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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GADD45G Gene

protein-coding   GIFtS: 63
GCID: GC09P092219

Growth Arrest And DNA-Damage-Inducible, Gamma

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Growth Arrest And DNA-Damage-Inducible, Gamma1 2     17 KD1
Cytokine-Responsive Protein CR62 3     Gadd-Related Protein1
CR62 3     Growth Arrest And DNA-Damage-Inducible Gamma1
DDIT-22 3     GADD45-gamma2
DDIT22 3     GADD45gamma2
DNA Damage-Inducible Transcript 2 Protein2 3     Gadd-Related Protein, 17 KD2
GRP172 5     Growth Arrest And DNA Damage-Inducible Protein GADD45 Gamma2

External Ids:    HGNC: 40971   Entrez Gene: 109122   Ensembl: ENSG000001302227   OMIM: 6049495   UniProtKB: O952573   

Export aliases for GADD45G gene to outside databases

Previous GC identifers: GC09P083195 GC09P084099 GC09P085804 GC09P087711 GC09P089449 GC09P091409 GC09P062051


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GADD45G Gene:
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest
conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental
stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in
placenta. (provided by RefSeq, Jul 2008)

GeneCards Summary for GADD45G Gene: 
GADD45G (growth arrest and DNA-damage-inducible, gamma) is a protein-coding gene. Diseases associated with GADD45G include thyroid cancer, and pituitary adenoma, and among its related super-pathways are DNA damage response and Immune response IL-12-induced IFN-gamma production. GO annotations related to this gene include protein binding. An important paralog of this gene is GADD45B.

UniProtKB/Swiss-Prot: GA45G_HUMAN, O95257
Function: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4
MAPKKK

Gene Wiki entry for GADD45G Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GADD45G gene promoter:
         GR   Pax-5   HOXA3   p53   CUTL1   NF-AT   C/EBPalpha   GR-alpha   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GADD45G promoter sequence
   Search SABiosciences Chromatin IP Primers for GADD45G

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GADD45G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.1-q22.2   Ensembl cytogenetic band:  9q22.2   HGNC cytogenetic band: 9q22.1-q22.2

GADD45G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GADD45G gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P092219:  view genomic region     (about GC identifiers)

Start:
92,219,927 bp from pter      End:
92,221,470 bp from pter
Size:
1,544 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GA45G_HUMAN, O95257 (See protein sequence)
Recommended Name: Growth arrest and DNA damage-inducible protein GADD45 gamma  
Size: 159 amino acids; 17121 Da
Subunit: Interacts with GADD45GIP1
2 PDB 3D structures from and Proteopedia for GADD45G:
2WAL (3D)        3FFM (3D)    
Secondary accessions: Q9C076

Explore the universe of human proteins at neXtProt for GADD45G: NX_O95257

Explore proteomics data for GADD45G at MOPED 

GADD45G Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

GADD45G Protein Expression

REFSEQ proteins: NP_006696.1  
ENSEMBL proteins: 
 ENSP00000252506   ENSP00000364924  

Human Recombinant Protein Products for GADD45G: 
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Novus Biologicals GADD45G Proteins
Novus Biologicals GADD45G Lysates
Sino Biological Recombinant Protein for GADD45G
Browse Sino Biological Cell Lysates 
ProSpec Recombinant Protein for GADD45G
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

GADD45G for ontologies           About GeneDecksing



GADD45G Antibody Products: 
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LSBio Antibodies in human, mouse, rat for GADD45G 

Assay Products for GADD45G: 
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Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
2 InterPro protein domains:
 IPR024824 GADD45
 IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45

Graphical View of Domain Structure for InterPro Entry O95257

ProtoNet protein and cluster: O95257

1 Blocks protein domain: IPB004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45

UniProtKB/Swiss-Prot: GA45G_HUMAN, O95257
Similarity: Belongs to the GADD45 family


GADD45G for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: GA45G_HUMAN, O95257
Function: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4
MAPKKK

     Genatlas biochemistry entry for GADD45G:
growth arrest and DNA-damage inducible,gamma,involved in negative control of cell growth

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI12716909
     
GADD45G for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for GADD45G:
 Increased HPV18 LCR reporter a 

