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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GABRR2 Gene

protein-coding GIFtS: 61
GCID: GC06M089967

gamma-aminobutyric acid (GABA) A receptor, rho 2

(Previous names: gamma-aminobutyric acid (GABA) receptor, rho 2 )

Explore 12 diseases affiliated with
GABRR2 via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Gamma-Aminobutyric Acid (GABA) A Receptor, Rho 2¹ ²		GABA(A) Receptor, Rho 2²
Gamma-Aminobutyric Acid (GABA) Receptor, Rho 2¹ ²		GABA-C Receptor, Rho-2 Subunit²
GABA(A) Receptor Subunit Rho-2² ³		Gamma-Aminobutyric Acid Receptor Subunit Rho-2²
GABA(C) Receptor² ³

External Ids:	HGNC: 4091¹	Entrez Gene: 2570²	Ensembl: ENSG00000111886⁷	OMIM: 137162⁵	UniProtKB: P28476³

Export aliases for GABRR2 gene to outside databases

Previous GC identifers: GC06M089913 GC06M089962 GC06M090023 GC06M087184

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GABRR2:

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are

ligand-gated chloride channels. The protein encoded by this gene is a member of the rho subunit family and is a

component of the GABA receptor complex. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GBRR2_HUMAN, P28476

Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding

to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in

retinal neurotransmission

summary for GABRR2:

GABAC receptors are Cys-loop ionotropic ligand-gated ion channels mediating the fast synaptic inhibitory

effects of GABA. Despite differing in physiology, biochemistry and pharmacology, GABAC receptors are viewed

as a subclass of GABAA receptors. GABAC receptors exist as both homo- and hetero-oligomeric pentamers of the

3 GABAC subunits which have so far been discovered; rho1, rho2, rho3. The resulting ion channel is not

blocked or modulated by GABAA receptor ligands, but is 10 times more sensitive to the effects of GABA and

selectively blocked by TPMPA. In addition, the GABAC receptor has a longer channel opening time and is

slower to desensitize. GABAC receptors are expressed in various brain regions and particularly high levels

are found in the retina.

Gene Wiki entry for GABRR2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007299.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GABRR2 gene promoter:
HOXA9B HOXA9 AML1a POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) Cdc5 POU3F2 Meis-1b FOXC1 Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GABRR2 promoter sequence

Search SABiosciences Chromatin IP Primers for GABRR2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GABRR2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q15 Ensembl cytogenetic band: 6q15 HGNC cytogenetic band: 6q15

GABRR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GABRR2 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M089967: view genomic region (about GC identifiers)

Start:	89,967,239 bp from pter	End:	90,025,018 bp from pter
Size:	57,780 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GBRR2_HUMAN, P28476 (See protein sequence)

Recommended Name: Gamma-aminobutyric acid receptor subunit rho-2 precursor

Size: 465 amino acids; 54151 Da

Subunit: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

Interacts with SQSTM1 (By similarity)

Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane;

Multi-pass membrane protein

Secondary accessions: A2BDE4 Q9H153

Alternative initiation: 2 isoforms: P28476-1 P28476-2 (Isoform 2 could be translated from an upstream initiator ATG located in frame within the first coding exon. The probability of a signal peptide within this isoform is very low. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GABRR2: NX_P28476

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P28476

GABRR2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002034.3

ENSEMBL proteins:

ENSP00000386029

Reactome Protein details: P28476
Human Recombinant Protein Products for GABRR2:

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Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	1315307
GO:0030054	cell junction	IEA	--
GO:0034707	chloride channel complex	IEA	--
GO:0045211	postsynaptic membrane	IEA	--

GABRR2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GABRR2 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR008057 GABAAa_rho_rcpt

IPR018000 Neurotransmitter_ion_chnl_CS

IPR006028 GABAA_rcpt

IPR006201 Neur_channel

IPR008059 GABAAa_rho2_rcpt

Graphical View of Domain Structure for InterPro Entry P28476

ProtoNet protein and cluster: P28476

4 Blocks protein families:

IPB006028 Gamma-aminobutyric acid A (GABAA) receptor signature

IPB006201 Neurotransmitter-gated ion-channel

IPB008057 Gamma-aminobutyric-acid A (GABAA) receptor rho subunit signature

IPB008059 Gamma-aminobutyric-acid A (GABAA) receptor rho 2 subunit signature

UniProtKB/Swiss-Prot: GBRR2_HUMAN, P28476

Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5)

subfamily. GABRR2 sub-subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: GBRR2_HUMAN, P28476

Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding

to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in

retinal neurotransmission

Genatlas biochemistry entry for GABRR2:

gamma-aminobutyric acid (GABA) C receptor,ionotropic,rho 2,preferentially expressed in retina,subunit part of a

trimeric receptor,mediating inhibitory neurotransmission

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004890	GABA-A receptor activity	IEA	--
GO:0005230	extracellular ligand-gated ion channel activity	IEA	--
GO:0005254	chloride channel activity	IEA	--
GO:0019904	protein domain specific binding	IEA	--

