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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GABRR3 Gene

protein-coding   GIFtS: 51
GCID: GC03M097705          (predicted)

Gamma-Aminobutyric Acid (GABA) A Receptor, Rho 3

(Previous names: gamma-aminobutyric acid (GABA) receptor, rho 3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Gamma-Aminobutyric Acid (GABA) A Receptor, Rho 31 2     GABA(A) Receptor1
Gamma-Aminobutyric Acid (GABA) Receptor, Rho 31 2     Rho 31
GABA(A) Receptor Subunit Rho-32 3     Gamma-Aminobutyric Acid Receptor Subunit Rho-32
GABA(C) Receptor2 3     

External Ids:    HGNC: 179691   Entrez Gene: 2009592   Ensembl: ENSG000001831857   UniProtKB: A8MPY13   

Export aliases for GABRR3 gene to outside databases

Previous GC identifers: GC03M099188 GC03U900875 GC03M095075


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GABRR3 Gene:
The neurotransmitter gamma-aminobutyric acid (GABA) functions in the central nervous system to regulate synaptic
transmission of neurons. This gene encodes one of three related subunits, which combine as homo- or
hetero-pentamers to form GABA(C) receptors. In humans, some individuals contain a single-base polymorphism (dbSNP
rs832032) that is predicted to inactivate the gene product. (provided by RefSeq, Jan 2012)

GeneCards Summary for GABRR3 Gene: 
GABRR3 (gamma-aminobutyric acid (GABA) A receptor, rho 3) is a protein-coding gene. Diseases associated with GABRR3 include essential tremor, and tremor, and among its related super-pathways are Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell and Morphine addiction. GO annotations related to this gene include extracellular ligand-gated ion channel activity and protein domain specific binding.

UniProtKB/Swiss-Prot: GBRR3_HUMAN, A8MPY1
Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by
binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (By similarity)

summary for GABRR3 Gene:
GABAC receptors are Cys-loop ionotropic ligand-gated ion channels mediating the fast synaptic inhibitory
effects of GABA. Despite differing in physiology, biochemistry and pharmacology, GABAC receptors are viewed
as a subclass of GABAA receptors. GABAC receptors exist as both homo- and hetero-oligomeric pentamers of the
3 GABAC subunits which have so far been discovered; rho1, rho2, rho3. The resulting ion channel is not
blocked or modulated by GABAA receptor ligands, but is 10 times more sensitive to the effects of GABA and
selectively blocked by TPMPA. In addition, the GABAC receptor has a longer channel opening time and is
slower to desensitize. GABAC receptors are expressed in various brain regions and particularly high levels
are found in the retina.

Gene Wiki entry for GABRR3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_018914.2  NC_000003.11  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GABRR3 gene promoter:
         Oct-B1   Spz1   oct-B3   oct-B2   Pbx1a   POU2F2   GATA-1   FOXC1   POU2F1   POU2F1a   
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GABRR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q11.2   Ensembl cytogenetic band:  3q11.2   HGNC cytogenetic band: 3q12.2

GABRR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GABRR3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M097705:  view genomic region     (about GC identifiers)

Start:
97,705,517 bp from pter      End:
97,754,148 bp from pter
Size:
48,632 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GBRR3_HUMAN, A8MPY1 (See protein sequence)
Recommended Name: Gamma-aminobutyric acid receptor subunit rho-3 precursor  
Size: 467 amino acids; 54272 Da
Subunit: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and
rho. Forms a ternary complex with SQSTM1 and PRKCZ (By similarity)
Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (By
similarity). Cell membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: Q9UIV9

Explore the universe of human proteins at neXtProt for GABRR3: NX_A8MPY1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A8MPY1

  • GABRR3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_001099050.1  
    ENSEMBL proteins: 
     ENSP00000420790  
    Reactome Protein details: A8MPY1
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    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005886plasma membrane TAS--
    GO:0030054cell junction IEA--
    GO:0034707chloride channel complex IEA--
    GO:0045211postsynaptic membrane IEA--

    GABRR3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GABRA: Ligand-gated ion channels / GABA(A) receptors
    GABR: GABA receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: ρ3 
    GABAA receptors

    5 InterPro protein domains:
     IPR018000 Neurotransmitter_ion_chnl_CS
     IPR006028 GABAA_rcpt
     IPR006201 Neur_channel
     IPR006202 Neur_chan_lig-bd
     IPR006029 Neurotrans-gated_channel_TM

    Graphical View of Domain Structure for InterPro Entry A8MPY1

    ProtoNet protein and cluster: A8MPY1

    UniProtKB/Swiss-Prot: GBRR3_HUMAN, A8MPY1
    Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC
    1.A.9.5) subfamily. GABRR3 sub-subfamily


