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GABPB2 Gene

protein-coding GIFtS: 51

GC01P149310

GA binding protein transcription factor, beta subunit 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
GABPB-2 ^³
MGC29891 ^¹, ²
OTTHUMP00000014044 ^²

Descriptions
GA binding protein transcription factor, beta subunit 2 ^²
GA repeat binding protein, beta 2 ^²
GABP subunit beta-2 ^³

External Ids
HGNC: 28441¹
Entrez Gene: 126626²
UniProtKB: Q8TAK5³
Ensembl: ENSG00000143458⁷

Search outside databases for aliases for GABPB2 gene

Previous GC identifers: GC15U990021 GC15M048148 GC15M048285 GC15M048356

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: GABP2_HUMAN, Q8TAK5

Function: May function as transcription factor capable of interacting with purine rich repeats (GA

repeats) (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GABPB2 gene

Entrez Gene cytogenetic band: 1q21.2 Ensembl cytogenetic band: 1q21.2 HGNC cytogenetic band: 1q21.2

GABPB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P149310: (about GC identifiers)

Start:	149,309,704 bp from pter
End:	149,359,035 bp from pter
Size:	49,332 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: GABP2_HUMAN, Q8TAK5 (See protein sequence)

Recommended Name: GA-binding protein subunit beta-2

Size: 448 amino acids; 48650 Da

Subcellular location: Nucleus (By similarity)

Secondary accessions: B1AVJ8 Q8NAR5

REFSEQ proteins: NP_653219.1

ENSEMBL proteins:

ENSP00000357914 ENSP00000357913 ENSP00000357912

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MGC29891, GABPB2)
	Human Recombinant Proteins from Abnova (MGC29891)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

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Antibodies for GABPB2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for GABPB2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (MGC29891, GABPB2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MGC29891)
	Novus Biologicals Antibodies for GABPB2

Assays for GABPB2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8TAK5

ProtoNet protein and cluster: Q8TAK5

1 Blocks protein family: IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: GABP2_HUMAN, Q8TAK5

Similarity: Contains 5 ANK repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GABPB2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MGC29891)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_144618

Applied Biosystems Silencer® siRNAs for GABPB2

Sigma-Aldrich siRNA for GABPB2

Sigma-Aldrich shRNA for GABPB2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GABPB2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_144618
Myc/DDK tagged cDNA clone in CMV expression vector: NM_144618
untagged cDNA clone in CMV expression vector: NM_144618

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_144618

UniProtKB/Swiss-Prot: GABP2_HUMAN, Q8TAK5

Function: May function as transcription factor capable of interacting with purine rich repeats (GA

repeats) (By similarity)

Genatlas biochemistry entry for GABPB2:

GA binding protein,beta subunit 2,component of the nuclear respiratory factor 2,interacting with

GABPA form a high affinity DNA-binding complex recognizing an important site for herpes simplex

virus type I activation,putatively involved in the activation of nuclear genes specifying

mitochondrial function

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Gabpb2):

hematopoietic system

immune system

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

4 Interacting proteins for GABPB2 (ENSP00000357914³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
A1BG	ENSP00000263100³	STRING (score=.848)
TFAM	ENSP00000363006³	STRING (score=.813)
UTRN	ENSP00000356515³	STRING (score=.765)
SNORA7A	ENSP00000339064³	STRING (score=.713)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GABPB2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GABPB2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MGC29891)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_144618

Sigma-Aldrich siRNA for GABPB2

Sigma-Aldrich shRNA for GABPB2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_144618

REFSEQ mRNAs for GABPB2 gene:

NM_144618.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_144618

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_144618
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_144618
                                 untagged cDNA clone in CMV expression vector: NM_144618

Additional cDNA sequence:

AK301882.1 AK313606.1 BC027033.1 CR626488.1

9 DOTS entries:

DT.95116492 DT.100019491 DT.100858243 DT.100713368 DT.40284588 DT.40297557 DT.100742314 DT.121380225

DT.97822116

24/51 AceView cDNA sequences (see all 51 ):

AA558917 BU159847 AI912646 BE326219 BM505529 BU783136 AV703007 CR626488

CN480026 N50214 BG565858 BU783382 AK092230 BX348952 AW517236 BU663909

AW401441 BX360072 BM263838 BX359697 AI434754 NM_144618 BF854458 BX351958

highest scoring ESTs for GABPB2:

D13317 U13045 CB990559 AL708792 AU279507 AV660047 AV660333 BC016910 BC036080 BC050702

Unigene Cluster for GABPB2:

GA binding protein transcription factor, beta subunit 2

Hs.654699 [show with all ESTs]

Unigene Representative Sequence: BC027033

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GABPB2 (see all 7 )

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11
SP1:							-		-		-						-		-
SP2:							-		-		-				-
SP3:							-		-
SP4:
SP5:									-		-				-

About this scheme

ECgene alternative splicing isoforms for GABPB2

3 Ensembl transcripts including schematic representations:

ENST00000368918 ENST00000368917 ENST00000368916

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GABPB2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GABPB2

¹ / ² / ³

1 probe-set matching GABPB2 gene

	Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
	Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
	80227_at²	U95-D	1	0.88	1.00	1.00	1.00	--	--	--	--	--