     6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Gadd45g):
 cellular  endocrine/exocrine gland  hematopoietic system  immune system  renal/urinary system 
 reproductive system 

GADD45G for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for GADD45G: Gadd45gtm1Flv Gadd45gtm1Mhol Gadd45gtm1Jni

   inGenious Targeting Laboratory - Custom generated mouse model solutions for GADD45G 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GADD45G

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GADD45G 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GADD45G 

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GADD45G
4 QIAGEN miScript miRNA Assays for microRNAs that regulate GADD45G:
hsa-miR-383 hsa-miR-1468 hsa-miR-4297 hsa-miR-330-3p
SwitchGear 3'UTR luciferase reporter plasmidGADD45G 3' UTR sequence
Inhib. RNA
Products:
    
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Gene Editing
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Clone
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GADD45G
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                     Customized lentivirus expression plasmids for stable overexpression of GADD45G 

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GADD45G


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for GADD45G About   (see all 11)                                                                                              See pathways by source

SuperPathContained pathways About
1p53 signaling pathway
DNA damage response0.41
p53 signaling pathway0.41
2Immune response IL-12-induced IFN-gamma production
Immune response IL-12-induced IFN-gamma production0.88
IL12-mediated signaling events0.33
3Cell cycle
Cell cycle0.59
4MAPK signaling pathway
MAPK signaling pathway0.50
5p53 Pathway
p53 Signaling0.38

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 EMD Millipore Pathways for GADD45G
    Selected targets of Oct-3/4
Immune response IL-12-induced IFN-gamma production

5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GADD45G
    ATM Pathway
BRCA1 Pathway
DNA Repair Mechanisms
p53 Signaling
GADD45 Pathway

1 GeneGo (Thomson Reuters) Pathway for GADD45G
    Immune response IL-12-induced IFN-gamma production

3 BioSystems Pathways for GADD45G
    DNA damage response
p38 MAPK signaling pathway
IL12-mediated signaling events



3         Kegg Pathways  (Kegg details for GADD45G):
    MAPK signaling pathway
Cell cycle
p53 signaling pathway


GADD45G for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GADD45G

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/86 Interacting proteins for GADD45G (O952571, 2, 3 ENSP000002525064) via UniProtKB, MINT, STRING, and/or I2D (see all 86)
InteractantInteraction Details
GeneCardExternal ID(s)
GADD45GIP1Q8TAE81, 2, 3, ENSP000003230654EBI-448202,EBI-372506 MINT-17694 MINT-17693 I2D: score=5 STRING: ENSP00000323065
KIAA1377Q9P2H01, 2, 3, ENSP000002634684EBI-448202,EBI-473176 MINT-3981610 MINT-3979313 I2D: score=2 STRING: ENSP00000263468
DDAH2O958652, 3MINT-8256162 I2D: score=2 
ENSG00000206395O958652, 3MINT-8256162 I2D: score=2 
ENSG00000225635O958652, 3MINT-8256162 I2D: score=2 
About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000185activation of MAPKKK activity TAS9827804
GO:0000186activation of MAPKK activity IEA--
GO:0006281DNA repair TAS9827804
GO:0006469negative regulation of protein kinase activity IEA--
GO:0006915apoptotic process IEA--

GADD45G for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GADD45G (GA45G)

Search CenterWatch for drugs/clinical trials and news about GADD45G / GA45G

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GADD45G gene: 
NM_006705.3  

Unigene Cluster for GADD45G:

Growth arrest and DNA-damage-inducible, gamma
Hs.9701  [show with all ESTs]
Unigene Representative Sequence: BM903699
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000252506(uc004aqq.3) ENST00000375769 ENST00000494726
miRNA
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4 QIAGEN miScript miRNA Assays for microRNAs that regulate GADD45G:
hsa-miR-383 hsa-miR-1468 hsa-miR-4297 hsa-miR-330-3p
SwitchGear 3'UTR luciferase reporter plasmidGADD45G 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for GADD45G
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GADD45G
Clone
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OriGene ORF clones in mouse, rat for GADD45G
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: GADD45G (NM_006705)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for GADD45G
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GADD45G
Sirion Biotech Customized lentivirus for stable overexpression of GADD45G 
                     Customized lentivirus expression plasmids for stable overexpression of GADD45G 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for GADD45G
OriGene qSTAR qPCR primer pairs in human, mouse for GADD45G
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GADD45G
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GADD45G
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GADD45G

