Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GABRP Gene

protein-coding   GIFtS: 63
GCID: GC05P170143

Gamma-Aminobutyric Acid (GABA) A Receptor, Pi

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Gamma-Aminobutyric Acid (GABA) A Receptor, Pi1 2
GABA(A) Receptor Subunit Pi2 3
GABA(A) Receptor1
pi1
GABA(A) Receptor, Pi2
Gamma-Aminobutyric Acid Receptor Subunit Pi2

External Ids:    HGNC: 40891   Entrez Gene: 25682   Ensembl: ENSG000000947557   OMIM: 6027295   UniProtKB: O005913   

Export aliases for GABRP gene to outside databases

Previous GC identifers: GC05P170445 GC05P170913 GC05P170146 GC05P170191 GC05P165308


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GABRP Gene:
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest
inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in
several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A
receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory
agents such as pregnanolone. (provided by RefSeq, Jul 2008)

GeneCards Summary for GABRP Gene:
GABRP (gamma-aminobutyric acid (GABA) A receptor, pi) is a protein-coding gene. GO annotations related to this gene include chloride channel activity and GABA-A receptor activity. An important paralog of this gene is GLRA2.

UniProtKB/Swiss-Prot: GBRP_HUMAN, O00591
Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by
binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function
of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A)
receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone

summary for GABRP Gene:
GABAA receptors are members of the cys-loop family of ligand-gated ion channels, responsible for mediating
the inhibitory effects of GABA alongside GABAB and GABAC receptors. They are pentameric proteins, consisting
of 5 subunits belonging to different families (alpha1-6, beta1-3, gamma1-3, delta, pi, epsilon, rho, theta).
The most abundant GABAA receptor in the mammalian brain consist of two copies each of alpha1 and beta2 with
a single gamma2 subunits. GABAA receptors contain an integral chloride channel, and have modulatory sites
for benzodiazepines, barbiturates, neurosteroids and ethanol.

Gene Wiki entry for GABRP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_023133.14  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GABRP gene promoter:
         Max1   Sox5   RFX1   Evi-1   SRY   FOXJ2 (long isoform)   STAT3   FOXJ2   TGIF   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGABRP promoter sequence
   Search Chromatin IP Primers for GABRP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GABRP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.1   Ensembl cytogenetic band:  5q35.1   HGNC cytogenetic band: 5q35.1

GABRP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GABRP gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P170143:  view genomic region     (about GC identifiers)

Start:
170,190,354 bp from pter      End:
170,241,051 bp from pter
Size:
50,698 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GBRP_HUMAN, O00591 (See protein sequence)
Recommended Name: Gamma-aminobutyric acid receptor subunit pi precursor  
Size: 440 amino acids; 50640 Da
Subunit: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and
epsilon. A sixth class of subunit: Rho form homomeric GABA receptors that do not appear to coexist with GABA(A)
receptor subunits but with GABA(C) receptor subunits. Subunit Pi can also bind this complex
Secondary accessions: A8KA36 D3DQL2 Q32MJ1

Explore the universe of human proteins at neXtProt for GABRP: NX_O00591

Explore proteomics data for GABRP at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn43, Asn102, Asn145, Asn196, Asn228

  • See GABRP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055026.1  
    ENSEMBL proteins: 
     ENSP00000428804   ENSP00000428103   ENSP00000429668   ENSP00000430188   ENSP00000430100  
     ENSP00000429815   ENSP00000430727   ENSP00000430772   ENSP00000265294  

    GABRP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GABRP
    GenScript Custom Purified and Recombinant Proteins Services for GABRP
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GABRP 

     
    Search antibodies-online for proteins for GABRP 

     
    antibodies-online peptides for GABRP

    GABRP Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GABRP
    Novus Biologicals GABRP Antibody
    Abcam antibodies for GABRP
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for GABRP
    antibodies-online antibodies for GABRP (22 products) 

    GABRP Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GABRP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GABRP
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for GABRP 
    antibodies-online kits for GABRP (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    GABRA: Ligand-gated ion channels / GABA(A) receptors
    GABR: GABA receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: pi
    GABAA receptors

    Selected InterPro protein domains (see all 6):
     IPR018000 Neurotransmitter_ion_chnl_CS
     IPR006028 GABAA_rcpt
     IPR008100 GABAAp_rcpt
     IPR006201 Neur_channel
     IPR006202 Neur_chan_lig-bd

    Graphical View of Domain Structure for InterPro Entry O00591

    ProtoNet protein and cluster: O00591

    3 Blocks protein domains:
    IPB006028 Gamma-aminobutyric acid A (GABAA) receptor signature
    IPB006201 Neurotransmitter-gated ion-channel
    IPB008100 Gamma-aminobutyric-acid A receptor pi subunit signature


