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GABRB1 Gene

protein-coding   GIFtS: 69
GCID: GC04P046949

Gamma-Aminobutyric Acid (GABA) A Receptor, Beta 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Gamma-Aminobutyric Acid (GABA) A Receptor, Beta 11 2
GABA(A) Receptor Subunit Beta-12 3
Beta 11
GABA(A) Receptor1
GABA(A) Receptor, Beta 12
Gamma-Aminobutyric Acid Receptor Subunit Beta-12

External Ids:    HGNC: 40811   Entrez Gene: 25602   Ensembl: ENSG000001632887   OMIM: 1371905   UniProtKB: P185053   

Export aliases for GABRB1 gene to outside databases

Previous GC identifers: GC04P047104 GC04P047342 GC04P046883 GC04P046874 GC04P046728 GC04P046352


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GABRB1 Gene:
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest
inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1
subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1
subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia.
(provided by RefSeq, Jul 2008)

GeneCards Summary for GABRB1 Gene:
GABRB1 (gamma-aminobutyric acid (GABA) A receptor, beta 1) is a protein-coding gene. Diseases associated with GABRB1 include nicotine addiction, and autistic disorder. GO annotations related to this gene include chloride channel activity and GABA-A receptor activity. An important paralog of this gene is GLRA2.

UniProtKB/Swiss-Prot: GBRB1_HUMAN, P18505
Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by
binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

summary for GABRB1 Gene:
GABAA receptors are members of the cys-loop family of ligand-gated ion channels, responsible for mediating
the inhibitory effects of GABA alongside GABAB and GABAC receptors. They are pentameric proteins, consisting
of 5 subunits belonging to different families (alpha1-6, beta1-3, gamma1-3, delta, pi, epsilon, rho, theta).
The most abundant GABAA receptor in the mammalian brain consist of two copies each of alpha1 and beta2 with
a single gamma2 subunits. GABAA receptors contain an integral chloride channel, and have modulatory sites
for benzodiazepines, barbiturates, neurosteroids and ethanol.

Gene Wiki entry for GABRB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_006238.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the GABRB1 gene promoter:
         HOXA9   HOXA9B   NF-AT4   NF-AT2   HFH-1   NF-AT3   Meis-1a   NF-AT1   NF-AT   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGABRB1 promoter sequence
   Search Chromatin IP Primers for GABRB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GABRB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p12   Ensembl cytogenetic band:  4p12   HGNC cytogenetic band: 4p12

GABRB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GABRB1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P046949:  view genomic region     (about GC identifiers)

Start:
46,995,740 bp from pter      End:
47,428,462 bp from pter
Size:
432,723 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GBRB1_HUMAN, P18505 (See protein sequence)
Recommended Name: Gamma-aminobutyric acid receptor subunit beta-1 precursor  
Size: 474 amino acids; 54235 Da
Subunit: Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains:
alpha, beta, gamma, delta, and rho. Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the
pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response,
although to different extents (By similarity)
Secondary accessions: B2R6U7 Q16166 Q8TBK3

Explore the universe of human proteins at neXtProt for GABRB1: NX_P18505

Explore proteomics data for GABRB1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn105, Asn174
  • Modification sites at PhosphoSitePlus

  • See GABRB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000803.2  
    ENSEMBL proteins: 
     ENSP00000426753   ENSP00000295454   ENSP00000426766   ENSP00000440330  
    Reactome Protein details: P18505

    GABRB1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GABRA: Ligand-gated ion channels / GABA(A) receptors
    GABR: GABA receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: beta1
    GABAA receptors

    Selected InterPro protein domains (see all 6):
     IPR002289 GABAAb_rcpt
     IPR018000 Neurotransmitter_ion_chnl_CS
     IPR006028 GABAA_rcpt
     IPR006201 Neur_channel
     IPR006202 Neur_chan_lig-bd

    Graphical View of Domain Structure for InterPro Entry P18505

    ProtoNet protein and cluster: P18505

    3 Blocks protein domains:
    IPB002289 Gamma-aminobutyric-acid A receptor beta subunit signature
    IPB006028 Gamma-aminobutyric acid A (GABAA) receptor signature
    IPB006201 Neurotransmitter-gated ion-channel


    UniProtKB/Swiss-Prot: GBRB1_HUMAN, P18505
    Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC
    1.A.9.5) subfamily. GABRB1 sub-subfamily


    GABRB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBRB1_HUMAN, P18505
    Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by
    binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

         Genatlas biochemistry entry for GABRB1:
    gamma-aminobutyric acid (GABA) A receptor,ionotropic,beta subunit 1,component of a pentameric receptor mediating
    inhibitory neurotransmission,(no evident association of GABRB1 polymorphism (H396Q) with schizophrenia)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004890GABA-A receptor activity IEA--
    GO:0005230extracellular ligand-gated ion channel activity IEA--
    GO:0005253anion channel activity ----
    GO:0005254chloride channel activity IEA--
    GO:0050811GABA receptor binding ----
         
    GABRB1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GABRB1:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GABRB1
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate GABRB1 (see all 18):
    hsa-miR-30c hsa-miR-3616-5p hsa-miR-30d hsa-miR-103a hsa-miR-3125 hsa-miR-3916 hsa-miR-30a hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidGABRB1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GBRB1_HUMAN, P18505: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell
    membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus2
    endoplasmic reticulum1
    extracellular1
    lysosome1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope ----
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS2465923
    GO:0016020membrane ----

    GABRB1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GABRB1 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1GABA signaling in brain
    Synaptic Neurotransmission: GABAergic Inhibition0.32
    GABA signaling in brain0.32
    2Circadian entrainment
    GABAergic synapse0.53
    Retrograde endocannabinoid signaling0.51
    Morphine addiction0.53
    Serotonergic synapse0.33
    3Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    4Ligand-gated ion channel transport
    GABA A receptor activation0.00
    Ligand-gated ion channel transport
    5GABA receptor activation
    GABA receptor activation0.73

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for GABRB1
        Synaptic Neurotransmission: GABAergic Inhibition

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GABRB1
        Sperm Motility
    Akt Signaling

    1 Tocris Bioscience Pathway for GABRB1
        Akt Pathway

    2 GeneGo (Thomson Reuters) Pathways for GABRB1
        Signal transduction PKA signaling
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling


    2 Reactome Pathways for GABRB1
        GABA A receptor activation
    Ligand-gated ion channel transport


    Selected Kegg Pathways  (Kegg details for GABRB1) (see all 6):
        Neuroactive ligand-receptor interaction
    Retrograde endocannabinoid signaling
    Serotonergic synapse
    GABAergic synapse
    Morphine addiction


    GABRB1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GABRB1: 
              Neurotransmitter Receptors in human mouse rat
              GABA & Glutamate in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GABRB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for GABRB1 (P185053 ENSP000002954544) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARFGEF2Q9Y6D53, ENSP000003609854I2D: score=1 STRING: ENSP00000360985
    C1QBPQ070213, ENSP000002256984I2D: score=1 STRING: ENSP00000225698
    PIK3CAP423363, ENSP000002639674I2D: score=1 STRING: ENSP00000263967
    AKAP5P245883, ENSP000003156154I2D: score=1 STRING: ENSP00000315615
    GABRA1ENSP000000238974STRING: ENSP00000023897
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS2465923
    GO:0006811ion transport ----
    GO:0007165signal transduction TAS2465923
    GO:0007268synaptic transmission TAS--
    GO:0009636response to toxic substance ----

    GABRB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GABRB1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (+)-BicucullinePotent GABAA antagonist[485-49-4]
    MuscimolPotent GABAA agonist[2763-96-4]
    (-)-Bicuculline methiodideWater-soluble GABAA antagonist[40709-69-1]
    (-)-Bicuculline methochlorideWater-soluble GABAA antagonist[53552-05-9]
    SR 95531 hydrobromide Selective, competitive GABAA receptor antagonist [104104-50-9]

    2 HMDB Compounds for GABRB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    Gamma-Aminobutyric acid3-Carboxypropylamine (see all 27)56-12-2--

    Selected DrugBank Compounds for GABRB1 (see all 26)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    LindaneBenzene hexachloride (see all 11)58-89-9targetantagonist7885191 17139284 12645305 17016423 14635176 9530529 8841090 20600211 12614680 10592235 7566682
    Ketazolam-- 27223-35-4targetpotentiator18384456 11752090 15009644 2874815
    Lorazepam(+/-)-Lorazepam (see all 3)846-49-1targetpotentiator20138190 18384456 11752090
    Adinazolam-- 37115-32-5targetpotentiator6320036 6148400
    Chlordiazepoxide-- 58-25-3targetpotentiator18384456 11752090
    ClobazamAedon (see all 23)22316-47-8targetpotentiator18384456 11752090
    ClonazepamChlonazepam (see all 2)1622-61-3targetpotentiator18384456 11752090
    Clorazepate-- 23887-31-2targetpotentiator18384456 11752090
    Diazepam-- 439-14-5targetpotentiator18384456 11752090
    Estazolam-- 29975-16-4targetpotentiator639854 2889803

    2 IUPHAR Ligands for GABRB1 (beta1)    About this table
    LigandTypeActionAffinityPubmed IDs
    TBPS
    Channel blockerNone--
    picrotoxin
    Channel blockerNone--

    1 Novoseek inferred chemical compound relationship for GABRB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gaba 54.7 1 10447508 (1)



    GABRB1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GABRB1 gene: 
    NM_000812.3  

    Unigene Cluster for GABRB1:

    Gamma-aminobutyric acid (GABA) A receptor, beta 1
    Hs.27283  [show with all ESTs]
    Unigene Representative Sequence: AK127001
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000513567 ENST00000295454(uc003gxh.3 uc011bze.2) ENST00000509366(uc010igg.2)
    ENST00000381582(uc011bzd.1) ENST00000510909 ENST00000538619
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    hsa-miR-30c hsa-miR-3616-5p hsa-miR-30d hsa-miR-103a hsa-miR-3125 hsa-miR-3916 hsa-miR-30a hsa-miR-3148
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    Additional mRNA sequence: 

    AK127001.1 AK225167.1 AK225686.1 AK293691.1 AK296023.1 AK307120.1 AK312720.1 BC022449.1 
    X14767.1 

    7 DOTS entries:

    DT.100736124  DT.121242475  DT.306766  DT.100651213  DT.95226531  DT.86844311  DT.97804655 

    24 AceView cDNA sequences:

    T48783 CR614851 AU120212 AU146340 BX493012 X14767 CB117591 AK127001 
    BP345257 BC022449 AU099641 AL539372 BI915562 NM_000812 BM925256 AL539373 
    AW301170 BG709494 N55240 BG704311 R45230 R24969 BF364194 BP348730 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GABRB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTACAAACA
    GABRB1 Expression
    About this image


    GABRB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Neurons
             Glycinergic Amacrine Cells Inner Nuclear Layer
    GABRB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GABRB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.27283
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GABRB1: 
              Neurotransmitter Receptors in human mouse rat
              GABA & Glutamate in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GABRB1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GABRB1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABRB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GABRB1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gabrb11 , 5 gamma-aminobutyric acid (GABA) A receptor, subunit more1, 5 91.7(n)1
    98.1(a)1
      5 (38.18 cM)5
    144001  NM_008069.41  NP_032095.11 
     716999325 
    chicken
    (Gallus gallus)
    Aves GABRQ1 gamma-aminobutyric acid (GABA) A receptor, theta 68.29(n)
    71.61(a)
      396288  NM_001167703.1  NP_001161175.1 
    lizard
    (Anolis carolinensis)
    Reptilia GABRB16
    gamma-aminobutyric acid (GABA) A receptor, beta 1
    89(a)
    1 ↔ 1
    GL343293.1(153699-301301)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gabrb11 gamma-aminobutyric acid (GABA) A receptor, beta 1 76.23(n)
    87.13(a)
      100489344  XM_004911211.1  XP_004911268.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gabrb11 gamma-aminobutyric acid (GABA) A receptor, beta 1 73.9(n)
    84.12(a)
      100331377  XM_002664133.2  XP_002664179.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Lcch33 GABA-A receptor 48(a)
    (best of 6)
      14A1   --
    worm
    (Caenorhabditis elegans)
    Secernentea gab-13 GABA receptor 43(a)
    (best of 22)
      III(12844721-12850963)   --