GABRR2 for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABRR2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Transmission across Chemical Synapses

	Transmission across Chemical Synapses	1.00			Neuronal System	0.67
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	0.72

Ion channel transport

Ion channel transport

1.00

GABA A (rho) receptor activation

GABA A (rho) receptor activation

1.00

Activation of GABAB receptors

GABA receptor activation

0.72

SLC-mediated transmembrane transport

Transmembrane transport of small molecules

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for GABRR2

Sperm Motility

5/8 Reactome Pathways for GABRR2 (see all 8)

	Ligand-gated ion channel transport
	Transmission across Chemical Synapses
	Ion channel transport
	Neuronal System
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell

1 Kegg Pathway (Kegg details for GABRR2):

Neuroactive ligand-receptor interaction

GABRR2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GABRR2

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/6 Interacting proteins for GABRR2 (P28476³ ENSP00000386029⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SQSTM1	Q13501³, ENSP00000374455⁴	I2D: score=2 STRING: ENSP00000374455
GABRR1	P24046³, ENSP00000412673⁴	I2D: score=1 STRING: ENSP00000412673
MAP1B	P46821³, ENSP00000296755⁴	I2D: score=1 STRING: ENSP00000296755
PRKCA	P17252³, ENSP00000284384⁴	I2D: score=1 STRING: ENSP00000284384
CSNK2A1	P68400³, ENSP00000217244⁴	I2D: score=1 STRING: ENSP00000217244

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	TAS	1315307
GO:0007165	signal transduction	TAS	1315307
GO:0007214	gamma-aminobutyric acid signaling pathway	IEA	--
GO:0007268	synaptic transmission	TAS	--
GO:0007601	visual perception	IEA	--

GABRR2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for GABRR2 available from Tocris Bioscience About this table

Compound	Action	CAS #
Muscimol	Potent GABAA agonist	[2763-96-4]
SKF 97541	Extremely potent GABAB agonist	[127729-35-5]
THIP hydrochloride	GABAA agonist	[64603-91-4]
GABA	Endogenous agonist	[56-12-2]
1-EBIO	Activator of epithelial Kca channels	[10045-45-1]

2 HMDB Compounds for GABRR2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Chlorine	Cl2 (see all 13)	16887-00-6	--
Gamma-Aminobutyric acid	3-Carboxypropylamine (see all 27)	56-12-2	--

10/22 DrugBank Compounds for GABRR2 (see all 22) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Lorazepam	(+/-)-Lorazepam (see all 3)	846-49-1	target	potentiator	20138190 18384456 11752090
Adinazolam	--	37115-32-5	target	potentiator	6320036 6148400
Chlordiazepoxide	--	58-25-3	target	potentiator	18384456 11752090
Clobazam	--	22316-47-8	target	potentiator	18384456 11752090
Clonazepam	Chlonazepam (see all 2)	1622-61-3	target	potentiator	18384456 11752090
Clorazepate	--	23887-31-2	target	potentiator	18384456 11752090
Diazepam	--	439-14-5	target	potentiator	18384456 11752090
Estazolam	--	29975-16-4	target	potentiator	639854 2889803
Flurazepam	--	17617-23-1	target	potentiator	18384456 11752090
Halazepam	--	23092-17-3	target	potentiator	2867566 6738302

Search CenterWatch for drugs/clinical trials and news about GABRR2 / GBRR2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GABRR2 gene:

NM_002043.3

Unigene Cluster for GABRR2:

Gamma-aminobutyric acid (GABA) A receptor, rho 2

Hs.719891 [show with all ESTs]

Unigene Representative Sequence: NM_002043

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000402938(uc011dzx.1 uc003pnb.2)

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Additional cDNA sequence:

AK293751.1 BC130352.1 BC130354.1 M86868.1

2 DOTS entries:

DT.40119877 DT.100650939

4 AceView cDNA sequences:

NM_002043 BX954216 M86868 BX490975

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GABRR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCATTGACAA

About this image

GABRR2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Rod Bipolar Cells

Bipolar, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

See GABRR2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GABRR2

SOURCE GeneReport for Unigene cluster: Hs.719891

SABiosciences Expression via Pathway-Focused PCR Arrays including GABRR2:

Neurotransmitter Receptors in human mouse rat

GABA & Glutamate in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for GABRR2 gene from 3/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	GABRR2¹	gamma-aminobutyric acid (GABA) receptor, rho 2	80.89(n) 86.85(a)		421815 XM_419839.3 XP_419839.3
lizard (Anolis carolinensis)	Reptilia	GABRR2⁶	--	81(a)	1 ↔ 1	1(175025716-175064710)
zebrafish (Danio rerio)	Actinopterygii	Dr.15556²	Transcribed sequence with moderate similarity to protein more	81.53(n)		BM316919.1

