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GABRQ Gene

protein-coding   GIFtS: 62
GCID: GC0XP151806

Gamma-Aminobutyric Acid (GABA) A Receptor, Theta

(Previous names: gamma-aminobutyric acid (GABA) receptor, theta)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Gamma-Aminobutyric Acid (GABA) A Receptor, Theta1 2     theta1
GABA(A) Receptor Subunit Theta2 3     THETA2
GABA(A) Receptor1     Gamma-Aminobutyric Acid Receptor Subunit Theta2
Gamma-Aminobutyric Acid (GABA) Receptor, Theta1     

External Ids:    HGNC: 144541   Entrez Gene: 558792   Ensembl: ENSG000001474027   OMIM: 3003495   UniProtKB: Q9UN883   

Export aliases for GABRQ gene to outside databases

Previous GC identifers: GC0XP146146 GC0XP148463 GC0XP149554 GC0XP150424 GC0XP151477 GC0XP140659


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GABRQ Gene:
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest
inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A
receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and
epsilon subunits of the GABA A receptor. This gene location is also the candidate region of two different
neurologic diseases: early-onset parkinsonism (Waisman syndrome) and X-linked mental retardation (MRX3).
(provided by RefSeq, Nov 2009)

GeneCards Summary for GABRQ Gene:
GABRQ (gamma-aminobutyric acid (GABA) A receptor, theta) is a protein-coding gene. GO annotations related to this gene include transmembrane signaling receptor activity and extracellular ligand-gated ion channel activity. An important paralog of this gene is GLRA2.

UniProtKB/Swiss-Prot: GBRT_HUMAN, Q9UN88
Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by
binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

summary for GABRQ Gene:
GABAA receptors are members of the cys-loop family of ligand-gated ion channels, responsible for mediating
the inhibitory effects of GABA alongside GABAB and GABAC receptors. They are pentameric proteins, consisting
of 5 subunits belonging to different families (alpha1-6, beta1-3, gamma1-3, delta, pi, epsilon, rho, theta).
The most abundant GABAA receptor in the mammalian brain consist of two copies each of alpha1 and beta2 with
a single gamma2 subunits. GABAA receptors contain an integral chloride channel, and have modulatory sites
for benzodiazepines, barbiturates, neurosteroids and ethanol.

Gene Wiki entry for GABRQ Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011681.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the GABRQ gene promoter:
         C/EBPbeta   p53   NCX/Ncx   ATF-2   CUTL1   GATA-1   E47   AREB6   CRE-BP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGABRQ promoter sequence
   Search Chromatin IP Primers for GABRQ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GABRQ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

GABRQ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GABRQ gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP151806:  view genomic region     (about GC identifiers)

Start:
151,806,637 bp from pter      End:
151,825,999 bp from pter
Size:
19,363 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GBRT_HUMAN, Q9UN88 (See protein sequence)
Recommended Name: Gamma-aminobutyric acid receptor subunit theta precursor  
Size: 632 amino acids; 72022 Da
Subunit: Generally pentameric. This subunit coassembles with alpha-2, beta-1 and gamma-1
Secondary accessions: A6NFN1 Q32MB4 Q9NZK8

Explore the universe of human proteins at neXtProt for GABRQ: NX_Q9UN88

Explore proteomics data for GABRQ at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn127
  • Modification sites at PhosphoSitePlus

  • See GABRQ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061028.3  
    ENSEMBL proteins: 
     ENSP00000359329  

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    antibodies-online peptides for GABRQ

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    antibodies-online antibodies for GABRQ (24 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GABRA: Ligand-gated ion channels / GABA(A) receptors
    GABR: GABA receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: theta
    GABAA receptors

    Selected InterPro protein domains (see all 6):
     IPR008101 GABAAt_rcpt
     IPR018000 Neurotransmitter_ion_chnl_CS
     IPR006028 GABAA_rcpt
     IPR006201 Neur_channel
     IPR006202 Neur_chan_lig-bd

    Graphical View of Domain Structure for InterPro Entry Q9UN88

    ProtoNet protein and cluster: Q9UN88

    3 Blocks protein domains:
    IPB006028 Gamma-aminobutyric acid A (GABAA) receptor signature
    IPB006201 Neurotransmitter-gated ion-channel
    IPB008101 Gamma-aminobutyric-acid A receptor theta subunit signature


    UniProtKB/Swiss-Prot: GBRT_HUMAN, Q9UN88
    Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC
    1.A.9.5) subfamily. GABRQ sub-subfamily


    Find genes that share domains with GABRQ           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBRT_HUMAN, Q9UN88
    Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by
    binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS10449790
    GO:0004890GABA-A receptor activity IEA--
    GO:0005230extracellular ligand-gated ion channel activity IEA--
    GO:0005254chloride channel activity IEA--
    GO:0005326neurotransmitter transporter activity TAS10449790
         
