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Aliases for GABPB1 Gene

Aliases for GABPB1 Gene

  • GA Binding Protein Transcription Factor Beta Subunit 1 2 3
  • GA Binding Protein Transcription Factor, Beta Subunit 1 3 5
  • Transcription Factor E4TF1-47 3 4
  • Transcription Factor E4TF1-53 3 4
  • Nuclear Respiratory Factor 2 3 4
  • GABP Subunit Beta-2 3 4
  • GABPB-1 3 4
  • E4TF1B 3 4
  • GABPB2 3 4
  • GABPB 3 4
  • GA Binding Protein Transcription Factor Beta Subunit 1 Transcript Variant Gamma-2 3
  • GA Binding Protein Transcription Factor, Beta Subunit 2 2
  • GABP Subunit Beta-1 4
  • E4TF1-47 3
  • E4TF1-53 3
  • GABPB-2 4
  • BABPB2 3
  • NRF2B1 3
  • NRF2B2 3
  • E4TF1 3

External Ids for GABPB1 Gene

Previous HGNC Symbols for GABPB1 Gene

  • GABPB2

Previous GeneCards Identifiers for GABPB1 Gene

  • GC15M046126
  • GC15M043615
  • GC15M048358
  • GC15M050569
  • GC15M027400

Summaries for GABPB1 Gene

Entrez Gene Summary for GABPB1 Gene

  • This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GABPB1 Gene

GABPB1 (GA Binding Protein Transcription Factor Beta Subunit 1) is a Protein Coding gene. Among its related pathways are Myometrial Relaxation and Contraction Pathways and Organelle biogenesis and maintenance. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is ANKRD39.

UniProtKB/Swiss-Prot for GABPB1 Gene

  • Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.

Gene Wiki entry for GABPB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GABPB1 Gene

Genomics for GABPB1 Gene

Regulatory Elements for GABPB1 Gene

Promoters for GABPB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GABPB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GABPB1 Gene

Chromosome:
15
Start:
50,275,392 bp from pter
End:
50,355,408 bp from pter
Size:
80,017 bases
Orientation:
Minus strand

Genomic View for GABPB1 Gene

Genes around GABPB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GABPB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GABPB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GABPB1 Gene

Proteins for GABPB1 Gene

  • Protein details for GABPB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06547-GABP1_HUMAN
    Recommended name:
    GA-binding protein subunit beta-1
    Protein Accession:
    Q06547
    Secondary Accessions:
    • A8IE52
    • Q06545
    • Q12940
    • Q12941
    • Q12942
    • Q8IYD0

    Protein attributes for GABPB1 Gene

    Size:
    395 amino acids
    Molecular mass:
    42483 Da
    Quaternary structure:
    • Heterotetramer of two alpha and two beta subunits. Interacts with HCFC1, causing repression of transcriptional activity.

    Alternative splice isoforms for GABPB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GABPB1 Gene

Proteomics data for GABPB1 Gene at MOPED

Post-translational modifications for GABPB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GABPB1 Gene

Domains & Families for GABPB1 Gene

Gene Families for GABPB1 Gene

Protein Domains for GABPB1 Gene

Suggested Antigen Peptide Sequences for GABPB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q06547

UniProtKB/Swiss-Prot:

GABP1_HUMAN :
  • Contains 5 ANK repeats.
Similarity:
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with GABPB1: view

Function for GABPB1 Gene

Molecular function for GABPB1 Gene

GENATLAS Biochemistry:
GA binding protein,beta subunit 1,component of the nuclear respiratory factor 1,interacting with GABPA to form a high affinity DNA-binding complex recognizing an important site for herpes simplex virus type I activation,putatively involved in the activation of nuclear genes specifying mitochondrial function
UniProtKB/Swiss-Prot Function:
Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.

Gene Ontology (GO) - Molecular Function for GABPB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 10675337
GO:0044212 transcription regulatory region DNA binding IDA 9857059
genes like me logo Genes that share ontologies with GABPB1: view
genes like me logo Genes that share phenotypes with GABPB1: view

Animal Models for GABPB1 Gene

MGI Knock Outs for GABPB1:

Animal Model Products

miRNA for GABPB1 Gene

miRTarBase miRNAs that target GABPB1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GABPB1 Gene

Localization for GABPB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GABPB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GABPB1 Gene COMPARTMENTS Subcellular localization image for GABPB1 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 3
cytoskeleton 2

