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GABRB2 Gene

protein-coding GIFtS: 68

GC05M160653

gamma-aminobutyric acid (GABA) A receptor, beta 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC119386 ^²
MGC119388 ^²
MGC119389 ^²
OTTHUMP00000160872 ^²

Descriptions
GABA(A) receptor subunit beta-2 ^³
gamma-aminobutyric acid (GABA) A receptor, beta 2 ^²
gamma-aminobutyric acid A receptor, beta 2 ^¹

External Ids
HGNC: 4082¹
Entrez Gene: 2561²
UniProtKB: P47870³
Ensembl: ENSG00000145864⁷

Search outside databases for aliases for GABRB2 gene

Previous GC identifers: GC05M160838 GC05M161228 GC05M160656 GC05M160701

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GABRB2:

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the

fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A

receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding

alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2

transcript variants, differing by a 114 bp insertion. [provided by RefSeq]

UniProtKB/Swiss-Prot: GBRB2_HUMAN, P47870

Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal

inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

Gene Wiki entry for GABRB2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GABRB2 gene

Entrez Gene cytogenetic band: 5q34 Ensembl cytogenetic band: 5q34 HGNC cytogenetic band: 5q34

GABRB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M160653: (about GC identifiers)

Start:	160,648,014 bp from pter
End:	160,907,708 bp from pter
Size:	259,695 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.8 NT_023133.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GBRB2_HUMAN, P47870 (See protein sequence)

Recommended Name: Gamma-aminobutyric acid receptor subunit beta-2 precursor

Size: 474 amino acids; 54606 Da

Subunit: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma,

delta, and rho. Binds UBQLN1

Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane

protein. Cell membrane; Multi-pass membrane protein

Secondary accessions: Q16323 Q4FZB2

Alternative splicing: 2 isoforms: P47870-1 P47870-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_000804.1 NP_068711.1

ENSEMBL proteins:

ENSP00000274546 ENSP00000274547 ENSP00000377531

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich AQUA Peptides for GABRB2
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GABA A Receptor beta 2 + 3, GABA A Receptor beta 2)
	Human Recombinant Proteins from Abnova (GABRB2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	8264558
GO:0030054	cell junction	IEA	--
GO:0045202	synapse	IEA	--
GO:0045211	postsynaptic membrane	IEA	--

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Antibodies for GABRB2:

	Invitrogen Antibodies for GABRB2
	Millipore Mono- and Polyclonal Antibodies for the study of GABRB2
	Sigma-Aldrich Antibodies for GABRB2
	R&D Systems Antibodies for GABRB2 (GABA-A-R beta 2)
	Antibodies from Abcam (GABA A Receptor beta 2 + 3, GABA A Receptor beta 2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for GABRB2

Assays for GABRB2:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of GABRB2
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P47870

ProtoNet protein and cluster: P47870

3 Blocks protein families:

IPB002289 Gamma-aminobutyric-acid A receptor beta subunit signature

IPB006028 Gamma-aminobutyric acid A (GABAA) receptor signature

IPB006201 Neurotransmitter-gated ion-channel

UniProtKB/Swiss-Prot: GBRB2_HUMAN, P47870

Similarity: Belongs to the ligand-gated ionic channel (TC 1.A.9) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GABRB2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GABRB2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000813

Applied Biosystems Silencer® siRNAs for GABRB2

Sigma-Aldrich siRNA and siRNA Panels for GABRB2

Sigma-Aldrich shRNA for GABRB2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GABRB2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000813
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000813
untagged cDNA clones in CMV expression vector (see all 2): NM_000813

