Aliases for GABRA5 Gene
External Ids for GABRA5 Gene
Previous GeneCards Identifiers for GABRA5 Gene
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for GABRA5 Gene
GABRA5 (Gamma-Aminobutyric Acid Type A Receptor Alpha5 Subunit) is a Protein Coding gene. Diseases associated with GABRA5 include childhood absence epilepsy and angelman syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Circadian entrainment. GO annotations related to this gene include receptor activity and chloride channel activity. An important paralog of this gene is GABRA4.
UniProtKB/Swiss-Prot for GABRA5 Gene
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
GABAA receptors are members of the Cys-loop family of ligand-gated ion channels and, along with GABAB receptors, are responsible for mediating the inhibitory effects of GABA. They are pentameric proteins, consisting of five subunits belonging to different families.