    ENSEMBL Gene Tree for GABRB1 (if available)
    TreeFam Gene Tree for GABRB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GABRB1 gene
    GLRA22  GABRR12  GLRA12  GLRB2  GABRR32  GABRD2  GLRA42  GABRP2  
    GABRB32  GABRB22  GABRQ2  GLRA32  GABRR22  
    Selected SIMAP similar genes for GABRB1 using alignment to 4 protein entries:     GBRB1_HUMAN (see all proteins) (see all similar genes):
    GABRB3    DKFZp781L0846    GABRB2    GABRQ    GABRP    GABRA2
    GLRA4    GABRD    GABRA5    GABRE    GABRG3    GABRR2
    GABRA6    GABRG2    GABRR1    GABRR3    GLRA2    GABRA1

    GABRB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GABRB1 (see all 7747)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs356216971,2
    C--46643102(+) TTGAC-/TTTGTGA 1 -- int10--------
    rs287109471,2
    C,F--47031365(+) TATCTG/CATGAG 1 -- us2k19Minor allele frequency- C:0.42NA WA CSA EA 368
    rs1378800141,2
    --47031367(+) TCTCAC/TGAGTT 1 -- us2k10--------
    rs1845845751,2
    --47031482(+) ACAAAA/CCTTCT 1 -- us2k10--------
    rs1891010471,2
    --47031576(+) TTTTAA/GCATAG 1 -- us2k10--------
    rs1807346141,2
    --47031586(+) GTTATA/CGCAAT 1 -- us2k10--------
    rs1423096591,2
    --47031587(+) TTATCA/GCAATA 1 -- us2k10--------
    rs1865027431,2
    --47031588(+) TATCGC/GAATAA 1 -- us2k10--------
    rs1459406621,2
    --47031667(+) TCCTAA/TATAGT 1 -- us2k10--------
    rs1908454941,2
    --47031755(+) TAAAGA/TTCTAC 1 -- us2k10--------
    rs1816255701,2
    --47031845(+) GAGTAC/TTTCTG 1 -- us2k10--------
    rs1860842851,2
    --47031855(+) GTGCTC/TTCTAT 1 -- us2k10--------
    rs1482658821,2
    C--47031931(+) TCTATA/GTAGCA 1 -- us2k10--------
    rs1903568391,2
    --47032017(+) TCTTGA/GCTTTT 1 -- us2k10--------
    rs1129144281,2
    C--47032018(+) CTTGGC/ATTTTA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1413653861,2
    --47032028(+) ATTTAC/TCCCCT 1 -- us2k10--------
    rs285801211,2
    C,F--47032065(+) AGTTTA/GTTCAT 1 -- us2k1 tfbs32Minor allele frequency- G:0.15WA 120
    rs1829250381,2
    --47032160(+) TTCCCA/GATTAC 1 -- us2k10--------
    rs1881299761,2
    --47032191(+) TTATCC/TAGGTC 1 -- us2k10--------
    rs1507672411,2
    C--47032204(+) ATTTTC/GTGTAT 1 -- us2k10--------
    rs1391616361,2
    --47032250(+) TGTGCA/CTATTT 1 -- us2k10--------
    rs1497975211,2
    --47032310(+) TGGAAC/TAAATT 1 -- us2k10--------
    rs1908749211,2
    --47032348(+) CTCCTC/GTGTAG 1 -- us2k10--------
    rs1474939631,2
    --47032435(+) TCTCCC/TCTTTC 1 -- us2k10--------
    rs1826283221,2
    --47032742(+) CTGGCA/GAACAG 1 -- us2k10--------
    rs2019833721,2
    --47032880(+) CCTAG-/AAAAAA 1 -- us2k10--------
    rs1878051331,2
    --47032924(+) TTGTTC/TCCCTC 1 -- us2k10--------
    rs759502371,2
    F--47032935(+) ATTTCC/TCAACC 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1399854721,2
    --47032952(+) AAAAAA/CGACAA 1 -- us2k10--------
    rs1453235541,2
    --47033016(+) GCCTCC/TTACAG 1 -- us2k10--------
    rs1924664291,2
    --47033060(+) TCCCAA/TGGGCA 1 -- us2k10--------
    rs1476725661,2
    --47033099(+) CTGAGC/TTTCCT 1 -- us2k10--------
    rs1487875631,2
    --47033100(+) TGAGTC/TTCCTC 1 -- us2k10--------
    rs1830400321,2
    --47033205(+) TGCCCA/C/GCCACA 1 -- us2k10--------
    rs126467641,2
    C,F,H--47033226(+) GAACAA/CCAGAC 1 -- us2k16Minor allele frequency- C:0.08NS NA 796
    rs287145021,2
    C,F--47033241(+) CTCCAG/CAGTCC 1 -- us2k14Minor allele frequency- C:0.14NA WA 124
    rs1872866971,2
    --47033245(+) AGAGTA/CCCCGT 1 -- us2k10--------
    rs1929773551,2
    --47033247(+) AGTCCC/GCGTTC 1 -- us2k10--------
    rs1407320481,2
    C--47033323(+) CCAGT-/AAAAAA 1 -- ut510--------
    rs1424731731,2
    --47033409(+) ATGCTC/TGTAGG 1 -- ut510--------
    rs801519881,2
    C,F--47033562(+) GAGCGC/TGCTCT 1 -- ut511Minor allele frequency- T:0.01EA 120
    rs1513000231,2
    --47033580(+) CGCAGG/TTCCAT 1 -- ut510--------
    rs1405738021,2
    C--47033586(+) TCCATG/TCGGGA 1 -- ut510--------
    rs2006866431,2
    C--47033768(+) TTGAA-/TCTCGC
            
    TCTCT
    1 -- int10--------
    rs724160561,2
    C--47033771(+) AATCT-/CGCTCTC 1 -- int10--------
    rs117351121,2
    C,A,H--47033772(+) ATCTCT/GCTCTC 1 -- int12Minor allele frequency- G:0.25CSA 4
    rs2000203551,2
    --47033777(+) GCTCTA/CTCTCT 1 -- int10--------
    rs1458102641,2
    --47033787(+) TCTCTC/TTCTCT 1 -- int10--------
    rs285646721,2
    C--47033791(+) TCTCTC/TTTTTT 1 -- int1 trp32Minor allele frequency- T:0.25NA 4
    rs1486759611,2
    C--47033936(+) CACCAA/GTGAAC 2 N S mis11Minor allele frequency- G:0.00NA 4552
    rs3724586931,2
    C--47034050(+) CCTGTA/GACCCA 1 -- int10--------
    rs454609021,2
    C,F--47034075(+) TTTCTG/ATCAAA 1 -- int19Minor allele frequency- A:0.47WA NA CSA EA 370
    rs68479771,2
    C--47034104(+) AAAAAA/GAAAAG 1 -- int1 trp34Minor allele frequency- G:0.00NA WA 8
    rs677792591,2
    C--47034104(+) AAAAA-/GAAAAG 1 -- int10--------
    rs774726781,2
    C--47034136(+) GCACTC/ATACCC 1 -- int12Minor allele frequency- A:0.25NA 4
    rs3759115331,2
    C--47034144(+) CCTGG-/ACAC  
            