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_021911

UniProtKB/Swiss-Prot: GBRB2_HUMAN, P47870

Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal

inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

Genatlas biochemistry entry for GABRB2:

gamma-aminobutyric acid (GABA) A receptor,ionotropic,beta 2,subunit,component of a pentameric

receptor mediating inhibitory neurotransmission

5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Gabrb2):

behavior/neurological

hearing/vestibular/ear

homeostasis/metabolism

nervous system

no phenotypic analysis

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004890	GABA-A receptor activity	TAS	8264558
GO:0005216	ion channel activity	IEA	--
GO:0005230	extracellular ligand-gated ion channel activity	IEA	--
GO:0005254	chloride channel activity	IEA	--
GO:0030594	neurotransmitter receptor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for GABRB2 (Your Favorite Gene powered by Ingenuity)

GABA Receptor Signaling

GeneDecks GABRB2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for GABRB2

5/20 Interacting proteins for GABRB2 (P47870² ENSP00000274547³) via UniProtKB, MINT, and/or STRING (see all 20 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRAK2	ENSP00000328875³	STRING (score=.891)
GABRA6	ENSP00000274545³	STRING (score=.826)
GABRG1	ENSP00000295452³	STRING (score=.826)
GABRG2	ENSP00000349000³	STRING (score=.825)
GABRA1	ENSP00000023897³	STRING (score=.824)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0007214	gamma-aminobutyric acid signaling pathway	TAS	8264558
GO:0007268	synaptic transmission	TAS	8264558

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for GABRB2

Sigma-Aldrich Small Molecules for GABRB2:

Antagonist Allosteric Modulator Agonist Inhibitor Ligand

Compounds for GABRB2 available from Tocris Bioscience

Compound	Action	CAS number
Muscimol	Potent GABAA agonist	[2763-96-4]
(+)-Bicuculline	Potent GABAA antagonist	[485-49-4]
Indiplon	Subtype-selective GABAA receptor positive allosteric modulator	[325715-02-4]
L-655,708	Selective for alpha5-containing GABAA receptors	[130477-52-0]
SR 95531 hydrobromide	Selective, competitive GABAA receptor antagonist	[104104-50-9]

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GABRB2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GABRB2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000813

Sigma-Aldrich siRNA and siRNA Panels for GABRB2

Sigma-Aldrich shRNA for GABRB2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000813 NM_021911

REFSEQ mRNAs for GABRB2 gene (2 alternative transcripts):

NM_000813.2 NM_021911.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000813 NM_021911

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000813
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000813
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000813

Additional cDNA sequence:

AK055125.1 AK289730.1 AK289815.1 AK294437.1 AK297609.1 BC036592.2 BC099705.1 BC099719.1

BC105639.1 CR621869.1 S67368.1 S77553.1 S77554.1

5 DOTS entries:

DT.92416980 DT.206062 DT.102823025 DT.100746805 DT.120819183

16 AceView cDNA sequences:

AL118953 CR621869 BX341215 S77553 NM_021911 BX341214 NM_000813 S77554

BX327475 BE697211 S67368 BX493652 BE697247 CD609593 CD609591 CD609589

highest scoring ESTs for GABRB2:

S67368 AL118953 BC099705 BC099719 BE697247 BX327475 BX341214 BX341215 CR621869 NM_000813

Unigene Cluster for GABRB2:

Gamma-aminobutyric acid (GABA) A receptor, beta 2

Hs.303527 [show with all ESTs]

Unigene Representative Sequence: NM_021911

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for GABRB2

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	·	14c
SP1:					-																				-
SP2:																									-
SP3:
SP4:					-						-
SP5:			-

About this scheme

ECgene alternative splicing isoforms for GABRB2

3 Ensembl transcripts including schematic representations:

ENST00000353437 ENST00000274547 ENST00000393959

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GABRB2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GABRB2

