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Aliases for GABPB2 Gene

Aliases for GABPB2 Gene

  • GA Binding Protein Transcription Factor Beta Subunit 2 2 3 5
  • GABP Subunit Beta-2 3 4
  • GABPB-2 3 4
  • GA-Binding Protein Subunit Beta-2 3

External Ids for GABPB2 Gene

Previous GeneCards Identifiers for GABPB2 Gene

  • GC15U990021
  • GC15M048148
  • GC15M048285
  • GC15M048356
  • GC01P149310
  • GC01P122420

Summaries for GABPB2 Gene

GeneCards Summary for GABPB2 Gene

GABPB2 (GA Binding Protein Transcription Factor Beta Subunit 2) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and transcription regulatory region DNA binding. An important paralog of this gene is GABPB1-IT1.

UniProtKB/Swiss-Prot for GABPB2 Gene

  • May function as transcription factor capable of interacting with purine rich repeats (GA repeats).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GABPB2 Gene

Genomics for GABPB2 Gene

Regulatory Elements for GABPB2 Gene

Enhancers for GABPB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G151970 1.6 Ensembl ENCODE dbSUPER 130.2 +898.6 898635 0.4 PKNOX1 FOXA2 SIN3A ZNF2 ZNF416 FOS ZNF548 ZNF662 REST ZNF624 GABPB2 MRPL9 LYSMD1 ENSG00000229021 HRNR S100A10 PSMB4 THEM5 RN7SL444P S100A11
GH01G151940 2 FANTOM5 Ensembl ENCODE dbSUPER 99.7 +873.5 873520 7.6 FOXA2 PKNOX1 SIN3A FEZF1 ZNF2 ZBTB7B ZNF416 FOS DEK SP3 GABPB2 LYSMD1 MRPL9 THEM4 ENSG00000229021 FLG-AS1 PSMB4 RN7SL444P HRNR C1orf56
GH01G151933 1.9 FANTOM5 Ensembl ENCODE dbSUPER 52.6 +865.2 865164 3.6 AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 GABPB2 MRPL9 ENSG00000229021 THEM4 HRNR S100A10 LINGO4 THEM5 RPS10P6 C1orf56
GH01G151308 2 FANTOM5 Ensembl ENCODE dbSUPER 28.7 +241.4 241359 6.1 CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MRPL9 GABPB2 SETDB1 GOLPH3L LYSMD1 PRPF3 UBE2D3P3 ZNF687 ADAMTSL4 RFX5
GH01G151789 1.2 ENCODE 42.4 +720.2 720231 1.9 CREB3L1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NFYC TBX21 ZNF610 MRPL9 GABPB2 SETDB1 UBE2D3P3 OAZ3 ENSG00000232937 CTSK RPS10P6 ENSG00000229021 FLG-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GABPB2 on UCSC Golden Path with GeneCards custom track

Promoters for GABPB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000013579 322 1801 CREB3L1 AGO1 FEZF1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 TBX21

Genomic Location for GABPB2 Gene

Chromosome:
1
Start:
151,070,578 bp from pter
End:
151,129,119 bp from pter
Size:
58,542 bases
Orientation:
Plus strand

Genomic View for GABPB2 Gene

Genes around GABPB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GABPB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GABPB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GABPB2 Gene

Proteins for GABPB2 Gene

  • Protein details for GABPB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAK5-GABP2_HUMAN
    Recommended name:
    GA-binding protein subunit beta-2
    Protein Accession:
    Q8TAK5
    Secondary Accessions:
    • B1AVJ8
    • D3DV14
    • Q8NAR5

    Protein attributes for GABPB2 Gene

    Size:
    448 amino acids
    Molecular mass:
    48650 Da
    Quaternary structure:
    • Heterotetramer of two alpha and two beta subunits. The C-terminal is necessary for the formation of a heterotetrameric GABP-alpha-2/beta-2 complex, and also facilitates homotypic dimerization. Interacts with ADGRB2.

neXtProt entry for GABPB2 Gene

Post-translational modifications for GABPB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GABPB2 Gene

Domains & Families for GABPB2 Gene

Gene Families for GABPB2 Gene

Protein Domains for GABPB2 Gene

Suggested Antigen Peptide Sequences for GABPB2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GABPB2: view

No data available for UniProtKB/Swiss-Prot for GABPB2 Gene

Function for GABPB2 Gene

Molecular function for GABPB2 Gene

GENATLAS Biochemistry:
GA binding protein,beta subunit 2,component of the nuclear respiratory factor 2,interacting with GABPA form a high affinity DNA-binding complex recognizing an important site for herpes simplex virus type I activation,putatively involved in the activation of nuclear genes specifying mitochondrial function
UniProtKB/Swiss-Prot Function:
May function as transcription factor capable of interacting with purine rich repeats (GA repeats).

