GABRB1 Gene

Aliases
for GABRB1 gene

Previous GC identifers: GC04P047104 GC04P047342 GC04P046883 GC04P046874 GC04P046728 GC04P046352

Summaries
for GABRB1 gene

Genomic Views
for GABRB1 gene

RefSeq DNA sequence:

NC_000004.11  NC_018915.1  NT_006238.11  

SwitchGear Promoter luciferase reporter plasmid: GABRB1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GABRB1

GABRB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P046949:  view genomic region     (about GC identifiers)

Proteins
for GABRB1 gene

Explore the universe of human proteins at neXtProt for GABRB1: NX_P18505

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: GABRB1 OriGene Custom Protein Services for GABRB1
	GenScript Custom Purified and Recombinant Proteins Services for GABRB1
	Novus Biologicals GABRB1 Protein Novus Biologicals GABRB1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of GABRB1
	R&D Systems Antibodies for GABRB1 (GABA-A R beta 1)
	Browse OriGene Antibodies OriGene Custom Antibody Services for GABRB1
	GenScript Superior Antibodies for GABRB1
	Novus Biologicals GABRB1 Antibodies
	Abcam antibodies for GABRB1
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for GABRB1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for GABRB1
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

Protein Domains /
Families
for GABRB1 gene

ProtoNet protein and cluster: P18505

Function
for GABRB1 gene

miRNA Products:		OriGene 3'-UTR Clone: GABRB1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GABRB1
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate GABRB1 (see all 18):
		hsa-miR-30c hsa-miR-3616-5p hsa-miR-30d hsa-miR-103a hsa-miR-3125 hsa-miR-3916 hsa-miR-30a hsa-miR-3148
		SwitchGear 3'UTR luciferase reporter plasmid: GABRB1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GABRB1 (see all 7) OriGene shRNA RFP: GABRB1 OriGene siRNA: GABRB1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GABRB1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for GABRB1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GABRB1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GABRB1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GABRB1 (NM_000812)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GABRB1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GABRB1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GABRB1
		Search LifeMap BioReagents cell lines for GABRB1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABRB1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for GABRB1 gene

	Super-pathway	contained gene-specific pathways
1	GABA A receptor activation	GABA A receptor activation 1.00 Synaptic Neurotransmission: GABAergic Inhibition 0.45 Ligand-gated ion channel transport 0.48 GABA signaling in brain 0.26
2	Transmission across Chemical Synapses	Transmission across Chemical Synapses 1.00 Neuronal System 0.67 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell 0.72
3	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling 1.00 Neurophysiological process_Glutamate regulation of Dopamine D1A receptor signaling 0.98
4	G Protein Signaling Pathways	Signal transduction PKA signaling 0.23 Signal transduction_PKA signaling 0.23
5	Ion channel transport	Ion channel transport 1.00

3 EMD Millipore Pathways for GABRB1

	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
	GABA signaling in brain
	Signal transduction PKA signaling

1 R&D Systems Pathway for GABRB1

Synaptic Neurotransmission: GABAergic Inhibition

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GABRB1

	Sperm Motility
	Akt Signaling

1 Tocris Bioscience Pathway for GABRB1

Akt Pathway

2 GeneGo (Thomson Reuters) Pathways for GABRB1

	Signal transduction PKA signaling
	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

5/8        Reactome Pathways for GABRB1

	GABA A receptor activation
	Ligand-gated ion channel transport
	Transmission across Chemical Synapses
	Ion channel transport
	Neuronal System

1         Kegg Pathway  (Kegg details for GABRB1)

Neuroactive ligand-receptor interaction

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

Drugs & Compounds
for GABRB1 gene

Transcripts
for GABRB1 gene

Expression
for GABRB1 gene

GABRB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTACAAACA

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	EyeInner Nuclear LayerType1 Off Cone Bipolar Cells			Bipolar, Retina
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 3 LifeMap Cells
	Name			Category
	PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)			Adipose, Bone, Cartilage
	PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
	PureStem™ progenitor W10 (Embryonic Progenitor Cell)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GABRB1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GABRB1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GABRB1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GABRB1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABRB1

Orthologs
for GABRB1 gene

Paralogs
for GABRB1 gene

Paralogs for GABRB1 gene

GLRA2²  GABRR1²  GLRB²  GLRA1²  GABRD²  GLRA4²  GABRP²  GABRB2²  

GABRQ²  GABRB3²  GLRA3²  GABRR2²  

18/24 SIMAP similar genes for GABRB1 using alignment to 4 protein entries:     GBRB1_HUMAN (see all proteins) (see all similar genes):

