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Aliases & Descriptions for GABARAPL2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| ATG8 1, 2 | | FLC3A 3 | | GATE-16 1, 2, 3 | | GATE16 1, 2 | | GEF-2 3 | | GEF2 1, 2, 3 |
| | | Descriptions |
|---|
| GABA(A) receptor-associated protein-like 2 2, 3 | | Ganglioside expression factor 2 2, 3 | | General protein transport factor p16 3 | | Golgi-associated ATPase enhancer of 16 kDa 3 | | MAP1 light chain 3 related protein 2 | | MAP1 light chain 3-related protein 3 |
|
| | Search outside databases for aliases for GABARAPL2 genePrevious GC identifers: GC16P066530 GC16P076560 GC16P075339 GC16P075380 GC16P075381 |
Summaries for GABARAPL2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: GBRL2_HUMAN, P60520Function: Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity)Gene Wiki entry for GABARAPL2 |
Genomic Location for GABARAPL2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the GABARAPL2 gene 
Entrez Gene cytogenetic band: 16q22.3-q24.1 Ensembl cytogenetic band: 16q23.1 HGNC cytogenetic band: 16q22.1GABARAPL2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P074157:
(about GC identifiers)
Start:
|
74,157,750 bp from pter |
End:
|
74,169,280 bp from pter |
Size:
|
11,531 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000016.8 NT_010498.15
| Proteins for GABARAPL2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: GBRL2_HUMAN, P60520 (See
protein sequence)Recommended Name: Gamma-aminobutyric acid receptor-associated protein-like 2 Size: 117 amino acids; 13667 Da
Subunit: Monomer. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin (By similarity). Interacts with ULK1
Subcellular location: Golgi apparatus (By similarity)
Secondary accessions: O08765 Q9DCP8 Q9UQF7Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_009216.1
ENSEMBL proteins: ENSP00000037243
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6
): About this table
Antibodies for GABARAPL2: Assays for GABARAPL2: | Protein
Domains/ Families for GABARAPL2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P60520
ProtoNet protein and cluster: P60520 1 Blocks protein family: IPB004241 Light chain 3 (LC3)
UniProtKB/Swiss-Prot: GBRL2_HUMAN, P60520Similarity: Belongs to the MAP1 LC3 family | Gene Function for GABARAPL2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007285
Applied Biosystems Silencer® siRNAs for GABARAPL2
Sigma-Aldrich siRNA for GABARAPL2  Sigma-Aldrich shRNA for GABARAPL2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_007285                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_007285                                  untagged cDNA clone in CMV expression vector: NM_007285 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_007285
UniProtKB/Swiss-Prot: GBRL2_HUMAN, P60520Function: Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity)5 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for GABARAPL2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for GABARAPL2 
5/24 Interacting proteins for GABARAPL2 (ENSP000000372433 P605201, 2) via UniProtKB, MINT, and/or STRING (see all 24
)About this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for GABARAPL2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for GABARAPL2
|
Transcripts for GABARAPL2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007285
Sigma-Aldrich siRNA for GABARAPL2  Sigma-Aldrich shRNA for GABARAPL2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_007285 REFSEQ mRNAs for GABARAPL2 gene: NM_007285.6
Applied Biosystems TaqMan ® Gene Expression Assays: NM_007285               OriGene GFP tagged cDNA clone in CMV expression vector: NM_007285                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_007285                                  untagged cDNA clone in CMV expression vector: NM_007285  Additional cDNA sequence: AB030710.1 AF077046.1 AF087848.1 AJ010569.1 AK289788.1 AK311266.1 BC005985.1 BC014594.2 BC029601.1 BC040312.1 CR542217.1 CR592344.1 CR603478.1 CR621062.1 CR624907.1 14 DOTS entries: DT.117538 DT.100791078 DT.100657358 DT.91764685 DT.120669693 DT.95161731 DT.100791075 DT.95161726 DT.100684495 DT.120669675 DT.120669800 DT.91764676 DT.91764672 DT.95161738 24/369 AceView cDNA sequences (see all 369
):CR603478 NM_007285 AA127496 CF456408 CA395633 CA389312 BM709773 BU661144 AI363487 AW571871 N66389 CA941995 AA152046 CR621062 BQ004090 AA149807 BM874519 AA400231 BU658824 AI702598 BQ774307 CR624907 AW264252 BU163903
highest scoring ESTs for GABARAPL2:AA063027 AA099173 AA101923 AA127496 AA127591 AA149807 AA149872 AA224361 AA282403 AA364905 Unigene Cluster for GABARAPL2: GABA(A) receptor-associated protein-like 2 Hs.461379 [show with all ESTs]Unigene Representative Sequence: BC040312
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for GABARAPL2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | |
| SP1: | |   | |   | - |   | |   | |   | - |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP3: | |   | |   | - |   | |   | - |   | - |   | |   | |   | |
| SP4: | |   | |   | - |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for GABARAPL2
1 Ensembl transcript including schematic representation: ENST00000037243
|
Expression for GABARAPL2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| GABARAPL2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for GABARAPL2
1 / 2 / 3 3 probe-sets matching GABARAPL2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TTGGACTGAG
SOURCE GeneReport for Unigene cluster: Hs.461379
Expression variation in blood from EXPOLDB for GABARAPL2 UniProtKB/Swiss-Prot: GBRL2_HUMAN, P60520Tissue specificity: Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine |
Orthologs for GABARAPL2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GABARAPL2 gene from 5/16 species (see all 16
)
About this table Species with no ortholog for GABARAPL2
ENSEMBL Gene Tree for GABARAPL2 | Paralogs for GABARAPL2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for GABARAPL2 gene
- MAP1LC3B2 MAP1LC3A2 MAP1LC3C2 MAP1LC3B22
|
SNPs/Variants for GABARAPL2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for GABARAPL2 (up to first 250kb)
|
Disorders & Mutations for GABARAPL2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 607452
|
Medical News for GABARAPL2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for GABARAPL2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/22 PubMed articles for GABARAPL2 gene (see all 22
):- Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein. (PubMed id 11414770)1, 2, 3, 4 Xin Y....Zhao S. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation. (PubMed id 11146101)3, 4 Okazaki N.... Muramatsu M.-A. (2000)
- The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. (PubMed id 18768753)3 Sou Y.S....Komatsu M. (2008)
- Autophagy-independent incorporation of GFP-LC3 into protein aggregates is dependent on its interaction with p62/SQSTM1. (PubMed id 18776740)3 Shvets E. and Elazar Z. (2008)
- Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry. (PubMed id 17287340)4 Molina H.... Pandey A. (2007)
- ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)4 Matsuoka S.... Elledge S.J. (2007)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)3 Ewing R.M....Figeys D. (2007)
- Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16. (PubMed id 16303767)3 Sou Y.S....Kominami E. (2006)
- The LIFEdb database in 2006. (PubMed id 16381901)3 Mehrle A....Wiemann S. (2006)
|
Search for GABARAPL2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing GABARAPL2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing GABARAPL2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GABARAPL2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for GABARAPL2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for GABARAPL2:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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