V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

GABRA4 Gene

protein-coding GIFtS: 63

GC04M046615

gamma-aminobutyric acid (GABA) A receptor, alpha 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Descriptions
GABA(A) receptor subunit alpha-4 ^³
gamma-aminobutyric acid (GABA) A receptor, alpha 4 ^²
gamma-aminobutyric acid A receptor, alpha 4 ^²

External Ids
HGNC: 4078¹
Entrez Gene: 2557²
UniProtKB: P48169³
Ensembl: ENSG00000109158⁷

Search outside databases for aliases for GABRA4 gene

Previous GC identifers: GC04M047001 GC04M047239 GC04M046778 GC04M046836 GC04M046761

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GABRA4:

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A

receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be

modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct

subunits of GABA-A receptors have been identified. [provided by RefSeq]

UniProtKB/Swiss-Prot: GBRA4_HUMAN, P48169

Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal

inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

Gene Wiki entry for GABRA4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GABRA4 gene

Entrez Gene cytogenetic band: 4p12 Ensembl cytogenetic band: 4p12 HGNC cytogenetic band: 4p12

GABRA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M046615: (about GC identifiers)

Start:	46,615,674 bp from pter
End:	46,690,337 bp from pter
Size:	74,664 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_006238.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: GBRA4_HUMAN, P48169 (See protein sequence)

Recommended Name: Gamma-aminobutyric acid receptor subunit alpha-4 precursor

Size: 554 amino acids; 61623 Da

Subunit: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma,

delta, and rho

Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane

protein. Cell membrane; Multi-pass membrane protein

Secondary accessions: Q8IYR7

REFSEQ proteins: NP_000800.2

ENSEMBL proteins:

ENSP00000264318

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GABA A Receptor alpha 4)
	Human Recombinant Proteins from Abnova (GABRA4)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	8719416
GO:0030054	cell junction	IEA	--
GO:0045202	synapse	IEA	--
GO:0045211	postsynaptic membrane	IEA	--

About this table

Antibodies for GABRA4:

	Invitrogen Antibodies for GABRA4
	Millipore Mono- and Polyclonal Antibodies for the study of GABRA4
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for GABRA4 (GABA-A-R alpha 4)
	Antibodies from Abcam (GABA A Receptor alpha 4), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for GABRA4

Assays for GABRA4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P48169

ProtoNet protein and cluster: P48169

4 Blocks protein families:

IPB001390 Gamma-aminobutyric-acid A receptor alpha subunit signature

IPB005434 Gamma-aminobutyric-acid A receptor alpha 4 subunit signature

IPB006028 Gamma-aminobutyric acid A (GABAA) receptor signature

IPB006201 Neurotransmitter-gated ion-channel

UniProtKB/Swiss-Prot: GBRA4_HUMAN, P48169

Similarity: Belongs to the ligand-gated ionic channel (TC 1.A.9) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GABRA4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GABRA4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000809

Applied Biosystems Silencer® siRNAs for GABRA4

Sigma-Aldrich siRNA and siRNA Panels for GABRA4

Sigma-Aldrich shRNA for GABRA4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GABRA4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000809
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000809
untagged cDNA clones in CMV expression vector (see all 2): NM_000809

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000809

UniProtKB/Swiss-Prot: GBRA4_HUMAN, P48169

Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal

inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

Induction: The alpha4 beta2 gamma 2L receptor is not repressed by diazepam

Genatlas biochemistry entry for GABRA4:

gamma-aminobutyric acid (GABA) A receptor,ionotropic,alpha 4,subunit,component of a pentameric

receptor mediating inhibitory neurotransmission

6 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Gabra4):

behavior/neurological	homeostasis/metabolism	nervous system	no phenotypic analysis	normal
touch/vibrissae

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004890	GABA-A receptor activity	IEA	--
GO:0005216	ion channel activity	IEA	--
GO:0005230	extracellular ligand-gated ion channel activity	IEA	--
GO:0005254	chloride channel activity	IEA	--
GO:0008503	benzodiazepine receptor activity	TAS	8719416

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for GABRA4 (Your Favorite Gene powered by Ingenuity)

GABA Receptor Signaling

GeneDecks GABRA4 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for GABRA4

5/19 Interacting proteins for GABRA4 (ENSP00000264318³) via UniProtKB, MINT, and/or STRING (see all 19 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GABRB3	ENSP00000372479³	STRING (score=.829)
GABRB2	ENSP00000274547³	STRING (score=.823)
GABRR1	ENSP00000358463³	STRING (score=.823)
GABRR2	ENSP00000229606³	STRING (score=.822)
GABRP	ENSP00000265294³	STRING (score=.82)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0006821	chloride transport	IEA	--
GO:0007214	gamma-aminobutyric acid signaling pathway	TAS	8719416

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for GABRA4

Sigma-Aldrich Small Molecules for GABRA4:

