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Aliases & Descriptions for GADD45B
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DKFZP566B133 1 | | DKFZp566B133 2 | | GADD45BETA 1, 2 | | MYD118 2, 3, 5 |
| | | Descriptions |
|---|
| Myeloid differentiation primary response protein MyD118 3 | | Negative growth regulatory protein MyD118 3 | | growth arrest and DNA-damage-inducible, beta 2 | | myeloid differentiation primary response 2 |
|
| | Search outside databases for aliases for GADD45B genePrevious GC identifers: GC19P002538 GC19P002416 |
Summaries for GADD45B(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for GADD45B: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq] UniProtKB/Swiss-Prot: GA45B_HUMAN, O75293Function: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKKGene Wiki entry for GADD45B |
Genomic Location for GADD45B
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the GADD45B gene 
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3GADD45B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P002427:
(about GC identifiers)
Start:
|
2,427,135 bp from pter |
End:
|
2,429,257 bp from pter |
Size:
|
2,123 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011255.14
| Proteins for GADD45B
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: GA45B_HUMAN, O75293 (See
protein sequence)Recommended Name: Growth arrest and DNA-damage-inducible protein GADD45 beta Size: 160 amino acids; 17818 Da
Subunit: Interacts with GADD45GIP1
Secondary accessions: O75960 Q17R46REFSEQ proteins: NP_056490.2
ENSEMBL proteins: ENSP00000215631
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
Antibodies for GADD45B: Assays for GADD45B: | Protein
Domains/ Families for GADD45B(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O75293
ProtoNet protein and cluster: O75293 1 Blocks protein family: IPB004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45
UniProtKB/Swiss-Prot: GA45B_HUMAN, O75293Similarity: Belongs to the GADD45 family | Gene Function for GADD45B
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015675
Applied Biosystems Silencer® siRNAs for GADD45B
Sigma-Aldrich siRNA for GADD45B  Sigma-Aldrich shRNA Panels and shRNA for GADD45B  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015675                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015675                                  untagged cDNA clone in CMV expression vector: NM_015675 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_015675
UniProtKB/Swiss-Prot: GA45B_HUMAN, O75293Function: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKKGenatlas biochemistry entry for GADD45B:growth arrest and DNA-damage-inducible,beta,ubiquitously expressed,activating MEKK44 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Gadd45b):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IEA | -- | About this table | Pathways & Interactions for GADD45B
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Sigma-Aldrich "Your Favorite Gene" Pathways for GADD45B (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for GADD45B 
5/38 Interacting proteins for GADD45B (O752932 ENSP000002156313) via UniProtKB, MINT, and/or STRING (see all 38
)About this table
5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8
): About this table
|
Drugs & Compounds for GADD45B(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for GADD45B
|
Transcripts for GADD45B(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015675
Sigma-Aldrich siRNA for GADD45B  Sigma-Aldrich shRNA Panels and shRNA for GADD45B  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_015675 REFSEQ mRNAs for GADD45B gene: NM_015675.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_015675               OriGene GFP tagged cDNA clone in CMV expression vector: NM_015675                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015675                                  untagged cDNA clone in CMV expression vector: NM_015675  Additional cDNA sequence: AF078077.1 AF087853.1 AK293087.1 AL050044.1 AY615270.1 AY615271.1 BC024654.3 BC113466.1 BC117469.1 10 DOTS entries: DT.102827445 DT.97855933 DT.95267656 DT.121475454 DT.91924709 DT.97769928 DT.97855934 DT.121475448 DT.121475457 DT.40306306 24/603 AceView cDNA sequences (see all 603
):AA429118 BM708634 BM991001 BM748511 BQ723443 BM757579 BM748552 BM749738 BM750581 CB131148 BM692252 BM748565 BM829409 AA806506 BM758264 BM758994 BM757977 BU168386 BM670459 BM749736 BM757667 AA402108 CA306845 BM787036
highest scoring ESTs for GADD45B:AF078077 AA004360 AA018764 AA039363 AA039364 AA056235 AA069206 AA113188 AA194909 AA203558 Unigene Cluster for GADD45B: Growth arrest and DNA-damage-inducible, beta Hs.110571 [show with all ESTs]Unigene Representative Sequence: AF087853
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GADD45B (see all 7
)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d | |
| SP1: | |   | |   | - |   | - |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | - |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP5: | |   | |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for GADD45B
1 Ensembl transcript including schematic representation: ENST00000215631
|
Expression for GADD45B
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| GADD45B expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for GADD45B
1 / 2 / 3 7 probe-sets matching GADD45B gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AACTCCCAGT
SOURCE GeneReport for Unigene cluster: Hs.110571
Expression variation in blood from EXPOLDB for GADD45B |
Orthologs for GADD45B
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GADD45B gene from 5/7 species (see all 7
)
About this table Species with no ortholog for GADD45B
ENSEMBL Gene Tree for GADD45B | Paralogs for GADD45B(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for GADD45B gene
- GADD45G2 GADD45A2
|
SNPs/Variants for GADD45B(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
The following additional 31 SNP(s) have been
found in Applied Biosystems data source: (Click
for
Applied Biosystems TaqMan ® Genotyping Assay)
HapMap Linkage Disequilibrium images for GADD45B (up to first 250kb)
|
Disorders & Mutations for GADD45B
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604948
2 Novoseek disease relationships for GADD45B gene
About this table
Human Genome Epidemiology Navigator: GADD45B (1 document)
|
Medical News for GADD45B(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for GADD45B (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/52 PubMed articles for GADD45B gene (see all 52
):- A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. (PubMed id 9827804)1, 2, 3, 4 Takekawa M. and Saito H. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)3, 4 Grimwood J.... Lucas S.M. (2004)
- CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle. (PubMed id 12716909)3, 4 Chung H.K.... Shong M. (2003)
- Assignment of human GADD45G to chromosome 9q22.1-->q22.3 by radiation hybrid mapping. (PubMed id 10773677)3, 4 Gong R.... Zhao S. (2000)
- Sequence and expression of a cDNA encoding MyD118: a novel myeloid differentiation primary response gene induced by multiple cytokines. (PubMed id 1899477)2, 3 Abdollahi A....Liebermann D.A. (1991)
- The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1. (PubMed id 8700517)1, 3 Vairapandi M....Liebermann D.A. (1996)
- Characterization of MyD118, Gadd45, and proliferating cell nuclear antigen (PCNA) interacting domains. PCNA impedes MyD118 AND Gadd45-mediated negative growth control. (PubMed id 10828065)1, 3 Vairapandi M....Liebermann D.A. (2000)
- Hypermethylation of growth arrest DNA damage-inducible gene 45 beta promoter in human hepatocellular carcinoma. (PubMed id 15509538)1, 3 Qiu W....Yen Y. (2004)
- Transforming growth factor-beta (TGF-beta) type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta. (PubMed id 15546867)1, 3 Ungefroren H....Fandrich F. (2005)
|
Search for GADD45B
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing GADD45B
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing GADD45B
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GADD45B(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for GADD45B(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for GADD45B:

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Incremental update: 13 Oct 2009
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