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Aliases for GADD45B Gene

Aliases for GADD45B Gene

  • Growth Arrest And DNA Damage Inducible Beta 2 3 5
  • Myeloid Differentiation Primary Response Protein MyD118 3 4
  • Negative Growth Regulatory Protein MyD118 3 4
  • MYD118 3 4
  • Growth Arrest And DNA Damage-Inducible Protein GADD45 Beta 3
  • Growth Arrest And DNA-Damage-Inducible, Beta 2
  • Growth Arrest And DNA-Damage-Inducible Beta 2
  • Myeloid Differentiation Primary Response 2
  • GADD45BETA 3

External Ids for GADD45B Gene

Previous HGNC Symbols for GADD45B Gene

  • MYD118

Previous GeneCards Identifiers for GADD45B Gene

  • GC19P002538
  • GC19P002416
  • GC19P002427
  • GC19P002247

Summaries for GADD45B Gene

Entrez Gene Summary for GADD45B Gene

  • This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]

GeneCards Summary for GADD45B Gene

GADD45B (Growth Arrest And DNA Damage Inducible Beta) is a Protein Coding gene. Diseases associated with GADD45B include Metaphyseal Chondrodysplasia, Schmid Type. Among its related pathways are ATM Pathway and DNA damage response. An important paralog of this gene is GADD45A.

UniProtKB/Swiss-Prot for GADD45B Gene

  • Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.

Gene Wiki entry for GADD45B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GADD45B Gene

Genomics for GADD45B Gene

Regulatory Elements for GADD45B Gene

Enhancers for GADD45B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F002615 1.6 FANTOM5 Ensembl ENCODE 24.3 +151.5 151504 24.4 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 GADD45B SF3A2 GNG7 DIRAS1 LOC100288123 CACTIN-AS1 RNU6-993P SLC39A3 C19orf35 LOC101928631
GH19F002160 0.9 FANTOM5 ENCODE 24.2 -308.4 -308382 13.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 ZNF77 GADD45B DOT1L LOC100288123 SF3A2 ZNF554 ENSG00000267139 CIRBP ENSG00000267317 ADAT3
GH19F002548 1.6 FANTOM5 Ensembl ENCODE 21.4 +75.1 75080 4.8 HDAC1 PKNOX1 NFRKB RAD21 YY1 ZNF335 ZNF766 ELK1 GATA2 ETV6 GADD45B SF3A2 DOT1L ENSG00000261526 GC19P002552 PIR51282
GH19F002474 1 FANTOM5 ENCODE 16.8 +1.3 1313 5.6 MLX YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 ZFP41 SSRP1 ZNF77 SF3A2 GADD45B ZNF555 LOC100288123 ENSG00000261526 ZNF554 DOT1L TIMM13 LOC101928631
GH19F002506 1.5 FANTOM5 Ensembl ENCODE 15.1 +31.3 31335 1.9 PKNOX1 MLX ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 FOS SP3 GADD45B DOT1L C19orf35 OAZ1 RNU6-993P LOC101929097
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GADD45B on UCSC Golden Path with GeneCards custom track

Promoters for GADD45B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000341804 878 5201 MLX YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 ZFP41 SSRP1

Genomic Location for GADD45B Gene

Chromosome:
19
Start:
2,476,122 bp from pter
End:
2,478,259 bp from pter
Size:
2,138 bases
Orientation:
Plus strand

Genomic View for GADD45B Gene

Genes around GADD45B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GADD45B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GADD45B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GADD45B Gene

Proteins for GADD45B Gene

  • Protein details for GADD45B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75293-GA45B_HUMAN
    Recommended name:
    Growth arrest and DNA damage-inducible protein GADD45 beta
    Protein Accession:
    O75293
    Secondary Accessions:
    • A8KAM2
    • O75960
    • Q17R46

    Protein attributes for GADD45B Gene

    Size:
    160 amino acids
    Molecular mass:
    17818 Da
    Quaternary structure:
    • Interacts with GADD45GIP1.

neXtProt entry for GADD45B Gene

Post-translational modifications for GADD45B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GADD45B Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for GADD45B

No data available for DME Specific Peptides for GADD45B Gene

Domains & Families for GADD45B Gene

Protein Domains for GADD45B Gene

Suggested Antigen Peptide Sequences for GADD45B Gene

Graphical View of Domain Structure for InterPro Entry

O75293

UniProtKB/Swiss-Prot:

GA45B_HUMAN :
  • Belongs to the GADD45 family.
Family:
  • Belongs to the GADD45 family.
genes like me logo Genes that share domains with GADD45B: view

No data available for Gene Families for GADD45B Gene

Function for GADD45B Gene

Molecular function for GADD45B Gene

GENATLAS Biochemistry:
growth arrest and DNA-damage-inducible,beta,ubiquitously expressed,activating MEKK4
UniProtKB/Swiss-Prot Function:
Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.

