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Aliases for GABARAP Gene

Aliases for GABARAP Gene

  • GABA(A) Receptor-Associated Protein 2 3 4
  • MM46 3 4
  • Gamma-Aminobutyric Acid Receptor-Associated Protein 3
  • GABARAP-A 3
  • ATG8A 3
  • FLC3B 4

External Ids for GABARAP Gene

Previous GeneCards Identifiers for GABARAP Gene

  • GC16M055704
  • GC17M007873
  • GC17M007086
  • GC17M007344
  • GC17M007084
  • GC17M007143
  • GC17M007035

Summaries for GABARAP Gene

Entrez Gene Summary for GABARAP Gene

  • Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008]

GeneCards Summary for GABARAP Gene

GABARAP (GABA(A) Receptor-Associated Protein) is a Protein Coding gene. Diseases associated with GABARAP include stiff-person syndrome. Among its related pathways are FoxO signaling pathway and Circadian entrainment. GO annotations related to this gene include microtubule binding and GABA receptor binding. An important paralog of this gene is MAP1LC3C.

UniProtKB/Swiss-Prot for GABARAP Gene

  • Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Gene Wiki entry for GABARAP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GABARAP Gene

Genomics for GABARAP Gene

Genomic Location for GABARAP Gene

Start:
7,240,014 bp from pter
End:
7,242,770 bp from pter
Size:
2,757 bases
Orientation:
Minus strand

Genomic View for GABARAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GABARAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GABARAP Gene

Proteins for GABARAP Gene

  • Protein details for GABARAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95166-GBRAP_HUMAN
    Recommended name:
    Gamma-aminobutyric acid receptor-associated protein
    Protein Accession:
    O95166
    Secondary Accessions:

    Protein attributes for GABARAP Gene

    Size:
    117 amino acids
    Molecular mass:
    13918 Da
    Quaternary structure:
    • Interacts with GPHN and NSF (By similarity). Interacts with ATG3, ATG7, ATG13, RB1CC1, GABRG2, beta-tubulin and ULK1. Interacts with CALR. Interacts with DDX47. Interacts with TP53INP1 and TP53INP2. Interacts with TBC1D25. Directly interacts with SQSTM1. Interacts with MAPK15. Interacts with TECPR2 and PCM1. Interacts with TBC1D5 (PubMed:22354992).

    Three dimensional structures from OCA and Proteopedia for GABARAP Gene

neXtProt entry for GABARAP Gene

Proteomics data for GABARAP Gene at MOPED

Post-translational modifications for GABARAP Gene

  • The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAP-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAP-II.
  • Ubiquitination at Lys24
  • Modification sites at PhosphoSitePlus

Other Protein References for GABARAP Gene

No data available for DME Specific Peptides for GABARAP Gene

Domains for GABARAP Gene

Protein Domains for GABARAP Gene

Suggested Antigen Peptide Sequences for GABARAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95166

UniProtKB/Swiss-Prot:

GBRAP_HUMAN :
  • O95166
Family:
  • Belongs to the ATG8 family.
genes like me logo Genes that share domains with GABARAP: view

No data available for Gene Families for GABARAP Gene

Function for GABARAP Gene

Molecular function for GABARAP Gene

GENATLAS Biochemistry: GABA (A) receptor-associated protein binding GABA-A receptors,gamma 2 subunit and linking the receptors to the cytoskeleton,highly homolog to microtubule associated proteins 1A and 1B ganglioside expression factor homolog 2
UniProtKB/Swiss-Prot Function: Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Gene Ontology (GO) - Molecular Function for GABARAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11096062
GO:0008017 microtubule binding IBA --
GO:0048487 beta-tubulin binding IDA 9892355
GO:0050811 GABA receptor binding IPI 9892355
genes like me logo Genes that share ontologies with GABARAP: view

Phenotypes for GABARAP Gene

MGI mutant phenotypes for GABARAP:
inferred from 2 alleles
genes like me logo Genes that share phenotypes with GABARAP: view

miRNA for GABARAP Gene

miRTarBase miRNAs that target GABARAP

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GABARAP Gene

Localization for GABARAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for GABARAP Gene

Endomembrane system. Cytoplasm, cytoskeleton. Golgi apparatus membrane. Cytoplasmic vesicle, autophagosome. Note=Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae. Colocalizes with microtubules (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GABARAP Gene COMPARTMENTS Subcellular localization image for GABARAP gene
Compartment Confidence
vacuole 5
plasma membrane 4
cytoskeleton 3
cytosol 3
endoplasmic reticulum 2
golgi apparatus 2
lysosome 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for GABARAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0000407 pre-autophagosomal structure IBA --
GO:0000421 autophagic vacuole membrane IDA 15169837
GO:0005737 cytoplasm --
GO:0005764 lysosome IEA --
genes like me logo Genes that share ontologies with GABARAP: view

Pathways for GABARAP Gene

genes like me logo Genes that share pathways with GABARAP: view

Pathways by source for GABARAP Gene

1 BioSystems pathway for GABARAP Gene

Gene Ontology (GO) - Biological Process for GABARAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly IBA --
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0000422 mitochondrion degradation IBA --
GO:0006605 protein targeting TAS 9892355
GO:0006914 autophagy --
genes like me logo Genes that share ontologies with GABARAP: view

