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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GABRE Gene

protein-coding GIFtS: 57
GCID: GC0XM151121

gamma-aminobutyric acid (GABA) A receptor, epsilon

Explore 9 diseases affiliated with
GABRE via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Gamma-Aminobutyric Acid (GABA) A Receptor, Epsilon¹ ²
GABA(A) Receptor Subunit Epsilon² ³
GABA(A) Receptor, Epsilon²
Gamma-Aminobutyric Acid Receptor Subunit Epsilon²

External Ids:	HGNC: 4085¹	Entrez Gene: 2564²	Ensembl: ENSG00000102287⁷	OMIM: 300093⁵	UniProtKB: P78334³

Export aliases for GABRE gene to outside databases

Previous GC identifers: GC0XM145456 GC0XM147779 GC0XM148869 GC0XM149739 GC0XM150792 GC0XM150873 GC0XM139977

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GABRE:

The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric

acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic

transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a

cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced

transcript variants have been identified, but only one is thought to encode a protein. (provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: GBRE_HUMAN, P78334

Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding

to the GABA/benzodiazepine receptor and opening an integral chloride channel

summary for GABRE:

GABAA receptors are members of the cys-loop family of ligand-gated ion channels, responsible for mediating

the inhibitory effects of GABA alongside GABAB and GABAC receptors. They are pentameric proteins, consisting

of 5 subunits belonging to different families (alpha1-6, beta1-3, gamma1-3, delta, pi, epsilon, rho, theta).

The most abundant GABAA receptor in the mammalian brain consist of two copies each of alpha1 and beta2 with

a single gamma2 subunits. GABAA receptors contain an integral chloride channel, and have modulatory sites

for benzodiazepines, barbiturates, neurosteroids and ethanol.

Gene Wiki entry for GABRE

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_167198.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GABRE gene promoter:
CREB AREB6 deltaCREB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GABRE promoter sequence

Search SABiosciences Chromatin IP Primers for GABRE

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GABRE

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28

GABRE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GABRE gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM151121: view genomic region (about GC identifiers)

Start:	151,121,596 bp from pter	End:	151,143,152 bp from pter
Size:	21,557 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GBRE_HUMAN, P78334 (See protein sequence)

Recommended Name: Gamma-aminobutyric acid receptor subunit epsilon precursor

Size: 506 amino acids; 57972 Da

Subunit: Generally pentameric. Associates with alpha and beta subunits

Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane;

Multi-pass membrane protein

Secondary accessions: O15345 O15346 Q99520

Explore the universe of human proteins at neXtProt for GABRE: NX_P78334

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P78334

GABRE Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004952.2

ENSEMBL proteins:

ENSP00000359353 ENSP00000359350 ENSP00000389384 ENSP00000398555 ENSP00000397335

ENSP00000377491

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Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	--	--
GO:0005887	integral to plasma membrane	TAS	9039914
GO:0016021	integral to membrane	--	--
GO:0030054	cell junction	IEA	--
GO:0034707	chloride channel complex	IEA	--

GABRE for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GABRE for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR018000 Neurotransmitter_ion_chnl_CS

IPR006028 GABAA_rcpt

IPR006201 Neur_channel

IPR008099 GABAAe_rcpt

IPR006202 Neur_chan_lig-bd

Graphical View of Domain Structure for InterPro Entry P78334

ProtoNet protein and cluster: P78334

3 Blocks protein families:

IPB006028 Gamma-aminobutyric acid A (GABAA) receptor signature

IPB006201 Neurotransmitter-gated ion-channel

IPB008099 Gamma-aminobutyric-acid A receptor epsilon subunit signature

UniProtKB/Swiss-Prot: GBRE_HUMAN, P78334

Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5)

subfamily. GABRE sub-subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: GBRE_HUMAN, P78334

Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding

to the GABA/benzodiazepine receptor and opening an integral chloride channel

Genatlas biochemistry entry for GABRE:

gamma-aminobutyric acid (GABA) A receptor,ionotropic,epsilon,predominantly expressed in adult brain,subunit,component

of a pentameric receptor mediating inhibitory neurotransmission,clustered with GABRA3 and GABRB4

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	--	--
GO:0004890	GABA-A receptor activity	IEA	--
GO:0005230	extracellular ligand-gated ion channel activity	IEA	--
GO:0005254	chloride channel activity	IEA	--

GABRE for ontologies About GeneDecksing

Animal Models:

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		hsa-miR-485-5p hsa-miR-623 hsa-miR-875-3p hsa-miR-513a-5p hsa-miR-15a hsa-miR-2110 hsa-miR-4260 hsa-miR-1304

		SwitchGear 3'UTR luciferase reporter plasmid: GABRE 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABRE

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Akt Signaling

Akt Signaling

1.00

Apoptosis Pathway

Akt Pathway

0.39

Class A/1 (Rhodopsin-like receptors)