Gene Ontology (GO) - Molecular Function for GADD45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12052864
genes like me logo Genes that share ontologies with GADD45B: view
genes like me logo Genes that share phenotypes with GADD45B: view

Animal Models for GADD45B Gene

MGI Knock Outs for GADD45B:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GADD45B Gene

Localization for GADD45B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GADD45B Gene COMPARTMENTS Subcellular localization image for GADD45B gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 3
endosome 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GADD45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9827804
GO:0005737 cytoplasm IDA 9827804
genes like me logo Genes that share ontologies with GADD45B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GADD45B Gene

Pathways & Interactions for GADD45B Gene

genes like me logo Genes that share pathways with GADD45B: view

Gene Ontology (GO) - Biological Process for GADD45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000185 activation of MAPKKK activity IDA 9827804
GO:0000186 activation of MAPKK activity IEA --
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0006915 apoptotic process IEA --
GO:0006950 response to stress IEA --
genes like me logo Genes that share ontologies with GADD45B: view

No data available for SIGNOR curated interactions for GADD45B Gene

Transcripts for GADD45B Gene

Unigene Clusters for GADD45B Gene

Growth arrest and DNA-damage-inducible, beta:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GADD45B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: - - - - -
SP5: - - -
SP6: - -
SP7: - -

Relevant External Links for GADD45B Gene

GeneLoc Exon Structure for
GADD45B
ECgene alternative splicing isoforms for
GADD45B

Expression for GADD45B Gene

mRNA expression in normal human tissues for GADD45B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of GADD45B Gene:

GADD45B

SOURCE GeneReport for Unigene cluster for GADD45B Gene:

Hs.110571
genes like me logo Genes that share expression patterns with GADD45B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for GADD45B Gene

Orthologs for GADD45B Gene

This gene was present in the common ancestor of chordates.

Orthologs for GADD45B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GADD45B 34 35
  • 99.58 (n)
dog
(Canis familiaris)
Mammalia GADD45B 34 35
  • 92.5 (n)
cow
(Bos Taurus)
Mammalia GADD45B 34 35
  • 91.25 (n)
mouse
(Mus musculus)
Mammalia Gadd45b 34 16 35
  • 86.25 (n)
oppossum
(Monodelphis domestica)
Mammalia GADD45B 35
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gadd45b 34
  • 85.42 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GADD45B 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859853 34
  • 76.54 (n)
GADD45B 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gadd45b 34
  • 62.24 (n)
zebrafish
(Danio rerio)
Actinopterygii gadd45bb 34 35
  • 70.06 (n)
gadd45ba 35
  • 69 (a)
OneToMany
sbcb196 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10915 34
Species where no ortholog for GADD45B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GADD45B Gene

ENSEMBL:
Gene Tree for GADD45B (if available)
TreeFam:
Gene Tree for GADD45B (if available)

Paralogs for GADD45B Gene

Paralogs for GADD45B Gene

(3) SIMAP similar genes for GADD45B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GADD45B: view

Variants for GADD45B Gene

Sequence variations from dbSNP and Humsavar for GADD45B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10536868 -- 2,478,373(+) AGCCC(-/CT)GTTAG downstream-variant-500B
rs111265274 -- 2,476,278(+) AGGTT(G/T)TGGGC utr-variant-5-prime
rs111297878 -- 2,477,948(+) ACTGT(C/G)CACTC utr-variant-3-prime
rs111300301 -- 2,475,311(+) CCGCA(C/T)GGGCA upstream-variant-2KB
rs111939716 -- 2,476,111(+) GGTGC(C/G)GGAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GADD45B Gene

Variant ID Type Subtype PubMed ID
nsv1064930 CNV gain 25217958
nsv953944 CNV deletion 24416366

Variation tolerance for GADD45B Gene

Residual Variation Intolerance Score: 44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.88; 96.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GADD45B Gene

Human Gene Mutation Database (HGMD)
GADD45B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GADD45B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GADD45B Gene

Disorders for GADD45B Gene

MalaCards: The human disease database

(1) MalaCards diseases for GADD45B Gene - From: DISEASES

Disorder Aliases PubMed IDs
metaphyseal chondrodysplasia, schmid type
  • corneal dystrophy, subepithelial mucinous
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GADD45B

Genetic Association Database (GAD)
GADD45B
Human Genome Epidemiology (HuGE) Navigator
GADD45B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GADD45B
genes like me logo Genes that share disorders with GADD45B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GADD45B Gene

Publications for GADD45B Gene

  1. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. (PMID: 9827804) Takekawa M. … Saito H. (Cell 1998) 2 3 4 22 64
  2. GADD45B inhibits MKK7-induced cardiac hypertrophy and the polymorphisms of GADD45B is associated with inter-ventricular septum hypertrophy. (PMID: 18515079) Wang J. … Hui R. (Biochem. Biophys. Res. Commun. 2008) 3 22 64
  3. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PMID: 19064572) Palmieri R.T. … . (Cancer Epidemiol. Biomarkers Prev. 2008) 3 46 64
  4. Transforming growth factor-beta (TGF-beta) type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta. (PMID: 15546867) Ungefroren H. … FAondrich F. (J. Biol. Chem. 2005) 3 22 64
  5. Co-activation of ERK, NF-kappaB, and GADD45beta in response to ionizing radiation. (PMID: 15642734) Wang T. … Li J.J. (J. Biol. Chem. 2005) 3 22 64

Products for GADD45B Gene

Sources for GADD45B Gene

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