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Aliases & Descriptions for GABRG1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DKFZp686H2042 2 | | MGC33838 2 |
| | | Descriptions |
|---|
| GABA(A) receptor subunit gamma-1 3 | | gamma-1 polypeptide 2 | | gamma-aminobutyric acid (GABA) A receptor, gamma 1 2 | | gamma-aminobutyric acid A receptor, gamma 1 2 |
|
| | Search outside databases for aliases for GABRG1 genePrevious GC identifers: GC04U990020 GC04M045892 GC04M045957 GC04M045953 GC04M045878 |
Summaries for GABRG1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for GABRG1: The protein encoded by this gene belongs to the ligand-gated ionic channel family. It is an integral membrane protein and plays an important role in inhibiting neurotransmission by binding to the benzodiazepine receptor and opening an integral chloride channel. This gene is clustered with three other family members on chromosome 4. [provided by RefSeq] UniProtKB/Swiss-Prot: GBRG1_HUMAN, Q8N1C3Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel |
Genomic Location for GABRG1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the GABRG1 gene 
Entrez Gene cytogenetic band: 4p12 Ensembl cytogenetic band: 4p12 HGNC cytogenetic band: 4p12GABRG1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M045732:
(about GC identifiers)
Start:
|
45,732,543 bp from pter |
End:
|
45,820,839 bp from pter |
Size:
|
88,297 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000004.10 NT_006238.10
| Proteins for GABRG1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: GBRG1_HUMAN, Q8N1C3 (See
protein sequence)Recommended Name: Gamma-aminobutyric acid receptor subunit gamma-1 precursor Size: 465 amino acids; 53595 Da
Subunit: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho
Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Miscellaneous: This subunit carries the benzodiazepine binding site
Secondary accessions: Q5H9T8Post-translational modifications:
May be palmitoylated (By similarity)1
REFSEQ proteins: NP_775807.2
ENSEMBL proteins: ENSP00000295452
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for GABRG1: Assays for GABRG1: | Protein
Domains/ Families for GABRG1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8N1C3
ProtoNet protein and cluster: Q8N1C3 4 Blocks protein families: IPB005437 Gamma-aminobutyric-acid A receptor gamma subunit signature IPB005438 Gamma-aminobutyric-acid A receptor gamma 1 subunit signature IPB006028 Gamma-aminobutyric acid A (GABAA) receptor signature IPB006201 Neurotransmitter-gated ion-channel
UniProtKB/Swiss-Prot: GBRG1_HUMAN, Q8N1C3Similarity: Belongs to the ligand-gated ionic channel (TC 1.A.9) family | Gene Function for GABRG1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_173536
Applied Biosystems Silencer® siRNAs for GABRG1
Sigma-Aldrich siRNA and siRNA Panels for GABRG1  Browse shRNA at Sigma-Aldrich  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_173536                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_173536                                  untagged cDNA clone in CMV expression vector: NM_173536 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_173536
UniProtKB/Swiss-Prot: GBRG1_HUMAN, Q8N1C3Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channelGenatlas biochemistry entry for GABRG1:gamma-aminobutyric acid (GABA) A receptor,ionotropic,gamma 1,subunit,component of a pentameric receptor mediating inhibitory neurotransmission5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004890 | GABA-A receptor activity |
IEA | -- | | GO:0005216 | ion channel activity |
IEA | -- | | GO:0005230 | extracellular ligand-gated ion channel activity |
IEA | -- | | GO:0005254 | chloride channel activity |
IEA | -- | | GO:0030594 | neurotransmitter receptor activity |
IEA | -- | About this table | Pathways & Interactions for GABRG1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Sigma-Aldrich "Your Favorite Gene" Pathway for GABRG1 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for GABRG1 
5/18 Interacting proteins for GABRG1 (ENSP000002954523) via UniProtKB, MINT, and/or STRING (see all 18
)About this table
4 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006811 | ion transport |
IEA | -- | | GO:0006821 | chloride transport |
IEA | -- | | GO:0007214 | gamma-aminobutyric acid signaling pathway |
IEA | -- | | GO:0007268 | synaptic transmission |
IEA | -- | About this table
|
Drugs & Compounds for GABRG1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for GABRG1 |
 | Sigma-Aldrich Small Molecules for GABRG1: Inhibitor |
Compounds for GABRG1 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| Muscimol | Potent GABAA agonist | [2763-96-4] | | (+)-Bicuculline | Potent GABAA antagonist | [485-49-4] | | Indiplon | Subtype-selective GABAA receptor positive allosteric modulator | [325715-02-4] | | L-655,708 | Selective for alpha5-containing GABAA receptors | [130477-52-0] | | SR 95531 hydrobromide | Selective, competitive GABAA receptor antagonist | [104104-50-9] | About this table
|
Transcripts for GABRG1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_173536
Sigma-Aldrich siRNA and siRNA Panels for GABRG1  Browse shRNA at Sigma-Aldrich  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_173536 REFSEQ mRNAs for GABRG1 gene: NM_173536.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_173536               OriGene GFP tagged cDNA clone in CMV expression vector: NM_173536                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_173536                                  untagged cDNA clone in CMV expression vector: NM_173536  Additional cDNA sequence: AK122845.1 AK124800.1 AK289806.1 AK299884.1 BC031087.1 BX648937.1 CR933628.1 1 DOTS entry: DT.75165789 18 AceView cDNA sequences:F09193 NM_173536 AK124800 BQ188415 CK299610 AK122845 BI600401 CK005243 BX648937 BC031087 BX420702 F11531 N92667 AL119089 BX410065 AL119176 T23444 N99613
highest scoring ESTs for GABRG1:AK122845 BC031087 BI600401 BX648937 N92667 AK124800 AL119089 AL119176 BQ188415 BX420702 Unigene Cluster for GABRG1: Gamma-aminobutyric acid (GABA) A receptor, gamma 1 Hs.375051 [show with all ESTs]Unigene Representative Sequence: BX648937
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000295452
|
Expression for GABRG1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| GABRG1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for GABRG1
1 / 2 / 3 4 probe-sets matching GABRG1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.375051
|
Orthologs for GABRG1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GABRG1 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for GABRG1
ENSEMBL Gene Tree for GABRG1 | Paralogs for GABRG1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for GABRG1 gene
- GABRG22 GABRE2 GABRG32
|
SNPs/Variants for GABRG1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for GABRG1 (up to first 250kb)
|
Disorders & Mutations for GABRG1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 137166
Genetic Association Database: GABRG1 Human Genome Epidemiology Navigator: GABRG1 (6 documents)
|
Medical News for GABRG1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for GABRG1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/16 PubMed articles for GABRG1 gene (see all 16
): |
Search for GABRG1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing GABRG1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing GABRG1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GABRG1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| Protein Spotlight | http://www.expasy.org/spotlight/back_issues/sptlt056.shtml |
|
| | | About This Section
| --
| Services for GABRG1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for GABRG1:

|
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|