Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GABRA1 Gene

protein-coding   GIFtS: 68
GCID: GC05P161206

Gamma-Aminobutyric Acid (GABA) A Receptor, Alpha 1

  See GABRA1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Gamma-Aminobutyric Acid (GABA) A Receptor, Alpha 11 2     GABA(A) Receptor1
GABA(A) Receptor Subunit Alpha-12 3     EJM2
ECA42 5     GABA(A) Receptor, Alpha 12
EJM52 5     Gamma-Aminobutyric Acid Receptor Subunit Alpha-12
Alpha 11     

External Ids:    HGNC: 40751   Entrez Gene: 25542   Ensembl: ENSG000000223557   OMIM: 1371605   UniProtKB: P148673   

Export aliases for GABRA1 gene to outside databases

Previous GC identifers: GC05P161391 GC05P161782 GC05P161209 GC05P161255 GC05P156366


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GABRA1 Gene:
This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the
mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance
of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A
receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho.
Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple
transcript variants encoding the same protein have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for GABRA1 Gene:
GABRA1 (gamma-aminobutyric acid (GABA) A receptor, alpha 1) is a protein-coding gene. Diseases associated with GABRA1 include epilepsy, childhood absence, susceptibility to, 4, and epileptic encephalopathy, early infantile, 19. GO annotations related to this gene include drug binding and extracellular ligand-gated ion channel activity. An important paralog of this gene is GABRG2.

UniProtKB/Swiss-Prot: GBRA1_HUMAN, P14867
Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by
binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

summary for GABRA1 Gene:
GABAA receptors are members of the cys-loop family of ligand-gated ion channels, responsible for mediating
the inhibitory effects of GABA alongside GABAB and GABAC receptors. They are pentameric proteins, consisting
of 5 subunits belonging to different families (alpha1-6, beta1-3, gamma1-3, delta, pi, epsilon, rho, theta).
The most abundant GABAA receptor in the mammalian brain consist of two copies each of alpha1 and beta2 with
a single gamma2 subunits. GABAA receptors contain an integral chloride channel, and have modulatory sites
for benzodiazepines, barbiturates, neurosteroids and ethanol.

Gene Wiki entry for GABRA1 (Gamma-aminobutyric acid A receptor, alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the GABRA1 gene promoter:
         TBP   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): GABRA1 promoter sequence
   Search Chromatin IP Primers for GABRA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GABRA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q34   Ensembl cytogenetic band:  5q34   HGNC cytogenetic band: 5q34

GABRA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GABRA1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P161206:  view genomic region     (about GC identifiers)

Start:
161,274,197 bp from pter      End:
161,326,975 bp from pter
Size:
52,779 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GBRA1_HUMAN, P14867 (See protein sequence)
Recommended Name: Gamma-aminobutyric acid receptor subunit alpha-1 precursor  
Size: 456 amino acids; 51802 Da
Subunit: Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains:
alpha, beta, gamma, delta, and rho. Interacts with TRAK1 (By similarity)
Secondary accessions: D3DQK6 Q8N629

Explore the universe of human proteins at neXtProt for GABRA1: NX_P14867

Explore proteomics data for GABRA1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn38, Asn138
  • Modification sites at PhosphoSitePlus

  • See GABRA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_000797.2  NP_001121115.1  NP_001121116.1  NP_001121117.1  NP_001121120.1  

    ENSEMBL proteins: 
     ENSP00000023897   ENSP00000393097   ENSP00000377517   ENSP00000415441   ENSP00000430895  
     ENSP00000430507   ENSP00000430435   ENSP00000408041   ENSP00000414232  
    Reactome Protein details: P14867

    GABRA1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GABRA1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GABRA1
    GenScript Custom Purified and Recombinant Proteins Services for GABRA1
    Novus Biologicals GABRA1 Protein
    Novus Biologicals GABRA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GABRA1 

     
    antibodies-online proteins for GABRA1 (2 products) 

     
    antibodies-online peptides for GABRA1

    GABRA1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GABRA1
    R&D Systems Antibodies for GABRA1 (GABA-A R alpha 1)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GABRA1
    Novus Biologicals GABRA1 Antibodies
    Abcam antibodies for GABRA1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for GABRA1
    LSBio Antibodies in human, mouse, rat for GABRA1
    antibodies-online antibodies for GABRA1 (79 products) 

