Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GABPA Gene

protein-coding GIFtS: 56
GCID: GC21P027106

GA binding protein transcription factor, alpha subunit 6...

(Previous names: GA-binding protein transcription factor, alpha subunit...)

Explore 27 diseases affiliated with
GABPA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, and/or ¹¹Nature:405,311-319 and CroW21)
About This Section

Aliases
GA Binding Protein Transcription Factor, Alpha Subunit 60kDa¹ ²		Transcription Factor E4TF1-60² ³
E4TF1A¹ ² ³ ⁵		GABP Subunit Alpha² ³
E4TF1-60¹ ²		GA-Binding Protein Transcription Factor, Alpha Subunit (60kD)¹
NFT2¹ ²		RCH04A07²
NRF2¹ ²		GA Binding Protein Transcription Factor Alpha Subunit 60kDa²
NRF2A¹ ²		GA-Binding Protein Alpha Chain²
Human Nuclear Respiratory Factor-2 Subunit Alpha² 11		Nuclear Respiratory Factor 2 Alpha Subunit²
Nuclear Respiratory Factor 2 Subunit Alpha² ³

External Ids:	HGNC: 4071¹	Entrez Gene: 2551²	Ensembl: ENSG00000154727⁷	OMIM: 600609⁵	UniProtKB: Q06546³

Export aliases for GABPA gene to outside databases

Previous GC identifers: GC21P023686 GC21P026023 GC21P026029 GC21P026028 GC07P062691

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GABPA:

This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding

subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is

likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This

subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of

the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other

polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same

protein have been found for this gene. (provided by RefSeq, Oct 2010)

UniProtKB/Swiss-Prot: GABPA_HUMAN, Q06546

Function: Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the

expression of the Adenovirus E4 gene

Gene Wiki entry for GABPA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

RefSeq DNA sequence:

NC_000021.8 NC_018932.1 NT_011512.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GABPA gene promoter:
TBP
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GABPA promoter sequence

Search SABiosciences Chromatin IP Primers for GABPA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GABPA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.3 Ensembl cytogenetic band: 21q21.3 HGNC cytogenetic band: 21q21-q22.1
Nature(405: 311-319) cytogenetic band: 21q21.3

GABPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GABPA gene location

GeneLoc information about chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21P027106:	GeneLoc	Nature:405,311-319
Start:	27,106,881 bp from pter	12,685,464 bp from centromere
End:	27,144,771 bp from pter	12,719,695 bp from centromere
Size:	37,891 bases	34,232 bases
Orientation:	plus strand	plus strand

1 alternative location:

Chr7+,CRA_TCAG 62,691,045-62,695,882

Whole chromosome sequencing:
cDNA sequence:	U13044 D13318
genomic clones:	pT172

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GABPA_HUMAN, Q06546 (See protein sequence)

Recommended Name: GA-binding protein alpha chain

Size: 454 amino acids; 51295 Da

Subunit: Heterotetramer of two alpha and two beta subunits

Subcellular location: Nucleus

Secondary accessions: Q12939

Explore the universe of human proteins at neXtProt for GABPA: NX_Q06546

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q06546

GABPA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001184226.1 NP_002031.2

ENSEMBL proteins:

ENSP00000346886 ENSP00000382948

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: GABPA OriGene Protein Over-expression Lysate: GABPA OriGene Custom Protein Services for GABPA
	GenScript Custom Purified and Recombinant Proteins Services for GABPA
	Novus Biologicals GABPA Proteins Novus Biologicals GABPA Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000790	nuclear chromatin	IDA	--
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--

GABPA for ontologies About GeneDecksing

GABPA Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for GABPA
	GenScript Custom Superior Antibodies Services for GABPA
	Novus Biologicals GABPA Antibodies
	Search for Antibodies for GABPA at Abcam
	Browse Antibodies at Uscn
	ThermoFisher Antibody for GABPA

Assay Products for GABPA:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for GABPA
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GABPA for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR000418 Ets_dom

