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Aliases for GADD45B Gene

Aliases for GADD45B Gene

  • Growth Arrest And DNA-Damage-Inducible, Beta 2 3
  • Myeloid Differentiation Primary Response Protein MyD118 3 4
  • Negative Growth Regulatory Protein MyD118 3 4
  • MYD118 3 4
  • Growth Arrest And DNA-Damage-Inducible Beta 2
  • Myeloid Differentiation Primary Response 2
  • GADD45BETA 3

External Ids for GADD45B Gene

Previous HGNC Symbols for GADD45B Gene

  • MYD118

Previous GeneCards Identifiers for GADD45B Gene

  • GC19P002538
  • GC19P002416
  • GC19P002427
  • GC19P002247

Summaries for GADD45B Gene

Entrez Gene Summary for GADD45B Gene

  • This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]

GeneCards Summary for GADD45B Gene

GADD45B (Growth Arrest And DNA-Damage-Inducible, Beta) is a Protein Coding gene. Diseases associated with GADD45B include metaphyseal chondrodysplasia, schmid type. Among its related pathways are MAPK signaling pathway and Chks in Checkpoint Regulation. An important paralog of this gene is GADD45G.

UniProtKB/Swiss-Prot for GADD45B Gene

  • Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK

Gene Wiki entry for GADD45B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GADD45B Gene

Genomics for GADD45B Gene

Regulatory Elements for GADD45B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GADD45B Gene

Chromosome:
19
Start:
2,476,122 bp from pter
End:
2,478,259 bp from pter
Size:
2,138 bases
Orientation:
Plus strand

Genomic View for GADD45B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GADD45B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GADD45B Gene

Proteins for GADD45B Gene

  • Protein details for GADD45B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75293-GA45B_HUMAN
    Recommended name:
    Growth arrest and DNA damage-inducible protein GADD45 beta
    Protein Accession:
    O75293
    Secondary Accessions:
    • A8KAM2
    • O75960
    • Q17R46

    Protein attributes for GADD45B Gene

    Size:
    160 amino acids
    Molecular mass:
    17818 Da
    Quaternary structure:
    • Interacts with GADD45GIP1.

neXtProt entry for GADD45B Gene

Proteomics data for GADD45B Gene at MOPED

Post-translational modifications for GADD45B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GADD45B Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for GADD45B

No data available for DME Specific Peptides for GADD45B Gene

Domains & Families for GADD45B Gene

Protein Domains for GADD45B Gene

Suggested Antigen Peptide Sequences for GADD45B Gene

Graphical View of Domain Structure for InterPro Entry

O75293

UniProtKB/Swiss-Prot:

GA45B_HUMAN :
  • Belongs to the GADD45 family.
Family:
  • Belongs to the GADD45 family.
genes like me logo Genes that share domains with GADD45B: view

No data available for Gene Families for GADD45B Gene

Function for GADD45B Gene

Molecular function for GADD45B Gene

GENATLAS Biochemistry:
growth arrest and DNA-damage-inducible,beta,ubiquitously expressed,activating MEKK4
UniProtKB/Swiss-Prot Function:
Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK

Gene Ontology (GO) - Molecular Function for GADD45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12052864
genes like me logo Genes that share ontologies with GADD45B: view
genes like me logo Genes that share phenotypes with GADD45B: view

Animal Models for GADD45B Gene

MGI Knock Outs for GADD45B:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GADD45B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for GADD45B Gene

Localization for GADD45B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GADD45B Gene COMPARTMENTS Subcellular localization image for GADD45B gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GADD45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9827804
GO:0005737 cytoplasm IDA 9827804
genes like me logo Genes that share ontologies with GADD45B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GADD45B Gene

Pathways & Interactions for GADD45B Gene

genes like me logo Genes that share pathways with GADD45B: view

PCR Array Products

Gene Ontology (GO) - Biological Process for GADD45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000185 activation of MAPKKK activity IDA 9827804
GO:0000186 activation of MAPKK activity IEA --
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0006915 apoptotic process IEA --
GO:0006950 response to stress IEA --
genes like me logo Genes that share ontologies with GADD45B: view

No data available for SIGNOR curated interactions for GADD45B Gene

Drugs & Compounds for GADD45B Gene

No Compound Related Data Available

Transcripts for GADD45B Gene

Unigene Clusters for GADD45B Gene

Growth arrest and DNA-damage-inducible, beta:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GADD45B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GADD45B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: - - - - -
SP5: - - -
SP6: - -
SP7: - -

Relevant External Links for GADD45B Gene

GeneLoc Exon Structure for
GADD45B
ECgene alternative splicing isoforms for
GADD45B

Expression for GADD45B Gene

mRNA expression in normal human tissues for GADD45B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for GADD45B Gene Hs.110571

genes like me logo Genes that share expression patterns with GADD45B: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GADD45B Gene

Orthologs for GADD45B Gene

This gene was present in the common ancestor of chordates.