    GCACA
    1 -- int10--------
    rs732476291,2
    C,F--47034145(+) CCTGGA/GCACAC 1 -- int14Minor allele frequency- G:0.25WA NA 8
    rs284754941,2
    C--47034146(+) CTGGGG/CACACA 1 -- int11Minor allele frequency- C:0.50WA 2
    rs413057791,2
    C,F--47034350(+) ATGGAG/ATAAGG 1 -- int11Minor allele frequency- A:0.03NA 120
    rs2005347661,2
    C--47034421(+) GGCCCA/G/TCTCCC 1 -- int11EU 1269
    rs62851,2
    C,F--47034429(+) TCCCCA/GGCAGG 1 -- int10--------
    rs1848311881,2
    --47034537(+) CGGCTA/TACGCA 1 -- int10--------
    rs2011268271,2
    C--47034545(+) GCAGAC/TGGGAA 1 -- int10--------
    rs413092881,2
    C,F--47034626(+) CGCACG/CCGCTC 1 -- int19Minor allele frequency- C:0.44WA NA CSA EA EU 520
    rs1897304821,2
    --47035056(+) TGTTTC/GCTAGT 1 -- int10--------
    rs22367811,2
    C,F,A,H--47035087(+) GGTAGG/CCTTGT 1 -- int113Minor allele frequency- C:0.50EA NS WA NA CSA 2274
    rs121085811,2
    C,F--47035426(+) GTTGCT/GTCTCG 1 -- int19Minor allele frequency- G:0.49WA NA CSA EA 370
    rs1445781271,2
    --47035626(+) ATTGTC/TTTTCA 1 -- int10--------
    rs1923285641,2
    --47035649(+) TGTGTC/GGTTTT 1 -- int10--------
    rs121085901,2
    C,F--47035767(+) GTGACT/AATTTA 1 -- int110Minor allele frequency- A:0.49NA WA CSA EA 372
    rs1384090941,2
    --47035834(+) TATTTA/GTAAAT 1 -- int10--------
    rs1169706421,2
    C,F--47035967(+) AACCCA/GAAACA 1 -- int11Minor allele frequency- G:0.06EA 120
    rs1493178051,2
    C--47036035(+) AACTGA/GACAAA 1 -- int10--------
    rs1436270041,2
    C--47036149(+) AATTGA/TTAAAA 1 -- int10--------
    rs1480315141,2
    --47036481(+) GTATGA/CACTTG 1 -- int10--------
    rs1435860151,2
    --47036589(+) AGAAAA/GTAGAA 1 -- int10--------
    rs1836371591,2
    --47036632(+) TTTACC/TTGTTC 1 -- int10--------
    rs1896193511,2
    --47036719(+) CATTGA/TAATAA 1 -- int10--------
    rs1399455881,2
    C--47036808(+) TCAGAC/TGGTTA 1 -- int10--------
    rs1439213261,2
    --47036817(+) TAGCCC/TGCACC 1 -- int10--------
    rs1158902871,2
    F--47036846(+) ATTATA/GTGTTG 1 -- int11Minor allele frequency- G:0.01NA 120
    rs1818600711,2
    --47036874(+) AAATAA/GGGTAG 1 -- int10--------
    rs1506098451,2
    --47036947(+) CTGATA/CGGCAG 1 -- int10--------
    rs121086231,2
    C,F,A--47036985(+) TCATCT/AACATT 1 -- int18Minor allele frequency- A:0.48NA WA EA 368
    rs1397229741,2
    --47037033(+) ATCATA/GAAAAT 1 -- int10--------
    rs1498499471,2
    --47037093(+) TTTATA/GTTTTT 1 -- int10--------
    rs1458462931,2
    C--47037120(+) ACCCAC/TTCCAT 1 -- int10--------
    rs68467011,2
    C,F,A,H--47037199(+) TCTTTT/ACCATT 1 -- int121Minor allele frequency- A:0.18EA NA NS WA CSA 1003
    rs45728481,2
    C,F,A,H--47037271(+) ATCGTA/TTCAAG 1 -- int115Minor allele frequency- T:0.14NS EA NA WA 1202
    rs1862294681,2
    --47037484(+) ATATTA/GTTGAT 1 -- int10--------
    rs1900577211,2
    --47037660(+) ACAGAA/CACACA 1 -- int10--------
    rs623037431,2
    C,F--47037664(+) ACACAC/TACACA 1 -- int13Minor allele frequency- T:0.24NA 124
    rs1129810261,2
    C,F--47037682(+) ACACAG/CGCACA 1 -- int11Minor allele frequency- C:0.50CSA 2
    rs588329691,2
    C,F--47037795(+) GCCAGT/CAAAAC 1 -- int18Minor allele frequency- C:0.49WA NA CSA EA 368
    rs1443730431,2
    --47037907(+) AGTGAC/GTAGCT 1 -- int10--------
    rs1817012401,2
    --47037967(+) ACCAGG/TCAGCT 1 -- int10--------
    rs1466120271,2
    --47037970(+) AGGCAA/GCTCTC 1 -- int10--------
    rs774274531,2
    C,F--47038276(+) TTGTGG/ATTATT 1 -- int11Minor allele frequency- A:0.03NA 120
    rs1408892141,2
    --47038298(+) CTCTGA/GAAGTT 1 -- int10--------
    rs1145590021,2
    C,F--47038338(+) ACTATC/TACTGT 1 -- int11Minor allele frequency- T:0.01NA 120
    rs1132244701,2
    C,F--47038437(+) TGAATC/TACTCT 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1863696751,2
    --47038540(+) TAGATA/TGCACT 1 -- int10--------
    rs1511421201,2
    C--47038542(+) GATTGC/TACTTT 1 -- int10--------
    rs1401337911,2
    --47038566(+) GTACAC/TTATCC 1 -- int10--------
    rs125070121,2
    C,H--47038605(+) TGGGTG/ACAGTG 1 -- int113Minor allele frequency- A:0.18NA WA CSA EA 376
    rs1502996261,2
    --47038700(+) ATGGTA/GAAACC 1 -- int10--------
    rs1912697011,2
    --47038721(+) CAAAAG/TTATAC 1 -- int10--------
    rs1380609201,2
    C--47038835(+) AGATCA/GTGCCA 1 -- int10--------
    rs100269841,2
    C,F--47038887(+) aaaaaG/Aaaaaa 1 -- int1 trp31Minor allele frequency- A:0.06WA 118
    rs1997816531,2
    C--47038887(+) AAAAAG/-AAAAA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1137858501,2
    C--47038902(+) AAAAAA/GGAAAG 1 -- int12Minor allele frequency- G:0.17CSA EA 122
    rs1827393461,2
    --47038933(+) ATGAAA/CTTTTT 1 -- int10--------
    rs1850558511,2
    --47038937(+) ACTTTC/TTTTTT 1 -- int10--------
    rs1909894011,2
    --47039010(+) AGTTAA/GTGCCA 1 -- int10--------
    rs1437499711,2
    C--47039041(+) AAGCAA/GCAGGA 1 -- int10--------
    rs1831764611,2
    --47039090(+) AATAAA/GTAGTC 1 -- int10--------
    rs1876003311,2
    --47039267(+) AGCTAA/GCAATA 1 -- int10--------
    rs131163551,2
    C,F,H--47039315(+) CAGTAA/GGTTCT 1 -- int121Minor allele frequency- G:0.15NS EA NA WA 2354
    rs623037441,2
    C,F--47039332(+) TTATAA/CTAGAA 1 -- int12Minor allele frequency- C:0.08NA 122
    rs1929440461,2
    --47039337(+) ATAGAA/GTTTCC 1 -- int10--------
