GABRA6 Gene
protein-coding GIFtS: 66
GCID: GC05P161045
|
|
gamma-aminobutyric acid (GABA) A receptor, alpha 6
| |
Aliases
for GABRA6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Gamma-Aminobutyric Acid (GABA) A Receptor, Alpha 61 2 | | GABA(A) Receptor Subunit Alpha-62 3 | | GABA Subunit A Receptor Alpha 62 | | GABA(A) Receptor, Alpha 62 | | Gamma-Aminobutyric Acid Receptor Subunit Alpha-62 |
Export aliases for GABRA6 gene to outside databasesPrevious GC identifers: GC05P161230 GC05P161620 GC05P161048 GC05P161093 GC05P156205 |
Summaries
for GABRA6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GABRA6:
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which areligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such asbenzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have beenidentified. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: GBRA6_HUMAN, Q16445Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by bindingto the GABA/benzodiazepine receptor and opening an integral chloride channel
 summary
for GABRA6: GABAA receptors are members of the cys-loop family of ligand-gated ion channels, responsible for mediating
the inhibitory effects of GABA alongside GABAB and GABAC receptors. They are pentameric proteins, consisting
of 5 subunits belonging to different families (alpha1-6, beta1-3, gamma1-3, delta, pi, epsilon, rho, theta).
The most abundant GABAA receptor in the mammalian brain consist of two copies each of alpha1 and beta2 with
a single gamma2 subunits. GABAA receptors contain an integral chloride channel, and have modulatory sites
for benzodiazepines, barbiturates, neurosteroids and ethanol.
Gene Wiki entry for GABRA6
|
Genomic Views
for GABRA6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GABRA6 gene promoter:
RP58 AML1a HSF1 (long) FOXO3 FOXD3 C/EBPalpha FOXO3b FOXL1 HSF1short FOXO3a
Other transcription factors
Search SABiosciences Chromatin IP Primers for GABRA6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GABRA6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q34 Ensembl cytogenetic band: 5q34 HGNC cytogenetic band: 5q34GABRA6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P161045: view genomic region
(about GC identifiers)
Start:
|
160,974,069 bp from pter |
End:
|
161,129,599 bp from pter |
Size:
|
155,531 bases |
Orientation:
|
plus strand |
|
Proteins
for GABRA6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GBRA6_HUMAN, Q16445 (See
protein sequence)Recommended Name: Gamma-aminobutyric acid receptor subunit alpha-6 precursor Size: 453 amino acids; 51024 Da
Subunit: Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha,beta, gamma, delta, and rho
Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane;Multi-pass membrane protein
Secondary accessions: A8K096 Q4VAV2Explore the universe of human proteins at neXtProt for GABRA6: NX_Q16445
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q16445
GABRA6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000802.2
ENSEMBL proteins: ENSP00000274545 ENSP00000430527 ENSP00000429943 ENSP00000430212 ENSP00000427989 Reactome Protein details: Q16445
Human Recombinant Protein Products:
Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13): About this table
GABRA6 for ontologies About GeneDecksing
GABRA6 Antibody Products:
Assay Products for GABRA6: |
Protein
Domains /
Families
for GABRA6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GABRA6 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q16445ProtoNet protein and cluster: Q16445 4 Blocks protein families: IPB001390 Gamma-aminobutyric-acid A receptor alpha subunit signature IPB005436 Gamma-aminobutyric-acid A receptor alpha 6 subunit signature IPB006028 Gamma-aminobutyric acid A (GABAA) receptor signature IPB006201 Neurotransmitter-gated ion-channel
UniProtKB/Swiss-Prot: GBRA6_HUMAN, Q16445Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5)subfamily. GABRA6 sub-subfamily |
Function
for GABRA6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GBRA6_HUMAN, Q16445Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by bindingto the GABA/benzodiazepine receptor and opening an integral chloride channel Genatlas biochemistry entry for GABRA6:gamma-aminobutyric acid (GABA) A receptor,ionotropic,alpha 6,subunit,component of a pentameric receptor mediatinginhibitory neurotransmission,expressed in the cerebellar granule cells and the related cells of cochlear nucleus
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GABRA6 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GABRA6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: GABRA6 (NM_000811) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GABRA6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GABRA6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABRA6 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004890 | GABA-A receptor activity |
