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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GABPA Gene

protein-coding   GIFtS: 60
GCID: GC21P027106

GA Binding Protein Transcription Factor, Alpha Subunit 6...

(Previous names: GA-binding protein transcription factor, alpha subunit (6...)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
GA Binding Protein Transcription Factor, Alpha Subunit 60kDa1 2     E4TF1-602
E4TF1A2 3 5     NFT22
Human Nuclear Respiratory Factor-2 Subunit Alpha2 11     NRF22
Nuclear Respiratory Factor 2 Alpha Subunit1 2     NRF2A2
Nuclear Respiratory Factor 2 Subunit Alpha2 3     RCH04A072
Transcription Factor E4TF1-602 3     GA Binding Protein Transcription Factor Alpha Subunit 60kDa2
GABP Subunit Alpha2 3     GA-Binding Protein Alpha Chain2
GA-Binding Protein Transcription Factor, Alpha Subunit (60kD)1     

External Ids:    HGNC: 40711   Entrez Gene: 25512   Ensembl: ENSG000001547277   OMIM: 6006095   UniProtKB: Q065463   

Export aliases for GABPA gene to outside databases

Previous GC identifers: GC21P023686 GC21P026023 GC21P026029 GC21P026028 GC07P062691


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GABPA Gene:
This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding
subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is
likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function.
This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for
expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers
with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants
encoding the same protein have been found for this gene. (provided by RefSeq, Oct 2010)

GeneCards Summary for GABPA Gene: 
GABPA (GA binding protein transcription factor, alpha subunit 60kDa) is a protein-coding gene. Diseases associated with GABPA include complex regional pain syndrome, and noma, and among its related super-pathways are Calcium Regulation in the Cardiac Cell. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ELK4.

UniProtKB/Swiss-Prot: GABPA_HUMAN, Q06546
Function: Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the
expression of the Adenovirus E4 gene

Gene Wiki entry for GABPA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NT_011512.11  NC_018932.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GABPA gene promoter:
         TBP   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGABPA promoter sequence

   Search SABiosciences Chromatin IP Primers for GABPA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GABPA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.3   Ensembl cytogenetic band:  21q21.3   HGNC cytogenetic band: 21q21-q22.1
Nature(405: 311-319) cytogenetic band:   21q21.3
GABPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GABPA gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P027106:   GeneLoc Nature:405,311-319
Start:
27,106,881 bp from pter       12,685,464 bp from centromere
End:
27,144,771 bp from pter 12,719,695 bp from centromere
Size:
37,891 bases 34,232 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: U13044D13318
genomic clones: pT172


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GABPA_HUMAN, Q06546 (See protein sequence)
Recommended Name: GA-binding protein alpha chain  
Size: 454 amino acids; 51295 Da
Subunit: Heterotetramer of two alpha and two beta subunits
Subcellular location: Nucleus
Secondary accessions: Q12939

Explore the universe of human proteins at neXtProt for GABPA: NX_Q06546

Explore proteomics data for GABPA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q06546

  • GABPA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GABPA Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001184226.1  NP_002031.2  

    ENSEMBL proteins: 
     ENSP00000346886   ENSP00000382948  

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    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IDA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    GABPA for ontologies           About GeneDecksing



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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR000418 Ets_dom
     IPR024668 GABP_asu_N
     IPR011991 WHTH_DNA-bd_dom
     IPR003118 Pointed_dom
     IPR013761 SAM/pointed

    Graphical View of Domain Structure for InterPro Entry Q06546

    ProtoNet protein and cluster: Q06546

    1 Blocks protein domain: IPB003118 Sterile alpha motif (SAM)/Pointed domain

    UniProtKB/Swiss-Prot: GABPA_HUMAN, Q06546
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain
    Similarity: Contains 1 PNT (pointed) domain


    GABPA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GABPA_HUMAN, Q06546
    Function: Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the
    expression of the Adenovirus E4 gene

         Genatlas biochemistry entry for GABPA:
    GA binding protein,alpha subunit with an ETS related domain,component of the nuclear respiratory factor
    2,ubiquitously expressed,interacting with the four ankyrin-type repeats to form a high affinity DNA-binding
    complex recognizing an important site for herpes simplex virus type I activation,putatively involved in the
    activation of nuclear genes specifying mitochondrial function

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA--
    GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA--
    GO:0003677DNA binding TAS8441384
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS7590737
         
    GABPA for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GABPA:
     Decreased viability with pacli 

         11 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Gabpa):
     cellular  embryogenesis  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  muscle  nervous system  no phenotypic analysis 
     normal 

    GABPA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GABPA: Gabpatm1.1Sjb Gabpatm1Rist

