V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

GADD45A Gene

protein-coding GIFtS: 65

GC01P067862

growth arrest and DNA-damage-inducible, alpha
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: DDIT1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DDIT-1 ^³
DDIT1 ^², ³
GADD45 ^¹, ², ³
OTTHUMP00000010979 ^²

Descriptions
DNA damage-inducible transcript 1 ^²
DNA damage-inducible transcript-1 ^²
DNA-damage-inducible transcript 1 ^², ³
growth arrest and DNA-damage-inducible 45 alpha ^²
growth arrest and DNA-damage-inducible, alpha ^²

External Ids
HGNC: 4095¹
Entrez Gene: 1647²
UniProtKB: P24522³
Ensembl: ENSG00000116717⁷

Search outside databases for aliases for GADD45A gene

Previous GC identifers: GC01P068111 GC01P067082 GC01P067508 GC01P067520

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GADD45A:

This gene is a member of a group of genes whose transcript levels are increased following stressful

growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene

responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4

kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and

-independent mechanisms. [provided by RefSeq]

UniProtKB/Swiss-Prot: GA45A_HUMAN, P24522

Function: Binds to proliferating cell nuclear antigen. Might affect PCNA interaction with some CDK

(cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits

entry of cells into S phase

Gene Wiki entry for GADD45A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GADD45A gene

Entrez Gene cytogenetic band: 1p31.2-p31.1 Ensembl cytogenetic band: 1p31.3 HGNC cytogenetic band: 1p31.2

GADD45A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P067862: (about GC identifiers)

Start:	67,923,471 bp from pter
End:	67,926,607 bp from pter
Size:	3,137 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: GA45A_HUMAN, P24522 (See protein sequence)

Recommended Name: Growth arrest and DNA-damage-inducible protein GADD45 alpha

Size: 165 amino acids; 18336 Da

Subunit: Interacts with GADD45GIP1

PDB structures from and Proteopedia :

2KG4 (3D)

REFSEQ proteins: NP_001915.1

ENSEMBL proteins:

ENSP00000360024 ENSP00000360025

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GADD45A)
	Human Recombinant Proteins from Abnova (GADD45A)

OriGene Purified Recombinant Human Protein: GADD45A

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	7798274

About this table

Antibodies for GADD45A:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of GADD45A
	Sigma-Aldrich Antibodies for GADD45A
	R&D Systems Antibodies for GADD45A (GADD45 alpha)
	Antibodies from Abcam (GADD45A), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GADD45A)
	Novus Biologicals Antibodies for GADD45A

Assays for GADD45A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P24522

ProtoNet protein and cluster: P24522

1 Blocks protein family: IPB004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45

UniProtKB/Swiss-Prot: GA45A_HUMAN, P24522

Similarity: Belongs to the GADD45 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GADD45A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GADD45A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001924

Applied Biosystems Silencer® siRNAs for GADD45A

Sigma-Aldrich siRNA and siRNA Panels for GADD45A

Sigma-Aldrich shRNA Panels and shRNA for GADD45A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GADD45A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001924
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001924
untagged cDNA clone in CMV expression vector: NM_001924

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001924

UniProtKB/Swiss-Prot: GA45A_HUMAN, P24522

Function: Binds to proliferating cell nuclear antigen. Might affect PCNA interaction with some CDK

(cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits

entry of cells into S phase

Induction: By UV radiation, X-rays, growth arrest and alkylating agents. The induction is mediate

by some kinase(s) other than PKC

Genatlas biochemistry entry for GADD45A:

growth arrest and DNA-damage-inducible transcript alpha,involved in UV- and methyl methanisulfonate

(MMS)-induced G2 arrest,p53-responsive stress protein activating MEKK4,interacting with the four

core histones,mediating G2/M checkpoint,down-regulated by cyclin B1 and Cdc25C

expression,inactivating (M phase promoting factor) MPF through interaction with CDC2 but not

cyclin B1,putative downregulated c-Myc target gene,modifying DNA accessibility on damaged

chromatin

10 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Gadd45a):

cellular	hematopoietic system	homeostasis/metabolism	immune system	life span-post-weaning/aging
nervous system	renal/urinary system	reproductive system	skin/coat/nails	tumorigenesis