    rs1459150791,2
    C--47039429(+) TATGAA/GTAATC 1 -- int10--------
    rs1114055331,2
    C,F--47039476(+) TATAAC/TGTCTG 1 -- int11Minor allele frequency- T:0.50NA 2
    rs1439131041,2
    --47039486(+) GGAGAA/GGCTGG 1 -- int10--------
    rs1834720651,2
    --47039544(+) ATATTA/CGTTTT 1 -- int10--------
    rs76729431,2
    C,F,A--47039546(+) ATTCGG/TTTTTT 1 -- int114Minor allele frequency- T:0.50NA WA CSA EA 504
    rs558402601,2
    C,F--47039552(+) TTTTTG/TTTGTT 1 -- int12Minor allele frequency- T:0.50WA 4
    rs1146345981,2
    F--47039622(+) AGATTG/ATTTTA 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1880168401,2
    --47039644(+) TACATG/TTGAAA 1 -- int10--------
    rs1161271991,2
    --47039669(+) GATTGC/TAGAAT 1 -- int10--------
    rs1487468911,2
    --47039738(+) TTCCAC/TATGTG 1 -- int10--------
    rs1928949121,2
    --47039757(+) TTATCA/TGTGCT 1 -- int10--------
    rs1413916111,2
    --47039785(+) TAATCC/TTTTAC 1 -- int10--------
    rs1508305061,2
    --47039813(+) TTACCC/TCTCCC 1 -- int10--------
    rs1838943561,2
    --47039862(+) GAAATA/GTTGTT 1 -- int10--------
    rs786501501,2
    F--47039990(+) TAGGAC/TTTTGA 1 -- int11Minor allele frequency- T:0.01NA 120
    rs1397407291,2
    --47040059(+) TGCTAA/TACCCT 1 -- int10--------
    rs1882280281,2
    --47040377(+) AAGCAA/GTGATC 1 -- int10--------
    rs1445452841,2
    --47040410(+) GCCTGA/GTTTAT 1 -- int10--------
    rs64475251,2
    C,F,H--47040669(+) GAATAT/CCACTT 1 -- int123Minor allele frequency- C:0.01NA NS EA WA CSA 1752
    rs1131326071,2
    C,F--47040931(+) GTACAC/TAGTTC 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1445652001,2
    C--47040967(+) ATTCC-/TTTTCC 1 -- int10--------
    rs1401535481,2
    --47041009(+) TTTCAA/TGAAGT 1 -- int10--------
    rs1912931121,2
    --47041105(+) GAAAAC/TGTTTA 1 -- int10--------
    rs1850032831,2
    --47041114(+) TACGAC/TTAATT 1 -- int10--------
    rs1904538391,2
    --47041177(+) AGATGC/TATTTT 1 -- int10--------
    rs1817628281,2
    --47041231(+) TCTTCA/GTTGCT 1 -- int10--------
    rs1432585311,2
    --47041287(+) TCCCCA/GATAAA 1 -- int10--------
    rs766802051,2
    C,F--47041294(+) TAAAAT/CCTGTT 1 -- int11Minor allele frequency- C:0.16EA 120
    rs784671991,2
    C,F--47041300(+) CTGTTG/TTTGCA 1 -- int11Minor allele frequency- T:0.14EA 120
    rs2021791421,2
    C--47041377(+) AATAC-/AAAAAAA 1 -- int10--------
    rs1999472721,2
    --47041526(+) GCATA-/TTTTTT 1 -- int10--------
    rs1869406021,2
    --47041610(+) TATGTA/GTAGGA 1 -- int10--------
    rs1454910041,2
    C--47041618(+) GGATCC/TTATGG 1 -- int10--------
    rs1157623891,2
    F--47041680(+) GAATCT/CTAGAA 1 -- int11Minor allele frequency- C:0.01WA 118
    rs1488513151,2
    --47041798(+) ATGAAC/GTGTTC 1 -- int10--------
    rs1424937611,2
    --47041879(+) CATGCG/TAAAAG 1 -- int10--------
    rs767824591,2
    F--47042360(+) TCAAGG/ATCCAG 1 -- int11Minor allele frequency- A:0.01WA 118
    rs799421511,2
    F--47042413(+) TAGACA/GGAAAA 1 -- int11Minor allele frequency- G:0.02WA 118
    rs623037451,2
    C,F--47042529(+) TGACAT/GCGGGG 1 -- int15Minor allele frequency- G:0.13NA WA 244
    rs769596231,2
    C,F--47042531(+) ACATCG/AGGGCT 1 -- int11Minor allele frequency- A:0.14EA 120
    rs1509348171,2
    --47042562(+) CCCAGA/GGCCAG 1 -- int10--------
    rs1422567881,2
    --47042587(+) CTCTTC/TCACTG 1 -- int10--------
    rs1462680881,2
    --47042603(+) GTGGAC/TACATT 1 -- int10--------
    rs1388206471,2
    --47042991(+) ATAGAC/TGTGTG 1 -- int10--------
    rs1412937641,2
    --47043063(+) CCTTCC/TGGAAC 1 -- int10--------
    rs1897913211,2
    --47043148(+) TGAAAC/TGAGAC 1 -- int10--------
    rs1811013111,2
    --47043177(+) CAAATA/GAGGCT 1 -- int10--------
    rs1503515221,2
    --47043278(+) GACTGC/TTGGGT 1 -- int10--------
    rs1851971221,2
    --47043301(+) AAGAAC/TTCAAG 1 -- int10--------
    rs1897655941,2
    --47043492(+) GAAAAA/GAGTAT 1 -- int10--------
    rs1387766301,2
    --47043534(+) ATTAGA/TGGTTA 1 -- int10--------
    rs1493815271,2
    --47043539(+) AGGTTA/CGATGC 1 -- int10--------
    rs1446703981,2
    --47043573(+) TTAATC/TAGAGA 1 -- int10--------
    rs1165953851,2
    F--47043653(+) GATTTG/CTCGAA 1 -- int11Minor allele frequency- C:0.01WA 118
    rs1821072201,2
    --47043901(+) TGCCTC/TTAGGT 1 -- int10--------
    rs1382450301,2
    --47043919(+) AAATCA/GTATTT 1 -- int10--------
    rs1871868511,2
    --47043994(+) CATATG/TAGGAA 1 -- int10--------
    rs1430558761,2
    --47044029(+) ACCCAA/GTATAA 1 -- int10--------
    rs73562951,2
    C--47044039(+) ATTTAA/GGAATT 1 -- int10--------
    rs284292021,2
    C,F--47044088(+) CTACTA/GTGTAA 1 -- int13Minor allele frequency- G:0.15WA 122
    rs1461651591,2
    --47044105(+) GGAAGC/TTTAGA 1 -- int10--------
    rs1835979891,2
    --47044128(+) ATATTC/TTCTAT 1 -- int10--------
    rs1886455811,2
    --47044162(+) GACTGA/GATAAT 1 -- int10--------
    rs1913215831,2
    --47044215(+) ATATAA/GCATTT 1 -- int10--------
    rs1827327461,2
    --47044357(+) TTTCAA/CAGACA 1 -- int10--------
    rs352566691,2
    C--47044393(+) ATGCA-/TGTGTAT 1 -- int10--------
    rs76540581,2
    C,A--47044458(+) ATATAA/TAATAC 1 -- int13Minor allele frequency- T:0.34NA 124
    rs1870660871,2
    --47044463(+) AAATAC/TGTGTG 1 -- int10--------
    rs2001988391,2
    --47044468(+) CGTGT-/GTGA  
            
