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GABARAPL2 Gene

protein-coding   GIFtS: 67
GCID: GC16P075600

GABA(A) Receptor-Associated Protein-Like 2

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
GABA(A) Receptor-Associated Protein-Like 21 2 3     MAP1 Light Chain 3-Related Protein2 3
Ganglioside Expression Factor 22 3     ATG82
General Protein Transport Factor P162 3     ATG8C2
Golgi-Associated ATPase Enhancer Of 16 KDa2 3     GATE162
GATE-162 3     Gamma-Aminobutyric Acid Receptor-Associated Protein-Like 22
GEF-22 3     MAP1 Light Chain 3 Related Protein2
GEF22 3     FLC3A3

External Ids:    HGNC: 132911   Entrez Gene: 113452   Ensembl: ENSG000000347137   OMIM: 6074525   UniProtKB: P605203   

Export aliases for GABARAPL2 gene to outside databases

Previous GC identifers: GC16P066530 GC16P076560 GC16P075339 GC16P075380 GC16P075381 GC16P074157 GC16P061353


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GABARAPL2 Gene:
GABARAPL2 (GABA(A) receptor-associated protein-like 2) is a protein-coding gene. Diseases associated with GABARAPL2 include neuronal ceroid lipofuscinosis, and anorexia nervosa. GO annotations related to this gene include microtubule binding and beta-tubulin binding. An important paralog of this gene is MAP1LC3B.

UniProtKB/Swiss-Prot: GBRL2_HUMAN, P60520
Function: Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through
coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn
stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which
contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to
fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in
elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in
autophagosome maturation

Gene Wiki entry for GABARAPL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the GABARAPL2 gene promoter:
         Sox5   HOXA3   Pax-5   NRSF form 1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   NRSF form 2   AREB6   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGABARAPL2 promoter sequence
   Search Chromatin IP Primers for GABARAPL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GABARAPL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q23.1   HGNC cytogenetic band: 16q22.1

GABARAPL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GABARAPL2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P075600:  view genomic region     (about GC identifiers)

Start:
75,600,249 bp from pter      End:
75,611,779 bp from pter
Size:
11,531 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GBRL2_HUMAN, P60520 (See protein sequence)
Recommended Name: Gamma-aminobutyric acid receptor-associated protein-like 2 precursor  
Size: 117 amino acids; 13667 Da
Subunit: Monomer. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin (By similarity). Interacts with ATG3, ATG7,
ATG13 and ULK1. Interacts with TP53INP1 and TP53INP2. Interacts with TBC1D25. Directly interacts with SQSTM1 and
BNIP3. Interacts with TECPR2 and PCM1
Secondary accessions: O08765 Q6FG91 Q9DCP8 Q9UQF7

Explore the universe of human proteins at neXtProt for GABARAPL2: NX_P60520

Explore proteomics data for GABARAPL2 at MOPED

Post-translational modifications: 

  • The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL2-I. This is activated by
    APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL2-II.
    ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes1
  • The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to
    reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine (By similarity)1
  • Ubiquitination2 at Lys24
  • Modification sites at PhosphoSitePlus

  • See GABARAPL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009216.1  
    ENSEMBL proteins: 
     ENSP00000037243   ENSP00000456773   ENSP00000457448   ENSP00000455606  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004241 Atg8_like

    Graphical View of Domain Structure for InterPro Entry P60520

    ProtoNet protein and cluster: P60520

    1 Blocks protein domain: IPB004241 Light chain 3 (LC3)

    UniProtKB/Swiss-Prot: GBRL2_HUMAN, P60520
    Similarity: Belongs to the ATG8 family


    GABARAPL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBRL2_HUMAN, P60520
    Function: Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through
    coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn
    stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which
    contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to
    fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in
    elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in
    autophagosome maturation

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding ISS10747018
    GO:0005515protein binding IPI11096062
    GO:0008017microtubule binding NAS11414770
    GO:0048487beta-tubulin binding ISS--
    GO:0050811GABA receptor binding NAS11414770
         
    GABARAPL2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GABARAPL2:
     Decreased Tat-dependent transc 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GABARAPL2
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    7 qRT-PCR Assays for microRNAs that regulate GABARAPL2:
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    SwitchGear 3'UTR luciferase reporter plasmidGABARAPL2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GBRL2_HUMAN, P60520: Golgi apparatus (By similarity). Cytoplasmic vesicle, autophagosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    vacuole5
    cytosol4
    golgi apparatus4
    nucleus2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane ISS10747018
    GO:0000421autophagic vacuole membrane IDA15169837
    GO:0005622intracellular IDA--
    GO:0005737cytoplasm IDA--
    GO:0005776autophagic vacuole IDA19056683