    GABRA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GABRA1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GABRA1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for GABRA1 
    antibodies-online kits for GABRA1 (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    GABRA: Ligand-gated ion channels / GABA(A) receptors
    GABR: GABA receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: alpha1
    GABAA receptors

    Selected InterPro protein domains (see all 7):
     IPR001390 GABAAa_rcpt
     IPR018000 Neurotransmitter_ion_chnl_CS
     IPR006028 GABAA_rcpt
     IPR006201 Neur_channel
     IPR005431 GABBAa1_rcpt

    Graphical View of Domain Structure for InterPro Entry P14867

    ProtoNet protein and cluster: P14867

    4 Blocks protein domains:
    IPB001390 Gamma-aminobutyric-acid A receptor alpha subunit signature
    IPB005431 Gamma-aminobutyric-acid A receptor alpha 1 subunit signature
    IPB006028 Gamma-aminobutyric acid A (GABAA) receptor signature
    IPB006201 Neurotransmitter-gated ion-channel


    UniProtKB/Swiss-Prot: GBRA1_HUMAN, P14867
    Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC
    1.A.9.5) subfamily. GABRA1 sub-subfamily


    Find genes that share domains with GABRA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBRA1_HUMAN, P14867
    Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by
    binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

         Genatlas biochemistry entry for GABRA1:
    gamma-aminobutyric acid (GABA) A receptor,ionotropic,alpha 1,subunit,component of a pentameric receptor mediating
    inhibitory neurotransmission

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004890GABA-A receptor activity IEA--
    GO:0005230extracellular ligand-gated ion channel activity IEA--
    GO:0005254chloride channel activity IEA--
    GO:0005515protein binding ----
    GO:0008144drug binding ISS--
         
    Find genes that share ontologies with GABRA1           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 12 alleles(MGI details for Gabra1):
     behavior/neurological  growth/size/body  hearing/vestibular/ear  homeostasis/metabolism  mortality/aging 
     nervous system  no phenotypic analysis  normal  reproductive system 

    Find genes that share phenotypes with GABRA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GABRA1: Gabra1tm1.1Twr Gabra1tm1Twr Gabra1tm2.1Geh Gabra1tm1.1Geh

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GABRA1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GABRA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GABRA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GABRA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target GABRA1:
    hsa-mir-335-5p (MIRT019183)

    Block miRNA regulation of human, mouse, rat GABRA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GABRA1 (see all 48):
    hsa-miR-3607-3p hsa-miR-4272 hsa-miR-938 hsa-miR-3658 hsa-miR-208b hsa-miR-208a hsa-miR-155 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidGABRA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GABRA1
    Predesigned siRNA for gene silencing in human, mouse, rat GABRA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GABRA1

    Clone
    Products:
         
    OriGene clones in human, mouse for GABRA1 (see all 38)
    OriGene ORF clones in mouse, rat for GABRA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): GABRA1 (NM_000806)
    Sino Biological Human cDNA Clone for GABRA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GABRA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GABRA1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GABRA1
    Browse ESI BIO Cell Lines and PureStem Progenitors for GABRA1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABRA1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11703) for GABRA1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GBRA1_HUMAN, P14867: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell
    membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane ISS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0030054cell junction IEA--

    Find genes that share ontologies with GABRA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GABRA1 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1GABA signaling in brain
    Synaptic Neurotransmission: GABAergic Inhibition0.32
    GABA signaling in brain0.32
    2Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    3Circadian entrainment
    GABAergic synapse0.53
    Retrograde endocannabinoid signaling0.51
    Morphine addiction0.53
    4Ligand-gated ion channel transport
    GABA A receptor activation0.00
    Ligand-gated ion channel transport
    5GABA receptor activation
    GABA receptor activation0.73


    Find genes that share SuperPaths with GABRA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for GABRA1
        Synaptic Neurotransmission: GABAergic Inhibition

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GABRA1
        Sperm Motility
    Akt Signaling