GABRB3    DKFZp781L0846    GABRB2    GABRQ    GABRP    GABRA3

GABRA2    GLRA4    GABRD    GABRA5    GABRE    GABRR2

GABRA6    GABRG3    GABRR1    GABRR3    GLRA2    GABRA1

GABRB1 for paralogs           About GeneDecksing

Genomic Variants
for GABRB1 gene

Disorders / Diseases
for GABRB1 gene

Publications
for GABRB1 gene

PubMed articles for GABRB1 gene, integrated from 9 sources (see all 78) (see top 10): (articles sorted by number of sources associating them with GABRB1)

Utopia: connect your pdf to the dynamic world of online information

1. Lack of GABABR1 gene variation (G1465A) in a Chinese population with temporal lobe epilepsy. (PubMed id 16278087)^{1, 4} Ren L....Shen Y. (2005)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
3. GABA(B) receptor 1 polymorphism (G1465A) is associated with temporal lobe epilepsy. (PubMed id 12601092)^{1, 4} Gambardella A....Quattrone A. (2003)
4. Exonic variants of the GABA(B) receptor gene and panic disorder. (PubMed id 11324945)^{1, 4} Sand P.G....Deckert J. (2000)
5. Search for mutations in the beta 1 GABAA receptor subunit gene in patients with schizophrenia. (PubMed id 8178835)^{1, 2} Coon H.... Wender P. (1994)
6. Isolation, characterization, and localization of human genomic DNA encoding the beta 1 subunit of the GABAA receptor (GABRB1). (PubMed id 1655634)^{1, 2} Kirkness E.F.... Venter J.C. (1991)
7. Differential expression of gamma-aminobutyric acidA receptor subunits. (PubMed id 2160058)^{1, 2} Garrett K.M.... Blume A.J. (1990)
8. Sequence and expression of human GABAA receptor alpha 1 and beta 1 subunits. (PubMed id 2465923)^{1, 2} Schofield P.R....Seeburg P.H. (1989)
9. Human chromosomes 11p15 and 4p12 and alcohol dependence: possible association with the GABRB1 gene. (PubMed id 10490712)^{4, 9} Parsian A. and Zhang Z.H. (1999)
10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
11. Amygdala gene expression of NMDA and GABA(A) receptors in patients with mesial temporal lobe epilepsy. (PubMed id 20848605)¹ de Moura J.C....Carlotti Junior C.G. (2012)
12. New insight into the central benzodiazepine receptor- ligand interactions: design, synthesis, biological evaluation, and molecular mo deling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and rela ted compounds. (PubMed id 21751815)¹ Anzini M....Biggio G. (2011)
13. [The expression of GABA(A) receptor alpha1 and GABA(B) receptor 1 in medulla oblongata solitary nucleus and ambiguous nucleus in the c ases of tramadol intoxication]. (PubMed id 22393585)¹ Zhang S....Fan Y.Y. (2011)
14. Lamina-specific alterations in cortical GABA(A) recept or subunit expression in schizophrenia. (PubMed id 20843900)¹ Beneyto M....Lewis D.A. (2011)
15. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)¹ Pinheiro A.P....Woodside D.B. (2010)
16. Dual actions of lindane (I^-hexachlorocyclohexane) on calcium homeostasis and exocytosis in rat PC12 cells. (PubMed id 20600211)⁷ Heusinkveld H.J....Westerink R.H. (2010)
17. Atypical behavioural effects of lorazepam: clues to t he design of novel therapies? (PubMed id 20138190)⁷ Giersch A....Vidailhet P. (2010)
18. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)¹ Bennett E.J....Harper J.W. (2010)
19. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
20. Genetic utility of broadly defined bipolar schizoaffe ctive disorder as a diagnostic concept. (PubMed id 19567891)¹ Hamshere M.L....McGuffin P. (2009)
21. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)¹ Tabakoff B....Hoffman P.L. (2009)
22. Multiple modes for conferring surface expression of homomeric beta1 GABAA receptors. (PubMed id 18650446)¹ Bracamontes J.R. and Steinbach J.H. (2008)
23. Strong genetic evidence for a selective influence of GABA(A) receptors on a component of the bipolar disorder phenotype. (PubMed id 19078961)¹ Craddock N....O'Donovan M.C. (2008)
24. Benzodiazepine metabolism: an analytical perspective. (PubMed id 18855614)⁷ Mandrioli R....Raggi M.A. (2008)