Additional mRNA sequence: 

AF078078.1 AF079806.1 AF087883.1 AK313689.1 AY845250.1 BC000465.2 BC019325.1 BT007234.1 
CR457038.1 D83023.1 

6 DOTS entries:

DT.213272  DT.100008291  DT.100794606  DT.100754232  DT.97774975  DT.100708278 

24/216 AceView cDNA sequences (see all 216):

H18438 BE045174 AI934809 CB242624 BI962804 CD370015 CR591382 BM706133 
AI801925 AI200552 AI399731 BU165285 BM709163 AI570609 CA310319 CB306320 
AI828622 BQ771836 AW299857 BQ772302 BF431748 CR617419 CD366714 AI364092 

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for GADD45G (see all 6)    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d
SP1:                                                                  
SP2:                                -                                 
SP3:                          -                                       
SP4:                                                                  
SP5:                                                                  


ECgene alternative splicing isoforms for GADD45G

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GADD45G expression in normal human tissues (normalized intensities)      GADD45G embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGTTGCTGCT
GADD45G Expression
About this image


GADD45G expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/25 selected tissues (see all 25) fully expand
 
 Brain (Nervous System)    fully expand to see all 9 entries
         Thalamus
         brain/midbrain   
 
 Blood (Muscoskeletal System)    fully expand to see all 4 entries
         Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   
         cd31+ cells   
 
 Bone (Muscoskeletal System)    fully expand to see all 3 entries
         Chondrocytes Zeugopod Epiphyseal End
         Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   
         sensory organ/ear/inner ear   
 
 Neural Tube (Nervous System)    fully expand to see all 3 entries
         Metencephalon
 
 Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
         Chondrocytes Zeugopod Epiphyseal End
         sensory organ/ear/inner ear   

See GADD45G Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GADD45G

SOURCE GeneReport for Unigene cluster: Hs.9701
    SABiosciences Expression via Pathway-Focused PCR Arrays including GADD45G: 
          DNA Damage Signaling Pathway in human mouse rat
          Cancer PathwayFinder in human mouse rat
          Stress & Toxicity PathwayFinder in human mouse rat
          Osmotic Stress in human mouse rat

Primer
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GADD45G
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GADD45G
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GADD45G

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for GADD45G gene from 6/12 species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Gadd45g1 , 5 growth arrest and DNA-damage-inducible 45 gamma1, 5 88.26(n)1
96.86(a)1
  13 (26.36 cM)5
238821  NM_011817.21  NP_035947.21 
 518466785 
chicken
(Gallus gallus)
Aves GADD45B1 growth arrest and DNA-damage-inducible, beta 76.1(n)
77.99(a)
  429929  NM_001044666.1  NP_001038131.1 
lizard
(Anolis carolinensis)
Reptilia GADD45G6
Uncharacterized protein
73(a)
1 ↔ 1
GL343512.1(189584-192653)
African clawed frog
(Xenopus laevis)
Amphibia AJ414384.12   -- 77.5(n)    AJ414384.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.118282 Transcribed sequence with weak similarity to protein more 73.1(n)    BM070829.1 
fruit fly
(Drosophila melanogaster)
Insecta Gadd456
Gadd45
25(a)
1 → many
2R(3136668-3138160)


ENSEMBL Gene Tree for GADD45G (if available)
TreeFam Gene Tree for GADD45G (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for GADD45G gene
GADD45B2  GADD45A2  
3 SIMAP similar genes for GADD45G using alignment to 5 protein entries:     GA45G_HUMAN (see all proteins):
GRP17    GADD45B    GADD45A

