Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GADD45G Gene

protein-coding   GIFtS: 63
GCID: GC09P092219

Growth Arrest And DNA-Damage-Inducible, Gamma

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Growth Arrest And DNA-Damage-Inducible, Gamma1 2     17 KD1
Cytokine-Responsive Protein CR62 3     Gadd-Related Protein1
CR62 3     Growth Arrest And DNA-Damage-Inducible Gamma1
DDIT-22 3     GADD45-gamma2
DDIT22 3     GADD45gamma2
DNA Damage-Inducible Transcript 2 Protein2 3     Gadd-Related Protein, 17 KD2
GRP172 5     Growth Arrest And DNA Damage-Inducible Protein GADD45 Gamma2

External Ids:    HGNC: 40971   Entrez Gene: 109122   Ensembl: ENSG000001302227   OMIM: 6049495   UniProtKB: O952573   

Export aliases for GADD45G gene to outside databases

Previous GC identifers: GC09P083195 GC09P084099 GC09P085804 GC09P087711 GC09P089449 GC09P091409 GC09P062051


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GADD45G Gene:
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest
conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental
stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in
placenta. (provided by RefSeq, Jul 2008)

GeneCards Summary for GADD45G Gene:
GADD45G (growth arrest and DNA-damage-inducible, gamma) is a protein-coding gene. Diseases associated with GADD45G include retinoblastoma, and thyroid cancer. An important paralog of this gene is GADD45B.

UniProtKB/Swiss-Prot: GA45G_HUMAN, O95257
Function: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4
MAPKKK

Gene Wiki entry for GADD45G Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the GADD45G gene promoter:
         GR   Pax-5   HOXA3   p53   CUTL1   NF-AT   C/EBPalpha   GR-alpha   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GADD45G promoter sequence
   Search Chromatin IP Primers for GADD45G

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GADD45G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.1-q22.2   Ensembl cytogenetic band:  9q22.2   HGNC cytogenetic band: 9q22.1-q22.2

GADD45G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GADD45G gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P092219:  view genomic region     (about GC identifiers)

Start:
92,219,927 bp from pter      End:
92,221,470 bp from pter
Size:
1,544 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GA45G_HUMAN, O95257 (See protein sequence)
Recommended Name: Growth arrest and DNA damage-inducible protein GADD45 gamma  
Size: 159 amino acids; 17121 Da
Subunit: Interacts with GADD45GIP1
2 PDB 3D structures from and Proteopedia for GADD45G:
2WAL (3D)        3FFM (3D)    
Secondary accessions: Q9C076

Explore the universe of human proteins at neXtProt for GADD45G: NX_O95257

Explore proteomics data for GADD45G at MOPED


See GADD45G Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_006696.1  
ENSEMBL proteins: 
 ENSP00000252506   ENSP00000364924  

GADD45G Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Proteins for GADD45G
OriGene Protein Over-expression Lysate for GADD45G
OriGene MassSpec for GADD45G
OriGene Custom Protein Services for GADD45G
GenScript Custom Purified and Recombinant Proteins Services for GADD45G
Novus Biologicals GADD45G Proteins
Novus Biologicals GADD45G Lysates
Sino Biological Recombinant Protein for GADD45G
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for GADD45G
Browse Proteins at Cloud-Clone Corp.

GADD45G Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
OriGene Antibodies for GADD45G
OriGene Custom Antibody Services for GADD45G
Novus Biologicals GADD45G Antibodies
Abcam antibodies for GADD45G
Browse Antibodies at Cloud-Clone Corp.
ThermoFisher Antibodies for GADD45G
LSBio Antibodies in human, mouse, rat for GADD45G

GADD45G Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for GADD45G
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for GADD45G
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
2 InterPro protein domains:
 IPR024824 GADD45
 IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45

Graphical View of Domain Structure for InterPro Entry O95257

ProtoNet protein and cluster: O95257

1 Blocks protein domain: IPB004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45

UniProtKB/Swiss-Prot: GA45G_HUMAN, O95257
Similarity: Belongs to the GADD45 family


