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Aliases for GABARAPL2 Gene

Aliases for GABARAPL2 Gene

  • GABA Type A Receptor Associated Protein Like 2 2 3
  • GABA(A) Receptor-Associated Protein Like 2 2 3 5
  • Golgi-Associated ATPase Enhancer Of 16 KDa 3 4
  • GABA(A) Receptor-Associated Protein-Like 2 3 4
  • General Protein Transport Factor P16 3 4
  • MAP1 Light Chain 3-Related Protein 3 4
  • Ganglioside Expression Factor 2 3 4
  • GATE-16 3 4
  • GEF-2 3 4
  • GEF2 3 4
  • MAP1 Light Chain 3 Related Protein 3
  • GATE16 3
  • ATG8C 3
  • FLC3A 4
  • ATG8 3

External Ids for GABARAPL2 Gene

Previous GeneCards Identifiers for GABARAPL2 Gene

  • GC16P066530
  • GC16P076560
  • GC16P075339
  • GC16P075380
  • GC16P075381
  • GC16P074157
  • GC16P075600
  • GC16P061353

Summaries for GABARAPL2 Gene

GeneCards Summary for GABARAPL2 Gene

GABARAPL2 (GABA Type A Receptor Associated Protein Like 2) is a Protein Coding gene. Diseases associated with GABARAPL2 include Amyotrophic Lateral Sclerosis Type 14. Among its related pathways are Circadian entrainment and Regulation of autophagy. GO annotations related to this gene include microtubule binding and SNARE binding. An important paralog of this gene is MAP1LC3C.

UniProtKB/Swiss-Prot for GABARAPL2 Gene

  • Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Gene Wiki entry for GABARAPL2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GABARAPL2 Gene

Genomics for GABARAPL2 Gene

Regulatory Elements for GABARAPL2 Gene

Enhancers for GABARAPL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GABARAPL2 on UCSC Golden Path with GeneCards custom track

Promoters for GABARAPL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GABARAPL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GABARAPL2 Gene

Chromosome:
16
Start:
75,566,351 bp from pter
End:
75,577,881 bp from pter
Size:
11,531 bases
Orientation:
Plus strand

Genomic View for GABARAPL2 Gene

Genes around GABARAPL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GABARAPL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GABARAPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GABARAPL2 Gene

Proteins for GABARAPL2 Gene

  • Protein details for GABARAPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60520-GBRL2_HUMAN
    Recommended name:
    Gamma-aminobutyric acid receptor-associated protein-like 2
    Protein Accession:
    P60520
    Secondary Accessions:
    • O08765
    • Q6FG91
    • Q9DCP8
    • Q9UQF7

    Protein attributes for GABARAPL2 Gene

    Size:
    117 amino acids
    Molecular mass:
    13667 Da
    Quaternary structure:
    • Monomer. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin (By similarity). Interacts with ATG3, ATG7, ATG13 and ULK1. Interacts with TP53INP1 and TP53INP2. Interacts with TBC1D25. Directly interacts with SQSTM1 and BNIP3. Interacts with TECPR2 and PCM1. Interacts with TBC1D5 (PubMed:22354992). Interacts with TRIM5 (PubMed:25127057). Interacts with MEFV and TRIM21 (PubMed:26347139).

    Three dimensional structures from OCA and Proteopedia for GABARAPL2 Gene

neXtProt entry for GABARAPL2 Gene

Proteomics data for GABARAPL2 Gene at MOPED

Post-translational modifications for GABARAPL2 Gene

  • The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.
  • The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL2-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL2-II. ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes.
  • Ubiquitination at Lys 24
  • Modification sites at PhosphoSitePlus

Other Protein References for GABARAPL2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GABARAPL2 (GABARAPL2)

No data available for DME Specific Peptides for GABARAPL2 Gene

Domains & Families for GABARAPL2 Gene

Gene Families for GABARAPL2 Gene

Protein Domains for GABARAPL2 Gene

Graphical View of Domain Structure for InterPro Entry

P60520

UniProtKB/Swiss-Prot:

GBRL2_HUMAN :
  • Belongs to the ATG8 family.
Family:
  • Belongs to the ATG8 family.
genes like me logo Genes that share domains with GABARAPL2: view

Function for GABARAPL2 Gene

Molecular function for GABARAPL2 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
genes like me logo Genes that share phenotypes with GABARAPL2: view

Animal Models for GABARAPL2 Gene

MGI Knock Outs for GABARAPL2:

Animal Model Products

CRISPR Products

miRNA for GABARAPL2 Gene

miRTarBase miRNAs that target GABARAPL2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GABARAPL2 Gene

Localization for GABARAPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GABARAPL2 Gene

Golgi apparatus. Cytoplasmic vesicle, autophagosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GABARAPL2 Gene COMPARTMENTS Subcellular localization image for GABARAPL2 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
vacuole 5
lysosome 3
endoplasmic reticulum 2
endosome 2
mitochondrion 2
nucleus 2
cytoskeleton 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GABARAPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005776 autophagosome IDA 19056683
genes like me logo Genes that share ontologies with GABARAPL2: view

Pathways & Interactions for GABARAPL2 Gene

genes like me logo Genes that share pathways with GABARAPL2: view

Pathways by source for GABARAPL2 Gene

1 GeneTex pathway for GABARAPL2 Gene
1 BioSystems pathway for GABARAPL2 Gene
2 Reactome pathways for GABARAPL2 Gene
1 R&D Systems pathway for GABARAPL2 Gene