    1 Tocris Bioscience Pathway for GABRA1
        Akt Pathway

    1 BioSystems Pathway for GABRA1
        SIDS Susceptibility Pathways


    2 Reactome Pathways for GABRA1
        GABA A receptor activation
    Ligand-gated ion channel transport

    1 PharmGKB Pathway for GABRA1
        Benzodiazepine Pathway, Pharmacodynamics

    5 Kegg Pathways  (Kegg details for GABRA1):
        Neuroactive ligand-receptor interaction
    Retrograde endocannabinoid signaling
    GABAergic synapse
    Morphine addiction
    Nicotine addiction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GABRA1: 
              Neurotransmitter Receptors in human mouse rat
              GABA & Glutamate in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GABRA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for GABRA1 (P148673 ENSP000000238974) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP3CAQ082093, ENSP000003783234I2D: score=2 STRING: ENSP00000378323
    PRKCDQ056553, ENSP000003316024I2D: score=2 STRING: ENSP00000331602
    PRKCGP051293, ENSP000002634314I2D: score=2 STRING: ENSP00000263431
    DRD4P219173, ENSP000001761834I2D: score=1 STRING: ENSP00000176183
    PIK3R1P279863, ENSP000002743354I2D: score=1 STRING: ENSP00000274335
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS2465923
    GO:0006811ion transport ----
    GO:0007214gamma-aminobutyric acid signaling pathway IEA--
    GO:0007268synaptic transmission TAS--
    GO:0034220ion transmembrane transport TAS--

    Find genes that share ontologies with GABRA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GABRA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (+)-BicucullinePotent GABAA antagonist[485-49-4]
    MuscimolPotent GABAA agonist[2763-96-4]
    (-)-Bicuculline methiodideWater-soluble GABAA antagonist[40709-69-1]
    (-)-Bicuculline methochlorideWater-soluble GABAA antagonist[53552-05-9]
    SR 95531 hydrobromide Selective, competitive GABAA receptor antagonist [104104-50-9]

    5 HMDB Compounds for GABRA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    Gamma-Aminobutyric acid3-Carboxypropylamine (see all 27)56-12-2--
    TopiramateEpitomax (see all 5)97240-79-4--
    ZolpidemAmbien (see all 7)82626-48-0--

    Selected DrugBank Compounds for GABRA1 (see all 67)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    PentobarbitalPentabarbital (see all 7)76-74-4targetpotentiator16866778 14579514 15240758 10209232 11264449 17139284 11752352 17016423 10487207 11744750 11605100
    Secobarbital(+/-)-Secobarbital (see all 6)76-73-3targetpotentiator2850060 3006661 14579514 10209232 11264449 17139284 11752352 17016423 10487207 2906155
    MethylphenobarbitalMephobarbital (see all 13)115-38-8targetpotentiator20692323 14579514 10209232 11264449 17139284 21194017 11752352 17016423 10487207
    ButalbitalAllylbarbital (see all 2)77-26-9targetpotentiator11279945 14579514 10209232 11264449 17139284 11752352 17016423 10487207
    Hexobarbital5-(1-cyclohexen-1-yl)-1,5-dimethylbarbituric acid (see all 4)56-29-1targetpotentiator14579514 10209232 11264449 17139284 11752352 17016423 10487207 10360871
    Thiamylal-- 77-27-0targetagonist11900777 14579514 10209232 18619475 11264449 17139284 10487207 17016423
    ButabarbitalButabarbital Sodium (see all 8)125-40-6targetpotentiator14579514 10209232 11264449 17139284 11752352 17016423 10487207
    Butethal5-Butyl-5-ethyl-2,4,6(1H,3H,5H)-pyrimidinetrione (see all 10)77-28-1targetpotentiator14579514 10209232 11264449 17139284 11752352 17016423 10487207
    Metharbital-- 50-11-3targetpotentiator14579514 10209232 11264449 17139284 11752352 17016423 10487207
    PhenobarbitalFenobarbital (see all 7)50-06-6targetpotentiator14579514 10209232 11264449 17139284 17016423 10487207 2871724

    Selected IUPHAR Ligands for GABRA1 (alpha1) (see all 39)    About this table
    LigandTypeActionAffinityPubmed IDs
    piperidine-4-sulphonic acid
    AgonistFull agonist--
    5alpha-pregnan-3alpha-ol-20-one
    Allosteric regulatorPotentiation--
    [3H]flunitrazepam
    NoneNone--
    [35S]TBPS
    NoneNone--
    TPA023
    Allosteric regulatorAntagonist--
    [3H]muscimol
    NoneNone--
    isoguvacine
    AgonistFull agonist--
    Zn2+
    Allosteric regulatorInhibition--
    isonipecotic acid
    AgonistAgonist--
    [11C]flumazenil
    NoneNone--

    1 Novoseek inferred chemical compound relationship for GABRA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gaba 63.4 11 14706423 (2), 16569738 (1), 19294962 (1), 9861645 (1) (see all 8)