GADD45G for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: GA45G_HUMAN, O95257
Function: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4
MAPKKK

     Genatlas biochemistry entry for GADD45G:
growth arrest and DNA-damage inducible,gamma,involved in negative control of cell growth

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI12716909
     
GADD45G for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for GADD45G:
 Increased HPV18 LCR reporter a 

     6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Gadd45g):
 cellular  endocrine/exocrine gland  hematopoietic system  immune system  renal/urinary system 
 reproductive system 

GADD45G for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for GADD45G: Gadd45gtm1Flv Gadd45gtm1Mhol Gadd45gtm1Jni

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GADD45G
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GADD45G

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GADD45G
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GADD45G

miRNA
Products:
    
miRTarBase miRNAs that target GADD45G:
hsa-mir-181a-5p (MIRT025170)

Block miRNA regulation of human, mouse, rat GADD45G using miScript Target Protectors
4 qRT-PCR Assays for microRNAs that regulate GADD45G:
hsa-miR-383 hsa-miR-1468 hsa-miR-4297 hsa-miR-330-3p
SwitchGear 3'UTR luciferase reporter plasmidGADD45G 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for GADD45G
Predesigned siRNA for gene silencing in human, mouse, rat GADD45G

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for GADD45G

Clone
Products:
     
OriGene clones in human, mouse for GADD45G (see all 6)
OriGene ORF clones in mouse, rat for GADD45G
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: GADD45G (NM_006705)
Sino Biological Human cDNA Clone for GADD45G
DNA2.0 Custom Codon Optimized Gene Synthesis Service for GADD45G
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GADD45G

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for GADD45G
Browse ESI BIO Cell Lines and PureStem Progenitors for GADD45G 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GADD45G


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular2
nucleus2
cytosol1
mitochondrion1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA9827804
GO:0005737cytoplasm IDA9827804

GADD45G for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for GADD45G About   (see all 12)  
See pathways by source

SuperPathContained pathways About
1p53 signaling pathway
DNA damage response0.41
p53 signaling pathway0.41
2IL12-mediated signaling events
Immune response IL 12 induced IFN gamma production0.33
IL12-mediated signaling events0.33
3Cell cycle
Cell cycle0.59
4MAPK signaling pathway
MAPK signaling pathway0.50
5p53 Signaling
p53 Signaling0.38

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GADD45G
    ATM Pathway
BRCA1 Pathway
DNA Repair Mechanisms
p53 Signaling
GADD45 Pathway

1 GeneGo (Thomson Reuters) Pathway for GADD45G
    Immune response IL-12-induced IFN-gamma production

3 BioSystems Pathways for GADD45G
    DNA damage response
p38 MAPK signaling pathway
IL12-mediated signaling events



4 Kegg Pathways  (Kegg details for GADD45G):
    MAPK signaling pathway
FoxO signaling pathway
Cell cycle
p53 signaling pathway


GADD45G for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Arrays including GADD45G: 
          DNA Damage Signaling Pathway in human mouse rat
          Cancer PathwayFinder in human mouse rat
          Stress & Toxicity PathwayFinder in human mouse rat
          Osmotic Stress in human mouse rat

Interactions:

    GeneGlobe Interaction Network for GADD45G

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for GADD45G (O952571, 2, 3 ENSP000002525064) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
InteractantInteraction Details
GeneCardExternal ID(s)
GADD45GIP1Q8TAE81, 2, 3, ENSP000003230654EBI-448202,EBI-372506 MINT-17694 MINT-17693 I2D: score=5 STRING: ENSP00000323065
KIAA1377Q9P2H01, 2, 3, ENSP000002634684EBI-448202,EBI-473176 MINT-3981610 MINT-3979313 I2D: score=2 STRING: ENSP00000263468
DDAH2O958652, 3MINT-8256162 I2D: score=2 
ENSG00000206395O958652, 3MINT-8256162 I2D: score=2 
ENSG00000225635O958652, 3MINT-8256162 I2D: score=2 
About this table

Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000185activation of MAPKKK activity IDA9827804
GO:0000186activation of MAPKK activity IEA--
GO:0006469negative regulation of protein kinase activity IEA--
GO:0006915apoptotic process IEA--
GO:0006950response to stress IEA--

GADD45G for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for GADD45G (GA45G)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for GADD45G gene: 
NM_006705.3  

Unigene Cluster for GADD45G:

Growth arrest and DNA-damage-inducible, gamma
Hs.9701  [show with all ESTs]
Unigene Representative Sequence: BM903699
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000252506(uc004aqq.3) ENST00000375769 ENST00000494726
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat GADD45G using miScript Target Protectors
4 qRT-PCR Assays for microRNAs that regulate GADD45G:
hsa-miR-383 hsa-miR-1468 hsa-miR-4297 hsa-miR-330-3p
SwitchGear 3'UTR luciferase reporter plasmidGADD45G 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for GADD45G
Predesigned siRNA for gene silencing in human, mouse, rat GADD45G
Clone
Products:
     
OriGene clones in human, mouse for GADD45G (see all 6)
OriGene ORF clones in mouse, rat for GADD45G
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: GADD45G (NM_006705)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for GADD45G
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GADD45G
Primer
Products:
    
OriGene qPCR primer pairs and template standards for GADD45G
OriGene qSTAR qPCR primer pairs in human, mouse for GADD45G
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GADD45G
  QuantiTect SYBR Green Assays in human, mouse, rat GADD45G
  QuantiFast Probe-based Assays in human, mouse, rat GADD45G

Additional mRNA sequence: 

AF078078.1 AF079806.1 AF087883.1 AK313689.1 AY845250.1 BC000465.2 BC019325.1 BT007234.1 
CR457038.1 D83023.1 

6 DOTS entries:

DT.213272  DT.100008291  DT.100794606  DT.100754232  DT.97774975  DT.100708278 

Selected AceView cDNA sequences (see all 216):

BF219948 CD366714 BQ026535 BF478067 AI707756 AI934809 CR619521 BM975764 
BE045174 AI801925 CA947139 CA946861 AI933218 BF434312 BQ771836 BU165285 
AI130953 BQ772302 CR605667 H18438 AI399731 AW119208 AI828622 AW299857 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for GADD45G (see all 6)    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d
SP1:                                                                  
SP2:                                -                                 
SP3:                          -                                       
SP4:                                                                  
SP5:                                                                  


ECgene alternative splicing isoforms for GADD45G

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

GADD45G expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGTTGCTGCT
GADD45G Expression
About this image


GADD45G expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 8) fully expand
 
 Brain (Nervous System)    fully expand to see all 6 entries
         Cerebral Cortex
 
 Neural Tube (Nervous System)    fully expand to see all 3 entries
         Metencephalon
 
 Kidney (Urinary System)
         Metanephros
 
 Bone (Muscoskeletal System)
         Chondrocytes Zeugopod Epiphyseal End
 
 Eye (Sensory Organs)
         Lens
GADD45G Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

GADD45G Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.9701
    Pathway & Disease-focused RT2 Profiler PCR Arrays including GADD45G: 
          DNA Damage Signaling Pathway in human mouse rat
          Cancer PathwayFinder in human mouse rat
          Stress & Toxicity PathwayFinder in human mouse rat
          Osmotic Stress in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for GADD45G
OriGene qSTAR qPCR primer pairs in human, mouse for GADD45G
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GADD45G
QuantiTect SYBR Green Assays in human, mouse, rat GADD45G
QuantiFast Probe-based Assays in human, mouse, rat GADD45G
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GADD45G

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of chordates.

