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Aliases for GABARAPL2 Gene

Aliases for GABARAPL2 Gene

  • GABA(A) Receptor-Associated Protein-Like 2 2 3 4
  • Golgi-Associated ATPase Enhancer Of 16 KDa 3 4
  • General Protein Transport Factor P16 3 4
  • MAP1 Light Chain 3-Related Protein 3 4
  • Ganglioside Expression Factor 2 3 4
  • GATE-16 3 4
  • GEF-2 3 4
  • GEF2 3 4
  • Gamma-Aminobutyric Acid Receptor-Associated Protein-Like 2 3
  • MAP1 Light Chain 3 Related Protein 3
  • GATE16 3
  • ATG8C 3
  • FLC3A 4
  • ATG8 3

External Ids for GABARAPL2 Gene

Summaries for GABARAPL2 Gene

GeneCards Summary for GABARAPL2 Gene

GABARAPL2 (GABA(A) Receptor-Associated Protein-Like 2) is a Protein Coding gene. Among its related pathways are FoxO signaling pathway and Circadian entrainment. GO annotations related to this gene include microtubule binding and beta-tubulin binding. An important paralog of this gene is MAP1LC3C.

UniProtKB/Swiss-Prot for GABARAPL2 Gene

  • Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Gene Wiki entry for GABARAPL2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GABARAPL2 Gene

Genomics for GABARAPL2 Gene

Genomic Location for GABARAPL2 Gene

Start:
75,566,351 bp from pter
End:
75,577,881 bp from pter
Size:
11,531 bases
Orientation:
Plus strand

Genomic View for GABARAPL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GABARAPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GABARAPL2 Gene

Regulatory Elements for GABARAPL2 Gene

Proteins for GABARAPL2 Gene

  • Protein details for GABARAPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60520-GBRL2_HUMAN
    Recommended name:
    Gamma-aminobutyric acid receptor-associated protein-like 2
    Protein Accession:
    P60520
    Secondary Accessions:
    • O08765
    • Q6FG91
    • Q9DCP8
    • Q9UQF7

    Protein attributes for GABARAPL2 Gene

    Size:
    117 amino acids
    Molecular mass:
    13667 Da
    Quaternary structure:
    • Monomer. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin (By similarity). Interacts with ATG3, ATG7, ATG13 and ULK1. Interacts with TP53INP1 and TP53INP2. Interacts with TBC1D25. Directly interacts with SQSTM1 and BNIP3. Interacts with TECPR2 and PCM1. Interacts with TBC1D5 (PubMed:22354992).

    Three dimensional structures from OCA and Proteopedia for GABARAPL2 Gene

neXtProt entry for GABARAPL2 Gene

Proteomics data for GABARAPL2 Gene at MOPED

Post-translational modifications for GABARAPL2 Gene

  • The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.
  • The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL2-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL2-II. ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys24

Other Protein References for GABARAPL2 Gene

No data available for DME Specific Peptides for GABARAPL2 Gene

Domains for GABARAPL2 Gene

Protein Domains for GABARAPL2 Gene

UniProtKB/Swiss-Prot:

GBRL2_HUMAN
Family:
  • Belongs to the ATG8 family.:
    • P60520
genes like me logo Genes that share domains with GABARAPL2: view

No data available for Gene Families for GABARAPL2 Gene

Function for GABARAPL2 Gene

Molecular function for GABARAPL2 Gene

UniProtKB/Swiss-Prot Function: Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Gene Ontology (GO) - Molecular Function for GABARAPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding ISS 10747018
GO:0005515 protein binding IPI 11096062
GO:0008017 microtubule binding NAS 11414770
GO:0048487 beta-tubulin binding ISS --
GO:0050811 GABA receptor binding NAS 11414770
genes like me logo Genes that share ontologies with GABARAPL2: view

Phenotypes for GABARAPL2 Gene

GenomeRNAi human phenotypes for GABARAPL2:
genes like me logo Genes that share phenotypes with GABARAPL2: view

miRNA for GABARAPL2 Gene

miRTarBase miRNAs that target GABARAPL2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GABARAPL2 Gene

Localization for GABARAPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GABARAPL2 Gene

Golgi apparatus. Cytoplasmic vesicle, autophagosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GABARAPL2 Gene COMPARTMENTS Subcellular localization image for GABARAPL2 gene
Compartment Confidence
vacuole 5
cytosol 4
golgi apparatus 4
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for GABARAPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane ISS 10747018
GO:0000407 pre-autophagosomal structure IBA --
GO:0000421 autophagic vacuole membrane IDA 15169837
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm IDA 21669198
genes like me logo Genes that share ontologies with GABARAPL2: view

Pathways for GABARAPL2 Gene

genes like me logo Genes that share pathways with GABARAPL2: view

Pathways by source for GABARAPL2 Gene

1 BioSystems pathway for GABARAPL2 Gene

Gene Ontology (GO) - Biological Process for GABARAPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly IBA --
GO:0000422 mitochondrion degradation IBA --
GO:0006891 intra-Golgi vesicle-mediated transport ISS 10747018
GO:0006914 autophagy NAS 12507496
GO:0006995 cellular response to nitrogen starvation IBA --
genes like me logo Genes that share ontologies with GABARAPL2: view

