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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GABRA3 Gene

protein-coding GIFtS: 64
GCID: GC0XM151334

gamma-aminobutyric acid (GABA) A receptor, alpha 3

Explore 20 diseases affiliated with
GABRA3 via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Gamma-Aminobutyric Acid (GABA) A Receptor, Alpha 3¹ ²
GABA(A) Receptor Subunit Alpha-3² ³
GABA(A) Receptor, Alpha 3²
Gamma-Aminobutyric Acid Receptor Subunit Alpha-3²
Gamma-Animobutyric Acid (GABA) A Receptor, Alpha 3²

External Ids:	HGNC: 4077¹	Entrez Gene: 2556²	Ensembl: ENSG00000011677⁷	OMIM: 305660⁵	UniProtKB: P34903³

Export aliases for GABRA3 gene to outside databases

Previous GC identifers: GC0XM145671 GC0XM147993 GC0XM149084 GC0XM149954 GC0XM151007 GC0XM151085 GC0XM140189

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GABRA3:

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are

ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as

benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been

identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GBRA3_HUMAN, P34903

Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding

to the GABA/benzodiazepine receptor and opening an integral chloride channel

summary for GABRA3:

GABAA receptors are members of the cys-loop family of ligand-gated ion channels, responsible for mediating

the inhibitory effects of GABA alongside GABAB and GABAC receptors. They are pentameric proteins, consisting

of 5 subunits belonging to different families (alpha1-6, beta1-3, gamma1-3, delta, pi, epsilon, rho, theta).

The most abundant GABAA receptor in the mammalian brain consist of two copies each of alpha1 and beta2 with

a single gamma2 subunits. GABAA receptors contain an integral chloride channel, and have modulatory sites

for benzodiazepines, barbiturates, neurosteroids and ethanol.

Gene Wiki entry for GABRA3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_167198.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GABRA3 gene promoter:
AML1a p53 Nkx2-5 NRSF form 2 Nkx5-1 C/EBPalpha PPAR-gamma1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GABRA3 promoter sequence

Search SABiosciences Chromatin IP Primers for GABRA3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GABRA3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28

GABRA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GABRA3 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM151334: view genomic region (about GC identifiers)

Start:	151,334,706 bp from pter	End:	151,620,337 bp from pter
Size:	285,632 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GBRA3_HUMAN, P34903 (See protein sequence)

Recommended Name: Gamma-aminobutyric acid receptor subunit alpha-3 precursor

Size: 492 amino acids; 55165 Da

Subunit: Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha,

beta, gamma, delta, and rho

Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane;

Multi-pass membrane protein

Secondary accessions: Q8TAF9

Explore the universe of human proteins at neXtProt for GABRA3: NX_P34903

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P34903

GABRA3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000799.1

ENSEMBL proteins:

ENSP00000359337 ENSP00000359334 ENSP00000413772 ENSP00000443527

Reactome Protein details: P34903
Human Recombinant Protein Products:

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Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	8391122
GO:0016021	integral to membrane	--	--
GO:0030054	cell junction	IEA	--
GO:0034707	chloride channel complex	IEA	--

GABRA3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GABRA3 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR005433 GABBAa3_rcpt

IPR001390 GABAAa_rcpt

IPR018000 Neurotransmitter_ion_chnl_CS

IPR006028 GABAA_rcpt

IPR006201 Neur_channel

Graphical View of Domain Structure for InterPro Entry P34903

ProtoNet protein and cluster: P34903

4 Blocks protein families:

IPB001390 Gamma-aminobutyric-acid A receptor alpha subunit signature

IPB005433 Gamma-aminobutyric-acid A receptor alpha 3 subunit signature

IPB006028 Gamma-aminobutyric acid A (GABAA) receptor signature

IPB006201 Neurotransmitter-gated ion-channel

UniProtKB/Swiss-Prot: GBRA3_HUMAN, P34903

Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5)

subfamily. GABRA3 sub-subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GBRA3_HUMAN, P34903

Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding

to the GABA/benzodiazepine receptor and opening an integral chloride channel

Genatlas biochemistry entry for GABRA3:

gamma-aminobutyric acid (GABA) A receptor,ionotropic,alpha 3,subunit,component of a pentameric receptor mediating

inhibitory neurotransmission

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABRA3

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004890	GABA-A receptor activity	IEA	--
GO:0005230	extracellular ligand-gated ion channel activity	IEA	--
GO:0005254	chloride channel activity	IEA	--
GO:0008503	benzodiazepine receptor activity	TAS	8391122

GABRA3 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for GABRA3:

Abundance of large cells with

Increased viability after born

Animal Models:
Mouse knock-out Gabra3^tm2Uru for GABRA3
4 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Gabra3):

behavior/neurological

homeostasis/metabolism

nervous system

no phenotypic analysis

GABRA3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Transmission across Chemical Synapses

	Transmission across Chemical Synapses	1.00			Neuronal System	0.67
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	0.72

GABA A receptor activation

	GABA A receptor activation	1.00			GABA signaling in brain	0.26
	Ligand-gated ion channel transport	0.48

Ion channel transport

Ion channel transport

1.00

Akt Signaling

Akt Signaling

1.00

Activation of GABAB receptors

GABA receptor activation

0.72

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for GABRA3

GABA signaling in brain

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GABRA3

	Sperm Motility
	Akt Signaling

1 Tocris Bioscience Pathway for GABRA3

Akt Pathway

5/8 Reactome Pathways for GABRA3 (see all 8)

	GABA A receptor activation
	Ligand-gated ion channel transport
	Transmission across Chemical Synapses
	Ion channel transport
	Neuronal System

1 Kegg Pathway (Kegg details for GABRA3):

Neuroactive ligand-receptor interaction

GABRA3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GABRA3

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/14 Interacting proteins for GABRA3 (P34903^{2, 3} ENSP00000359334⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PIK3R1	P27986²^,³, ENSP00000274335⁴	MINT-8112015 I2D: score=3 STRING: ENSP00000274335
UBQLN1	Q9UMX0³, ENSP00000365576⁴	I2D: score=1 STRING: ENSP00000365576
GABRA1	ENSP00000023897⁴	STRING: ENSP00000023897
GABRA2	ENSP00000348897⁴	STRING: ENSP00000348897
GABRA4	ENSP00000264318⁴	STRING: ENSP00000264318

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	TAS	8391122
GO:0007214	gamma-aminobutyric acid signaling pathway	IEA	--
GO:0007268	synaptic transmission	TAS	--
GO:0034220	ion transmembrane transport	TAS	--
GO:0055085	transmembrane transport	TAS	--

GABRA3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for GABRA3 available from Tocris Bioscience About this table

Compound	Action	CAS #
Muscimol	Potent GABAA agonist	[2763-96-4]
(+)-Bicuculline	Potent GABAA antagonist	[485-49-4]
L-655,708	Selective for alpha5-containing GABAA receptors	[130477-52-0]
AA 29504	Positive allosteric modulator of GABAA receptors	[945828-50-2]
SR 95531 hydrobromide	Selective, competitive GABAA receptor antagonist	[104104-50-9]

2 HMDB Compounds for GABRA3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Chlorine	Cl2 (see all 13)	16887-00-6	--
Gamma-Aminobutyric acid	3-Carboxypropylamine (see all 27)	56-12-2	--

10/46 DrugBank Compounds for GABRA3 (see all 46) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Flumazenil	Flumazenilo [Spanish] (see all 2)	78755-81-4	target	--	17306436 19907641 18788841 17368613 19411525 18175099
Diazepam	--	439-14-5	target	potentiator	18384456 11752090 15009644
Flunitrazepam	--	1622-62-4	target	potentiator	17139284 17016423 20638393
Lorazepam	(+/-)-Lorazepam (see all 3)	846-49-1	target	potentiator	20138190 18384456 11752090
Methylphenobarbital	Mephobarbital (see all 13)	115-38-8	target	potentiator	10209232 11264449 21194017
Zopiclone	(+-)-zopiclone (see all 4)	43200-80-2	target	potentiator	20303942 19942638 18973287
Adinazolam	--	37115-32-5	target	potentiator	6320036 6148400
Amobarbital	--	57-43-2	target	potentiator	10209232 11264449
Aprobarbital	--	77-02-1	target	potentiator	10209232 11264449
Barbital	--	57-44-3	target	potentiator	10209232 11264449

