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GABRA6 Gene

protein-coding GIFtS: 69

GC05P161045

gamma-aminobutyric acid (GABA) A receptor, alpha 6
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC116903 ^²
MGC116904 ^²

Descriptions
GABA subunit A receptor alpha 6 ^²
GABA(A) receptor subunit alpha-6 ^³
gamma-aminobutyric acid (GABA) A receptor, alpha 6 ^²
gamma-aminobutyric acid A receptor, alpha 6 ^²

External Ids
HGNC: 4080¹
Entrez Gene: 2559²
UniProtKB: Q16445³
Ensembl: ENSG00000145863⁷

Search outside databases for aliases for GABRA6 gene

Previous GC identifers: GC05P161230 GC05P161620 GC05P161048 GC05P161093

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GABRA6:

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A

receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be

modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct

subunits of GABA-A receptors have been identified. [provided by RefSeq]

UniProtKB/Swiss-Prot: GBRA6_HUMAN, Q16445

Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal

inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

Gene Wiki entry for GABRA6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GABRA6 gene

Entrez Gene cytogenetic band: 5q34 Ensembl cytogenetic band: 5q34 HGNC cytogenetic band: 5q34

GABRA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P161045: (about GC identifiers)

Start:	161,045,236 bp from pter
End:	161,062,176 bp from pter
Size:	16,941 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000005.8 NT_023133.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GBRA6_HUMAN, Q16445 (See protein sequence)

Recommended Name: Gamma-aminobutyric acid receptor subunit alpha-6 precursor

Size: 453 amino acids; 51024 Da

Subunit: Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A)

receptor chains: alpha, beta, gamma, delta, and rho

Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane

protein. Cell membrane; Multi-pass membrane protein

Secondary accessions: Q4VAV2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000802.2

ENSEMBL proteins:

ENSP00000274545

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GABA A Receptor alpha 6)
	Human Recombinant Proteins from Abnova (GABRA6)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	8632757
GO:0030054	cell junction	IEA	--
GO:0045202	synapse	IEA	--
GO:0045211	postsynaptic membrane	IEA	--

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Antibodies for GABRA6:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of GABRA6
	Sigma-Aldrich Antibodies for GABRA6
	R&D Systems Antibodies for GABRA6 (GABA-A-R alpha 6)
	Antibodies from Abcam (GABA A Receptor alpha 6), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for GABRA6

Assays for GABRA6:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q16445

ProtoNet protein and cluster: Q16445

4 Blocks protein families:

IPB001390 Gamma-aminobutyric-acid A receptor alpha subunit signature

IPB005436 Gamma-aminobutyric-acid A receptor alpha 6 subunit signature

IPB006028 Gamma-aminobutyric acid A (GABAA) receptor signature

IPB006201 Neurotransmitter-gated ion-channel

UniProtKB/Swiss-Prot: GBRA6_HUMAN, Q16445

Similarity: Belongs to the ligand-gated ionic channel (TC 1.A.9) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GABRA6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GABRA6)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000811

Applied Biosystems Silencer® siRNAs for GABRA6

Sigma-Aldrich siRNA and siRNA Panels for GABRA6

Sigma-Aldrich shRNA for GABRA6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GABRA6
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000811
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000811
untagged cDNA clones in CMV expression vector (see all 2): NM_000811

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000811

UniProtKB/Swiss-Prot: GBRA6_HUMAN, Q16445

Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal

inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

Genatlas biochemistry entry for GABRA6:

gamma-aminobutyric acid (GABA) A receptor,ionotropic,alpha 6,subunit,component of a pentameric

receptor mediating inhibitory neurotransmission,expressed in the cerebellar granule cells and the

related cells of cochlear nucleus

5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Gabra6):

behavior/neurological

hearing/vestibular/ear

homeostasis/metabolism

nervous system

normal

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004890	GABA-A receptor activity	IEA	--
GO:0005216	ion channel activity	IEA	--
GO:0005230	extracellular ligand-gated ion channel activity	IEA	--
GO:0005254	chloride channel activity	IEA	--
GO:0008503	benzodiazepine receptor activity	TAS	8632757

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for GABRA6 (Your Favorite Gene powered by Ingenuity)

GABA Receptor Signaling

GeneDecks GABRA6 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for GABRA6

5/21 Interacting proteins for GABRA6 (ENSP00000274545³) via UniProtKB, MINT, and/or STRING (see all 21 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NFIA	ENSP00000360233³	STRING (score=.916)
NFIC	ENSP00000342859³	STRING (score=.885)
GABRB2	ENSP00000274547³	STRING (score=.826)
GABRP	ENSP00000265294³	STRING (score=.824)
GABRD	ENSP00000367848³	STRING (score=.823)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0006821	chloride transport	IEA	--
GO:0007165	signal transduction	TAS	8632757
GO:0007214	gamma-aminobutyric acid signaling pathway	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for GABRA6

Sigma-Aldrich Small Molecules for GABRA6:

Antagonist Allosteric Modulator Agonist Inhibitor Ligand

Compounds for GABRA6 available from Tocris Bioscience

Compound	Action	CAS number
Muscimol	Potent GABAA agonist	[2763-96-4]
(+)-Bicuculline	Potent GABAA antagonist	[485-49-4]
Indiplon	Subtype-selective GABAA receptor positive allosteric modulator	[325715-02-4]
L-655,708	Selective for alpha5-containing GABAA receptors	[130477-52-0]
SR 95531 hydrobromide	Selective, competitive GABAA receptor antagonist	[104104-50-9]

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1 PharmGKB drug compound relationship for GABRA6 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
diazepam	CO GN	10484961

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GABRA6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GABRA6)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000811

Sigma-Aldrich siRNA and siRNA Panels for GABRA6

Sigma-Aldrich shRNA for GABRA6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000811

REFSEQ mRNAs for GABRA6 gene:

NM_000811.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000811

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000811
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000811
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000811

Additional cDNA sequence:

AK090735.1 AK289461.1 BC096241.3 BC096242.3 BC099640.3 BC099641.3 S81944.1

4 DOTS entries:

DT.209578 DT.120819196 DT.95191076 DT.120819139

16 AceView cDNA sequences:

BX488017 F10732 S81944 F13129 BX508021 BX279910 AW952267 CK003547

NM_000811 AK090735 BX488001 BG211331 BG220722 AA297014 AA297038 R38700

highest scoring ESTs for GABRA6:

S81944 AA297014 AA297038 AK090735 AW952267 BG198853 BG220722 BX279910 F13129 BC096241

Unigene Cluster for GABRA6:

Gamma-aminobutyric acid (GABA) A receptor, alpha 6

Hs.90791 [show with all ESTs]

Unigene Representative Sequence: NM_000811

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for GABRA6

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9a	·	9b
SP1:			-												-		-
SP2:
SP3:															-
SP4:

About this scheme

ECgene alternative splicing isoforms for GABRA6

1 Ensembl transcript including schematic representation:

ENST00000274545

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GABRA6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GABRA6

¹ / ² / ³

4 probe-sets matching GABRA6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34025_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.80	S81944	1.00	1.00	1.00	1
47274_r_at²^{, 3}	U95-B	1	0.75	1.00	0.97	1.58	R38700	0.60	1.00	0.82	1
207182_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000811	0.60	1.00	0.82	1
207182_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks GABRA6 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTGGAGGCCT

SOURCE GeneReport for Unigene cluster: Hs.90791
Expression variation in blood from EXPOLDB for GABRA6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GABRA6 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GABRA6¹	--	gamma-aminobutyric acid (GABA) A receptor, alpha 6	92.64(n) 96.47(a)	489145 XM_546263.2 XP_546263.2
chimpanzee (Pan troglodytes)	GABRA6¹	--	gamma-aminobutyric acid (GABA) A receptor, alpha 6	98.97(n) 99.34(a)	471725 XM_001144260.1 XP_001144260.1
cow (Bos taurus)	GABRA6¹	--	gamma-aminobutyric acid (GABA) A receptor, alpha 6	91.32(n) 94.92(a)	539194 XM_585538.2 XP_585538.2
rat (Rattus norvegicus)	Gabra6¹	--	gamma-aminobutyric acid (GABA) A receptor, alpha 6	86.12(n) 91.98(a)	29708 NM_021841.1 NP_068613.1
mouse (Mus musculus)	Gabra6^{1, 5}	11 (23.00 cM)⁵	gamma-aminobutyric acid (GABA) A receptor, subunit more⁵ gamma-aminobutyric acid (GABA-A) receptor, subunit more¹	86.38(n)¹ 91.42(a)¹	14399¹ NM_008068.1¹ NP_032094.1¹ AF256197⁵ AF256198⁵ (see all 16)

About this table Species with no ortholog for GABRA6

ENSEMBL Gene Tree for GABRA6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GABRA6 gene

GABRA4² GABRA3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/100 NCBI SNPs in GABRA6 are shown (see all 100 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 67)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1992647^1,2	A,C,F,H	161043752(-)	`TACCAT/CTCATC`	1	--	ng5¹		6		EU EA WA NA	594
	rs1992646^1,2	A,C,F,H	161043839(-)	`ACAACT/GTTTTT`	1	--	ng5¹		8		EU EA WA	838
	rs6883758^1,2	A,C,F,H	161062623(+)	`CTACTC/GTCTTA`	1	--	ng3¹		4		EU EA WA	420
	rs3219151^1,2	A,C,F,H	161061492(+)	`GCTTCC/TGTAAG`	1	--	ut3¹ ese³		7		NA EU EA WA	562
	rs4921195^1,2	A,C,F,H	161044166(+)	`TGTTAT/CGGCTG`	1	--	ng5¹		8		EU EA WA	838
	rs3811995^1,2	A,C,F,H	161045271(-)	`GGACAG/ATGCAT`	1	--	ut5¹		4		EU EA WA	412
	rs3811993^1,2	C,F,H	161049250(-)	`TCCACG/ATATAT`	1	M/T	mis¹ ese³		8		EU EA WA	812
	rs6865042^1,2	A,C,F	161062414(+)	`TTTCCA/GTTACT`	1	--	ng3¹		3		NA	142
	rs34907804^1,2	C,F	161061205(-)	`TGGGGG/ATGTGA`	1	S/P	mis¹		5		NA EU EA WA	494
--	rs9313892^1,2	C	161043570(+)	`actagA/Gtgatg`	1	--	ng5¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for GABRA6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 137143

