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Aliases & Descriptions for GABARAPL1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| APG8-LIKE 2 | | APG8L 1, 2 | | ATG8 2 | | ATG8L 1, 2 | | GEC-1 3 | | GEC1 2, 3, 5 | | gec1 1 |
| | | Descriptions |
|---|
| Early estrogen-regulated protein 2, 3 | | GABA(A) receptor-associated protein like 1 2 | | GABA(A) receptor-associated protein-like 1 3 | | Glandular epithelial cell protein 1 3 |
|
| | Search outside databases for aliases for GABARAPL1 genePrevious GC identifers: GC12P010048 GC12P010488 GC12P010265 |
Summaries for GABARAPL1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: GBRL1_HUMAN, Q9H0R8Function: Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor |
Genomic Location for GABARAPL1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the GABARAPL1 gene 
Entrez Gene cytogenetic band: 12p13.2 Ensembl cytogenetic band: 12p13.2 HGNC cytogenetic band: 12p13.31GABARAPL1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P010256:
(about GC identifiers)
Start:
|
10,256,756 bp from pter |
End:
|
10,266,994 bp from pter |
Size:
|
10,239 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000012.10 NT_009714.16
| Proteins for GABARAPL1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: GBRL1_HUMAN, Q9H0R8 (See
protein sequence)Recommended Name: Gamma-aminobutyric acid receptor-associated protein-like 1 Size: 117 amino acids; 14044 Da
Subunit: Interacts with GABRG2 and beta-tubulin (By similarity). Interacts with OPRK1
Subcellular location: Cytoplasm. Membrane (By similarity). Endoplasmic reticulum (By similarity). Golgi apparatus (By similarity)
PDB structures from and Proteopedia :2R2Q (3D)
 
Secondary accessions: Q6FIE6Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_113600.1
ENSEMBL proteins: ENSP00000266458
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7
): About this table
Antibodies for GABARAPL1: Assays for GABARAPL1: | Protein
Domains/ Families for GABARAPL1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9H0R8
ProtoNet protein and cluster: Q9H0R8 1 Blocks protein family: IPB004241 Light chain 3 (LC3)
UniProtKB/Swiss-Prot: GBRL1_HUMAN, Q9H0R8Similarity: Belongs to the MAP1 LC3 family | Gene Function for GABARAPL1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_031412
Applied Biosystems Silencer® siRNAs for GABARAPL1
Sigma-Aldrich siRNA and siRNA Panels for GABARAPL1  Sigma-Aldrich shRNA for GABARAPL1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_031412                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_031412                                  untagged cDNA clone in CMV expression vector: NM_031412 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_031412
UniProtKB/Swiss-Prot: GBRL1_HUMAN, Q9H0R8Function: Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for GABARAPL1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for GABARAPL1 
5/8 Interacting proteins for GABARAPL1 (ENSP000002664583 Q9H0R81, 2) via UniProtKB, MINT, and/or STRING (see all 8
)About this table
|
Drugs & Compounds for GABARAPL1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for GABARAPL1
|
Transcripts for GABARAPL1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_031412
Sigma-Aldrich siRNA and siRNA Panels for GABARAPL1  Sigma-Aldrich shRNA for GABARAPL1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_031412 REFSEQ mRNAs for GABARAPL1 gene: NM_031412.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_031412               OriGene GFP tagged cDNA clone in CMV expression vector: NM_031412                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_031412                                  untagged cDNA clone in CMV expression vector: NM_031412  Additional cDNA sequence: AF087847.1 AF287012.1 AK056846.1 AK074195.1 AK092075.1 AK124150.1 AK303581.1 AK315418.1 AL136676.1 BC008891.2 BC009309.2 BC028315.1 BX648781.1 CR533480.1 CR591381.1 CR593137.1 CR595003.1 CR598360.1 CR599698.1 CR602506.1 CR602628.1 CR605097.1 CR605544.1 CR610376.1 CR611326.1 CR612549.1 CR615029.1 CR616129.1 CR616417.1 CR618651.1 CR618974.1 CR619385.1 CR619810.1 CR619851.1 CR620458.1 CR621758.1 CR622237.1 CR622348.1 CR622808.1 CR623363.1 CR623491.1 CR624199.1 CR624563.1 CR626218.1 CR626234.1 24/31 DOTS entries (see all 31
