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Aliases for GADD45GIP1 Gene

Aliases for GADD45GIP1 Gene

  • GADD45G Interacting Protein 1 2 3 5
  • Growth Arrest And DNA-Damage-Inducible, Gamma Interacting Protein 1 2 3
  • Papillomavirus L2 Interacting Nuclear Protein 1 2 3
  • 39S Ribosomal Protein L59, Mitochondrial 3 4
  • CKII Beta-Associating Protein 3 4
  • P53-Responsive Gene 6 Protein 3 4
  • CKII Beta Binding Protein 2 2 3
  • CR6 Interacting Factor 1 2 3
  • MRP-L59 3 4
  • PLINP-1 3 4
  • Plinp1 3 4
  • CRIF1 3 4
  • PLINP 3 4
  • PRG6 3 4
  • Growth Arrest- And DNA Damage-Inducible GADD45G-Interacting Protein 3
  • Papillomavirus L2-Interacting Nuclear Protein 1 4
  • CR6-Interacting Factor 1 4
  • P53-Responsive Gene 6 2
  • CKbetaBP2 3
  • CKBBP2 3
  • MRPL59 4

External Ids for GADD45GIP1 Gene

Previous GeneCards Identifiers for GADD45GIP1 Gene

  • GC19M012926
  • GC19M012927
  • GC19M013065
  • GC19M012637

Summaries for GADD45GIP1 Gene

Entrez Gene Summary for GADD45GIP1 Gene

  • This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators. [provided by RefSeq, Aug 2012]

GeneCards Summary for GADD45GIP1 Gene

GADD45GIP1 (GADD45G Interacting Protein 1) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation.

UniProtKB/Swiss-Prot for GADD45GIP1 Gene

  • Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.

Gene Wiki entry for GADD45GIP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GADD45GIP1 Gene

Genomics for GADD45GIP1 Gene

Regulatory Elements for GADD45GIP1 Gene

Promoters for GADD45GIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GADD45GIP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GADD45GIP1 Gene

Chromosome:
19
Start:
12,953,119 bp from pter
End:
12,957,254 bp from pter
Size:
4,136 bases
Orientation:
Minus strand

Genomic View for GADD45GIP1 Gene

Genes around GADD45GIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GADD45GIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GADD45GIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GADD45GIP1 Gene

Proteins for GADD45GIP1 Gene

  • Protein details for GADD45GIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAE8-G45IP_HUMAN
    Recommended name:
    Growth arrest and DNA damage-inducible proteins-interacting protein 1
    Protein Accession:
    Q8TAE8
    Secondary Accessions:
    • Q8IVM3
    • Q8TE51
    • Q969P9
    • Q9BSM6

    Protein attributes for GADD45GIP1 Gene

    Size:
    222 amino acids
    Molecular mass:
    25384 Da
    Quaternary structure:
    • Interacts with GADD45A, GADD45B and GADD45G. Interacts with NR4A1 via the NR4A1 AB domain. Interacts with the human papilloma virus type 16 (HPV 16) minor capsid protein L2. Interacts with ATAD3A and ATAD3B. Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
    Miscellaneous:
    • Cells overexpressing GADD45GIP1 were more likely to be in G1 and less likely to be in S phase and grow more slowly than control cells. Inhibiting the expression of GADD45GIP1 promotes cell cycle progression.

    Three dimensional structures from OCA and Proteopedia for GADD45GIP1 Gene

neXtProt entry for GADD45GIP1 Gene

Proteomics data for GADD45GIP1 Gene at MOPED

Post-translational modifications for GADD45GIP1 Gene

  • Ubiquitination at Lys 59, Lys 127, and Lys 184
  • Modification sites at PhosphoSitePlus

Other Protein References for GADD45GIP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GADD45GIP1 Gene

Domains & Families for GADD45GIP1 Gene

Protein Domains for GADD45GIP1 Gene

Suggested Antigen Peptide Sequences for GADD45GIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GADD45GIP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GADD45GIP1 Gene

Function for GADD45GIP1 Gene

Molecular function for GADD45GIP1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
UniProtKB/Swiss-Prot Induction:
Down-regulated by p53/TP53 in apoptotic cells.
genes like me logo Genes that share phenotypes with GADD45GIP1: view

Animal Models for GADD45GIP1 Gene

MGI Knock Outs for GADD45GIP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GADD45GIP1 Gene

Localization for GADD45GIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GADD45GIP1 Gene

Mitochondrion. Nucleus. Note=Using N-terminally tagged constructs, has been found in the nucleus (PubMed:12482659). C-terminally tagged constructs are targeted exclusively to mitochondria (PubMed:22453275). This discrepancy may be explained by masking of a potential N-terminal mitochondrial targeting signal by the tag (PubMed:22453275). {ECO:0000269 PubMed:12482659, ECO:0000269 PubMed:22453275}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GADD45GIP1 Gene COMPARTMENTS Subcellular localization image for GADD45GIP1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for GADD45GIP1 Gene

