GADD45GIP1 Gene
protein-coding GIFtS: 45
GCID: GC19M013065
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growth arrest and DNA-damage-inducible, gamma interacting...
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Aliases
for GADD45GIP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Growth Arrest And DNA-Damage-Inducible, Gamma Interacting Protein 11 2 | | MGC47581 | | PRG61 2 3 5 | | CKII Beta Binding Protein 22 | | CRIF11 2 3 | | CR6 Interacting Factor 12 | | PLINP-11 2 3 | | Growth Arrest And DNA Damage-Inducible Proteins-Interacting Protein 12 | | CKBBP21 2 | | Growth Arrest- And DNA Damage-Inducible GADD45G-Interacting Protein2 | | Plinp11 2 | | Papillomavirus L2 Interacting Nuclear Protein 12 | | PLINP2 3 | | PLINP13 | | CKII Beta-Associating Protein2 3 | | CR6-Interacting Factor 13 | | P53-Responsive Gene 6 Protein2 3 | | Papillomavirus L2-Interacting Nuclear Protein 13 | | MGC46671 | | |
Export aliases for GADD45GIP1 gene to outside databasesPrevious GC identifers: GC19M012926 GC19M012927 GC19M012637 |
Summaries
for GADD45GIP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GADD45GIP1:
This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1to S phase progression. The encoded protein may interact with other cell cycle regulators. (provided by RefSeq, Aug2012)
UniProtKB/Swiss-Prot: G45IP_HUMAN, Q8TAE8Function: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases.Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as arepressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May beinvolved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrialprotein synthesis
Gene Wiki entry for GADD45GIP1
|
Genomic Views
for GADD45GIP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GADD45GIP1 gene promoter:
p53 Lmo2 STAT5A Ik-3 Tal-1beta SEF-1 (1) NF-kappaB1 ITF-2 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for GADD45GIP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GADD45GIP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2GADD45GIP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M013065: view genomic region
(about GC identifiers)
Start:
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13,064,972 bp from pter |
End:
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13,068,050 bp from pter |
Size:
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3,079 bases |
Orientation:
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minus strand |
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Proteins
for GADD45GIP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: G45IP_HUMAN, Q8TAE8 (See
protein sequence)Recommended Name: Growth arrest and DNA damage-inducible proteins-interacting protein 1 Size: 222 amino acids; 25384 Da
Subunit: Interacts with GADD45A, GADD45B and GADD45G. Interacts with NR4A1 via the NR4A1 AB domain. Interacts with thehuman papilloma virus type 16 (HPV 16) minor capsid protein L2. Interacts with ATAD3A and ATAD3B
Subcellular location: Mitochondrion. Nucleus. Note=Using N-terminally tagged constructs, has been found in the nucleus(PubMed:12482659). C-terminally tagged constructs are targeted exclusively to mitochondria (PubMed:22453275). Thisdiscrepancy may be explained by masking of a potential N-terminal mitochondrial targeting signal by the tag(PubMed:22453275)
Miscellaneous: Cells overexpressing GADD45GIP1 were more likely to be in G1 and less likely to be in S phase and growmore slowly than control cells. Inhibiting the expression of GADD45GIP1 promotes cell cycle progression
Secondary accessions: Q8IVM3 Q8TE51 Q969P9 Q9BSM6Explore the universe of human proteins at neXtProt for GADD45GIP1: NX_Q8TAE8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TAE8
GADD45GIP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_443082.2
ENSEMBL proteins: ENSP00000323065
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
GADD45GIP1 for ontologies About GeneDecksing
GADD45GIP1 Antibody Products:
Assay Products for GADD45GIP1: |
Protein
Domains /
Families
for GADD45GIP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GADD45GIP1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TAE8ProtoNet protein and cluster: Q8TAE8 |
Function
for GADD45GIP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: G45IP_HUMAN, Q8TAE8Function: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases.Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as arepressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May beinvolved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrialprotein synthesisInduction: Down-regulated by p53/TP53 in apoptotic cells
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GADD45GIP1
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
GADD45GIP1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Gadd45gip1tm1Kong for GADD45GIP1
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Gadd45gip1):
GADD45GIP1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for GADD45GIP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GADD45GIP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/247 Interacting proteins for GADD45GIP1 (Q8TAE81, 2, 3 ENSP000003230654) via UniProtKB, MINT, STRING, and/or I2D (see all 247)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| GADD45G | O952571, 2, 3, ENSP000002525064 | EBI-372506,EBI-5773903 MINT-17694 MINT-17693 I2D:
score=5 STRING: ENSP00000252506 | | STAT3 | P407632, 3, ENSP000002646574 | MINT-6492422 MINT-6492551 MINT-6492512 MINT-6492537 I2D:
score=1 STRING: ENSP00000264657 | | GADD45B | O752932, 3, ENSP000002156314 | MINT-14285 MINT-14286 I2D:
score=4 STRING: ENSP00000215631 | | GADD45A | P245221, 2, 3, ENSP000003600254 | EBI-372506,EBI-448167 MINT-16447 MINT-16448 MINT-16446 I2D:
