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GABARAP Gene

protein-coding   GIFtS: 66
GCID: GC17M007143

GABA(A) Receptor-Associated Protein

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
GABA(A) Receptor-Associated Protein1 2 3
MM462 3
ATG8A2
GABARAP-a2
Gamma-Aminobutyric Acid Receptor-Associated Protein2
FLC3B3

External Ids:    HGNC: 40671   Entrez Gene: 113372   Ensembl: ENSG000001702967   OMIM: 6051255   UniProtKB: O951663   

Export aliases for GABARAP gene to outside databases

Previous GC identifers: GC16M055704 GC17M007873 GC17M007086 GC17M007344 GC17M007084 GC17M007035


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GABARAP Gene:
Gamma-aminobutyric acid A receptors (GABA(A) receptors) are ligand-gated chloride channels that mediate inhibitory
neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in
its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B.
This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. (provided by
RefSeq, Jul 2008)

GeneCards Summary for GABARAP Gene:
GABARAP (GABA(A) receptor-associated protein) is a protein-coding gene. Diseases associated with GABARAP include stiff-person syndrome, and essential tremor. GO annotations related to this gene include microtubule binding and GABA receptor binding. An important paralog of this gene is GABARAPL2.

UniProtKB/Swiss-Prot: GBRAP_HUMAN, O95166
Function: Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its
interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in
elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in
autophagosome maturation

Gene Wiki entry for GABARAP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the GABARAP gene promoter:
         COUP-TF1   AP-2alpha isoform 3   COUP   HNF-4alpha2   AP-2alpha isoform 2   HNF-4alpha1   COUP-TF   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGABARAP promoter sequence
   Search Chromatin IP Primers for GABARAP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GABARAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

GABARAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GABARAP gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007143:  view genomic region     (about GC identifiers)

Start:
7,143,333 bp from pter      End:
7,146,089 bp from pter
Size:
2,757 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GBRAP_HUMAN, O95166 (See protein sequence)
Recommended Name: Gamma-aminobutyric acid receptor-associated protein precursor  
Size: 117 amino acids; 13918 Da
Subunit: Interacts with GPHN and NSF (By similarity). Interacts with ATG3, ATG7, ATG13, RB1CC1, GABRG2,
beta-tubulin and ULK1. Interacts with CALR. Interacts with DDX47. Interacts with TP53INP1 and TP53INP2. Interacts
with TBC1D25. Directly interacts with SQSTM1. Interacts with MAPK15. Interacts with TECPR2 and PCM1
6 PDB 3D structures from and Proteopedia for GABARAP:
1GNU (3D)        1KLV (3D)        1KM7 (3D)        1KOT (3D)        3D32 (3D)        3DOW (3D)    

Explore the universe of human proteins at neXtProt for GABARAP: NX_O95166

Explore proteomics data for GABARAP at MOPED

Post-translational modifications: 

  • The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAP-I. This is activated by APG7L/ATG7,
    transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAP-II1
  • Ubiquitination2 at Lys24
  • Modification sites at PhosphoSitePlus

  • See GABARAP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009209.1  
    ENSEMBL proteins: 
     ENSP00000306866   ENSP00000460855   ENSP00000460489   ENSP00000461882   ENSP00000459345  
     ENSP00000458476  

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    Cloud-Clone Corp. CLIAs for GABARAP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004241 Atg8_like

    Graphical View of Domain Structure for InterPro Entry O95166

    ProtoNet protein and cluster: O95166

    1 Blocks protein domain: IPB004241 Light chain 3 (LC3)

    UniProtKB/Swiss-Prot: GBRAP_HUMAN, O95166
    Similarity: Belongs to the ATG8 family


    GABARAP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GBRAP_HUMAN, O95166
    Function: Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its
    interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in
    elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in
    autophagosome maturation

         Genatlas biochemistry entry for GABARAP:
    GABA (A) receptor-associated protein binding GABA-A receptors,gamma 2 subunit and linking the receptors to the
    cytoskeleton,highly homolog to microtubule associated proteins 1A and 1B ganglioside expression factor homolog 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11096062
    GO:0008017microtubule binding IEA--
    GO:0048487beta-tubulin binding IDA9892355
    GO:0050811GABA receptor binding IPI9892355
         
    GABARAP for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Gabarap):
     normal 

    GABARAP for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GABARAP
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GABARAP
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    miRTarBase miRNAs that target GABARAP:
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    Selected qRT-PCR Assays for microRNAs that regulate GABARAP (see all 15):
    hsa-miR-4303 hsa-miR-455-5p hsa-miR-550a hsa-miR-2114 hsa-miR-3606 hsa-miR-1321 hsa-miR-4306 hsa-miR-876-3p
    SwitchGear 3'UTR luciferase reporter plasmidGABARAP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GABARAP

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GBRAP_HUMAN, O95166: Endomembrane system (By similarity). Cytoplasm, cytoskeleton (By similarity). Golgi
    apparatus membrane (By similarity). Cytoplasmic vesicle, autophagosome. Note=Largely associated with
    intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae. Colocalizes with
    microtubules (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    vacuole5
    plasma membrane4
    cytoskeleton3
    cytosol3
    endoplasmic reticulum2
    golgi apparatus2
    lysosome2
    nucleus2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0000421autophagic vacuole membrane IDA15169837
    GO:0005737cytoplasm ----
    GO:0005764lysosome IEA--
    GO:0005776autophagic vacuole IDA19056683

