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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GABRQ Gene

protein-coding   GIFtS: 61
GCID: GC0XP151806

Gamma-Aminobutyric Acid (GABA) A Receptor, Theta

(Previous names: gamma-aminobutyric acid (GABA) receptor, theta)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Gamma-Aminobutyric Acid (GABA) A Receptor, Theta1 2     theta1
GABA(A) Receptor Subunit Theta2 3     THETA2
GABA(A) Receptor1     Gamma-Aminobutyric Acid Receptor Subunit Theta2
Gamma-Aminobutyric Acid (GABA) Receptor, Theta1     

External Ids:    HGNC: 144541   Entrez Gene: 558792   Ensembl: ENSG000001474027   OMIM: 3003495   UniProtKB: Q9UN883   

Export aliases for GABRQ gene to outside databases

Previous GC identifers: GC0XP146146 GC0XP148463 GC0XP149554 GC0XP150424 GC0XP151477 GC0XP140659


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GABRQ Gene:
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest
inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A
receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and
epsilon subunits of the GABA A receptor. This gene location is also the candidate region of two different
neurologic diseases: early-onset parkinsonism (Waisman syndrome) and X-linked mental retardation (MRX3).
(provided by RefSeq, Nov 2009)

GeneCards Summary for GABRQ Gene: 
GABRQ (gamma-aminobutyric acid (GABA) A receptor, theta) is a protein-coding gene. Diseases associated with GABRQ include neurologic diseases, and essential tremor, and among its related super-pathways are Morphine addiction and p38 Signaling. GO annotations related to this gene include transmembrane signaling receptor activity and extracellular ligand-gated ion channel activity. An important paralog of this gene is GLRA2.

UniProtKB/Swiss-Prot: GBRT_HUMAN, Q9UN88
Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by
binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

summary for GABRQ Gene:
GABAA receptors are members of the cys-loop family of ligand-gated ion channels, responsible for mediating
the inhibitory effects of GABA alongside GABAB and GABAC receptors. They are pentameric proteins, consisting
of 5 subunits belonging to different families (alpha1-6, beta1-3, gamma1-3, delta, pi, epsilon, rho, theta).
The most abundant GABAA receptor in the mammalian brain consist of two copies each of alpha1 and beta2 with
a single gamma2 subunits. GABAA receptors contain an integral chloride channel, and have modulatory sites
for benzodiazepines, barbiturates, neurosteroids and ethanol.

Gene Wiki entry for GABRQ Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_167198.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GABRQ gene promoter:
         C/EBPbeta   p53   NCX/Ncx   ATF-2   CUTL1   GATA-1   E47   AREB6   CRE-BP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGABRQ promoter sequence
   Search SABiosciences Chromatin IP Primers for GABRQ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GABRQ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

GABRQ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GABRQ gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP151806:  view genomic region     (about GC identifiers)

Start:
151,806,637 bp from pter      End:
151,825,999 bp from pter
Size:
19,363 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GBRT_HUMAN, Q9UN88 (See protein sequence)
Recommended Name: Gamma-aminobutyric acid receptor subunit theta precursor  
Size: 632 amino acids; 72022 Da
Subunit: Generally pentameric. This subunit coassembles with alpha-2, beta-1 and gamma-1
Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell
membrane; Multi-pass membrane protein
Secondary accessions: A6NFN1 Q32MB4 Q9NZK8

Explore the universe of human proteins at neXtProt for GABRQ: NX_Q9UN88

Explore proteomics data for GABRQ at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UN88

  • GABRQ Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GABRQ Protein Expression
    REFSEQ proteins: NP_061028.3  
    ENSEMBL proteins: 
     ENSP00000359329  

    Human Recombinant Protein Products for GABRQ: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS10449790
    GO:0016020membrane ----
    GO:0016021integral to membrane ----
    GO:0030054cell junction IEA--
    GO:0034707chloride channel complex IEA--

    GABRQ for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GABRA: Ligand-gated ion channels / GABA(A) receptors
    GABR: GABA receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: &theta 
    GABAA receptors

    5/6 InterPro protein domains (see all 6):
     IPR008101 GABAAt_rcpt
     IPR018000 Neurotransmitter_ion_chnl_CS
     IPR006028 GABAA_rcpt
     IPR006201 Neur_channel
     IPR006202 Neur_chan_lig-bd

    Graphical View of Domain Structure for InterPro Entry Q9UN88

    ProtoNet protein and cluster: Q9UN88

    3 Blocks protein domains:
    IPB006028 Gamma-aminobutyric acid A (GABAA) receptor signature
    IPB006201 Neurotransmitter-gated ion-channel
    IPB008101 Gamma-aminobutyric-acid A receptor theta subunit signature


