Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GADD45A Gene

protein-coding   GIFtS: 66
GCID: GC01P068111

Growth Arrest And DNA-Damage-Inducible, Alpha


(Previous symbol: DDIT1)
  See GADD45A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Growth Arrest And DNA-Damage-Inducible, Alpha1 2     DNA Damage-Inducible Transcript-12
DDIT11 2 3 5     DNA-Damage-Inducible Transcript 12
GADD452 3 5     Growth Arrest And DNA Damage-Inducible Protein GADD45 Alpha2
DDIT-12 3     Growth Arrest And DNA-Damage-Inducible 45 Alpha2
DNA Damage-Inducible Transcript 1 Protein2 3     

External Ids:    HGNC: 40951   Entrez Gene: 16472   Ensembl: ENSG000001167177   OMIM: 1263355   UniProtKB: P245223   

Export aliases for GADD45A gene to outside databases

Previous GC identifers: GC01P067082 GC01P067508 GC01P067520 GC01P067862 GC01P067923 GC01P066261


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GADD45A Gene:
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest
conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental
stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced
transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced
transcript variants encoding distinct isoforms have been found for this gene.(provided by RefSeq, Dec 2010)

GeneCards Summary for GADD45A Gene:
GADD45A (growth arrest and DNA-damage-inducible, alpha) is a protein-coding gene. Diseases associated with GADD45A include oral cancer, and pancreatic cancer. GO annotations related to this gene include core promoter binding. An important paralog of this gene is GADD45B.

UniProtKB/Swiss-Prot: GA45A_HUMAN, P24522
Function: In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By
similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA
excision repair in vitro and inhibits entry of cells into S phase

Gene Wiki entry for GADD45A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the GADD45A gene promoter:
         C/EBPbeta   PPAR-gamma1   AP-1   ATF-2   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGADD45A promoter sequence
   Search Chromatin IP Primers for GADD45A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GADD45A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.2   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31.2

GADD45A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GADD45A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P068111:  view genomic region     (about GC identifiers)

Start:
68,150,744 bp from pter      End:
68,154,021 bp from pter
Size:
3,278 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GA45A_HUMAN, P24522 (See protein sequence)
Recommended Name: Growth arrest and DNA damage-inducible protein GADD45 alpha  
Size: 165 amino acids; 18336 Da
Subunit: Interacts with MAPK14 (By similarity). Predominantly monomeric but also forms dimers and other oligomers
as concentration increases. Interacts with GADD45GIP1. Interacts weakly with PCNA. Interacts with AURKA, likely
to compete with dimerization
1 PDB 3D structure from and Proteopedia for GADD45A:
2KG4 (3D)    
Secondary accessions: Q5TCA7 Q5TCA8
Alternative splicing: 2 isoforms:  P24522-1   P24522-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GADD45A: NX_P24522

Explore proteomics data for GADD45A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys29
  • Modification sites at PhosphoSitePlus

  • See GADD45A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001186670.1  NP_001186671.1  NP_001915.1  

    ENSEMBL proteins: 
     ENSP00000360025   ENSP00000360024  

    GADD45A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for GADD45A
    OriGene Protein Over-expression Lysate for GADD45A
    OriGene MassSpec for GADD45A
    OriGene Custom Protein Services for GADD45A
    GenScript Custom Purified and Recombinant Proteins Services for GADD45A
    Novus Biologicals GADD45A Proteins
    Novus Biologicals GADD45A Lysates
    Sino Biological Recombinant Protein for GADD45A
    Sino Biological Cell Lysate for GADD45A
    ProSpec Recombinant Protein for GADD45A
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GADD45A 

    GADD45A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GADD45A
    R&D Systems Antibodies for GADD45A (GADD45 alpha)
    Cell Signaling Technology (CST) Antibodies for GADD45A 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GADD45A
    Novus Biologicals GADD45A Antibodies
    Abcam antibodies for GADD45A
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for GADD45A
    LSBio Antibodies in human, mouse, rat for GADD45A

    GADD45A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GADD45A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GADD45A
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for GADD45A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR024824 GADD45
     IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45

