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Aliases for GADD45GIP1 Gene

Aliases for GADD45GIP1 Gene

  • Growth Arrest And DNA-Damage-Inducible, Gamma Interacting Protein 1 2 3
  • PRG6 3 4 6
  • Papillomavirus L2 Interacting Nuclear Protein 1 2 3
  • 39S Ribosomal Protein L59, Mitochondrial 3 4
  • CKII Beta-Associating Protein 3 4
  • P53-Responsive Gene 6 Protein 3 4
  • CKII Beta Binding Protein 2 2 3
  • CR6 Interacting Factor 1 2 3
  • MRP-L59 3 4
  • PLINP-1 3 4
  • Plinp1 3 4
  • CRIF1 3 4
  • PLINP 3 4
  • Growth Arrest And DNA Damage-Inducible Proteins-Interacting Protein 1 3
  • Growth Arrest- And DNA Damage-Inducible GADD45G-Interacting Protein 3
  • Papillomavirus L2-Interacting Nuclear Protein 1 4
  • CR6-Interacting Factor 1 4
  • P53-Responsive Gene 6 2
  • CKbetaBP2 3
  • CKBBP2 3
  • MRPL59 4

External Ids for GADD45GIP1 Gene

Summaries for GADD45GIP1 Gene

Entrez Gene Summary for GADD45GIP1 Gene

  • This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators. [provided by RefSeq, Aug 2012]

GeneCards Summary for GADD45GIP1 Gene

GADD45GIP1 (Growth Arrest And DNA-Damage-Inducible, Gamma Interacting Protein 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for GADD45GIP1 Gene

  • Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis

Gene Wiki entry for GADD45GIP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GADD45GIP1 Gene

Genomics for GADD45GIP1 Gene

Genomic Location for GADD45GIP1 Gene

Start:
12,953,119 bp from pter
End:
12,957,254 bp from pter
Size:
4,136 bases
Orientation:
Minus strand

Genomic View for GADD45GIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GADD45GIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GADD45GIP1 Gene

Regulatory Elements for GADD45GIP1 Gene

Proteins for GADD45GIP1 Gene

  • Protein details for GADD45GIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAE8-G45IP_HUMAN
    Recommended name:
    Growth arrest and DNA damage-inducible proteins-interacting protein 1
    Protein Accession:
    Q8TAE8
    Secondary Accessions:
    • Q8IVM3
    • Q8TE51
    • Q969P9
    • Q9BSM6

    Protein attributes for GADD45GIP1 Gene

    Size:
    222 amino acids
    Molecular mass:
    25384 Da
    Quaternary structure:
    • Interacts with GADD45A, GADD45B and GADD45G. Interacts with NR4A1 via the NR4A1 AB domain. Interacts with the human papilloma virus type 16 (HPV 16) minor capsid protein L2. Interacts with ATAD3A and ATAD3B. Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
    Miscellaneous:
    • Cells overexpressing GADD45GIP1 were more likely to be in G1 and less likely to be in S phase and grow more slowly than control cells. Inhibiting the expression of GADD45GIP1 promotes cell cycle progression

    Three dimensional structures from OCA and Proteopedia for GADD45GIP1 Gene

neXtProt entry for GADD45GIP1 Gene

Proteomics data for GADD45GIP1 Gene at MOPED

Post-translational modifications for GADD45GIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys59, Lys127, Lys184, and Lys185

Other Protein References for GADD45GIP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GADD45GIP1 Gene

Domains for GADD45GIP1 Gene

Protein Domains for GADD45GIP1 Gene

genes like me logo Genes that share domains with GADD45GIP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GADD45GIP1 Gene

Function for GADD45GIP1 Gene

Molecular function for GADD45GIP1 Gene

UniProtKB/Swiss-Prot Function: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis
UniProtKB/Swiss-Prot Induction: Down-regulated by p53/TP53 in apoptotic cells.

Gene Ontology (GO) - Molecular Function for GADD45GIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12716909
genes like me logo Genes that share ontologies with GADD45GIP1: view
genes like me logo Genes that share phenotypes with GADD45GIP1: view

Animal Models for GADD45GIP1 Gene

MGI Knock Outs for GADD45GIP1:

miRNA for GADD45GIP1 Gene

miRTarBase miRNAs that target GADD45GIP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GADD45GIP1 Gene

Localization for GADD45GIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GADD45GIP1 Gene

Mitochondrion. Nucleus. Note=Using N-terminally tagged constructs, has been found in the nucleus (PubMed:12482659). C-terminally tagged constructs are targeted exclusively to mitochondria (PubMed:22453275). This discrepancy may be explained by masking of a potential N-terminal mitochondrial targeting signal by the tag (PubMed:22453275). {ECO:0000269 PubMed:12482659, ECO:0000269 PubMed:22453275}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GADD45GIP1 Gene COMPARTMENTS Subcellular localization image for GADD45GIP1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
extracellular 1

