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Aliases for GABRA3 Gene

Aliases for GABRA3 Gene

  • Gamma-Aminobutyric Acid (GABA) A Receptor, Alpha 3 2 3
  • GABA(A) Receptor Subunit Alpha-3 4
  • GABA(A) Receptor 2
  • Alpha 3 2

External Ids for GABRA3 Gene

Previous GeneCards Identifiers for GABRA3 Gene

  • GC0XM145671
  • GC0XM147993
  • GC0XM149084
  • GC0XM149954
  • GC0XM151007
  • GC0XM151085
  • GC0XM151334
  • GC0XM140189

Summaries for GABRA3 Gene

Entrez Gene Summary for GABRA3 Gene

  • GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for GABRA3 Gene

GABRA3 (Gamma-Aminobutyric Acid (GABA) A Receptor, Alpha 3) is a Protein Coding gene. Diseases associated with GABRA3 include thyrotoxic periodic paralysis and color blindness. Among its related pathways are Akt Signaling and Apoptosis Pathway. GO annotations related to this gene include chloride channel activity and GABA-A receptor activity. An important paralog of this gene is GABRA4.

UniProtKB/Swiss-Prot for GABRA3 Gene

  • GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

Tocris Summary for GABRA3 Gene

  • GABAA receptors are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of GABA alongside GABAB and GABAC receptors. They are pentameric proteins, consisting of 5 subunits belonging to different families (alpha1-6, beta1-3, gamma1-3, delta, pi, epsilon, rho, theta). The most abundant GABAA receptor in the mammalian brain consist of two copies each of alpha1 and beta2 with a single gamma2 subunits. GABAA receptors contain an integral chloride channel, and have modulatory sites for benzodiazepines, barbiturates, neurosteroids and ethanol.

Gene Wiki entry for GABRA3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GABRA3 Gene

Genomics for GABRA3 Gene

Regulatory Elements for GABRA3 Gene

Genomic Location for GABRA3 Gene

Start:
152,166,234 bp from pter
End:
152,451,359 bp from pter
Size:
285,126 bases
Orientation:
Minus strand

Genomic View for GABRA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GABRA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GABRA3 Gene

Proteins for GABRA3 Gene

  • Protein details for GABRA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34903-GBRA3_HUMAN
    Recommended name:
    Gamma-aminobutyric acid receptor subunit alpha-3
    Protein Accession:
    P34903
    Secondary Accessions:
    • Q8TAF9

    Protein attributes for GABRA3 Gene

    Size:
    492 amino acids
    Molecular mass:
    55165 Da
    Quaternary structure:
    • Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

neXtProt entry for GABRA3 Gene

Proteomics data for GABRA3 Gene at MOPED

Post-translational modifications for GABRA3 Gene

  • Glycosylation at Asn63, Asn163, Asn176, and Asn228
  • Modification sites at PhosphoSitePlus

Other Protein References for GABRA3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GABRA3 Gene

Domains for GABRA3 Gene

Gene Families for GABRA3 Gene

HGNC:
  • GABR :GABA receptors
  • GABRA :Ligand-gated ion channels / GABA(A) receptors
IUPHAR :

Suggested Antigen Peptide Sequences for GABRA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P34903

UniProtKB/Swiss-Prot:

GBRA3_HUMAN :
  • P34903
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA3 sub-subfamily.
genes like me logo Genes that share domains with GABRA3: view

Function for GABRA3 Gene

Molecular function for GABRA3 Gene

GENATLAS Biochemistry: gamma-aminobutyric acid (GABA) A receptor,ionotropic,alpha 3,subunit,component of a pentameric receptor mediating inhibitory neurotransmission
UniProtKB/Swiss-Prot Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

Gene Ontology (GO) - Molecular Function for GABRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004890 GABA-A receptor activity IEA --
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0005254 chloride channel activity IEA --
GO:0008503 benzodiazepine receptor activity TAS 8391122
genes like me logo Genes that share ontologies with GABRA3: view
genes like me logo Genes that share phenotypes with GABRA3: view

Animal Models for GABRA3 Gene

MGI Knock Outs for GABRA3:

Animal Model Products

CRISPR Products

miRNA for GABRA3 Gene

miRTarBase miRNAs that target GABRA3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GABRA3 Gene