IEA | -- | | GO:0005230 | extracellular ligand-gated ion channel activity |
IEA | -- | | GO:0005237 | inhibitory extracellular ligand-gated ion channel activity |
-- | -- | | GO:0005254 | chloride channel activity |
IEA | -- | | GO:0008144 | drug binding |
-- | -- |
GABRA6 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for GABRA6:
Animal Models:
Mouse knock-out Gabra6tm1Geh for GABRA6
5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Gabra6):
GABRA6 for phenotypes About GeneDecksing
|
Pathways & Interactions
for GABRA6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | GABA A receptor activation | | | 2 | Transmission across Chemical Synapses | | | 3 | Ion channel transport | | | 4 | Akt Signaling | | | 5 | Activation of GABAB receptors | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for GABRA6
1  R&D Systems Pathway for GABRA6
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GABRA6
1 Tocris Bioscience Pathway for GABRA6
5/8 
Reactome Pathways for GABRA6 (see all 8)
1 
Kegg Pathway (Kegg details for GABRA6):
GABRA6 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GABRA6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
5/11 Interacting proteins for GABRA6 (ENSP000002745454) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
GABRA6 for ontologies About GeneDecksing
|
Drugs & Compounds
for GABRA6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
GABRA6 for compounds About GeneDecksing
Compounds for GABRA6 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| Muscimol | Potent GABAA agonist | [2763-96-4] | | (+)-Bicuculline | Potent GABAA antagonist | [485-49-4] | | L-655,708 | Selective for alpha5-containing GABAA receptors | [130477-52-0] | | AA 29504 | Positive allosteric modulator of GABAA receptors | [945828-50-2] | | SR 95531 hydrobromide | Selective, competitive GABAA receptor antagonist | [104104-50-9] |
2 HMDB Compounds for GABRA6 About this table
10/32 DrugBank Compounds for GABRA6 (see all 32) About this table
1 Novoseek chemical compound relationship for GABRA6 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gaba |
59 |
2 |
8632757 (1), 12946574 (1) |
Search CenterWatch for drugs/clinical trials and news about GABRA6 / GBRA6
|
Transcripts
for GABRA6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GABRA6 gene: NM_000811.2 Unigene Cluster for GABRA6: Gamma-aminobutyric acid (GABA) A receptor, alpha 6 Hs.90791 [show with all ESTs]Unigene Representative Sequence: NM_0008119 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000522269 ENST00000518888 ENST00000274545 ENST00000523217(uc003lyu.2)
ENST00000524220 ENST00000520000 ENST00000517823 ENST00000523691 ENST00000521520(uc003lyv.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GABRA6 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GABRA6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GABRA6 (NM_000811) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GABRA6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GABRA6 |
Additional cDNA sequence: AK090735.1 AK289461.1 BC096241.3 BC096242.3 BC099640.3 BC099641.3 S81944.1 4 DOTS entries: DT.209578 DT.120819196 DT.95191076 DT.120819139 16 AceView cDNA sequences: F10732 BX488017 AW952267 CK003547 BX508021 F13129 BX488001 BX279910 AK090735 S81944 NM_000811 BG211331 BG220722 AA297014 AA297038 R38700
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for GABRA6 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|
|
| SP1: | | | - | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for GABRA6
|
Expression
for GABRA6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GABRA6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGGAGGCCT
About this image
See GABRA6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GABRA6
SOURCE GeneReport for Unigene cluster: Hs.90791
SABiosciences Expression via Pathway-Focused PCR Arrays including GABRA6:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GABRA6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GABRA6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GABRA6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GABRA6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABRA6 |
Orthologs
for GABRA6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for GABRA6 gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
GABRA61 |
gamma-aminobutyric acid (GABA) A receptor, alpha 6 |
79.49(n)
84.34(a) |
|
395931 NM_205058.1 NP_990389.1 |
lizard
(Anolis carolinensis) |
Reptilia |
GABRA66 |
-- |
81(a) |
1 ↔ 1 |
1(106696044-106741581) |
zebrafish
(Danio rerio) |
Actinopterygii |
BC059508.12 |
-- |
74.21(n) |
|
393704 BC059508.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Grd3 |