Orthologs for GADD45G gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Gadd45g1 , 5 growth arrest and DNA-damage-inducible 45 gamma1, 5 88.26(n)1
96.86(a)1
  13 (26.36 cM)5
238821  NM_011817.21  NP_035947.21 
 518466785 
chicken
(Gallus gallus)
Aves GADD45B1 growth arrest and DNA-damage-inducible, beta 76.1(n)
77.99(a)
  429929  NM_001044666.1  NP_001038131.1 
lizard
(Anolis carolinensis)
Reptilia GADD45G6
growth arrest and DNA-damage-inducible, gamma
49(a)
1 ↔ 1
GL343512.1(189584-192653)
African clawed frog
(Xenopus laevis)
Amphibia AJ414384.12   -- 77.5(n)    AJ414384.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.118282 Transcribed sequence with weak similarity to protein more 73.1(n)    BM070829.1 


ENSEMBL Gene Tree for GADD45G (if available)
TreeFam Gene Tree for GADD45G (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for GADD45G gene
GADD45B2  GADD45A2  
3 SIMAP similar genes for GADD45G using alignment to 5 protein entries:     GA45G_HUMAN (see all proteins):
GRP17    GADD45B    GADD45A

GADD45G for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for GADD45G (see all 128)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1383409721,2
--92217939(+) ATGCCA/GCCTGG 1 -- us2k10--------
rs1165071701,2
F--92217968(+) TCTCCC/ACCCGT 1 -- us2k11Minor allele frequency- A:0.06WA 118
rs1496291051,2
--92217986(+) AGACAA/CCTCTG 1 -- us2k10--------
rs1433473501,2
--92218006(+) AATGCC/TAGGAG 1 -- us2k10--------
rs20319691,2
C,F,H--92218027(-) TCTAAG/CAATGA 1 -- us2k110Minor allele frequency- C:0.09NA EA NS 536
rs1160455681,2
F--92218046(+) AGGGCC/TGGGCT 1 -- us2k11Minor allele frequency- T:0.01WA 118
rs31384821,2
C,F--92218060(+) GCAGCT/GCTCCT 1 -- us2k11Minor allele frequency- G:0.01NS 178
rs21832971,2
C,F--92218108(-) CCAAGG/TTGAGA 1 -- us2k18Minor allele frequency- T:0.19NS NA 438
rs1127572851,2
C--92218127(+) CTGCCT/-TGCAA 1 -- us2k11Minor allele frequency- -:0.50CSA 2
rs1483488131,2
--92218150(+) AACTTA/CCCCAT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for GADD45G (92219927 - 92221470 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for GADD45G:    About this table    
Variant IDTypeSubtypePubMed ID
nsv509309CNV Insertion20534489
nsv893558CNV Gain21882294
esv29434CNV Gain+Loss19812545
nsv471662CNV Gain+Loss15918152
nsv469563CNV Complex16826518

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing GADD45G
DNA2.0 Custom Variant and Variant Library Synthesis for GADD45G

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 604949    OMIM disorders: --

18 diseases for GADD45G:    
About MalaCards
retinoblastoma    thyroid cancer    pituitary adenoma    cleft palate
cleft lip    cervical cancer    adenoma    cervicitis
huntington's disease    thyroiditis    pancreatic cancer    ovarian cancer
hepatocellular carcinoma    pancreatitis    prostate cancer    melanoma
prostatitis    cerebritis


GADD45G for disorders           About GeneDecksing

4 Novoseek inferred disease relationships for GADD45G gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
lung carcinoma 43.2 2 10490824 (1), 11251170 (1)
retinoblastoma 38.1 1 10597261 (1)
tumors 13.2 3 12915687 (1), 18299662 (1), 14672412 (1)
cancer 0 3 17178890 (2), 12915687 (1)

Genetic Association Database (GAD): GADD45G
Human Genome Epidemiology (HuGE) Navigator: GADD45G (3 documents)

