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Aliases for GABRP Gene

Aliases for GABRP Gene

  • Gamma-Aminobutyric Acid (GABA) A Receptor, Pi 2 3
  • GABA(A) Receptor Subunit Pi 4
  • GABA(A) Receptor 2
  • Pi 2

External Ids for GABRP Gene

Previous GeneCards Identifiers for GABRP Gene

  • GC05P170445
  • GC05P170913
  • GC05P170146
  • GC05P170191
  • GC05P170143
  • GC05P165308

Summaries for GABRP Gene

Entrez Gene Summary for GABRP Gene

  • The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

GeneCards Summary for GABRP Gene

GABRP (Gamma-Aminobutyric Acid (GABA) A Receptor, Pi) is a Protein Coding gene. Among its related pathways are Circadian entrainment and Peptide ligand-binding receptors. GO annotations related to this gene include chloride channel activity and GABA-A receptor activity. An important paralog of this gene is GABRR1.

UniProtKB/Swiss-Prot for GABRP Gene

  • GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone

Tocris Summary for GABRP Gene

  • GABAA receptors are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of GABA alongside GABAB and GABAC receptors. They are pentameric proteins, consisting of 5 subunits belonging to different families (alpha1-6, beta1-3, gamma1-3, delta, pi, epsilon, rho, theta). The most abundant GABAA receptor in the mammalian brain consist of two copies each of alpha1 and beta2 with a single gamma2 subunits. GABAA receptors contain an integral chloride channel, and have modulatory sites for benzodiazepines, barbiturates, neurosteroids and ethanol.

Gene Wiki entry for GABRP Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GABRP Gene

Genomics for GABRP Gene

Regulatory Elements for GABRP Gene

Genomic Location for GABRP Gene

Start:
170,763,350 bp from pter
End:
170,814,047 bp from pter
Size:
50,698 bases
Orientation:
Plus strand

Genomic View for GABRP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GABRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GABRP Gene

Proteins for GABRP Gene

  • Protein details for GABRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00591-GBRP_HUMAN
    Recommended name:
    Gamma-aminobutyric acid receptor subunit pi
    Protein Accession:
    O00591
    Secondary Accessions:
    • A8KA36
    • D3DQL2
    • Q32MJ1

    Protein attributes for GABRP Gene

    Size:
    440 amino acids
    Molecular mass:
    50640 Da
    Quaternary structure:
    • Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and epsilon. A sixth class of subunit: Rho form homomeric GABA receptors that do not appear to coexist with GABA(A) receptor subunits but with GABA(C) receptor subunits. Subunit Pi can also bind this complex

neXtProt entry for GABRP Gene

Proteomics data for GABRP Gene at MOPED

Post-translational modifications for GABRP Gene

  • Glycosylation at Asn43, Asn102, Asn145, Asn196, and Asn228
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for GABRP Gene

Domains for GABRP Gene

Gene Families for GABRP Gene

HGNC:
  • GABR :GABA receptors
  • GABRA :Ligand-gated ion channels / GABA(A) receptors
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

O00591

UniProtKB/Swiss-Prot:

GBRP_HUMAN :
  • O00591
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRP sub-subfamily.
genes like me logo Genes that share domains with GABRP: view

Function for GABRP Gene

Molecular function for GABRP Gene

UniProtKB/Swiss-Prot Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone

Gene Ontology (GO) - Molecular Function for GABRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004890 GABA-A receptor activity IEA --
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0005254 chloride channel activity IEA --
genes like me logo Genes that share ontologies with GABRP: view

Phenotypes for GABRP Gene

MGI mutant phenotypes for GABRP:
inferred from 1 alleles
GenomeRNAi human phenotypes for GABRP:
genes like me logo Genes that share phenotypes with GABRP: view

miRNA for GABRP Gene

miRTarBase miRNAs that target GABRP

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GABRP Gene

Localization for GABRP Gene

Subcellular locations from UniProtKB/Swiss-Prot for GABRP Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GABRP Gene COMPARTMENTS Subcellular localization image for GABRP gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GABRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0030054 cell junction IEA --
GO:0034707 chloride channel complex IEA --
genes like me logo Genes that share ontologies with GABRP: view

Pathways for GABRP Gene

genes like me logo Genes that share pathways with GABRP: view

Interacting Proteins for GABRP Gene

Gene Ontology (GO) - Biological Process for GABRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport --
GO:0007165 signal transduction TAS 9182563
GO:0034220 ion transmembrane transport --
GO:1902476 chloride transmembrane transport IEA --
genes like me logo Genes that share ontologies with GABRP: view

Compounds for GABRP Gene

(5) Tocris Compounds for GABRP Gene

Compound Action Cas Number
(-)-Bicuculline methiodide Water-soluble GABAA antagonist [40709-69-1]
(-)-Bicuculline methochloride Water-soluble GABAA antagonist [53552-05-9]
L-655,708 Selective for alpha5-containing GABAA receptors [130477-52-0]
Muscimol Potent GABAA agonist [2763-96-4]
SR 95531 hydrobromide Selective, competitive GABAA receptor antagonist [104104-50-9]

