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Aliases for GABARAPL2 Gene

Aliases for GABARAPL2 Gene

  • GABA Type A Receptor Associated Protein Like 2 2 3 5
  • Golgi-Associated ATPase Enhancer Of 16 KDa 3 4
  • GABA(A) Receptor-Associated Protein-Like 2 3 4
  • General Protein Transport Factor P16 3 4
  • Ganglioside Expression Factor 2 3 4
  • GATE-16 3 4
  • GEF-2 3 4
  • GEF2 3 4
  • Gamma-Aminobutyric Acid Receptor-Associated Protein-Like 2 3
  • GABA(A) Receptor-Associated Protein Like 2 2
  • MAP1 Light Chain 3 Related Protein 3
  • MAP1 Light Chain 3-Related Protein 4
  • GATE16 3
  • ATG8C 3
  • FLC3A 4
  • ATG8 3

External Ids for GABARAPL2 Gene

Previous GeneCards Identifiers for GABARAPL2 Gene

  • GC16P066530
  • GC16P076560
  • GC16P075339
  • GC16P075380
  • GC16P075381
  • GC16P074157
  • GC16P075600
  • GC16P061353

Summaries for GABARAPL2 Gene

GeneCards Summary for GABARAPL2 Gene

GABARAPL2 (GABA Type A Receptor Associated Protein Like 2) is a Protein Coding gene. Diseases associated with GABARAPL2 include Amyotrophic Lateral Sclerosis Type 14. Among its related pathways are Vesicle-mediated transport and Circadian entrainment. GO annotations related to this gene include microtubule binding and SNARE binding. An important paralog of this gene is GABARAPL1.

UniProtKB/Swiss-Prot for GABARAPL2 Gene

  • Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Gene Wiki entry for GABARAPL2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GABARAPL2 Gene

Genomics for GABARAPL2 Gene

Regulatory Elements for GABARAPL2 Gene

Enhancers for GABARAPL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F075593 1.5 FANTOM5 Ensembl ENCODE 11.5 +27.9 27945 1.8 ATF1 PKNOX1 GATA2 FOS SP5 CREB3 MBD2 SMARCA4 ETV4 KDM1A GABARAPL2 TMEM231 ADAT1 PIR60653 GC16P075575
GH16F075589 1.4 Ensembl ENCODE 11.6 +24.4 24387 3.3 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 TMEM231 GABARAPL2 ENSG00000261783 GLG1 ADAT1 PIR60653 GC16P075575
GH16F075619 1.1 ENCODE 11.4 +55.3 55338 4.9 PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ADAT1 TMEM231 GABARAPL2 ENSG00000261783 CHST5 ENSG00000259992
GH16F075516 1.1 ENCODE 11.2 -49.3 -49339 2.0 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ADAT1 TMEM231 CHST6 GABARAPL2 GLG1 LOC100420067 CHST5
GH16F075461 1.1 ENCODE 10.7 -102.7 -102731 3.5 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ENSG00000261783 GABARAPL2 CFDP1 BCAR1 ENSG00000261476 ENSG00000261717
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GABARAPL2 on UCSC Golden Path with GeneCards custom track

Promoters for GABARAPL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000510201 249 2001 HDGF ATF1 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 GLIS2

Genomic Location for GABARAPL2 Gene

Chromosome:
16
Start:
75,566,351 bp from pter
End:
75,577,881 bp from pter
Size:
11,531 bases
Orientation:
Plus strand

Genomic View for GABARAPL2 Gene

Genes around GABARAPL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GABARAPL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GABARAPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GABARAPL2 Gene

Proteins for GABARAPL2 Gene

  • Protein details for GABARAPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60520-GBRL2_HUMAN
    Recommended name:
    Gamma-aminobutyric acid receptor-associated protein-like 2
    Protein Accession:
    P60520
    Secondary Accessions:
    • O08765
    • Q6FG91
    • Q9DCP8
    • Q9UQF7

    Protein attributes for GABARAPL2 Gene

    Size:
    117 amino acids
    Molecular mass:
    13667 Da
    Quaternary structure:
    • Monomer. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin (By similarity). Interacts with ATG3, ATG7, ATG13 and ULK1. Interacts with TP53INP1 and TP53INP2. Interacts with TBC1D25. Directly interacts with SQSTM1 and BNIP3. Interacts with TECPR2 and PCM1. Interacts with TBC1D5 (PubMed:22354992). Interacts with TRIM5 (PubMed:25127057). Interacts with MEFV and TRIM21 (PubMed:26347139).

