GADD45G Gene

Aliases
for GADD45G gene

Previous GC identifers: GC09P083195 GC09P084099 GC09P085804 GC09P087711 GC09P089449 GC09P091409 GC09P062051

Summaries
for GADD45G gene

Genomic Views
for GADD45G gene

RefSeq DNA sequence:

NC_000009.11  NC_018920.1  NT_008470.19  

SwitchGear Promoter luciferase reporter plasmids (see all 2): GADD45G promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GADD45G

GADD45G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P092219:  view genomic region     (about GC identifiers)

Proteins
for GADD45G gene

2 PDB 3D structures from and Proteopedia for GADD45G:

2WAL (3D)        3FFM (3D)    

Explore the universe of human proteins at neXtProt for GADD45G: NX_O95257

GADD45G Protein expression data from MOPED and PaxDb:    About this image 

	Browse Purified and Recombinant Proteins at EMD Millipore
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	OriGene Purified Protein: GADD45G OriGene Protein Over-expression Lysate: GADD45G OriGene Custom Protein Services for GADD45G
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	Novus Biologicals GADD45G Proteins Novus Biologicals GADD45G Lysates
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	ProSpec Recombinant Protein for GADD45G
	Browse Proteins at Uscn

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

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	OriGene Antibodies (see all 27): GADD45G OriGene Custom Antibody Services for GADD45G
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	ThermoFisher Antibodies for GADD45G

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	Browse ELISAs and CLIAs at Uscn

Protein Domains /
Families
for GADD45G gene

ProtoNet protein and cluster: O95257

Function
for GADD45G gene

miRNA Products:		OriGene 3'-UTR Clone: GADD45G Browse MicroRNA Expression Plasmids
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		4 QIAGEN miScript miRNA Assays for microRNAs that regulate GADD45G:
		hsa-miR-383 hsa-miR-1468 hsa-miR-4297 hsa-miR-330-3p
		SwitchGear 3'UTR luciferase reporter plasmid: GADD45G 3' UTR sequence

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GADD45G (see all 7) OriGene shRNA RFP: GADD45G OriGene siRNA: GADD45G
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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for GADD45G

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GADD45G

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

(inferred from 3 alleles) (MGI details for Gadd45g)

Pathways & Interactions
for GADD45G gene

	Super-pathway	contained gene-specific pathways
1	Immune response IL-12-induced IFN-gamma production	Immune response IL-12-induced IFN-gamma production 1.00 IL12-mediated signaling events 0.33 Immune response_IL-12-induced IFN-gamma production 0.88
2	p53 signaling pathway	p53 signaling pathway 1.00 DNA damage response 0.40
3	Chks in Checkpoint Regulation	p53 Signaling 0.32 DNA Repair Mechanisms 0.32
4	Selected targets of Oct-3/4	Selected targets of Oct-3/4 1.00
5	BRCA1 Pathway	BRCA1 Pathway 1.00

2 EMD Millipore Pathways for GADD45G

	Selected targets of Oct-3/4
	Immune response IL-12-induced IFN-gamma production

5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GADD45G

	ATM Pathway
	BRCA1 Pathway
	DNA Repair Mechanisms
	p53 Signaling
	GADD45 Pathway

1 GeneGo (Thomson Reuters) Pathway for GADD45G

Immune response IL-12-induced IFN-gamma production

3 BioSystems Pathways for GADD45G

	DNA damage response
	p38 MAPK signaling pathway
	IL12-mediated signaling events

3         Kegg Pathways  (Kegg details for GADD45G)

	MAPK signaling pathway
	Cell cycle
	p53 signaling pathway

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

Drugs & Compounds
for GADD45G gene

Transcripts
for GADD45G gene

Expression
for GADD45G gene

GADD45G expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTTGCTGCT

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	HeartCardiac CrescentCardiac Crescent Cells			Myocardium
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 2 LifeMap Cells
	Name			Category
	PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
	Epiblast-like cells (Reconstitution of mo...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GADD45G Browse OriGene validated miRNA SYBR primer pairs
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GADD45G