Antagonist Agonist Allosteric Modulator Inhibitor Ligand

Compounds for GABRA4 available from Tocris Bioscience

Compound	Action	CAS number
Muscimol	Potent GABAA agonist	[2763-96-4]
(+)-Bicuculline	Potent GABAA antagonist	[485-49-4]
Indiplon	Subtype-selective GABAA receptor positive allosteric modulator	[325715-02-4]
L-655,708	Selective for alpha5-containing GABAA receptors	[130477-52-0]
SR 95531 hydrobromide	Selective, competitive GABAA receptor antagonist	[104104-50-9]

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GABRA4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GABRA4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000809

Sigma-Aldrich siRNA and siRNA Panels for GABRA4

Sigma-Aldrich shRNA for GABRA4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000809

REFSEQ mRNAs for GABRA4 gene:

NM_000809.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000809

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000809
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000809
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000809

Additional cDNA sequence:

AF238869.1 AK090780.1 BC035055.1 BC036474.1 BC037926.2 BC042117.1 U30461.1

1 DOTS entry:

DT.75173889

24/33 AceView cDNA sequences (see all 33 ):

AK090780 BC037926 NM_000809 BI599812 BC042117 U30461 AL157669 BG204759

BG623491 BI545886 AL705643 CD013893 BX493490 BF310474 C15082 BG706756

BI545660 BC035055 BC036474 AV728959 BI598814 CD013892 BG201159 AF238869

highest scoring ESTs for GABRA4:

AK090780 BC035055 BG699585 BI545886 BI598814 BI599812 U30461 AF238869 AL157669 AL705643

Unigene Cluster for GABRA4:

Gamma-aminobutyric acid (GABA) A receptor, alpha 4

Hs.248112 [show with all ESTs]

Unigene Representative Sequence: NM_000809

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for GABRA4

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9
SP1:											-
SP2:							-				-
SP3:							-				-										-
SP4:

About this scheme

ECgene alternative splicing isoforms for GABRA4

1 Ensembl transcript including schematic representation:

ENST00000264318

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GABRA4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GABRA4

¹ / ² / ³

4 probe-sets matching GABRA4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
233437_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF238869	0.60	1.00	0.82	1
208463_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000809	0.60	1.00	0.82	1
233437_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208463_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGAAAAAGAA

SOURCE GeneReport for Unigene cluster: Hs.248112

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GABRA4 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GABRA4¹	--	gamma-aminobutyric acid (GABA) A receptor, alpha 4	91.27(n) 94.23(a)	482132 XM_539251.2 XP_539251.2
chimpanzee (Pan troglodytes)	GABRA4¹	--	gamma-aminobutyric acid (GABA) A receptor, alpha 4	99.58(n) 100(a)	471392 XM_526774.2 XP_526774.2
cow (Bos taurus)	GABRA4¹	--	gamma-aminobutyric acid (GABA) A receptor, alpha 4	92.06(n) 93.86(a)	282238 NM_174543.2 NP_776968.1
rat (Rattus norvegicus)	Gabra4¹	--	gamma-aminobutyric acid (GABA) A receptor, alpha 4	86.45(n) 89.84(a)	140675 NM_080587.1 NP_542154.1
mouse (Mus musculus)	Gabra4^{1, 5}	5⁵	gamma-aminobutyric acid (GABA) A receptor, subunit more⁵ gamma-aminobutyric acid (GABA-A) receptor, subunit more¹	87.3(n)¹ 90.93(a)¹	14397¹ NM_010251.2¹ NP_034381.1¹ AF090373⁵ AI852120⁵ (see all 14)

About this table Species with no ortholog for GABRA4

ENSEMBL Gene Tree for GABRA4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GABRA4 gene

GABRA6² GABRA3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/391 NCBI SNPs in GABRA4 are shown (see all 391 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 202)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs953380^1,2	A,C,F,H,O	46620570(-)	`AGGAAT/CGGAAT`	1	--	ut3¹		14	NS MN NA EU EA WA	956
	rs7660336^1,2	A,C,F,H	46624425(+)	`GGGAAC/GATATT`	1	--	ut3¹ trp³		8	EA NA EU WA	622
	rs9291298^1,2	A,C,F,H	46621594(+)	`AGAGAA/GTATTA`	1	--	ut3¹ ese³		7	NA EU EA WA	552
	rs9291297^1,2	A,C,F,H	46617865(+)	`GGATAA/CCATTT`	1	--	ut3¹		4	EU EA WA	388
	rs3762611^1,2	A,C,F,H	46692045(+)	`AAATAG/ACGGAA`	1	--	ng3¹		12	EA EU WA NA	2476
	rs1398174^1,2	A,C,F,H	46621902(-)	`CTTAAA/CAGTGA`	1	--	ut3¹ ese³		5	MN EU EA WA	602
	rs10033500^1,2	A,C,F,H	46617445(+)	`ACTCAC/TACCAA`	1	--	ut3¹		3	EU EA	282
	rs9291296^1,2	A,C,F,H	46617707(+)	`TTCAAA/GTACAT`	1	--	ut3¹		7	NA EU EA WA	544
	rs13151759^1,2	A,C,F,H	46690410(+)	`TTCTCG/TCTCAG`	1	--	ng3¹		4	EU EA WA	412
	rs1512139^1,2	A,C,F,O	46621534(-)	`CTTTGC/AACCAC`	1	--	ut3¹ ese³		8	MN NA EA	688

