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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GABPB1 Gene

protein-coding   GIFtS: 53
GCID: GC15M050569

GA binding protein transcription factor, beta subunit 1

(Previous names: GA binding protein transcription factor, beta subunit 2...)
(Previous symbol: GABPB2)
 Explore 6 diseases affiliated with
GABPB1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GABPB1    

Aliases
for GABPB1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
GA Binding Protein Transcription Factor, Beta Subunit 11 2     BABPB22 5
GABPB1 2 3 5     NRF2B12 5
GABPB21 2 3     GA Binding Protein Transcription Factor, Beta Subunit 21
E4TF1B2 3 5     E4TF12
E4TF1-471 2     E4TF1-532
Nuclear Respiratory Factor 22 3     NRF2B22
Transcription Factor E4TF1-472 3     GA Binding Protein Transcription Factor Beta Subunit 1 Transcript Variant
Gamma-22
Transcription Factor E4TF1-532 3     GA-Binding Protein Subunit Beta-12
GABPB-12 3     GABPB-23
GABP Subunit Beta-22 3     GABP Subunit Beta-13

External Ids:    HGNC: 40741   Entrez Gene: 25532   Ensembl: ENSG000001040647   OMIM: 6006105   UniProtKB: Q065473   

Export aliases for GABPB1 gene to outside databases

Previous GC identifers: GC15M046126 GC15M043615 GC15M048358 GC15M027400


Summaries
for GABPB1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GABPB1:
This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex
with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in
activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a
similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding
distinct isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GABP1_HUMAN, Q06547
Function: Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the
expression of the Adenovirus E4 gene

Gene Wiki entry for GABPB1 (GABPB2)


Genomic Views
for GABPB1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GABPB1 gene promoter:
         AhR   Tal-1   MEF-2   RREB-1   Lmo2   c-Ets-1   E47   MEF-2A   FOXC1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GABPB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GABPB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GABPB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q21.2

GABPB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GABPB1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M050569:  view genomic region     (about GC identifiers)

Start:
 50,569,389 bp from pter      End:
 50,647,605 bp from pter
Size:
 78,217 bases      Orientation:
 minus strand

Proteins
for GABPB1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GABP1_HUMAN, Q06547 (See protein sequence)
Recommended Name: GA-binding protein subunit beta-1  
Size: 395 amino acids; 42483 Da
Subunit: Heterotetramer of two alpha and two beta subunits. Interacts with HCFC1, causing repression of transcriptional
activity
Subcellular location: Nucleus
Secondary accessions: A8IE52 Q06545 Q12940 Q12941 Q12942 Q8IYD0
Alternative splicing: 4 isoforms:  Q06547-1   Q06547-2   Q06547-3   Q06547-4   

Explore the universe of human proteins at neXtProt for GABPB1: NX_Q06547

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q06547

    • GABPB1 Protein expression data from MOPED and PaxDb:    About this image 
    GABPB1 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_002032.2  NP_005245.2  NP_057738.1  NP_057739.1  NP_852092.1  

    ENSEMBL proteins: 
     ENSP00000370259   ENSP00000220429   ENSP00000442500   ENSP00000453806   ENSP00000395771  
     ENSP00000379728   ENSP00000453463   ENSP00000453578   ENSP00000454211   ENSP00000351923  

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    Novus Biologicals GABPB1 Lysates
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9857059

    GABPB1 for ontologies           About GeneDecksing



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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for GABPB1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GABPB1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q06547

    ProtoNet protein and cluster: Q06547

    1 Blocks protein family: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: GABP1_HUMAN, Q06547
    Similarity: Contains 5 ANK repeats


    Function
    for GABPB1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GABP1_HUMAN, Q06547
    Function: Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the
    expression of the Adenovirus E4 gene

         Genatlas biochemistry entry for GABPB1:
    GA binding protein,beta subunit 1,component of the nuclear respiratory factor 1,interacting with GABPA to form a high
    affinity DNA-binding complex recognizing an important site for herpes simplex virus type I activation,putatively
    involved in the activation of nuclear genes specifying mitochondrial function

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8441384
    GO:0005515protein binding IPI10675337
    GO:0044212transcription regulatory region DNA binding IDA9857059
    GO:0046982protein heterodimerization activity IDA9857059
         
    GABPB1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for GABPB1:
     Increased S DNA content  Increased gamma-H2AX phosphory  S arrest  Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Gabpb1):
     behavior/neurological  immune system  mortality/aging  muscle  nervous system 

    GABPB1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for GABPB1: Gabpb1tm1Hhx Gabpb1tm2Hhx
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for GABPB1 

    miRNA
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    hsa-miR-3607-3p hsa-miR-4328 hsa-miR-106a hsa-miR-374a* hsa-miR-93 hsa-miR-526b* hsa-miR-3163 hsa-miR-20a
    SwitchGear 3'UTR luciferase reporter plasmid: GABPB1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for GABPB1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Calcium Regulation in the Cardiac Cell
    		Myometrial Relaxation and Contraction Pathways0.43