    GABARAPL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GABARAPL2 About    
    See pathways by source

    SuperPathContained pathways About
    1Circadian entrainment
    GABAergic synapse0.53
    2Senescence and Autophagy
    Senescence and Autophagy
    3Regulation of autophagy
    Regulation of autophagy
    4FoxO signaling pathway
    FoxO signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for GABARAPL2
        Senescence and Autophagy



    3 Kegg Pathways  (Kegg details for GABARAPL2):
        FoxO signaling pathway
    Regulation of autophagy
    GABAergic synapse


    GABARAPL2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including GABARAPL2: 
              Autophagy in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GABARAPL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GABARAPL2 (P605201, 2, 3 ENSP000000372434) via UniProtKB, MINT, STRING, and/or I2D (see all 433)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000045autophagic vacuole assembly ----
    GO:0006891intra-Golgi vesicle-mediated transport ISS10747018
    GO:0006914autophagy NAS12507496
    GO:0015031protein transport IEA--
    GO:0032781positive regulation of ATPase activity ISS10747018

    GABARAPL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for GABARAPL2 (GBRL2)

    1 HMDB Compound for GABARAPL2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Gamma-Aminobutyric acid3-Carboxypropylamine (see all 27)56-12-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GABARAPL2 gene: 
    NM_007285.6  

    Unigene Cluster for GABARAPL2:

    GABA(A) receptor-associated protein-like 2
    Hs.461379  [show with all ESTs]
    Unigene Representative Sequence: BC040312
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000037243(uc002fen.3 uc010cgy.3) ENST00000565057 ENST00000563744
    ENST00000568455 ENST00000565985
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    7 qRT-PCR Assays for microRNAs that regulate GABARAPL2:
    hsa-miR-935 hsa-miR-3658 hsa-miR-145 hsa-miR-32* hsa-miR-944 hsa-miR-455-3p hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidGABARAPL2 3' UTR sequence
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    Additional mRNA sequence: 

    AB030710.1 AF077046.1 AF087848.1 AJ010569.1 AK289788.1 AK311266.1 BC005985.1 BC014594.2 
    BC029601.1 BC040312.1 CR542217.1 

    14 DOTS entries:

    DT.117538  DT.100791078  DT.100657358  DT.91764685  DT.120669693  DT.95161731  DT.100791075  DT.95161726 
    DT.100684495  DT.120669675  DT.91764676  DT.120669800  DT.91764672  DT.95161738 

    Selected AceView cDNA sequences (see all 369):

    BU620533 CR542217 AI275664 CR624907 AA152046 BU660734 NM_007285 BU163903 
    Z38191 AF087848 CF456408 BU661144 AW264252 CR621062 AB030710 CR592344 
    BG032237 BQ215016 BF939987 AI446554 BQ271870 AI702598 W56750 CA395633 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GABARAPL2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
    SP1:              -                 -               
    SP2:                                -               
    SP3:              -           -     -               
    SP4:              -                                 


    ECgene alternative splicing isoforms for GABARAPL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GABARAPL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGACTGAG
    GABARAPL2 Expression
    About this image


    GABARAPL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    GABARAPL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GABARAPL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.461379

    UniProtKB/Swiss-Prot: GBRL2_HUMAN, P60520
    Tissue specificity: Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal
    muscle. Expressed at very low levels in lung, thymus and small intestine

        Pathway & Disease-focused RT2 Profiler PCR Array including GABARAPL2: 
              Autophagy in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABARAPL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GABARAPL2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gabarapl21 , 5 gamma-aminobutyric acid (GABA) A receptor-associated more1, 5 92.88(n)1
    100(a)1
      8 (58.19 cM)5
    937391  NM_026693.51  NP_080969.21 
     1119407035 
    chicken
    (Gallus gallus)
    Aves GABARAPL21 GABA(A) receptor-associated protein-like 2 85.19(n)
    99.15(a)
      770240  XM_001232688.3  XP_001232689.1 
    lizard
    (Anolis carolinensis)
    Reptilia GABARAPL26
    GABA(A) receptor-associated protein-like 2
    98(a)
    1 ↔ 1
    GL343483.1(254701-260172)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD255576.12   -- 85.4(n)    CD255576.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY398351.12   -- 80.86(n)    AY398351.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ATG8(YBL078C)4 Component of autophagosomes and Cvt vesicles; undergoes more   --   2(80731-80378) 852200  NP_009475.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATG8B1 ATG8B 61.74(n)
    60(a)
      825794  NM_178967.3  NP_849298.1 
    corn
    (Zea mays)
    Liliopsida AY109516.12   -- 74.55(n)    AY109516.1 