(2) HMDB Compounds for GABRP Gene

Compound Synonyms Cas Number PubMed IDs
Chlorine
  • Cl2
16887-00-6
Gamma-Aminobutyric acid
  • 3-Carboxypropylamine
56-12-2

(22) Drugbank Compounds for GABRP Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adinazolam
37115-32-5 target potentiator
Alprazolam
28981-97-7 target potentiator
Bromazepam
  • 7-Bromo-5-(2-pyridyl)-3H-1,4-benzodiaxepin-2(1H)-one
1812-30-2 target potentiator
Chlordiazepoxide
58-25-3 target potentiator
Cinolazepam
75696-02-5 target potentiator

(2) IUPHAR Ligand for GABRP Gene

Ligand Type Action Affinity Pubmed IDs
TBPS Channel blocker None
picrotoxin Channel blocker None

(3) PharmGKB related drug/compound annotations for GABRP Gene

genes like me logo Genes that share compounds with GABRP: view

Transcripts for GABRP Gene

Unigene Clusters for GABRP Gene

Gamma-aminobutyric acid (GABA) A receptor, pi:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GABRP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GABRP Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1:
SP2:
SP3: -

Relevant External Links for GABRP Gene

GeneLoc Exon Structure for
GABRP
ECgene alternative splicing isoforms for
GABRP

Expression for GABRP Gene

mRNA expression in normal human tissues for GABRP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GABRP Gene

This gene is overexpressed in Breast - Mammary Tissue (13.8), Esophagus - Mucosa (9.4), Minor Salivary Gland (7.1), Vagina (5.6), and Skin - Sun Exposed (Lower leg) (4.7).

SOURCE GeneReport for Unigene cluster for GABRP Gene Hs.26225

mRNA Expression by UniProt/SwissProt for GABRP Gene

O00591-GBRP_HUMAN
Tissue specificity: Most abundant in the uterus, also expressed in lung, thymus and prostate
genes like me logo Genes that share expressions with GABRP: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for GABRP Gene

Orthologs for GABRP Gene

This gene was present in the common ancestor of animals.

Orthologs for GABRP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GABRP 35
  • 91.14 (n)
  • 94.09 (a)
GABRP 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GABRP 35
  • 91.44 (n)
  • 95 (a)
GABRP 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gabrp 35
  • 88.86 (n)
  • 92.73 (a)
Gabrp 16
Gabrp 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GABRP 35
  • 99.17 (n)
  • 99.77 (a)
GABRP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gabrp 35
  • 89.02 (n)
  • 92.95 (a)
oppossum
(Monodelphis domestica)
Mammalia GABRP 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GABRP 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves GABRP 35
  • 75.52 (n)
  • 79.49 (a)
GABRP 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GABRP 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gabrp 35
  • 63.52 (n)
  • 62.24 (a)
zebrafish
(Danio rerio)
Actinopterygii gabrp 35
  • 60.78 (n)
  • 60.7 (a)
gabrp 36
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea gbr-4 37
  • 27 (a)
K10D6.1 37
  • 25 (a)
T24D8.1 37
  • 28 (a)
Species with no ortholog for GABRP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GABRP Gene

ENSEMBL:
Gene Tree for GABRP (if available)
TreeFam:
Gene Tree for GABRP (if available)

Paralogs for GABRP Gene

Pseudogenes.org Pseudogenes for GABRP Gene

genes like me logo Genes that share paralogs with GABRP: view

Variants for GABRP Gene

Sequence variations from dbSNP and Humsavar for GABRP Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs732157 -- 170,784,247(+) AGTGA(C/T)AAGGA intron-variant
rs929761 -- 170,783,757(+) ACATA(C/T)GAGGG utr-variant-5-prime
rs929762 -- 170,783,816(+) TTGCC(C/T)GGAAG utr-variant-5-prime
rs929763 -- 170,783,993(+) TAATG(A/T)GCATC intron-variant
rs975061 -- 170,797,526(+) CAGAC(A/T)TGCAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for GABRP Gene

Variant ID Type Subtype PubMed ID
esv2731083 CNV Deletion 23290073
nsv327390 CNV Insertion 16902084
esv2731085 CNV Deletion 23290073

Relevant External Links for GABRP Gene

HapMap Linkage Disequilibrium report
GABRP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GABRP Gene

Disorders for GABRP Gene

Relevant External Links for GABRP

Genetic Association Database (GAD)
GABRP
Human Genome Epidemiology (HuGE) Navigator
GABRP

No disorders were found for GABRP Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for GABRP Gene

Publications for GABRP Gene

  1. A novel class of GABAA receptor subunit in tissues of the reproductive system. (PMID: 9182563) Hedblom E. … Kirkness E.F. (J. Biol. Chem. 1997) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia. (PMID: 16172613) Petryshen T.L. … Sklar P. (Mol. Psychiatry 2005) 3 48
  5. Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype. (PMID: 19078961) Craddock N. … O'Donovan M.C. (Mol. Psychiatry 2010) 3 48

Products for GABRP Gene

Sources for GABRP Gene

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