    UniProtKB/Swiss-Prot: GBRP_HUMAN, O00591
    Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC
    1.A.9.5) subfamily. GABRP sub-subfamily


    Find genes that share domains with GABRP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBRP_HUMAN, O00591
    Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by
    binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function
    of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A)
    receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004890GABA-A receptor activity IEA--
    GO:0005230extracellular ligand-gated ion channel activity IEA--
    GO:0005254chloride channel activity IEA--
         
    Find genes that share ontologies with GABRP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GABRP:
     Decreased POU5F1-GFP protein e 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Gabrp):
     normal 

    Find genes that share phenotypes with GABRP           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for GABRP

    miRNA
    Products:
        
    miRTarBase miRNAs that target GABRP:
    hsa-mir-335-5p (MIRT016992)

    Block miRNA regulation of human, mouse, rat GABRP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GABRP (see all 13):
    hsa-miR-548am hsa-miR-125a-3p hsa-miR-27a hsa-miR-2110 hsa-miR-3918 hsa-miR-3150a-3p hsa-miR-617 hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidGABRP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GABRP
    Predesigned siRNA for gene silencing in human, mouse, rat GABRP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GABRP

    Clone
    Products:
         
    OriGene clones in human, mouse for GABRP (see all 7)
    OriGene ORF clones in mouse, rat for GABRP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GABRP (NM_014211)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GABRP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GABRP

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GABRP
    Browse ESI BIO Cell Lines and PureStem Progenitors for GABRP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABRP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GBRP_HUMAN, O00591: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell
    membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    lysosome1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ----
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0030054cell junction IEA--
    GO:0034707chloride channel complex IEA--

    Find genes that share ontologies with GABRP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GABRP About    
    See pathways by source

    SuperPathContained pathways About
    1Circadian entrainment
    GABAergic synapse0.53
    Retrograde endocannabinoid signaling0.51
    Morphine addiction0.53
    2Peptide ligand-binding receptors
    Neuroactive ligand-receptor interaction0.36
    3GABA signaling in brain
    GABA signaling in brain0.32
    4Nicotine addiction
    Nicotine addiction


    Find genes that share SuperPaths with GABRP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5 Kegg Pathways  (Kegg details for GABRP):
        Neuroactive ligand-receptor interaction
    Retrograde endocannabinoid signaling
    GABAergic synapse
    Morphine addiction
    Nicotine addiction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GABRP
    Interactions:

        Search GeneGlobe Interaction Network for GABRP

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006811ion transport ----
    GO:0007165signal transduction TAS9182563

    Find genes that share ontologies with GABRP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GABRP available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (+)-BicucullinePotent GABAA antagonist[485-49-4]
    MuscimolPotent GABAA agonist[2763-96-4]
    (-)-Bicuculline methiodideWater-soluble GABAA antagonist[40709-69-1]
    (-)-Bicuculline methochlorideWater-soluble GABAA antagonist[53552-05-9]
    SR 95531 hydrobromide Selective, competitive GABAA receptor antagonist [104104-50-9]

    2 HMDB Compounds for GABRP    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    Gamma-Aminobutyric acid3-Carboxypropylamine (see all 27)56-12-2--

    Selected DrugBank Compounds for GABRP (see all 22)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Lorazepam(+/-)-Lorazepam (see all 3)846-49-1targetpotentiator20138190 18384456 11752090
    Adinazolam-- 37115-32-5targetpotentiator6320036 6148400
    Chlordiazepoxide-- 58-25-3targetpotentiator18384456 11752090
    ClobazamAedon (see all 23)22316-47-8targetpotentiator18384456 11752090
    ClonazepamChlonazepam (see all 2)1622-61-3targetpotentiator18384456 11752090
    Clorazepate-- 23887-31-2targetpotentiator18384456 11752090
    Diazepam-- 439-14-5targetpotentiator18384456 11752090
    Estazolam-- 29975-16-4targetpotentiator639854 2889803
    Flurazepam-- 17617-23-1targetpotentiator18384456 11752090
    Halazepam-- 23092-17-3targetpotentiator2867566 6738302

    2 IUPHAR Ligands for GABRP (pi)    About this table
    LigandTypeActionAffinityPubmed IDs
    TBPS
    Channel blockerNone--
    picrotoxin
    Channel blockerNone--

    3 PharmGKB related drug/compound annotations for GABRP gene    About this table
    Drug/compound PharmGKB Annotation
    Selective serotonin reuptake inhibitorsCA  
    antidepressantsCA  
    venlafaxineCA  



    Find genes that share compounds with GABRP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GABRP gene: 
    NM_014211.2  

