Aliases for GABRA6 Gene
External Ids for GABRA6 Gene
Previous GeneCards Identifiers for GABRA6 Gene
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for GABRA6 Gene
GABRA6 (Gamma-Aminobutyric Acid Type A Receptor Alpha6 Subunit) is a Protein Coding gene. Diseases associated with GABRA6 include Benign Familial Neonatal Epilepsy and Childhood Absence Epilepsy. Among its related pathways are Transmission across Chemical Synapses and GABAergic synapse. Gene Ontology (GO) annotations related to this gene include chloride channel activity and GABA-A receptor activity. An important paralog of this gene is GABRA4.
UniProtKB/Swiss-Prot for GABRA6 Gene
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
GABAA receptors are members of the Cys-loop family of ligand-gated ion channels and, along with GABAB receptors, are responsible for mediating the inhibitory effects of GABA. They are pentameric proteins, consisting of five subunits belonging to different families.