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Aliases for GABPB2 Gene

Aliases for GABPB2 Gene

  • GA Binding Protein Transcription Factor Beta Subunit 2 2 3
  • GA Binding Protein Transcription Factor, Beta Subunit 2 3 5
  • GABP Subunit Beta-2 3 4
  • GABPB-2 3 4

External Ids for GABPB2 Gene

Previous GeneCards Identifiers for GABPB2 Gene

  • GC15U990021
  • GC15M048148
  • GC15M048285
  • GC15M048356
  • GC01P149310
  • GC01P122420

Summaries for GABPB2 Gene

GeneCards Summary for GABPB2 Gene

GABPB2 (GA Binding Protein Transcription Factor Beta Subunit 2) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and transcription regulatory region DNA binding. An important paralog of this gene is ANKRD39.

UniProtKB/Swiss-Prot for GABPB2 Gene

  • May function as transcription factor capable of interacting with purine rich repeats (GA repeats).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GABPB2 Gene

Genomics for GABPB2 Gene

Regulatory Elements for GABPB2 Gene

Promoters for GABPB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GABPB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GABPB2 Gene

Chromosome:
1
Start:
151,070,578 bp from pter
End:
151,129,119 bp from pter
Size:
58,542 bases
Orientation:
Plus strand

Genomic View for GABPB2 Gene

Genes around GABPB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GABPB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GABPB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GABPB2 Gene

Proteins for GABPB2 Gene

  • Protein details for GABPB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAK5-GABP2_HUMAN
    Recommended name:
    GA-binding protein subunit beta-2
    Protein Accession:
    Q8TAK5
    Secondary Accessions:
    • B1AVJ8
    • D3DV14
    • Q8NAR5

    Protein attributes for GABPB2 Gene

    Size:
    448 amino acids
    Molecular mass:
    48650 Da
    Quaternary structure:
    • Heterotetramer of two alpha and two beta subunits. The C-terminal is necessary for the formation of a heterotetrameric GABP-alpha-2/beta-2 complex, and also facilitates homotypic dimerization. Interacts with ADGRB2.

neXtProt entry for GABPB2 Gene

Proteomics data for GABPB2 Gene at MOPED

Post-translational modifications for GABPB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GABPB2 Gene

Domains & Families for GABPB2 Gene

Gene Families for GABPB2 Gene

Protein Domains for GABPB2 Gene

Suggested Antigen Peptide Sequences for GABPB2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TAK5

UniProtKB/Swiss-Prot:

GABP2_HUMAN :
  • Contains 5 ANK repeats.
Similarity:
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with GABPB2: view

Function for GABPB2 Gene

Molecular function for GABPB2 Gene

GENATLAS Biochemistry:
GA binding protein,beta subunit 2,component of the nuclear respiratory factor 2,interacting with GABPA form a high affinity DNA-binding complex recognizing an important site for herpes simplex virus type I activation,putatively involved in the activation of nuclear genes specifying mitochondrial function
UniProtKB/Swiss-Prot Function:
May function as transcription factor capable of interacting with purine rich repeats (GA repeats).

Gene Ontology (GO) - Molecular Function for GABPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IEA --
GO:0044212 transcription regulatory region DNA binding IDA 9857059
genes like me logo Genes that share ontologies with GABPB2: view
genes like me logo Genes that share phenotypes with GABPB2: view

Animal Model Products

miRNA for GABPB2 Gene

miRTarBase miRNAs that target GABPB2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GABPB2 Gene

Localization for GABPB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GABPB2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GABPB2 Gene COMPARTMENTS Subcellular localization image for GABPB2 gene
Compartment Confidence
nucleus 5
cytosol 4

No data available for Gene Ontology (GO) - Cellular Components for GABPB2 Gene

Pathways & Interactions for GABPB2 Gene

SuperPathways for GABPB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GABPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 9857059
genes like me logo Genes that share ontologies with GABPB2: view

