Aliases for GABRR3 Gene
- Gamma-Aminobutyric Acid Type A Receptor Rho3 Subunit (Gene/Pseudogene) 2 3
- Gamma-Aminobutyric Acid (GABA) A Receptor, Rho 3 (Gene/Pseudogene) 2 5
- Gamma-Aminobutyric Acid (GABA) A Receptor, Rho 3 2
- Gamma-Aminobutyric Acid (GABA) Receptor, Rho 3 2
- GABA(A) Receptor Subunit Rho-3 4
- GABA(A) Receptor 2
- GABA(C) Receptor 4
- Rho 3 2
External Ids for GABRR3 Gene
Previous GeneCards Identifiers for GABRR3 Gene
The neurotransmitter gamma-aminobutyric acid (GABA) functions in the central nervous system to regulate synaptic transmission of neurons. This gene encodes one of three related subunits, which combine as homo- or hetero-pentamers to form GABA(C) receptors. In humans, some individuals contain a single-base polymorphism (dbSNP rs832032) that is predicted to inactivate the gene product. [provided by RefSeq, Jan 2012]
GeneCards Summary for GABRR3 Gene
GABRR3 (Gamma-Aminobutyric Acid Type A Receptor Rho3 Subunit (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and GABA receptor activation. GO annotations related to this gene include protein domain specific binding and extracellular ligand-gated ion channel activity. An important paralog of this gene is GABRR1.
UniProtKB/Swiss-Prot for GABRR3 Gene
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
GABAA-rho receptors, previously known as GABAC receptors, are Cys-loop ionotropic ligand-gated ion channels mediating the fast synaptic inhibitory effects of GABA. Despite differing in pharmacology, physiology and biochemistry, they are viewed as a subclass of GABAA receptors.