    GTATG
    1 -- int10--------
    rs1914454541,2
    --47044520(+) ATAGTC/TTGCTT 1 -- int10--------
    rs556980131,2
    C,F--47044723(+) AGGGAT/CTTTTA 1 -- int16Minor allele frequency- C:0.48WA CSA NA EA 364
    rs1146035501,2
    F--47044898(+) ATGTAT/CACATA 1 -- int11Minor allele frequency- C:0.01NA 120
    rs76763271,2
    C,F,A,H--47044999(+) AATGTG/AGTAAA 1 -- int120Minor allele frequency- A:0.45NS EA NA WA CSA 2338
    rs789692931,2
    F--47045089(+) CCTGCC/TCCCAT 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1423789171,2
    C--47045181(+) ATTCAC/TGACAG 1 -- int10--------
    rs1162737661,2
    F--47045197(+) AATATT/AGGCCA 1 -- int11Minor allele frequency- A:0.02WA 118
    rs76826251,2
    C,F--47045200(+) ATTGGC/GCAACT 1 -- int18Minor allele frequency- G:0.50WA NA CSA EA 368
    rs1836465491,2
    --47045203(+) GGCCAA/GCTGAA 1 -- int10--------
    rs1889455681,2
    --47045342(+) GTGGGC/TTATTT 1 -- int10--------
    rs43171791,2
    C,F,A,H--47045377(+) AACATC/TGCTAC 1 -- int128Minor allele frequency- T:0.16NS EA NA WA CSA 2473
    rs1508830241,2
    --47045439(+) ATAACG/TTGGTT 1 -- int10--------
    rs74363861,2
    H--47045471(+) TGACTT/ATCAGG 1 -- int14Minor allele frequency- A:0.00NS EA 412
    rs623052801,2
    C,F--47045524(+) GTTACC/AAGACA 1 -- int19Minor allele frequency- A:0.49WA NA CSA EA 370
    rs1932528291,2
    --47045539(+) TTTAAC/TTTGAT 1 -- int10--------
    rs1153310231,2
    F--47045542(+) AACTTG/AATGAA 1 -- int11Minor allele frequency- A:0.02WA 118
    rs789235951,2
    C,F--47045566(+) TAGTCA/TCTGTT 1 -- int11Minor allele frequency- T:0.15EA 120
    rs1390732571,2
    --47045611(+) CCTTTA/GGTTCT 1 -- int10--------
    rs1499133071,2
    --47045623(+) CAAAAC/TGGACA 1 -- int10--------
    rs1852694641,2
    --47045823(+) TATTAA/GAACTT 1 -- int10--------
    rs1901702561,2
    --47045831(+) CTTGAA/TGTATT 1 -- int10--------
    rs1475561821,2
    --47045875(+) TGAGAG/TAGGAA 1 -- int10--------
    rs1160550801,2
    F--47045970(+) GAGATT/GAGAAA 1 -- int11Minor allele frequency- G:0.01WA 118
    rs1118179421,2
    C,F--47046013(+) TTTCAC/TACGTT 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1420034651,2
    --47046038(+) AATTTC/TCTGAA 1 -- int10--------
    rs1442139821,2
    C--47046113(+) GCCTAA/CACTGA 1 -- int10--------
    rs1478386441,2
    --47046139(+) AAGCAC/TTTTGC 1 -- int10--------
    rs1414644731,2
    --47046140(+) AGCATG/TTTGCT 1 -- int10--------
    rs1840628431,2
    C--47046160(+) AGTGAC/TGCCTA 1 -- int10--------
    rs1883564101,2
    --47046161(+) GTGACA/GCCTAA 1 -- int10--------
    rs117273281,2
    C,F,A,H--47046219(+) TGCTTG/ATGTAA 1 -- int112Minor allele frequency- A:0.14NS EA NA CSA WA 758
    rs73562781,2
    C,F,A--47046284(+) TCTCAC/TAGTTA 1 -- int115Minor allele frequency- T:0.44EA NA WA CSA 566
    rs1808713911,2
    --47046329(+) TCTTTC/TAAGTC 1 -- int10--------
    rs1860458831,2
    --47046384(+) AAGTAA/CCTTTC 1 -- int10--------
    rs1435324841,2
    --47046579(+) GAGTGC/TCACGA 1 -- int10--------
    rs623052811,2
    C,F--47046769(+) AAATAT/CAATAT 1 -- int14Minor allele frequency- C:0.24NA 126
    rs1996168871,2
    --47046774(+) TAATA-/TTTTTG 1 -- int10--------
    rs711938981,2
    C--47046859(+) TAAAA-/ATCAAA 1 -- int12Minor allele frequency- A:0.25NA 4
    rs790659041,2
    C,F--47046935(+) AACCAC/TGTTAC 1 -- int11Minor allele frequency- T:0.09WA 118
    rs1480432941,2
    --47046961(+) AAAATG/TTCAAT 1 -- int10--------
    rs1921218961,2
    --47046965(+) TTTCAA/GTTGGT 1 -- int10--------
    rs99998041,2
    C,F,A--47046967(+) TCAATC/TGGTAT 1 -- int110Minor allele frequency- T:0.45NA WA CSA EA 371
    rs1823236371,2
    --47047023(+) CTTTAC/TATGAG 1 -- int10--------
    rs1404876761,2
    --47047207(+) ATGAAA/CATGGG 1 -- int10--------
    rs1151101301,2
    F--47047262(+) TTCCTA/GGGAAA 1 -- int11Minor allele frequency- G:0.01WA 118
    rs1870543101,2
    --47047269(+) GAAACC/TCAGGA 1 -- int10--------
    rs1907262601,2
    --47047433(+) ACTGGC/TCATTT 1 -- int10--------
    rs753944331,2
    C--47047463(+) TTATCA/TTCATC 1 -- int10--------
    rs361180871,2
    C--47047503(+) CATCA-/TCAGTCCA 1 -- int11Minor allele frequency- TCA:0.00NA 2
    rs1828686061,2
    --47047665(+) TTCACA/GTGGTG 1 -- int10--------
    rs1504421811,2
    --47047709(+) CTGGAA/GCCTCT 1 -- int10--------
    rs1382034741,2
    --47047762(+) ATAACC/TTCCCA 1 -- int10--------
    rs45743821,2
    C,F,A,H--47047786(+) caaatA/Gttgtt 1 -- int116Minor allele frequency- G:0.45NS EA NA WA CSA 793
    rs1872109141,2
    --47047860(+) CATTAC/TCATCA 1 -- int10--------
    rs1427215801,2
    C--47047876(+) ATCCTA/GTTTAT 1 -- int10--------
    rs1460607401,2
    --47047881(+) ATTTAC/TTCAAC 1 -- int10--------
    rs1390011411,2
    --47047901(+) GTAACC/TAGGCA 1 -- int10--------
    rs68372551,2
    C,H--47047956(+) aatctC/Tacctt 1 -- int114Minor allele frequency- T:0.16NA WA CSA EA 378
    rs100005681,2
    C,F--47047985(+) accctA/Gtgtgt 1 -- int11Minor allele frequency- G:0.05WA 118
    rs1902174381,2
    --47048095(+) TATAAA/GCATCT 1 -- int10--------
    rs43746011,2
    C,F,H--47048119(+) CTTACA/CCTTCT 1 -- int1 trp313Minor allele frequency- C:0.19NA WA CSA EA 377