    GABRR3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBRR3_HUMAN, A8MPY1
    Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by
    binding to the GABA/benzodiazepine receptor and opening an integral chloride channel (By similarity)

         Genatlas biochemistry entry for GABRR3:
    gamma-aminobutyric acid (GABA) C receptor,ionotropic,rho 3,subunit part of a trimeric receptor

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004890GABA-A receptor activity NAS10542332
    GO:0005230extracellular ligand-gated ion channel activity IEA--
    GO:0005254chloride channel activity IEA--
         
    GABRR3 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GABRR3 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.67
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    2Circadian entrainment
    GABAergic synapse0.53
    Retrograde endocannabinoid signaling0.51
    Morphine addiction0.53
    3Activation of GABAB receptors
    GABA receptor activation0.72
    4SLC-mediated transmembrane transport
    Transmembrane transport of small molecules0.50
    5Ion channel transport
    Ion channel transport0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for GABRR3
        Sperm Motility

    5/8        Reactome Pathways for GABRR3 (see all 8)
        Ligand-gated ion channel transport
    Transmission across Chemical Synapses
    Ion channel transport
    Neuronal System
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell


    5         Kegg Pathways  (Kegg details for GABRR3):
        Neuroactive ligand-receptor interaction
    Retrograde endocannabinoid signaling
    GABAergic synapse
    Morphine addiction
    Nicotine addiction


    GABRR3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GABRR3

    2 Interacting proteins for GABRR3 (A8MPY13) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SQSTM1Q135013I2D: score=2 
    PRKCZQ055133I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007214gamma-aminobutyric acid signaling pathway NAS10542332
    GO:0007268synaptic transmission TAS--
    GO:0034220ion transmembrane transport TAS--
    GO:0055085transmembrane transport TAS--

    GABRR3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GABRR3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ZAPA sulfateAgonist at 'low affinity' GABAA receptor. More potent than GABA/muscimol[92138-10-8]
    THIP hydrochlorideGABAA agonist[64603-91-4]
    TPMPASelective GABAC antagonist[182485-36-5]

    2 HMDB Compounds for GABRR3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    Gamma-Aminobutyric acid3-Carboxypropylamine (see all 27)56-12-2--

    10/22 DrugBank Compounds for GABRR3 (see all 22)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Lorazepam(+/-)-Lorazepam (see all 3)846-49-1targetpotentiator20138190 18384456 11752090
    Adinazolam-- 37115-32-5targetpotentiator6320036 6148400
    Alprazolam-- 28981-97-7targetpotentiator18384456 11752090
    Bromazepam7-Bromo-5-(2-pyridyl)-3H-1,4-benzodiaxepin-2(1H)-one (see all 3)1812-30-2targetpotentiator18384456 11752090
    Chlordiazepoxide-- 58-25-3targetpotentiator18384456 11752090
    ClobazamAedon (see all 23)22316-47-8targetpotentiator18384456 11752090
    ClonazepamChlonazepam (see all 2)1622-61-3targetpotentiator18384456 11752090
    Clorazepate-- 23887-31-2targetpotentiator18384456 11752090
    Diazepam-- 439-14-5targetpotentiator18384456 11752090
    Estazolam-- 29975-16-4targetpotentiator639854 2889803

    10/13 IUPHAR Ligands for GABRR3 (ρ3) (see all 13)    About this table 
    LigandTypeActionAffinityPubmed IDs
    aza-THIP
    AntagonistAntagonist--
    TBPS
    Channel blockerNone--
    piperidine-4-sulphonic acid
    AntagonistAntagonist--
    muscimol
    AgonistPartial agonist--
    isoguvacine
    AgonistPartial agonist--
    cis-3-ACPBPA
    AntagonistAntagonist--
    trans-3-ACPBPA
    AntagonistAntagonist--
    THIP
    AntagonistAntagonist--
    5-Me-IAA
    AgonistFull agonist--
    (??)-cis-2-CAMP
    AgonistFull agonist--

    Search CenterWatch for drugs/clinical trials and news about GABRR3 / GBRR3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GABRR3 gene: 
    NM_001105580.2  

    Unigene Cluster for GABRR3:

    Gamma-aminobutyric acid (GABA) A receptor, rho 3
    Hs.534578  [show with all ESTs]
    Unigene Representative Sequence: CR749263
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000472788(uc021xbo.1) ENST00000470589(uc021xbp.1)
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    Additional mRNA sequence: 