Neuroactive ligand-receptor interaction

0.38

Sweet Taste Signaling

Sperm Motility

0.36

GABA A receptor activation

GABA signaling in brain

0.26

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for GABRE

GABA signaling in brain

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GABRE

	Sperm Motility
	Akt Signaling

1 Tocris Bioscience Pathway for GABRE

Akt Pathway

1 Kegg Pathway (Kegg details for GABRE):

Neuroactive ligand-receptor interaction

GABRE for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GABRE

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	TAS	9039914
GO:0006811	ion transport	--	--
GO:0006821	chloride transport	--	--
GO:0007214	gamma-aminobutyric acid signaling pathway	TAS	9039914

GABRE for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for GABRE available from Tocris Bioscience About this table

Compound	Action	CAS #
Muscimol	Potent GABAA agonist	[2763-96-4]
(+)-Bicuculline	Potent GABAA antagonist	[485-49-4]
Indiplon	Subtype-selective GABAA receptor positive allosteric modulator	[325715-02-4]
L-655,708	Selective for alpha5-containing GABAA receptors	[130477-52-0]
SR 95531 hydrobromide	Selective, competitive GABAA receptor antagonist	[104104-50-9]

2 HMDB Compounds for GABRE About this table

Compound	Synonyms	CAS #	PubMed Ids
Chlorine	Cl2 (see all 13)	16887-00-6	--
Gamma-Aminobutyric acid	3-Carboxypropylamine (see all 27)	56-12-2	--

10/23 DrugBank Compounds for GABRE (see all 23) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Lorazepam	(+/-)-Lorazepam (see all 3)	846-49-1	target	potentiator	20138190 18384456 11752090
Adinazolam	--	37115-32-5	target	potentiator	6320036 6148400
Chlordiazepoxide	--	58-25-3	target	potentiator	18384456 11752090
Clobazam	--	22316-47-8	target	potentiator	18384456 11752090
Clonazepam	Chlonazepam (see all 2)	1622-61-3	target	potentiator	18384456 11752090
Clorazepate	--	23887-31-2	target	potentiator	18384456 11752090
Diazepam	--	439-14-5	target	potentiator	18384456 11752090
Estazolam	--	29975-16-4	target	potentiator	639854 2889803
Flurazepam	--	17617-23-1	target	potentiator	18384456 11752090
Halazepam	--	23092-17-3	target	potentiator	2867566 6738302

Search CenterWatch for drugs/clinical trials and news about GABRE / GBRE

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GABRE gene (4 alternative transcripts):

NM_004961.3 NM_021984.2 NM_021987.2 NM_021990.2

Unigene Cluster for GABRE:

Gamma-aminobutyric acid (GABA) A receptor, epsilon

Hs.22785 [show with all ESTs]

Unigene Representative Sequence: BC026337

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000370328(uc004ffi.3 uc011myd.2) ENST00000370325 ENST00000486255

ENST00000483564 ENST00000495862 ENST00000489333 ENST00000462018 ENST00000441219(uc011mye.1)

ENST00000476016 ENST00000425556 ENST00000474932 ENST00000465405 ENST00000491339

ENST00000417300 ENST00000393914

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		8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate GABRE (see all 31):
		hsa-miR-485-5p hsa-miR-623 hsa-miR-875-3p hsa-miR-513a-5p hsa-miR-15a hsa-miR-2110 hsa-miR-4260 hsa-miR-1304

		SwitchGear 3'UTR luciferase reporter plasmid: GABRE 3' UTR sequence

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Additional cDNA sequence:

AF086385.1 AK299174.1 AK303072.1 BC026337.1 BC047108.1 BC059376.1 U66661.1 Y07637.1

Y09765.1

11 DOTS entries:

DT.443863 DT.91825239 DT.100816070 DT.91755826 DT.95350380 DT.97833425 DT.115945 DT.95107482

DT.91755827 DT.121289670 DT.91750087

24/125 AceView cDNA sequences (see all 125):

NM_021987 U66661 AI824213 AI963395 AA954089 BM678523 AI682740 Y09765

BX478724 NM_021984 C00867 AI334197 AI400573 CA310783 AA321214 CR591394

CD671953 AA855126 AI432632 CA449311 AI334196 AA677292 AA347289 AW316736

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for GABRE (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12a	·	12b	^	13a	·	13b	·	13c	^	14a	·	14b
SP1:							-		-		-				-		-												-		-		-		-										-
SP2:							-				-				-		-
SP3:																									-				-
SP4:																																													-
SP5:																																			-

ECgene alternative splicing isoforms for GABRE

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GABRE expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCCAATGCT

About this image

GABRE expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See GABRE Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GABRE

SOURCE GeneReport for Unigene cluster: Hs.22785

UniProtKB/Swiss-Prot: GBRE_HUMAN, P78334

Tissue specificity: Expressed in many tissues. Highest levels of expression in adult heart and placenta

SABiosciences Expression via Pathway-Focused PCR Arrays including GABRE:

