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Aliases for GABPA Gene

Aliases for GABPA Gene

  • GA Binding Protein Transcription Factor, Alpha Subunit 60kDa 2 3
  • E4TF1A 3 4 6
  • Human Nuclear Respiratory Factor-2 Subunit Alpha 2 3
  • Nuclear Respiratory Factor 2 Alpha Subunit 2 3
  • Nuclear Respiratory Factor 2 Subunit Alpha 3 4
  • Transcription Factor E4TF1-60 3 4
  • GABP Subunit Alpha 3 4
  • GA-Binding Protein Transcription Factor, Alpha Subunit (60kD) 2
  • GA Binding Protein Transcription Factor Alpha Subunit 60kDa 3
  • GA-Binding Protein Alpha Chain 3
  • E4TF1-60 3
  • RCH04A07 3
  • NRF2A 3
  • NFT2 3
  • NRF2 3

External Ids for GABPA Gene

Summaries for GABPA Gene

Entrez Gene Summary for GABPA Gene

  • This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for GABPA Gene

GABPA (GA Binding Protein Transcription Factor, Alpha Subunit 60kDa) is a Protein Coding gene. Diseases associated with GABPA include down syndrome. Among its related pathways are Agrin Interactions at Neuromuscular Junction and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is ETV2.

UniProtKB/Swiss-Prot for GABPA Gene

  • Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene

Gene Wiki entry for GABPA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GABPA Gene

Genomics for GABPA Gene

Genomic Location for GABPA Gene

Start:
25,734,570 bp from pter
End:
25,772,460 bp from pter
Size:
37,891 bases
Orientation:
Plus strand

Genomic View for GABPA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GABPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GABPA Gene

Regulatory Elements for GABPA Gene

Transcription factor binding sites by QIAGEN in the GABPA gene promoter:

Proteins for GABPA Gene

  • Protein details for GABPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06546-GABPA_HUMAN
    Recommended name:
    GA-binding protein alpha chain
    Protein Accession:
    Q06546
    Secondary Accessions:
    • Q12939

    Protein attributes for GABPA Gene

    Size:
    454 amino acids
    Molecular mass:
    51295 Da
    Quaternary structure:
    • Heterotetramer of two alpha and two beta subunits

neXtProt entry for GABPA Gene

Proteomics data for GABPA Gene at MOPED

Post-translational modifications for GABPA Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys359

Other Protein References for GABPA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GABPA Gene

Domains for GABPA Gene

UniProtKB/Swiss-Prot:

GABPA_HUMAN
Domain:
  • Contains 1 ETS DNA-binding domain.:
    • Q06546
  • Contains 1 PNT (pointed) domain.:
    • Q06546
Family:
  • Belongs to the ETS family.:
    • Q06546
genes like me logo Genes that share domains with GABPA: view

No data available for Gene Families for GABPA Gene

Function for GABPA Gene

Molecular function for GABPA Gene

GENATLAS Biochemistry: GA binding protein,alpha subunit with an ETS related domain,component of the nuclear respiratory factor 2,ubiquitously expressed,interacting with the four ankyrin-type repeats to form a high affinity DNA-binding complex recognizing an important site for herpes simplex virus type I activation,putatively involved in the activation of nuclear genes specifying mitochondrial function
UniProtKB/Swiss-Prot Function: Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene

Gene Ontology (GO) - Molecular Function for GABPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 12750007
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 12750007
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 22306510
GO:0003677 DNA binding TAS 8441384
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with GABPA: view
genes like me logo Genes that share phenotypes with GABPA: view

Animal Models for GABPA Gene

MGI Knock Outs for GABPA:

miRNA for GABPA Gene

miRTarBase miRNAs that target GABPA
Targeting motifs for GABPA Gene
HOMER Transcription Factor Regulatory Elements motif GABPA
  • Consensus sequence: AACCGGAAGT Submotif: canonical Cell Type: Jurkat GeoId: GSE17954

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for GABPA Gene

Localization for GABPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for GABPA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GABPA Gene COMPARTMENTS Subcellular localization image for GABPA gene
Compartment Confidence
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GABPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 22306510
GO:0005634 nucleus IDA 9857059
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with GABPA: view

Pathways for GABPA Gene

genes like me logo Genes that share pathways with GABPA: view

Pathways by source for GABPA Gene

1 Qiagen pathway for GABPA Gene

Gene Ontology (GO) - Biological Process for GABPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001701 in utero embryonic development IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0006366 transcription from RNA polymerase II promoter TAS 8441384
genes like me logo Genes that share ontologies with GABPA: view

Compounds for GABPA Gene

(9) Novoseek inferred chemical compound relationships for GABPA Gene

Compound -log(P) Hits PubMed IDs
tbhq 74.1 9
diethylmaleate 57.5 3
curcumin 37.6 3
arsenite 35.5 3
oxygen 23.4 5
genes like me logo Genes that share compounds with GABPA: view