glycine-gated ion channel |
52(a)
(best of 2) |
|
75A4 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
F11H8.23 |
gamma-aminobutyric acid receptor |
35(a) |
|
III(7080998-7091156) -- |
ENSEMBL Gene Tree for GABRA6 (if available)
TreeFam Gene Tree for GABRA6 (if available) |
Paralogs
for GABRA6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GABRA6 gene
- GABRG22 GABRE2 GABRA22 GABRA42 GABRG12 GABRG32 GABRA52 GABRA32
- GABRA12
18/25 SIMAP similar genes for GABRA6 using alignment to 5 protein entries: GBRA6_HUMAN (see all proteins)
(see all similar genes):GABRA3 GABRA5 GABRA2 GABRA4 GABRA1 GABRG3
GABRG2 GABRE GABRG1 GLRA3 GLRA4 GABRB3
GABRP GABRB1 GABRQ GLRA2 GABRR2 GABRB2
GABRA6 for paralogs About GeneDecksing
|
Genomic Variants
for GABRA6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GABRA6 (160974069 - 161129599 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for GABRA6
1 CNV: 47996
Human Gene Mutation Database (HGMD): GABRA6
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GABRA6 |
|
Disorders
/ Diseases
for GABRA6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GABRA6 for disorders About GeneDecksing
OMIM gene information: 137143
OMIM disorders: --
12  diseases for GABRA6: About MalaCardsheroin dependence canavan disease anorexia nervosa schizoaffective disorder
alcohol dependence panic disorder mood disorder bipolar disorder
alcoholism obesity schizophrenia neuronitis
2 diseases from the University of Copenhagen DISEASES database for GABRA6:Antisocial personality disorder Alcohol dependence Genetic Association Database (GAD): GABRA6
Human Genome Epidemiology (HuGE) Navigator: GABRA6 (28 documents)
Export disorders for GABRA6 gene to outside databases
|
Publications
for GABRA6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GABRA6 gene, integrated from 9 sources (see all 57):
(articles sorted by number of sources associating them with GABRA6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- GABRA6 gene polymorphism and an attenuated stress response. (PubMed id 15197399)1, 4, 9 Uhart M....Wand G.S. (2004)
- Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors. (PubMed id 8632757)1, 2, 9 Hadingham K.L.... Whiting P.J. (1996)
- Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia. (PubMed id 16172613)1, 4 Petryshen T.L....Sklar P. (2005)
- Association studies of neurotransmitter gene polymorphisms in alcoholic Caucasians. (PubMed id 15542698)1, 4 Foley P.F....Dodd P.R. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism. (PubMed id 14744464)1, 4 Sen S....Burmeister M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Association between a variant at the GABA(A)alpha6 receptor subunit gene, abdominal obesity, and cortisol secretion. (PubMed id 12079890)1, 4 Rosmond R....Bjorntorp P. (2002)
- Association of the gamma-aminobutyric acid A receptor gene cluster with alcohol dependence in Taiwanese Han. (PubMed id 12232773)1, 4 Chang Y.T....Cheng A.T. (2002)
- Allelic variants in the GABA(A)alpha6 receptor subunit gene (GABRA6) is associated with abdominal obesity and cortisol secretion. (PubMed id 12080446)1, 4 Rosmond R....Bjorntorp P. (2002)
|
External Searches for GABRA6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GABRA6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GABRA6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GABRA6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GABRA6 | Pharmacogenomics, SNPs, Pathways | | Protein Spotlight | http://web.expasy.org/spotlight/back_issues/sptlt056.shtml |
|
| | |
About This Section
| Patent Information for GABRA6 gene:
Search GeneIP for patents involving GABRA6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GABRA6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for GABRA6 | | OriGene shRNA RFP for GABRA6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GABRA6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GABRA6 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GABRA6 | | OriGene 3'-UTR Clone for GABRA6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GABRA6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GABRA6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GABRA6 | | OriGene Custom Protein Services for GABRA6 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GABRA6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GABRA6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GABRA6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GABRA6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GABRA6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GABRA6 |
| |
 |  |  |  | |
| | | |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABRA6 |
|  |  |  | | | | ThermoFisher Antibodies for GABRA6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GABRA6 |
|
|
|
|
