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Aliases for GADD45B Gene

Aliases for GADD45B Gene

  • Growth Arrest And DNA Damage Inducible Beta 2 3 5
  • Myeloid Differentiation Primary Response Protein MyD118 3 4
  • Growth Arrest And DNA-Damage-Inducible, Beta 2 3
  • Negative Growth Regulatory Protein MyD118 3 4
  • MYD118 3 4
  • Growth Arrest And DNA-Damage-Inducible Beta 2
  • Myeloid Differentiation Primary Response 2
  • GADD45BETA 3

External Ids for GADD45B Gene

Previous HGNC Symbols for GADD45B Gene

  • MYD118

Previous GeneCards Identifiers for GADD45B Gene

  • GC19P002538
  • GC19P002416
  • GC19P002427
  • GC19P002247

Summaries for GADD45B Gene

Entrez Gene Summary for GADD45B Gene

  • This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]

GeneCards Summary for GADD45B Gene

GADD45B (Growth Arrest And DNA Damage Inducible Beta) is a Protein Coding gene. Diseases associated with GADD45B include Metaphyseal Chondrodysplasia, Schmid Type. Among its related pathways are Chks in Checkpoint Regulation and BRCA1 Pathway. An important paralog of this gene is GADD45G.

UniProtKB/Swiss-Prot for GADD45B Gene

  • Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.

Gene Wiki entry for GADD45B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GADD45B Gene

Genomics for GADD45B Gene

Regulatory Elements for GADD45B Gene

Enhancers for GADD45B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GADD45B on UCSC Golden Path with GeneCards custom track

Promoters for GADD45B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GADD45B on UCSC Golden Path with GeneCards custom track

Genomic Location for GADD45B Gene

2,476,122 bp from pter
2,478,259 bp from pter
2,138 bases
Plus strand

Genomic View for GADD45B Gene

Genes around GADD45B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GADD45B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GADD45B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GADD45B Gene

Proteins for GADD45B Gene

  • Protein details for GADD45B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Growth arrest and DNA damage-inducible protein GADD45 beta
    Protein Accession:
    Secondary Accessions:
    • A8KAM2
    • O75960
    • Q17R46

    Protein attributes for GADD45B Gene

    160 amino acids
    Molecular mass:
    17818 Da
    Quaternary structure:
    • Interacts with GADD45GIP1.

neXtProt entry for GADD45B Gene

Proteomics data for GADD45B Gene at MOPED

Post-translational modifications for GADD45B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GADD45B Gene

No data available for DME Specific Peptides for GADD45B Gene

Domains & Families for GADD45B Gene

Protein Domains for GADD45B Gene

Suggested Antigen Peptide Sequences for GADD45B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GADD45 family.
  • Belongs to the GADD45 family.
genes like me logo Genes that share domains with GADD45B: view

No data available for Gene Families for GADD45B Gene

Function for GADD45B Gene

Molecular function for GADD45B Gene

GENATLAS Biochemistry:
growth arrest and DNA-damage-inducible,beta,ubiquitously expressed,activating MEKK4
UniProtKB/Swiss-Prot Function:
Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.
genes like me logo Genes that share phenotypes with GADD45B: view

Animal Models for GADD45B Gene

MGI Knock Outs for GADD45B:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GADD45B Gene

Localization for GADD45B Gene

Subcellular locations from

Jensen Localization Image for GADD45B Gene COMPARTMENTS Subcellular localization image for GADD45B gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 3
endosome 1
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GADD45B Gene

Pathways & Interactions for GADD45B Gene

genes like me logo Genes that share pathways with GADD45B: view

Gene Ontology (GO) - Biological Process for GADD45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000185 activation of MAPKKK activity IDA 9827804
GO:0000186 activation of MAPKK activity IEA --
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0006915 apoptotic process IEA --
GO:0006950 response to stress IEA --
genes like me logo Genes that share ontologies with GADD45B: view

No data available for SIGNOR curated interactions for GADD45B Gene

Drugs & Compounds for GADD45B Gene

No Compound Related Data Available

Transcripts for GADD45B Gene

Unigene Clusters for GADD45B Gene

Growth arrest and DNA-damage-inducible, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GADD45B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: - - - - -
SP5: - - -
SP6: - -
SP7: - -

Relevant External Links for GADD45B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GADD45B Gene

mRNA expression in normal human tissues for GADD45B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for GADD45B Gene Hs.110571

genes like me logo Genes that share expression patterns with GADD45B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GADD45B Gene

Orthologs for GADD45B Gene

This gene was present in the common ancestor of chordates.