Localization for GABRA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GABRA3 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GABRA3 Gene COMPARTMENTS Subcellular localization image for GABRA3 gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GABRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8391122
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with GABRA3: view

Pathways for GABRA3 Gene

genes like me logo Genes that share pathways with GABRA3: view

Interacting Proteins for GABRA3 Gene

Selected Interacting proteins: P34903-GBRA3_HUMAN for GABRA3 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for GABRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8391122
GO:0006811 ion transport --
GO:0007214 gamma-aminobutyric acid signaling pathway IEA --
GO:0007268 synaptic transmission TAS --
GO:0034220 ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with GABRA3: view

Compounds for GABRA3 Gene

(5) Tocris Compounds for GABRA3 Gene

Compound Action Cas Number
L-655,708 Selective for alpha5-containing GABAA receptors [130477-52-0]
(-)-Bicuculline methiodide Water-soluble GABAA antagonist [40709-69-1]
(-)-Bicuculline methochloride Water-soluble GABAA antagonist [53552-05-9]
Muscimol Potent GABAA agonist [2763-96-4]
SR 95531 hydrobromide Selective, competitive GABAA receptor antagonist [104104-50-9]

(2) HMDB Compounds for GABRA3 Gene

Compound Synonyms Cas Number PubMed IDs
Chlorine
  • Cl2
16887-00-6
Gamma-Aminobutyric acid
  • 3-Carboxypropylamine
56-12-2

(45) Drugbank Compounds for GABRA3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adinazolam
37115-32-5 target potentiator
Alprazolam
28981-97-7 target potentiator
Amobarbital
57-43-2 target potentiator
Aprobarbital
77-02-1 target potentiator
Barbital
57-44-3 target potentiator

(34) IUPHAR Ligand for GABRA3 Gene

Ligand Type Action Affinity Pubmed IDs
piperidine-4-sulphonic acid Agonist Full agonist
5alpha-pregnan-3alpha-ol-20-one Allosteric regulator Potentiation
[3H]flunitrazepam None None
[35S]TBPS None None
TPA023 Allosteric regulator Antagonist
[3H]muscimol None None
isoguvacine Agonist Full agonist
isonipecotic acid Agonist Full agonist
[11C]flumazenil None None
alpha5IA Allosteric regulator Inverse agonist
DMCM Allosteric regulator Inverse agonist
flunitrazepam Allosteric regulator Full agonist
[18F]fluoroethylflumazenil None None
bretazenil Allosteric regulator Full agonist
Ro4938581 Allosteric regulator Inverse agonist
THIP Agonist Agonist
alpha3IA Allosteric regulator Inverse agonist
Ro194603 Allosteric regulator Inverse agonist
tetrahydrodeoxycorticosterone Allosteric regulator Potentiation
gabazine Antagonist Antagonist
TBPS Channel blocker None
L838417 Allosteric regulator Partial agonist
muscimol Agonist Full agonist
ocinaplon Allosteric regulator Partial agonist
[3H]CGS8216 None None
picrotoxin Channel blocker None
diazepam Allosteric regulator Full agonist
MRK016 Allosteric regulator Inverse agonist
flumazenil Allosteric regulator Partial agonist
ZK93426 Allosteric regulator Antagonist
[3H]gabazine None None
TP003 Allosteric regulator Antagonist
Ro154513 Allosteric regulator Full agonist
bicuculline Antagonist Antagonist
genes like me logo Genes that share compounds with GABRA3: view

Transcripts for GABRA3 Gene

mRNA/cDNA for GABRA3 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GABRA3 Gene

Gamma-aminobutyric acid (GABA) A receptor, alpha 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GABRA3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GABRA3 Gene

No ASD Table

Relevant External Links for GABRA3 Gene

GeneLoc Exon Structure for
GABRA3
ECgene alternative splicing isoforms for
GABRA3

Expression for GABRA3 Gene

mRNA expression in normal human tissues for GABRA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GABRA3 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (9.9), Brain - Frontal Cortex (BA9) (8.1), Brain - Hypothalamus (7.2), Brain - Cortex (6.8), and Brain - Hippocampus (5.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for GABRA3 Gene

SOURCE GeneReport for Unigene cluster for GABRA3 Gene Hs.123024

genes like me logo Genes that share expressions with GABRA3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GABRA3 Gene