Genetic Association Database: GABRA6
Human Genome Epidemiology Navigator: GABRA6 (17 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/33 PubMed articles for GABRA6 gene (see all 33 ):

GABRA6 gene polymorphism and an attenuated stress response. (PubMed id 15197399)^{1, 3, 6} Uhart M....Wand G.S. (2004)
Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors. (PubMed id 8632757)^{1, 3, 4} Hadingham K.L.... Whiting P.J. (1996)
Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia. (PubMed id 16172613)^{3, 6} Petryshen T.L....Sklar P. (2005)
Association studies of neurotransmitter gene polymorphisms in alcoholic Caucasians. (PubMed id 15542698)^{3, 6} Foley P.F....Dodd P.R. (2004)
Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism. (PubMed id 14744464)^{3, 6} Sen S....Burmeister M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Association between a variant at the GABA(A)alpha6 receptor subunit gene, abdominal obesity, and cortisol secretion. (PubMed id 12079890)^{3, 6} Rosmond R....Bjorntorp P. (2002)
Association of the gamma-aminobutyric acid A receptor gene cluster with alcohol dependence in Taiwanese Han. (PubMed id 12232773)^{3, 6} Chang Y.T....Cheng A.T. (2002)
Allelic variants in the GABA(A)alpha6 receptor subunit gene (GABRA6) is associated with abdominal obesity and cortisol secretion. (PubMed id 12080446)^{3, 6} Rosmond R....Bjorntorp P. (2002)
Further evidence for clustering of human GABAA receptor subunit genes: localization of the alpha 6-subunit gene (GABRA6) to distal chromosome 5q by linkage analysis. (PubMed id 8020978)^{2, 3} Hicks A.A....Darlison M.G. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2559	HGNC: 4080	AceView: GABRA6	Ensembl:ENSG00000145863	euGenes: HUgn2559
ECgene: GABRA6	H-InvDB: GABRA6

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Protein Spotlight	http://www.expasy.org/spotlight/back_issues/sptlt056.shtml

Licensable Technologies for GABRA6
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for GABRA6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GABRA6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GABRA6		Antibodies for GABRA6
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GABRA6		Small molecules for GABRA6
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Tocris compounds for GABRA6

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	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for GABRA6

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GABRA6 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for GABRA6

Summaries
for GABRA6

Genomic Location
for GABRA6

Proteins
for GABRA6

Protein Domains/
Families
for GABRA6

Gene Function
for GABRA6

Pathways & Interactions
for GABRA6

Drugs & Compounds
for GABRA6

Transcripts
for GABRA6

Expression
for GABRA6

Orthologs
for GABRA6

Paralogs
for GABRA6

SNPs/Variants
for GABRA6

Disorders & Mutations
for GABRA6

Medical News
for GABRA6

Publications
for GABRA6

Search for GABRA6

Genome Databases showing GABRA6

Other Databases showing GABRA6

Specialized Databases showing GABRA6

Licensable Technologies
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Services
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GABRA6 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor GABRA6

Summariesfor GABRA6

Genomic Locationfor GABRA6

Proteinsfor GABRA6

Protein Domains/Familiesfor GABRA6

Gene Functionfor GABRA6

Pathways & Interactionsfor GABRA6

Drugs & Compoundsfor GABRA6

Transcriptsfor GABRA6

Expression for GABRA6

Orthologsfor GABRA6

Paralogsfor GABRA6

SNPs/Variantsfor GABRA6

Disorders & Mutationsfor GABRA6

Medical Newsfor GABRA6

Publicationsfor GABRA6

Search for GABRA6

Genome Databases showing GABRA6

Other Databases showing GABRA6

Specialized Databases showing GABRA6

Licensable Technologiesfor GABRA6

Servicesfor GABRA6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GABRA6

Summaries
for GABRA6

Genomic Location
for GABRA6

Proteins
for GABRA6

Protein Domains/
Families
for GABRA6

Gene Function
for GABRA6

Pathways & Interactions
for GABRA6

Drugs & Compounds
for GABRA6

Transcripts
for GABRA6

Expression
for GABRA6

Orthologs
for GABRA6

Paralogs
for GABRA6

SNPs/Variants
for GABRA6

Disorders & Mutations
for GABRA6

Medical News
for GABRA6

Publications
for GABRA6

Licensable Technologies
for GABRA6

Services
for GABRA6