score=5 STRING: ENSP00000360025 | | ICT1 | Q141972, 3, ENSP000003015854 | MINT-8079030 I2D:
score=1 STRING: ENSP00000301585 |
About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007049 | cell cycle |
IEA | -- | | GO:0019048 | virus-host interaction |
IEA | -- | | GO:0044419 | interspecies interaction between organisms |
-- | -- |
GADD45GIP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for GADD45GIP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GADD45GIP1
Search CenterWatch for drugs/clinical trials and news about GADD45GIP1 / G45IP
|
Transcripts
for GADD45GIP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GADD45GIP1 gene: NM_052850.3 Unigene Cluster for GADD45GIP1: Growth arrest and DNA-damage-inducible, gamma interacting protein 1 Hs.515164 [show with all ESTs]Unigene Representative Sequence: BQ0525041 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000316939(uc002mwb.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GADD45GIP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GADD45GIP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GADD45GIP1 (NM_052850) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GADD45GIP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GADD45GIP1 |
Additional cDNA sequence: AF412816.1 AF475095.1 AF479749.1 AJ295986.1 AJ429498.1 BC004944.1 BC013027.2 BC013039.2 BC069200.1 7 DOTS entries: DT.217955 DT.91912547 DT.97759885 DT.121481538 DT.95328208 DT.95328206 DT.121481567 24/299 AceView cDNA sequences (see all 299): AI207277 BE255254 AI139187 BQ083827 AW134893 AI148606 AW139878 BE645692 AI306505 AI096835 AW054807 AI185240 BE266447 AJ295986 BQ478251 BU859910 AI281957 BC013039 AW016917 AW205020 BE263477 AI222982 AI401098 BC013027
GeneLoc Exon Structure
|
Expression
for GADD45GIP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GADD45GIP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCAAGATGC
About this image
See GADD45GIP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GADD45GIP1
SOURCE GeneReport for Unigene cluster: Hs.515164
UniProtKB/Swiss-Prot: G45IP_HUMAN, Q8TAE8Tissue specificity: Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenaltissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barelydetectable in adrenal adenoma and papillary thyroid cancer
SABiosciences Custom PCR Arrays for GADD45GIP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GADD45GIP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GADD45GIP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GADD45GIP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GADD45GIP1 |
Orthologs
for GADD45GIP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for GADD45GIP1 gene from 5/14 species (see all 14) About this table
ENSEMBL Gene Tree for GADD45GIP1 (if available)
TreeFam Gene Tree for GADD45GIP1 (if available) |
Paralogs
for GADD45GIP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for GADD45GIP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GADD45GIP1 (13064972 - 13068050 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GADD45GIP1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GADD45GIP1 |
|
Disorders
/ Diseases
for GADD45GIP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GADD45GIP1 for disorders About GeneDecksing
OMIM gene information: 605162
OMIM disorders: --
5  diseases for GADD45GIP1: About MalaCardsadrenal adenoma adenoma thyroid cancer thyroiditis
ovarian cancer
Export disorders for GADD45GIP1 gene to outside databases
|
Publications
for GADD45GIP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GADD45GIP1 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with GADD45GIP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Interaction of human papillomavirus type 16 L2 with cellular proteins: identification of novel nuclear body-associated proteins. (PubMed id 12482659)1, 2, 3 Goernemann J.... Mueller M. (2002)
- Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene. (PubMed id 10441517)1, 2, 3 Horikoshi N.... Shenk T. (1999)
- CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle. (PubMed id 12716909)1, 2, 9 Chung H.K.... Shong M. (2003)
- CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation. (PubMed id 15459248)1, 2, 9 Park K.C....Shong M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor. (PubMed id 17804717)1, 9 Nakayama K....Shih I.e.M. (2007)
- CR6-interacting factor 1 represses the transactivation of androgen receptor by direct interaction. (PubMed id 17885209)1, 9 Suh J.H....Lee K. (2008)
- Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis. (PubMed id 22453275)2 He J....Holt I.J. (2012)
- DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation. (PubMed id 22446626)1 Close P.... Svejstrup J.Q. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
|
External Searches for GADD45GIP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GADD45GIP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GADD45GIP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GADD45GIP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for GADD45GIP1 gene:
Search GeneIP for patents involving GADD45GIP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GADD45GIP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for GADD45GIP1 | | OriGene Custom Protein Services for GADD45GIP1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GADD45GIP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GADD45GIP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GADD45GIP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GADD45GIP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GADD45GIP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GADD45GIP1 |
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