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Aliases for GADD45B Gene

Aliases for GADD45B Gene

  • Growth Arrest And DNA Damage Inducible Beta 2 3 5
  • Myeloid Differentiation Primary Response Protein MyD118 3 4
  • Negative Growth Regulatory Protein MyD118 3 4
  • MYD118 3 4
  • Growth Arrest And DNA Damage-Inducible Protein GADD45 Beta 3
  • Growth Arrest And DNA-Damage-Inducible, Beta 2
  • Growth Arrest And DNA-Damage-Inducible Beta 2
  • Myeloid Differentiation Primary Response 2
  • GADD45BETA 3

External Ids for GADD45B Gene

Previous HGNC Symbols for GADD45B Gene

  • MYD118

Previous GeneCards Identifiers for GADD45B Gene

  • GC19P002538
  • GC19P002416
  • GC19P002427
  • GC19P002247

Summaries for GADD45B Gene

Entrez Gene Summary for GADD45B Gene

  • This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]

GeneCards Summary for GADD45B Gene

GADD45B (Growth Arrest And DNA Damage Inducible Beta) is a Protein Coding gene. Diseases associated with GADD45B include Metaphyseal Chondrodysplasia, Schmid Type and Short-Rib Thoracic Dysplasia 5 With Or Without Polydactyly. Among its related pathways are Development_TGF-beta receptor signaling and Endometrial cancer. An important paralog of this gene is GADD45G.

UniProtKB/Swiss-Prot for GADD45B Gene

  • Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.

Gene Wiki entry for GADD45B Gene

Additional gene information for GADD45B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GADD45B Gene

Genomics for GADD45B Gene

Regulatory Elements for GADD45B Gene

Enhancers for GADD45B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H002160 1.8 FANTOM5 ENCODE dbSUPER 24.2 -308.4 -308382 13.7 MLX FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MEF2D GLIS1 ZNF77 DOT1L AP3D1 CIRBP GADD45B DAZAP1 LOC100288123 SF3A2 ZNF554 TCF3
GH19H002549 1.5 FANTOM5 Ensembl ENCODE dbSUPER 21.4 +74.1 74116 2.2 CTCF ZMYM3 MAX NR2F2 GABPA YY1 CBX1 POLR2A IKZF1 KDM1A GADD45B DOT1L ENSG00000261526 GC19P002552 PIR51282
GH19H002506 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15.1 +31.0 31035 1.3 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 ZNF2 YY1 FOS SP3 GADD45B DOT1L PEAK3 OAZ1 RNU6-993P LOC101929097
GH19H002474 1.7 FANTOM5 ENCODE dbSUPER 16.8 +1.3 1313 5.6 MLX YY1 SLC30A9 ZNF143 SP3 NFYC ZFP41 SSRP1 ZNF610 GLIS1 SF3A2 TCF3 LOC100288123 ZNF77 GADD45B ZNF554 ENSG00000267139 MBD3 ENSG00000267283 DOT1L
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GADD45B on UCSC Golden Path with GeneCards custom track

Promoters for GADD45B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000105872 878 4801 MLX YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 ZNF610 GLIS1 RCOR2

Genomic Locations for GADD45B Gene

Genomic Locations for GADD45B Gene
2,138 bases
Plus strand

Genomic View for GADD45B Gene

Genes around GADD45B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GADD45B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GADD45B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GADD45B Gene

Proteins for GADD45B Gene

  • Protein details for GADD45B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Growth arrest and DNA damage-inducible protein GADD45 beta
    Protein Accession:
    Secondary Accessions:
    • A8KAM2
    • O75960
    • Q17R46

    Protein attributes for GADD45B Gene

    160 amino acids
    Molecular mass:
    17818 Da
    Quaternary structure:
    • Interacts with GADD45GIP1.

neXtProt entry for GADD45B Gene

Post-translational modifications for GADD45B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GADD45B Gene

No data available for DME Specific Peptides for GADD45B Gene

Domains & Families for GADD45B Gene

Gene Families for GADD45B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GADD45B Gene

Suggested Antigen Peptide Sequences for GADD45B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GADD45 family.
  • Belongs to the GADD45 family.
genes like me logo Genes that share domains with GADD45B: view

Function for GADD45B Gene

Molecular function for GADD45B Gene

GENATLAS Biochemistry:
growth arrest and DNA-damage-inducible,beta,ubiquitously expressed,activating MEKK4
UniProtKB/Swiss-Prot Function:
Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.

