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GABRA5 Gene

protein-coding GIFtS: 66

GC15P024663

gamma-aminobutyric acid (GABA) A receptor, alpha 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
MGC138184 ^²

Descriptions
GABA(A) receptor subunit alpha-5 ^³
gamma-aminobutyric acid (GABA) A receptor, alpha 5 ^²
gamma-aminobutyric acid A receptor, alpha 5 ^¹

External Ids
HGNC: 4079¹
Entrez Gene: 2558²
UniProtKB: P31644³
Ensembl: ENSG00000186297⁷

Search outside databases for aliases for GABRA5 gene

Previous GC identifers: GC15P023334 GC15P020091 GC15P024593 GC15P024722

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for GABRA5:

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A

receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be

modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct

subunits of GABA-A receptors have been identified. Transcript variants utilizing three different

alternative non-coding first exons have been described. [provided by RefSeq]

UniProtKB/Swiss-Prot: GBRA5_HUMAN, P31644

Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal

inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

Gene Wiki entry for GABRA5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GABRA5 gene

Entrez Gene cytogenetic band: 15q11.2-q12 Ensembl cytogenetic band: 15q12 HGNC cytogenetic band: 15q11-q13

GABRA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P024663: (about GC identifiers)

Start:	24,663,151 bp from pter
End:	24,777,095 bp from pter
Size:	113,945 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000015.8 NT_026446.13 NT_078095.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GBRA5_HUMAN, P31644 (See protein sequence)

Recommended Name: Gamma-aminobutyric acid receptor subunit alpha-5 precursor

Size: 462 amino acids; 52146 Da

Subunit: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma,

delta, and rho

Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane

protein. Cell membrane; Multi-pass membrane protein

Secondary accessions: A8K338 Q14DC2 Q53XL6 Q9NYT3 Q9NYT4 Q9NYT5

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000801.1

ENSEMBL proteins:

ENSP00000347557 ENSP00000335592 ENSP00000382953

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GABA A Receptor alpha 5)
	Human Recombinant Proteins from Abnova (GABRA5)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	1321750
GO:0030054	cell junction	IEA	--
GO:0045202	synapse	IEA	--
GO:0045211	postsynaptic membrane	IEA	--

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Antibodies for GABRA5:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of GABRA5
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for GABRA5 (GABA-A-R alpha 5)
	Antibodies from Abcam (GABA A Receptor alpha 5), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for GABRA5

Assays for GABRA5:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P31644

ProtoNet protein and cluster: P31644

4 Blocks protein families:

IPB001390 Gamma-aminobutyric-acid A receptor alpha subunit signature

IPB005435 Gamma-aminobutyric-acid A receptor alpha 5 subunit signature

IPB006028 Gamma-aminobutyric acid A (GABAA) receptor signature

IPB006201 Neurotransmitter-gated ion-channel

UniProtKB/Swiss-Prot: GBRA5_HUMAN, P31644

Similarity: Belongs to the ligand-gated ionic channel (TC 1.A.9) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GABRA5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GABRA5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000810

Applied Biosystems Silencer® siRNAs for GABRA5

Sigma-Aldrich siRNA and siRNA Panels for GABRA5

Sigma-Aldrich shRNA for GABRA5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000810
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000810
untagged cDNA clone in CMV expression vector: NM_000810

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000810

UniProtKB/Swiss-Prot: GBRA5_HUMAN, P31644

Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal

inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

Genatlas biochemistry entry for GABRA5:

gamma-aminobutyric acid (GABA) A receptor,ionotropic,alpha 5,mainly expressed in the brain,with

three isoforms,region specific,may be involved in the susceptibility to bipolar affective disorder

(? MAFD10),subunit,component of a pentameric receptor mediating inhibitory neurotransmission