Neurotransmitter Receptors in human mouse rat

GABA & Glutamate in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GABRE

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABRE

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for GABRE gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F1NES8_CHICK⁶	GABA A receptor	49(a)	1 ↔ 1	4(10924256-10951624)
lizard (Anolis carolinensis)	Reptilia	--	--	46(a)	1 ↔ 1	GL343376.1(989553-999807)
fruit fly (Drosophila melanogaster)	Insecta	CG12344⁶ CG8916⁶ (see all 6)	--	22(a) 21(a) (see all 6)	possible ortholog many ↔ many (see all 6)	2R(6714934-6721741) X(15815988-15818591)
worm (Caenorhabditis elegans)	Secernentea	F55D10.5³	Ligand-gated ionic channel	31(a) (best of 3)		X(4758292-4763557) --

ENSEMBL Gene Tree for GABRE (if available)
TreeFam Gene Tree for GABRE (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GABRE gene

GABRG2² GABRA2² GABRA6² GABRA4² GABRG1² GABRG3² GABRA5² GABRA3²

GABRA1²

18/23 SIMAP similar genes for GABRE using alignment to 6 protein entries: GBRE_HUMAN (see all proteins) (see all similar genes):

GABRG3 GABRG1 GABRG2 GABRA1 GABRA4 GABRA6

GABRA5 GABRA3 GABRA2 GLRA3 GABRB1 GABRB2

DKFZp781L0846 GABRB3 GABRD GLRA1 GLRA4 GABRR1

GABRE for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143741224^1,2		--	151121242(+)	`TGTGCC/TTCAGA`	1	--	ds500¹		0	--	--	--	--
rs148140429^1,2		--	151121313(+)	`GTCTCA/GTTCTG`	1	--	ds500¹		0	--	--	--	--
rs7054391^1,2	C,F,H	--	151121446(+)	`TTCCTT/CACTAA`	1	--	ds500¹		12		NS EA NA WA CSA	941
rs5924704^1,2	C	--	151121448(+)	`CCTTAC/TTAATG`	1	--	ds500¹		2		NA	4
rs147329678^1,2		--	151121683(+)	`CCCCCA/CAACAA`	1	--	ut3¹		0	--	--	--	--
rs138642850^1,2		--	151121814(+)	`AGAAAC/TTGAGC`	1	--	ut3¹		0	--	--	--	--
rs142713506^1,2		--	151121899(+)	`GAGCTA/GTCTAG`	1	--	ut3¹		0	--	--	--	--
rs147377871^1,2		--	151122134(+)	`ATTGAC/TTGTGA`	1	--	ut3¹		0	--	--	--	--
rs5970170^1,2	C,F,H	--	151122248(+)	`GCGAGT/CAATGC`	1	--	ut3¹ ese³		18		NS EA NA	2212
rs111864400^1,2	C	--	151122277(+)	`TCCTTA/GGTTTC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GABRE (151121596 - 151143152 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GABRE: --
Locus Specific Mutation Databases (LSDB): GABRE

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GABRE for disorders           About GeneDecksing

OMIM gene information: 300093    OMIM disorders: --

9 diseases for GABRE:    About MalaCards

lobular neoplasia febrile seizures essential tremor anorexia nervosa

tremor migraine bipolar disorder seizures

neuronitis

Human Genome Epidemiology (HuGE) Navigator: GABRE (9 documents)

Export disorders for GABRE gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GABRE gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with GABRE)

Utopia: connect your pdf to the dynamic
world of online information

Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit. (PubMed id 9039914)^{1, 2, 3} Davies P.A.... Kirkness E.F. (1997)
An mRNA encoding a putative GABA-gated chloride channel is expressed in the human cardiac conduction system. (PubMed id 9084408)^{1, 2, 3} Garret M.... Margolskee R.F. (1997)
A gene in human chromosome band Xq28 (GABRE) defines a putative new subunit class of the GABAA neurotransmitter receptor. (PubMed id 9339354)^{1, 2} Wilke K.... Poustka A. (1997)
Investigation of gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility. (PubMed id 19087248)^{1, 9} Fernandez F....Griffiths L.R. (2008)
Gamma-aminobutyric acid GABRA4, GABRE, and GABRQ rece ptor polymorphisms and risk for essential tremor. (PubMed id 21422964)¹ GarcA-a-MartA-n E....JimAcnez-JimAcnez F.J. (2011)
Atypical behavioural effects of lorazepam: clues to t he design of novel therapies? (PubMed id 20138190)⁷ Giersch A....Vidailhet P. (2010)
Developmental co-regulation of the beta and gamma GAB AA receptor subunits with distinct alpha subunits in the human dorsolateral pre frontal cortex. (PubMed id 20609421)¹ Fillman S.G....Weickert C.S. (2010)
Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)¹ Pinheiro A.P....Woodside D.B. (2010)
Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)¹ Tabakoff B....Hoffman P.L. (2009)
Benzodiazepines in epilepsy: pharmacology and pharmac okinetics. (PubMed id 18384456)⁷ Riss J....Collins S. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2564	HGNC: 4085	AceView: GABRE	Ensembl:ENSG00000102287	euGenes: HUgn2564
ECgene: GABRE	Kegg: 2564	H-InvDB: GABRE

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GABRE	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GABRE gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GABRE gene:
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GeneCards and IP:
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gamma-aminobutyric acid (GABA) A receptor, epsilon

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gamma-aminobutyric acid (GABA) A receptor, epsilon

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