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Aliases & Descriptions for GADD45G
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CR6 1, 2, 3 | | DDIT-2 3 | | DDIT2 1, 2, 3 | | GADD45-gamma 2 | | GADD45gamma 1, 2 | | GRP17 1, 2, 5 | | OTTHUMP00000021623 2 |
| | | Descriptions |
|---|
| Cytokine-responsive protein CR6 3 | | DNA-damage-inducible transcript 2 3 | | gadd-related protein, 17 kD 2 | | growth arrest and DNA-damage-inducible, gamma 2 |
|
| | Search outside databases for aliases for GADD45G genePrevious GC identifers: GC09P083195 GC09P084099 GC09P085804 GC09P087711 GC09P089449 |
Summaries for GADD45G(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for GADD45G: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq] UniProtKB/Swiss-Prot: GA45G_HUMAN, O95257Function: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKKGene Wiki entry for GADD45G |
Genomic Location for GADD45G
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the GADD45G gene 
Entrez Gene cytogenetic band: 9q22.1-q22.2 Ensembl cytogenetic band: 9q22.2 HGNC cytogenetic band: 9q22.1-q22.2GADD45G Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P091409:
(about GC identifiers)
Start:
|
91,409,748 bp from pter |
End:
|
91,411,290 bp from pter |
Size:
|
1,543 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000009.10 NT_023935.17
| Proteins for GADD45G
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: GA45G_HUMAN, O95257 (See
protein sequence)Recommended Name: Growth arrest and DNA-damage-inducible protein GADD45 gamma Size: 159 amino acids; 17121 Da
Subunit: Interacts with GADD45GIP1
PDB structures from and Proteopedia :2WAL (3D)
 
Secondary accessions: Q9C076REFSEQ proteins: NP_006696.1
ENSEMBL proteins: ENSP00000252506 ENSP00000364924
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: GADD45G 
Antibodies for GADD45G: Assays for GADD45G: | Protein
Domains/ Families for GADD45G(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O95257
ProtoNet protein and cluster: O95257 1 Blocks protein family: IPB004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45
UniProtKB/Swiss-Prot: GA45G_HUMAN, O95257Similarity: Belongs to the GADD45 family | Gene Function for GADD45G
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006705
Applied Biosystems Silencer® siRNAs for GADD45G
Sigma-Aldrich siRNA and siRNA Panels for GADD45G  Sigma-Aldrich shRNA Panels and shRNA for GADD45G  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006705                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006705                                  untagged cDNA clone in CMV expression vector: NM_006705 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006705
UniProtKB/Swiss-Prot: GA45G_HUMAN, O95257Function: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKKGenatlas biochemistry entry for GADD45G:growth arrest and DNA-damage inducible,gamma,involved in negative control of cell growth5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Gadd45g):
1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for GADD45G
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Sigma-Aldrich "Your Favorite Gene" Pathways for GADD45G (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for GADD45G 
5/52 Interacting proteins for GADD45G (ENSP000002525063 O952571, 2) via UniProtKB, MINT, and/or STRING (see all 52
)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| HTATIP | Q929931, 2 | EBI-448202, EBI-399080 MINT-3979086 MINT-3981674 | | KAT5 | Q929931, 2 | EBI-448202, EBI-399080 MINT-3979086 MINT-3981674 | | GADD45GIP1 | Q8TAE81, 2 | STRING (score=.941) EBI-448202, EBI-372506 MINT-17694 MINT-17693 EBI-448202, EBI-372506 MINT-17694 MINT-17693 | | MED31 | Q9Y3C71, 2 | EBI-448202, EBI-394707 MINT-3979222 MINT-3981770 EBI-448202, EBI-394707 MINT-3979222 MINT-3981770 | | UTP14A | Q9BVJ61, 2 | EBI-448202, EBI-473284 MINT-3981722 MINT-3979330 EBI-448202, EBI-473284 MINT-3981722 MINT-3979330 | About this table
5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6
): About this table
|
Drugs & Compounds for GADD45G(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for GADD45G
|
Transcripts for GADD45G(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006705