5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Gabra5):

behavior/neurological

hearing/vestibular/ear

homeostasis/metabolism

nervous system

no phenotypic analysis

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004890	GABA-A receptor activity	IEA	--
GO:0005215	transporter activity	TAS	1321750
GO:0005216	ion channel activity	IEA	--
GO:0005230	extracellular ligand-gated ion channel activity	IEA	--
GO:0005254	chloride channel activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for GABRA5 (Your Favorite Gene powered by Ingenuity)

GABA Receptor Signaling

GeneDecks GABRA5 for the pathways selected above

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5/22 Interacting proteins for GABRA5 (ENSP00000335592³) via UniProtKB, MINT, and/or STRING (see all 22 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SNRPN	ENSP00000375105³	STRING (score=.868)
UBE3A	ENSP00000232165³	STRING (score=.857)
OCA2	ENSP00000346659³	STRING (score=.827)
GABRB3	ENSP00000372479³	STRING (score=.825)
GABRR1	ENSP00000358463³	STRING (score=.822)

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001662	behavioral fear response	IEA	--
GO:0006811	ion transport	IEA	--
GO:0006821	chloride transport	IEA	--
GO:0007165	signal transduction	TAS	1321750
GO:0007214	gamma-aminobutyric acid signaling pathway	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for GABRA5

Sigma-Aldrich Small Molecules for GABRA5:

Antagonist Allosteric Modulator Agonist Inhibitor Ligand

Compounds for GABRA5 available from Tocris Bioscience

Compound	Action	CAS number
Muscimol	Potent GABAA agonist	[2763-96-4]
(+)-Bicuculline	Potent GABAA antagonist	[485-49-4]
Indiplon	Subtype-selective GABAA receptor positive allosteric modulator	[325715-02-4]
L-655,708	Selective for alpha5-containing GABAA receptors	[130477-52-0]
SR 95531 hydrobromide	Selective, competitive GABAA receptor antagonist	[104104-50-9]

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GABRA5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GABRA5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000810

Sigma-Aldrich siRNA and siRNA Panels for GABRA5

Sigma-Aldrich shRNA for GABRA5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000810

REFSEQ mRNAs for GABRA5 gene:

NM_000810.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000810

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000810
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000810
                                 untagged cDNA clone in CMV expression vector: NM_000810

Additional cDNA sequence:

AK290453.1 AK294303.1 AK303742.1 BC111979.1 BC113422.1 BT009830.1 L08485.1

3 DOTS entries:

DT.108991 DT.91659917 DT.121034570

22 AceView cDNA sequences:

BM676770 AL119253 F03181 BM719912 AK124673 BU738949 AK126891 AL035783

BI552302 F07441 F06915 F03669 BF966961 F07440 AI807646 L08485

BC011403 BT009830 NM_000810 R35346 R49008 T28792

highest scoring ESTs for GABRA5:

L08485 BT009830 AI807646 AL035783 AL119253 BF966961 BI552302 BM676770 BM719912 BU738949

Unigene Cluster for GABRA5:

Gamma-aminobutyric acid (GABA) A receptor, alpha 5

Hs.612087 [show with all ESTs]

Unigene Representative Sequence: NM_000810

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for GABRA5 (see all 6 )

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	·	8c	^	9a	·	9b	^	10	^	11	^	12	^	13
SP1:			-		-		-		-
SP2:							-		-
SP3:									-										-		-		-		-
SP4:									-
SP5:									-												-		-		-		-		-

About this scheme

ECgene alternative splicing isoforms for GABRA5

3 Ensembl transcripts including schematic representations:

ENST00000355395 ENST00000335625 ENST00000400081

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GABRA5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GABRA5

¹ / ² / ³

7 probe-sets matching GABRA5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39321_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	L08485	1.00	0.90	0.95	1
215531_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF966183	0.40	0.67	0.55	1
206456_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000810	0.60	1.00	0.82	1
217280_x_at²	U133-A	1	0.91	1.00	--	--	--	--	--	--	--
215531_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206456_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217280_x_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