Compounds for GABARAP Gene

(1) HMDB Compounds for GABARAP Gene

Compound Synonyms Cas Number PubMed IDs
Gamma-Aminobutyric acid
  • 3-Carboxypropylamine
56-12-2

(3) Novoseek inferred chemical compound relationships for GABARAP Gene

Compound -log(P) Hits PubMed IDs
gaba 70.2 27
n-ethylmaleimide 42.6 3
diazepam 38.4 3
genes like me logo Genes that share compounds with GABARAP: view

Transcripts for GABARAP Gene

Unigene Clusters for GABARAP Gene

GABA(A) receptor-associated protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GABARAP Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for GABARAP Gene

GeneLoc Exon Structure for
GABARAP
ECgene alternative splicing isoforms for
GABARAP

Expression for GABARAP Gene

mRNA expression in normal human tissues for GABARAP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GABARAP Gene

SOURCE GeneReport for Unigene cluster for GABARAP Gene Hs.647421

mRNA Expression by UniProt/SwissProt for GABARAP Gene

O95166-GBRAP_HUMAN
Tissue specificity: Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expressions with GABARAP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GABARAP Gene

Orthologs for GABARAP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GABARAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GABARAP 35
  • 99.72 (n)
  • 100 (a)
GABARAP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GABARAP 35
  • 95.44 (n)
  • 100 (a)
GABARAP 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GABARAP 35
  • 96.01 (n)
  • 100 (a)
GABARAP 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gabarap 35
  • 95.44 (n)
  • 100 (a)
Gabarap 16
Gabarap 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Gabarap 35
  • 95.44 (n)
  • 100 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 31 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii GABARAP (2 of 2) 36
  • 97 (a)
OneToMany
gabarapa 35
  • 81.9 (n)
  • 98.28 (a)
gabarapa 36
  • 93 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Atg8a 36
  • 88 (a)
OneToMany
Atg8b 36
  • 75 (a)
OneToMany
CG12334 37
  • 77 (a)
worm
(Caenorhabditis elegans)
Secernentea lgg-1 36
  • 79 (a)
OneToOne
lgg-1 37
  • 83 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG8 36
  • 55 (a)
OneToMany
Species with no ortholog for GABARAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GABARAP Gene

ENSEMBL:
Gene Tree for GABARAP (if available)
TreeFam:
Gene Tree for GABARAP (if available)

Paralogs for GABARAP Gene

Paralogs for GABARAP Gene

Pseudogenes.org Pseudogenes for GABARAP Gene

genes like me logo Genes that share paralogs with GABARAP: view

Variants for GABARAP Gene

Sequence variations from dbSNP and Humsavar for GABARAP Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs222843 -- 7,242,662(-) TTTAG(A/G)GTAAT upstream-variant-2KB
rs374487 -- 7,242,504(+) CCCCG(A/C)TAAGA upstream-variant-2KB
rs3214155 -- 7,241,912(+) TCTTA(-/ATCA)GACGG intron-variant
rs7216047 -- 7,241,962(+) GCAAC(C/G)TTAGC intron-variant
rs8192511 -- 7,241,733(-) GACAG(A/G)TGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GABARAP Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
esv2665200 CNV Deletion 23128226
dgv3053n71 CNV Loss 21882294
nsv907637 CNV Loss 21882294

Relevant External Links for GABARAP Gene

HapMap Linkage Disequilibrium report
GABARAP
Human Gene Mutation Database (HGMD)
GABARAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GABARAP Gene

Disorders for GABARAP Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for GABARAP Gene including...

Search for GABARAP Gene in MalaCards »

(4) University of Copenhagen DISEASES for GABARAP Gene

(1) Novoseek inferred disease relationships for GABARAP Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for GABARAP

Genetic Association Database (GAD)
GABARAP
Human Genome Epidemiology (HuGE) Navigator
GABARAP
genes like me logo Genes that share disorders with GABARAP: view

No data available for UniProtKB/Swiss-Prot for GABARAP Gene

Publications for GABARAP Gene

  1. GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton. (PMID: 9892355) Wang H. … Olsen R.W. (Nature 1999) 2 3 4 23
  2. The human homolog of Saccharomyces cerevisiae Apg7p is a Protein- activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3. (PMID: 11096062) Tanida I. … Kominami E. (J. Biol. Chem. 2001) 3 4 23
  3. Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p. (PMID: 11825910) Tanida I. … Kominami E. (J. Biol. Chem. 2002) 3 4 23
  4. Solution structure of human GABA(A) receptor-associated protein GABARAP: implications for biological function and its regulation. (PMID: 11875056) Stangler T. … Willbold D. (J. Biol. Chem. 2002) 3 4 23
  5. 1H, 13C and '5N resonance assignments of GABARAP, GABAA receptor associated protein. (PMID: 11885988) Kouno T. … Kawano K. (J. Biomol. NMR 2002) 3 4 23

Products for GABARAP Gene

Sources for GABARAP Gene

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