Pathways & Interactions for GADD45GIP1 Gene

genes like me logo Genes that share pathways with GADD45GIP1: view

Gene Ontology (GO) - Biological Process for GADD45GIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0016032 viral process IEA --
GO:0032543 mitochondrial translation TAS --
genes like me logo Genes that share ontologies with GADD45GIP1: view

No data available for SIGNOR curated interactions for GADD45GIP1 Gene

Drugs & Compounds for GADD45GIP1 Gene

No Compound Related Data Available

Transcripts for GADD45GIP1 Gene

mRNA/cDNA for GADD45GIP1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(299) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GADD45GIP1 Gene

Growth arrest and DNA-damage-inducible, gamma interacting protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GADD45GIP1 Gene

No ASD Table

Relevant External Links for GADD45GIP1 Gene

GeneLoc Exon Structure for
GADD45GIP1
ECgene alternative splicing isoforms for
GADD45GIP1

Expression for GADD45GIP1 Gene

mRNA expression in normal human tissues for GADD45GIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GADD45GIP1 Gene

This gene is overexpressed in Lung (26.6), Heart (14.8), and Peripheral blood mononuclear cells (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GADD45GIP1 Gene



SOURCE GeneReport for Unigene cluster for GADD45GIP1 Gene Hs.515164

mRNA Expression by UniProt/SwissProt for GADD45GIP1 Gene

Q8TAE8-G45IP_HUMAN
Tissue specificity: Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer.
genes like me logo Genes that share expression patterns with GADD45GIP1: view

Protein tissue co-expression partners for GADD45GIP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for GADD45GIP1 Gene

Orthologs for GADD45GIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GADD45GIP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GADD45GIP1 35
  • 83.78 (n)
  • 81.08 (a)
GADD45GIP1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GADD45GIP1 35
  • 86.3 (n)
  • 81.28 (a)
GADD45GIP1 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gadd45gip1 35
  • 76.43 (n)
  • 73.87 (a)
Gadd45gip1 16
Gadd45gip1 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GADD45GIP1 35
  • 99.25 (n)
  • 98.2 (a)
GADD45GIP1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gadd45gip1 35
  • 77.37 (n)
  • 75.79 (a)
oppossum
(Monodelphis domestica)
Mammalia GADD45GIP1 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GADD45GIP1 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gadd45gip1 35
  • 60.05 (n)
  • 45.89 (a)
zebrafish
(Danio rerio)
Actinopterygii gadd45gip1 35
  • 59.39 (n)
  • 47.18 (a)
gadd45gip1 36
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToOne
Species with no ortholog for GADD45GIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GADD45GIP1 Gene

ENSEMBL:
Gene Tree for GADD45GIP1 (if available)
TreeFam:
Gene Tree for GADD45GIP1 (if available)

Paralogs for GADD45GIP1 Gene

No data available for Paralogs for GADD45GIP1 Gene

Variants for GADD45GIP1 Gene

Sequence variations from dbSNP and Humsavar for GADD45GIP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2965218 -- 12,958,584(-) CTATC(G/T)CAAGG upstream-variant-2KB
rs10420635 -- 12,959,197(+) gggtg(C/T)ggtgg upstream-variant-2KB
rs11538996 -- 12,954,348(-) TCCAG(G/T)AGCTG reference, stop-gained
rs12151206 -- 12,955,505(+) TAAAC(A/C)CCAGG intron-variant
rs55981416 -- 12,958,698(+) TATAC(A/T)TTTAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GADD45GIP1 Gene

Variant ID Type Subtype PubMed ID
nsv911082 CNV Loss 21882294
nsv833754 CNV Loss 17160897
nsv911085 CNV Loss 21882294

Variation tolerance for GADD45GIP1 Gene

Residual Variation Intolerance Score: 90.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 46.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GADD45GIP1 Gene

HapMap Linkage Disequilibrium report
GADD45GIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GADD45GIP1 Gene

Disorders for GADD45GIP1 Gene

Relevant External Links for GADD45GIP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GADD45GIP1

No disorders were found for GADD45GIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GADD45GIP1 Gene

Publications for GADD45GIP1 Gene

  1. Interaction of human papillomavirus type 16 L2 with cellular proteins: identification of novel nuclear body-associated proteins. (PMID: 12482659) Goernemann J. … Mueller M. (Virology 2002) 2 3 4 67
  2. CR6-interacting factor 1 represses the transactivation of androgen receptor by direct interaction. (PMID: 17885209) Suh J.H. … Lee K. (Mol. Endocrinol. 2008) 3 23
  3. Crif1 is a novel transcriptional coactivator of STAT3. (PMID: 18200042) Kwon M.C. … Kong Y.Y. (EMBO J. 2008) 3 23
  4. NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor. (PMID: 17804717) Nakayama K. … Shih I.-M. (Cancer Res. 2007) 3 23
  5. CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation. (PMID: 15459248) Park K.C. … Shong M. (Mol. Endocrinol. 2005) 3 23

Products for GADD45GIP1 Gene

Sources for GADD45GIP1 Gene

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