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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GABPB1 Gene

protein-coding   GIFtS: 57
GCID: GC15M050569

GA Binding Protein Transcription Factor, Beta Subunit 1

(Previous names: GA binding protein transcription factor, beta subunit 2)
(Previous symbol: GABPB2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
GA Binding Protein Transcription Factor, Beta Subunit 11 2     NRF2B12 5
GABPB21 2 3     GA Binding Protein Transcription Factor, Beta Subunit 21
E4TF1B2 3 5     E4TF12
GABPB2 3 5     E4TF1-472
Nuclear Respiratory Factor 22 3     E4TF1-532
Transcription Factor E4TF1-472 3     NRF2B22
Transcription Factor E4TF1-532 3     GA Binding Protein Transcription Factor Beta Subunit 1 Transcript Variant
Gamma-22
GABPB-12 3     GA-Binding Protein Subunit Beta-12
GABP Subunit Beta-22 3     GABPB-23
BABPB22 5     GABP Subunit Beta-13

External Ids:    HGNC: 40741   Entrez Gene: 25532   Ensembl: ENSG000001040647   OMIM: 6006105   UniProtKB: Q065473   

Export aliases for GABPB1 gene to outside databases

Previous GC identifers: GC15M046126 GC15M043615 GC15M048358 GC15M027400


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GABPB1 Gene:
This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric
complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved
in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal
structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript
variants encoding distinct isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for GABPB1 Gene: 
GABPB1 (GA binding protein transcription factor, beta subunit 1) is a protein-coding gene. Diseases associated with GABPB1 include adenylosuccinate lyase deficiency, and herpes simplex, and among its related super-pathways are Calcium Regulation in the Cardiac Cell. GO annotations related to this gene include transcription regulatory region DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ANKRD39.

UniProtKB/Swiss-Prot: GABP1_HUMAN, Q06547
Function: Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the
expression of the Adenovirus E4 gene

Gene Wiki entry for GABPB1 (GABPB2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GABPB1 gene promoter:
         AhR   Tal-1   MEF-2   RREB-1   Lmo2   c-Ets-1   E47   MEF-2A   FOXC1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGABPB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GABPB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GABPB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q21.2

GABPB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GABPB1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M050569:  view genomic region     (about GC identifiers)

Start:
50,569,389 bp from pter      End:
50,647,605 bp from pter
Size:
78,217 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GABP1_HUMAN, Q06547 (See protein sequence)
Recommended Name: GA-binding protein subunit beta-1  
Size: 395 amino acids; 42483 Da
Subunit: Heterotetramer of two alpha and two beta subunits. Interacts with HCFC1, causing repression of
transcriptional activity
Subcellular location: Nucleus
Secondary accessions: A8IE52 Q06545 Q12940 Q12941 Q12942 Q8IYD0
Alternative splicing: 4 isoforms:  Q06547-1   Q06547-2   Q06547-3   Q06547-4   

Explore the universe of human proteins at neXtProt for GABPB1: NX_Q06547

Explore proteomics data for GABPB1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q06547

  • GABPB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GABPB1 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_002032.2  NP_005245.2  NP_057738.1  NP_057739.1  NP_852092.1  

    ENSEMBL proteins: 
     ENSP00000370259   ENSP00000220429   ENSP00000442500   ENSP00000453806   ENSP00000395771  
     ENSP00000379728   ENSP00000453463   ENSP00000453578   ENSP00000454211   ENSP00000351923  

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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9857059

    GABPB1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q06547

    ProtoNet protein and cluster: Q06547

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: GABP1_HUMAN, Q06547
    Similarity: Contains 5 ANK repeats


    GABPB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GABP1_HUMAN, Q06547
    Function: Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the
    expression of the Adenovirus E4 gene

         Genatlas biochemistry entry for GABPB1:
    GA binding protein,beta subunit 1,component of the nuclear respiratory factor 1,interacting with GABPA to form a
    high affinity DNA-binding complex recognizing an important site for herpes simplex virus type I
    activation,putatively involved in the activation of nuclear genes specifying mitochondrial function

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8441384
    GO:0005515protein binding IPI10675337
    GO:0044212transcription regulatory region DNA binding IDA9857059
    GO:0046982protein heterodimerization activity IDA9857059
         
