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Aliases &
Descriptions
for GABBR2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| FLJ36928 2 | | GABA-B-R2 3 | | GABABR2 1, 2, 3 | | GPR51 2, 3, 5 | | GPRC3B 1, 2, 3 | | Gb2 3 | | HG20 1, 2, 3 | | HRIHFB2099 2 | | OTTHUMP00000021776 2 | | OTTHUMP00000063797 2 |
| | | Descriptions |
|---|
| G protein-coupled receptor 51 1, 2 | | G-protein coupled receptor 51 3 | | GABA-B receptor 2 3 | | gamma-aminobutyric acid (GABA) B receptor, 2 2 | | gamma-aminobutyric acid B receptor, 2 1 |
|
| |
Search outside databases for aliases for GABBR2 gene |
Summaries
for GABBR2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for GABBR2:
B-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity
through G protein-coupled second-messenger systems, which regulate the release of
neurotransmitters and the activity of ion channels and adenylyl cyclase. See GABBR1 (MIM 603540)
for additional background information on GABA-B receptors.[supplied by OMIM]
UniProtKB/Swiss-Prot: GABR2_HUMAN, O75899Function: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit
adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates
voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a
critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R
inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels,
whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly
rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials.
Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow
wave sleep, muscle relaxation and antinociceptionGene Wiki entry for GABBR2 |
Genomic Location
for GABBR2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the GABBR2 gene 
Entrez Gene cytogenetic band: 9q22.1-q22.3 Ensembl cytogenetic band: 9q22.33 HGNC cytogenetic band: 9q22.1-q22.3GABBR2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M100090:
(about GC identifiers)
Start:
|
100,090,187 bp from pter |
End:
|
100,511,300 bp from pter |
Size:
|
421,114 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000009.10 NT_008470.18
| Proteins
for GABBR2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: GABR2_HUMAN, O75899 (See
protein sequence)Recommended Name: Gamma-aminobutyric acid type B receptor subunit 2 precursor Size: 941 amino acids; 105821 Da
Subunit: Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and
homodimeric assembly does not seem to happen. Interacts with ATF4 via its C-terminal region
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse,
postsynaptic cell membrane; Multi-pass membrane protein. Note=Moreover coexpression of GABA-B-R1
and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma
membrane
Secondary accessions: O75974 O75975 Q5VXZ2 Q8WX04 Q9P1R2 Q9UNR1 Q9UNS9Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005449.5
ENSEMBL proteins: ENSP00000259455
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7
): About this table
Antibodies for GABBR2:
Assays for GABBR2: | Protein
Domains/
Families
for GABBR2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O75899
ProtoNet protein and cluster: O75899 3 Blocks protein families: IPB001828 Extracellular ligand-binding receptor IPB002455 Metabotropic gamma-aminobutyric acid type B receptor signature IPB002457 Metabotropic gamma-aminobutyric acid type B2 receptor signature
UniProtKB/Swiss-Prot: GABR2_HUMAN, O75899Domain: Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric
interaction with GABA-B receptor 1Similarity: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily | Gene Function
for GABBR2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005458
 Applied Biosystems Silencer® siRNAs for GABBR2
 Sigma-Aldrich siRNA and siRNA Panels for GABBR2
Sigma-Aldrich shRNA Panels and shRNA for GABBR2
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_005458
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005458
untagged cDNA clone in CMV expression vector: NM_005458
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_005458
UniProtKB/Swiss-Prot: GABR2_HUMAN, O75899Function: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit
adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates
voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a
critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R
inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels,
whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly
rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials.
Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow
wave sleep, muscle relaxation and antinociception6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Gabbr2):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions
for GABBR2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Sigma-Aldrich "Your Favorite Gene" Pathway for GABBR2 (Your Favorite Gene powered by Ingenuity)
5/11 Interacting proteins for GABBR2 (O758992 ENSP000002594553) via UniProtKB, MINT, and/or STRING (see all 11
)About this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds
for GABBR2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for GABBR2 |
 Compounds for GABBR2 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| 2-Hydroxysaclofen | Selective GABAB antagonist, more potent than Cat. No. 0246 | [117354-64-0] | | CGP 55845 | Potent, selective GABAB antagonist | [149184-22-5] | | SCH 50911 | Selective, competitive, orally active GABAB antagonist | [160415-07-6] | | CGP 52432 | Potent, selective GABAB antagonist | [139667-74-6] |
About this table
1  Novoseek chemical compound relationship for GABBR2 gene
About this table
|
Transcripts
for GABBR2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005458
Sigma-Aldrich siRNA and siRNA Panels for GABBR2
Sigma-Aldrich shRNA Panels and shRNA for GABBR2
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_005458 REFSEQ mRNAs for GABBR2 gene: NM_005458.6
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005458
OriGene GFP tagged cDNA clone in CMV expression vector: NM_005458
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005458
untagged cDNA clone in CMV expression vector: NM_005458
Additional cDNA sequence: AB015334.1 AF056085.1 AF069755.1 AF074483.1 AF099033.1 AJ012188.1 AK308139.1 BC031317.2 BC035071.2 BC055425.1 8 DOTS entries: DT.406980 DT.212066 DT.91819307 DT.95369466 DT.100757122 DT.121166229 DT.40202599 DT.425442 24/88 AceView cDNA sequences (see all 88
):AW138313 BM666403 BX420187 BM722398 F10549 AV726980 AJ012188 AF099033 BM663744 AA613872 AA351057 AF056085 AI341249 BC035071 BF791371 BM678928 BQ340856 BP362109 BM724511 BU736718 AV728164 AA325383 AI500214 AA775405
 highest scoring ESTs for GABBR2:AF056085 AF069755 AF074483 AF099033 AJ012188 AA011645 AA063059 AA324303 AA351057 AA452928 Unigene Cluster for GABBR2: Gamma-aminobutyric acid (GABA) B receptor, 2 Hs.198612 [show with all ESTs]Unigene Representative Sequence: AF056085
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000259455
|
Expression
for GABBR2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| GABBR2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for GABBR2
1 / 2 / 3 9 probe-sets matching GABBR2 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GTATCGATTT
SOURCE GeneReport for Unigene cluster: Hs.198612
UniProtKB/Swiss-Prot: GABR2_HUMAN, O75899Tissue specificity: Highly expressed in brain, especially in cerebral cortex, thalamus,
hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by
corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart,
testis and skeletal muscle |
Orthologs
for GABBR2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GABBR2 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for GABBR2
ENSEMBL Gene Tree for GABBR2 | Paralogs
for GABBR2(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for GABBR2 gene
- ENSG000002046812 GPR1562
|
SNPs/Variants
for GABBR2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for GABBR2 (up to first 250kb)
|
Disorders & Mutations
for GABBR2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 607340 disorders: 188890 188890 2 Novoseek disease relationships for GABBR2 gene
About this table
Human Genome Epidemiology Navigator: GABBR2 (6 documents)
|
Medical News
for GABBR2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for GABBR2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/45 PubMed articles for GABBR2 gene (see all 45
):- Cloning of a novel G-protein-coupled receptor GPR 51 resembling GABAB receptors expressed predominantly in nervous tissues and mapped proximal to the hereditary sensory neuropathy type 1 locus on chromosome 9. (PubMed id 10087195)2, 3, 4 Ng G.Y.K.... Liu Q. (1999)
- Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1. (PubMed id 10328880)1, 3, 4 Martin S.C.... Farb D.H. (1999)
- Distribution of the GABA(B) receptor subunit gb2 in rat CNS. (PubMed id 10727622)1, 3, 4 Clark J.A.... Bonner T.I. (2000)
- Phosphoproteomic analysis of synaptosomes from human cerebral cortex. (PubMed id 15822905)3, 4 DeGiorgis J.A.... Dosemeci A. (2005)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)3, 4 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor. (PubMed id 10773016)3, 4 Sullivan R.... Ng G.Y.K. (2000)
- Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity. (PubMed id 10075644)3, 4 Ng G.Y.K.... O'Neill G.P. (1999)
- Heterodimerization is required for the formation of a functional GABA(B) receptor. (PubMed id 9872316)3, 4 White J.H.... Marshall F.H. (1998)
- Comparative cellular distribution of GABAA and GABAB receptors in the human basal ganglia: immunohistochemical colocalization of the alpha 1 subunit of the GABAA receptor, and the GABABR1 and GABABR2 receptor subunits. (PubMed id 14961561)1, 3 Waldvogel H.J....Faull R.L. (2004)
|
Search for GABBR2
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GABBR2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing GABBR2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GABBR2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for GABBR2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for GABBR2:
 | |
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