 |
 | Services
| |
 |
Aliases & Descriptions for GABRR2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| OTTHUMP00000040625 2 |
| | | Descriptions |
|---|
| GABA(A) receptor subunit rho-2 3 | | GABA-C receptor, rho-2 subunit 2 | | gamma-aminobutyric acid (GABA) receptor, rho 2 2 | | gamma-aminobutyric acid receptor, rho 2 1 |
|
| | Search outside databases for aliases for GABRR2 genePrevious GC identifers: GC06M089913 GC06M089962 |
Summaries for GABRR2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for GABRR2: GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. The protein encoded by this gene is a member of the rho subunit family and is a component of the GABA receptor complex. [provided by RefSeq] UniProtKB/Swiss-Prot: GBRR2_HUMAN, P28476Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmissionGene Wiki entry for GABRR2 |
Genomic Location for GABRR2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the GABRR2 gene 
Entrez Gene cytogenetic band: 6q14-q21|6q13-q16.3 Ensembl cytogenetic band: 6q15 HGNC cytogenetic band: 6q14-q21GABRR2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M090023:
(about GC identifiers)
Start:
|
90,023,958 bp from pter |
End:
|
90,081,737 bp from pter |
Size:
|
57,780 bases |
Orientation:
|
minus strand |
| Proteins for GABRR2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: GBRR2_HUMAN, P28476 (See
protein sequence)Recommended Name: Gamma-aminobutyric acid receptor subunit rho-2 precursor Size: 465 amino acids; 54151 Da
Subunit: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1 (By similarity)
Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Secondary accessions: A2BDE4 Q9H153Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002034.2
ENSEMBL proteins: ENSP00000386029 ENSP00000229606
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for GABRR2: Assays for GABRR2: | Protein
Domains/ Families for GABRR2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P28476
ProtoNet protein and cluster: P28476 4 Blocks protein families: IPB006028 Gamma-aminobutyric acid A (GABAA) receptor signature IPB006201 Neurotransmitter-gated ion-channel IPB008057 Gamma-aminobutyric-acid A (GABAA) receptor rho subunit signature IPB008059 Gamma-aminobutyric-acid A (GABAA) receptor rho 2 subunit signature
UniProtKB/Swiss-Prot: GBRR2_HUMAN, P28476Similarity: Belongs to the ligand-gated ionic channel (TC 1.A.9) family | Gene Function for GABRR2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002043
Applied Biosystems Silencer® siRNAs for GABRR2
Sigma-Aldrich siRNA and siRNA Panels for GABRR2  Sigma-Aldrich shRNA Panels and shRNA for GABRR2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002043                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002043                                  untagged cDNA clones in CMV expression vector (see all 2): NM_002043 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002043
UniProtKB/Swiss-Prot: GBRR2_HUMAN, P28476Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmissionGenatlas biochemistry entry for GABRR2:gamma-aminobutyric acid (GABA) C receptor,ionotropic,rho 2,preferentially expressed in retina,subunit part of a trimeric receptor,mediating inhibitory neurotransmission5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): About this table | Pathways & Interactions for GABRR2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for GABRR2 (Your Favorite Gene powered by Ingenuity) 
5/17 Interacting proteins for GABRR2 (ENSP000002296063) via UniProtKB, MINT, and/or STRING (see all 17
)About this table
5 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for GABRR2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for GABRR2 |
Compounds for GABRR2 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| THIP hydrochloride | GABAA agonist | [64603-91-4] | | Muscimol | Potent GABAA agonist | [2763-96-4] | | GABA | Endogenous agonist | [56-12-2] | | SKF 97541 | Extremely potent GABAB agonist | [127729-35-5] | | 1-EBIO | Activator of epithelial Kca channels | [10045-45-1] | About this table
|
Transcripts for GABRR2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002043
Sigma-Aldrich siRNA and siRNA Panels for GABRR2  Sigma-Aldrich shRNA Panels and shRNA for GABRR2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_002043 REFSEQ mRNAs for GABRR2 gene: NM_002043.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002043               OriGene GFP tagged cDNA clone in CMV expression vector: NM_002043                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002043                                  untagged cDNA clones in CMV expression vector (see all 2): NM_002043  4 AceView cDNA sequences:BX954216 M86868 NM_002043 BX490975
highest scoring ESTs for GABRR2:M86868 NM_002043 BQ362158 BX954216 BX490975 AA016195 BF673674 CR737449 DA659978 DA863180
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000402938
ENST00000229606
|
Expression for GABRR2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| GABRR2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for GABRR2
1 / 2 / 3 3 probe-sets matching GABRR2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGGTAAAGGA
Expression variation in blood from EXPOLDB for GABRR2 |
Orthologs for GABRR2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GABRR2 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for GABRR2
ENSEMBL Gene Tree for GABRR2 | Paralogs for GABRR2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for GABRR2 gene
- GABRR12
|
SNPs/Variants for GABRR2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for GABRR2 (up to first 250kb)
|
Disorders & Mutations for GABRR2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 137162
Human Genome Epidemiology Navigator: GABRR2 (4 documents)
|
Medical News for GABRR2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for GABRR2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/14 PubMed articles for GABRR2 gene (see all 14
):- Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4. (PubMed id 1315307)2, 3, 4 Cutting G.R....Uhl G.R. (1992)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)3, 4 Mungall A.J.... Beck S. (2003)
- Strong genetic evidence for a selective influence of GABA(A) receptors on a component of the bipolar disorder phenotype. (PubMed id 19078961)3 Craddock N....O'Donovan M.C. (2008)
- Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)3 GratacA^s M....Carracedo A. (2008)
- Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study. (PubMed id 17913586)3 Cavalleri G.L....Goldstein D.B. (2007)
- ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2. (PubMed id 12431995)3 Croci C....Enz R. (2003)
- Molecular and physiological evidence for functional gamma-aminobutyric acid (GABA)-C receptors in growth hormone-secreting cells. (PubMed id 12660236)3 Gamel-Didelon K....Mayerhofer A. (2003)
- Phosphorylation of the recombinant rho1 GABA receptor. (PubMed id 12175859)3 Sedelnikova A. and Weiss D.S. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for GABRR2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing GABRR2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing GABRR2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GABRR2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for GABRR2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for GABRR2:

|
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|