SIGNOR curated interactions for GABARAPL2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for GABARAPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA --
GO:0000422 mitophagy IBA --
GO:0006914 autophagy IEA,NAS 12507496
GO:0016236 macroautophagy TAS --
GO:0032781 positive regulation of ATPase activity ISS 10747018
genes like me logo Genes that share ontologies with GABARAPL2: view

Drugs & Compounds for GABARAPL2 Gene

(1) Drugs for GABARAPL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gamma-Aminobutyric acid Pharma 221
genes like me logo Genes that share compounds with GABARAPL2: view

Transcripts for GABARAPL2 Gene

Unigene Clusters for GABARAPL2 Gene

GABA(A) receptor-associated protein-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GABARAPL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for GABARAPL2 Gene

GeneLoc Exon Structure for
GABARAPL2
ECgene alternative splicing isoforms for
GABARAPL2

Expression for GABARAPL2 Gene

mRNA expression in normal human tissues for GABARAPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GABARAPL2 Gene

This gene is overexpressed in Brain (18.7), Fetal Brain (13.0), and Bone (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GABARAPL2 Gene



SOURCE GeneReport for Unigene cluster for GABARAPL2 Gene Hs.461379

mRNA Expression by UniProt/SwissProt for GABARAPL2 Gene

P60520-GBRL2_HUMAN
Tissue specificity: Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine.
genes like me logo Genes that share expression patterns with GABARAPL2: view

Protein tissue co-expression partners for GABARAPL2 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for GABARAPL2 Gene

Orthologs for GABARAPL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GABARAPL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GABARAPL2 35
  • 95.44 (n)
  • 100 (a)
GABARAPL2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GABARAPL2 35
  • 96.3 (n)
  • 100 (a)
GABARAPL2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gabarapl2 35
  • 92.88 (n)
  • 100 (a)
Gabarapl2 16
Gabarapl2 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GABARAPL2 35
  • 99.72 (n)
  • 100 (a)
GABARAPL2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gabarapl2 35
  • 94.3 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia GABARAPL2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GABARAPL2 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves GABARAPL2 35
  • 85.19 (n)
  • 99.15 (a)
GABARAPL2 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GABARAPL2 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gabarapl2 35
  • 84.2 (n)
  • 100 (a)
zebrafish
(Danio rerio)
Actinopterygii gabarapl2 35
  • 79.77 (n)
  • 96.58 (a)
gabarapl2 36
  • 97 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG8 36
  • 56 (a)
OneToMany
ATG8 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ATG8B 35
  • 61.74 (n)
  • 60 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5259 35
Species with no ortholog for GABARAPL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GABARAPL2 Gene

ENSEMBL:
Gene Tree for GABARAPL2 (if available)
TreeFam:
Gene Tree for GABARAPL2 (if available)

Paralogs for GABARAPL2 Gene

Paralogs for GABARAPL2 Gene

(9) SIMAP similar genes for GABARAPL2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for GABARAPL2 Gene

genes like me logo Genes that share paralogs with GABARAPL2: view

Variants for GABARAPL2 Gene

Sequence variations from dbSNP and Humsavar for GABARAPL2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs11556291 - 75,568,098(+) CTTGG(C/T)TCCAT reference, missense
rs2792 -- 75,577,738(-) TGGAT(A/G)ATTTT utr-variant-3-prime
rs8192515 -- 75,566,467(+) GTTCC(A/G)TCCCC utr-variant-5-prime
rs8192516 -- 75,566,587(+) CACTC(C/G)GGCGG intron-variant
rs8192517 -- 75,566,824(+) CGCGG(C/G)CGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GABARAPL2 Gene

Variant ID Type Subtype PubMed ID
nsv525955 CNV Loss 19592680
nsv457521 CNV Gain 19166990

Variation tolerance for GABARAPL2 Gene

Residual Variation Intolerance Score: 57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.93% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GABARAPL2 Gene

Disorders for GABARAPL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GABARAPL2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis type 14
  • als14
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GABARAPL2

Genetic Association Database (GAD)
GABARAPL2
Human Genome Epidemiology (HuGE) Navigator
GABARAPL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GABARAPL2
genes like me logo Genes that share disorders with GABARAPL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GABARAPL2 Gene

Publications for GABARAPL2 Gene

  1. Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein. (PMID: 11414770) Xin Y. … Zhao S. (Genomics 2001) 2 3 4 23 67
  2. CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling. (PMID: 25684205) Genau H.M. … Behrends C. (Mol. Cell 2015) 3
  3. Autophagy receptor NDP52 regulates pathogen-containing autophagosome maturation. (PMID: 25771791) Verlhac P. … Faure M. (Cell Host Microbe 2015) 3
  4. Regulation of endoplasmic reticulum turnover by selective autophagy. (PMID: 26040720) Khaminets A. … Dikic I. (Nature 2015) 3
  5. Conformational Polymorphism in Autophagy-Related Protein GATE-16. (PMID: 26284781) Ma P. … WeiergrAober O.H. (Biochemistry 2015) 3

Products for GABARAPL2 Gene

Sources for GABARAPL2 Gene

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