Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GABRR3 Gene

Aliases for GABRR3 Gene

  • Gamma-Aminobutyric Acid (GABA) A Receptor, Rho 3 (Gene/Pseudogene) 2 3
  • Gamma-Aminobutyric Acid (GABA) A Receptor, Rho 3 2
  • Gamma-Aminobutyric Acid (GABA) Receptor, Rho 3 2
  • GABA(A) Receptor Subunit Rho-3 4
  • GABA(A) Receptor 2
  • GABA(C) Receptor 4
  • Rho 3 2

External Ids for GABRR3 Gene

Previous GeneCards Identifiers for GABRR3 Gene

  • GC03M099188
  • GC03U900875
  • GC03M097705
  • GC03M095075

Summaries for GABRR3 Gene

Entrez Gene Summary for GABRR3 Gene

  • The neurotransmitter gamma-aminobutyric acid (GABA) functions in the central nervous system to regulate synaptic transmission of neurons. This gene encodes one of three related subunits, which combine as homo- or hetero-pentamers to form GABA(C) receptors. In humans, some individuals contain a single-base polymorphism (dbSNP rs832032) that is predicted to inactivate the gene product. [provided by RefSeq, Jan 2012]

GeneCards Summary for GABRR3 Gene

GABRR3 (Gamma-Aminobutyric Acid (GABA) A Receptor, Rho 3 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Circadian entrainment and GABA receptor activation. GO annotations related to this gene include chloride channel activity and GABA-A receptor activity. An important paralog of this gene is GABRR1.

UniProtKB/Swiss-Prot for GABRR3 Gene

  • GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Tocris Summary for GABRR3 Gene

  • GABAC receptors are Cys-loop ionotropic ligand-gated ion channels mediating the fast synaptic inhibitory effects of GABA. Despite differing in physiology, biochemistry and pharmacology, GABAC receptors are viewed as a subclass of GABAA receptors. GABAC receptors exist as both homo- and hetero-oligomeric pentamers of the 3 GABAC subunits which have so far been discovered; rho1, rho2, rho3. The resulting ion channel is not blocked or modulated by GABAA receptor ligands, but is 10 times more sensitive to the effects of GABA and selectively blocked by TPMPA. In addition, the GABAC receptor has a longer channel opening time and is slower to desensitize. GABAC receptors are expressed in various brain regions and particularly high levels are found in the retina.

Gene Wiki entry for GABRR3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GABRR3 Gene

Genomics for GABRR3 Gene

Regulatory Elements for GABRR3 Gene

Genomic Location for GABRR3 Gene

97,986,673 bp from pter
98,035,304 bp from pter
48,632 bases
Minus strand

Genomic View for GABRR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GABRR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GABRR3 Gene

Proteins for GABRR3 Gene

  • Protein details for GABRR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Gamma-aminobutyric acid receptor subunit rho-3
    Protein Accession:
    Secondary Accessions:
    • Q9UIV9

    Protein attributes for GABRR3 Gene

    467 amino acids
    Molecular mass:
    54272 Da
    Quaternary structure:
    • Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Forms a ternary complex with SQSTM1 and PRKCZ (By similarity).

neXtProt entry for GABRR3 Gene

Proteomics data for GABRR3 Gene at MOPED

Post-translational modifications for GABRR3 Gene

  • Glycosylation at Asn220
  • Modification sites at PhosphoSitePlus

Other Protein References for GABRR3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GABRR3 Gene

Domains for GABRR3 Gene

Gene Families for GABRR3 Gene

  • GABR :GABA receptors
  • GABRA :Ligand-gated ion channels / GABA(A) receptors

Suggested Antigen Peptide Sequences for GABRR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • A8MPY1
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR3 sub-subfamily.
genes like me logo Genes that share domains with GABRR3: view

Function for GABRR3 Gene

Molecular function for GABRR3 Gene

GENATLAS Biochemistry:
gamma-aminobutyric acid (GABA) C receptor,ionotropic,rho 3,subunit part of a trimeric receptor
UniProtKB/Swiss-Prot Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Gene Ontology (GO) - Molecular Function for GABRR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004890 GABA-A receptor activity NAS 10542332
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0005254 chloride channel activity IEA --
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with GABRR3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GABRR3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GABRR3 Gene

Localization for GABRR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GABRR3 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GABRR3 Gene COMPARTMENTS Subcellular localization image for GABRR3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GABRR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with GABRR3: view

Pathways for GABRR3 Gene

genes like me logo Genes that share pathways with GABRR3: view

Interacting Proteins for GABRR3 Gene

Selected Interacting proteins: A8MPY1-GBRR3_HUMAN for GABRR3 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for GABRR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport --
GO:0007214 gamma-aminobutyric acid signaling pathway NAS 10542332
GO:0007268 synaptic transmission TAS --
GO:0034220 ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with GABRR3: view

Compounds for GABRR3 Gene

(3) Tocris Compounds for GABRR3 Gene

Compound Action Cas Number
THIP hydrochloride GABAA agonist [85118-33-8]
TPMPA Selective GABAC antagonist [182485-36-5]
ZAPA sulfate Agonist at 'low affinity' GABAA receptor. More potent than GABA/muscimol [371962-01-5]