Orthologs for GADD45B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GADD45B 35
  • 91.25 (n)
  • 96.87 (a)
GADD45B 36
  • 97 (a)
(Canis familiaris)
Mammalia GADD45B 35
  • 92.5 (n)
  • 98.12 (a)
GADD45B 36
  • 98 (a)
(Mus musculus)
Mammalia Gadd45b 35
  • 86.25 (n)
  • 93.12 (a)
Gadd45b 16
Gadd45b 36
  • 93 (a)
(Pan troglodytes)
Mammalia GADD45B 35
  • 99.58 (n)
  • 100 (a)
GADD45B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gadd45b 35
  • 85.42 (n)
  • 92.5 (a)
(Monodelphis domestica)
Mammalia GADD45B 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia GADD45B 36
  • 82 (a)
(Gallus gallus)
Aves LOC100859853 35
  • 76.54 (n)
  • 76.85 (a)
GADD45B 36
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gadd45b 35
  • 62.24 (n)
  • 62.66 (a)
(Danio rerio)
Actinopterygii gadd45bb 35
  • 70.06 (n)
  • 71.34 (a)
sbcb196 35
gadd45ba 36
  • 69 (a)
gadd45bb 36
  • 69 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10915 35
Species with no ortholog for GADD45B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GADD45B Gene

Gene Tree for GADD45B (if available)
Gene Tree for GADD45B (if available)

Paralogs for GADD45B Gene

Paralogs for GADD45B Gene

(3) SIMAP similar genes for GADD45B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GADD45B: view

Variants for GADD45B Gene

Sequence variations from dbSNP and Humsavar for GADD45B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs66934477 -- 2,478,756(+) CCCCA(-/G)CCCAC downstream-variant-500B
rs140354512 -- 2,478,225(+) TCTAC(C/T)ATGAG utr-variant-3-prime
rs140611154 -- 2,476,390(+) CGACA(A/G)CGCGG reference, missense
rs140956462 -- 2,475,064(+) GTTTC(C/T)CCTTT upstream-variant-2KB
rs9676893 -- 2,475,062(+) CAGTT(C/T)CCCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GADD45B Gene

Variant ID Type Subtype PubMed ID
dgv3636n71 CNV Loss 21882294
dgv3637n71 CNV Loss 21882294
nsv910660 CNV Loss 21882294
nsv910668 CNV Loss 21882294

Variation tolerance for GADD45B Gene

Residual Variation Intolerance Score: 44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.88; 96.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GADD45B Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GADD45B Gene

Disorders for GADD45B Gene

MalaCards: The human disease database

(1) MalaCards diseases for GADD45B Gene - From: DISEASES

Disorder Aliases PubMed IDs
metaphyseal chondrodysplasia, schmid type
  • smcd
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GADD45B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GADD45B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GADD45B Gene

Publications for GADD45B Gene

  1. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. (PMID: 9827804) Takekawa M. … Saito H. (Cell 1998) 2 3 4 23 67
  2. GADD45B inhibits MKK7-induced cardiac hypertrophy and the polymorphisms of GADD45B is associated with inter-ventricular septum hypertrophy. (PMID: 18515079) Wang J. … Hui R. (Biochem. Biophys. Res. Commun. 2008) 3 23
  3. Transforming growth factor-beta (TGF-beta) type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta. (PMID: 15546867) Ungefroren H. … FAondrich F. (J. Biol. Chem. 2005) 3 23
  4. Co-activation of ERK, NF-kappaB, and GADD45beta in response to ionizing radiation. (PMID: 15642734) Wang T. … Li J.J. (J. Biol. Chem. 2005) 3 23
  5. Hypermethylation of growth arrest DNA damage-inducible gene 45 beta promoter in human hepatocellular carcinoma. (PMID: 15509538) Qiu W. … Yen Y. (Am. J. Pathol. 2004) 3 23

Products for GADD45B Gene

Sources for GADD45B Gene