    Find genes that share ontologies with GABRQ           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for GABRQ:
     Cell cycle / mitosis defect  G0/1 arrest  Increased G1 DNA content  Metaphase cells 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Gabrq):
     nervous system 

    Find genes that share phenotypes with GABRQ           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for GABRQ

    miRNA
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    miRTarBase miRNAs that target GABRQ:
    hsa-mir-335-5p (MIRT017369)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GBRT_HUMAN, Q9UN88: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell
    membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    lysosome1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS10449790
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0030054cell junction IEA--
    GO:0034707chloride channel complex IEA--

    Find genes that share ontologies with GABRQ           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GABRQ About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Circadian entrainment
    GABAergic synapse0.53
    Retrograde endocannabinoid signaling0.51
    Morphine addiction0.53
    2Akt Signaling
    Akt Signaling0.60
    3Apoptosis Pathway
    Akt Pathway0.39
    4Sweet Taste Signaling
    Sperm Motility0.37
    5Peptide ligand-binding receptors
    Neuroactive ligand-receptor interaction0.36


    Find genes that share SuperPaths with GABRQ           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GABRQ
        Sperm Motility
    Akt Signaling

    1 Tocris Bioscience Pathway for GABRQ
        Akt Pathway



    5 Kegg Pathways  (Kegg details for GABRQ):
        Neuroactive ligand-receptor interaction
    Retrograde endocannabinoid signaling
    GABAergic synapse
    Morphine addiction
    Nicotine addiction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GABRQ: 
              Neurotransmitter Receptors in human mouse rat
              GABA & Glutamate in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GABRQ

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006811ion transport ----
    GO:0006836neurotransmitter transport TAS10449790
    GO:0007165signal transduction TAS10449790

    Find genes that share ontologies with GABRQ           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GABRQ available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (+)-BicucullinePotent GABAA antagonist[485-49-4]
    MuscimolPotent GABAA agonist[2763-96-4]
    (-)-Bicuculline methiodideWater-soluble GABAA antagonist[40709-69-1]
    (-)-Bicuculline methochlorideWater-soluble GABAA antagonist[53552-05-9]
    SR 95531 hydrobromide Selective, competitive GABAA receptor antagonist [104104-50-9]

    2 HMDB Compounds for GABRQ    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    Gamma-Aminobutyric acid3-Carboxypropylamine (see all 27)56-12-2--

    Selected DrugBank Compounds for GABRQ (see all 14)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Lorazepam(+/-)-Lorazepam (see all 3)846-49-1targetpotentiator20138190 18384456 11752090
    Chlordiazepoxide-- 58-25-3targetpotentiator18384456 11752090
    ClobazamAedon (see all 23)22316-47-8targetpotentiator18384456 11752090
    ClonazepamChlonazepam (see all 2)1622-61-3targetpotentiator18384456 11752090
    Clorazepate-- 23887-31-2targetpotentiator18384456 11752090
    Diazepam-- 439-14-5targetpotentiator18384456 11752090
    Flurazepam-- 17617-23-1targetpotentiator18384456 11752090
    MidazolamDea No. 2884 (see all 4)59467-70-8targetpotentiator18384456 11752090
    Nitrazepam1, 3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one (see all 8)146-22-5targetpotentiator18384456 11752090
    OxazepamOxazipam (see all 3)604-75-1targetpotentiator18384456 11752090

    2 IUPHAR Ligands for GABRQ (theta)    About this table
    LigandTypeActionAffinityPubmed IDs
    TBPS
    Channel blockerNone--
    picrotoxin
    Channel blockerNone--

    1 PharmGKB related drug/compound annotation for GABRQ gene    About this table
    Drug/compound PharmGKB Annotation
    venlafaxineCA  



    Find genes that share compounds with GABRQ           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GABRQ gene: 
    NM_018558.3  

    Unigene Cluster for GABRQ:

    Gamma-aminobutyric acid (GABA) A receptor, theta
    Hs.283081  [show with all ESTs]
    Unigene Representative Sequence: NM_018558
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000370306(uc004ffp.1)
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    Additional mRNA sequence: 

    AF144648.1 AF189259.1 BC109210.1 BC109211.1 U47334.1 

    1 DOTS entry:

    DT.92067225 

    5 AceView cDNA sequences:

    NM_018558 BU553845 AF189259 AF144648 BF934691 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GABRQ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAAGAGAA
    GABRQ Expression
    About this image