GADD45G for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/128 SNPs in GADD45G are shown (see all 128)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1383409721,2
--92217939(+) ATGCCA/GCCTGG 1 -- us2k10--------
rs1165071701,2
F--92217968(+) TCTCCC/ACCCGT 1 -- us2k11Minor allele frequency- A:0.06WA 118
rs1496291051,2
--92217986(+) AGACAA/CCTCTG 1 -- us2k10--------
rs1433473501,2
--92218006(+) AATGCC/TAGGAG 1 -- us2k10--------
rs20319691,2
C,F,H--92218027(-) TCTAAG/CAATGA 1 -- us2k110Minor allele frequency- C:0.09NA EA NS 536
rs1160455681,2
F--92218046(+) AGGGCC/TGGGCT 1 -- us2k11Minor allele frequency- T:0.01WA 118
rs31384821,2
C,F--92218060(+) GCAGCT/GCTCCT 1 -- us2k11Minor allele frequency- G:0.01NS 178
rs21832971,2
C,F--92218108(-) CCAAGG/TTGAGA 1 -- us2k18Minor allele frequency- T:0.19NS NA 438
rs1127572851,2
C--92218127(+) CTGCCT/-TGCAA 1 -- us2k11Minor allele frequency- -:0.50CSA 2
rs1483488131,2
--92218150(+) AACTTA/CCCCAT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for GADD45G (92219927 - 92221470 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for GADD45G:    About this table     
Variant IDTypeSubtypePubMed ID
nsv509309CNV Insertion20534489
nsv893558CNV Gain21882294
esv29434CNV Gain+Loss19812545
nsv471662CNV Gain+Loss15918152
nsv469563CNV Complex16826518

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 604949    OMIM disorders: --

14 diseases for GADD45G:    About MalaCards
thyroid cancer    pituitary adenoma    retinoblastoma    ovarian cancer
cervical cancer    adenoma    pancreatic cancer    cervicitis
thyroiditis    hepatocellular carcinoma    pancreatitis    prostate cancer
melanoma    prostatitis


GADD45G for disorders           About GeneDecksing

4 Novoseek inferred disease relationships for GADD45G gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
lung carcinoma 43.2 2 10490824 (1), 11251170 (1)
retinoblastoma 38.1 1 10597261 (1)
tumors 13.2 3 12915687 (1), 18299662 (1), 14672412 (1)
cancer 0 3 17178890 (2), 12915687 (1)

Genetic Association Database (GAD): GADD45G
Human Genome Epidemiology (HuGE) Navigator: GADD45G (3 documents)

Export disorders for GADD45G gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for GADD45G gene, integrated from 9 sources (see all 52):
(articles sorted by number of sources associating them with GADD45G)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. (PubMed id 9827804)1, 2, 3, 9 Takekawa M. and Saito H. (1998)
  2. Cytokine response gene 6 induces p21 and regulates both cell growth and arrest. (PubMed id 10597261)1, 2, 9 Fan W.... Smith K.A. (1999)
  3. Molecular cloning, expression, and mapping of a novel human cDNA, GRP17, highly homologous to human gadd45 and murine MyD118. (PubMed id 10496071)1, 3, 9 Suzuki M....Tanigami A. (1999)
  4. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (2008)
  5. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PubMed id 18464913)1, 4 Melzer D....Ferrucci L. (2008)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  7. CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle. (PubMed id 12716909)1, 2 Chung H.K.... Shong M. (2003)
  8. Assignment of human GADD45G to chromosome 9q22.1-->q22.3 by radiation hybrid mapping. (PubMed id 10773677)1, 2 Gong R.... Zhao S. (2000)
  9. Interaction of CR6 (GADD45gamma ) with proliferating cell nuclear antigen impedes negative growth control. (PubMed id 11022036)1, 9 Azam N....Liebermann D.A. (2001)
  10. CR6: A third member in the MyD118 and Gadd45 gene family which functions in negative growth control. (PubMed id 10490824)1, 9 Zhang W....Liebermann D.A. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 10912 HGNC: 4097 AceView: GADD45G Ensembl:ENSG00000130222 euGenes: HUgn10912
ECgene: GADD45G Kegg: 10912 H-InvDB: GADD45G

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for GADD45G Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for GADD45G Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPshttp://egp.gs.washington.edu/data/gadd45g/
Wikipedia http://en.wikipedia.org/wiki/GADD45G

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for GADD45G gene:
Search GeneIP for patents involving GADD45G

GeneCards and IP:
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