    CR749263.1 NR_047685.1 

    1 DOTS entry:

    DT.40111423 

    10 AceView cDNA sequences:

    BM693967 BU729919 BM663963 BM690845 BM663724 BM704030 AV704203 CR749263 
    H37916 H38274 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GABRR3 expression in normal human tissues (normalized intensities)      GABRR3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATTGACAC
    GABRR3 Expression
    About this image


    GABRR3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
             Midbrain   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Ventral Horn   

    Genevestigator expression for GABRR3

    SOURCE GeneReport for Unigene cluster: Hs.534578
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABRR3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for GABRR3 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gabrr35 gamma-aminobutyric acid (GABA) receptor, rho 3   --   16 (34.83 cM) 59407382 


    ENSEMBL Gene Tree for GABRR3 (if available)
    TreeFam Gene Tree for GABRR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GABRR3 gene
    18/24 SIMAP similar genes for GABRR3 using alignment to 1 protein entry:     GBRR3_HUMAN(see all similar genes):
    GABRR1    GABRR2    GABRP    GABRQ    GABRB2    GABRD
    DKFZp781L0846    GLRA4    GLRA3    GABRB3    GLRA1    GABRB1
    GLRA2    GABRA2    GABRE    GABRA4    GLRB    GABRG2

    GABRR3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1078 SNPs in GABRR3 are shown (see all 1078)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1442205371,2
    --95075132(+) AAGGAA/GGGTTC 1 -- ds50010--------
    rs782552451,2
    F--95075156(+) ATAAAG/ACCCTT 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1149228291,2
    C,F--95075273(+) TTTCAA/GATTTT 1 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1839747741,2
    --95075323(+) ATCTAG/TGACTA 1 -- ds50010--------
    rs1511128391,2
    --95075353(+) TTTTGC/TTTTTA 1 -- ds50010--------
    rs1997818161,2
    C--95075412(+) CATATA/GCACCC 2 A V mis11Minor allele frequency- G:0.00EU 577
    rs3739226321,2
    C--95075471(+) GAATAG/TGTGTC 2 T syn10--------
    rs1411120611,2
    C--95075544(+) TTATCA/CGAGAT 2 R L mis10--------
    rs1890977951,2
    C--95075668(+) CATAGC/TTTGAA 2 T A mis10--------
    rs731408401,2
    --95075812(+) GATAGA/GCCAAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for GABRR3 (97705517 - 97754148 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for GABRR3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv877208CNV Loss21882294
    nsv470772CNV Loss18288195
    nsv509841CNV Loss20534489
    nsv877207CNV Gain21882294
    nsv520553CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    5 diseases for GABRR3:    About MalaCards
    essential tremor    tremor    schizoaffective disorder    bipolar disorder
    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for GABRR3:
    Schizoaffective disorder     Essential tremor

    GABRR3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GABRR3
    Human Genome Epidemiology (HuGE) Navigator: GABRR3 (5 documents)

    Export disorders for GABRR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GABRR3 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with GABRR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3. (PubMed id 10542332)1, 2, 3 Bailey M.E.S.... Darlison M.G. (1999)
    2. Strong genetic evidence for a selective influence of GABA(A) receptors on a component of the bipolar disorder phenotype. (PubMed id 19078961)1, 4 Craddock N....O'Donovan M.C. (2008)
    3. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    4. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (2006)
    5. Atypical behavioural effects of lorazepam: clues to t he design of novel therapies? (PubMed id 20138190)7 Giersch A....Vidailhet P. (2010)
    6. Gamma-aminobutyric acid (GABA) receptor rho (GABRR) p olymorphisms and risk for essential tremor. (PubMed id 20820800)1 GarcA-a-MartA-n E....JimAcnez-JimAcnez F.J. (2010)
    7. A genome-wide association study identifies a novel ma jor locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)4 Paterson A.D....Bull S.B. (2010)
    8. Benzodiazepines in epilepsy: pharmacology and pharmac okinetics. (PubMed id 18384456)7 Riss J....Collins S. (2008)
    9. Benzodiazepine metabolism: an analytical perspective. (PubMed id 18855614)7 Mandrioli R....Raggi M.A. (2008)
    10. GABA receptor rho subunit expression in the developing rat brain. (PubMed id 15617751)1 Alakuijala A....Pasternack M. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 200959 HGNC: 17969 AceView: GABRR3 Ensembl:ENSG00000183185 euGenes: HUgn200959
    ECgene: GABRR3 Kegg: 200959 H-InvDB: GABRR3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GABRR3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GABRR3 gene:
    Search GeneIP for patents involving GABRR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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