Gene Ontology (GO) - Cellular Components for GADD45GIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IDA --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with GADD45GIP1: view

Pathways for GADD45GIP1 Gene

SuperPathways for GADD45GIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GADD45GIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0007049 cell cycle --
GO:0016032 viral process IEA --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with GADD45GIP1: view

No data available for Pathways by source for GADD45GIP1 Gene

Transcripts for GADD45GIP1 Gene

mRNA/cDNA for GADD45GIP1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(299) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GADD45GIP1 Gene

Growth arrest and DNA-damage-inducible, gamma interacting protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GADD45GIP1 Gene

No ASD Table

Relevant External Links for GADD45GIP1 Gene

GeneLoc Exon Structure for
GADD45GIP1
ECgene alternative splicing isoforms for
GADD45GIP1

Expression for GADD45GIP1 Gene

mRNA expression in normal human tissues for GADD45GIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GADD45GIP1 Gene

SOURCE GeneReport for Unigene cluster for GADD45GIP1 Gene Hs.515164

mRNA Expression by UniProt/SwissProt for GADD45GIP1 Gene

Q8TAE8-G45IP_HUMAN
Tissue specificity: Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer.
genes like me logo Genes that share expressions with GADD45GIP1: view

Orthologs for GADD45GIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GADD45GIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GADD45GIP1 36
  • 99.25 (n)
  • 98.2 (a)
GADD45GIP1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GADD45GIP1 36
  • 83.78 (n)
  • 81.08 (a)
GADD45GIP1 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GADD45GIP1 36
  • 86.3 (n)
  • 81.28 (a)
GADD45GIP1 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gadd45gip1 36
  • 76.43 (n)
  • 73.87 (a)
Gadd45gip1 16
Gadd45gip1 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GADD45GIP1 37
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gadd45gip1 36
  • 77.37 (n)
  • 75.79 (a)
lizard
(Anolis carolinensis)
Reptilia GADD45GIP1 37
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gadd45gip1 36
  • 60.05 (n)
  • 45.89 (a)
zebrafish
(Danio rerio)
Actinopterygii gadd45gip1 36
  • 59.39 (n)
  • 47.18 (a)
gadd45gip1 37
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 23 (a)
OneToOne
Species with no ortholog for GADD45GIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GADD45GIP1 Gene

ENSEMBL:
Gene Tree for GADD45GIP1 (if available)
TreeFam:
Gene Tree for GADD45GIP1 (if available)

Paralogs for GADD45GIP1 Gene

No data available for Paralogs for GADD45GIP1 Gene

Variants for GADD45GIP1 Gene

Sequence variations from dbSNP and Humsavar for GADD45GIP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2965218 -- 12,958,584(-) CTATC(G/T)CAAGG upstream-variant-2KB
rs10420635 -- 12,959,197(+) gggtg(C/T)ggtgg upstream-variant-2KB
rs11538996 -- 12,954,348(-) TCCAG(G/T)AGCTG reference, stop-gained
rs12151206 -- 12,955,505(+) TAAAC(A/C)CCAGG intron-variant
rs55981416 -- 12,958,698(+) TATAC(A/T)TTTAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GADD45GIP1 Gene

Variant ID Type Subtype PubMed ID
nsv911082 CNV Loss 21882294
nsv833754 CNV Loss 17160897
nsv911085 CNV Loss 21882294

Relevant External Links for GADD45GIP1 Gene

HapMap Linkage Disequilibrium report
GADD45GIP1

Disorders for GADD45GIP1 Gene

No disorders were found for GADD45GIP1 Gene.

No data available for UniProtKB/Swiss-Prot for GADD45GIP1 Gene

Publications for GADD45GIP1 Gene

  1. CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle. (PMID: 12716909) Chung H.K. … Shong M. (J. Biol. Chem. 2003) 3 4 23
  2. CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation. (PMID: 15459248) Park K.C. … Shong M. (Mol. Endocrinol. 2005) 3 4 23
  3. Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene. (PMID: 10441517) Horikoshi N. … Shenk T. (Biochem. Biophys. Res. Commun. 1999) 2 3 4
  4. Interaction of human papillomavirus type 16 L2 with cellular proteins: identification of novel nuclear body-associated proteins. (PMID: 12482659) Goernemann J. … Mueller M. (Virology 2002) 2 3 4
  5. NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor. (PMID: 17804717) Nakayama K. … Shih I.-M. (Cancer Res. 2007) 3 23

Products for GADD45GIP1 Gene

Sources for GADD45GIP1 Gene

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