    ENSEMBL Gene Tree for GABARAPL2 (if available)
    TreeFam Gene Tree for GABARAPL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for GABARAPL2 gene
    MAP1LC3B2  MAP1LC3A2  GABARAP2  MAP1LC3C2  GABARAPL32  MAP1LC3B22  GABARAPL12  
    9 SIMAP similar genes for GABARAPL2 using alignment to 4 protein entries:     GBRL2_HUMAN (see all proteins):
    DKFZp586A1923    GABARAP    GABARAPL1    GABARAPL3    DKFZp762B153    MAP1LC3B2
    MAP1LC3A    MAP1LC3B    MAP1LC3C

    GABARAPL2 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for GABARAPL2
    PGOHUM00000245209 PGOHUM00000235671 PGOHUM00000249492


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GABARAPL2 (see all 307)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1844421801,2
    --75598254(+) TTTTTC/TGAAAT 1 -- us2k10--------
    rs1180758781,2
    F--75598520(+) GGGAGG/TCCGAG 1 -- us2k11Minor allele frequency- T:0.09NA 120
    rs71943331,2
    C,F--75598615(+) aattaG/Tctggg 1 -- us2k12Minor allele frequency- T:0.50WA NA 4
    rs1393556601,2
    C--75598782(+) ACAAAG/TAAACA 1 -- us2k10--------
    rs1500457571,2
    --75598783(+) CAAAGA/TAACAA 1 -- us2k10--------
    rs1895785251,2
    --75598828(+) TAAAAC/TAACAA 1 -- us2k10--------
    rs1926655991,2
    --75598837(+) AAAAAG/TACTTA 1 -- us2k10--------
    rs1840061501,2
    --75598869(+) AGCATC/TGATCA 1 -- us2k10--------
    rs118658741,2
    C,F,H--75598936(+) GGTGCA/GTCAGA 1 -- us2k18Minor allele frequency- G:0.02NS NA WA 580
    rs1889356331,2
    C--75598981(+) TAAGTC/GAATAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GABARAPL2 (75600249 - 75611779 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for GABARAPL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv525955CNV Loss19592680
    nsv457521CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GABARAPL2
    DNA2.0 Custom Variant and Variant Library Synthesis for GABARAPL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607452    OMIM disorders: --

    7 diseases for GABARAPL2:    
    About MalaCards
    neuronal ceroid lipofuscinosis    anorexia nervosa    hiv-1    cerebritis
    prostatitis    thyroiditis    neuronitis


    GABARAPL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GABARAPL2
    Human Genome Epidemiology (HuGE) Navigator: GABARAPL2 (2 documents)

    Export disorders for GABARAPL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GABARAPL2 gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with GABARAPL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein. (PubMed id 11414770)1, 2, 3, 9 Xin Y....Zhao S. (Genomics 2001)
    2. TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death. (PubMed id 22421968)1, 2 Seillier M.... Dusetti N.J. (Cell Death Differ. 2012)
    3. ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs. (PubMed id 23043107)1, 2 Alemu E.A.... Johansen T. (J. Biol. Chem. 2012)
    4. OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation. (PubMed id 21383079)1, 2 Itoh T.... Fukuda M. (J. Cell Biol. 2011)
    5. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    6. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PubMed id 19844255)1, 4 Dastani Z....Genest J. (Eur. J. Hum. Genet. 2010)
    7. Network organization of the human autophagy system. (PubMed id 20562859)1, 2 Behrends C....Harper J.W. (Nature 2010)
    8. The TP53INP2 protein is required for autophagy in mammalian cells. (PubMed id 19056683)1, 2 Nowak J.... Iovanna J.L. (Mol. Biol. Cell 2009)
    9. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. (PubMed id 15169837)1, 2 Kabeya Y....Yoshimori T. (J. Cell Sci. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11345 HGNC: 13291 AceView: GABARAPL2 Ensembl:ENSG00000034713 euGenes: HUgn11345
    ECgene: GABARAPL2 Kegg: 11345 H-InvDB: GABARAPL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GABARAPL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GABARAPL2 gene:
    Search GeneIP for patents involving GABARAPL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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