    UniProtKB/Swiss-Prot: GBRT_HUMAN, Q9UN88
    Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC
    1.A.9.5) subfamily. GABRQ sub-subfamily


    GABRQ for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBRT_HUMAN, Q9UN88
    Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by
    binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS10449790
    GO:0004890GABA-A receptor activity IEA--
    GO:0005230extracellular ligand-gated ion channel activity IEA--
    GO:0005254chloride channel activity IEA--
    GO:0005326neurotransmitter transporter activity TAS10449790
         
    GABRQ for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for GABRQ:
     Cell cycle / mitosis defect  G0/1 arrest  Increased G1 DNA content  Metaphase cells 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Gabrq):
     nervous system 

    GABRQ for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GABRQ 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GABRQ

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GABRQ 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GABRQ 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GABRQ About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Circadian entrainment
    GABAergic synapse0.53
    Retrograde endocannabinoid signaling0.51
    Morphine addiction0.53
    2Akt Signaling
    Akt Signaling0.60
    3Apoptosis Pathway
    Akt Pathway0.39
    4Sweet Taste Signaling
    Sperm Motility0.37
    5Class A/1 (Rhodopsin-like receptors)
    Neuroactive ligand-receptor interaction0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for GABRQ
        GABA signaling in brain

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GABRQ
        Sperm Motility
    Akt Signaling

    1 Tocris Bioscience Pathway for GABRQ
        Akt Pathway



    5         Kegg Pathways  (Kegg details for GABRQ):
        Neuroactive ligand-receptor interaction
    Retrograde endocannabinoid signaling
    GABAergic synapse
    Morphine addiction
    Nicotine addiction


    GABRQ for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GABRQ

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006811ion transport ----
    GO:0006836neurotransmitter transport TAS10449790
    GO:0007165signal transduction TAS10449790

    GABRQ for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GABRQ for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Compounds for GABRQ available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (+)-BicucullinePotent GABAA antagonist[485-49-4]
    MuscimolPotent GABAA agonist[2763-96-4]
    (-)-Bicuculline methiodideWater-soluble GABAA antagonist[40709-69-1]
    (-)-Bicuculline methochlorideWater-soluble GABAA antagonist[53552-05-9]
    SR 95531 hydrobromide Selective, competitive GABAA receptor antagonist [104104-50-9]

    2 HMDB Compounds for GABRQ    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    Gamma-Aminobutyric acid3-Carboxypropylamine (see all 27)56-12-2--

    10/14 DrugBank Compounds for GABRQ (see all 14)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Lorazepam(+/-)-Lorazepam (see all 3)846-49-1targetpotentiator20138190 18384456 11752090
    Chlordiazepoxide-- 58-25-3targetpotentiator18384456 11752090
    ClobazamAedon (see all 23)22316-47-8targetpotentiator18384456 11752090
    ClonazepamChlonazepam (see all 2)1622-61-3targetpotentiator18384456 11752090
    Clorazepate-- 23887-31-2targetpotentiator18384456 11752090
    Diazepam-- 439-14-5targetpotentiator18384456 11752090
    Flurazepam-- 17617-23-1targetpotentiator18384456 11752090
    MidazolamDea No. 2884 (see all 4)59467-70-8targetpotentiator18384456 11752090
    Nitrazepam1, 3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one (see all 8)146-22-5targetpotentiator18384456 11752090
    OxazepamOxazipam (see all 3)604-75-1targetpotentiator18384456 11752090

    2 IUPHAR Ligands for GABRQ (&theta)    About this table 
    LigandTypeActionAffinityPubmed IDs
    TBPS
    Channel blocker--
    picrotoxin
    Channel blockerNone--

    1 PharmGKB related drug/compound annotation for GABRQ gene    About this table
    Drug/compound PharmGKB Annotation
    venlafaxineCA  

    Search CenterWatch for drugs/clinical trials and news about GABRQ / GBRT

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GABRQ gene: 
    NM_018558.3  

    Unigene Cluster for GABRQ:

    Gamma-aminobutyric acid (GABA) A receptor, theta
    Hs.283081  [show with all ESTs]
    Unigene Representative Sequence: NM_018558
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000370306(uc004ffp.1)

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    Additional mRNA sequence: 

    AF144648.1 AF189259.1 BC109210.1 BC109211.1 U47334.1 

    1 DOTS entry:

    DT.92067225 

    5 AceView cDNA sequences:

    BU553845 NM_018558 AF189259 AF144648 BF934691 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GABRQ expression in normal human tissues (normalized intensities)      GABRQ embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAAGAGAA
    GABRQ Expression
    About this image


