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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GADD45A Gene

protein-coding   GIFtS: 65
GCID: GC01P068111

growth arrest and DNA-damage-inducible, alpha


(Previous symbol: DDIT1)
 Explore 49 diseases affiliated with
GADD45A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GADD45A    

Aliases
for GADD45A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Growth Arrest And DNA-Damage-Inducible, Alpha1 2     DNA Damage-Inducible Transcript-12
DDIT11 2 3 5     DNA-Damage-Inducible Transcript 12
GADD451 2 3 5     Growth Arrest And DNA Damage-Inducible Protein GADD45 Alpha2
DDIT-12 3     Growth Arrest And DNA-Damage-Inducible 45 Alpha2
DNA Damage-Inducible Transcript 1 Protein2 3     

External Ids:    HGNC: 40951   Entrez Gene: 16472   Ensembl: ENSG000001167177   OMIM: 1263355   UniProtKB: P245223   

Export aliases for GADD45A gene to outside databases

Previous GC identifers: GC01P067082 GC01P067508 GC01P067520 GC01P067862 GC01P067923 GC01P066261


Summaries
for GADD45A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GADD45A:
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest
conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses
by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this
gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding
distinct isoforms have been found for this gene.(provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: GA45A_HUMAN, P24522
Function: In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By
similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA
excision repair in vitro and inhibits entry of cells into S phase

Gene Wiki entry for GADD45A


Genomic Views
for GADD45A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GADD45A gene promoter:
         C/EBPbeta   PPAR-gamma1   AP-1   ATF-2   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GADD45A promoter sequence
   Search SABiosciences Chromatin IP Primers for GADD45A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GADD45A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.2   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31.2

GADD45A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GADD45A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P068111:  view genomic region     (about GC identifiers)

Start:
 68,150,744 bp from pter      End:
 68,154,021 bp from pter
Size:
 3,278 bases      Orientation:
 plus strand

Proteins
for GADD45A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GA45A_HUMAN, P24522 (See protein sequence)
Recommended Name: Growth arrest and DNA damage-inducible protein GADD45 alpha  
Size: 165 amino acids; 18336 Da
Subunit: Interacts with MAPK14 (By similarity). Predominantly monomeric but also forms dimers and other oligomers as
concentration increases. Interacts with GADD45GIP1. Interacts weakly with PCNA. Interacts with AURKA, likely to
compete with dimerization
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for GADD45A:
2KG4 (3D)    
Secondary accessions: Q5TCA7 Q5TCA8
Alternative splicing: 2 isoforms:  P24522-1   P24522-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GADD45A: NX_P24522

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P24522

    • GADD45A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001186670.1  NP_001186671.1  NP_001915.1  

    ENSEMBL proteins: 
     ENSP00000360025   ENSP00000360024  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--


    GADD45A for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for GADD45A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GADD45A for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR024824 GADD45
     IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45

    Graphical View of Domain Structure for InterPro Entry P24522

    ProtoNet protein and cluster: P24522

    1 Blocks protein family: IPB004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45

    UniProtKB/Swiss-Prot: GA45A_HUMAN, P24522
    Similarity: Belongs to the GADD45 family


    Function
    for GADD45A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GA45A_HUMAN, P24522
    Function: In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By
    similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA
    excision repair in vitro and inhibits entry of cells into S phase
    Induction: By UV irradiation, X-rays, growth arrest and alkylating agents. The induction is mediated by some kinase(s)
    other than PKC

         Genatlas biochemistry entry for GADD45A:
    growth arrest and DNA-damage-inducible transcript alpha,involved in UV- and methyl methanisulfonate (MMS)-induced G2
    arrest,p53-responsive stress protein activating MEKK4,interacting with the four core histones,mediating G2/M
    checkpoint,down-regulated by cyclin B1 and Cdc25C expression,inactivating (M phase promoting factor) MPF through
    interaction with CDC2 but not cyclin B1,putative downregulated c-Myc target gene,modifying DNA accessibility on
    damaged chromatin