Orthologs for GADD45B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GADD45B 35
  • 91.25 (n)
  • 96.87 (a)
GADD45B 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GADD45B 35
  • 92.5 (n)
  • 98.12 (a)
GADD45B 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gadd45b 35
  • 86.25 (n)
  • 93.12 (a)
Gadd45b 16
Gadd45b 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GADD45B 35
  • 99.58 (n)
  • 100 (a)
GADD45B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gadd45b 35
  • 85.42 (n)
  • 92.5 (a)
oppossum
(Monodelphis domestica)
Mammalia GADD45B 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GADD45B 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859853 35
  • 76.54 (n)
  • 76.85 (a)
GADD45B 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gadd45b 35
  • 62.24 (n)
  • 62.66 (a)
zebrafish
(Danio rerio)
Actinopterygii gadd45bb 35
  • 70.06 (n)
  • 71.34 (a)
sbcb196 35
gadd45ba 36
  • 69 (a)
OneToMany
gadd45bb 36
  • 69 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10915 35
Species with no ortholog for GADD45B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GADD45B Gene

ENSEMBL:
Gene Tree for GADD45B (if available)
TreeFam:
Gene Tree for GADD45B (if available)

Paralogs for GADD45B Gene

Paralogs for GADD45B Gene

(3) SIMAP similar genes for GADD45B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GADD45B: view

Variants for GADD45B Gene

Sequence variations from dbSNP and Humsavar for GADD45B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7354 -- 2,477,822(+) CGATC(A/C)GATGG utr-variant-3-prime
rs14384 -- 2,477,825(+) TCCGA(C/T)GGAGA utr-variant-3-prime
rs15306 -- 2,477,606(+) AGGCC(C/T)TTCCC utr-variant-3-prime
rs2024144 -- 2,477,279(+) CCCGC(C/T)ACGCC intron-variant
rs2302181 -- 2,477,817(+) GCCGC(C/T)GATCM utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GADD45B Gene

Variant ID Type Subtype PubMed ID
dgv3636n71 CNV Loss 21882294
dgv3637n71 CNV Loss 21882294
nsv910660 CNV Loss 21882294
nsv910668 CNV Loss 21882294

Variation tolerance for GADD45B Gene

Residual Variation Intolerance Score: 43.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.88; 96.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GADD45B Gene

HapMap Linkage Disequilibrium report
GADD45B
Human Gene Mutation Database (HGMD)
GADD45B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GADD45B Gene

Disorders for GADD45B Gene

MalaCards: The human disease database

(1) MalaCards diseases for GADD45B Gene - From: DISEASES

Disorder Aliases PubMed IDs
metaphyseal chondrodysplasia, schmid type
  • schmid metaphyseal chondrodysplasia
- elite association

Relevant External Links for GADD45B

Genetic Association Database (GAD)
GADD45B
Human Genome Epidemiology (HuGE) Navigator
GADD45B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GADD45B
genes like me logo Genes that share disorders with GADD45B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GADD45B Gene

Publications for GADD45B Gene

  1. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. (PMID: 9827804) Takekawa M. … Saito H. (Cell 1998) 2 23 67
  2. The antiapoptotic factor growth arrest and DNA-damage-inducible 45 beta regulates the nuclear receptor constitutive active/androstane receptor-mediated transcription. (PMID: 18362160) Yamamoto Y. … Negishi M. (Drug Metab. Dispos. 2008) 23 67
  3. GADD45B inhibits MKK7-induced cardiac hypertrophy and the polymorphisms of GADD45B is associated with inter-ventricular septum hypertrophy. (PMID: 18515079) Wang J. … Hui R. (Biochem. Biophys. Res. Commun. 2008) 23 67
  4. Antitumor activity of ALK1 in pancreatic carcinoma cells. (PMID: 17230504) Ungefroren H. … FAondrich F. (Int. J. Cancer 2007) 23 67
  5. Co-activation of ERK, NF-kappaB, and GADD45beta in response to ionizing radiation. (PMID: 15642734) Wang T. … Li J.J. (J. Biol. Chem. 2005) 23 67

Products for GADD45B Gene

Sources for GADD45B Gene

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