    rs1146453181,2
    C,F--47048309(+) ACAATA/GAAATT 1 -- int11Minor allele frequency- G:0.01NA 120
    rs731450851,2
    C--47048358(+) TGTAGA/GTAATC 1 -- int13Minor allele frequency- G:0.12WA NA 240
    rs1494343841,2
    --47048370(+) AACAAA/GCAAAA 1 -- int10--------
    rs1824922541,2
    --47048387(+) TTTATC/GTGTTC 1 -- int10--------
    rs1877917281,2
    --47048478(+) CTTTAC/TTTTTT 1 -- int10--------
    rs1447769431,2
    C--47048531(+) AGATAA/GCTATC 1 -- int10--------
    rs1931315141,2
    --47048576(+) AAAAAG/TGTCCT 1 -- int10--------
    rs126512991,2
    C,F,H--47048585(+) CTGAAT/GATGAG 1 -- int110Minor allele frequency- G:0.48NA WA CSA EA 372
    rs1485667811,2
    --47048659(+) ATGCAA/GGAGAA 1 -- int10--------
    rs358782101,2
    C--47048720(+) TTAGG-/AAATCT 1 -- int10--------
    rs1857400251,2
    --47048735(+) CAATAA/GCAAAG 1 -- int10--------
    rs1886575201,2
    --47048988(+) AACAAC/TGTGCA 1 -- int10--------
    rs1921023351,2
    --47049076(+) CCTGGA/GTGATG 1 -- int10--------
    rs1416784531,2
    --47049189(+) CAAAAC/TAGTCT 1 -- int10--------
    rs1841949051,2
    --47049221(+) AATAAC/TCTGTA 1 -- int10--------
    rs1404080181,2
    --47049361(+) AACCAC/TTTTAT 1 -- int10--------
    rs1887022561,2
    --47049447(+) AAACTA/GAGATA 1 -- int10--------
    rs1441760581,2
    --47049484(+) GTTATA/GTAACA 1 -- int10--------
    rs1811887671,2
    --47049583(+) AAACAC/TCATTA 1 -- int10--------
    rs1844647901,2
    --47049653(+) AGAAAC/TTGGGT 1 -- int10--------
    rs1150706311,2
    C,F--47049678(+) CATTAG/ACAATT 1 -- int11Minor allele frequency- A:0.02NA 120
    rs1164218851,2
    F--47049711(+) AACTTT/CATAAA 1 -- int11Minor allele frequency- C:0.07WA 118
    rs731450901,2
    C--47049725(+) AAGGAG/ACAGTT 1 -- int13Minor allele frequency- A:0.11WA NA 240
    rs1895197611,2
    --47049837(+) AGGAAC/GAGATA 1 -- int10--------
    rs1477756291,2
    --47049899(+) TTAAAC/TTGGAC 1 -- int10--------
    rs1391916321,2
    --47050171(+) AAAAAC/TCCCCA 1 -- int10--------
    rs1499649691,2
    --47050198(+) TTAGTA/GTATAT 1 -- int10--------
    rs1807649221,2
    --47050199(+) TAGTAC/TATATA 1 -- int10--------
    rs1136821651,2
    C,F--47050223(+) TTATTC/TAGTCA 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs764942831,2
    --47050250(+) GACAAC/TGACAA 1 -- int10--------
    rs1431354251,2
    --47050431(+) GGAGTA/CTTTTG 1 -- int10--------
    rs1874100801,2
    --47050449(+) GACTTC/TTTGAA 1 -- int10--------
    rs1908780621,2
    --47050461(+) ACAATA/GACCAC 1 -- int10--------
    rs1465624071,2
    C--47050490(+) TAAGAA/GCCTTA 1 -- int10--------
    rs1413083481,2
    --47050558(+) AGTCTA/GTCTGT 1 -- int10--------
    rs1130094101,2
    C,F--47050630(+) AAAATG/CTAATG 1 -- int11Minor allele frequency- C:0.50CSA 2
    rs1817347051,2
    --47050737(+) ATAAAG/TAACTG 1 -- int10--------
    rs1860906671,2
    --47050842(+) CAACAA/CTAATT 1 -- int10--------
    rs1388312941,2
    --47050857(+) TCCCTG/TTAGAG 1 -- int10--------
    rs1996614771,2
    C--47050976(-) GGCTTG/TTTTTG 1 -- int10--------
    rs1903675361,2
    --47051024(+) CTTACC/TTAGGG 1 -- int10--------
    rs1415635921,2
    --47051047(+) ACAGAA/GCCTTT 1 -- int10--------
    rs1504951451,2
    C--47051054(+) CTTTCC/TTCTTA 1 -- int10--------
    rs58580511,2
    C--47051081(+) AAGAG-/AAAAAA 1 -- int1 trp31Minor allele frequency- A:0.00CSA 2
    rs1145406091,2
    C,F--47051108(+) CCAGAG/AGAGGG 1 -- int11Minor allele frequency- A:0.04WA 118
    rs1383331921,2
    C--47051151(+) TCCCTC/GCTTTG 1 -- int10--------
    rs43157501,2
    C,F,A,H--47051185(+) GGAGGC/AAACAC 1 -- int1 trp324Minor allele frequency- A:0.18NS EA NA WA CSA 1344
    rs669684751,2
    C,F--47051220(+) AGCAAG/AGGCGA 1 -- int110Minor allele frequency- A:0.47WA NA CSA EA 371
    rs1162833541,2
    F--47051224(+) AAGGCG/AATTTG 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1496026681,2
    --47051353(+) GGCCGG/TACGTC 1 -- int10--------
    rs76863281,2
    C,F--47051423(+) CAGACA/GACCAA 1 -- int110Minor allele frequency- G:0.50NA WA CSA EA 372
    rs286259711,2
    F--47051501(+) TGAGAG/CAGAAA 1 -- int1 trp31Minor allele frequency- C:0.07WA 118
    rs1832256641,2
    --47051503(+) AGAGAG/TAAATC 1 -- int10--------
    rs285393871,2
    F--47051539(+) CATTTC/TATCAC 1 -- int11Minor allele frequency- T:0.07WA 118
    rs131204781,2
    H--47051865(+) TGTTGT/GTTCTG 1 -- int14Minor allele frequency- G:0.00NS EA 394
    rs1473051221,2
    --47051924(+) CTGCTG/TCCATT 1 -- int10--------
    rs284063181,2
    F--47051986(+) TACTAC/TTCACT 1 -- int11Minor allele frequency- T:0.07WA 118
    rs716119911,2
    C,F--47052069(+) TTAGCA/CAGCAA 1 -- int13Minor allele frequency- C:0.04NA 124
    rs1403647231,2
    --47052197(+) GCTTCA/GAAGGT 1 -- int10--------
    rs1427715951,2
    --47052198(+) CTTCAA/CAGGTG 1 -- int10--------
    rs1473473371,2
    C--47052244(+) CAAAGA/TGAACT 1 -- int10--------
    rs1862046381,2
    --47052347(+) CAGACC/TAGTAC 1 -- int10--------
    rs68289301,2
    C,F--47052434(+) CAAATG/ATATGT 1 -- int18Minor allele frequency- A:0.50WA NA CSA EA 367
    rs347991141,2
    C--47052446(+) ATACG-/A/T/TA
            