About this table

HapMap Linkage Disequilibrium images for GABRA4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 137141

2 Novoseek disease relationships for GABRA4 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
status epilepticus	57.49	4	16091474 (1), 16901909 (1)
epilepsy	29.15	5	16091474 (1), 16901909 (1)

About this table

Genetic Association Database: GABRA4
Human Genome Epidemiology Navigator: GABRA4 (7 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/26 PubMed articles for GABRA4 gene (see all 26 ):

Mapping of the alpha 4 subunit gene (GABRA4) to human chromosome 4 defines an alpha 2-alpha 4-beta 1-gamma 1 gene cluster: further evidence that modern GABAA receptor gene clusters are derived from an ancestral cluster. (PubMed id 7607683)^{2, 3, 4} McLean P.J.... Russek S.J. (1995)
Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. (PubMed id 16080114)^{1, 3, 6} Ma D.Q....Pericak-Vance M.A. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Cloning and characterization of the human GABAA receptor alpha 4 subunit: identification of a unique diazepam-insensitive binding site. (PubMed id 8719416)^{3, 4} Yang W.... Lan N.C. (1995)
Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia. (PubMed id 18334916)^{1, 3} Inada T....Arinami T. (2008)
Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and FagerstrAPm Test for Nicotine Dependence. (PubMed id 19207358)³ Agrawal A....Madden P.A. (2009)
Altered markers of tonic inhibition in the dorsolateral prefrontal cortex of subjects with schizophrenia. (PubMed id 19289452)³ Maldonado-AvilAcs J.G....Lewis D.A. (2009)
Strong genetic evidence for a selective influence of GABA(A) receptors on a component of the bipolar disorder phenotype. (PubMed id 19078961)³ Craddock N....O'Donovan M.C. (2008)
Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study. (PubMed id 18482426)³ Agrawal A....Madden P.A. (2008)
Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. (PubMed id 17135278)³ Saccone S.F....Bierut L.J. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2557	HGNC: 4078	AceView: GABRA4	Ensembl:ENSG00000109158	euGenes: HUgn2557
ECgene: GABRA4	H-InvDB: GABRA4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Protein Spotlight	http://www.expasy.org/spotlight/back_issues/sptlt056.shtml

Licensable Technologies for GABRA4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GABRA4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GABRA4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GABRA4		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GABRA4		Small molecules for GABRA4
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GABRA4)
	Search for Antibodies
	Chimera RNAi (GABRA4)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (GABA A Receptor alpha 4)
	Antibodies (GABA A Receptor alpha 4)

Search OriGene for GABRA4

Tocris compounds for GABRA4

	Drugs for GABRA4
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for GABRA4

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
GABRA4 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

GABRA4 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for GABRA4

Summaries
for GABRA4

Genomic Location
for GABRA4

Proteins
for GABRA4

Protein Domains/
Families
for GABRA4

Gene Function
for GABRA4

Pathways & Interactions
for GABRA4

Drugs & Compounds
for GABRA4

Transcripts
for GABRA4

Expression
for GABRA4

Orthologs
for GABRA4

Paralogs
for GABRA4

SNPs/Variants
for GABRA4

Disorders & Mutations
for GABRA4

Medical News
for GABRA4

Publications
for GABRA4

Search for GABRA4

Genome Databases showing GABRA4

Other Databases showing GABRA4

Specialized Databases showing GABRA4

Licensable Technologies
for GABRA4

Services
for GABRA4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GABRA4 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor GABRA4

Summariesfor GABRA4

Genomic Locationfor GABRA4

Proteinsfor GABRA4

Protein Domains/Familiesfor GABRA4

Gene Functionfor GABRA4

Pathways & Interactionsfor GABRA4

Drugs & Compoundsfor GABRA4

Transcriptsfor GABRA4

Expression for GABRA4

Orthologsfor GABRA4

Paralogsfor GABRA4

SNPs/Variantsfor GABRA4

Disorders & Mutationsfor GABRA4

Medical Newsfor GABRA4

Publicationsfor GABRA4

Search for GABRA4

Genome Databases showing GABRA4

Other Databases showing GABRA4

Specialized Databases showing GABRA4

Licensable Technologiesfor GABRA4

Servicesfor GABRA4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GABRA4

Summaries
for GABRA4

Genomic Location
for GABRA4

Proteins
for GABRA4

Protein Domains/
Families
for GABRA4

Gene Function
for GABRA4

Pathways & Interactions
for GABRA4

Drugs & Compounds
for GABRA4

Transcripts
for GABRA4

Expression
for GABRA4

Orthologs
for GABRA4

Paralogs
for GABRA4

SNPs/Variants
for GABRA4

Disorders & Mutations
for GABRA4

Medical News
for GABRA4

Publications
for GABRA4

Licensable Technologies
for GABRA4

Services
for GABRA4