25. Benzodiazepines in epilepsy: pharmacology and pharmac okinetics. (PubMed id 18384456)⁷ Riss J....Collins S. (2008)
26. Histamine action on vertebrate GABAA receptors: direct channel gating and potentiation of GABA responses. (PubMed id 18281286)¹ Saras A....Hatt H. (2008)
27. Do motor control genes contribute to interindividual variability in decreased movement in patients with pain? (PubMed id 17655760)¹ Mishra B.K....Max M.B. (2007)
28. How many drug targets are there? (PubMed id 17139284)⁷ Overington J.P....Hopkins A.L. (2006)
29. Investigation of autism and GABA receptor subunit genes in multiple ethnic groups. (PubMed id 16770606)¹ Collins A.L....Pericak-Vance M.A. (2006)
30. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)⁷ Imming P....Meyer A. (2006)
31. The polymorphism GABABR1 T1974C[rs29230] of the GABAB receptor gene is not associated with the diagnosis of alcoholism or alcohol withdrawal seizures. (PubMed id 16800828)¹ Kohnke M....Batra A. (2006)
32. [A mechanism for gamma-hydroxybutyrate (GHB) as a drug and a substance of abuse] (PubMed id 15745703)⁷ Maitre M....Andriamampandry C. (2005)
33. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
34. The brefeldin A-inhibited GDP/GTP exchange factor 2, a protein involved in vesicular trafficking, interacts with the beta subunits of the GABA receptors. (PubMed id 15198677)¹ Charych E.I....De Blas A.L. (2004)
35. GABAA receptor beta subunit mRNA expression in the human alcoholic brain. (PubMed id 15337300)¹ Buckley S.T. and Dodd P.R. (2004)
36. Identification of a residue in the gamma-aminobutyric acid type A receptor alpha subunit that differentially affects diazepam-sensit ive and -insensitive benzodiazepine site binding. (PubMed id 15009644)⁷ Derry J.M....Davies M. (2004)
37. The organochlorine pesticides gamma-hexachlorocyclohe xane (lindane), alpha-endosulfan and dieldrin differentially interact with GABA (A) and glycine-gated chloride channels in primary cultures of cerebellar granu le cells. (PubMed id 12614680)⁷ Vale C....SuA+ol C. (2003)
38. A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits. (PubMed id 12595241)¹ Brandon N.J....Moss S.J. (2003)
39. Chloride channels as tools for developing selective i nsecticides. (PubMed id 14635176)⁷ Bloomquist J.R. (2003)
40. Candidate genes for alcohol dependence: a review of genetic evidence from human studies. (PubMed id 12766633)⁴ Dick D.M. and Foroud T. (2003)
41. [Cardiotoxicity of lindane, a gamma isomer of hexachlorocyclohexane] (PubMed id 12645305)⁷ Sauviat M.P. and Pages N. (2002)
42. A new benzodiazepine pharmacology. (PubMed id 11752090)⁷ MAPhler H....Rudolph U. (2002)
43. Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus. (PubMed id 11891318)¹ Porjesz B....Begleiter H. (2002)
44. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
45. GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1. (PubMed id 11528422)¹ Bedford F.K....Moss S.J. (2001)
46. Unique phosphorylation mechanism of Gab1 using PI 3-kinase as an adaptor protein. (PubMed id 11606067)¹ Onishi-Haraikawa Y....Asano T. (2001)
47. Interaction between GABA(A) receptor beta subunits and the multifunctional protein gC1q-R. (PubMed id 11350968)¹ Schaerer M.T....Sigel E. (2001)
48. A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory. (PubMed id 11140838)¹ Comings D.E....MacMurray J.P. (2000)
49. Expression and distribution of GABAA receptor subtypes in human alcoholic cerebral cortex. (PubMed id 11085308)¹ Buckley S.T....Dodd P.R. (2000)
50. An initiator element mediates autologous downregulation of the human type A gamma -aminobutyric acid receptor beta 1 subunit gene. (PubMed id 10900018)¹ Russek S.J....Farb D.H. (2000)
51. The Protein Data Bank. (PubMed id 10592235)⁷ Berman H.M....Bourne P.E. (2000)
52. Theta, a novel gamma-aminobutyric acid type A receptor subunit. (PubMed id 10449790)¹ Bonnert T.P.... Whiting P.J. (1999)
53. Evolution of GABA(A) receptor diversity in the human genome. (PubMed id 10023064)¹ Russek S.J. (1999)
