG6 1, 2, 3, 5 | | Plinp1 1, 2 |
| | | Descriptions |
|---|
| CKII beta binding protein 2 2 | | CKII beta-associating protein 3 | | CR6 interacting factor 1 2 | | CR6-interacting factor 1 3 | | Papillomavirus L2-interacting nuclear protein 1 3 | growth arrest and DNA-damage-inducible, gamma interacting protein 1 2 | | p53-responsive gene 6 2 | | p53-responsive gene 6 protein 3 | | papillomavirus L2 interacting nuclear protein 1 2 |
|
| | Search outside databases for aliases for GADD45GIP1 genePrevious GC identifer: GC19M012926 |
Summaries for GADD45GIP1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: G45IP_HUMAN, Q8TAE8Function: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activityGene Wiki entry for GADD45GIP1 |
Genomic Location for GADD45GIP1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the GADD45GIP1 gene 
Entrez Gene cytogenetic band: 19p13.13 Ensembl cytogenetic band: 19p13.13 HGNC cytogenetic band: 19p13.2GADD45GIP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M012927:
(about GC identifiers)
Start:
|
12,925,972 bp from pter |
End:
|
12,929,050 bp from pter |
Size:
|
3,079 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011295.10
| Proteins for GADD45GIP1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: G45IP_HUMAN, Q8TAE8 (See
protein sequence)Recommended Name: Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Size: 222 amino acids; 25384 Da
Subunit: Interacts with GADD45A, GADD45B and GADD45G. Interacts with NR4A1 via the NR4A1 AB domain. Interacts with the human papilloma virus type 16 (HPV 16) minor capsid protein L2
Subcellular location: Nucleus
Miscellaneous: Cells overexpressing GADD45GIP1 were more likely to be in G1 and less likely to be in S phase and grow more slowly than control cells. Inhibiting the expression of GADD45GIP1 promotes cell cycle progression
Secondary accessions: Q8IVM3 Q8TE51 Q969P9 Q9BSM6Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_443082.2
ENSEMBL proteins: ENSP00000323065
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: GADD45GIP1 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for GADD45GIP1: Assays for GADD45GIP1: | Protein
Domains/ Families for GADD45GIP1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8TAE8
ProtoNet protein and cluster: Q8TAE8 | Gene Function for GADD45GIP1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_052850
Applied Biosystems Silencer® siRNAs for GADD45GIP1
Sigma-Aldrich siRNA for GADD45GIP1  Sigma-Aldrich shRNA for GADD45GIP1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_052850                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_052850                                  untagged cDNA clone in CMV expression vector: NM_052850 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_052850
UniProtKB/Swiss-Prot: G45IP_HUMAN, Q8TAE8Function: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activityInduction: Down-regulated by p53/TP53 in apopoptic cells1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for GADD45GIP1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/13 Interacting proteins for GADD45GIP1 (ENSP000003230653 Q8TAE81, 2) via UniProtKB, MINT, and/or STRING (see all 13
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007049 | cell cycle |
IEA | -- | | GO:0044419 | interspecies interaction between organisms |
IEA | -- | About this table
|
Drugs & Compounds for GADD45GIP1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for GADD45GIP1
|
Transcripts for GADD45GIP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_052850
Sigma-Aldrich siRNA for GADD45GIP1  Sigma-Aldrich shRNA for GADD45GIP1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_052850 REFSEQ mRNAs for GADD45GIP1 gene: NM_052850.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_052850               OriGene GFP tagged cDNA clone in CMV expression vector: NM_052850                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_052850                                  untagged cDNA clone in CMV expression vector: NM_052850  Additional cDNA sequence: AF412816.1 AF475095.1 AF479749.1 AJ295986.1 AJ429498.1 BC004944.1 BC013027.2 BC013039.2 BC069200.1 7 DOTS entries: DT.217955 DT.91912547 DT.97759885 DT.121481538 DT.95328208 DT.95328206 DT.121481567 24/299 AceView cDNA sequences (see all 299
):AW009704 AF475095 AI185240 BU682200 AI244617 AI356815 AI361663 AI128410 AI423524 AI096835 AI300029 BU540995 AW139878 AI334058 AW592583 AJ295986 CB048205 BQ083827 AI216175 BQ478251 AI207277 AW134893 AF147080 AI701371
highest scoring ESTs for GADD45GIP1:AA088470 AA088471 AA149617 AA161035 AA205393 AA286885 AA286886 AA488138 AA502910 AA503634 Unigene Cluster for GADD45GIP1: Growth arrest and DNA-damage-inducible, gamma interacting protein 1 Hs.515164 [show with all ESTs]Unigene Representative Sequence: BQ052504
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000316939
|
Expression for GADD45GIP1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| GADD45GIP1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for GADD45GIP1
1 / 2 / 3 2 probe-sets matching GADD45GIP1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCCAAGATGC
SOURCE GeneReport for Unigene cluster: Hs.515164 UniProtKB/Swiss-Prot: G45IP_HUMAN, Q8TAE8Tissue specificity: Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer |
Orthologs for GADD45GIP1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GADD45GIP1 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for GADD45GIP1
ENSEMBL Gene Tree for GADD45GIP1 | Paralogs for GADD45GIP1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for GADD45GIP1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
The following additional 28 SNP(s) have been
found in Applied Biosystems data source: (Click
for
Applied Biosystems TaqMan ® Genotyping Assay)
HapMap Linkage Disequilibrium images for GADD45GIP1 (up to first 250kb)
|
Disorders & Mutations for GADD45GIP1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605162
|
Medical News for GADD45GIP1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for GADD45GIP1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/12 PubMed articles for GADD45GIP1 gene (see all 12
):- Interaction of human papillomavirus type 16 L2 with cellular proteins: identification of novel nuclear body-associated proteins. (PubMed id 12482659)2, 3, 4 Gornemann J....Muller M. (2002)
- Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene. (PubMed id 10441517)2, 3, 4 Horikoshi N.... Shenk T. (1999)
- CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle. (PubMed id 12716909)1, 3, 4 Chung H.K.... Shong M. (2003)
- CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation. (PubMed id 15459248)1, 3, 4 Park K.C....Shong M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor. (PubMed id 17804717)1, 3 Nakayama K....Shih I.e.M. (2007)
- CR6-interacting factor 1 represses the transactivation of androgen receptor by direct interaction. (PubMed id 17885209)1, 3 Suh J.H....Lee K. (2008)
- Phosphorylation of CKBBP2/CRIF1 by protein kinase CKII promotes cell proliferation. (PubMed id 17069992)3 Oh N.S....Bae Y.S. (2007)
- A protein interaction framework for human mRNA degradation. (PubMed id 15231747)3 Lehner B. and Sanderson C.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for GADD45GIP1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing GADD45GIP1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing GADD45GIP1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GADD45GIP1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for GADD45GIP1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for GADD45GIP1:

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| Antibodies & Assays for GADD45GIP1  (GADD45 alpha/gamma) |
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Incremental update: 13 Oct 2009
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