GeneDecks GABRA5 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.612087
Expression variation in blood from EXPOLDB for GABRA5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GABRA5 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GABRA5¹	--	gamma-aminobutyric acid (GABA) A receptor, alpha 5	91.63(n) 96.75(a)	488688 XM_545805.2 XP_545805.2
cow (Bos taurus)	GABRA5¹	--	gamma-aminobutyric acid (GABA) A receptor, alpha 5	90.02(n) 95.23(a)	523515 NM_001075844.1 NP_001069312.1
rat (Rattus norvegicus)	Gabra5¹	--	gamma-aminobutyric acid (GABA) A receptor, alpha 5	87.3(n) 95.02(a)	29707 NM_017295.1 NP_058991.1
mouse (Mus musculus)	Gabra5^{1, 5}	7 (28.50 cM)⁵	gamma-aminobutyric acid (GABA) A receptor, subunit more⁵ gamma-aminobutyric acid (GABA-A) receptor, subunit more¹	87.73(n)¹ 95.45(a)¹	110886¹ NM_176942.3¹ NP_795916.1¹ AF090374⁵ AF540386⁵ (see all 10)
chicken (Gallus gallus)	GABRA5¹	--	gamma-aminobutyric acid (GABA) A receptor, alpha 5	79.87(n) 89.39(a)	418684 XM_416880.2 XP_416880.2

About this table Species with no ortholog for GABRA5

ENSEMBL Gene Tree for GABRA5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GABRA5 gene

GABRA2² GABRA1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/301 NCBI SNPs in GABRA5 are shown (see all 301 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 55)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs6606854^1,2	A,C,F,H	24741942(+)	`agaatC/Tcctca`	1	--	ng5¹		15		EU EA NA WA	1354
--	rs25410^1,2	A,C,F	24663255(+)	`CGGCCA/GAGGGC`	1	--	ut5¹ ese³		1		NA	26
--	rs25411^1,2	A,C,F	24663263(+)	`GGCGCA/GTTTGC`	1	--	ut5¹		1		NA	26
--	rs8036439^1,2	A	24663219(+)	`AGCCGC/GGGGCC`	1	--	ut5¹ ese³		0	--	--	--	--
	rs140685^1,2	C,F,H	24771205(+)	`ATAGCC/TGTGTG`	1	A/A	syn¹ ese³		21		NA MN EA EU WA	2004
	rs140682^1,2	C,F	24765103(+)	`GTCGTC/TTACGT`	1	V/V	syn¹		7		NA MN EA	1934
--	rs2229942^1,2	F	24775871(+)	`TTTACA/GACTGG`	1	T/T	syn¹ ese³		8		MN EU EA WA NA	596
	rs140683^1,2	A,C,F,H,O	24771081(+)	`GTTTTT/ACACTC`	1	--	int¹		15		NA MN EA EU WA	1584
	rs12439279^1,2	A,C,F,H	24766727(+)	`GTCTCC/TGACAT`	1	--	int¹		7		NA EU EA WA	562
	rs1864793^1,2	C,F,H,O	24766335(-)	`AAATAG/AGAGTA`	1	--	int¹		14		NA EA EU WA	1230

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HapMap Linkage Disequilibrium images for GABRA5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 137142

5 Novoseek disease relationships for GABRA5 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
angelman syndrome	83.15	1	11543639 (1)
childhood absence epilepsy	75.16	1	15498372 (1)
autistic	61.04	1	12092907 (1)
prader-willi syndrome	57.49	1	8388764 (1)
bipolar disorder	42.21	1	15882799 (1)

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Genetic Association Database: GABRA5
Human Genome Epidemiology Navigator: GABRA5 (14 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/43 PubMed articles for GABRA5 gene (see all 43 ):