Transcripts for GABPA Gene

Unigene Clusters for GABPA Gene

GA binding protein transcription factor, alpha subunit 60kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GABPA Gene

No ASD Table

Relevant External Links for GABPA Gene

GeneLoc Exon Structure for
GABPA
ECgene alternative splicing isoforms for
GABPA

Expression for GABPA Gene

mRNA expression in normal human tissues for GABPA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GABPA Gene

SOURCE GeneReport for Unigene cluster for GABPA Gene Hs.473470

genes like me logo Genes that share expressions with GABPA: view

Orthologs for GABPA Gene

This gene was present in the common ancestor of animals.

Orthologs for GABPA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GABPA 36
  • 99.93 (n)
  • 100 (a)
GABPA 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GABPA 36
  • 93.25 (n)
  • 98.68 (a)
GABPA 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GABPA 36
  • 93.54 (n)
  • 99.12 (a)
GABPA 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gabpa 36
  • 89.7 (n)
  • 96.25 (a)
Gabpa 16
Gabpa 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GABPA 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GABPA 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gabpa 36
  • 90.9 (n)
  • 98.24 (a)
chicken
(Gallus gallus)
Aves GABPA 36
  • 82.12 (n)
  • 93.38 (a)
GABPA 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GABPA 37
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.34617 36
tropical clawed frog
(Silurana tropicalis)
Amphibia gabpa 36
  • 78.24 (n)
  • 88.05 (a)
Str.8903 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13854 36
zebrafish
(Danio rerio)
Actinopterygii e4tf 36
gabpa 36
  • 70.08 (n)
  • 76.99 (a)
gabpa 37
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004337 36
  • 53.05 (n)
  • 51.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ets97D 36
  • 48.23 (n)
  • 41.92 (a)
Ets97D 37
  • 36 (a)
OneToOne
Ets97D 38
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 45 (a)
OneToOne
Species with no ortholog for GABPA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GABPA Gene

ENSEMBL:
Gene Tree for GABPA (if available)
TreeFam:
Gene Tree for GABPA (if available)

Paralogs for GABPA Gene

Paralogs for GABPA Gene

Selected SIMAP similar genes for GABPA Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for GABPA Gene

genes like me logo Genes that share paralogs with GABPA: view

Variants for GABPA Gene

Sequence variations from dbSNP and Humsavar for GABPA Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs2694 -- 25,769,427(+) TGTGT(A/G)TGTTA utr-variant-3-prime
rs764651 -- 25,747,334(-) ATAAA(A/G)AAAGC intron-variant
rs764652 -- 25,747,094(-) tttaa(A/C)ctctt intron-variant
rs928265 -- 25,749,481(+) AAGCT(A/G)CCATG intron-variant
rs1015004 -- 25,756,782(+) TGTTC(A/G)TGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GABPA Gene

Variant ID Type Subtype PubMed ID
nsv913653 CNV Loss 21882294
nsv913654 CNV Loss 21882294

Relevant External Links for GABPA Gene

HapMap Linkage Disequilibrium report
GABPA

Disorders for GABPA Gene

(1) MalaCards Diseases for GABPA Gene

Search for GABPA Gene in MalaCards »

(1) Novoseek inferred disease relationships for GABPA Gene

Disease -log(P) Hits PubMed IDs
neurodegenerative diseases 28.9 2

Relevant External Links for GABPA

Genetic Association Database (GAD)
GABPA
Human Genome Epidemiology (HuGE) Navigator
GABPA
genes like me logo Genes that share disorders with GABPA: view

No data available for UniProtKB/Swiss-Prot for GABPA Gene

Publications for GABPA Gene

  1. Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain. (PMID: 7799916) Gugneja S. … Scarpulla R.C. (Mol. Cell. Biol. 1995) 3 4 23
  2. cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs. (PMID: 8441384) Watanabe H. … Handa H. (Mol. Cell. Biol. 1993) 2 3 4
  3. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PMID: 18660489) Lu Y. … Boer J.M. (J. Lipid Res. 2008) 3 49
  4. Nuclear respiratory factor 2 induces the expression of many but not all human proteins acting in mitochondrial DNA transcription and replication. (PMID: 19951946) Bruni F. … Roberti M. (J. Biol. Chem. 2010) 3 23
  5. Activation of synoviolin promoter in rheumatoid synovial cells by a novel transcription complex of interleukin enhancer binding factor 3 and GA binding protein alpha. (PMID: 19116932) Izumi T. … Nakajima T. (Arthritis Rheum. 2009) 3 23

Products for GABPA Gene

Sources for GABPA Gene

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