IPR024668 GABP_asu_N

IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

IPR003118 Pointed_dom

IPR013761 SAM/pointed

Graphical View of Domain Structure for InterPro Entry Q06546

ProtoNet protein and cluster: Q06546

1 Blocks protein family: IPB003118 Sterile alpha motif (SAM)/Pointed domain

UniProtKB/Swiss-Prot: GABPA_HUMAN, Q06546

Similarity: Belongs to the ETS family

Similarity: Contains 1 ETS DNA-binding domain

Similarity: Contains 1 PNT (pointed) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GABPA_HUMAN, Q06546

Function: Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the

expression of the Adenovirus E4 gene

Genatlas biochemistry entry for GABPA:

GA binding protein,alpha subunit with an ETS related domain,component of the nuclear respiratory factor 2,ubiquitously

expressed,interacting with the four ankyrin-type repeats to form a high affinity DNA-binding complex recognizing an

important site for herpes simplex virus type I activation,putatively involved in the activation of nuclear genes

specifying mitochondrial function

miRNA Products:		OriGene 3'-UTR Clone: GABPA Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GABPA
		8/123 QIAGEN miScript miRNA Assays for microRNAs that regulate GABPA (see all 123):
		hsa-miR-411* hsa-miR-579 hsa-miR-548j hsa-miR-193a-3p hsa-miR-607 hsa-miR-146a hsa-miR-15a hsa-miR-374a

		SwitchGear 3'UTR luciferase reporter plasmid: GABPA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GABPA (see all 7) OriGene shRNA RFP: GABPA OriGene siRNA: GABPA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GABPA

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for GABPA

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GABPA (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GABPA OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): GABPA (NM_002040)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GABPA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GABPA

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GABPA
		Search LifeMap BioReagents cell lines for GABPA

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABPA

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	IDA	--
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	IDA	--
GO:0003677	DNA binding	TAS	8441384
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS	8441384
GO:0003713	transcription coactivator activity	TAS	8441384

GABPA for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for GABPA:

Decreased viability with pacli

Animal Models:
Mouse knock-outs for GABPA: Gabpa^tm1.1Sjb Gabpa^tm1Rist
11 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Gabpa):

cellular	embryogenesis	growth/size	hematopoietic system	homeostasis/metabolism
immune system	mortality/aging	muscle	nervous system	no phenotypic analysis
normal

GABPA for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Agrin Interactions at Neuromuscular Junction

Agrin Interactions at Neuromuscular Junction

1.00

Calcium Regulation in the Cardiac Cell

Myometrial Relaxation and Contraction Pathways

0.43

The fatty acid cycling model

Energy Metabolism

0.04

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for GABPA

Agrin Interactions at Neuromuscular Junction

2 BioSystems Pathways for GABPA

	Myometrial Relaxation and Contraction Pathways
	Energy Metabolism

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GABPA

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/21 Interacting proteins for GABPA (Q06546^{1, 2, 3} ENSP00000346886⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HCFC1	P51610¹^,³, ENSP00000309555⁴	EBI-638925,EBI-2832627 I2D: score=4 STRING: ENSP00000309555
SP1	P08047²^,³, ENSP00000329357⁴	MINT-49851 MINT-49852 I2D: score=4 STRING: ENSP00000329357
SP3	Q02447²^,³, ENSP00000310301⁴	MINT-49853 MINT-49854 I2D: score=4 STRING: ENSP00000310301
GABPB1	Q06547³, ENSP00000370259⁴	I2D: score=4 STRING: ENSP00000370259
ATF1	P18846³, ENSP00000262053⁴	I2D: score=3 STRING: ENSP00000262053

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0001701	in utero embryonic development	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	--	--
GO:0006366	transcription from RNA polymerase II promoter	TAS	8441384

GABPA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GABPA for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GABPA
9 Novoseek chemical compound relationships for GABPA gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tbhq	74.1	19	15525690 (5), 19174151 (2), 15582588 (1), 15923610 (1)
diethylmaleate	57.5	7	15521073 (1), 17077087 (1), 15379550 (1)
curcumin	37.6	4	17913594 (1), 17449203 (1), 15923610 (1)
arsenite	35.5	3	15521073 (1), 18572023 (1), 12745069 (1)
oxygen	23.4	7	19679692 (2), 17077087 (1), 18717629 (1), 20030899 (1)
atp	0	3	1656236 (2), 12539966 (1)
lipid	0	2	18230803 (1)
calcium	0	2	12665481 (2)
serine	0	1	7799916 (1)