Compounds for GABARAPL2 Gene

(1) HMDB Compounds for GABARAPL2 Gene

Compound Synonyms Cas Number PubMed IDs
Gamma-Aminobutyric acid
  • 3-Carboxypropylamine
56-12-2
genes like me logo Genes that share compounds with GABARAPL2: view

Transcripts for GABARAPL2 Gene

Unigene Clusters for GABARAPL2 Gene

GABA(A) receptor-associated protein-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GABARAPL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for GABARAPL2 Gene

GeneLoc Exon Structure for
GABARAPL2
ECgene alternative splicing isoforms for
GABARAPL2

Expression for GABARAPL2 Gene

mRNA expression in normal human tissues for GABARAPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GABARAPL2 Gene

SOURCE GeneReport for Unigene cluster for GABARAPL2 Gene Hs.461379

mRNA Expression by UniProt/SwissProt for GABARAPL2 Gene

P60520-GBRL2_HUMAN
Tissue specificity: Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine.
genes like me logo Genes that share expressions with GABARAPL2: view

Orthologs for GABARAPL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GABARAPL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GABARAPL2 36
  • 99.72 (n)
  • 100 (a)
GABARAPL2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GABARAPL2 36
  • 95.44 (n)
  • 100 (a)
GABARAPL2 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GABARAPL2 36
  • 96.3 (n)
  • 100 (a)
GABARAPL2 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gabarapl2 36
  • 92.88 (n)
  • 100 (a)
Gabarapl2 16
Gabarapl2 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GABARAPL2 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GABARAPL2 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gabarapl2 36
  • 94.3 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves GABARAPL2 36
  • 85.19 (n)
  • 99.15 (a)
GABARAPL2 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GABARAPL2 37
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gabarapl2 36
  • 84.2 (n)
  • 100 (a)
zebrafish
(Danio rerio)
Actinopterygii gabarapl2 36
  • 79.77 (n)
  • 96.58 (a)
gabarapl2 37
  • 97 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG8 37
  • 56 (a)
OneToMany
ATG8 39
thale cress
(Arabidopsis thaliana)
eudicotyledons ATG8B 36
  • 61.74 (n)
  • 60 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5259 36
Species with no ortholog for GABARAPL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GABARAPL2 Gene

ENSEMBL:
Gene Tree for GABARAPL2 (if available)
TreeFam:
Gene Tree for GABARAPL2 (if available)

Paralogs for GABARAPL2 Gene

Paralogs for GABARAPL2 Gene

Selected SIMAP similar genes for GABARAPL2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for GABARAPL2 Gene

genes like me logo Genes that share paralogs with GABARAPL2: view

Variants for GABARAPL2 Gene

Sequence variations from dbSNP and Humsavar for GABARAPL2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2792 -- 75,577,738(-) TGGAT(A/G)ATTTT utr-variant-3-prime
rs1043543 -- 75,566,479(+) TCCCG(C/T)CGCCG utr-variant-5-prime
rs1166208 -- 75,571,779(-) gaatc(A/G)cttga intron-variant
rs2164246 -- 75,568,471(+) AAAAC(A/G)GTTGA intron-variant
rs3743603 -- 75,572,316(+) CTGCC(C/T)TGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GABARAPL2 Gene

Variant ID Type Subtype PubMed ID
nsv525955 CNV Loss 19592680
nsv457521 CNV Gain 19166990

Relevant External Links for GABARAPL2 Gene

HapMap Linkage Disequilibrium report
GABARAPL2

Disorders for GABARAPL2 Gene

Relevant External Links for GABARAPL2

Genetic Association Database (GAD)
GABARAPL2
Human Genome Epidemiology (HuGE) Navigator
GABARAPL2
genes like me logo Genes that share disorders with GABARAPL2: view

No data available for UniProtKB/Swiss-Prot for GABARAPL2 Gene

Publications for GABARAPL2 Gene

  1. Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein. (PMID: 11414770) Xin Y. … Zhao S. (Genomics 2001) 2 3 4 23
  2. The human homolog of Saccharomyces cerevisiae Apg7p is a Protein- activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3. (PMID: 11096062) Tanida I. … Kominami E. (J. Biol. Chem. 2001) 3 4
  3. Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation. (PMID: 11146101) Okazaki N. … Muramatsu M.-A. (Brain Res. Mol. Brain Res. 2000) 3 4
  4. Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p. (PMID: 11825910) Tanida I. … Kominami E. (J. Biol. Chem. 2002) 3 4
  5. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. (PMID: 15169837) Kabeya Y. … Yoshimori T. (J. Cell Sci. 2004) 3 4

Products for GABARAPL2 Gene

Sources for GABARAPL2 Gene

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