    Unigene Cluster for GABRP:

    Gamma-aminobutyric acid (GABA) A receptor, pi
    Hs.26225  [show with all ESTs]
    Unigene Representative Sequence: NM_014211
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521481 ENST00000521009 ENST00000519196 ENST00000522868 ENST00000518525
    ENST00000518122 ENST00000519385 ENST00000519598 ENST00000519137 ENST00000265294(uc003mau.3 uc011dev.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GABRP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GABRP (see all 13):
    hsa-miR-548am hsa-miR-125a-3p hsa-miR-27a hsa-miR-2110 hsa-miR-3918 hsa-miR-3150a-3p hsa-miR-617 hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidGABRP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GABRP
    Predesigned siRNA for gene silencing in human, mouse, rat GABRP
    Clone
    Products:
         
    OriGene clones in human, mouse for GABRP (see all 7)
    OriGene ORF clones in mouse, rat for GABRP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GABRP (NM_014211)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GABRP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GABRP
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GABRP
    OriGene qSTAR qPCR primer pairs in human, mouse for GABRP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GABRP
      QuantiTect SYBR Green Assays in human, mouse, rat GABRP
      QuantiFast Probe-based Assays in human, mouse, rat GABRP

    Additional mRNA sequence: 

    AK055205.1 AK292901.1 AK296805.1 AK300303.1 BC074810.2 BC074865.2 BC109105.1 BC109106.1 
    U95367.1 

    7 DOTS entries:

    DT.452502  DT.102831011  DT.120831620  DT.100034267  DT.102831012  DT.120831628  DT.75118728 

    Selected AceView cDNA sequences (see all 96):

    AI912873 AI075074 CR599634 BU679207 AI446810 AW438575 AL708685 AI334802 
    BX509618 CA312543 BC074810 AI619885 AI521015 AW169065 AI560906 AU130953 
    AW439792 BC074865 AI740841 CD696885 CB306461 AK055205 CB243579 BV199350 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GABRP    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                                              -               


    ECgene alternative splicing isoforms for GABRP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GABRP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCAGGAGCG
    GABRP Expression
    About this image


    GABRP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Duct Cells Pancreatic Ducts
             Islets of Langerhans
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             Hepatocyte-like cells
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
    GABRP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GABRP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.26225

    UniProtKB/Swiss-Prot: GBRP_HUMAN, O00591
    Tissue specificity: Most abundant in the uterus, also expressed in lung, thymus and prostate

        Custom PCR Arrays for GABRP
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GABRP
    OriGene qSTAR qPCR primer pairs in human, mouse for GABRP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GABRP
    QuantiTect SYBR Green Assays in human, mouse, rat GABRP
    QuantiFast Probe-based Assays in human, mouse, rat GABRP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABRP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for GABRP gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gabrp1 , 5 gamma-aminobutyric acid (GABA) A receptor, pi1, 5 88.86(n)1
    92.73(a)1
      11 (19.21 cM)5
    2166431  NM_146017.31  NP_666129.11 
     335507815 
    chicken
    (Gallus gallus)
    Aves GABRP1 gamma-aminobutyric acid (GABA) A receptor, pi 75.52(n)
    79.49(a)
      416174  XM_004944774.1  XP_004944831.1 
    lizard
    (Anolis carolinensis)
    Reptilia GABRP6
    gamma-aminobutyric acid (GABA) A receptor, pi
    69(a)
    1 ↔ 1
    1(129874726-129898137)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gabrp1 gamma-aminobutyric acid (GABA) A receptor, pi 63.52(n)
    62.24(a)
      100498164  XM_002937732.2  XP_002937778.2 
    zebrafish
    (Danio rerio)
    Actinopterygii gabrp1 gamma-aminobutyric acid (GABA) A receptor, pi 60.78(n)
    60.7(a)
      566633  XM_005173293.1  XP_005173350.1 


    ENSEMBL Gene Tree for GABRP (if available)
    TreeFam Gene Tree for GABRP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GABRP gene
    GLRA22  GABRR12  GLRA12  GLRB2  GABRB12  GABRR32  GABRD2  GLRA42  
    GABRB32  GABRB22  GABRQ2  GLRA32  GABRR22  
    Selected SIMAP similar genes for GABRP using alignment to 8 protein entries:     GBRP_HUMAN (see all proteins) (see all similar genes):
    GABRB3    GABRD    GLRA3    GABRR1    GABRR2    GLRA4
    GABRB1    GABRR3    DKFZp781L0846    GABRB2    GLRA1    GABRA5
    GABRA2    GABRQ    GLRA2    GABRG2    GABRA6    GABRA3