    Three dimensional structures from OCA and Proteopedia for GABARAPL2 Gene

neXtProt entry for GABARAPL2 Gene

Post-translational modifications for GABARAPL2 Gene

  • The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.
  • The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL2-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL2-II. ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes.
  • Ubiquitination at Lys 24
  • Modification sites at PhosphoSitePlus

Other Protein References for GABARAPL2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GABARAPL2 (GABARAPL2)
  • Cloud-Clone Corp. Antibodies for GABARAPL2

No data available for DME Specific Peptides for GABARAPL2 Gene

Domains & Families for GABARAPL2 Gene

Gene Families for GABARAPL2 Gene

Protein Domains for GABARAPL2 Gene

Graphical View of Domain Structure for InterPro Entry

P60520

UniProtKB/Swiss-Prot:

GBRL2_HUMAN :
  • Belongs to the ATG8 family.
Family:
  • Belongs to the ATG8 family.
genes like me logo Genes that share domains with GABARAPL2: view

Function for GABARAPL2 Gene

Molecular function for GABARAPL2 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Gene Ontology (GO) - Molecular Function for GABARAPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding ISS 10747018
GO:0005515 protein binding IPI 11096062
GO:0008017 microtubule binding NAS 11414770
GO:0031625 ubiquitin protein ligase binding IPI 25127057
GO:0048487 beta-tubulin binding ISS --
genes like me logo Genes that share ontologies with GABARAPL2: view
genes like me logo Genes that share phenotypes with GABARAPL2: view

Animal Models for GABARAPL2 Gene

MGI Knock Outs for GABARAPL2:

Animal Model Products

miRNA for GABARAPL2 Gene

miRTarBase miRNAs that target GABARAPL2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GABARAPL2 Gene

Localization for GABARAPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GABARAPL2 Gene

Golgi apparatus. Cytoplasmic vesicle, autophagosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GABARAPL2 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
lysosome 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GABARAPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane ISS,IDA 10747018
GO:0000421 autophagosome membrane TAS --
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm IDA 21669198
GO:0005776 autophagosome IEA,IDA 19056683
genes like me logo Genes that share ontologies with GABARAPL2: view

Pathways & Interactions for GABARAPL2 Gene

genes like me logo Genes that share pathways with GABARAPL2: view

Pathways by source for GABARAPL2 Gene

1 GeneTex pathway for GABARAPL2 Gene
1 BioSystems pathway for GABARAPL2 Gene
1 R&D Systems pathway for GABARAPL2 Gene

SIGNOR curated interactions for GABARAPL2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for GABARAPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA --
GO:0000422 mitophagy IBA --
GO:0006810 transport IEA --
GO:0006891 intra-Golgi vesicle-mediated transport ISS 10747018
GO:0006914 autophagy IEA,NAS 12507496
genes like me logo Genes that share ontologies with GABARAPL2: view

Drugs & Compounds for GABARAPL2 Gene

(1) Drugs for GABARAPL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
gamma-Aminobutyric Acid Pharma 230
genes like me logo Genes that share compounds with GABARAPL2: view

Transcripts for GABARAPL2 Gene

Unigene Clusters for GABARAPL2 Gene

GABA(A) receptor-associated protein-like 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GABARAPL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for GABARAPL2 Gene

GeneLoc Exon Structure for
GABARAPL2
ECgene alternative splicing isoforms for
GABARAPL2

Expression for GABARAPL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GABARAPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GABARAPL2 Gene