Search CenterWatch for drugs/clinical trials and news about GABRA3 / GBRA3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GABRA3 gene:

NM_000808.3

Unigene Cluster for GABRA3:

Gamma-aminobutyric acid (GABA) A receptor, alpha 3

Hs.123024 [show with all ESTs]

Unigene Representative Sequence: NM_000808

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000370314(uc010ntk.1) ENST00000370311 ENST00000497894 ENST00000417858

ENST00000535043

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Additional cDNA sequence:

AK312404.1 BC028629.1 S62908.1

3 DOTS entries:

DT.40125283 DT.91933487 DT.91755251

2 AceView cDNA sequences:

BX951994 BI546888

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GABRA3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

GABRA3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Thoracic Perivascular Adipose

Adipose

Visceral White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See GABRA3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GABRA3

SOURCE GeneReport for Unigene cluster: Hs.123024

SABiosciences Custom PCR Arrays for GABRA3

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for GABRA3 gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	GABRA3¹	gamma-aminobutyric acid (GABA) A receptor, alpha 3	77.83(n) 84.55(a)		422289 XM_420268.2 XP_420268.2
lizard (Anolis carolinensis)	Reptilia	GABRA3⁶	--	84(a)	1 ↔ 1	GL343376.1(966235-973505)
zebrafish (Danio rerio)	Actinopterygii	gabra3⁶ CABZ01113152.1⁶ (see all 3)	--	80(a) 49(a) (see all 3)	1 ↔ 1 possible ortholog (see all 3)	21(42810115-43145999) Zv9_NA834(19752-41261)
fruit fly (Drosophila melanogaster)	Insecta	Grd^{1 , 3}	glycine-gated ion channel³ Glycine receptor¹	46(a) (best of 2)³ 51.81(n)¹ 44.58(a)¹		75A4³ 39984¹ NM_079407.2¹ NP_524131.1¹
worm (Caenorhabditis elegans)	Secernentea	T15B7.16³ lgc-37¹	ligand-gated ionic channel protein³ Protein LGC-37¹	30(a) (best of 2)³ 48.32(n)¹ 37.88(a)¹		V(6843108-6845571)³ 176694¹ NM_067261.3¹ NP_499662.2¹

ENSEMBL Gene Tree for GABRA3 (if available)
TreeFam Gene Tree for GABRA3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GABRA3 gene

GABRG2² GABRE² GABRA2² GABRA6² GABRA4² GABRG1² GABRG3² GABRA5²

GABRA1²

18/24 SIMAP similar genes for GABRA3 using alignment to 2 protein entries: GBRA3_HUMAN (see all proteins) (see all similar genes):

GABRA5 GABRA2 GABRA6 GABRA1 GABRA4 GABRG2

GABRG3 GABRE GABRG1 GABRB1 GABRB3 GABRP

GLRA4 GLRA3 DKFZp781L0846 GLRA2 GLRA1 GABRR1

GABRA3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141143001^1,2		--	151335168(+)	`TGGGCC/TGAGAC`	1	--	ds500¹		0	--	--	--	--
rs143647370^1,2		--	151335265(+)	`GGCCCA/GCTGAG`	1	--	ds500¹		0	--	--	--	--
rs112122339^1,2	C,	--	151335432(+)	`ATTGCA/GTATTT`	1	--	ds500¹		0	--	--	--	--
rs79083979^1,2	C,	--	151335459(+)	`CTCAC-/ATTAAG ATTAA`	1	--	ds500¹		0	--	--	--	--
rs113375398^1,2		--	151335493(+)	`TAATAA/TATTAT`	1	--	ds500¹		0	--	--	--	--
rs141889429^1,2		--	151335498(+)	`TATTAG/TAAAAT`	1	--	ds500¹		0	--	--	--	--
rs7881645^1,2	C,F,H,	--	151335637(+)	`AAGTGC/TCTGGG`	1	--	ut3¹ ese³		9		NS EA NA	1184
rs183883309^1,2	C,	--	151335682(+)	`AATTTG/TACTTT`	1	--	ut3¹		0	--	--	--	--
rs139149792^1,2	C,	--	151335703(+)	`TAGCCC/TTCTCT`	1	--	ut3¹		0	--	--	--	--
rs188776599^1,2		--	151335796(+)	`AGGTGA/TCTTTT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GABRA3 (151334706 - 151584706 bp, first 250kb of GABRA3)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for GABRA3
1 CNV: 68058