¹ / ² / ³

7 probe-sets matching GABRB2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
47722_at²^{, 3}	U95-B	1	1.00	1.00	0.97	0.84	R40170	0.20	1.00	0.72	1
32460_at²^{, 3}	U95-A	2	1.00	0.97	0.42	1.21	S67368	1.00	1.00	1.00	1
242344_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
207352_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_021911	0.60	1.00	0.82	1
1557122_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
242344_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207352_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks GABRB2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.303527
Expression variation in blood from EXPOLDB for GABRB2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GABRB2 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GABRB2¹	--	gamma-aminobutyric acid (GABA) A receptor, beta 2	90.18(n) 94.11(a)	489146 XM_862009.1 XP_867102.1
chimpanzee (Pan troglodytes)	GABRB2¹	--	gamma-aminobutyric acid (GABA) A receptor, beta 2	99.93(n) 100(a)	462240 XM_001143894.1 XP_001143894.1
cow (Bos taurus)	GABRB2¹	--	gamma-aminobutyric acid (GABA) A receptor, beta 2	92.19(n) 97.46(a)	540657 XM_612515.3 XP_612515.3
rat (Rattus norvegicus)	Gabrb2¹	--	gamma-aminobutyric acid (GABA) A receptor, beta 2	91.21(n) 99.79(a)	25451 NM_012957.1 NP_037089.1
mouse (Mus musculus)	Gabrb2^{1, 5}	11 (28.60 cM)⁵	gamma-aminobutyric acid (GABA) A receptor, subunit more⁵ gamma-aminobutyric acid (GABA-A) receptor, subunit more¹	91.28(n)¹ 99.79(a)¹	14401¹ NM_008070.3¹ NP_032096.1¹ AF529170⁵ AF529171⁵ (see all 20)

About this table Species with no ortholog for GABRB2

ENSEMBL Gene Tree for GABRB2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GABRB2 gene

GABRB3² GABRB1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1169 NCBI SNPs in GABRB2 are shown (see all 1169 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 453)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1096^1,2	A,C,F,H,O	160649163(+)	`TTACTG/ATTTGA`	2	--	ut3¹		8	MN NA EU EA WA	726
	rs252947^1,2	A,C,F,H,O	160648456(+)	`GTGAGG/ATTTAA`	2	--	ut3¹		7	NA EU EA WA	528
	rs592403^1,2	A,C,F,H	160652562(-)	`TTTCTG/TAATTT`	2	--	ut3¹		7	NA EA MN EU WA	588
	rs12523641^1,2	A,C,F,H	160651822(+)	`ACAAGG/AAATCA`	2	--	ut3¹		7	NA EU EA WA	556
	rs168697^1,2	A,C,F,H	160650709(+)	`CTAGCA/GGTCAT`	2	--	ut3¹		4	EU EA WA	418
	rs13171815^1,2	C,F,H	160908842(+)	`ACATAG/CTGCTG`	2	--	ng3¹		7	NA EU EA WA	546
	rs1644439^1,2	C,F,H	160651730(+)	`TGAAGG/AATAAA`	2	--	ut3¹		4	EU EA WA	416
	rs13177547^1,2	C,F,H	160652014(+)	`CAAAAT/CATGAG`	2	--	ut3¹		4	EU EA WA	392
	rs10067495^1,2	C,F,H	160909332(+)	`GTGTAG/AGTTGA`	2	--	ng3¹		4	EU EA WA	416
	rs3816596^1,2	C,F,H	160907910(+)	`CGAGTC/TTGGGG`	2	--	ng3¹		4	EU EA WA	420

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HapMap Linkage Disequilibrium images for GABRB2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600232

Genetic Association Database: GABRB2
Human Genome Epidemiology Navigator: GABRB2 (19 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/49 PubMed articles for GABRB2 gene (see all 49 ):

Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia. (PubMed id 16172613)^{3, 6} Petryshen T.L....Sklar P. (2005)
Association studies of neurotransmitter gene polymorphisms in alcoholic Caucasians. (PubMed id 15542698)^{3, 6} Foley P.F....Dodd P.R. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Association of the gamma-aminobutyric acid A receptor gene cluster with alcohol dependence in Taiwanese Han. (PubMed id 12232773)^{3, 6} Chang Y.T....Cheng A.T. (2002)
Association analysis of GABAAbeta2 and gamma2 gene polymorphisms with event-related prefrontal activity in man. (PubMed id 11140951)^{3, 6} Winterer G....Sander T. (2000)
Cloning, sequence analysis and expression of two forms of mRNA coding for the human beta 2 subunit of the GABAA receptor. (PubMed id 7707873)^{3, 4} McKinley D.D.... Carter D.B. (1995)
Mapping of the beta 2 subunit gene (GABRB2) to microdissected human chromosome 5q34-q35 defines a gene cluster for the most abundant GABAA receptor isoform. (PubMed id 7851879)^{2, 3} Russek S.J. and Farb D.H. (1994)
Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors. (PubMed id 8264558)^{3, 4} Hadingham K.L.... Ragan C.I. (1993)
No evidence for an association between variants at the gamma-amino-n-butyric acid type A receptor beta2 locus and schizophrenia. (PubMed id 17167345)^{1, 3} Jamra R.A....Schumacher J. (2007)
Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia. (PubMed id 18334916)^{1, 3} Inada T....Arinami T. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2561	HGNC: 4082	AceView: GABRB2	Ensembl:ENSG00000145864	euGenes: HUgn2561
ECgene: GABRB2	H-InvDB: GABRB2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
Protein Spotlight	http://www.expasy.org/spotlight/back_issues/sptlt056.shtml

Licensable Technologies for GABRB2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for GABRB2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GABRB2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GABRB2		Antibodies for GABRB2
	Explore super-pooled esiRNAs		Proteins for GABRB2
	Lentivirus-delivered shRNAs for GABRB2		Small molecules for GABRB2
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Recombinant Proteins (GABA A Receptor beta 2 + 3, GABA A Receptor beta 2)
	Antibodies (GABA A Receptor beta 2 + 3, GABA A Receptor beta 2)

Search OriGene for GABRB2

Tocris compounds for GABRB2

	Drugs for GABRB2
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

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GABRB2 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for GABRB2

Summaries
for GABRB2

Genomic Location
for GABRB2

Proteins
for GABRB2

Protein Domains/
Families
for GABRB2

Gene Function
for GABRB2

Pathways & Interactions
for GABRB2

Drugs & Compounds
for GABRB2

Transcripts
for GABRB2

Expression
for GABRB2

Orthologs
for GABRB2

Paralogs
for GABRB2

SNPs/Variants
for GABRB2

Disorders & Mutations
for GABRB2

Medical News
for GABRB2

Publications
for GABRB2

Search for GABRB2

Genome Databases showing GABRB2

Other Databases showing GABRB2

Specialized Databases showing GABRB2

Licensable Technologies
for GABRB2

Services
for GABRB2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GABRB2 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor GABRB2

Summariesfor GABRB2

Genomic Locationfor GABRB2

Proteinsfor GABRB2

Protein Domains/Familiesfor GABRB2

Gene Functionfor GABRB2

Pathways & Interactionsfor GABRB2

Drugs & Compoundsfor GABRB2

Transcriptsfor GABRB2

Expression for GABRB2

Orthologsfor GABRB2

Paralogsfor GABRB2

SNPs/Variantsfor GABRB2

Disorders & Mutationsfor GABRB2

Medical Newsfor GABRB2

Publicationsfor GABRB2

Search for GABRB2

Genome Databases showing GABRB2

Other Databases showing GABRB2

Specialized Databases showing GABRB2

Licensable Technologiesfor GABRB2

Servicesfor GABRB2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GABRB2

Summaries
for GABRB2

Genomic Location
for GABRB2

Proteins
for GABRB2

Protein Domains/
Families
for GABRB2

Gene Function
for GABRB2

Pathways & Interactions
for GABRB2

Drugs & Compounds
for GABRB2

Transcripts
for GABRB2

Expression
for GABRB2

Orthologs
for GABRB2

Paralogs
for GABRB2

SNPs/Variants
for GABRB2

Disorders & Mutations
for GABRB2

Medical News
for GABRB2

Publications
for GABRB2

Licensable Technologies
for GABRB2

Services
for GABRB2