Search CenterWatch for drugs/clinical trials and news about GABPA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GABPA gene (2 alternative transcripts):

NM_001197297.1 NM_002040.3

Unigene Cluster for GABPA:

GA binding protein transcription factor, alpha subunit 60kDa

Hs.473470 [show with all ESTs]

Unigene Representative Sequence: BX647755

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000354828(uc002ylx.4) ENST00000400075(uc002yly.4) ENST00000487266

miRNA Products:		OriGene 3'-UTR Clone: GABPA Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GABPA
		8/123 QIAGEN miScript miRNA Assays for microRNAs that regulate GABPA (see all 123):
		hsa-miR-411* hsa-miR-579 hsa-miR-548j hsa-miR-193a-3p hsa-miR-607 hsa-miR-146a hsa-miR-15a hsa-miR-374a

		SwitchGear 3'UTR luciferase reporter plasmid: GABPA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GABPA (see all 7) OriGene shRNA RFP: GABPA OriGene siRNA: GABPA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GABPA

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GABPA (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GABPA OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): GABPA (NM_002040)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GABPA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GABPA

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GABPA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat GABPA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GABPA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GABPA

Additional cDNA sequence:

AK223164.1 AK313545.1 BC035031.2 BX647755.1 D13318.1 EU159453.1 JQ313900.1 U13044.1

X84366.1

12 DOTS entries:

DT.99933995 DT.99992826 DT.100727081 DT.453987 DT.121138154 DT.121138106 DT.70101580 DT.121137994

DT.121138144 DT.437389 DT.92407558 DT.121079420

24/135 AceView cDNA sequences (see all 135):

BQ023312 AA935134 BQ423139 BM974511 BX647755 AA497016 AI990899 AW105605

BU188528 NM_002040 AU107258 X84366 AU107257 AI554509 CA952631 AI378047

BM977191 AA489598 BM464174 BM477941 BQ216320 AA704298 AA946680 BI826069

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GABPA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAGTTTTT

About this image
See GABPA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GABPA

SOURCE GeneReport for Unigene cluster: Hs.473470

SABiosciences Custom PCR Arrays for GABPA

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GABPA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat GABPA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GABPA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GABPA

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABPA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for GABPA gene from 6/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	GABPA¹	GA binding protein transcription factor, alpha subunit more	82.12(n) 93.38(a)		418478 NM_001007858.1 NP_001007859.1
lizard (Anolis carolinensis)	Reptilia	GABPA⁶	--	94(a)	1 ↔ 1	3(148259826-148274981)
African clawed frog (Xenopus laevis)	Amphibia	Xl.34617²	Xenopus laevis transcribed sequence with moderate similarity more	78.03(n)		BJ095846.1
zebrafish (Danio rerio)	Actinopterygii	e4tf²	E4tf1-60 transcription factor	74.07(n)		58110 AF257741.1
fruit fly (Drosophila melanogaster)	Insecta	Ets97D^{1 , 3}	DNA binding³ Ets at 97D¹	38(a)³ 48.48(n)¹ 42.17(a)¹		3 97D7³ 43236¹ NM_079799.3¹ NP_524523.2¹
worm (Caenorhabditis elegans)	Secernentea	ets-7⁶ ets-8⁶ (see all 3)	Protein ETS-8 (see all 3)	16(a) 15(a) (see all 3)	possible ortholog possible ortholog (see all 3)	V(7557738-7558764) IV(1159637-1161545)

ENSEMBL Gene Tree for GABPA (if available)
TreeFam Gene Tree for GABPA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GABPA gene

ELK4² ETV1² ETV3² ERF² ETV5² ETV3L² ETS1² ETS2²

ERG² ELK1² FEV² ETV4² ETV2² FLI1² ELK3²

3 SIMAP similar genes for GABPA using alignment to 3 protein entries: GABPA_HUMAN (see all proteins):

GABPAP FEV ELK3

GABPA for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for GABPA
PGOHUM00000233346