Gene Ontology (GO) - Molecular Function for GABPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0042803 protein homodimerization activity IEA --
GO:0044212 transcription regulatory region DNA binding IDA 9857059
GO:0046982 protein heterodimerization activity IDA 9857059
genes like me logo Genes that share ontologies with GABPB2: view
genes like me logo Genes that share phenotypes with GABPB2: view

Animal Model Products

CRISPR Products

miRNA for GABPB2 Gene

miRTarBase miRNAs that target GABPB2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GABPB2 Gene

Localization for GABPB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GABPB2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GABPB2 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for GABPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9857059
genes like me logo Genes that share ontologies with GABPB2: view

Pathways & Interactions for GABPB2 Gene

SuperPathways for GABPB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GABPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 9857059
genes like me logo Genes that share ontologies with GABPB2: view

No data available for Pathways by source and SIGNOR curated interactions for GABPB2 Gene

Drugs & Compounds for GABPB2 Gene

No Compound Related Data Available

Transcripts for GABPB2 Gene

Unigene Clusters for GABPB2 Gene

GA binding protein transcription factor, beta subunit 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GABPB2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4:
SP5: - - -
SP6: -
SP7: - - -

Relevant External Links for GABPB2 Gene

GeneLoc Exon Structure for
GABPB2
ECgene alternative splicing isoforms for
GABPB2

Expression for GABPB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GABPB2 Gene

Protein differential expression in normal tissues from HIPED for GABPB2 Gene

This gene is overexpressed in Liver, secretome (28.6), Peripheral blood mononuclear cells (10.0), CD4 Tcells (9.3), Lymph node (7.2), and CD8 Tcells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GABPB2 Gene



Protein tissue co-expression partners for GABPB2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GABPB2 Gene:

GABPB2

SOURCE GeneReport for Unigene cluster for GABPB2 Gene:

Hs.654699
genes like me logo Genes that share expression patterns with GABPB2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GABPB2 Gene

Orthologs for GABPB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GABPB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GABPB2 34 35
  • 99.55 (n)
cow
(Bos Taurus)
Mammalia GABPB2 34 35
  • 91.01 (n)
dog
(Canis familiaris)
Mammalia GABPB2 34 35
  • 90.09 (n)
mouse
(Mus musculus)
Mammalia Gabpb2 34 16 35
  • 86.18 (n)
rat
(Rattus norvegicus)
Mammalia Gabpb2 34
  • 85.32 (n)
oppossum
(Monodelphis domestica)
Mammalia GABPB2 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GABPB2 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 80 (a)
OneToMany
-- 35
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia GABPB2 35
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii gabpb2b 34 35
  • 64.29 (n)
gabpb2a 35
  • 57 (a)
OneToMany
Dr.16630 34
fruit fly
(Drosophila melanogaster)
Insecta Atac3 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for GABPB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GABPB2 Gene

ENSEMBL:
Gene Tree for GABPB2 (if available)
TreeFam:
Gene Tree for GABPB2 (if available)

Paralogs for GABPB2 Gene

Paralogs for GABPB2 Gene

(5) SIMAP similar genes for GABPB2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GABPB2: view

Variants for GABPB2 Gene

Sequence variations from dbSNP and Humsavar for GABPB2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000052352 -- 151,080,571(+) GGCCA(A/G)GTACA intron-variant
rs1000082523 -- 151,094,136(+) AGCCT(C/T)CATTT intron-variant
rs1000101679 -- 151,086,793(+) CTCCT(A/G)AGTAG intron-variant, upstream-variant-2KB
rs1000140490 -- 151,069,110(+) ATAAA(C/T)GAATT upstream-variant-2KB
rs1000156130 -- 151,071,936(+) CTTTT(C/T)CCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GABPB2 Gene

Variant ID Type Subtype PubMed ID
esv3587519 CNV loss 21293372
nsv1113178 CNV deletion 24896259
nsv1113179 CNV deletion 24896259
nsv472328 CNV novel sequence insertion 20440878
nsv522840 CNV gain 19592680

Variation tolerance for GABPB2 Gene

Residual Variation Intolerance Score: 74.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.47; 88.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GABPB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GABPB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GABPB2 Gene

Disorders for GABPB2 Gene

Relevant External Links for GABPB2

Genetic Association Database (GAD)
GABPB2
Human Genome Epidemiology (HuGE) Navigator
GABPB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GABPB2

No disorders were found for GABPB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GABPB2 Gene

Publications for GABPB2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Molecular and genetic characterization of GABP beta. (PMID: 7958862) de la Brousse F.C. … McKnight S.L. (Genes Dev. 1994) 2 3 64
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64

Products for GABPB2 Gene

Sources for GABPB2 Gene

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