    1 BioSystems Pathway for GABPB1 
        Myometrial Relaxation and Contraction Pathways


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GABPB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/18 Interacting proteins for GABPB1 (Q065471, 2, 3 ENSP000003702594) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CICQ96RK02, 3, ENSP000001607404MINT-2859081 I2D: score=3 STRING: ENSP00000160740
    HCFC1P516101, 3, ENSP000003095554EBI-618189,EBI-2832627 I2D: score=3 STRING: ENSP00000309555
    BAI2O602412, 3, ENSP000003627624MINT-75010 I2D: score=2 STRING: ENSP00000362762
    MAGEB18Q96M611, 3, ENSP000003145434EBI-618165,EBI-741835 I2D: score=3 STRING: ENSP00000314543
    FANCGO152873, ENSP000003679104I2D: score=4 STRING: ENSP00000367910
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS8441384
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA9857059

    GABPB1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GABPB1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GABPB1
    Search CenterWatch for drugs/clinical trials and news about GABPB1 / GABP1 

    Transcripts
    for GABPB1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GABPB1 gene (5 alternative transcripts): 
    NM_002041.4  NM_005254.5  NM_016654.4  NM_016655.4  NM_181427.3  

    Unigene Cluster for GABPB1:

    GA binding protein transcription factor, beta subunit 1
    Hs.654350  [show with all ESTs]
    Unigene Representative Sequence: NM_005254
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380877(uc001zya.3 uc001zyb.3 uc010ufg.2) ENST00000220429
    ENST00000543881 ENST00000561010 ENST00000429662 ENST00000396464 ENST00000560825
    ENST00000559100 ENST00000558335 ENST00000558970 ENST00000560896(uc001zyg.3)
    ENST00000359031(uc001zyc.3 uc001zyd.3 uc001zye.3 uc001zyf.3)


    miRNA
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    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate GABPB1 (see all 38):
    hsa-miR-3607-3p hsa-miR-4328 hsa-miR-106a hsa-miR-374a* hsa-miR-93 hsa-miR-526b* hsa-miR-3163 hsa-miR-20a
    SwitchGear 3'UTR luciferase reporter plasmid: GABPB1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GABPB1 (see all 4)
    OriGene shRNA RFP: GABPB1
    OriGene siRNA: GABPB1
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    Sirion Biotech Custom design and validation of potent shRNA sequences against GABPB1 
    Clone
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    Additional cDNA sequence: 

    AK301350.1 AK303901.1 BC016910.1 BC036080.1 BC050702.1 BT006652.1 D13316.1 D13317.1 
    EU159454.1 JQ313901.1 U13045.1 U13046.1 U13047.1 U13048.1 

    13 DOTS entries:

    DT.97823854  DT.100688291  DT.100796128  DT.95271555  DT.100796127  DT.453073  DT.121078254  DT.121078274 
    DT.121078225  DT.121078283  DT.121078268  DT.121078313  DT.446655 

    24/196 AceView cDNA sequences (see all 196):

    BQ050762 AI183417 BQ186620 AA599554 U13047 AA665626 AU131804 NM_016655 
    BC068063 AI636537 BQ430343 AW003076 AI468623 BT006652 BC016910 BM684569 
    W38337 CR591958 BM469386 AI475518 BM550715 CA416618 CD237056 NM_016654 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GABPB1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10
    SP1:                    -                                   -                       -     -         
    SP2:                    -                                                           -     -         
    SP3:                    -                                   -                                       
    SP4:                    -                                                                           
    SP5:                                                        -                                       


    ECgene alternative splicing isoforms for GABPB1

    Expression
    for GABPB1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GABPB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    GABPB1 Expression
    About this image
    See GABPB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GABPB1

    SOURCE GeneReport for Unigene cluster: Hs.654350
        SABiosciences Custom PCR Arrays for GABPB1

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABPB1

    Orthologs
    for GABPB1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for GABPB1 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Gabpb11 , 5 GA repeat binding protein, beta 11, 5 91.62(n)1
    98.17(a)1    		   2 (61.76 cM)5
    143911  NM_207669.11  NP_997552.11 
     1266274425 
    chicken
    (Gallus gallus)    		 Aves GABPB11 GA binding protein transcription factor, beta subunit more 85.55(n)
    97.65(a)    		   415453  NM_001012622.1  NP_001012640.1 
    lizard
    (Anolis carolinensis)    		 Reptilia GABPB16
    --
    		 --
    		 95(a)
    26(a)
    		 1 ↔ 1
    possible ortholog
    		 GL343747.1(49374-58913)
    5(142662462-142698297)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC046663.12   -- 80.84(n)    BC046663.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii gabpb11 GA binding protein transcription factor, beta subunit more 65.51(n)
    74.06(a)    		   768285  NM_001077450.1  NP_001070918.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Atac36
    		 ATAC complex component 3
    		 17(a)
    		 1 → many
    		 3L(324985-327992)