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GABPA 
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    SwitchGear 3'UTR luciferase reporter plasmidGABPA 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GABPA About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways0.43
    2Agrin Interactions at Neuromuscular Junction
    Agrin Interactions at Neuromuscular Junction
    3Energy Metabolism
    Energy Metabolism

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for GABPA
        Agrin Interactions at Neuromuscular Junction

    2 BioSystems Pathways for GABPA
        Myometrial Relaxation and Contraction Pathways
    Energy Metabolism


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GABPA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/21 Interacting proteins for GABPA (Q065461, 2, 3 ENSP000003468864) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HCFC1P516101, 3, ENSP000003095554EBI-638925,EBI-396176 I2D: score=4 STRING: ENSP00000309555
    SP1P080472, 3, ENSP000003293574MINT-49851 MINT-49852 I2D: score=4 STRING: ENSP00000329357
    SP3Q024472, 3, ENSP000003103014MINT-49853 MINT-49854 I2D: score=4 STRING: ENSP00000310301
    GABPB1Q065473, ENSP000003702594I2D: score=4 STRING: ENSP00000370259
    ATF1P188463, ENSP000002620534I2D: score=3 STRING: ENSP00000262053
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006366transcription from RNA polymerase II promoter TAS8441384

    GABPA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GABPA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for GABPA

    9 Novoseek inferred chemical compound relationships for GABPA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tbhq 74.1 19 15525690 (5), 19174151 (2), 15582588 (1), 15923610 (1)
    diethylmaleate 57.5 7 15521073 (1), 17077087 (1), 15379550 (1)
    curcumin 37.6 4 17913594 (1), 17449203 (1), 15923610 (1)
    arsenite 35.5 3 15521073 (1), 18572023 (1), 12745069 (1)
    oxygen 23.4 7 19679692 (2), 17077087 (1), 18717629 (1), 20030899 (1)
    atp 0 3 1656236 (2), 12539966 (1)
    lipid 0 2 18230803 (1)
    calcium 0 2 12665481 (2)
    serine 0 1 7799916 (1)

    Search CenterWatch for drugs/clinical trials and news about GABPA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GABPA gene (2 alternative transcripts): 
    NM_001197297.1  NM_002040.3  

    Unigene Cluster for GABPA:

    GA binding protein transcription factor, alpha subunit 60kDa
    Hs.473470  [show with all ESTs]
    Unigene Representative Sequence: BX647755
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354828(uc002ylx.4) ENST00000400075(uc002yly.4) ENST00000487266


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    Additional mRNA sequence: 

    AK223164.1 AK313545.1 BC035031.2 BX647755.1 D13318.1 EU159453.1 JQ313900.1 U13044.1 
    X84366.1 

    15 DOTS entries:

    DT.99933995  DT.99992826  DT.100727081  DT.453987  DT.121138154  DT.121138106  DT.70101580  DT.121137994 
    DT.121138144  DT.437389  DT.449898  DT.92407558  DT.121079420  DT.121138049  DT.70104921 

    24/135 AceView cDNA sequences (see all 135):

    AA173607 BU683067 AI075824 CA392232 T93885 AU107260 AI684289 AA935134 
    BQ023312 BQ423139 BM974511 AI624911 AA730256 AA704298 BQ216320 BM477941 
    BI826069 AA946680 BM464174 BX647755 AI990899 AW105605 AA497016 NM_002040 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GABPA expression in normal human tissues (normalized intensities)      GABPA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAGTTTTT
    GABPA Expression
    About this image


    GABPA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Eye (Sensory Organs)
             Retina

    See GABPA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GABPA

    SOURCE GeneReport for Unigene cluster: Hs.473470
        SABiosciences Custom PCR Arrays for GABPA
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABPA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GABPA gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gabpa1 , 5 GA repeat binding protein, alpha1, 5 89.7(n)1
    96.25(a)1
      16 (46.92 cM)5
    143901  NM_008065.21  NP_032091.21 
     848349255 
    chicken
    (Gallus gallus)
    Aves GABPA1 GA binding protein transcription factor, alpha subunit more 82.12(n)
    93.38(a)
      418478  NM_001007858.1  NP_001007859.1 
    lizard
    (Anolis carolinensis)
    Reptilia GABPA6
    Uncharacterized protein
    94(a)
    1 ↔ 1
    3(148256363-148275005)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.346172 Xenopus laevis transcribed sequence with moderate similarity more 78.03(n)    BJ095846.1 
    zebrafish
    (Danio rerio)
    Actinopterygii e4tf2 E4tf1-60 transcription factor 74.07(n)   58110  AF257741.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ets97D1 , 3 DNA binding3
    Ets at 97D1
    38(a)3
    48.48(n)1
    42.17(a)1
      3 97D73
    432361  NM_079799.31  NP_524523.21 