    Graphical View of Domain Structure for InterPro Entry P24522

    ProtoNet protein and cluster: P24522

    1 Blocks protein domain: IPB004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45

    UniProtKB/Swiss-Prot: GA45A_HUMAN, P24522
    Similarity: Belongs to the GADD45 family


    Find genes that share domains with GADD45A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GA45A_HUMAN, P24522
    Function: In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By
    similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA
    excision repair in vitro and inhibits entry of cells into S phase
    Induction: By UV irradiation, X-rays, growth arrest and alkylating agents. The induction is mediated by some
    kinase(s) other than PKC

         Genatlas biochemistry entry for GADD45A:
    growth arrest and DNA-damage-inducible transcript alpha,involved in UV- and methyl methanisulfonate (MMS)-induced
    G2 arrest,p53-responsive stress protein activating MEKK4,interacting with the four core histones,mediating G2/M
    checkpoint,down-regulated by cyclin B1 and Cdc25C expression,inactivating (M phase promoting factor) MPF through
    interaction with CDC2 but not cyclin B1,putative downregulated c-Myc target gene,modifying DNA accessibility on
    damaged chromatin

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001047core promoter binding IEA--
    GO:0005515protein binding IPI12716909
         
    Find genes that share ontologies with GADD45A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GADD45A:
     Increased HPV18 LCR reporter a 

         13 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gadd45a):
     cardiovascular system  cellular  embryogenesis  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  nervous system 
     renal/urinary system  reproductive system  tumorigenesis 

    Find genes that share phenotypes with GADD45A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Gadd45atm1Ajf for GADD45A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GADD45A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GADD45A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GADD45A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GADD45A

    miRNA
    Products:
        
    miRTarBase miRNAs that target GADD45A:
    hsa-mir-615-3p (MIRT039859), hsa-mir-26b-5p (MIRT029880), hsa-mir-374a-5p (MIRT005574), hsa-mir-504-5p (MIRT016251)

    Block miRNA regulation of human, mouse, rat GADD45A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GADD45A (see all 10):
    hsa-miR-3163 hsa-miR-148b hsa-miR-374b hsa-miR-374a hsa-miR-500a hsa-miR-1248 hsa-miR-152 hsa-miR-362-5p
    SwitchGear 3'UTR luciferase reporter plasmidGADD45A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GADD45A
    Predesigned siRNA for gene silencing in human, mouse, rat GADD45A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GADD45A

    Clone
    Products:
         
    OriGene clones in human, mouse for GADD45A (see all 7)
    OriGene ORF clones in mouse, rat for GADD45A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): GADD45A (NM_001199741)
    Sino Biological Human cDNA Clone for GADD45A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GADD45A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GADD45A
    Addgene plasmids for GADD45A 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GADD45A
    Browse ESI BIO Cell Lines and PureStem Progenitors for GADD45A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GADD45A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GA45A_HUMAN, P24522: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA9827804

    Find genes that share ontologies with GADD45A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GADD45A About   (see all 23)  
    See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3p53 signaling pathway
    DNA damage response0.41
    p53 signaling pathway0.41
    4p53 Signaling
    p53 Signaling0.38
    p53 Pathway0.38
    5ATM Pathway
    ATM Pathway
    ATM Signaling Pathway0.00


    Find genes that share SuperPaths with GADD45A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GADD45A
        ATM Pathway
    BRCA1 Pathway
    DNA Repair Mechanisms
    p53 Signaling
    GADD45 Pathway

    1 Cell Signaling Technology (CST) Pathway for GADD45A
        DNA Damage

    1 GeneGo (Thomson Reuters) Pathway for GADD45A
        DNA damage ATM/ATR regulation of G1/S checkpoint

    Selected BioSystems Pathways for GADD45A (see all 16)
        MAPK signaling pathway
    Cell cycle
    DNA damage response
    Adipogenesis
    G1 to S cell cycle control

    1 Sino Biological Pathway for GADD45A
        p53 Pathway


    4 Kegg Pathways  (Kegg details for GADD45A):
        MAPK signaling pathway
    FoxO signaling pathway
    Cell cycle
    p53 signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GADD45A (see all 15): 
              Nephrotoxicity in human mouse rat
              HIV Host Response in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GADD45A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GADD45A (P245221, 2, 3 ENSP000003600254) via UniProtKB, MINT, STRING, and/or I2D (see all 135)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity TAS10747892
    GO:0000185activation of MAPKKK activity IDA9827804
    GO:0006281DNA repair TAS7973727
    GO:0006469negative regulation of protein kinase activity IEA--
    GO:0006915apoptotic process TAS10828065