    ENSEMBL Gene Tree for GABPB1 (if available)
    TreeFam Gene Tree for GABPB1 (if available) 

    Paralogs
    for GABPB1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GABPB1 gene
    GABPB22  
    18/39 SIMAP similar genes for GABPB1 using alignment to 5 protein entries:     GABP1_HUMAN (see all proteins) (see all similar genes):
    GABPB2    ANK1    ANKRD28    IkBa    ANK3    ANKRD12
    ANKRD42    ANK2    ANKRD6    ASB3    EHMT1    MTMR8
    ANKHD1    ANKRD29    ANKRD61    ANKRD65    TNKS    TRPA1

    GABPB1 for paralogs           About GeneDecksing



    Genomic Variants
    for GABPB1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1288 NCBI SNPs in GABPB1 are shown (see all 1288)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs286688851,2
    		C,F--27399954(+) TGTACC/TGAAGT 2 -- ds50011Minor allele frequency- T:0.14WA 118
    rs727389031,2
    		C--27400100(+) AAAAAG/AATCTT 2 -- ds50012Minor allele frequency- A:0.07CSA NA 122
    rs18026621,2
    		H--27400511(-) TATTGC/ATTTAT 2 -- ut314Minor allele frequency- A:0.00NS EA 420
    rs745020551,2
    		C--27400567(+) TTACCC/AAAAAA 2 -- ut311Minor allele frequency- A:0.50NA 2
    rs10505711,2
    		C,F,O,H--27401304(-) AGGAAA/GTCTTT 2 -- ut3115Minor allele frequency- G:0.03NA NS EA CSA 1108
    rs287098391,2
    		C--27401393(+) ACATTT/AGGCCT 2 -- ut313Minor allele frequency- A:0.14NA WA 122
    rs357734901,2
    		C--27401935(+) GAGGGT/-TTTTT 2 -- int11Minor allele frequency- -:0.00CSA 2
    rs113063611,2
    		C,F--27402613(+) TGATTA/-AATTA 2 -- int15Minor allele frequency- -:0.40NA CSA 10
    rs801305941,2
    		--27403060(+) CTTGAC/TTCCTG 2 -- int11Minor allele frequency- T:0.01WA 118
    rs116355461,2
    		C,F,A,H--27405494(+) tagccG/Aggtat 2 -- int114Minor allele frequency- A:0.06NS EA NA 1832

    HapMap Linkage Disequilibrium report for GABPB1 (50569389 - 50647605 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for GABPB1
         1 CNV: 58726
         1 Indel: 45346

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    Disorders / Diseases
    for GABPB1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GABPB1 for disorders           About GeneDecksing

    OMIM gene information: 600610    OMIM disorders: --

    6 diseases for GABPB1:    About MalaCards
    adenylosuccinate lyase deficiency    herpes simplex    multiple sclerosis    retinoblastoma
    ataxia    cholesterol

    Human Genome Epidemiology (HuGE) Navigator: GABPB1 (3 documents)

    Export disorders for GABPB1 gene to outside databases

    Publications
    for GABPB1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GABPB1 gene, integrated from 9 sources (see all 57):
    (articles sorted by number of sources associating them with GABPB1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain. (PubMed id 7799916)1, 2, 9 Gugneja S.... Scarpulla R.C. (1995)
    2. The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP. (PubMed id 10675337)1, 2 Vogel J.L. and Kristie T.M. (2000)
    3. Nuclear respiratory factors 1 and 2 utilize similar glutamine- containing clusters of hydrophobic residues to activate transcription. (PubMed id 8816484)1, 2 Gugneja S.... Scarpulla R.C. (1996)
    4. Molecular and genetic characterization of GABP beta. (PubMed id 7958862)1, 3 de la Brousse F.C....McKnight S.L. (1994)
    5. Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters. (PubMed id 8383622)1, 2 Virbasius J.V.... Scarpulla R.C. (1993)
    6. cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs. (PubMed id 8441384)1, 2 Watanabe H.... Handa H. (1993)
    7. Interaction between SNPs in the NRF2 gene and elite e ndurance performance. (PubMed id 20028934)1, 9 Eynon N....Meckel Y. (2010)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for GABPB1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing GABPB1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2553 HGNC: 4074 AceView: GABPB2 Ensembl:ENSG00000104064 euGenes: HUgn2553
    ECgene: GABPB1 H-InvDB: GABPB1

    Other Databases showing GABPB1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GABPB1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GABPB1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for GABPB1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GABPB1 gene:
    Search GeneIP for patents involving GABPB1

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