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 21 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11384760^1,2	C,	--	27114546(+)	`AATCC-/AAGGAG`	2	--	int¹		0	--	--	--	--
rs5843170^1,2	C,	--	27116381(+)	`TACCAT/-GGCTA`	2	--	int¹		1		NA	2
rs36059786^1,2	C,	--	27116999(+)	`ATACA-/TTTTTT`	1	--	int¹		2		NA	4
rs11373367^1,2	C,	--	27123583(+)	`TAATA-/GGTTTA`	2	--	int¹		0	--	--	--	--
rs5843171^1,2	C	--	27129757(+)	`TTGTA-/TTTC TTAGT`	1	--	int¹		0	--	--	--	--
rs144338599^1,2	C,	--	27129757(+)	`TTGTA-/TTTC TTAGT`	1	--	int¹		0	--	--	--	--
rs35779696^1,2	C,F	--	27129759(+)	`GTATTTCTT/- AGTGT`	2	--	int¹		6		NA NS	134
rs1573269^1,2	F	--	27129760(+)	`TATTTA/CTTAGT`	1	--	int¹		5		EA NA	146
rs10688128^1,2	C,	--	27136246(+)	`AAATA-/CTCTCTT`	2	--	int¹		0	--	--	--	--
rs56048433^1,2	C,F	--	27141277(+)	`CATTTATTT/- TTTCT`	2	--	int¹		6		NA NS	174

HapMap Linkage Disequilibrium report for GABPA (27106881 - 27144771 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GABPA: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GABPA

DNA2.0 Custom Variant and Variant Library Synthesis for GABPA

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GABPA for disorders           About GeneDecksing

OMIM gene information: 600609    OMIM disorders: --

20/27 diseases for GABPA (see all 27):    About MalaCards

down syndrome complex regional pain syndrome cystic fibrosis lung disease paine syndrome

friedreich ataxia cystic fibrosis neurodegenerative disease herpes simplex

intrahepatic cholangiocarcinoma ulcerative colitis fibrosis pulmonary fibrosis

rheumatoid arthritis multiple sclerosis emphysema cholangiocarcinoma

gastritis noma ataxia arthritis

1 Novoseek disease relationship for GABPA gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
neurodegenerative diseases	28.9	2	18824091 (1), 18717629 (1)

Genetic Association Database (GAD): GABPA
Human Genome Epidemiology (HuGE) Navigator: GABPA (3 documents)

Export disorders for GABPA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for GABPA gene, integrated from 9 sources (see all 142):
(articles sorted by number of sources associating them with GABPA)

Utopia: connect your pdf to the dynamic
world of online information

cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs. (PubMed id 8441384)^{1, 2, 3} Watanabe H.... Handa H. (1993)
Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain. (PubMed id 7799916)^{1, 2, 9} Gugneja S.... Scarpulla R.C. (1995)
Nuclear respiratory factor 2 induces the expression o f many but not all human proteins acting in mitochondrial DNA transcription and replication. (PubMed id 19951946)^{1, 9} Bruni F....Roberti M. (2010)
In vitro methylation of nuclear respiratory factor-2 binding sites suppresses the promoter activity of the human TOMM70 gene. (PubMed id 18852034)^{1, 9} Blesa J.R....Hernandez-Yago J. (2008)
Identification of polymorphisms in the promoter region of the human NRF2 gene. (PubMed id 15358217)^{4, 9} Yamamoto T....Yamamoto M. (2004)
Mapping of the human transcription factor GABPA (E4TF1-60) gene to chromosome 21. (PubMed id 7590737)^{1, 9} Chrast R....Antonarakis S.E. (1995)
Human nuclear respiratory factor 2 alpha subunit cDNA: isolation, subcloning, sequencing, and in situ hybridization of transcripts in normal and monocularly deprived macaque visual system. (PubMed id 10660899)^{1, 9} Guo A....Wong-Riley M. (2000)
Nuclear respiratory factor 2 activates transcription of human mitochondrial translation initiation factor 2 gene. (PubMed id 17161026)^{1, 9} Hayashi R....Takeuchi N. (2007)
Activation of synoviolin promoter in rheumatoid synovial cells by a novel transcription complex of interleukin enhancer binding factor 3 and GA binding protein alpha. (PubMed id 19116932)^{1, 9} Izumi T....Nakajima T. (2009)
Methylation-sensitive Regulation of TMS1/ASC by the Ets Factor, GA-binding Protein-{alpha}. (PubMed id 19324871)^{1, 9} Lucas M.E....Vertino P.M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2551	HGNC: 4071	AceView: GABPA	Ensembl:ENSG00000154727	euGenes: HUgn2551
ECgene: GABPA	H-InvDB: GABPA