    Find genes that share ontologies with GADD45A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GADD45A (GA45A)

    Selected Novoseek inferred chemical compound relationships for GADD45A gene (see all 41)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methylmethanesulfonate 76.7 15 8892753 (2), 1990262 (1), 9927186 (1), 10747892 (1) (see all 10)
    cd 437 55.2 14 10454607 (5), 9192771 (2)
    sb 203580 38.8 6 11544251 (1), 15064713 (1), 11525640 (1), 14609732 (1) (see all 5)
    cisplatin 35.3 15 9013707 (2), 8950993 (2), 8996528 (2), 19003803 (1) (see all 7)
    n-(4-hydroxyphenyl)retinamide 32.1 10 12175543 (6)
    camptothecin 28.5 4 10749144 (2)
    mnng 28.4 6 11516527 (3), 8649801 (2)
    troglitazone 27.8 14 15064713 (9), 12829999 (2)
    paclitaxel 20.5 4 19305429 (2), 11593420 (1)
    cycloheximide 20.5 1 7743505 (1)



    Find genes that share compounds with GADD45A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GADD45A gene (3 alternative transcripts): 
    NM_001199741.1  NM_001199742.1  NM_001924.3  

    Unigene Cluster for GADD45A:

    Growth arrest and DNA-damage-inducible, alpha
    Hs.80409  [show with all ESTs]
    Unigene Representative Sequence: NM_001924
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370986(uc001ddz.2 uc009wbb.2 uc009wbc.2 uc009wbd.2)
    ENST00000370985 ENST00000460575 ENST00000484245
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GADD45A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GADD45A (see all 10):
    hsa-miR-3163 hsa-miR-148b hsa-miR-374b hsa-miR-374a hsa-miR-500a hsa-miR-1248 hsa-miR-152 hsa-miR-362-5p
    SwitchGear 3'UTR luciferase reporter plasmidGADD45A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GADD45A
    Predesigned siRNA for gene silencing in human, mouse, rat GADD45A
    Clone
    Products:
         
    OriGene clones in human, mouse for GADD45A (see all 7)
    OriGene ORF clones in mouse, rat for GADD45A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): GADD45A (NM_001199741)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GADD45A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GADD45A
    Addgene plasmids for GADD45A 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GADD45A
    OriGene qSTAR qPCR primer pairs in human, mouse for GADD45A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GADD45A
      QuantiTect SYBR Green Assays in human, mouse, rat GADD45A
      QuantiFast Probe-based Assays in human, mouse, rat GADD45A

    Additional mRNA sequence: 

    AK314991.1 BC011757.2 DQ008445.1 EF581092.1 EF614238.1 M60974.1 

    7 DOTS entries:

    DT.114884  DT.114885  DT.95226036  DT.121441466  DT.95374637  DT.100743098  DT.95374636 

    Selected AceView cDNA sequences (see all 185):

    BI522580 CD368119 BX362575 BP336017 CB105352 BF726748 CA748690 BM982241 
    AA345605 AA535592 BQ575818 BX090426 BP374942 W93387 CB216147 BF726789 
    CR611787 CD365249 T86496 AW276454 AI357502 BE252585 CR608507 CR612467 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GADD45A    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b
    SP1:                          -                     
    SP2:                    -     -                     
    SP3:                                                


    ECgene alternative splicing isoforms for GADD45A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GADD45A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAGTTATT
    GADD45A Expression
    About this image


    GADD45A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)
             Secondary follicles
     