    GABPB1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for GABPB1:
     Increased S DNA content  Increased gamma-H2AX phosphory  S arrest  Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gabpb1):
     behavior/neurological  immune system  mortality/aging  muscle  nervous system 

    GABPB1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GABPB1: Gabpb1tm1Hhx Gabpb1tm2Hhx

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GABPB1 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GABPB1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways0.43


    1 BioSystems Pathway for GABPB1
        Myometrial Relaxation and Contraction Pathways


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GABPB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/18 Interacting proteins for GABPB1 (Q065471, 2, 3 ENSP000003702594) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CICQ96RK02, 3, ENSP000001607404MINT-2859081 I2D: score=3 STRING: ENSP00000160740
    HCFC1P516101, 3, ENSP000003095554EBI-618189,EBI-396176 I2D: score=3 STRING: ENSP00000309555
    BAI2O602412, 3, ENSP000003627624MINT-75010 I2D: score=2 STRING: ENSP00000362762
    MAGEB18Q96M611, 3, ENSP000003145434EBI-618165,EBI-741835 I2D: score=3 STRING: ENSP00000314543
    FANCGO152873, ENSP000003679104I2D: score=4 STRING: ENSP00000367910
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS8441384
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA9857059

    GABPB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GABPB1 (GABP1)

    Search CenterWatch for drugs/clinical trials and news about GABPB1 / GABP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GABPB1 gene (5 alternative transcripts): 
    NM_002041.4  NM_005254.5  NM_016654.4  NM_016655.4  NM_181427.3  

    Unigene Cluster for GABPB1:

    GA binding protein transcription factor, beta subunit 1
    Hs.654350  [show with all ESTs]
    Unigene Representative Sequence: NM_005254
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380877(uc001zya.3 uc001zyb.3 uc010ufg.2) ENST00000220429
    ENST00000543881 ENST00000561010 ENST00000429662 ENST00000396464 ENST00000560825
    ENST00000559100 ENST00000558335 ENST00000558970 ENST00000359031(uc001zyc.3 uc001zyd.3 uc001zye.3 uc001zyf.3)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    SwitchGear 3'UTR luciferase reporter plasmidGABPB1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK301350.1 AK303901.1 BC016910.1 BC036080.1 BC050702.1 BT006652.1 D13316.1 D13317.1 
    EU159454.1 JQ313901.1 U13045.1 U13046.1 U13047.1 U13048.1 

    13 DOTS entries:

    DT.97823854  DT.100688291  DT.100796128  DT.95271555  DT.100796127  DT.453073  DT.121078254  DT.121078274 
    DT.121078225  DT.121078283  DT.121078268  DT.121078313  DT.446655 

    24/196 AceView cDNA sequences (see all 196):

    AA599554 BU733511 AI803474 BQ421507 CD237056 U13048 BQ430343 AA136871 
    U13045 BU631828 AI468559 AI475518 BQ186620 NM_016654 NM_016655 BC068063 
    AI183417 AI804122 CR591958 BC050702 BM469386 AW003076 AU131804 AA764814 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GABPB1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10
    SP1:                    -                                   -                       -     -         
    SP2:                    -                                                           -     -         
    SP3:                    -                                   -                                       
    SP4:                    -                                                                           
    SP5:                                                        -                                       


    ECgene alternative splicing isoforms for GABPB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GABPB1 expression in normal human tissues (normalized intensities)      GABPB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GABPB1 Expression
    About this image


    GABPB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/38 selected tissues (see all 38) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             bone marrow cd34+   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See GABPB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GABPB1

    SOURCE GeneReport for Unigene cluster: Hs.654350
        SABiosciences Custom PCR Arrays for GABPB1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABPB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GABPB1 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gabpb11 , 5 GA repeat binding protein, beta 11, 5 91.62(n)1
    98.17(a)1
      2 (61.76 cM)5
    143911  NM_207669.11  NP_997552.11 
     1266274425 
    chicken
    (Gallus gallus)
    Aves GABPB11 GA binding protein transcription factor, beta subunit more 85.55(n)
    97.65(a)
      415453  NM_001012622.1  NP_001012640.1 
    lizard
    (Anolis carolinensis)
    Reptilia GABPB16
    Uncharacterized protein
    97(a)
    1 ↔ 1
    GL343747.1(46603-58913)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC046663.12   -- 80.84(n)    BC046663.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gabpb11 GA binding protein transcription factor, beta subunit more 65.51(n)
    74.06(a)
      768285  NM_001077450.1  NP_001070918.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Atac36
    ATAC complex component 3
    17(a)
    1 → many
    3L(324985-327992)


