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Aliases for GABRG3 Gene

Aliases for GABRG3 Gene

  • Gamma-Aminobutyric Acid (GABA) A Receptor, Gamma 3 2 3
  • GABA(A) Receptor Subunit Gamma-3 4
  • GABA(G) Receptor 2
  • Gamma 3 2

External Ids for GABRG3 Gene

Previous GeneCards Identifiers for GABRG3 Gene

  • GC15P023369
  • GC15P020593
  • GC15P024651
  • GC15P024779
  • GC15P024800
  • GC15P027216
  • GC15P005344

Summaries for GABRG3 Gene

Entrez Gene Summary for GABRG3 Gene

  • This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. The protein encoded by this gene is a gamma subunit, which contains the benzodiazepine binding site. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2012]

GeneCards Summary for GABRG3 Gene

GABRG3 (Gamma-Aminobutyric Acid (GABA) A Receptor, Gamma 3) is a Protein Coding gene. Among its related pathways are Akt Signaling and Apoptosis Pathway. GO annotations related to this gene include chloride channel activity and GABA-A receptor activity. An important paralog of this gene is GABRA4.

UniProtKB/Swiss-Prot for GABRG3 Gene

  • GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

Tocris Summary for GABRG3 Gene

  • GABAA receptors are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of GABA alongside GABAB and GABAC receptors. They are pentameric proteins, consisting of 5 subunits belonging to different families (alpha1-6, beta1-3, gamma1-3, delta, pi, epsilon, rho, theta). The most abundant GABAA receptor in the mammalian brain consist of two copies each of alpha1 and beta2 with a single gamma2 subunits. GABAA receptors contain an integral chloride channel, and have modulatory sites for benzodiazepines, barbiturates, neurosteroids and ethanol.

Gene Wiki entry for GABRG3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GABRG3 Gene

Genomics for GABRG3 Gene

Regulatory Elements for GABRG3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GABRG3 Gene

26,971,282 bp from pter
27,541,991 bp from pter
570,710 bases
Plus strand

Genomic View for GABRG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GABRG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GABRG3 Gene

Proteins for GABRG3 Gene

  • Protein details for GABRG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Gamma-aminobutyric acid receptor subunit gamma-3
    Protein Accession:
    Secondary Accessions:
    • G3V594
    • Q9HD46
    • Q9NYT2

    Protein attributes for GABRG3 Gene

    467 amino acids
    Molecular mass:
    54289 Da
    Quaternary structure:
    • Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho
    • This subunit carries the benzodiazepine binding site

    Alternative splice isoforms for GABRG3 Gene


neXtProt entry for GABRG3 Gene

Proteomics data for GABRG3 Gene at MOPED

Post-translational modifications for GABRG3 Gene

Other Protein References for GABRG3 Gene

Antibody Products

No data available for DME Specific Peptides for GABRG3 Gene

Domains for GABRG3 Gene

Gene Families for GABRG3 Gene

  • GABR :GABA receptors
  • GABRA :Ligand-gated ion channels / GABA(A) receptors

Suggested Antigen Peptide Sequences for GABRG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q99928
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG3 sub-subfamily.
genes like me logo Genes that share domains with GABRG3: view

Function for GABRG3 Gene

Molecular function for GABRG3 Gene

GENATLAS Biochemistry:
gamma-aminobutyric acid (GABA) A receptor,ionotropic,gamma 3,subunit,component of a pentameric receptor mediating inhibitory neurotransmission
UniProtKB/Swiss-Prot Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

Gene Ontology (GO) - Molecular Function for GABRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004890 GABA-A receptor activity IEA --
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0005254 chloride channel activity IEA --
genes like me logo Genes that share ontologies with GABRG3: view

Phenotypes for GABRG3 Gene

GenomeRNAi human phenotypes for GABRG3:
genes like me logo Genes that share phenotypes with GABRG3: view

miRNA for GABRG3 Gene

miRTarBase miRNAs that target GABRG3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GABRG3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GABRG3 Gene

Localization for GABRG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GABRG3 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GABRG3 Gene COMPARTMENTS Subcellular localization image for GABRG3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GABRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0030054 cell junction IEA --
GO:0034707 chloride channel complex IEA --
genes like me logo Genes that share ontologies with GABRG3: view