No data available for Gene Ontology (GO) - Cellular Components for GABPB1 Gene

Pathways & Interactions for GABPB1 Gene

genes like me logo Genes that share pathways with GABPB1: view

Pathways by source for GABPB1 Gene

Gene Ontology (GO) - Biological Process for GABPB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0007005 mitochondrion organization TAS --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 9857059
genes like me logo Genes that share ontologies with GABPB1: view

No data available for SIGNOR curated interactions for GABPB1 Gene

Drugs & Compounds for GABPB1 Gene

No Compound Related Data Available

Transcripts for GABPB1 Gene

Unigene Clusters for GABPB1 Gene

GA binding protein transcription factor, beta subunit 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GABPB1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5: -
SP6:
SP7:

Relevant External Links for GABPB1 Gene

GeneLoc Exon Structure for
GABPB1
ECgene alternative splicing isoforms for
GABPB1

Expression for GABPB1 Gene

mRNA expression in normal human tissues for GABPB1 Gene

Protein differential expression in normal tissues from HIPED for GABPB1 Gene

This gene is overexpressed in Pancreas (41.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GABPB1 Gene



SOURCE GeneReport for Unigene cluster for GABPB1 Gene Hs.654350

genes like me logo Genes that share expression patterns with GABPB1: view

Protein tissue co-expression partners for GABPB1 Gene

- Elite partner

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GABPB1 Gene

Orthologs for GABPB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GABPB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GABPB1 35
  • 99.83 (n)
  • 100 (a)
GABPB1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GABPB1 36
  • 100 (a)
OneToOne
GABPB1 35
  • 95.3 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia GABPB1 35
  • 95.11 (n)
  • 100 (a)
GABPB1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gabpb1 16
Gabpb1 35
  • 91.62 (n)
  • 98.17 (a)
Gabpb1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GABPB1 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GABPB1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gabpb1l 35
  • 91.04 (n)
  • 98.69 (a)
chicken
(Gallus gallus)
Aves GABPB1 35
  • 85.55 (n)
  • 97.65 (a)
GABPB1 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GABPB1 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gabpb1 35
  • 82.68 (n)
  • 95.82 (a)
zebrafish
(Danio rerio)
Actinopterygii GABPB1 36
  • 54 (a)
OneToOne
gabpb1 35
  • 66.47 (n)
  • 74.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta Atac3 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for GABPB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GABPB1 Gene

ENSEMBL:
Gene Tree for GABPB1 (if available)
TreeFam:
Gene Tree for GABPB1 (if available)

Paralogs for GABPB1 Gene

Paralogs for GABPB1 Gene

genes like me logo Genes that share paralogs with GABPB1: view

Variants for GABPB1 Gene

Sequence variations from dbSNP and Humsavar for GABPB1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_035613 A colorectal cancer sample
rs12470 -- 50,277,864(-) GTTCT(A/C)GGAAG utr-variant-3-prime
rs12923 -- 50,277,839(-) ATAAC(C/T)TGAAT utr-variant-3-prime
rs1365504 -- 50,298,983(+) gaaaA(A/G)AAAAA intron-variant
rs1797311 -- 50,312,620(+) AGTAC(A/G)GTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GABPB1 Gene

Variant ID Type Subtype PubMed ID
nsv819649 CNV Loss 19587683
esv275353 CNV Loss 21479260
esv2749679 CNV Deletion 23290073
esv2087264 CNV Deletion 18987734
esv2749680 CNV Deletion 23290073

Variation tolerance for GABPB1 Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GABPB1 Gene

HapMap Linkage Disequilibrium report
GABPB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GABPB1 Gene

Disorders for GABPB1 Gene

Relevant External Links for GABPB1

Genetic Association Database (GAD)
GABPB1
Human Genome Epidemiology (HuGE) Navigator
GABPB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GABPB1

No disorders were found for GABPB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GABPB1 Gene

Publications for GABPB1 Gene

  1. Interaction between SNPs in the NRF2 gene and elite endurance performance. (PMID: 20028934) Eynon N. … Meckel Y. (Physiol. Genomics 2010) 3 23 48 67
  2. Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain. (PMID: 7799916) Gugneja S. … Scarpulla R.C. (Mol. Cell. Biol. 1995) 3 23
  3. Molecular and genetic characterization of GABP beta. (PMID: 7958862) de la Brousse F.C. … McKnight S.L. (Genes Dev. 1994) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for GABPB1 Gene

Sources for GABPB1 Gene

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