Phenotypes From GWAS Catalog for GADD45B Gene

Gene Ontology (GO) - Molecular Function for GADD45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12052864
genes like me logo Genes that share ontologies with GADD45B: view
genes like me logo Genes that share phenotypes with GADD45B: view

Animal Models for GADD45B Gene

MGI Knock Outs for GADD45B:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GADD45B Gene

Localization for GADD45B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GADD45B gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 3
plasma membrane 1
mitochondrion 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GADD45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9827804
GO:0005737 cytoplasm IDA 9827804
genes like me logo Genes that share ontologies with GADD45B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GADD45B Gene

Pathways & Interactions for GADD45B Gene

genes like me logo Genes that share pathways with GADD45B: view

Gene Ontology (GO) - Biological Process for GADD45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000185 activation of MAPKKK activity IDA 9827804
GO:0000186 activation of MAPKK activity IEA --
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0006915 apoptotic process IEA --
GO:0006950 response to stress IEA --
genes like me logo Genes that share ontologies with GADD45B: view

No data available for SIGNOR curated interactions for GADD45B Gene

Drugs & Compounds for GADD45B Gene

No Compound Related Data Available

Transcripts for GADD45B Gene

Unigene Clusters for GADD45B Gene

Growth arrest and DNA-damage-inducible, beta:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GADD45B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: - - - - -
SP5: - - -
SP6: - -
SP7: - -

Relevant External Links for GADD45B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GADD45B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GADD45B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of GADD45B Gene:


SOURCE GeneReport for Unigene cluster for GADD45B Gene:


Evidence on tissue expression from TISSUES for GADD45B Gene

  • Nervous system(4.8)
  • Lung(4.1)
  • Liver(3.4)
  • Bone marrow(3)
  • Spleen(3)
  • Intestine(2.9)
  • Heart(2.8)
  • Kidney(2.5)
  • Muscle(2.5)
  • Blood(2.4)
  • Eye(2.4)
  • Lymph node(2.4)
genes like me logo Genes that share expression patterns with GADD45B: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GADD45B Gene

Orthologs for GADD45B Gene

This gene was present in the common ancestor of chordates.

Orthologs for GADD45B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GADD45B 33 34
  • 99.58 (n)
(Canis familiaris)
Mammalia GADD45B 33 34
  • 92.5 (n)
(Bos Taurus)
Mammalia GADD45B 33 34
  • 91.25 (n)
(Mus musculus)
Mammalia Gadd45b 33 16 34
  • 86.25 (n)
(Monodelphis domestica)
Mammalia GADD45B 34
  • 86 (a)
(Rattus norvegicus)
Mammalia Gadd45b 33
  • 85.42 (n)
(Ornithorhynchus anatinus)
Mammalia GADD45B 34
  • 82 (a)
(Gallus gallus)
Aves LOC100859853 33
  • 76.54 (n)
GADD45B 34
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gadd45b 33
  • 62.24 (n)
(Danio rerio)
Actinopterygii gadd45bb 33 34
  • 70.06 (n)
gadd45ba 34
  • 69 (a)
sbcb196 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10915 33
Species where no ortholog for GADD45B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GADD45B Gene

Gene Tree for GADD45B (if available)
Gene Tree for GADD45B (if available)

Paralogs for GADD45B Gene

Paralogs for GADD45B Gene

(3) SIMAP similar genes for GADD45B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GADD45B: view

Variants for GADD45B Gene

Sequence variations from dbSNP and Humsavar for GADD45B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000209599 -- 2,476,952(+) GCTCC(-/T)TTTTT intron-variant
rs1001844202 -- 2,475,327(+) TGGAA(C/T)GCCAG upstream-variant-2KB
rs1002083496 -- 2,474,870(+) AGGCT(G/T)GCGGG upstream-variant-2KB
rs1002445430 -- 2,476,211(+) TCCGC(C/T)TTTTC utr-variant-5-prime
rs1004034755 -- 2,477,677(+) CTCCC(C/T)CCCAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GADD45B Gene

Variant ID Type Subtype PubMed ID
nsv953944 CNV deletion 24416366
nsv1064930 CNV gain 25217958

Variation tolerance for GADD45B Gene

Residual Variation Intolerance Score: 44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.88; 96.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GADD45B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GADD45B Gene

Disorders for GADD45B Gene

MalaCards: The human disease database

(2) MalaCards diseases for GADD45B Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
metaphyseal chondrodysplasia, schmid type
  • schmid metaphyseal chondrodysplasia
short-rib thoracic dysplasia 5 with or without polydactyly
  • asphyxiating thoracic dystrophy 5
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GADD45B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GADD45B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GADD45B Gene

Publications for GADD45B Gene

  1. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. (PMID: 9827804) Takekawa M … Saito H (Cell 1998) 2 3 4 22 60
  2. GADD45B inhibits MKK7-induced cardiac hypertrophy and the polymorphisms of GADD45B is associated with inter-ventricular septum hypertrophy. (PMID: 18515079) Wang J … Hui R (Biochemical and biophysical research communications 2008) 3 22 60
  3. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PMID: 19064572) Palmieri RT … Australian Ovarian Cancer Study Group (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 45 60
  4. Transforming growth factor-beta (TGF-beta) type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta. (PMID: 15546867) Ungefroren H … Fändrich F (The Journal of biological chemistry 2005) 3 22 60
  5. Co-activation of ERK, NF-kappaB, and GADD45beta in response to ionizing radiation. (PMID: 15642734) Wang T … Li JJ (The Journal of biological chemistry 2005) 3 22 60

Products for GADD45B Gene

Sources for GADD45B Gene

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