Pathways for GABRG3 Gene

genes like me logo Genes that share pathways with GABRG3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for GABRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport --
GO:0007214 gamma-aminobutyric acid signaling pathway IEA --
GO:0007268 synaptic transmission TAS --
GO:0034220 ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with GABRG3: view

Compounds for GABRG3 Gene

(5) Tocris Compounds for GABRG3 Gene

Compound Action Cas Number
(-)-Bicuculline methiodide Water-soluble GABAA antagonist [40709-69-1]
(-)-Bicuculline methochloride Water-soluble GABAA antagonist [53552-05-9]
L-655,708 Selective for alpha5-containing GABAA receptors [130477-52-0]
Muscimol Potent GABAA agonist [2763-96-4]
SR 95531 hydrobromide Selective, competitive GABAA receptor antagonist [104104-50-9]

(2) ApexBio Compounds for GABRG3 Gene

Compound Action Cas Number
(+)-Bicuculline "GABAA receptor antagonist,competitve and classical" [485-49-4]
Bemegride [64-65-3]

(2) HMDB Compounds for GABRG3 Gene

Compound Synonyms Cas Number PubMed IDs
  • Cl2
Gamma-Aminobutyric acid
  • 3-Carboxypropylamine

(22) Drugbank Compounds for GABRG3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
37115-32-5 target potentiator
28981-97-7 target potentiator
  • 7-Bromo-5-(2-pyridyl)-3H-1,4-benzodiaxepin-2(1H)-one
1812-30-2 target potentiator
58-25-3 target potentiator
75696-02-5 target potentiator

(2) IUPHAR Ligand for GABRG3 Gene

Ligand Type Action Affinity Pubmed IDs
TBPS Channel blocker None
picrotoxin Channel blocker None

(1) Novoseek inferred chemical compound relationships for GABRG3 Gene

Compound -log(P) Hits PubMed IDs
gaba 44.2 1

(1) PharmGKB related drug/compound annotations for GABRG3 Gene

Drug/compound Annotation
antipsychotics CA
genes like me logo Genes that share compounds with GABRG3: view

Transcripts for GABRG3 Gene

mRNA/cDNA for GABRG3 Gene

(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(5) REFSEQ mRNAs :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GABRG3 Gene

Gamma-aminobutyric acid (GABA) A receptor, gamma 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GABRG3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GABRG3 Gene

No ASD Table

Relevant External Links for GABRG3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GABRG3 Gene

mRNA expression in normal human tissues for GABRG3 Gene

mRNA differential expression in normal tissues according to GTEx for GABRG3 Gene

This gene is overexpressed in Testis (8.0), Brain - Hypothalamus (6.5), and Pituitary (4.2).

Protein differential expression in normal tissues for GABRG3 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GABRG3 Gene

SOURCE GeneReport for Unigene cluster for GABRG3 Gene Hs.569475

genes like me logo Genes that share expressions with GABRG3: view

Expression partners for GABRG3 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GABRG3 Gene

Orthologs for GABRG3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GABRG3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GABRG3 35
  • 89.16 (n)
  • 94.84 (a)
(Canis familiaris)
Mammalia GABRG3 35
  • 92.22 (n)
  • 98.07 (a)
  • 98 (a)
(Mus musculus)
Mammalia Gabrg3 35
  • 88.15 (n)
  • 95.93 (a)
Gabrg3 16
Gabrg3 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Gabrg3 35
  • 88.08 (n)
  • 95.72 (a)
(Monodelphis domestica)
Mammalia GABRG3 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia GABRG3 36
  • 74 (a)
(Gallus gallus)
Aves GABRG3 35
  • 82.53 (n)
  • 92.54 (a)
  • 92 (a)
(Anolis carolinensis)
Reptilia GABRG3 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gabrg3 35
  • 78.77 (n)
  • 89.91 (a)
(Danio rerio)
Actinopterygii gabrg3 35
  • 76.18 (n)
  • 86.79 (a)
si:dkey-192o1.3 36
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8916 37
  • 40 (a)
Grd 37
  • 43 (a)
ort 37
  • 35 (a)
CG8916 36
  • 26 (a)
Grd 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea F09G2.5 37
  • 28 (a)
T15B7.16 37
  • 32 (a)
Y71D11A.5 37
  • 31 (a)
lgc-36 36
  • 24 (a)
lgc-37 36
  • 31 (a)
Species with no ortholog for GABRG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GABRG3 Gene