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GABPA	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GABPA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for GABPA gene:
Search GeneIP for patents involving GABPA

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for GABPA
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GABPA		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GABPA
	OriGene Protein Over-expression Lysate for GABPA		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for GABPA		OriGene 3'-UTR Clone for GABPA
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GABPA		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GABPA
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for GABPA		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for GABPA		OriGene Custom Protein Services for GABPA
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GABPA
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GABPA
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GABPA
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GABPA
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GABPA
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GABPA

	GenScript Custom Purified and Recombinant Proteins Services for GABPA		GenScript cDNA clones with any tag delivered in your preferred vector for GABPA
	GenScript Custom Assay Services for GABPA		GenScript Custom Superior Antibodies Services for GABPA
	GenScript Custom overexpressing Cell Line Services for GABPA		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in GABPA promoter
	Search Chromatin IP Primers for GABPA
	RT² qPCR Primer Assay in human, mouse, rat GABPA
	GNC Network for GABPA
	SABiosciences PCR Arrays including human, mouse, rat GABPA

Search Tocris compounds for GABPA

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	GABPA antibodies
	GABPA proteins
	GABPA lysates

	Search for Antibodies for GABPA at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for GABPA
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for GABPA

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABPA

	SwitchGear 3'UTR luciferase reporter plasmids for GABPA
	SwitchGear Promoter luciferase reporter plasmids for GABPA

ThermoFisher Antibody for GABPA

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GABPA

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes GABPA gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

GABPA Gene

GA binding protein transcription factor, alpha subunit 6...

Aliases
for GABPA gene

Summaries
for GABPA gene

Genomic Views
for GABPA gene

Proteins
for GABPA gene

Protein Domains /
Families
for GABPA gene

Function
for GABPA gene

Pathways & Interactions
for GABPA gene

Drugs & Compounds
for GABPA gene

Transcripts
for GABPA gene

Expression
for GABPA gene

Orthologs
for GABPA gene

Paralogs
for GABPA gene

Genomic Variants
for GABPA gene

Disorders / Diseases
for GABPA gene

Publications
for GABPA gene

External Searches for GABPA gene

Genome Databases showing GABPA gene

Other Databases showing GABPA gene

Specialized Databases showing GABPA gene

Intellectual Property
for GABPA gene

Products
for GABPA gene

View Random Gene

Advanced Search

Export list of displayed genes

GABPA Gene

GA binding protein transcription factor, alpha subunit 6...

Aliasesfor GABPA gene

Summariesfor GABPA gene

Genomic Viewsfor GABPA gene

Proteinsfor GABPA gene

Protein Domains /Familiesfor GABPA gene

Functionfor GABPA gene

Pathways & Interactionsfor GABPA gene

Drugs & Compoundsfor GABPA gene

Transcriptsfor GABPA gene

Expression for GABPA gene

Orthologsfor GABPA gene

Paralogsfor GABPA gene

Genomic Variantsfor GABPA gene

Disorders / Diseasesfor GABPA gene

Publicationsfor GABPA gene

External Searches for GABPA gene

Genome Databases showing GABPA gene

Other Databases showing GABPA gene

Specialized Databases showing GABPA gene

Intellectual Propertyfor GABPA gene

Productsfor GABPA gene

View Random Gene

Aliases
for GABPA gene

Summaries
for GABPA gene

Genomic Views
for GABPA gene

Proteins
for GABPA gene

Protein Domains /
Families
for GABPA gene

Function
for GABPA gene

Pathways & Interactions
for GABPA gene

Drugs & Compounds
for GABPA gene

Transcripts
for GABPA gene

Expression
for GABPA gene

Orthologs
for GABPA gene

Paralogs
for GABPA gene

Genomic Variants
for GABPA gene

Disorders / Diseases
for GABPA gene

Publications
for GABPA gene

Intellectual Property
for GABPA gene

Products
for GABPA gene