    3 PharmGKB related drug/compound annotations for GABRA1 gene    About this table
    Drug/compound PharmGKB Annotation
    carbamazepineCA  
    phenytoinCA  
    valproic acidCA  



    Find genes that share compounds with GABRA1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GABRA1 gene (7 alternative transcripts): 
    NM_000806.5  NM_001127643.1  NM_001127644.1  NM_001127645.1  NM_001127648.1  NM_001127646.1  NM_001127647.1  

    Unigene Cluster for GABRA1:

    Gamma-aminobutyric acid (GABA) A receptor, alpha 1
    Hs.175934  [show with all ESTs]
    Unigene Representative Sequence: NM_001127644
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000023897 ENST00000428797(uc010jiw.3 uc010jix.3 uc010jiy.3)
    ENST00000393943 ENST00000437025(uc003lyx.4) ENST00000521339 ENST00000522651
    ENST00000519621 ENST00000519542 ENST00000420560(uc010jiz.3 uc010jjb.3)
    ENST00000444819(uc010jja.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GABRA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GABRA1 (see all 48):
    hsa-miR-3607-3p hsa-miR-4272 hsa-miR-938 hsa-miR-3658 hsa-miR-208b hsa-miR-208a hsa-miR-155 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidGABRA1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GABRA1
    Predesigned siRNA for gene silencing in human, mouse, rat GABRA1
    Clone
    Products:
         
    OriGene clones in human, mouse for GABRA1 (see all 38)
    OriGene ORF clones in mouse, rat for GABRA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): GABRA1 (NM_000806)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GABRA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GABRA1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GABRA1
    OriGene qSTAR qPCR primer pairs in human, mouse for GABRA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GABRA1
      QuantiTect SYBR Green Assays in human, mouse, rat GABRA1
      QuantiFast Probe-based Assays in human, mouse, rat GABRA1
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11703) for GABRA1 

    Additional mRNA sequence: 

    AK223447.1 AK289792.1 AK295160.1 BC030696.1 X13584.1 X14766.1 

    8 DOTS entries:

    DT.110046  DT.305404  DT.120805196  DT.40190690  DT.40288455  DT.95080053  DT.95178057  DT.120805171 

    Selected AceView cDNA sequences (see all 43):

    Z44933 BM927274 BM687883 NM_000806 BC030696 Z40095 Z40687 F03552 
    F07280 BP359883 CK002884 AV722228 BX508303 BP346633 X14766 AA325450 
    Z44058 AL119816 BV203238 BP361506 CB155732 BP348789 AW005315 AV708951 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GABRA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTGCTTTA
    GABRA1 Expression
    About this image


    GABRA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neurons
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Testis (Reproductive System)
    GABRA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GABRA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.175934
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GABRA1: 
              Neurotransmitter Receptors in human mouse rat
              GABA & Glutamate in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GABRA1
    OriGene qSTAR qPCR primer pairs in human, mouse for GABRA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GABRA1
    QuantiTect SYBR Green Assays in human, mouse, rat GABRA1
    QuantiFast Probe-based Assays in human, mouse, rat GABRA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABRA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for GABRA1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gabra11 , 5 gamma-aminobutyric acid (GABA) A receptor, subunit more1, 5 91.65(n)1
    98.68(a)1
      11 (24.97 cM)5
    143941  NM_010250.51  NP_034380.11 
     421309395 
    chicken
    (Gallus gallus)
    Aves GABRA11 gamma-aminobutyric acid (GABA) A receptor, alpha 1 84.18(n)
    96.04(a)
      374214  NM_204318.2  NP_989649.1 
    lizard
    (Anolis carolinensis)
    Reptilia GABRA16
    gamma-aminobutyric acid (GABA) A receptor, alpha 1...
    92(a)
    1 ↔ 1
    1(106836985-106877561)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gabra11 gamma-aminobutyric acid (GABA) A receptor, alpha 1 75.35(n)
    84.11(a)
      100490334  XM_002941636.2  XP_002941682.2 
    zebrafish
    (Danio rerio)
    Actinopterygii gabra11 gamma-aminobutyric acid (GABA) A receptor, alpha 1 77.65(n)
    88.56(a)
      768183  NM_001077326.1  NP_001070794.1 