ENSEMBL Gene Tree for GABRR2 (if available)
TreeFam Gene Tree for GABRR2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GABRR2 gene

GLRA2² GABRR1² GLRB² GLRA1² GABRB1² GABRD² GLRA4² GABRP²

GABRB2² GABRQ² GABRB3² GLRA3²

18/24 SIMAP similar genes for GABRR2 using alignment to 1 protein entry: GBRR2_HUMAN(see all similar genes):

GABRR1 GABRR3 GABRP GABRQ GABRD GLRA4

GABRA4 DKFZp781L0846 GABRB3 GABRB1 GLRA1 GLRA2

GLRA3 GABRB2 GABRG2 GABRA6 GABRA5 GABRA2

GABRR2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75568960^1,2	C,F	--	89966431(+)	`CAGCTA/GTAAAT`	1	--	ds500¹		1		WA	118
rs186667081^1,2		--	89966444(+)	`ATGACC/TGACCC`	1	--	ds500¹		0	--	--	--	--
rs282130^1,2	C,F,H	--	89966655(-)	`CAGACC/ACATTC`	1	--	ds500¹		7		NS EA WA CSA	532
rs4707534^1,2	C,H	--	89966733(+)	`ACTTAG/TAGAAG`	1	--	ds500¹		4		NS EA	410
rs149713369^1,2		--	89966744(+)	`ATCTCC/TAAGGA`	1	--	ds500¹		0	--	--	--	--
rs144566309^1,2		--	89966774(+)	`TCTACC/TGTACC`	1	--	ds500¹		0	--	--	--	--
rs112141392^1,2	C,F	--	89966775(+)	`CTACCG/ATACCT`	1	--	ds500¹		1		NA	120
rs113424515^1,2	C	--	89966779(+)	`CGTACC/TTGGCA`	1	--	ds500¹		0	--	--	--	--
rs192335428^1,2		--	89966787(+)	`GCACAG/TAGTGG`	1	--	ds500¹		0	--	--	--	--
rs184670304^1,2		--	89966884(+)	`CCACAG/TGCCAA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GABRR2 (89967239 - 90025018 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for GABRR2
1 CNV: 52021
Human Gene Mutation Database (HGMD): GABRR2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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GABRR2 for disorders           About GeneDecksing

OMIM gene information: 137162    OMIM disorders: --

12 diseases for GABRR2:    About MalaCards

essential tremor anorexia nervosa schizoaffective disorder tremor

alcohol dependence bipolar disorder epilepsy syndrome alcoholism

seizures retinitis schizophrenia neuronitis

Human Genome Epidemiology (HuGE) Navigator: GABRR2 (11 documents)

Export disorders for GABRR2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GABRR2 gene, integrated from 9 sources (see all 38):
(articles sorted by number of sources associating them with GABRR2)

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Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4. (PubMed id 1315307)^{1, 2, 3} Cutting G.R....Uhl G.R. (1992)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
A meta-analysis of genome-wide data from five Europea n isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creat inine level. (PubMed id 20222955)^{1, 9} Pattaro C....Pramstaller P.P. (2010)
Potential role of GABAA receptor subunit; GABRA6, GAB RB2 and GABRR2 gene polymorphisms in epilepsy susceptibility and pharmacotherap y in North Indian population. (PubMed id 21420396)¹ Kumari R....Mittal B. (2011)
Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder. (PubMed id 20583128)¹ Green E.K....Craddock N. (2010)
Atypical behavioural effects of lorazepam: clues to t he design of novel therapies? (PubMed id 20138190)⁷ Giersch A....Vidailhet P. (2010)
Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)¹ Pinheiro A.P....Woodside D.B. (2010)
Gamma-aminobutyric acid (GABA) receptor rho (GABRR) p olymorphisms and risk for essential tremor. (PubMed id 20820800)¹ GarcA-a-MartA-n E....JimAcnez-JimAcnez F.J. (2010)
A genome-wide meta-analysis identifies novel loci ass ociated with schizophrenia and bipolar disorder. (PubMed id 20889312)¹ Wang K.S....Aragam N. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2570	HGNC: 4091	AceView: GABRR2	Ensembl:ENSG00000111886	euGenes: HUgn2570
ECgene: GABRR2	Kegg: 2570	H-InvDB: GABRR2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GABRR2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GABRR2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GABRR2 gene:
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GABRR2 Gene

gamma-aminobutyric acid (GABA) A receptor, rho 2

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GABRR2 Gene

gamma-aminobutyric acid (GABA) A receptor, rho 2

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