    GABARAP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GABARAP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Circadian entrainment
    GABAergic synapse0.53
    2Senescence and Autophagy
    Senescence and Autophagy
    3Regulation of autophagy
    Regulation of autophagy
    4FoxO signaling pathway
    FoxO signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for GABARAP
        Senescence and Autophagy



    3 Kegg Pathways  (Kegg details for GABARAP):
        FoxO signaling pathway
    Regulation of autophagy
    GABAergic synapse


    GABARAP for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including GABARAP: 
              Autophagy in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GABARAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GABARAP (O951661, 2, 3 ENSP000003068664) via UniProtKB, MINT, STRING, and/or I2D (see all 714)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000045autophagic vacuole assembly ----
    GO:0000226microtubule cytoskeleton organization IEA--
    GO:0006605protein targeting TAS9892355
    GO:0006914autophagy IEA--
    GO:0007268synaptic transmission TAS9892355

    GABARAP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GABARAP (GBRAP)

    1 HMDB Compound for GABARAP    About this table
    CompoundSynonyms CAS #PubMed Ids
    Gamma-Aminobutyric acid3-Carboxypropylamine (see all 27)56-12-2--

    3 Novoseek inferred chemical compound relationships for GABARAP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gaba 70.2 45 9892355 (3), 18160640 (3), 15007071 (2), 16954214 (2) (see all 20)
    n-ethylmaleimide 42.6 3 15065816 (1), 11779480 (1), 18464608 (1)
    diazepam 38.4 3 19703932 (2), 15007071 (1)



    GABARAP for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GABARAP gene: 
    NM_007278.1  

    Unigene Cluster for GABARAP:

    GABA(A) receptor-associated protein
    Hs.647421  [show with all ESTs]
    Unigene Representative Sequence: BM803698
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302386(uc002gfb.3) ENST00000577035 ENST00000570856 ENST00000571129
    ENST00000571253 ENST00000573928

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    hsa-miR-4303 hsa-miR-455-5p hsa-miR-550a hsa-miR-2114 hsa-miR-3606 hsa-miR-1321 hsa-miR-4306 hsa-miR-876-3p
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    Additional mRNA sequence: 

    AB030711.1 AF044671.1 AF067171.1 AF161586.1 AF183425.1 AK098634.1 AK312205.1 AL050182.1 
    BC106748.1 BC106749.1 CR457043.1 CR542235.1 JN663880.1 

    Selected DOTS entries (see all 28):

    DT.99926443  DT.91773251  DT.100649015  DT.449606  DT.101985433  DT.120968637  DT.120968722  DT.91773230 
    DT.99937435  DT.120968554  DT.120968747  DT.120968788  DT.75111082  DT.100848809  DT.95271157  DT.120968638 
    DT.120968758  DT.95271171  DT.450749  DT.95127999  DT.95271155  DT.100848801  DT.120968719  DT.91773237 

    Selected AceView cDNA sequences (see all 672):

    BM977670 AI186350 CR606307 AI271664 CR625645 BG746404 CB851489 AA931271 
    AI365977 BF529506 AA284321 AI342966 BU179461 AA284614 BU656919 BM680789 
    CB216445 CN484963 CD675069 BQ432092 AA411012 BF844591 BU162758 BQ642912 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GABARAP    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
    SP1:              -                 -               
    SP2:              -                                 
    SP3:              -     -           -               
    SP4:                                -               


    ECgene alternative splicing isoforms for GABARAP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GABARAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAAGACTT
    GABARAP Expression
    About this image

    GABARAP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GABARAP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.647421

    UniProtKB/Swiss-Prot: GBRAP_HUMAN, O95166
    Tissue specificity: Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Array including GABARAP: 
              Autophagy in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GABARAP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GABARAP gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gabarap1 , 5 gamma-aminobutyric acid receptor associated protein1, 5 95.44(n)1
    100(a)1
      11 (42.95 cM)5
    564861  NM_019749.41  NP_062723.11 
     699911435 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    31(a)
    many ↔ many
    GL343198.1(4793321-4804105)
    zebrafish
    (Danio rerio)
    Actinopterygii gabarapa1 GABA(A) receptor-associated protein a 81.9(n)
    98.28(a)
      326974  NM_001013260.1  NP_001013278.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG123343   -- 77(a)   90C2   --
    worm
    (Caenorhabditis elegans)
    Secernentea lgg-13   -- 83(a)   II(6346634-6347795)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ATG86
    Component of autophagosomes and Cvt vesicles; unde...
    55(a)
    1 → many
    II(80378-80731) YBL078C