    TATAT
    1 -- int11NA 2
    rs1484157791,2
    --47052452(+) TATATA/GTATAT 1 -- int10--------
    rs1426832741,2
    --47052470(+) TATATA/TTTTTT 1 -- int10--------
    rs1911075331,2
    --47052568(+) GGAAGA/CAAAGA 1 -- int10--------
    rs68292061,2
    C,F,A,H--47052606(+) ATACCT/AGCTTA 1 -- int115Minor allele frequency- A:0.19EA NS NA WA CSA 633
    rs68344211,2
    C,F--47052626(+) TTGGAC/TACCTG 1 -- int110Minor allele frequency- T:0.49NA WA CSA EA 372
    rs1509988671,2
    --47052814(+) ATTCAA/TTTTCA 1 -- int10--------
    rs1823505321,2
    --47052836(+) GTTTCC/TTCTCT 1 -- int10--------
    rs1396224911,2
    --47053003(+) TTTTGC/TGTGTG 1 -- int10--------
    rs1433433931,2
    --47053271(+) GTTAAC/TGAGCC 1 -- int10--------
    rs1163685541,2
    F--47053366(+) CAGAAT/CAGAAA 1 -- int11Minor allele frequency- C:0.03WA 118
    rs1877874361,2
    --47053403(+) TTGGAA/GACAAA 1 -- int10--------
    rs1467295751,2
    --47053416(+) AAACTA/GAGAAA 1 -- int10--------
    rs1924516061,2
    --47053689(+) AATAAC/GAGTTC 1 -- int10--------
    rs76999991,2
    C,F--47053769(+) GCACTA/GGACTT 1 -- int110Minor allele frequency- G:0.49NA WA CSA EA 372
    rs344294391,2
    C,F--47053833(+) TCAGCC/TGACTA 1 -- int13