    ENSEMBL Gene Tree for GABRA1 (if available)
    TreeFam Gene Tree for GABRA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GABRA1 gene
    GABRG22  GABRE2  GABRA22  GABRA62  GABRA42  GABRG12  GABRA52  GABRG32  
    GABRA32  
    Selected SIMAP similar genes for GABRA1 using alignment to 4 protein entries:     GBRA1_HUMAN (see all proteins) (see all similar genes):
    GABRA2    GABRA5    GABRA3    GABRA4    GABRA6    GABRG3
    GABRE    GABRG1    GABRG2    GLRA4    GABRP    GLRA1
    GABRB1    GLRA2    GLRA3    GABRR2    DKFZp781L0846    GABRB3

    Find genes that share paralogs with GABRA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GABRA1 (see all 1246)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0136424
    Juvenile myoclonic epilepsy 5 (EJM5)4--see VAR_0136422 A D mis40--------
    rs719681321,2
    C--156390361(+) TGCTC-/TGTGTGTGT
    GTGTGTGTGTG
    TGTGT
    5 -- int10--------
    rs718272931,2
    C--156395596(+) ATTCA-/ATTATAT 5 -- int10--------
    rs613137081,2
    C--161284994(+) AAAAA-/AGGAAA 5 -- int10--------
    rs105876601,2
    C--161291851(+) ataaa-/ATAAA 
            
    tataa
    5 -- int11Minor allele frequency- ATAAA:0.00NA 2
    rs665568411,2
    C--161297953(-) CCAGT-/CACACAC 5 -- int11Minor allele frequency- CA:0.00NA 2
    rs113523671,2
    C--161313355(+) TATGG-/TTTTTT 5 -- int1 trp31Minor allele frequency- T:0.00CSA 2
    rs30781091,2
    C--161319679(+) ACAAA-/CAAA  
            
    AACAA
    5 -- int10--------
    rs1500575301,2
    --161500754(+) TTGGAG/TTTGCA 1 -- us2k10--------
    rs358356161,2
    C,F--161500765(+) TTTTAG/ATGTGG 1 -- us2k13Minor allele frequency- A:0.06NA WA 122

    HapMap Linkage Disequilibrium report for GABRA1 (161274197 - 161326975 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for GABRA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2533707CNV Deletion19546169
    esv34078CNV Loss18971310
    nsv883074CNV Loss21882294

    Human Gene Mutation Database (HGMD): GABRA1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GABRA1
    DNA2.0 Custom Variant and Variant Library Synthesis for GABRA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 137160   
    OMIM disorders: 611136  
    UniProtKB/Swiss-Prot: GBRA1_HUMAN, P14867
  • Epilepsy, childhood absence 4 (ECA4) [MIM:611136]: A subtype of idiopathic generalized epilepsy
    characterized by an onset at age 6-7 years, frequent absence seizures (several per day) and bilateral,
    synchronous, symmetric 3-Hz spike waves on EEG. Tonic-clonic seizures often develop in adolescence. Absence
    seizures may either remit or persist into adulthood. Note=Disease susceptibility is associated with variations
    affecting the gene represented in this entry
  • Juvenile myoclonic epilepsy 5 (EJM5) [MIM:611136]: A subtype of idiopathic generalized epilepsy. Patients
    have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which
    usually occur after awakening and are triggered by sleep deprivation and fatigue. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry

  • 11 diseases for GABRA1:    
    About MalaCards
    epilepsy, childhood absence, susceptibility to, 4    epileptic encephalopathy, early infantile, 19    epilepsy, juvenile myoclonic 5    gabra1-related juvenile myoclonic epilepsy
    childhood absence epilepsy    epilepsy, juvenile myoclonic 8    juvenile myoclonic epilepsy    early myoclonic encephalopathy
    juvenile absence epilepsy    epilepsy, childhood absence, susceptibility to, 2    dravet syndrome

    3 diseases from the University of Copenhagen DISEASES database for GABRA1:
    Juvenile absence epilepsy     Idiopathic generalized epilepsy     Early myoclonic encephalopathy

    Find genes that share disorders with GABRA1           About GenesLikeMe

    5 Novoseek inferred disease relationships for GABRA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myoclonic epilepsy juvenile 88.7 5 14631097 (1), 20308251 (1), 16839746 (1), 17008177 (1) (see all 5)
    childhood absence epilepsy 84.9 5 20308251 (1), 17008177 (1), 8739126 (1)
    epilepsy 54.2 3 20308251 (1), 17008177 (1), 18180303 (1)
    mood disorders 40.1 5 14706423 (3), 9861645 (1), 12946574 (1)
    bipolar disorder 29 2 14706423 (2)