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for GADD45A (Your Favorite Gene powered by Ingenuity) (see all 6 )

ATM Signaling
Role of BRCA1 in DNA Damage Response
SAPK/JNK Signaling
VDR/RXR Activation
p53 Signaling

GeneDecks GADD45A for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for GADD45A

5/80 Interacting proteins for GADD45A (P24522^{1, 2} ENSP00000360025³) via UniProtKB, MINT, and/or STRING (see all 80 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GADD45GIP1	Q8TAE8¹^,², ENSP00000323065³	EBI-448167, EBI-372506 MINT-16447 MINT-16448 MINT-16446 EBI-448167, EBI-372506 MINT-16447 MINT-16448 MINT-16446 STRING (score=.872)
GADD45GIP1 GADD45GIP1 (xeno)	Q8SPE7¹	EBI-448167, EBI-2267139
GADD45GIP1	Q8TAE8¹^,², ENSP00000323065³	EBI-448167, EBI-372506 MINT-16447 MINT-16448 MINT-16446 EBI-448167, EBI-372506 MINT-16447 MINT-16448 MINT-16446 STRING (score=.872)
DCTN2	Q13561²	MINT-66121
FTL	P02792²	MINT-63357

About this table

5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000079	regulation of cyclin-dependent protein kinase activity	TAS	10747892
GO:0000086	G2/M transition of mitotic cell cycle	IEA	--
GO:0006281	DNA repair	TAS	7973727
GO:0006469	negative regulation of protein kinase activity	IEA	--
GO:0006915	apoptosis	TAS	10828065

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GADD45A
10/14 Novoseek chemical compound relationships for GADD45A gene (see all 14 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mnng	29.21	6	11516527 (3), 8649801 (2)
pd 98,059	21.10	2	15064713 (1), 12406558 (1)
deferoxamine	15.93	5	10397746 (4)
selenium	8.78	6	19276161 (1), 15203190 (1), 9174104 (1)
calcium	3.10	2	8184014 (2)
leucine	1.40	2	18849615 (1)
thymidine	0.45	2	16892554 (1), 16243820 (1)
threonine	0.22	1	12406558 (1)
oxygen	0.00	2	19041686 (1)
iron	0.00	4	10397746 (2), 10560945 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GADD45A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GADD45A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001924

Sigma-Aldrich siRNA and siRNA Panels for GADD45A

Sigma-Aldrich shRNA Panels and shRNA for GADD45A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001924

REFSEQ mRNAs for GADD45A gene:

NM_001924.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001924

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001924
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001924
                                 untagged cDNA clone in CMV expression vector: NM_001924

Additional cDNA sequence:

AK314991.1 BC011757.2 CR608507.1 CR609553.1 CR611787.1 CR612467.1 CR612719.1 CR613302.1

CR623510.1 DQ008445.1 EF581092.1 EF614238.1 M60974.1

7 DOTS entries:

DT.114884 DT.114885 DT.95226036 DT.121441466 DT.95374637 DT.100743098 DT.95374636

24/185 AceView cDNA sequences (see all 185 ):

AW014421 BF939687 BC011757 BG575117 BM999387 CD365249 NM_001924 BQ575818

BF033052 CR623510 CA412788 BX090426 CR612719 AU126574 CA748690 M60974

BP374942 CR611787 BF726789 CB045463 CR608507 BF726748 BE857043 BU632621

highest scoring ESTs for GADD45A:

M60974 AA036953 AA136799 AA136869 AA147214 AA494367 AA700593 AA931261 AA931403 AA992456

Unigene Cluster for GADD45A:

Growth arrest and DNA-damage-inducible, alpha

Hs.80409 [show with all ESTs]

Unigene Representative Sequence: CR612719

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for GADD45A

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4a	·	4b
SP1:									-
SP2:							-		-
SP3:

About this scheme

ECgene alternative splicing isoforms for GADD45A

2 Ensembl transcripts including schematic representations:

ENST00000370985 ENST00000370986

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GADD45A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GADD45A

¹ / ² / ³

3 probe-sets matching GADD45A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1911_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M60974	1.00	1.00	1.00	1
203725_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001924	0.60	1.00	0.82	1
203725_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks GADD45A for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAAAGTTATT

SOURCE GeneReport for Unigene cluster: Hs.80409
Expression variation in blood from EXPOLDB for GADD45A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GADD45A gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	GADD45A¹	--	growth arrest and DNA-damage-inducible, alpha	100(n) 100(a)	456929 XM_513476.2 XP_513476.2
cow (Bos taurus)	GADD45A¹	--	growth arrest and DNA-damage-inducible, alpha	94.14(n) 99.39(a)	505463 NM_001034247.1 NP_001029419.1
rat (Rattus norvegicus)	Gadd45a¹	--	growth arrest and DNA-damage-inducible, alpha	87.88(n) 92.73(a)	25112 NM_024127.2 NP_077041.2
mouse (Mus musculus)	Gadd45a^{1, 5}	6⁵	growth arrest and DNA-damage-inducible 45 alpha^{1, 5}	90.51(n)¹ 94.55(a)¹	13197¹ NM_007836.1¹ NP_031862.1¹ AA545191⁵ AK144900⁵ (see all 10)
zebrafish (Danio rerio)	Dr.14374²	--	Transcribed sequence with weak similarity to protein more	77.42(n)	CK029593.1

About this table Species with no ortholog for GADD45A

ENSEMBL Gene Tree for GADD45A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GADD45A gene

GADD45B² GADD45G²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/50 NCBI SNPs in GADD45A are shown (see all 50 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 54)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs607375^1,2	A,C,F,H,O	67926674(-)	`GTATAG/CAGCAA`	1	--	ng3¹		13	EU EA WA NS	1438
	rs581000^1,2	A,C,F,O	67922859(+)	`TTTTTG/CAGCTT`	1	--	ng5¹ trp³		19	EA NA MN NS	1962
	rs606470^1,2	A,C,F	67926887(-)	`CCAACA/GTAAAA`	1	--	ng3¹		1	NS	174
--	rs828^1,2	C,F,H	67926166(+)	`AGGGGC/GTGAGT`	1	--	ut3¹		10	MN CSAM EA EU WA	994
	rs1511686^1,2	C,F,H	67921509(-)	`GCATGA/TATTCT`	1	--	ng5¹		10	NS MN EU EA WA	702
	rs1397946^1,2	C,F	67923486(+)	`TAGGCA/TGTGGC`	1	--	ut5¹		13	MN NS CSAM EA	1414
--	rs830^1,2	C,F	67926135(+)	`ACTGAT/CGCAAG`	1	--	ut3¹		5	MN CSAM EA	396
--	rs2620^1,2	C,F	67926117(+)	`CAAGCA/CGTTAC`	1	--	ut3¹		6	MN CSAM EA	580
--	rs829^1,2	C,F	67926106(+)	`TTGTAG/ATTACT`	1	--	ut3¹		6	MN CSAM EA	580
--	rs3783480^1,2	F	67926266(+)	`AAAAA-/GTAAGT`	1	--	ut3¹		1	NS	178

About this table

HapMap Linkage Disequilibrium images for GADD45A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 126335

UniProtKB/Swiss-Prot: GA45A_HUMAN, P24522

Induction of GADD45 in ataxia telangiectasia cells is abnormal

10/25 Novoseek disease relationships for GADD45A gene (see all 25 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ataxia telangiectasia	51.49	6	8500101 (1), 1990262 (1), 1423616 (1), 14609732 (1) (see all 6)
tumors	44.64	42	16827157 (5), 16211300 (2), 8631022 (2), 8834260 (2) (see all 29)
cancer	43.31	27	19003803 (3), 10327059 (2), 11063132 (1), 17436581 (1) (see all 14)
ovarian cancer	35.70	5	14506229 (3), 19305429 (2)
colon carcinoma	29.51	7	15772983 (3), 8631022 (1), 8950993 (1), 14642075 (1)
pancreatic cancer	28.74	13	16274047 (5), 17230496 (5), 19003803 (1), 12171884 (1)
breast carcinoma	28.19	4	15377844 (2), 15064713 (1), 10454607 (1)
xeroderma pigmentosum	27.11	1	12767947 (1)
colon cancer	24.64	2	8938795 (1), 15961301 (1)
leukemia	22.69	3	15031557 (1), 15744335 (1), 11251170 (1)