Cloning and expression of a cDNA encoding the human GABA-A receptor alpha 5 subunit. (PubMed id 1321750)^{2, 3, 4} Wingrove P....Whiting P. (1992)
Human gamma-aminobutyric acid-type A receptor alpha5 subunit gene (GABRA5): characterization and structural organization of the 5' flanking region. (PubMed id 9205108)^{1, 3, 4} Kim Y.... Lalande M. (1997)
The GABA type A receptor alpha5 subunit gene is associated with bipolar I disorder. (PubMed id 15882799)^{1, 3, 6} Otani K....Kuroda S. (2005)
FISH ordering of reference markers and of the gene for the alpha 5 subunit of the gamma-aminobutyric acid receptor (GABRA5) within the Angelman and Prader-Willi syndrome chromosomal regions. (PubMed id 8388764)^{1, 3, 4} Knoll J.H.... Lalande M. (1993)
Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. (PubMed id 16080114)^{3, 6} Ma D.Q....Pericak-Vance M.A. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
[Case-control study and transmission/disequilibrium test of childhood absence epilepsy] (PubMed id 12048673)^{3, 6} Lu J....Wu X. (2002)
Association between GABA-A receptor alpha 5 subunit gene locus and schizophrenia of a later age of onset. (PubMed id 11287792)^{3, 6} Papadimitriou G....Stefanis C. (2001)
GABA-A receptor beta3 and alpha5 subunit gene cluster on chromosome 15q11-q13 and bipolar disorder: a genetic association study. (PubMed id 11378843)^{3, 6} Papadimitriou G.N....Stefanis C.N. (2001)
Structure and organization of GABRB3 and GABRA5. (PubMed id 9126483)^{1, 3} Glatt K....Lalande M. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2558	HGNC: 4079	AceView: GABRA5	Ensembl:ENSG00000186297	euGenes: HUgn2558
ECgene: GABRA5	H-InvDB: GABRA5

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
Protein Spotlight	http://www.expasy.org/spotlight/back_issues/sptlt056.shtml

Licensable Technologies for GABRA5
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for GABRA5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GABRA5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GABRA5		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GABRA5		Small molecules for GABRA5
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Tocris compounds for GABRA5

	Drugs for GABRA5
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

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GABRA5 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for GABRA5

Summaries
for GABRA5

Genomic Location
for GABRA5

Proteins
for GABRA5

Protein Domains/
Families
for GABRA5

Gene Function
for GABRA5

Pathways & Interactions
for GABRA5

Drugs & Compounds
for GABRA5

Transcripts
for GABRA5

Expression
for GABRA5

Orthologs
for GABRA5

Paralogs
for GABRA5

SNPs/Variants
for GABRA5

Disorders & Mutations
for GABRA5

Medical News
for GABRA5

Publications
for GABRA5

Search for GABRA5

Genome Databases showing GABRA5

Other Databases showing GABRA5

Specialized Databases showing GABRA5

Licensable Technologies
for GABRA5

Services
for GABRA5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GABRA5 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor GABRA5

Summariesfor GABRA5

Genomic Locationfor GABRA5

Proteinsfor GABRA5

Protein Domains/Familiesfor GABRA5

Gene Functionfor GABRA5

Pathways & Interactionsfor GABRA5

Drugs & Compoundsfor GABRA5

Transcriptsfor GABRA5

Expression for GABRA5

Orthologsfor GABRA5

Paralogsfor GABRA5

SNPs/Variantsfor GABRA5

Disorders & Mutationsfor GABRA5

Medical Newsfor GABRA5

Publicationsfor GABRA5

Search for GABRA5

Genome Databases showing GABRA5

Other Databases showing GABRA5

Specialized Databases showing GABRA5

Licensable Technologiesfor GABRA5

Servicesfor GABRA5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GABRA5

Summaries
for GABRA5

Genomic Location
for GABRA5

Proteins
for GABRA5

Protein Domains/
Families
for GABRA5

Gene Function
for GABRA5

Pathways & Interactions
for GABRA5

Drugs & Compounds
for GABRA5

Transcripts
for GABRA5

Expression
for GABRA5

Orthologs
for GABRA5

Paralogs
for GABRA5

SNPs/Variants
for GABRA5

Disorders & Mutations
for GABRA5

Medical News
for GABRA5

Publications
for GABRA5

Licensable Technologies
for GABRA5

Services
for GABRA5