    Genetic Association Database (GAD): GABRA1
    Human Genome Epidemiology (HuGE) Navigator: GABRA1 (32 documents)

    Export disorders for GABRA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GABRA1 gene, integrated from 10 sources (see all 202):
    (articles sorted by number of sources associating them with GABRA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Allelic variants of the gamma-aminobutyric acid-A receptor alpha1-subunit gene (GABRA1) are not associated with idiopathic gonadotropin-dependent precocious puberty in girls with and without electroencephalographic abnormalities. (PubMed id 16569738)1, 4, 9 Brito V.N....Latronico A.C. (J. Clin. Endocrinol. Metab. 2006)
    2. Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia. (PubMed id 16172613)1, 4, 9 Petryshen T.L....Sklar P. (Mol. Psychiatry 2005)
    3. Possible association between a haplotype of the GABA-A receptor alpha 1 subunit gene (GABRA1) and mood disorders. (PubMed id 14706423)1, 4, 9 Horiuchi Y....Arinami T. (Biol. Psychiatry 2004)
    4. Mutations in the GABRA1 and EFHC1 genes are rare in familial juvenile myoclonic epilepsy. (PubMed id 16839746)1, 4, 9 Ma S....Hedera P. (Epilepsy Res. 2006)
    5. Absence of GABRA1 Ala322Asp mutation in juvenile myoclonic epilepsy families from India. (PubMed id 14631097)1, 4, 9 Kapoor A....Anand A. (J. Genet. 2003)
    6. Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population. (PubMed id 17440936)1, 4, 9 Loh E.W....Stadlin A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    7. Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder. (PubMed id 20583128)1, 4 Green E.K....Craddock N. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    8. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    9. Association of alpha subunit of GABAA receptor subtype gene polymorphisms with epilepsy susceptibility and drug resistance in north Indian population. (PubMed id 20356767)1, 4 Kumari R....Mittal B. (Seizure 2010)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2554 HGNC: 4075 AceView: GABRA1 Ensembl:ENSG00000022355 euGenes: HUgn2554
    ECgene: GABRA1 Kegg: 2554 H-InvDB: GABRA1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GABRA1 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/056

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GABRA1 gene:
    Search GeneIP for patents involving GABRA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of GABRA1
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for GABRA1 (GABA-A R alpha 1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for GABRA1 (GABA-A R alpha 1)   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for GABRA1  
     OriGene qPCR primer pairs and template standards for GABRA1   OriGene Protein Over-expression Lysate for GABRA1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GABRA1  
     OriGene qSTAR qPCR primer pairs in human, mouse for GABRA1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GABRA1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GABRA1   OriGene Custom Protein Services for GABRA1  

     
     
     Block miRNA regulation of human, mouse, rat GABRA1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GABRA1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GABRA1 Predesigned siRNA for gene silencing in human, mouse, rat GABRA1
     QuantiFast Probe-based Assays in human, mouse, rat GABRA1 QuantiTect SYBR Green Assays in human, mouse, rat GABRA1
     PCR Arrays including human, mouse, rat GABRA1 Search Chromatin IP Primers for GABRA1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GABRA1  Search GeneGlobe Interaction Network for GABRA1
     Regulatory tfbs in GABRA1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for GABRA1 GenScript cDNA clones with any tag delivered in your preferred vector for GABRA1
     GenScript Custom Assay Services for GABRA1 GenScript Custom overexpressing Cell Line Services for GABRA1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for GABRA1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for GABRA1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GABRA1 antibodies
     GABRA1 proteins
     GABRA1 lysates
     Antibodies for GABRA1
     See all of Abcam's Antibodies, Kits and Proteins for GABRA1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for GABRA1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABRA1
     SwitchGear 3'UTR luciferase reporter plasmids for GABRA1
     SwitchGear Promoter luciferase reporter plasmids for GABRA1
     ThermoFisher Antibodies for GABRA1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GABRA1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GABRA1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GABRA1
     LSBio Antibodies in human, mouse, rat for GABRA1
     Browse compounds at ApexBio
     Search Addgene for plasmids for GABRA1
      Search eBioscience for proteins for GABRA1
      Search eBioscience for elisas for GABRA1
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for GABRA1 (79 products)
     antibodies-online kits for GABRA1 (5 products)
     antibodies-online peptides for GABRA1
     antibodies-online proteins for GABRA1 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GABRA1 gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4