    GABRQ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
    GABRQ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GABRQ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.283081
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GABRQ: 
              Neurotransmitter Receptors in human mouse rat
              GABA & Glutamate in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABRQ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GABRQ gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gabrq1 , 5 gamma-aminobutyric acid (GABA) A receptor, subunit more1, 5 82.08(n)1
    78.88(a)1
      X (37.29 cM)5
    572491  NM_020488.11  NP_065234.11 
     728251785 
    chicken
    (Gallus gallus)
    Aves GABRB46
    Gamma-aminobutyric acid receptor subunit beta-4
    43(a)
    many ↔ many
    4(10622204-10691620)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    45(a)
    many ↔ many
    GL343376.1(921505-946420)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-169l5.36
    si:dkey-169l5.3
    40(a)
    many ↔ many
    21(35188929-35290092) ENSDARG00000015530
    fruit fly
    (Drosophila melanogaster)
    Insecta Rdl3 response to cyclodiene GABA-A receptor 40(a)   3 67A1   --
    worm
    (Caenorhabditis elegans)
    Secernentea gbr-43 gamma-aminobutyric-acid receptor
    (beta-1 subunit)
    32(a)
    (best of 6)
      II(10699940-10702298)   --


    ENSEMBL Gene Tree for GABRQ (if available)
    TreeFam Gene Tree for GABRQ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GABRQ gene
    GLRA22  GABRR12  GLRA12  GLRB2  GABRB12  GABRR32  GABRD2  GLRA42  
    GABRP2  GABRB32  GABRB22  GLRA32  GABRR22  
    Selected SIMAP similar genes for GABRQ using alignment to 1 protein entry:     GBRT_HUMAN(see all similar genes):
    GABRB2    GABRB3    GABRB1    DKFZp781L0846    GABRR2    GABRD
    GABRR3    GLRA3    GABRP    GABRR1    GLRA2    GLRA4
    GABRA6    GLRA1    GABRG1    GABRG2    GLRB    GABRA2

    Find genes that share paralogs with GABRQ           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GABRQ (see all 329)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1851396911,2
    --151671451(+) GCAAAC/TAAGGA 1 -- us2k10--------
    rs1433261281,2
    --151671539(+) CTCATA/CTGTGA 1 -- us2k10--------
    rs1898503441,2
    --151671551(+) CCTGAC/GAAATG 1 -- us2k10--------
    rs1143440321,2
    C--151671636(+) TCTGCC/TCATTA 1 -- us2k10--------
    rs1394100401,2
    C--151671728(+) TTAAAC/TCCTCA 1 -- us2k10--------
    rs1498898581,2
    C--151671787(+) ACCAGC/TAATCT 1 -- us2k10--------
    rs45624911,2
    C,F,A,H--151672102(+) GGCAGA/TGTCTG 1 -- us2k16Minor allele frequency- T:0.08NS NA WA 254
    rs1826775231,2
    --151672181(+) CAGGAA/GCATTG 1 -- us2k10--------
    rs1398757211,2
    C--151672251(+) TTTTTA/TCCCCT 1 -- us2k10--------
    rs1432316701,2
    --151672344(+) GAGCCC/TTTCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GABRQ (151806637 - 151825999 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for GABRQ: --
    Locus Specific Mutation Databases (LSDB): GABRQ

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GABRQ
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300349    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for GABRQ:
    Essential tremor

    Find genes that share disorders with GABRQ           About GenesLikeMe

    Genetic Association Database (GAD): GABRQ
    Human Genome Epidemiology (HuGE) Navigator: GABRQ (8 documents)

    Export disorders for GABRQ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GABRQ gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with GABRQ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GABAA receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus. (PubMed id 10804200)1, 2, 3 Sinkkonen S.T.... Korpi E.R. (J. Neurosci. 2000)
    2. Theta, a novel gamma-aminobutyric acid type A receptor subunit. (PubMed id 10449790)1, 2, 3 Bonnert T.P.... Whiting P.J. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    3. Investigation of gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility. (PubMed id 19087248)1, 4, 9 Fernandez F....Griffiths L.R. (BMC Med. Genet. 2008)
    4. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    5. Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype. (PubMed id 19078961)1, 4 Craddock N....O'Donovan M.C. (Mol. Psychiatry 2010)
    6. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (BMC Biol. 2009)
    7. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Analysis of the effects of rare variants on splicing identifies alterations in GABAA receptor genes in autism spectrum disorder individuals. (PubMed id 23169495)1 Piton A....Rouleau G.A. (Eur. J. Hum. Genet. 2013)
    10. GABA stimulates human hepatocellular carcinoma growth through overexpressed GABAA receptor theta subunit. (PubMed id 22690081)1 Li Y.H....Li G.C. (World J. Gastroenterol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 55879 HGNC: 14454 AceView: GABRQ Ensembl:ENSG00000147402 euGenes: HUgn55879
    ECgene: GABRQ Kegg: 55879 H-InvDB: GABRQ

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GABRQ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for GABRQ gene:
    Search GeneIP for patents involving GABRQ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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