Aliases for GABRA5 Gene
External Ids for GABRA5 Gene
Previous GeneCards Identifiers for GABRA5 Gene
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for GABRA5 Gene
GABRA5 (Gamma-Aminobutyric Acid Type A Receptor Alpha5 Subunit) is a Protein Coding gene. Diseases associated with GABRA5 include Angelman Syndrome and Prader-Willi Syndrome. Among its related pathways are Peptide ligand-binding receptors and Circadian entrainment. GO annotations related to this gene include receptor activity and chloride channel activity. An important paralog of this gene is GABRA1.
UniProtKB/Swiss-Prot for GABRA5 Gene
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
GABAA receptors are members of the Cys-loop family of ligand-gated ion channels and, along with GABAB receptors, are responsible for mediating the inhibitory effects of GABA. They are pentameric proteins, consisting of five subunits belonging to different families.