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Aliases for GABARAPL2 Gene

Aliases for GABARAPL2 Gene

  • GABA Type A Receptor Associated Protein Like 2 2 3 5
  • Golgi-Associated ATPase Enhancer Of 16 KDa 3 4
  • GABA(A) Receptor-Associated Protein-Like 2 3 4
  • General Protein Transport Factor P16 3 4
  • Ganglioside Expression Factor 2 3 4
  • GATE-16 3 4
  • GEF-2 3 4
  • GEF2 3 4
  • Gamma-Aminobutyric Acid Receptor-Associated Protein-Like 2 3
  • GABA(A) Receptor-Associated Protein Like 2 2
  • MAP1 Light Chain 3 Related Protein 3
  • MAP1 Light Chain 3-Related Protein 4
  • GATE16 3
  • ATG8C 3
  • FLC3A 4
  • ATG8 3

External Ids for GABARAPL2 Gene

Previous GeneCards Identifiers for GABARAPL2 Gene

  • GC16P066530
  • GC16P076560
  • GC16P075339
  • GC16P075380
  • GC16P075381
  • GC16P074157
  • GC16P075600
  • GC16P061353

Summaries for GABARAPL2 Gene

GeneCards Summary for GABARAPL2 Gene

GABARAPL2 (GABA Type A Receptor Associated Protein Like 2) is a Protein Coding gene. Diseases associated with GABARAPL2 include Neuronal Ceroid Lipofuscinosis and Amyotrophic Lateral Sclerosis Type 14. Among its related pathways are GABAergic synapse and FoxO signaling pathway. GO annotations related to this gene include microtubule binding and SNARE binding. An important paralog of this gene is GABARAPL1.

UniProtKB/Swiss-Prot for GABARAPL2 Gene

  • Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Gene Wiki entry for GABARAPL2 Gene

Additional gene information for GABARAPL2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GABARAPL2 Gene

Genomics for GABARAPL2 Gene

Regulatory Elements for GABARAPL2 Gene

Enhancers for GABARAPL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H075593 1.5 FANTOM5 Ensembl ENCODE 11.6 +28.0 27999 1 HDGF PKNOX1 ATF1 FOXA2 ARNT ZNF766 GATA2 FOS ATF7 RUNX3 GABARAPL2 TMEM231 ADAT1 PIR60653 GC16P075575
GH16H075516 1.4 ENCODE dbSUPER 11.2 -49.3 -49339 2 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ADAT1 TMEM231 RFWD3 CHST6 GABARAPL2 KARS LOC100420067 CHST5
GH16H075471 1.2 Ensembl ENCODE 10.8 -94.1 -94051 1 ELF3 PKNOX1 RB1 ARID4B ZNF2 RAD21 RFX5 SLC30A9 ZNF143 ZNF391 ENSG00000261783 WDR59 CHST6 CHST5 TMEM231 ENSG00000252122 GABARAPL2 CFDP1 ENSG00000203472 TMEM170A
GH16H075619 1.1 ENCODE 11.4 +55.3 55338 4 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ADAT1 BCAR1 GABARAPL2 TMEM231 CHST5 ENSG00000259992
GH16H075461 1.1 ENCODE 10.7 -102.7 -102731 3 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000261783 RFWD3 ADAT1 GABARAPL2 KARS CFDP1 BCAR1 ENSG00000261717 ENSG00000261476
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GABARAPL2 on UCSC Golden Path with GeneCards custom track

Promoters for GABARAPL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000088026 249 1601 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF143 SP3

Genomic Location for GABARAPL2 Gene

Chromosome:
16
Start:
75,566,351 bp from pter
End:
75,577,881 bp from pter
Size:
11,531 bases
Orientation:
Plus strand

Genomic View for GABARAPL2 Gene

Genes around GABARAPL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GABARAPL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GABARAPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GABARAPL2 Gene

Proteins for GABARAPL2 Gene

  • Protein details for GABARAPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60520-GBRL2_HUMAN
    Recommended name:
    Gamma-aminobutyric acid receptor-associated protein-like 2
    Protein Accession:
    P60520
    Secondary Accessions:
    • O08765
    • Q6FG91
    • Q9DCP8
    • Q9UQF7

    Protein attributes for GABARAPL2 Gene

    Size:
    117 amino acids
    Molecular mass:
    13667 Da
    Quaternary structure:
    • Monomer. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin (By similarity). Interacts with ATG3, ATG7, ATG13 and ULK1. Interacts with TP53INP1 and TP53INP2. Interacts with TBC1D25. Directly interacts with SQSTM1 and BNIP3. Interacts with TECPR2 and PCM1. Interacts with TBC1D5 (PubMed:22354992). Interacts with TRIM5 (PubMed:25127057). Interacts with MEFV and TRIM21 (PubMed:26347139).