Orthologs
for GADD45G gene

Paralogs
for GADD45G gene

Paralogs for GADD45G gene

GADD45B²  GADD45A²  

3 SIMAP similar genes for GADD45G using alignment to 5 protein entries:     GA45G_HUMAN (see all proteins):

GRP17    GADD45B    GADD45A

GADD45G for paralogs           About GeneDecksing

Genomic Variants
for GADD45G gene

10/104 NCBI SNPs in GADD45G are shown (see all 104)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1383409721,2		--	92217939(+)	ATGCCA/GCCTGG	1	--	us2k1		0	--	--	--	--
rs1165071701,2	F,	--	92217968(+)	TCTCCC/ACCCGT	1	--	us2k1		1		WA	118
rs1496291051,2		--	92217986(+)	AGACAA/CCTCTG	1	--	us2k1		0	--	--	--	--
rs1433473501,2		--	92218006(+)	AATGCC/TAGGAG	1	--	us2k1		0	--	--	--	--
rs20319691,2	C,F,H,	--	92218027(-)	TCTAAG/CAATGA	1	--	us2k1		10		NA EA NS	536
rs1160455681,2		--	92218046(+)	AGGGCC/TGGGCT	1	--	us2k1		1		WA	118
rs31384821,2	C,	--	92218060(+)	GCAGCT/GCTCCT	1	--	us2k1		1		NS	178
rs21832971,2	C,F,	--	92218108(-)	CCAAGG/TTGAGA	1	--	us2k1		8		NS NA	438
rs1127572851,2	C,	--	92218127(+)	CTGCCT/-TGCAA	1	--	us2k1		1		CSA	2
rs1483488131,2		--	92218150(+)	AACTTA/CCCCAT	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for GADD45G (92219927 - 92221470 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for GADD45G
     2 CNVs: 65451 0760

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GADD45G

DNA2.0 Custom Variant and Variant Library Synthesis for GADD45G

Disorders / Diseases
for GADD45G gene

17 diseases for GADD45G

4 Novoseek disease relationships for GADD45G gene    About this table

Publications
for GADD45G gene

PubMed articles for GADD45G gene, integrated from 9 sources (see all 47): (articles sorted by number of sources associating them with GADD45G)

Utopia: connect your pdf to the dynamic world of online information

1. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. (PubMed id 9827804)^{1, 2, 3, 9} Takekawa M. and Saito H. (1998)
2. Cytokine response gene 6 induces p21 and regulates both cell growth and arrest. (PubMed id 10597261)^{1, 2, 9} Fan W.... Smith K.A. (1999)
3. Molecular cloning, expression, and mapping of a novel human cDNA, GRP17, highly homologous to human gadd45 and murine MyD118. (PubMed id 10496071)^{1, 3, 9} Suzuki M....Tanigami A. (1999)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
5. CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle. (PubMed id 12716909)^{1, 2} Chung H.K.... Shong M. (2003)
6. Assignment of human GADD45G to chromosome 9q22.1-->q22.3 by radiation hybrid mapping. (PubMed id 10773677)^{1, 2} Gong R.... Zhao S. (2000)
7. Interaction of CR6 (GADD45gamma ) with proliferating cell nuclear antigen impedes negative growth control. (PubMed id 11022036)^{1, 9} Azam N....Liebermann D.A. (2001)
8. CR6: A third member in the MyD118 and Gadd45 gene family which functions in negative growth control. (PubMed id 10490824)^{1, 9} Zhang W....Liebermann D.A. (1999)
9. A novel pathway involving melanoma differentiation associated gene-7/interleukin-24 mediates nonsteroidal anti-inflammatory drug-induced apoptosis and growth arrest of cancer cells. (PubMed id 17178890)^{1, 9} Zerbini L.F....Libermann T.A. (2006)
10. GADD45gamma, down-regulated in 65% hepatocellular carcinoma (HCC) from 23 chinese patients, inhibits cell growth and induces cell cycle G2/M arrest for hepatoma Hep-G2 cell lines. (PubMed id 14672412)^{1, 9} Sun L....Yu L. (2003)

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