    GABRQ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)
     
     Brain (Nervous System)
             hypothalamus   

    See GABRQ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GABRQ

    SOURCE GeneReport for Unigene cluster: Hs.283081
        SABiosciences Expression via Pathway-Focused PCR Arrays including GABRQ: 
              Neurotransmitter Receptors in human mouse rat
              GABA & Glutamate in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABRQ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for GABRQ gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gabrq1 , 5 gamma-aminobutyric acid (GABA) A receptor, subunit more1, 5 82.03(n)1
    78.72(a)1
      X (37.29 cM)5
    572491  NM_020488.11  NP_065234.11 
     728251785 


    ENSEMBL Gene Tree for GABRQ (if available)
    TreeFam Gene Tree for GABRQ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GABRQ gene
    GLRA22  GABRR12  GLRA12  GLRB2  GABRB12  GABRD2  GABRP2  GLRA42  
    GABRB32  GABRB22  GLRA32  GABRR22  
    18/19 SIMAP similar genes for GABRQ using alignment to 1 protein entry:     GBRT_HUMAN(see all similar genes):
    GABRB2    GABRB3    GABRB1    DKFZp781L0846    GABRR2    GABRD
    GABRR3    GLRA3    GABRP    GABRR1    GLRA2    GLRA4
    GABRA6    GLRA1    GABRG1    GABRG2    GLRB    GABRA2

    GABRQ for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/329 SNPs in GABRQ are shown (see all 329)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1851396911,2
    --151671451(+) GCAAAC/TAAGGA 1 -- us2k10--------
    rs1433261281,2
    --151671539(+) CTCATA/CTGTGA 1 -- us2k10--------
    rs1898503441,2
    --151671551(+) CCTGAC/GAAATG 1 -- us2k10--------
    rs1143440321,2
    C--151671636(+) TCTGCC/TCATTA 1 -- us2k10--------
    rs1394100401,2
    C--151671728(+) TTAAAC/TCCTCA 1 -- us2k10--------
    rs1498898581,2
    C--151671787(+) ACCAGC/TAATCT 1 -- us2k10--------
    rs45624911,2
    C,F,A,H--151672102(+) GGCAGA/TGTCTG 1 -- us2k16Minor allele frequency- T:0.08NS NA WA 254
    rs1826775231,2
    --151672181(+) CAGGAA/GCATTG 1 -- us2k10--------
    rs1398757211,2
    C--151672251(+) TTTTTA/TCCCCT 1 -- us2k10--------
    rs1432316701,2
    --151672344(+) GAGCCC/TTTCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GABRQ (151806637 - 151825999 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for GABRQ: --

    Locus Specific Mutation Databases (LSDB): GABRQ
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300349    OMIM disorders: --

    10 diseases for GABRQ:    About MalaCards
    neurologic diseases    essential tremor    tremor    anorexia nervosa
    migraine    bipolar disorder    mental retardation    alcoholism
    hepatocellular carcinoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for GABRQ:
    Essential tremor

    GABRQ for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): GABRQ
    Human Genome Epidemiology (HuGE) Navigator: GABRQ (8 documents)

    Export disorders for GABRQ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GABRQ gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with GABRQ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GABAA receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus. (PubMed id 10804200)1, 2, 3 Sinkkonen S.T.... Korpi E.R. (2000)
    2. Theta, a novel gamma-aminobutyric acid type A receptor subunit. (PubMed id 10449790)1, 2, 3 Bonnert T.P.... Whiting P.J. (1999)
    3. Investigation of gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility. (PubMed id 19087248)1, 4, 9 Fernandez F....Griffiths L.R. (2008)
    4. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    5. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (2009)
    6. Strong genetic evidence for a selective influence of GABA(A) receptors on a component of the bipolar disorder phenotype. (PubMed id 19078961)1, 4 Craddock N....O'Donovan M.C. (2008)
    7. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. GABA stimulates human hepatocellular carcinoma growth through overexpressed GABAA receptor theta subunit. (PubMed id 22690081)1 Li Y.H....Li G.C. (2012)
    10. Gamma-aminobutyric acid GABRA4, GABRE, and GABRQ rece ptor polymorphisms and risk for essential tremor. (PubMed id 21422964)1 GarcA-a-MartA-n E....JimAcnez-JimAcnez F.J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55879 HGNC: 14454 AceView: GABRQ Ensembl:ENSG00000147402 euGenes: HUgn55879
    ECgene: GABRQ Kegg: 55879 H-InvDB: GABRQ

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GABRQ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GABRQ gene:
    Search GeneIP for patents involving GABRQ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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