This gene is overexpressed in Brain (18.7), Fetal Brain (13.0), and Bone (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GABARAPL2 Gene



Protein tissue co-expression partners for GABARAPL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GABARAPL2 Gene:

GABARAPL2

SOURCE GeneReport for Unigene cluster for GABARAPL2 Gene:

Hs.461379

mRNA Expression by UniProt/SwissProt for GABARAPL2 Gene:

P60520-GBRL2_HUMAN
Tissue specificity: Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine.
genes like me logo Genes that share expression patterns with GABARAPL2: view

Primer Products

No data available for mRNA differential expression in normal tissues for GABARAPL2 Gene

Orthologs for GABARAPL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GABARAPL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GABARAPL2 34 35
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia GABARAPL2 34 35
  • 96.3 (n)
cow
(Bos Taurus)
Mammalia GABARAPL2 34 35
  • 95.44 (n)
rat
(Rattus norvegicus)
Mammalia Gabarapl2 34
  • 94.3 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GABARAPL2 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gabarapl2 34 16 35
  • 92.88 (n)
oppossum
(Monodelphis domestica)
Mammalia GABARAPL2 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves GABARAPL2 34 35
  • 85.19 (n)
lizard
(Anolis carolinensis)
Reptilia GABARAPL2 35
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gabarapl2 34
  • 84.2 (n)
zebrafish
(Danio rerio)
Actinopterygii gabarapl2 34 35
  • 79.77 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG8 35 37
  • 56 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ATG8B 34
  • 61.74 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5259 34
Species where no ortholog for GABARAPL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GABARAPL2 Gene

ENSEMBL:
Gene Tree for GABARAPL2 (if available)
TreeFam:
Gene Tree for GABARAPL2 (if available)

Paralogs for GABARAPL2 Gene

Paralogs for GABARAPL2 Gene

(9) SIMAP similar genes for GABARAPL2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for GABARAPL2 Gene

genes like me logo Genes that share paralogs with GABARAPL2: view

Variants for GABARAPL2 Gene

Sequence variations from dbSNP and Humsavar for GABARAPL2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1043543 -- 75,566,479(+) TCCCG(C/T)CGCCG utr-variant-5-prime
rs111253869 -- 75,567,836(+) AAAGC(A/T)CTTAC intron-variant
rs11149841 -- 75,568,899(+) TGGAT(G/T)GGCTC intron-variant
rs111613175 -- 75,571,958(+) CAGGC(A/G)TGAGC intron-variant
rs112051126 -- 75,573,680(+) ATGTT(C/G)CGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GABARAPL2 Gene

Variant ID Type Subtype PubMed ID
nsv572979 CNV gain 21841781
nsv525955 CNV loss 19592680
nsv457521 CNV gain 19166990
nsv1065995 CNV loss 25217958
nsv1063718 CNV gain 25217958

Variation tolerance for GABARAPL2 Gene

Residual Variation Intolerance Score: 57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GABARAPL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GABARAPL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GABARAPL2 Gene

Disorders for GABARAPL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GABARAPL2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis type 14
  • als14
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GABARAPL2

Genetic Association Database (GAD)
GABARAPL2
Human Genome Epidemiology (HuGE) Navigator
GABARAPL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GABARAPL2
genes like me logo Genes that share disorders with GABARAPL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GABARAPL2 Gene

Publications for GABARAPL2 Gene

  1. Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein. (PMID: 11414770) Xin Y. … Zhao S. (Genomics 2001) 2 3 4 22 64
  2. TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity. (PMID: 26347139) Kimura T. … Deretic V. (J. Cell Biol. 2015) 3 4 64
  3. TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition. (PMID: 25127057) Mandell M.A. … Deretic V. (Dev. Cell 2014) 3 4 64
  4. Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites. (PMID: 24089205) Tang Z. … Zhong Q. (Nature 2013) 3 4 64
  5. Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. (PMID: 22354992) Popovic D. … Dikic I. (Mol. Cell. Biol. 2012) 3 4 64

Products for GABARAPL2 Gene

Sources for GABARAPL2 Gene

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