    Find genes that share paralogs with GABRP           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for GABRP
    PGOHUM00000239731


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GABRP (see all 842)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360344
    A breast cancer sample4--see VAR_0360342 H R mis40--------
    rs1398002511,2
    C,Funtested1170235729(+) CTCTCG/AATTCA 2 /N /D mis11Minor allele frequency- A:0.00NA 4550
    rs1828278321,2
    --170208753(+) CCCCTC/TCCAGG 1 -- us2k10--------
    rs1856583001,2
    --170208835(+) GAGATA/GAGACG 1 -- us2k10--------
    rs77164701,2
    C,F,A--170208839(+) TAAGAT/CGCCTT 1 -- us2k114Minor allele frequency- C:0.32NA EA WA CSA 732
    rs1465696201,2
    --170208851(+) TCATAC/TCTACT 1 -- us2k10--------
    rs1900750021,2
    --170208895(+) GGGTAA/GTCAGT 1 -- us2k10--------
    rs1412227991,2
    C--170208964(+) AAATAA/CTAACA 1 -- us2k10--------
    rs339509351,2
    C--170208995(+) ACAGG-/GATA  
            
    ATAGA
    1 -- us2k10--------
    rs582259591,2
    C--170208996(+) ATAGATAGA/-  
            
    CAGAT
    1 -- us2k11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for GABRP (170190354 - 170241051 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for GABRP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731083CNV Deletion23290073
    esv2731085CNV Deletion23290073
    nsv327390CNV Insertion16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GABRP
    DNA2.0 Custom Variant and Variant Library Synthesis for GABRP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602729    OMIM disorders: --


    Find genes that share disorders with GABRP           About GenesLikeMe

    Genetic Association Database (GAD): GABRP
    Human Genome Epidemiology (HuGE) Navigator: GABRP (8 documents)

    Export disorders for GABRP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GABRP gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with GABRP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel class of GABAA receptor subunit in tissues of the reproductive system. (PubMed id 9182563)1, 2, 3 Hedblom E. and Kirkness E.F. (J. Biol. Chem. 1997)
    2. Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder. (PubMed id 20583128)1, 4 Green E.K....Craddock N. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    3. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    4. Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype. (PubMed id 19078961)1, 4 Craddock N....O'Donovan M.C. (Mol. Psychiatry 2010)
    5. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    6. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    7. Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia. (PubMed id 16172613)1, 4 Petryshen T.L....Sklar P. (Mol. Psychiatry 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. (PubMed id 23470693)1 Zeng Z....Marazita M.L. (J. Dent. Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2568 HGNC: 4089 AceView: GABRP Ensembl:ENSG00000094755 euGenes: HUgn2568
    ECgene: GABRP Kegg: 2568 H-InvDB: GABRP

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GABRP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GABRP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GABRP gene:
    Search GeneIP for patents involving GABRP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for GABRP (GABA-A R pi)   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for GABRP  
     OriGene qPCR primer pairs and template standards for GABRP   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GABRP  
     OriGene qSTAR qPCR primer pairs in human, mouse for GABRP   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GABRP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GABRP   OriGene Custom Protein Services for GABRP  

     
     
     Block miRNA regulation of human, mouse, rat GABRP using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GABRP
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GABRP Predesigned siRNA for gene silencing in human, mouse, rat GABRP
     QuantiFast Probe-based Assays in human, mouse, rat GABRP QuantiTect SYBR Green Assays in human, mouse, rat GABRP
     Custom PCR Arrays for GABRP Search Chromatin IP Primers for GABRP
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GABRP  Search GeneGlobe Interaction Network for GABRP
     Regulatory tfbs in GABRP promoter
     GenScript Custom Purified and Recombinant Proteins Services for GABRP GenScript cDNA clones with any tag delivered in your preferred vector for GABRP
     GenScript Custom Assay Services for GABRP GenScript Custom overexpressing Cell Line Services for GABRP
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for GABRP
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GABRP antibodies
     Antibodies for GABRP
     See all of Abcam's Antibodies, Kits and Proteins for GABRP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for GABRP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABRP
     SwitchGear 3'UTR luciferase reporter plasmids for GABRP
     SwitchGear Promoter luciferase reporter plasmids for GABRP
     ThermoFisher Antibodies for GABRP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GABRP
     Browse compounds at ApexBio
     Search Addgene for plasmids for GABRP
      Search eBioscience for proteins for GABRP
      Search eBioscience for elisas for GABRP
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for GABRP
     antibodies-online antibodies for GABRP (22 products)
     antibodies-online kits for GABRP (5 products)
     antibodies-online peptides for GABRP
      Search antibodies-online for proteins for GABRP
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GABRP gene at Home site.
    Version: 3.12.248 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4