     Neurons
             Mature Rod Cells Outer Nuclear Layer
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer
    GADD45A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GADD45A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.80409
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GADD45A (see all 15): 
              Nephrotoxicity in human mouse rat
              HIV Host Response in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GADD45A
    OriGene qSTAR qPCR primer pairs in human, mouse for GADD45A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GADD45A
    QuantiTect SYBR Green Assays in human, mouse, rat GADD45A
    QuantiFast Probe-based Assays in human, mouse, rat GADD45A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GADD45A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for GADD45A gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gadd45a1 , 5 growth arrest and DNA-damage-inducible 45 alpha1, 5 90.51(n)1
    94.55(a)1
      6 (30.72 cM)5
    131971  NM_007836.11  NP_031862.11 
     670350965 
    chicken
    (Gallus gallus)
    Aves GADD45A1 growth arrest and DNA-damage-inducible, alpha 77.71(n)
    82.17(a)
      693255  NM_001044678.1  NP_001038143.1 
    lizard
    (Anolis carolinensis)
    Reptilia GADD45A6
    growth arrest and DNA-damage-inducible, alpha
    84(a)
    1 ↔ 1
    GL343328.1(164462-171169)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044046.12   -- 73.67(n)    BC044046.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.143742 Transcribed sequence with weak similarity to protein more 77.42(n)    CK029593.1 


    ENSEMBL Gene Tree for GADD45A (if available)
    TreeFam Gene Tree for GADD45A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GADD45A gene
    GADD45B2  GADD45G2  
    3 SIMAP similar genes for GADD45A using alignment to 2 protein entries:     GA45A_HUMAN (see all proteins):
    GADD45B    GRP17    GADD45G

    Find genes that share paralogs with GADD45A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GADD45A (see all 122)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1490278921,2
    --68148919(+) TTAGAA/TTTCAT 3 -- us2k10--------
    rs15116861,2
    C,F,H--68148921(-) GCATGA/TATTCT 3 -- us2k113Minor allele frequency- T:0.04NS MN EA NA WA 824
    rs1921316611,2
    --68149249(+) AAATGC/TTTCGG 3 -- us2k10--------
    rs1445889971,2
    --68149301(+) GACATC/TAAATG 3 -- us2k10--------
    rs1155171341,2
    F--68149321(+) AAGGCA/GTAGAT 3 -- us2k11Minor allele frequency- G:0.07WA 118
    rs1385357791,2
    --68149402(+) ATGGCC/TGACAA 3 -- us2k10--------
    rs1818940651,2
    --68149556(+) AGGTAC/TCTTTG 3 -- us2k10--------
    rs1849814521,2
    --68149616(+) AGCACC/TGTTTT 3 -- us2k10--------
    rs1159764501,2
    F--68149636(+) CATGTG/AGGAGC 3 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1897840321,2
    --68149707(+) AAACCA/GTAAAA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for GADD45A (68150744 - 68154021 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GADD45A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1276CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GADD45A
    DNA2.0 Custom Variant and Variant Library Synthesis for GADD45A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 126335    OMIM disorders: --

    4 diseases for GADD45A:    
    About MalaCards
    oral cancer    pancreatic cancer    breast cancer    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for GADD45A:
    Cancer

    Find genes that share disorders with GADD45A           About GenesLikeMe

    Selected Novoseek inferred disease relationships for GADD45A gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ataxia telangiectasia 53.2 6 8500101 (1), 1990262 (1), 1423616 (1), 14609732 (1) (see all 6)
    tumors 44 42 16827157 (5), 16211300 (2), 8631022 (2), 8834260 (2) (see all 29)
    cancer 43 28 19003803 (3), 10327059 (2), 11063132 (1), 17436581 (1) (see all 15)
    ovarian cancer 36.1 5 14506229 (3), 19305429 (2)
    colon carcinoma 28.2 7 15772983 (3), 8631022 (1), 8950993 (1), 14642075 (1)
    breast carcinoma 26.9 4 15377844 (2), 15064713 (1), 10454607 (1)
    pancreatic cancer 26.6 13 16274047 (5), 17230496 (5), 19003803 (1), 12171884 (1)
    xeroderma pigmentosum 25.9 1 12767947 (1)
    colon cancer 22.7 2 8938795 (1), 15961301 (1)
    leukemia 21.3 3 15031557 (1), 15744335 (1), 11251170 (1)

    Genetic Association Database (GAD): GADD45A
    Human Genome Epidemiology (HuGE) Navigator: GADD45A (11 documents)