): DT.40195388 DT.100879636 DT.100031425 DT.91650894 DT.100879666 DT.101985482 DT.121210432 DT.100879661 DT.100879627 DT.40204612 DT.121210517 DT.100879644 DT.121210447 DT.121210463 DT.100684731 DT.100879663 DT.121210422 DT.121210469 DT.92456805 DT.95249234 DT.95362600 DT.100879647 DT.121210431 DT.121210437 24/579 AceView cDNA sequences (see all 579
):AA320994 CR619810 CR595003 AL558269 AA968835 CR616417 BP346505 AW883432 CR619851 BQ083511 AA937130 CA455333 CA392796 AI266094 CR624563 BF724643 CD517627 BF509254 AI381992 BU727972 CR615029 CR605097 CR591381 BM702215
highest scoring ESTs for GABARAPL1:W28281 AA055424 AA100616 AA186715 AA191585 AA195569 AA210963 AA211153 AA227494 AA242922 Unigene Cluster for GABARAPL1: GABA(A) receptor-associated protein like 1 Hs.524250 [show with all ESTs]Unigene Representative Sequence: BX648781
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for GABARAPL1 (see all 12
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | · | 10c | · | 10d | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for GABARAPL1
1 Ensembl transcript including schematic representation: ENST00000266458
|
Expression for GABARAPL1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| GABARAPL1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for GABARAPL1
1 / 2 / 3 7 probe-sets matching GABARAPL1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ACATTTCAAT
SOURCE GeneReport for Unigene cluster: Hs.524250
Expression variation in blood from EXPOLDB for GABARAPL1 UniProtKB/Swiss-Prot: GBRL1_HUMAN, Q9H0R8Tissue specificity: Ubiquitous. Expressed at very high levels in the brain, heart, peripheral blood leukocytes, liver, kidney, placenta and skeletal muscle. Expressed at very low levels in thymus and small intestine |
Orthologs for GABARAPL1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GABARAPL1 gene from 5/14 species (see all 14
)
About this table Species with no ortholog for GABARAPL1
ENSEMBL Gene Tree for GABARAPL1 | Paralogs for GABARAPL1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for GABARAPL1 gene
- GABARAP2
|
SNPs/Variants for GABARAPL1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for GABARAPL1 (up to first 250kb)
|
Disorders & Mutations for GABARAPL1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 607420
|
Medical News for GABARAPL1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for GABARAPL1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/23 PubMed articles for GABARAPL1 gene (see all 23
):- A novel early estrogen-regulated gene gec1 encodes a protein related to GABARAP. (PubMed id 11374880)1, 2, 3, 4 Vernier-Magnin S....Fraichard A. (2001)
- Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein. (PubMed id 11414770)1, 2, 3, 4 Xin Y....Zhao S. (2001)
- GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor. (PubMed id 16431922)3, 4 Chen C....Liu-Chen L.Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)3, 4 Wiemann S.... Poustka A. (2001)
- Identification and characterization of an early estrogen-regulated RNA in cultured guinea-pig endometrial cells. (PubMed id 8495796)1, 3 Pellerin I....Adessi G.L. (1993)
- Atg8L/Apg8L is the fourth mammalian modifier of mammalian Atg8 conjugation mediated by human Atg4B, Atg7 and Atg3. (PubMed id 16704426)1, 3 Tanida I....Kominami E. (2006)
- GEC1-kappa opioid receptor binding involves hydrophobic interactions: GEC1 has chaperone-like effect. (PubMed id 19001416)3 Chen Y....Liu-Chen L.Y. (2009)
- The LIFEdb database in 2006. (PubMed id 16381901)3 Mehrle A....Wiemann S. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)3 Rual J.F....Vidal M. (2005)
|
Search for GABARAPL1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing GABARAPL1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing GABARAPL1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GABARAPL1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for GABARAPL1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for GABARAPL1:

|
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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