Sigma-Aldrich siRNA and siRNA Panels for GADD45G  Sigma-Aldrich shRNA Panels and shRNA for GADD45G  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006705 REFSEQ mRNAs for GADD45G gene: NM_006705.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006705               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006705                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006705                                  untagged cDNA clone in CMV expression vector: NM_006705  Additional cDNA sequence: AF078078.1 AF079806.1 AF087883.1 AK313689.1 AY845250.1 BC000465.2 BC019325.1 BT007234.1 CR457038.1 CR591382.1 CR595761.1 CR601992.1 CR605667.1 CR613579.1 CR617419.1 CR619521.1 D83023.1 6 DOTS entries: DT.213272 DT.100008291 DT.100794606 DT.100754232 DT.97774975 DT.100708278 24/216 AceView cDNA sequences (see all 216
):H18438 CB306320 BE294373 AI130953 AI570609 CR601992 BQ026535 AI219115 BM706133 AI828622 BI789283 BE045174 AI399731 CD370015 AI934809 CR595761 BF219948 R59884 AI934818 BC000465 AI497791 CR613579 BM709163 BQ772302
highest scoring ESTs for GADD45G:AI952982 AA205163 AA292919 AA308947 AA402224 AA424495 AA628027 AA679099 AA719323 AA745886 Unigene Cluster for GADD45G: Growth arrest and DNA-damage-inducible, gamma Hs.9701 [show with all ESTs]Unigene Representative Sequence: CR613579
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for GADD45G (see all 6
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for GADD45G
2 Ensembl transcripts including schematic representations: ENST00000252506
ENST00000375769
|
Expression for GADD45G
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| GADD45G expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for GADD45G
1 / 2 / 3 3 probe-sets matching GADD45G gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AGTTGCTGCT
SOURCE GeneReport for Unigene cluster: Hs.9701
Expression variation in blood from EXPOLDB for GADD45G |
Orthologs for GADD45G
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GADD45G gene from 5/9 species (see all 9
)
About this table Species with no ortholog for GADD45G
ENSEMBL Gene Tree for GADD45G | Paralogs for GADD45G(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for GADD45G gene
- GADD45B2 GADD45A2
|
SNPs/Variants for GADD45G(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for GADD45G (up to first 250kb)
|
Disorders & Mutations for GADD45G
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604949
4 Novoseek disease relationships for GADD45G gene
About this table
Human Genome Epidemiology Navigator: GADD45G (1 document)
|
Medical News for GADD45G(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for GADD45G (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/36 PubMed articles for GADD45G gene (see all 36
):- A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. (PubMed id 9827804)1, 2, 3, 4 Takekawa M. and Saito H. (1998)
- Cytokine response gene 6 induces p21 and regulates both cell growth and arrest. (PubMed id 10597261)1, 3, 4 Fan W.... Smith K.A. (1999)
- Molecular cloning, expression, and mapping of a novel human cDNA, GRP17, highly homologous to human gadd45 and murine MyD118. (PubMed id 10496071)1, 2, 3 Suzuki M....Tanigami A. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle. (PubMed id 12716909)3, 4 Chung H.K.... Shong M. (2003)
- Assignment of human GADD45G to chromosome 9q22.1-->q22.3 by radiation hybrid mapping. (PubMed id 10773677)3, 4 Gong R.... Zhao S. (2000)
- Interaction of CR6 (GADD45gamma ) with proliferating cell nuclear antigen impedes negative growth control. (PubMed id 11022036)1, 3 Azam N....Liebermann D.A. (2001)
- CR6: A third member in the MyD118 and Gadd45 gene family which functions in negative growth control. (PubMed id 10490824)1, 3 Zhang W....Liebermann D.A. (1999)
- A novel pathway involving melanoma differentiation associated gene-7/interleukin-24 mediates nonsteroidal anti-inflammatory drug-induced apoptosis and growth arrest of cancer cells. (PubMed id 17178890)1, 3 Zerbini L.F....Libermann T.A. (2006)
- GADD45gamma, down-regulated in 65% hepatocellular carcinoma (HCC) from 23 chinese patients, inhibits cell growth and induces cell cycle G2/M arrest for hepatoma Hep-G2 cell lines. (PubMed id 14672412)1, 3 Sun L....Yu L. (2003)
|
Search for GADD45G
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing GADD45G
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing GADD45G
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GADD45G(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for GADD45G(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for GADD45G:

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Incremental update: 13 Oct 2009
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