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    hsa-miR-3163 hsa-miR-148b hsa-miR-374b hsa-miR-374a hsa-miR-500a hsa-miR-1248 hsa-miR-152 hsa-miR-362-5p
    SwitchGear 3'UTR luciferase reporter plasmid: GADD45A 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--


    GADD45A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for GADD45A:
     Increased HPV18 LCR reporter a 

    Animal Models:
         Mouse knock-out Gadd45atm1Ajf for GADD45A
         13 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Gadd45a):
     cardiovascular system  cellular  embryogenesis  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  nervous system 
     renal/urinary system  reproductive system  tumorigenesis 

    GADD45A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GADD45A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell cycle
    		Cell cycle1.00
    		G1 to S cell cycle control0.38
    		Cell cycle0.57
    2DNA damage ATM/ATR regulation of G1/S checkpoint
    		DNA damage ATM/ATR regulation of G1/S checkpoint1.00
    		DNA damage_ATM/ATR regulation of G1/S checkpoint0.98
    3MAPK signaling pathway
    		MAPK signaling pathway1.00
    		MAPK signaling pathway0.50
    4p53 signaling pathway
    		p53 signaling pathway1.00
    		DNA damage response0.40
    5Integrated Pancreatic Cancer Pathway
    		Integrated Pancreatic Cancer Pathway1.00
    		Integrated Pancreatic Cancer Pathway0.99

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for GADD45A
        DNA damage ATM/ATR regulation of G1/S checkpoint

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GADD45A
        ATM Pathway
    BRCA1 Pathway
    DNA Repair Mechanisms
    p53 Signaling
    GADD45 Pathway

    1 Cell Signaling Technology (CST) Pathway for GADD45A
        DNA Damage

    1 GeneGo (Thomson Reuters) Pathway for GADD45A
        DNA damage ATM/ATR regulation of G1/S checkpoint

    5/15 BioSystems Pathways for GADD45A (see all 15) 
        Integrated Breast Cancer Pathway
    G1 to S cell cycle control
    Adipogenesis
    TP53 network
    DNA damage response


    3         Kegg Pathways  (Kegg details for GADD45A):
        MAPK signaling pathway
    Cell cycle
    p53 signaling pathway


    GADD45A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GADD45A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/124 Interacting proteins for GADD45A (P245221, 2, 3 ENSP000003600254) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein kinase activity TAS10747892
    GO:0000086G2/M transition of mitotic cell cycle ----
    GO:0006281DNA repair TAS7973727
    GO:0006469negative regulation of protein kinase activity IEA--
    GO:0006915apoptotic process TAS10828065


    GADD45A for ontologies           About GeneDecksing



    Drugs & Compounds
    for GADD45A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GADD45A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for GADD45A
    10/41 Novoseek chemical compound relationships for GADD45A gene (see all 41)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methylmethanesulfonate 76.7 15 8892753 (2), 1990262 (1), 9927186 (1), 10747892 (1) (see all 10)
    cd 437 55.2 14 10454607 (5), 9192771 (2)
    sb 203580 38.8 6 11544251 (1), 15064713 (1), 11525640 (1), 14609732 (1) (see all 5)
    cisplatin 35.3 15 9013707 (2), 8950993 (2), 8996528 (2), 19003803 (1) (see all 7)
    n-(4-hydroxyphenyl)retinamide 32.1 10 12175543 (6)
    camptothecin 28.5 4 10749144 (2)
    mnng 28.4 6 11516527 (3), 8649801 (2)
    troglitazone 27.8 14 15064713 (9), 12829999 (2)
    paclitaxel 20.5 4 19305429 (2), 11593420 (1)
    cycloheximide 20.5 1 7743505 (1)

    Search CenterWatch for drugs/clinical trials and news about GADD45A / GA45A 

    Transcripts
    for GADD45A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GADD45A gene (3 alternative transcripts): 
    NM_001199741.1  NM_001199742.1  NM_001924.3  

    Unigene Cluster for GADD45A:

    Growth arrest and DNA-damage-inducible, alpha
    Hs.80409  [show with all ESTs]
    Unigene Representative Sequence: NM_001924
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370986(uc001ddz.2 uc009wbb.2 uc009wbc.2 uc009wbd.2)
    ENST00000370985 ENST00000460575 ENST00000484245

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    Inhib. RNA
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    Additional cDNA sequence: 

    AK314991.1 BC011757.2 DQ008445.1 EF581092.1 EF614238.1 M60974.1 

    7 DOTS entries:

    DT.114884  DT.114885  DT.95226036  DT.121441466  DT.95374637  DT.100743098  DT.95374636 

    24/185 AceView cDNA sequences (see all 185):

    CR623510 AI129510 BX440645 BE252585 BF033052 CA430666 AU126574 BU629410 
    BP374942 BP336017 T86496 BM999842 BX645714 BQ923375 CR609553 BG152890 
    CD368119 BG473446 BQ575818 BF726748 CB105352 M60974 AA535592 BE501994 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GADD45A    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b
    SP1:                          -                     
    SP2:                    -     -                     
    SP3:                                                


    ECgene alternative splicing isoforms for GADD45A

    Expression
    for GADD45A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GADD45A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAAGTTATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GADD45A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    Gut TubeForegutForegut Endoderm CellsEndoderm
    KidneyGlomerulusKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Secondary follicles (Primary Cell)Ovary, Reproductive System

    See GADD45A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GADD45A

    SOURCE GeneReport for Unigene cluster: Hs.80409
        SABiosciences Expression via Pathway-Focused PCR Arrays including GADD45A (see all 15): 
              Nephrotoxicity in human mouse rat
              HIV Host Response in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat

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    In Situ
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    Orthologs
    for GADD45A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for GADD45A gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GADD45A1 growth arrest and DNA-damage-inducible, alpha 77.71(n)
    82.17(a)    		   693255  NM_001044678.1  NP_001038143.1 
    lizard
    (Anolis carolinensis)    		 Reptilia GADD45A6
    		 --
    		 84(a)
    		 1 ↔ 1
    		 GL343328.1(164734-170493)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC044046.12   -- 73.67(n)    BC044046.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.143742 Transcribed sequence with weak similarity to protein more 77.42(n)    CK029593.1 


    ENSEMBL Gene Tree for GADD45A (if available)
    TreeFam Gene Tree for GADD45A (if available) 

    Paralogs
    for GADD45A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GADD45A gene
    GADD45B2  GADD45G2  
    3 SIMAP similar genes for GADD45A using alignment to 2 protein entries:     GA45A_HUMAN (see all proteins):
    GADD45B    GRP17    GADD45G

    GADD45A for paralogs           About GeneDecksing



    Genomic Variants
    for GADD45A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/105 NCBI SNPs in GADD45A are shown (see all 105)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1490278921,2
    		--68148919(+) TTAGAA/TTTCAT 3 -- us2k10--------
    rs15116861,2
    		C,F,H,--68148921(-) GCATGA/TATTCT 3 -- us2k113Minor allele frequency- T:0.04NS MN EA NA WA 824
    rs1921316611,2
    		--68149249(+) AAATGC/TTTCGG 3 -- us2k10--------
    rs1445889971,2
    		--68149301(+) GACATC/TAAATG 3 -- us2k10--------
    rs1155171341,2
    		F,--68149321(+) AAGGCA/GTAGAT 3 -- us2k11Minor allele frequency- G:0.07WA 118
    rs1385357791,2
    		--68149402(+) ATGGCC/TGACAA 3 -- us2k10--------
    rs1818940651,2
    		--68149556(+) AGGTAC/TCTTTG 3 -- us2k10--------
    rs1849814521,2
    		--68149616(+) AGCACC/TGTTTT 3 -- us2k10--------
    rs1159764501,2
    		F,--68149636(+) CATGTG/AGGAGC 3 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1897840321,2
    		--68149707(+) AAACCA/GTAAAA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for GADD45A (68150744 - 68154021 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for GADD45A: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for GADD45A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GADD45A for disorders           About GeneDecksing