No data available for Pathways by source and SIGNOR curated interactions for GABPB2 Gene

Drugs & Compounds for GABPB2 Gene

No Compound Related Data Available

Transcripts for GABPB2 Gene

Unigene Clusters for GABPB2 Gene

GA binding protein transcription factor, beta subunit 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GABPB2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4:
SP5: - - -
SP6: -
SP7: - - -

Relevant External Links for GABPB2 Gene

GeneLoc Exon Structure for
GABPB2
ECgene alternative splicing isoforms for
GABPB2

Expression for GABPB2 Gene

mRNA expression in normal human tissues for GABPB2 Gene

Protein differential expression in normal tissues from HIPED for GABPB2 Gene

This gene is overexpressed in Liver, secretome (28.6), Peripheral blood mononuclear cells (10.0), CD4 Tcells (9.3), Lymph node (7.2), and CD8 Tcells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GABPB2 Gene



SOURCE GeneReport for Unigene cluster for GABPB2 Gene Hs.654699

genes like me logo Genes that share expression patterns with GABPB2: view

Protein tissue co-expression partners for GABPB2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GABPB2 Gene

Orthologs for GABPB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GABPB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GABPB2 35
  • 91.01 (n)
  • 90.44 (a)
GABPB2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GABPB2 35
  • 90.09 (n)
  • 90.09 (a)
GABPB2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gabpb2 35
  • 86.18 (n)
  • 85.12 (a)
Gabpb2 16
Gabpb2 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GABPB2 35
  • 99.55 (n)
  • 99.33 (a)
GABPB2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gabpb2 35
  • 85.32 (n)
  • 86.86 (a)
oppossum
(Monodelphis domestica)
Mammalia GABPB2 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GABPB2 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 80 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia GABPB2 36
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Dr.16630 35
gabpb2b 35
  • 64.29 (n)
  • 67.52 (a)
gabpb2a 36
  • 57 (a)
OneToMany
gabpb2b 36
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Atac3 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for GABPB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GABPB2 Gene

ENSEMBL:
Gene Tree for GABPB2 (if available)
TreeFam:
Gene Tree for GABPB2 (if available)

Paralogs for GABPB2 Gene

Paralogs for GABPB2 Gene

(5) SIMAP similar genes for GABPB2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GABPB2: view

Variants for GABPB2 Gene

Sequence variations from dbSNP and Humsavar for GABPB2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11204774 - 151,090,481(+) CAGGT(A/G)TTAGC intron-variant, reference, missense
rs1112193 -- 151,096,888(-) AATAG(C/T)CTAAA intron-variant
rs2864699 -- 151,073,048(+) AGCGT(C/G)TTGCT intron-variant, utr-variant-5-prime
rs3034035 -- 151,070,178(+) ttttt(-/AAAA/AAAAA/AAAAAAAAAAAAA/TTTT)gagac upstream-variant-2KB
rs4360524 -- 151,127,081(+) CACTC(A/G)GCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GABPB2 Gene

Variant ID Type Subtype PubMed ID
nsv522840 CNV Gain 19592680
nsv872421 CNV Loss 21882294

Variation tolerance for GABPB2 Gene

Residual Variation Intolerance Score: 74.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.47; 88.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GABPB2 Gene

HapMap Linkage Disequilibrium report
GABPB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GABPB2 Gene

Disorders for GABPB2 Gene

Relevant External Links for GABPB2

Genetic Association Database (GAD)
GABPB2
Human Genome Epidemiology (HuGE) Navigator
GABPB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GABPB2

No disorders were found for GABPB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GABPB2 Gene

Publications for GABPB2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Molecular and genetic characterization of GABP beta. (PMID: 7958862) de la Brousse F.C. … McKnight S.L. (Genes Dev. 1994) 2 3
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for GABPB2 Gene

Sources for GABPB2 Gene

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