 |
 | Services
| |
 |
Aliases & Descriptions for GABRG3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| GABA(A) receptor subunit gamma-3 3 | | gamma-aminobutyric acid (GABA) A receptor, gamma 3 2 | | gamma-aminobutyric acid A receptor, gamma 3 1 |
|
| | Search outside databases for aliases for GABRG3 genePrevious GC identifers: GC15P023369 GC15P020593 GC15P024651 GC15P024779 |
Summaries for GABRG3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: GBRG3_HUMAN, Q99928Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channelGene Wiki entry for GABRG3 |
Genomic Location for GABRG3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the GABRG3 gene 
Entrez Gene cytogenetic band: 15q12 Ensembl cytogenetic band: 15q12 HGNC cytogenetic band: 15q11-q13GABRG3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P024800:
(about GC identifiers)
Start:
|
24,799,263 bp from pter |
End:
|
25,451,622 bp from pter |
Size:
|
652,360 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000015.8 NT_010280.17 NT_078095.2
| Proteins for GABRG3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: GBRG3_HUMAN, Q99928 (See
protein sequence)Recommended Name: Gamma-aminobutyric acid receptor subunit gamma-3 precursor Size: 467 amino acids; 54289 Da
Subunit: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho
Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Miscellaneous: This subunit carries the benzodiazepine binding site
Secondary accessions: Q9HD46 Q9NYT2Post-translational modifications:
May be palmitoylated (By similarity)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_150092.2
ENSEMBL proteins: ENSP00000331912
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for GABRG3: Assays for GABRG3: | Protein
Domains/ Families for GABRG3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q99928
ProtoNet protein and cluster: Q99928 4 Blocks protein families: IPB005437 Gamma-aminobutyric-acid A receptor gamma subunit signature IPB005440 Gamma-aminobutyric-acid A receptor gamma 3 subunit signature IPB006028 Gamma-aminobutyric acid A (GABAA) receptor signature IPB006201 Neurotransmitter-gated ion-channel
UniProtKB/Swiss-Prot: GBRG3_HUMAN, Q99928Similarity: Belongs to the ligand-gated ionic channel (TC 1.A.9) family | Gene Function for GABRG3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_033223
Applied Biosystems Silencer® siRNAs for GABRG3
Sigma-Aldrich siRNA and siRNA Panels for GABRG3  Sigma-Aldrich shRNA for GABRG3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_033223                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_033223                                  untagged cDNA clones in CMV expression vector (see all 2): NM_033223 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_033223
UniProtKB/Swiss-Prot: GBRG3_HUMAN, Q99928Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channelGenatlas biochemistry entry for GABRG3:gamma-aminobutyric acid (GABA) A receptor,ionotropic,gamma 3,subunit,component of a pentameric receptor mediating inhibitory neurotransmission5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004890 | GABA-A receptor activity |
IEA | -- | | GO:0005216 | ion channel activity |
IEA | -- | | GO:0005230 | extracellular ligand-gated ion channel activity |
NAS | -- | | GO:0005254 | chloride channel activity |
IEA | -- | | GO:0030594 | neurotransmitter receptor activity |
IEA | -- | About this table | Pathways & Interactions for GABRG3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Sigma-Aldrich "Your Favorite Gene" Pathway for GABRG3 (Your Favorite Gene powered by Ingenuity) 
5/20 Interacting proteins for GABRG3 (ENSP000003319123) via UniProtKB, MINT, and/or STRING (see all 20
)About this table
4 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006811 | ion transport |
IEA | -- | | GO:0006821 | chloride transport |
IEA | -- | | GO:0007214 | gamma-aminobutyric acid signaling pathway |
IEA | -- | | GO:0007268 | synaptic transmission |
NAS | -- | About this table
|
Drugs & Compounds for GABRG3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for GABRG3 |
 | Sigma-Aldrich Small Molecules for GABRG3: Inhibitor |
Compounds for GABRG3 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| Muscimol | Potent GABAA agonist | [2763-96-4] | | (+)-Bicuculline | Potent GABAA antagonist | [485-49-4] | | Indiplon | Subtype-selective GABAA receptor positive allosteric modulator | [325715-02-4] | | L-655,708 | Selective for alpha5-containing GABAA receptors | [130477-52-0] | | SR 95531 hydrobromide | Selective, competitive GABAA receptor antagonist | [104104-50-9] | About this table
|
Transcripts for GABRG3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_033223
Sigma-Aldrich siRNA and siRNA Panels for GABRG3  Sigma-Aldrich shRNA for GABRG3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_033223 REFSEQ mRNAs for GABRG3 gene: NM_033223.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_033223               OriGene GFP tagged cDNA clone in CMV expression vector: NM_033223                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_033223                                  untagged cDNA clones in CMV expression vector (see all 2): NM_033223  Additional cDNA sequence: BC029850.1 S82769.1 2 DOTS entries: DT.100742755 DT.91656723 3 AceView cDNA sequences:S82769 NM_033223 BI461645
highest scoring ESTs for GABRG3:S82769 BC029850 NM_033223 BI546934 BI818830 BX282033 BC045709 BG201662 BG203253 BI461645 Unigene Cluster for GABRG3: Gamma-aminobutyric acid (GABA) A receptor, gamma 3 Hs.569475 [show with all ESTs]Unigene Representative Sequence: BC029850
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000333743
|
Expression for GABRG3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| GABRG3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for GABRG3
1 / 2 / 3 4 probe-sets matching GABRG3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CCGGTTTAAA
SOURCE GeneReport for Unigene cluster: Hs.569475
Expression variation in blood from EXPOLDB for GABRG3 |
Orthologs for GABRG3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GABRG3 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for GABRG3
ENSEMBL Gene Tree for GABRG3 | Paralogs for GABRG3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for GABRG3 gene
- GABRG22 GABRE2 GABRG12
|
SNPs/Variants for GABRG3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for GABRG3 (up to first 250kb)
|
Disorders & Mutations for GABRG3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 600233
Genetic Association Database: GABRG3 Human Genome Epidemiology Navigator: GABRG3 (7 documents)
|
Medical News for GABRG3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for GABRG3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/18 PubMed articles for GABRG3 gene (see all 18
): |
Search for GABRG3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing GABRG3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing GABRG3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GABRG3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| Protein Spotlight | http://www.expasy.org/spotlight/back_issues/sptlt056.shtml |
|
| | | About This Section
| --
| Services for GABRG3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for GABRG3:

|
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|