    Three dimensional structures from OCA and Proteopedia for GABARAPL2 Gene

neXtProt entry for GABARAPL2 Gene

Post-translational modifications for GABARAPL2 Gene

  • The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.
  • The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL2-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL2-II. ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes.
  • Ubiquitination at posLast=2424
  • Modification sites at PhosphoSitePlus

Other Protein References for GABARAPL2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GABARAPL2 (GABARAPL2)

Protein Products

  • Novus Biologicals proteins for GABARAPL2
  • Cloud-Clone Corp. Proteins for GABARAPL2

No data available for DME Specific Peptides for GABARAPL2 Gene

Domains & Families for GABARAPL2 Gene

Gene Families for GABARAPL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GABARAPL2 Gene

Graphical View of Domain Structure for InterPro Entry

P60520

UniProtKB/Swiss-Prot:

GBRL2_HUMAN :
  • Belongs to the ATG8 family.
Family:
  • Belongs to the ATG8 family.
genes like me logo Genes that share domains with GABARAPL2: view

Function for GABARAPL2 Gene

Molecular function for GABARAPL2 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Phenotypes From GWAS Catalog for GABARAPL2 Gene

Gene Ontology (GO) - Molecular Function for GABARAPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding ISS 10747018
GO:0005515 protein binding IPI 11096062
GO:0008017 microtubule binding NAS 11414770
GO:0031625 ubiquitin protein ligase binding IPI 25127057
GO:0048487 beta-tubulin binding ISS --
genes like me logo Genes that share ontologies with GABARAPL2: view
genes like me logo Genes that share phenotypes with GABARAPL2: view

Animal Models for GABARAPL2 Gene

MGI Knock Outs for GABARAPL2:

Animal Model Products

CRISPR Products

miRNA for GABARAPL2 Gene

miRTarBase miRNAs that target GABARAPL2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GABARAPL2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GABARAPL2 Gene

Localization for GABARAPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GABARAPL2 Gene

Golgi apparatus. Cytoplasmic vesicle, autophagosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GABARAPL2 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
lysosome 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
plasma membrane 1
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GABARAPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA,ISS 10747018
GO:0000421 autophagosome membrane TAS --
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm IDA 21669198
GO:0005776 autophagosome IDA,IEA 19056683
genes like me logo Genes that share ontologies with GABARAPL2: view

Pathways & Interactions for GABARAPL2 Gene

genes like me logo Genes that share pathways with GABARAPL2: view

Pathways by source for GABARAPL2 Gene

1 GeneTex pathway for GABARAPL2 Gene
1 BioSystems pathway for GABARAPL2 Gene
1 R&D Systems pathway for GABARAPL2 Gene

SIGNOR curated interactions for GABARAPL2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for GABARAPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA --
GO:0000422 mitophagy IBA --
GO:0006810 transport IEA --
GO:0006891 intra-Golgi vesicle-mediated transport ISS 10747018
GO:0006914 autophagy IEA,NAS 12507496
genes like me logo Genes that share ontologies with GABARAPL2: view

Drugs & Compounds for GABARAPL2 Gene

(1) Drugs for GABARAPL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
gamma-Aminobutyric acid Investigational Pharma 254
genes like me logo Genes that share compounds with GABARAPL2: view

Transcripts for GABARAPL2 Gene

Unigene Clusters for GABARAPL2 Gene

GABA(A) receptor-associated protein-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for GABARAPL2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for GABARAPL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for GABARAPL2 Gene

GeneLoc Exon Structure for
GABARAPL2
ECgene alternative splicing isoforms for
GABARAPL2

Expression for GABARAPL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GABARAPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GABARAPL2 Gene

This gene is overexpressed in Brain (18.7), Fetal Brain (13.0), and Bone (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GABARAPL2 Gene



Protein tissue co-expression partners for GABARAPL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GABARAPL2 Gene:

GABARAPL2

SOURCE GeneReport for Unigene cluster for GABARAPL2 Gene:

Hs.461379

mRNA Expression by UniProt/SwissProt for GABARAPL2 Gene:

P60520-GBRL2_HUMAN
Tissue specificity: Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine.

