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Aliases & Descriptions for GABRP
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| MGC126386 2 | | MGC126387 2 | | OTTHUMP00000161000 2 |
| | | Descriptions |
|---|
| GABA(A) receptor subunit pi 3 | | gamma-aminobutyric acid (GABA) A receptor, pi 2 | | gamma-aminobutyric acid A receptor, pi 1 |
|
| | Search outside databases for aliases for GABRP genePrevious GC identifers: GC05P170445 GC05P170913 GC05P170146 GC05P170191 |
Summaries for GABRP(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for GABRP: The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. [provided by RefSeq] UniProtKB/Swiss-Prot: GBRP_HUMAN, O00591Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanoloneGene Wiki entry for GABRP |
Genomic Location for GABRP
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the GABRP gene 
Entrez Gene cytogenetic band: 5q33-q34 Ensembl cytogenetic band: 5q35.1 HGNC cytogenetic band: 5q33-q34GABRP Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P170143:
(about GC identifiers)
Start:
|
170,142,275 bp from pter |
End:
|
170,173,629 bp from pter |
Size:
|
31,355 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000005.8 NT_023133.12
| Proteins for GABRP
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: GBRP_HUMAN, O00591 (See
protein sequence)Recommended Name: Gamma-aminobutyric acid receptor subunit pi precursor Size: 440 amino acids; 50640 Da
Subunit: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and epsilon. A sixth class of subunit: Rho form homomeric GABA receptors that do not appear to coexist with GABA(A) receptor subunits but with GABA(C) receptor subunits. Subunit Pi can also bind this complex
Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Secondary accessions: Q32MJ1REFSEQ proteins: NP_055026.1
ENSEMBL proteins: ENSP00000377423 ENSP00000265294
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for GABRP: Assays for GABRP: | Protein
Domains/ Families for GABRP(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O00591
ProtoNet protein and cluster: O00591 3 Blocks protein families: IPB006028 Gamma-aminobutyric acid A (GABAA) receptor signature IPB006201 Neurotransmitter-gated ion-channel IPB008100 Gamma-aminobutyric-acid A receptor pi subunit signature
UniProtKB/Swiss-Prot: GBRP_HUMAN, O00591Similarity: Belongs to the ligand-gated ionic channel (TC 1.A.9) family | Gene Function for GABRP
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014211
Applied Biosystems Silencer® siRNAs for GABRP
Sigma-Aldrich siRNA and siRNA Panels for GABRP  Sigma-Aldrich shRNA for GABRP  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014211                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014211                                  untagged cDNA clone in CMV expression vector: NM_014211 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014211
UniProtKB/Swiss-Prot: GBRP_HUMAN, O00591Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Gabrp):
5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): About this table | Pathways & Interactions for GABRP
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Sigma-Aldrich "Your Favorite Gene" Pathway for GABRP (Your Favorite Gene powered by Ingenuity) 
5/17 Interacting proteins for GABRP (ENSP000002652943) via UniProtKB, MINT, and/or STRING (see all 17
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006811 | ion transport |
IEA | -- | About this table
|
Drugs & Compounds for GABRP(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for GABRP |
Compounds for GABRP available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| Muscimol | Potent GABAA agonist | [2763-96-4] | | (+)-Bicuculline | Potent GABAA antagonist | [485-49-4] | | Indiplon | Subtype-selective GABAA receptor positive allosteric modulator | [325715-02-4] | | L-655,708 | Selective for alpha5-containing GABAA receptors | [130477-52-0] | | SR 95531 hydrobromide | Selective, competitive GABAA receptor antagonist | [104104-50-9] | About this table
|
Transcripts for GABRP(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014211
Sigma-Aldrich siRNA and siRNA Panels for GABRP  Sigma-Aldrich shRNA for GABRP  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_014211 REFSEQ mRNAs for GABRP gene: NM_014211.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014211               OriGene GFP tagged cDNA clone in CMV expression vector: NM_014211                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014211                                  untagged cDNA clone in CMV expression vector: NM_014211  Additional cDNA sequence: AK055205.1 AK292901.1 AK296805.1 AK300303.1 BC074810.2 BC074865.2 BC109105.1 BC109106.1 CR599634.1 U95367.1 7 DOTS entries: DT.452502 DT.102831011 DT.102831012 DT.120831620 DT.100034267 DT.120831628 DT.75118728 24/96 AceView cDNA sequences (see all 96
):CR599634 BC074865 AI560906 AL708685 AI075074 AI912873 AI619885 AW439792 AW169065 CA312543 AI446810 AI334802 AW438575 BC074810 BX509618 AU130953 AI521015 BU679207 AW959225 U95367 CB243579 CB047841 AA120821 CD696885
highest scoring ESTs for GABRP:U95367 AA101225 AA120822 AA294978 AA298878 AA559040 AI075074 AI334802 AI446810 AI521015 Unigene Cluster for GABRP: Gamma-aminobutyric acid (GABA) A receptor, pi Hs.26225 [show with all ESTs]Unigene Representative Sequence: NM_014211
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for GABRP
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for GABRP
2 Ensembl transcripts including schematic representations: ENST00000393840
ENST00000265294
|
Expression for GABRP
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| GABRP expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for GABRP
1 / 2 / 3 3 probe-sets matching GABRP gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AGCAGGAGCG
SOURCE GeneReport for Unigene cluster: Hs.26225
Expression variation in blood from EXPOLDB for GABRP UniProtKB/Swiss-Prot: GBRP_HUMAN, O00591Tissue specificity: Most abundant in the uterus, also expressed in lung, thymus and prostate |
Orthologs for GABRP
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GABRP gene from 5/7 species (see all 7
)
About this table Species with no ortholog for GABRP
ENSEMBL Gene Tree for GABRP | Paralogs for GABRP(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for GABRP gene
- GABRD2 GABRQ2
|
SNPs/Variants for GABRP(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for GABRP (up to first 250kb)
|
Disorders & Mutations for GABRP
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602729
Genetic Association Database: GABRP Human Genome Epidemiology Navigator: GABRP (5 documents)
|
Medical News for GABRP(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for GABRP (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/17 PubMed articles for GABRP gene (see all 17
): |
Search for GABRP
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing GABRP
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing GABRP
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GABRP(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for GABRP(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for GABRP:

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|
 |  |  |
| | | | Tocris compounds for GABRP |
|
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|