    ENSEMBL Gene Tree for GABPA (if available)
    TreeFam Gene Tree for GABPA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GABPA gene
    ELK42  ETV12  ETV32  ERF2  ETV52  ETV3L2  ETS12  ETS22  
    ELK12  ERG2  FEV2  ETV42  ETV22  FLI12  ELK32  
    3 SIMAP similar genes for GABPA using alignment to 3 protein entries:     GABPA_HUMAN (see all proteins):
    GABPAP    FEV    ELK3

    GABPA for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GABPA
    PGOHUM00000233346


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/796 SNPs in GABPA are shown (see all 796)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1504576811,2
    --12508510(+) TGAAAA/GCAAAC 2 -- us2k10--------
    rs1899827161,2
    --12508512(+) AAAGCA/TAACTG 2 -- us2k10--------
    rs1383062981,2
    --12508519(+) ACTGTC/TTGAAG 2 -- us2k10--------
    rs1820134611,2
    --12508520(+) CTGTTC/TGAAGA 2 -- us2k10--------
    rs1492231751,2
    --12508694(+) GTGGTC/TGGGCG 2 -- us2k10--------
    rs1847442111,2
    --12508806(+) TCTCTA/TCTGAA 2 -- us2k10--------
    rs747714541,2
    F--12508834(+) AGGCAA/TGATGG 2 -- us2k11Minor allele frequency- T:0.33NA 6
    rs1891477531,2
    --12508842(+) GTGGCA/GGGCAC 2 -- us2k10--------
    rs748974001,2
    C--12508863(-) CCCGAG/ATAGCT 2 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1809268171,2
    --12508925(+) AGATCA/GTGCCA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for GABPA (27106881 - 27144771 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GABPA:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv913653CNV Loss21882294
    nsv913654CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600609    OMIM disorders: --

    20/23 diseases for GABPA (see all 23):    About MalaCards
    complex regional pain syndrome    noma    paine syndrome    down syndrome
    friedreich ataxia    cystic fibrosis    gastritis    intrahepatic cholangiocarcinoma
    ulcerative colitis    cholangiocarcinoma    herpes simplex    pulmonary fibrosis
    myopathy    ataxia    multiple sclerosis    obesity
    alcoholism    rheumatoid arthritis    arthritis    adenocarcinoma


    GABPA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for GABPA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurodegenerative diseases 28.9 2 18824091 (1), 18717629 (1)

    Genetic Association Database (GAD): GABPA
    Human Genome Epidemiology (HuGE) Navigator: GABPA (3 documents)

    Export disorders for GABPA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GABPA gene, integrated from 9 sources (see all 150):
    (articles sorted by number of sources associating them with GABPA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs. (PubMed id 8441384)1, 2, 3 Watanabe H.... Handa H. (1993)
    2. Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain. (PubMed id 7799916)1, 2, 9 Gugneja S.... Scarpulla R.C. (1995)
    3. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (2008)
    4. Nuclear respiratory factor 2 induces the expression o f many but not all human proteins acting in mitochondrial DNA transcription and replication. (PubMed id 19951946)1, 9 Bruni F....Roberti M. (2010)
    5. In vitro methylation of nuclear respiratory factor-2 binding sites suppresses the promoter activity of the human TOMM70 gene. (PubMed id 18852034)1, 9 Blesa J.R....Hernandez-Yago J. (2008)
    6. Identification of polymorphisms in the promoter region of the human NRF2 gene. (PubMed id 15358217)4, 9 Yamamoto T....Yamamoto M. (2004)
    7. Mapping of the human transcription factor GABPA (E4TF1-60) gene to chromosome 21. (PubMed id 7590737)1, 9 Chrast R....Antonarakis S.E. (1995)
    8. Human nuclear respiratory factor 2 alpha subunit cDNA: isolation, subcloning, sequencing, and in situ hybridization of transcripts in normal and monocularly deprived macaque visual system. (PubMed id 10660899)1, 9 Guo A....Wong-Riley M. (2000)
    9. Nuclear respiratory factor 2 activates transcription of human mitochondrial translation initiation factor 2 gene. (PubMed id 17161026)1, 9 Hayashi R....Takeuchi N. (2007)
    10. Activation of synoviolin promoter in rheumatoid synovial cells by a novel transcription complex of interleukin enhancer binding factor 3 and GA binding protein alpha. (PubMed id 19116932)1, 9 Izumi T....Nakajima T. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2551 HGNC: 4071 AceView: GABPA Ensembl:ENSG00000154727 euGenes: HUgn2551
    ECgene: GABPA H-InvDB: GABPA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GABPA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GABPA gene:
    Search GeneIP for patents involving GABPA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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