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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GABRA3 for disorders           About GeneDecksing

OMIM gene information: 305660    OMIM disorders: --

20 diseases for GABRA3:    About MalaCards

manic-depressive illness autism spectrum disorder mucopolysaccharidosis ii color blindness

centronuclear myopathy anorexia nervosa rett syndrome mucopolysaccharidosis

migraine angelman syndrome bipolar disorder multiple sclerosis

myopathy paralysis genetic disease hepatocellular carcinoma

blindness lung cancer carcinoma neuronitis

1 disease from the University of Copenhagen DISEASES database for GABRA3:

Color blindness

Genetic Association Database (GAD): GABRA3
Human Genome Epidemiology (HuGE) Navigator: GABRA3 (18 documents)

Export disorders for GABRA3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GABRA3 gene, integrated from 9 sources (see all 74):
(articles sorted by number of sources associating them with GABRA3)

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Lack of association between polymorphic variations in the alpha 3 subunit GABA receptor gene (GABRA3) and suicide attempts. (PubMed id 14751442)^{1, 4, 9} Baca-Garcia E....de Leon J. (2004)
The gamma amino butyric acid (GABA) receptor alpha-3 subunit gene polymorphism in unipolar depressive disorder: a genetic association study. (PubMed id 15048654)^{1, 4} Henkel V....Bondy B. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Excess of allele1 for alpha3 subunit GABA receptor gene (GABRA3) in bipolar patients: a multicentric association study. (PubMed id 11840313)^{1, 4} Massat I....Mendlewicz J. (2002)
Lack of association between GABRA3 and unipolar affective disorder: a multicentre study. (PubMed id 11602034)^{1, 4} Massat I....Mendlewicz J. (2001)
GABA-A receptor beta3 and alpha5 subunit gene cluster on chromosome 15q11-q13 and bipolar disorder: a genetic association study. (PubMed id 11378843)^{1, 4} Papadimitriou G.N....Stefanis C.N. (2001)
Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq. (PubMed id 10602120)^{1, 2} Amir R.... Zoghbi H.Y. (2000)
Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma- aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors. (PubMed id 8391122)^{1, 2} Hadingham K.L.... Whiting P.J. (1993)
Gamma-aminobutyric acid promotes human hepatocellular carcinoma growth through overexpressed gamma-aminobutyric acid A receptor alpha 3 subunit. (PubMed id 19084931)^{1, 9} Liu Y....Li G.C. (2008)
Association of genetic variants in GABRA3 gene and thyrotoxic hypokalaemic periodic paralysis in Thai population. (PubMed id 17970773)^{1, 9} Jongjaroenprasert W....Ongphiphadhanakul B. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2556	HGNC: 4077	AceView: GABRA3.1	Ensembl:ENSG00000011677	euGenes: HUgn2556
ECgene: GABRA3	Kegg: 2556	H-InvDB: GABRA3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GABRA3	Pharmacogenomics, SNPs, Pathways
Protein Spotlight	http://web.expasy.org/spotlight/back_issues/sptlt056.shtml

Intellectual Property for GABRA3 gene
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Patent Information for GABRA3 gene:
Search GeneIP for patents involving GABRA3

GeneCards and IP:
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gamma-aminobutyric acid (GABA) A receptor, alpha 3

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gamma-aminobutyric acid (GABA) A receptor, alpha 3

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