(7) ApexBio Compounds for GABRR3 Gene

Compound Action Cas Number
(R)-baclofen [69308-37-8]
Etomidate General anesthetic with GABA modulatory and GABA-mimetic actions [33125-97-2]
Flumazenil Benzodiazepine antagonist [78755-81-4]
Gabapentin GABA enhancer [60142-96-3]
Nefiracetam [77191-36-7]
Niflumic acid Ca2+-activated Cl- channel blocker [4394-00-7]
Rufinamide [106308-44-5]

(2) HMDB Compounds for GABRR3 Gene

Compound Synonyms Cas Number PubMed IDs
  • Cl2
Gamma-Aminobutyric acid
  • 3-Carboxypropylamine

(22) Drugbank Compounds for GABRR3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
37115-32-5 target potentiator
28981-97-7 target potentiator
  • 7-Bromo-5-(2-pyridyl)-3H-1,4-benzodiaxepin-2(1H)-one
1812-30-2 target potentiator
58-25-3 target potentiator
75696-02-5 target potentiator

(13) IUPHAR Ligand for GABRR3 Gene

Ligand Type Action Affinity Pubmed IDs
trans-3-ACPBPA Antagonist Antagonist
cis-3-ACPBPA Antagonist Antagonist
THIP Agonist Agonist
5-Me-IAA Agonist Full agonist
(??)-cis-2-CAMP Agonist Full agonist
isonipecotic acid Agonist Full agonist
picrotoxin Channel blocker None
TPMPA Antagonist Antagonist
isoguvacine Agonist Full agonist
muscimol Agonist Full agonist
piperidine-4-sulphonic acid Agonist Full agonist
TBPS Channel blocker None
aza-THIP Antagonist Antagonist
genes like me logo Genes that share compounds with GABRR3: view

Transcripts for GABRR3 Gene

mRNA/cDNA for GABRR3 Gene

(10) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GABRR3 Gene

Gamma-aminobutyric acid (GABA) A receptor, rho 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GABRR3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GABRR3 Gene

No ASD Table

Relevant External Links for GABRR3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GABRR3 Gene

mRNA expression in normal human tissues for GABRR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GABRR3 Gene

This gene is overexpressed in Testis (12.1), Liver (8.5), and Brain - Substantia nigra (4.6).

SOURCE GeneReport for Unigene cluster for GABRR3 Gene Hs.534578

genes like me logo Genes that share expressions with GABRR3: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for GABRR3 Gene

Orthologs for GABRR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GABRR3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GABRR3 35
  • 88.01 (n)
  • 84.58 (a)
  • 84 (a)
(Mus musculus)
Mammalia Gabrr3 35
  • 84.38 (n)
  • 84.67 (a)
Gabrr3 16
Gabrr3 36
  • 84 (a)
(Pan troglodytes)
Mammalia GABRR3 35
  • 99.5 (n)
  • 99.14 (a)
(Rattus norvegicus)
Mammalia Gabrr3 35
  • 85.75 (n)
  • 84.88 (a)
(Canis familiaris)
Mammalia GABRR3 36
  • 64 (a)
(Monodelphis domestica)
Mammalia GABRR3 36
  • 72 (a)
(Gallus gallus)
Aves GABRR3 35
  • 74.38 (n)
  • 75.16 (a)
  • 73 (a)
(Anolis carolinensis)
Reptilia GABRR3 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gabrr3 35
  • 72.11 (n)
  • 77.16 (a)
(Danio rerio)
Actinopterygii gabrr3a 35
  • 67.15 (n)
  • 73.19 (a)
gabrr3a 36
  • 64 (a)
gabrr3b 36
  • 67 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13992 35
Species with no ortholog for GABRR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GABRR3 Gene

Gene Tree for GABRR3 (if available)
Gene Tree for GABRR3 (if available)

Paralogs for GABRR3 Gene

Selected SIMAP similar genes for GABRR3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GABRR3: view

Variants for GABRR3 Gene

Sequence variations from dbSNP and Humsavar for GABRR3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs832021 -- 98,015,106(-) CAATC(C/T)ACTCA intron-variant
rs832022 -- 98,015,083(-) TTTTA(C/T)GTACA intron-variant
rs832023 -- 98,013,994(-) TTAAG(A/T)TTTGT intron-variant
rs832024 -- 98,013,229(-) CTCTG(A/G)GAACT intron-variant
rs832025 -- 98,010,969(-) gtgcc(C/T)gccac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GABRR3 Gene

Variant ID Type Subtype PubMed ID
nsv520553 CNV Gain 19592680
nsv877207 CNV Gain 21882294
nsv509841 CNV Loss 20534489
nsv877208 CNV Loss 21882294
nsv470772 CNV Loss 18288195

Relevant External Links for GABRR3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GABRR3 Gene

Disorders for GABRR3 Gene

(2) University of Copenhagen DISEASES for GABRR3 Gene

Relevant External Links for GABRR3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GABRR3: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for GABRR3 Gene

Publications for GABRR3 Gene

  1. Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3. (PMID: 10542332) Bailey M.E.S. … Darlison M.G. (Biochim. Biophys. Acta 1999) 2 3 4
  2. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4
  3. Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype. (PMID: 19078961) Craddock N. … O'Donovan M.C. (Mol. Psychiatry 2010) 3 48
  4. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 48
  5. Gamma-aminobutyric acid (GABA) receptor rho (GABRR) polymorphisms and risk for essential tremor. (PMID: 20820800) GarcA-a-MartA-n E. … JimAcnez-JimAcnez F.J. (J. Neurol. 2011) 3

Products for GABRR3 Gene

Sources for GABRR3 Gene

Back to Top