54. Role of GABA receptor complex in low dose lindane (HC H) induced neurotoxicity: neurobehavioural, neurochemical and electrophysiologi cal studies. (PubMed id 9530529)⁷ Anand M....Seth P.K. (1998)
55. Adjacent phosphorylation sites on GABAA receptor beta subunits determine regulation by cAMP-dependent protein kinase. (PubMed id 10195104)¹ McDonald B.J....Smart T.G. (1998)
56. A study of genetic association between manic-depressive illness and a highly polymorphic marker from the GABRbeta-1 gene. (PubMed id 9184321)⁴ Puertollano R....Fernandez-Piqueras J. (1997)
57. Neuronal ion channels as the target sites of insecticides. (PubMed id 8841090)⁷ Narahashi T. (1996)
58. Lindane blocks GABAA-mediated inhibition and modulate s pyramidal cell excitability in the rat hippocampal slice. (PubMed id 7566682)⁷ Joy R.M....Albertson T.E. (1995)
59. Drosophila GABA-gated chloride channel: modified [3H] EBOB binding site associated with Ala-->Ser or Gly mutants of Rdl subunit. (PubMed id 7885191)⁷ Cole L.M....Casida J.E. (1995)
60. Molecular determinants of recognition and activation at the cerebellar benzodiazepine receptor site. (PubMed id 7773620)⁷ Schove L.T....Loew G.H. (1994)
61. A selective fluorimetric method for the determination of some 1,4-benzodiazepine drugs containing a hydroxyl group at C-3. (PubMed id 7849137)⁷ Walash M.I....Hefnawy M.M. (1994)
62. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)¹ Maruyama K. and Sugano S. (1994)
63. Functional modulation of GABAA receptors by cAMP-dependent protein phosphorylation. (PubMed id 1323140)¹ Moss S.J....Huganir R.L. (1992)
64. Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the beta 1, gamma 2S, and gamma 2L subunits of the gamma-aminobutyric acid type A receptor. (PubMed id 1321150)¹ Moss S.J....Huganir R.L. (1992)
65. Genetic mapping of the beta 1 GABA receptor gene to human chromosome 4, using a tetranucleotide repeat polymorphism. (PubMed id 1652891)¹ Dean M....Goldman D. (1991)
66. Selective affinity of the benzodiazepines quazepam an d 2-oxo-quazepam for BZ1 binding site and demonstration of 3H-2-oxo-quazepam as a BZ1 selective radioligand. (PubMed id 2892106)⁷ Billard W....Barnett A. (1988)
67. Benzodiazepine receptor binding of triazolobenzodiaze pines in vivo: increased receptor number with low-dose alprazolam. (PubMed id 2889803)⁷ Miller L.G....Paul S.M. (1987)
68. Benzodiazepine receptors and their relationship to th e treatment of epilepsy. (PubMed id 3017690)⁷ Meldrum B.S. and Chapman A.G. (1986)
69. [Racemation of the benzodiazepines camazepam and keta zolam and receptor binding of enantiomers]. (PubMed id 2874815)⁷ Blaschke G....MA1ller W.E. (1986)
70. Autoradiographic demonstration of the selectivity of two 1-N-trifluoroethyl benzodiazepines for the BZD-1 receptors in the rat brain . (PubMed id 2867566)⁷ Wamsley J.K....Barnett A. (1985)
71. Benzodiazepines and their metabolites: relationship b etween binding affinity to the benzodiazepine receptor and pharmacological acti vity. (PubMed id 2857046)⁷ Nakatsuka I....Yoshitake A. (1985)
72. Selective affinity of 1-N-trifluoroethyl benzodiazepi nes for cerebellar type 1 receptor sites. (PubMed id 6738302)⁷ Iorio L.C....Billard W. (1984)
73. Determination of biological activity of adinazolam an d its metabolites. (PubMed id 6148400)⁷ Sethy V.H....Daniels E.G. (1984)
74. Pharmacological profile of the antidepressant adinazo lam, a triazolobenzodiazepine. (PubMed id 6320036)⁷ Lahti R.A....Hester J.B. (1983)
75. Pharmacological characterization of benzodiazepine re ceptors in the brain. (PubMed id 639854)⁷ Braestrup C. and Squires R.F. (1978)
76. Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. (PubMed id 16080114)⁹ Ma D.Q....Pericak-Vance M.A. (2005)

External Searches for GABRB1 gene

Genome Databases showing GABRB1 gene

Other Databases showing GABRB1 gene

Specialized Databases showing GABRB1 gene

Products
for GABRB1 gene