    Export disorders for GADD45A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GADD45A gene, integrated from 10 sources (see all 389):
    (articles sorted by number of sources associating them with GADD45A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C. (PubMed id 1990262)1, 2, 3, 9 Papathanasiou M.A.... Fornace A.J. Jr. (Mol. Cell. Biol. 1991)
    2. Analysis of the mammalian gadd45 gene and its response to DNA damage. (PubMed id 8226988)1, 2, 3 Hollander M.C....Fornace A.J. Jr. (J. Biol. Chem. 1993)
    3. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. (PubMed id 7973727)1, 2, 9 Smith M.L.... Fornace A.J. Jr. (Science 1994)
    4. Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition? (PubMed id 20444249)1, 4 van Roon E.H....Morreau H. (BMC Cancer 2010)
    5. Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase. (PubMed id 20460379)1, 2 Sanchez R.... Blanco F.J. (J. Biol. Chem. 2010)
    6. Genetic contribution of GADD45A to susceptibility to sporadic and non-BRCA1/2 familial breast cancers: a systematic evaluation in Chinese populations. (PubMed id 19728081)1, 4 Yu K.D....Shao Z.M. (Breast Cancer Res. Treat. 2010)
    7. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
    8. Association of genetic polymorphisms in GADD45A, MDM2, and p14 ARF with the risk of chronic benzene poisoning in a Chinese occupational population. (PubMed id 19596022)1, 4 Sun P....Xia Z. (Toxicol. Appl. Pharmacol. 2009)
    9. A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. (PubMed id 19789190)1, 4 Young R.P....Gamble G.D. (Postgrad Med J 2009)
    10. Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. (PubMed id 19536092)1, 4 Kweekel D.M....Guchelaar H.J. (Br. J. Cancer 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1647 HGNC: 4095 AceView: GADD45A Ensembl:ENSG00000116717 euGenes: HUgn1647
    ECgene: GADD45A Kegg: 1647 H-InvDB: GADD45A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GADD45A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GADD45A Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/gadd45a/
    Wikipedia http://en.wikipedia.org/wiki/GADD45A

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GADD45A gene:
    Search GeneIP for patents involving GADD45A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of GADD45A
     
     EMD Millipore genomic analysis products

      
     Antibodies for GADD45A (GADD45 alpha)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for GADD45A  
     OriGene qPCR primer pairs and template standards for GADD45A   OriGene Protein Over-expression Lysate for GADD45A  
     OriGene MassSpec something-or-other for GADD45A   OriGene clones in human, mouse for GADD45A  
     OriGene qSTAR qPCR primer pairs in human, mouse for GADD45A   OriGene Purified Protein for GADD45A  
     OriGene ORF clones in mouse, rat for GADD45A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GADD45A   OriGene Custom Protein Services for GADD45A  

     
     
     Block miRNA regulation of human, mouse, rat GADD45A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GADD45A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GADD45A Predesigned siRNA for gene silencing in human, mouse, rat GADD45A
     QuantiFast Probe-based Assays in human, mouse, rat GADD45A QuantiTect SYBR Green Assays in human, mouse, rat GADD45A
     PCR Arrays including human, mouse, rat GADD45A Search Chromatin IP Primers for GADD45A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GADD45A  GeneGlobe Interaction Network for GADD45A
     Regulatory tfbs in GADD45A promoter
     GenScript Custom Purified and Recombinant Proteins Services for GADD45A GenScript cDNA clones with any tag delivered in your preferred vector for GADD45A
     GenScript Custom Assay Services for GADD45A GenScript Custom overexpressing Cell Line Services for GADD45A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for GADD45A 

     Search Tocris compounds for GADD45A (GA45A)
     Proteins for GADD45A
     Cell Lysates for GADD45A
     cDNA Clones for GADD45A
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GADD45A antibodies
     GADD45A proteins
     GADD45A lysates
     Antibodies for GADD45A
     See all of Abcam's Antibodies, Kits and Proteins for GADD45A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for GADD45A
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for GADD45A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GADD45A
     SwitchGear 3'UTR luciferase reporter plasmids for GADD45A
     SwitchGear Promoter luciferase reporter plasmids for GADD45A
     ThermoFisher Antibodies for GADD45A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GADD45A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GADD45A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GADD45A
     LSBio Antibodies in human, mouse, rat for GADD45A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for GADD45A
      Search eBioscience for proteins for GADD45A
      Search eBioscience for elisas for GADD45A
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GADD45A gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4