Orthologs for GABRA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GABRA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GABRA3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GABRA3 35
  • 93.63 (n)
  • 96.95 (a)
GABRA3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GABRA3 35
  • 93.63 (n)
  • 97.56 (a)
GABRA3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gabra3 35
  • 91.11 (n)
  • 96.33 (a)
Gabra3 16
Gabra3 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GABRA3 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GABRA3 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gabra3 35
  • 90.51 (n)
  • 96.54 (a)
chicken
(Gallus gallus)
Aves GABRA3 35
  • 79.73 (n)
  • 87.39 (a)
GABRA3 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GABRA3 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gabra3 35
  • 73.39 (n)
  • 82.02 (a)
zebrafish
(Danio rerio)
Actinopterygii gabra3 36
  • 82 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011349 35
  • 39.92 (n)
  • 29.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta Grd 35
  • 53.64 (n)
  • 47.27 (a)
CG8916 37
  • 45 (a)
Grd 37
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea Y71D11A.5 37
  • 28 (a)
T15B7.16 37
  • 30 (a)
Species with no ortholog for GABRA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GABRA3 Gene

ENSEMBL:
Gene Tree for GABRA3 (if available)
TreeFam:
Gene Tree for GABRA3 (if available)

Paralogs for GABRA3 Gene

Paralogs for GABRA3 Gene

Selected SIMAP similar genes for GABRA3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GABRA3: view

Variants for GABRA3 Gene

Sequence variations from dbSNP and Humsavar for GABRA3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs370977 -- 152,361,686(+) tgtgt(A/G)gccat intron-variant
rs389292 -- 152,372,982(+) CAGTC(C/T)TTCTT intron-variant
rs411018 -- 152,371,215(-) gagtg(A/G)gagag intron-variant
rs440332 -- 152,369,929(+) GTTAA(A/G)AAGGA intron-variant
rs584473 -- 152,346,772(+) atgca(A/T)atcac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GABRA3 Gene

Variant ID Type Subtype PubMed ID
nsv516934 CNV Gain+Loss 19592680
nsv513629 CNV Insertion 21212237
esv1157238 CNV Insertion 17803354
esv1092318 CNV Insertion 17803354
esv1010518 CNV Loss 20482838
esv2740614 CNV Deletion 23290073
esv2740615 CNV Deletion 23290073
esv995871 CNV Loss 20482838
esv1338349 CNV Insertion 17803354
nsv508814 CNV Insertion 20534489
esv25153 CNV Loss 19812545
nsv7157 CNV Insertion 18451855

Relevant External Links for GABRA3 Gene

HapMap Linkage Disequilibrium report
GABRA3
Human Gene Mutation Database (HGMD)
GABRA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GABRA3 Gene

Disorders for GABRA3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for GABRA3 Gene including...

Search for GABRA3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for GABRA3 Gene

Relevant External Links for GABRA3

Genetic Association Database (GAD)
GABRA3
Human Genome Epidemiology (HuGE) Navigator
GABRA3
genes like me logo Genes that share disorders with GABRA3: view

No data available for UniProtKB/Swiss-Prot for GABRA3 Gene

Publications for GABRA3 Gene

  1. Lack of association between polymorphic variations in the alpha 3 subunit GABA receptor gene (GABRA3) and suicide attempts. (PMID: 14751442) Baca-Garcia E. … de Leon J. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2004) 3 23 48
  2. Association of genetic variants in GABRA3 gene and thyrotoxic hypokalaemic periodic paralysis in Thai population. (PMID: 17970773) Jongjaroenprasert W. … Ongphiphadhanakul B. (Clin. Endocrinol. (Oxf) 2008) 3 23 48
  3. Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia. (PMID: 18334916) Inada T. … Arinami T. (Pharmacogenet. Genomics 2008) 3 23 48
  4. Association study between GABA receptor genes and anxiety spectrum disorders. (PMID: 19842164) Pham X. … Hettema J.M. (Depress Anxiety 2009) 3 23 48
  5. Gammaaminobutyric acid A receptor alpha 3 subunit is overexpressed in lung cancer. (PMID: 19048400) Liu Y. … Li G. (Pathol. Oncol. Res. 2009) 3 23

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