About this table

1 PharmGKB disease relationship for GADD45A gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872 12730115

About this table

Human Genome Epidemiology Navigator: GADD45A (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/324 PubMed articles for GADD45A gene (see all 324 ):

Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C. (PubMed id 1990262)^{1, 2, 3, 4} Papathanasiou M.A.... Fornace A.J. Jr. (1991)
Analysis of the mammalian gadd45 gene and its response to DNA damage. (PubMed id 8226988)^{2, 3, 4} Hollander M.C....Fornace A.J. (1993)
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. (PubMed id 7973727)^{1, 3, 4} Smith M.L.... Fornace A.J. Jr. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle. (PubMed id 12716909)^{3, 4} Chung H.K.... Shong M. (2003)
The central region of Gadd45 is required for its interaction with p21/WAF1. (PubMed id 10912791)^{1, 3} Zhao H....Zhan Q. (2000)
The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression. (PubMed id 10747892)^{1, 3} Jin S....Zhan Q. (2000)
B23 regulates GADD45a nuclear translocation and contributes to GADD45a-induced cell cycle G2-M arrest. (PubMed id 15644315)^{1, 3} Gao H....Zhan Q. (2005)
Mutation analysis of the Gadd45 gene at exon 4 in atypical fibroxanthoma. (PubMed id 19128509)^{1, 3} Sakamoto A....Tsuneyoshi M. (2009)
Characterization of human Gadd45, a p53-regulated protein. (PubMed id 7798274)^{1, 3} Carrier F....Gilmer T.M. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1647	HGNC: 4095	AceView: GADD45A	Ensembl:ENSG00000116717	euGenes: HUgn1647
ECgene: GADD45A	H-InvDB: GADD45A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for GADD45A	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/gadd45a/

Licensable Technologies for GADD45A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GADD45A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GADD45A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GADD45A		Antibodies for GADD45A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GADD45A		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GADD45A)
	Antibodies (GADD45A)
	Chimera RNAi (GADD45A)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (GADD45A)
	Antibodies (GADD45A)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for GADD45A

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GADD45A

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
GADD45A Gene at Home site.
Version 2.41.1
server5.xennexinc.com

GADD45A Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for GADD45A

Summaries
for GADD45A

Genomic Location
for GADD45A

Proteins
for GADD45A

Protein Domains/
Families
for GADD45A

Gene Function
for GADD45A

Pathways & Interactions
for GADD45A

Drugs & Compounds
for GADD45A

Transcripts
for GADD45A

Expression
for GADD45A

Orthologs
for GADD45A

Paralogs
for GADD45A

SNPs/Variants
for GADD45A

Disorders & Mutations
for GADD45A

Medical News
for GADD45A

Publications
for GADD45A

Search for GADD45A

Genome Databases showing GADD45A

Other Databases showing GADD45A

Specialized Databases showing GADD45A

Licensable Technologies
for GADD45A

Services
for GADD45A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GADD45A Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor GADD45A

Summariesfor GADD45A

Genomic Locationfor GADD45A

Proteinsfor GADD45A

Protein Domains/Familiesfor GADD45A

Gene Functionfor GADD45A

Pathways & Interactionsfor GADD45A

Drugs & Compoundsfor GADD45A

Transcriptsfor GADD45A

Expression for GADD45A

Orthologsfor GADD45A

Paralogsfor GADD45A

SNPs/Variantsfor GADD45A

Disorders & Mutationsfor GADD45A

Medical Newsfor GADD45A

Publicationsfor GADD45A

Search for GADD45A

Genome Databases showing GADD45A

Other Databases showing GADD45A

Specialized Databases showing GADD45A

Licensable Technologiesfor GADD45A

Servicesfor GADD45A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GADD45A

Summaries
for GADD45A

Genomic Location
for GADD45A

Proteins
for GADD45A

Protein Domains/
Families
for GADD45A

Gene Function
for GADD45A

Pathways & Interactions
for GADD45A

Drugs & Compounds
for GADD45A

Transcripts
for GADD45A

Expression
for GADD45A

Orthologs
for GADD45A

Paralogs
for GADD45A

SNPs/Variants
for GADD45A

Disorders & Mutations
for GADD45A

Medical News
for GADD45A

Publications
for GADD45A

Licensable Technologies
for GADD45A

Services
for GADD45A