GeneDecks GABPB2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGACACCCC

SOURCE GeneReport for Unigene cluster: Hs.654699
Expression variation in blood from EXPOLDB for GABPB2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GABPB2 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GABPB1¹	--	GA binding protein transcription factor, beta subunit more	89.22(n) 90.3(a)	475841 XM_845380.1 XP_850473.1
chimpanzee (Pan troglodytes)	GABPB1¹	--	GA binding protein transcription factor, beta subunit more	99.55(n) 99.33(a)	457284 XM_513786.2 XP_513786.2
cow (Bos taurus)	GABPB1¹	--	GA binding protein transcription factor, beta subunit more	92.08(n) 92.16(a)	540818 NM_001076242.1 NP_001069710.1
rat (Rattus norvegicus)	Gabpb2¹	--	GA binding protein transcription factor, beta subunit more	84.25(n) 85.16(a)	295263 XM_227439.4 XP_227439.4
mouse (Mus musculus)	Gabpb2^{1, 5}	3 (42.70 cM)⁵	GA repeat binding protein, beta 2^{1, 5}	86.34(n)¹ 85.37(a)¹	213054¹ NM_029885.1¹ NP_084161.1¹ AK007509⁵ AK029363⁵ (see all 24)

About this table Species with no ortholog for GABPB2

ENSEMBL Gene Tree for GABPB2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GABPB2 gene

ANKRD39² GABPB1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/281 NCBI SNPs in GABPB2 are shown (see all 281 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 41)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4970998^1,2	A,C,F,H	149357805(+)	`AGGGAG/AGTTAG`	1	--	ut3¹ trp³		8		EU EA WA	838
	rs11204774^1,2	C,F,H	149329581(+)	`CAGGTG/ATTAGC`	1	I/V	mis¹		12		EU EA WA	1252
	rs12039048^1,2	F,H	149308365(+)	`ATTGGG/ACAGTG`	1	--	ng5¹		2		EU WA	206
	rs16832988^1,2	F,H	149309850(+)	`CTTCAT/GTTCCG`	1	--	ut5¹ ese³		7		NA EU EA WA	558
--	rs6702344^1,2	A,C	149358710(+)	`gcacaC/Tgcctg`	1	--	ut3¹ ese³		0	--	--	--	--
	rs7537292^1,2	A,C,F,H	149337662(+)	`CTAGAC/GCAAAA`	1	--	int¹		4		EU EA WA	418
	rs6676190^1,2	A,C,F,H	149345941(+)	`AAATAT/CTGTTC`	1	--	int¹		4		EU EA WA	416
--	rs4970941^1,2	A,C,F,H	149335170(+)	`ATCCAG/AAGAAT`	1	--	int¹		4		EU EA WA	412
--	rs6656450^1,2	A,C,F,H	149356226(+)	`ATATTT/AAAAAT`	1	--	int¹		4		EU EA WA	412
--	rs1112193^1,2	A,C,F,H	149335988(-)	`AATAGT/CCTAAA`	1	--	int¹		11		EU EA WA NA	980

About this table

HapMap Linkage Disequilibrium images for GABPB2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for GABPB2 gene:

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Molecular and genetic characterization of GABP beta. (PubMed id 7958862)^{2, 3} de la Brousse F.C....McKnight S.L. (1994)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)⁴ Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 126626	HGNC: 28441	AceView: MGC29891	Ensembl:ENSG00000143458	euGenes: HUgn126626
ECgene: GABPB2	H-InvDB: GABPB2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for GABPB2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GABPB2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GABPB2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GABPB2		Antibodies for GABPB2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GABPB2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (MGC29891)
	Antibodies (MGC29891)
	Chimera RNAi (MGC29891)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (MGC29891, GABPB2)
	Antibodies (MGC29891, GABPB2)

Search OriGene for GABPB2

Search Tocris compounds for GABPB2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GABPB2

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GABPB2 Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for GABPB2

Summaries
for GABPB2

Genomic Location
for GABPB2

Proteins
for GABPB2

Protein Domains/
Families
for GABPB2

Gene Function
for GABPB2

Pathways & Interactions
for GABPB2

Drugs & Compounds
for GABPB2

Transcripts
for GABPB2

Expression
for GABPB2

Orthologs
for GABPB2

Paralogs
for GABPB2

SNPs/Variants
for GABPB2

Disorders & Mutations
for GABPB2

Medical News
for GABPB2

Publications
for GABPB2

Search for GABPB2

Genome Databases showing GABPB2

Other Databases showing GABPB2

Specialized Databases showing GABPB2

Licensable Technologies
for GABPB2

Services
for GABPB2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GABPB2 Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor GABPB2

Summariesfor GABPB2

Genomic Locationfor GABPB2

Proteinsfor GABPB2

Protein Domains/Familiesfor GABPB2

Gene Functionfor GABPB2

Pathways & Interactionsfor GABPB2

Drugs & Compoundsfor GABPB2

Transcriptsfor GABPB2

Expression for GABPB2

Orthologsfor GABPB2

Paralogsfor GABPB2

SNPs/Variantsfor GABPB2

Disorders & Mutationsfor GABPB2

Medical Newsfor GABPB2

Publicationsfor GABPB2

Search for GABPB2

Genome Databases showing GABPB2

Other Databases showing GABPB2

Specialized Databases showing GABPB2

Licensable Technologiesfor GABPB2

Servicesfor GABPB2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GABPB2

Summaries
for GABPB2

Genomic Location
for GABPB2

Proteins
for GABPB2

Protein Domains/
Families
for GABPB2

Gene Function
for GABPB2

Pathways & Interactions
for GABPB2

Drugs & Compounds
for GABPB2

Transcripts
for GABPB2

Expression
for GABPB2

Orthologs
for GABPB2

Paralogs
for GABPB2

SNPs/Variants
for GABPB2

Disorders & Mutations
for GABPB2

Medical News
for GABPB2

Publications
for GABPB2

Licensable Technologies
for GABPB2

Services
for GABPB2