Gene Tree for GABRG3 (if available)
Gene Tree for GABRG3 (if available)

Paralogs for GABRG3 Gene

Paralogs for GABRG3 Gene

genes like me logo Genes that share paralogs with GABRG3: view

Variants for GABRG3 Gene

Sequence variations from dbSNP and Humsavar for GABRG3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs83100 -- 27,183,174(-) TGTCA(A/C)ACACT intron-variant
rs140670 -- 26,976,868(+) CGGGT(A/T)TTCAC intron-variant
rs140671 -- 26,976,951(+) TCTTC(C/G)TAGAG intron-variant
rs140672 -- 27,327,045(+) GCATC(A/G)ATCTT intron-variant
rs140673 -- 27,327,182(+) CATGC(A/C)ACATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GABRG3 Gene

Variant ID Type Subtype PubMed ID
esv2749487 CNV Deletion 23290073
esv2668795 CNV Deletion 23128226
nsv456734 CNV Loss 19166990
esv2663965 CNV Deletion 23128226
esv22505 CNV Loss 19812545
nsv437173 CNV Loss 16327808
nsv9203 CNV Gain 18304495
nsv827266 CNV Loss 20364138
nsv820788 CNV Deletion 20802225
esv24852 CNV Gain 19812545
esv2659305 CNV Deletion 23128226
nsv820165 CNV Gain 19587683
nsv438268 CNV Loss 16468122
nsv525863 CNV Gain 19592680
esv2676077 CNV Deletion 23128226
esv22196 CNV Loss 19812545
nsv524957 CNV Loss 19592680
esv2749489 CNV Deletion 23290073
esv4698 CNV Deletion 18987735
esv2749490 CNV Deletion 23290073
esv996941 CNV Deletion 20482838
esv1031890 CNV Deletion 17803354
esv2657489 CNV Deletion 23128226
nsv94466 CNV Loss 16902084
esv997057 CNV Loss 20482838
esv2657503 CNV Deletion 23128226
esv2634934 CNV Loss 19546169
esv2749491 CNV Deletion 23290073
esv2749492 CNV Deletion 23290073
esv2749493 CNV Deletion 23290073
esv2749494 CNV Deletion 23290073
nsv94798 CNV Insertion 16902084
nsv9204 CNV Loss 18304495
esv32599 CNV Gain 17666407
esv2573297 CNV Insertion 19546169
esv1147352 CNV Insertion 17803354
esv2749495 CNV Deletion 23290073
esv2079283 CNV Deletion 18987734
esv2749496 CNV Deletion 23290073
esv2659074 CNV Deletion 23128226
esv1041247 CNV Deletion 17803354
esv1762053 CNV Insertion 17803354
esv34176 CNV Loss 18971310
nsv832940 CNV Loss 17160897
nsv903730 CNV Gain 21882294
esv2749498 CNV Deletion 23290073
esv1006704 CNV Gain 20482838
esv2484353 CNV Insertion 19546169
esv270591 CNV Insertion 20981092
esv272631 CNV Insertion 20981092

Relevant External Links for GABRG3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GABRG3 Gene

Disorders for GABRG3 Gene

(2) University of Copenhagen DISEASES for GABRG3 Gene

Relevant External Links for GABRG3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GABRG3: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for GABRG3 Gene

Publications for GABRG3 Gene

  1. The gamma-aminobutyric acid receptor gamma 3 subunit gene (GABRG3) is tightly linked to the alpha 5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientation. (PMID: 7601451) Greger V. … Nakatsu Y. (Genomics 1995) 2 3 23
  2. Association of GABRG3 with alcohol dependence. (PMID: 14745296) Dick D.M. … Foroud T. (Alcohol. Clin. Exp. Res. 2004) 3 23 48
  3. Characterization of breakpoints in the GABRG3 and TSPY genes in a family with a t(Y;15)(p11.2;q12). (PMID: 14981720) Gole L. … Dennis N.R. (Am. J. Med. Genet. A 2004) 3 23
  4. Expression and pharmacology of human GABAA receptors containing gamma 3 subunits. (PMID: 8719414) Hadingham K.L. … Whiting P.J. (Eur. J. Pharmacol. 1995) 3 4
  5. Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. (PMID: 16080114) Ma D.Q. … Pericak-Vance M.A. (Am. J. Hum. Genet. 2005) 3 48

Products for GABRG3 Gene

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