Export disorders for GADD45G gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for GADD45G gene, integrated from 10 sources (see all 55):
(articles sorted by number of sources associating them with GADD45G)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. (PubMed id 9827804)1, 2, 3, 9 Takekawa M. and Saito H. (Cell 1998)
  2. Cytokine response gene 6 induces p21 and regulates both cell growth and arrest. (PubMed id 10597261)1, 2, 9 Fan W.... Smith K.A. (Oncogene 1999)
  3. Molecular cloning, expression, and mapping of a novel human cDNA, GRP17, highly homologous to human gadd45 and murine MyD118. (PubMed id 10496071)1, 3, 9 Suzuki M....Tanigami A. (J. Hum. Genet. 1999)
  4. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (amp 2008)
  5. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PubMed id 18464913)1, 4 Melzer D....Ferrucci L. (PLoS Genet. 2008)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle. (PubMed id 12716909)1, 2 Chung H.K.... Shong M. (J. Biol. Chem. 2003)
  8. Assignment of human GADD45G to chromosome 9q22.1-->q22.3 by radiation hybrid mapping. (PubMed id 10773677)1, 2 Gong R.... Zhao S. (Cytogenet. Cell Genet. 2000)
  9. Interaction of CR6 (GADD45gamma ) with proliferating cell nuclear antigen impedes negative growth control. (PubMed id 11022036)1, 9 Azam N....Liebermann D.A. (J. Biol. Chem. 2001)
  10. CR6: A third member in the MyD118 and Gadd45 gene family which functions in negative growth control. (PubMed id 10490824)1, 9 Zhang W....Liebermann D.A. (Oncogene 1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 10912 HGNC: 4097 AceView: GADD45G Ensembl:ENSG00000130222 euGenes: HUgn10912
ECgene: GADD45G Kegg: 10912 H-InvDB: GADD45G

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for GADD45G Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for GADD45G Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPshttp://egp.gs.washington.edu/data/gadd45g/
Wikipedia http://en.wikipedia.org/wiki/GADD45G

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for GADD45G gene:
Search GeneIP for patents involving GADD45G

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for GADD45G   OriGene RNAi products in human, mouse, rat for GADD45G  
 OriGene qPCR primer pairs and template standards for GADD45G   OriGene Protein Over-expression Lysate for GADD45G  
 OriGene MassSpec something-or-other for GADD45G   OriGene clones in human, mouse for GADD45G  
 OriGene qSTAR qPCR primer pairs in human, mouse for GADD45G   OriGene Purified Protein for GADD45G  
 OriGene ORF clones in mouse, rat for GADD45G   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for GADD45G   OriGene Custom Protein Services for GADD45G  

 
 
 Block miRNA regulation of human, mouse, rat GADD45G using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GADD45G
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GADD45G Predesigned siRNA for gene silencing in human, mouse, rat GADD45G
 QuantiFast Probe-based Assays in human, mouse, rat GADD45G QuantiTect SYBR Green Assays in human, mouse, rat GADD45G
 PCR Arrays including human, mouse, rat GADD45G Search Chromatin IP Primers for GADD45G
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GADD45G  GeneGlobe Interaction Network for GADD45G
 Regulatory tfbs in GADD45G promoter
 GenScript Custom Purified and Recombinant Proteins Services for GADD45G GenScript cDNA clones with any tag delivered in your preferred vector for GADD45G
 GenScript Custom Assay Services for GADD45G GenScript Custom overexpressing Cell Line Services for GADD45G
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for GADD45G (GA45G)
 Proteins for GADD45G
 Browse Sino Biological Cell Lysates
 cDNA Clones for GADD45G
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 GADD45G antibodies
 GADD45G proteins
 GADD45G lysates
 Antibodies for GADD45G
 See all of Abcam's Antibodies, Kits and Proteins for GADD45G
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Recombinant Protein for GADD45G
 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.



 Browse ESI BIO Cell Lines and PureStem Progenitors for GADD45G
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GADD45G
 SwitchGear 3'UTR luciferase reporter plasmids for GADD45G
 SwitchGear Promoter luciferase reporter plasmids for GADD45G
 ThermoFisher Antibodies for GADD45G
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GADD45G
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GADD45G
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GADD45G
 LSBio Antibodies in human, mouse, rat for GADD45G
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      GADD45G gene at Home site.
Version: 3.12.142 28 July 2014
hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4