Evidence on tissue expression from TISSUES for GABARAPL2 Gene

  • Nervous system(5)
  • Blood(2.7)
  • Muscle(2.6)
  • Kidney(2.2)
  • Liver(2.2)
  • Heart(2.1)
  • Intestine(2.1)
  • Adrenal gland(2)
  • Eye(2)
genes like me logo Genes that share expression patterns with GABARAPL2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GABARAPL2 Gene

Orthologs for GABARAPL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GABARAPL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GABARAPL2 33 34
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia GABARAPL2 33 34
  • 96.3 (n)
cow
(Bos Taurus)
Mammalia GABARAPL2 33 34
  • 95.44 (n)
rat
(Rattus norvegicus)
Mammalia Gabarapl2 33
  • 94.3 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GABARAPL2 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gabarapl2 33 16 34
  • 92.88 (n)
oppossum
(Monodelphis domestica)
Mammalia GABARAPL2 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves GABARAPL2 33 34
  • 85.19 (n)
lizard
(Anolis carolinensis)
Reptilia GABARAPL2 34
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gabarapl2 33
  • 84.2 (n)
zebrafish
(Danio rerio)
Actinopterygii gabarapl2 33 34
  • 79.77 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG8 34 36
  • 56 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ATG8B 33
  • 61.74 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5259 33
Species where no ortholog for GABARAPL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GABARAPL2 Gene

ENSEMBL:
Gene Tree for GABARAPL2 (if available)
TreeFam:
Gene Tree for GABARAPL2 (if available)

Paralogs for GABARAPL2 Gene

Paralogs for GABARAPL2 Gene

(9) SIMAP similar genes for GABARAPL2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for GABARAPL2 Gene

genes like me logo Genes that share paralogs with GABARAPL2: view

Variants for GABARAPL2 Gene

Sequence variations from dbSNP and Humsavar for GABARAPL2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000633577 -- 75,566,319(+) GCGCC(A/G)GAAGC upstream-variant-2KB
rs1000684617 -- 75,577,088(+) AAATG(G/T)CTTTG intron-variant
rs1000793207 -- 75,571,836(+) ACGCC(C/T)GGCTA intron-variant
rs1000986187 -- 75,564,594(+) TGGCT(C/G)ACACC upstream-variant-2KB
rs1001166473 -- 75,571,592(+) ACCCC(A/C)CACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GABARAPL2 Gene

Variant ID Type Subtype PubMed ID
nsv1063718 CNV gain 25217958
nsv1065995 CNV loss 25217958
nsv457521 CNV gain 19166990
nsv525955 CNV loss 19592680
nsv572979 CNV gain 21841781

Variation tolerance for GABARAPL2 Gene

Residual Variation Intolerance Score: 57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GABARAPL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GABARAPL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GABARAPL2 Gene

Disorders for GABARAPL2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GABARAPL2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neuronal ceroid lipofuscinosis
  • neuronal ceroid-lipofuscinoses
amyotrophic lateral sclerosis type 14
  • als14
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GABARAPL2

Genetic Association Database (GAD)
GABARAPL2
Human Genome Epidemiology (HuGE) Navigator
GABARAPL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GABARAPL2
genes like me logo Genes that share disorders with GABARAPL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GABARAPL2 Gene

Publications for GABARAPL2 Gene

  1. Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein. (PMID: 11414770) Xin Y … Zhao S (Genomics 2001) 2 3 4 22 60
  2. TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity. (PMID: 26347139) Kimura T … Deretic V (The Journal of cell biology 2015) 3 4 60
  3. TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition. (PMID: 25127057) Mandell MA … Deretic V (Developmental cell 2014) 3 4 60
  4. Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites. (PMID: 24089205) Tang Z … Zhong Q (Nature 2013) 3 4 60
  5. Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. (PMID: 22354992) Popovic D … Dikic I (Molecular and cellular biology 2012) 3 4 60

Products for GABARAPL2 Gene

Sources for GABARAPL2 Gene

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