    ENSEMBL Gene Tree for GABPB1 (if available)
    TreeFam Gene Tree for GABPB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GABPB1 gene
    ANKRD392  GABPB22  
    18/40 SIMAP similar genes for GABPB1 using alignment to 5 protein entries:     GABP1_HUMAN (see all proteins) (see all similar genes):
    GABPB2    ANK1    ANKRD28    IkBa    ANK3    ANKRD12
    NOTCH3    ANKRD42    ANK2    ANKRD6    EHMT1    GPR75-ASB3
    MTMR8    ANKHD1    ANKRD29    ANKRD61    ANKRD65    TNKS

    GABPB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1528 SNPs in GABPB1 are shown (see all 1528)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356134
    A colorectal cancer sample4--see VAR_0356132 P A mis40--------
    rs589177961,2
    C,F--27399896(+) ACCACAT/-GTCAG 2 -- ds50012Minor allele frequency- -:0.50NA CSA 4
    rs113063611,2
    C,F--27402612(+) TGATTA/-AATTA 2 -- int15Minor allele frequency- -:0.40NA CSA 10
    rs2005713931,2
    C--27402613(+) TGATTA/TAATTA 2 -- int10--------
    rs113520591,2
    C--27412508(+) AAATTA/-AAAAA 5 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs343303391,2
    C--27412508(+) AAATT-/AAAAAA 5 -- int11Minor allele frequency- A:0.50NA 2
    rs1137713921,2
    C--27415916(+) GTATA-/TGTG/ 
    TGTGTGTG
    TGTGT
    5 -- int11CSA 2
    rs39858301,2
    C--27415940(+) TGTGT-/GT/GTGT
    /GTGTGTGT
    ACATG
    5 -- int10--------
    rs1410350471,2
    C--27416206(+) AACCA-/CTCTCTA 5 -- int10--------
    rs2012070851,2
    --27416211(+) CTCTC-/TACTAAA 5 -- int10--------

    HapMap Linkage Disequilibrium report for GABPB1 (50569389 - 50647605 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for GABPB1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2087264CNV Deletion18987734
    esv2749680CNV Deletion23290073
    esv2749679CNV Deletion23290073
    esv275353CNV Loss21479260
    nsv819649CNV Loss19587683

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600610    OMIM disorders: --

    5 diseases for GABPB1:    About MalaCards
    adenylosuccinate lyase deficiency    herpes simplex    retinoblastoma    multiple sclerosis
    neuronitis


    GABPB1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GABPB1
    Human Genome Epidemiology (HuGE) Navigator: GABPB1 (3 documents)

    Export disorders for GABPB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GABPB1 gene, integrated from 9 sources (see all 59):
    (articles sorted by number of sources associating them with GABPB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction between SNPs in the NRF2 gene and elite e ndurance performance. (PubMed id 20028934)1, 4, 9 Eynon N....Meckel Y. (2010)
    2. Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain. (PubMed id 7799916)1, 2, 9 Gugneja S.... Scarpulla R.C. (1995)
    3. The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP. (PubMed id 10675337)1, 2 Vogel J.L. and Kristie T.M. (2000)
    4. Nuclear respiratory factors 1 and 2 utilize similar glutamine- containing clusters of hydrophobic residues to activate transcription. (PubMed id 8816484)1, 2 Gugneja S.... Scarpulla R.C. (1996)
    5. Molecular and genetic characterization of GABP beta. (PubMed id 7958862)1, 3 de la Brousse F.C....McKnight S.L. (1994)
    6. Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters. (PubMed id 8383622)1, 2 Virbasius J.V.... Scarpulla R.C. (1993)
    7. cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs. (PubMed id 8441384)1, 2 Watanabe H.... Handa H. (1993)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2553 HGNC: 4074 AceView: GABPB2 Ensembl:ENSG00000104064 euGenes: HUgn2553
    ECgene: GABPB1 H-InvDB: GABPB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GABPB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GABPB1 gene:
    Search GeneIP for patents involving GABPB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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