    ENSEMBL Gene Tree for GABARAP (if available)
    TreeFam Gene Tree for GABARAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GABARAP gene
    GABARAPL22  MAP1LC3B2  MAP1LC3A2  MAP1LC3C2  GABARAPL32  MAP1LC3B22  GABARAPL12  
    9 SIMAP similar genes for GABARAP using alignment to 5 protein entries:     GBRAP_HUMAN (see all proteins):
    DKFZp586A1923    GABARAPL3    GABARAPL1    GABARAPL2    DKFZp762B153    MAP1LC3B2
    MAP1LC3A    MAP1LC3B    MAP1LC3C

    GABARAP for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for GABARAP
    PGOHUM00000239887 PGOHUM00000245177


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GABARAP (see all 42)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1452812781,2
    --7144858(+) CCTCCA/TCCCGC 1 -- int10--------
    rs1118925721,2
    C--7144919(+) TCCCAA/CCTGTG 1 -- spd10--------
    rs21345101,2
    C,H--7144991(-) GATAGT/CAGAAA 2 /A /V mis17Minor allele frequency- C:0.00NS EA NA 588
    rs81925111,2
    C--7145052(-) GACAGG/ATGCAG 1 -- int12Minor allele frequency- A:0.00NA 4
    rs116563231,2
    C,F,H--7145117(+) TTGTCT/CTTGTA 1 -- int115Minor allele frequency- C:0.03NS EA NA WA 2218
    rs1829302901,2
    --7145169(+) GACTGA/GAGCTC 1 -- int10--------
    rs752101721,2
    C--7145230(+) ATCTT-/AATC  
            
    AGACG
    1 -- int10--------
    rs2020326951,2
    C--7145231(+) TCTTAA/GTCAGA 1 -- int10--------
    rs72160471,2
    C,F,A,H--7145281(+) GCAACC/GTTAGC 1 -- int115Minor allele frequency- G:0.23NS EA NA WA CSA 1487
    rs1868936471,2
    --7145304(+) TGACCA/GTTTGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for GABARAP (7143333 - 7146089 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for GABARAP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665200CNV Deletion23128226
    esv2422288CNV Deletion17116639
    nsv907637CNV Loss21882294
    dgv3053n71CNV Loss21882294
    nsv457659CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GABARAP
    DNA2.0 Custom Variant and Variant Library Synthesis for GABARAP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605125    OMIM disorders: --

    15 diseases for GABARAP:    About MalaCards
    stiff-person syndrome    essential tremor    tremor    nicotine dependence
    lynch syndrome    fibrosarcoma    mental retardation    neuroblastoma
    sarcoma    colorectal cancer    hiv-1    malaria
    breast cancer    neuronitis    thyroiditis

    4 diseases from the University of Copenhagen DISEASES database for GABARAP:
    Stiff-Person syndrome     Breast cancer     Fibrosarcoma     Sarcoma

    GABARAP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    1 Novoseek inferred disease relationship for GABARAP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 19617690 (1)

    Genetic Association Database (GAD): GABARAP
    Human Genome Epidemiology (HuGE) Navigator: GABARAP (3 documents)

    Export disorders for GABARAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GABARAP gene, integrated from 10 sources (see all 111):
    (articles sorted by number of sources associating them with GABARAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton. (PubMed id 9892355)1, 2, 3, 9 Wang H.... Olsen R.W. (Nature 1999)
    2. The X-ray crystal structure and putative ligand-derived peptide binding properties of gamma-aminobutyric acid receptor type A receptor-associated protein. (PubMed id 11729197)1, 2, 9 Knight D.... Keep N.H. (J. Biol. Chem. 2002)
    3. Structural framework of the GABARAP-calreticulin interface -- implications for substrate binding to endoplasmic reticulum chaperones. (PubMed id 19154346)1, 2, 9 Thielmann Y.... Willbold D. (FEBS J. 2009)
    4. Solution structure of human GABA(A) receptor-associated protein GABARAP: implications for biological function and its regulation. (PubMed id 11875056)1, 2, 9 Stangler T.... Willbold D. (J. Biol. Chem. 2002)
    5. Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p. (PubMed id 11825910)1, 2, 9 Tanida I.... Kominami E. (J. Biol. Chem. 2002)
    6. The TP53INP2 protein is required for autophagy in mammalian cells. (PubMed id 19056683)1, 2, 9 Nowak J.... Iovanna J.L. (Mol. Biol. Cell 2009)
    7. 1H, 13C and '5N resonance assignments of GABARAP, GABAA receptor associated protein. (PubMed id 11885988)1, 2, 9 Kouno T.... Kawano K. (J. Biomol. NMR 2002)
    8. The human homolog of Saccharomyces cerevisiae Apg7p is a Protein- activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3. (PubMed id 11096062)1, 2, 9 Tanida I.... Kominami E. (J. Biol. Chem. 2001)
    9. MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins. (PubMed id 22948227)1, 2 Colecchia D.... Chiariello M. (Autophagy 2012)
    10. ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs. (PubMed id 23043107)1, 2 Alemu E.A.... Johansen T. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11337 HGNC: 4067 AceView: CLDN7andGABARAPandDULLARD Ensembl:ENSG00000170296 euGenes: HUgn11337
    ECgene: GABARAP Kegg: 11337 H-InvDB: GABARAP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GABARAP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GABARAP gene:
    Search GeneIP for patents involving GABARAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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