Aliases for GABRR3 Gene
External Ids for GABRR3 Gene
Previous GeneCards Identifiers for GABRR3 Gene
The neurotransmitter gamma-aminobutyric acid (GABA) functions in the central nervous system to regulate synaptic transmission of neurons. This gene encodes one of three related subunits, which combine as homo- or hetero-pentamers to form GABA(C) receptors. In humans, some individuals contain a single-base polymorphism (dbSNP rs832032) that is predicted to inactivate the gene product. [provided by RefSeq, Jan 2012]
GeneCards Summary for GABRR3 Gene
GABRR3 (Gamma-Aminobutyric Acid (GABA) A Receptor, Rho 3 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Circadian entrainment and GABA receptor activation. GO annotations related to this gene include chloride channel activity and GABA-A receptor activity. An important paralog of this gene is GABRR1.
UniProtKB/Swiss-Prot for GABRR3 Gene
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
GABAC receptors are Cys-loop ionotropic ligand-gated ion channels mediating the fast synaptic inhibitory effects of GABA. Despite differing in physiology, biochemistry and pharmacology, GABAC receptors are viewed as a subclass of GABAA receptors. GABAC receptors exist as both homo- and hetero-oligomeric pentamers of the 3 GABAC subunits which have so far been discovered; rho1, rho2, rho3. The resulting ion channel is not blocked or modulated by GABAA receptor ligands, but is 10 times more sensitive to the effects of GABA and selectively blocked by TPMPA. In addition, the GABAC receptor has a longer channel opening time and is slower to desensitize. GABAC receptors are expressed in various brain regions and particularly high levels are found in the retina.