    OMIM gene information: 126335    OMIM disorders: --

    20/49 diseases for GADD45A (see all 49):    About MalaCards
    xeroderma pigmentosum    adenomatous polyposis coli    soft tissue sarcoma    ataxia telangiectasia
    burkitt's lymphoma    paranoid schizophrenia    pancreatic ductal adenocarcinoma    sporadic breast cancer
    chronic lymphocytic leukemia    epithelial ovarian cancer    lymphocytic leukemia    pituitary adenoma
    breast cancer    ovarian cancer    oral cancer    familial breast cancer
    lymphoblastic lymphoma    polyposis    colon carcinoma    ovarian carcinoma

    1 disease from the University of Copenhagen DISEASES database for GADD45A:
    Cancer

    10/25 Novoseek disease relationships for GADD45A gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ataxia telangiectasia 53.2 6 8500101 (1), 1990262 (1), 1423616 (1), 14609732 (1) (see all 6)
    tumors 44 42 16827157 (5), 16211300 (2), 8631022 (2), 8834260 (2) (see all 29)
    cancer 43 28 19003803 (3), 10327059 (2), 11063132 (1), 17436581 (1) (see all 15)
    ovarian cancer 36.1 5 14506229 (3), 19305429 (2)
    colon carcinoma 28.2 7 15772983 (3), 8631022 (1), 8950993 (1), 14642075 (1)
    breast carcinoma 26.9 4 15377844 (2), 15064713 (1), 10454607 (1)
    pancreatic cancer 26.6 13 16274047 (5), 17230496 (5), 19003803 (1), 12171884 (1)
    xeroderma pigmentosum 25.9 1 12767947 (1)
    colon cancer 22.7 2 8938795 (1), 15961301 (1)
    leukemia 21.3 3 15031557 (1), 15744335 (1), 11251170 (1)

    Human Genome Epidemiology (HuGE) Navigator: GADD45A (11 documents)

    Export disorders for GADD45A gene to outside databases

    Publications
    for GADD45A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GADD45A gene, integrated from 9 sources (see all 371):
    (articles sorted by number of sources associating them with GADD45A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C. (PubMed id 1990262)1, 2, 3, 9 Papathanasiou M.A.... Fornace A.J. Jr. (1991)
    2. Analysis of the mammalian gadd45 gene and its response to DNA damage. (PubMed id 8226988)1, 2, 3 Hollander M.C....Fornace A.J. Jr. (1993)
    3. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. (PubMed id 7973727)1, 2, 9 Smith M.L.... Fornace A.J. Jr. (1994)
    4. Solution structure of human growth arrest and DNA dam age 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase. (PubMed id 20460379)1, 2 SA!nchez R....Blanco F.J. (2010)
    5. Nucleolin links to arsenic-induced stabilization of GADD45alpha mRNA. (PubMed id 16421274)1, 2 Zhang Y.... Chen F. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle. (PubMed id 12716909)1, 2 Chung H.K.... Shong M. (2003)
    8. The central region of Gadd45 is required for its interaction with p21/WAF1. (PubMed id 10912791)1, 9 Zhao H....Zhan Q. (2000)
    9. The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression. (PubMed id 10747892)1, 9 Jin S....Zhan Q. (2000)
    10. B23 regulates GADD45a nuclear translocation and contributes to GADD45a-induced cell cycle G2-M arrest. (PubMed id 15644315)1, 9 Gao H....Zhan Q. (2005)

    External Searches for GADD45A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GADD45A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1647 HGNC: 4095 AceView: GADD45A Ensembl:ENSG00000116717 euGenes: HUgn1647
    ECgene: GADD45A Kegg: 1647 H-InvDB: GADD45A

    Other Databases showing GADD45A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GADD45A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GADD45A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GADD45A Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/gadd45a/
    Wikipedia http://en.wikipedia.org/wiki/GADD45A

    Intellectual Property
    for GADD45A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GADD45A gene:
    Search GeneIP for patents involving GADD45A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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