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Aliases & Descriptions for GABARAP
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLC3B 3 | | FLJ25768 2 | | MGC120154 2 | | MGC120155 2 | | MM46 1, 2, 3 |
| | | Descriptions |
|---|
| GABA(A) receptor-associated protein 2, 3 |
|
| | Search outside databases for aliases for GABARAP genePrevious GC identifers: GC16M055704 GC17M007873 GC17M007086 GC17M007344 |
Summaries for GABARAP(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for GABARAP: Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq] UniProtKB/Swiss-Prot: GBRAP_HUMAN, O95166Function: May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton (By similarity)Gene Wiki entry for GABARAP |
Genomic Location for GABARAP
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the GABARAP gene 
Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC chromosome: 17GABARAP Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M007084:
(about GC identifiers)
Start:
|
7,084,462 bp from pter |
End:
|
7,086,477 bp from pter |
Size:
|
2,016 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000017.9 NT_010718.15
| Proteins for GABARAP
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: GBRAP_HUMAN, O95166 (See
protein sequence)Recommended Name: Gamma-aminobutyric acid receptor-associated protein Size: 117 amino acids; 13918 Da
Subunit: Interacts with GPHN and NSF (By similarity). Interacts with GABRG2, beta-tubulin and ULK1
Subcellular location: Endomembrane system (By similarity). Cytoplasm, cytoskeleton (By similarity). Golgi apparatus membrane (By similarity). Note=Largely associated with intracellular membrane structures including the Golgi apparatus and post-synaptic cisternae. Colocalizes with microtubules (By similarity)
PDB structures from and Proteopedia :1GNU (3D)
 1KLV (3D)
 1KM7 (3D)
 1KOT (3D)
 3D32 (3D)
 3DOW (3D)
 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_009209.1
ENSEMBL proteins: ENSP00000306866
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5/10 Gene Ontology (GO) cellular component terms (links to tree view) (see all 10
): About this table
Antibodies for GABARAP: Assays for GABARAP: | Protein
Domains/ Families for GABARAP(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O95166
ProtoNet protein and cluster: O95166 1 Blocks protein family: IPB004241 Light chain 3 (LC3)
UniProtKB/Swiss-Prot: GBRAP_HUMAN, O95166Similarity: Belongs to the MAP1 LC3 family | Gene Function for GABARAP
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007278
Applied Biosystems Silencer® siRNAs for GABARAP
Sigma-Aldrich siRNA and siRNA Panels for GABARAP  Sigma-Aldrich shRNA Panels and shRNA for GABARAP  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_007278                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_007278                                  untagged cDNA clone in CMV expression vector: NM_007278 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_007278
UniProtKB/Swiss-Prot: GBRAP_HUMAN, O95166Function: May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton (By similarity)Genatlas biochemistry entry for GABARAP:GABA (A) receptor-associated protein binding GABA-A receptors,gamma 2 subunit and linking the receptors to the cytoskeleton,highly homolog to microtubule associated proteins 1A and 1B ganglioside expression factor homolog 21 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Gabarap):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for GABARAP
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for GABARAP (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for GABARAP 
5/35 Interacting proteins for GABARAP (O951661, 2 ENSP000003068663) via UniProtKB, MINT, and/or STRING (see all 35
)About this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for GABARAP(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for GABARAP
|
Transcripts for GABARAP(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007278
Sigma-Aldrich siRNA and siRNA Panels for GABARAP  Sigma-Aldrich shRNA Panels and shRNA for GABARAP  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_007278 REFSEQ mRNAs for GABARAP gene: NM_007278.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_007278               OriGene GFP tagged cDNA clone in CMV expression vector: NM_007278                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_007278                                  untagged cDNA clone in CMV expression vector: NM_007278  Additional cDNA sequence: AB030711.1 AF044671.1 AF067171.1 AF161586.1 AF183425.1 AK098634.1 AK312205.1 AL050182.1 BC106748.1 BC106749.1 CR457043.1 CR542235.1 CR592433.1 CR597728.1 CR624246.1 24/28 DOTS entries (see all 28
): DT.99926443 DT.91773251 DT.100649015 DT.449606 DT.101985433 DT.120968722 DT.120968637 DT.91773230 DT.99937435 DT.120968554 DT.120968747 DT.120968788 DT.75111082 DT.100848809 DT.95271157 DT.120968638 DT.120968758 DT.95271171 DT.450749 DT.95127999 DT.95271155 DT.100848801 DT.120968719 DT.91773237 24/672 AceView cDNA sequences (see all 672
):F15724 BU149629 BU631380 BU856629 AA427910 T31891 BQ962375 CB269137 AA719757 BU149493 BM838407 CR607499 BQ643517 BM980136 CF129367 BU677714 AI474511 AW152092 AI219019 AA862576 AI929800 AW273245 BM450012 CR592433
highest scoring ESTs for GABARAP:AF044671 CB067200 H87141 R78846 AA040772 AA135648 AA296984 AA297054 AA297636 AA297957 Unigene Cluster for GABARAP: GABA(A) receptor-associated protein Hs.647421 [show with all ESTs]Unigene Representative Sequence: BM803698
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for GABARAP
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | |
| SP1: | |   | |   | - |   | |   | |   | - |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | - |   | |   | - |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | - |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for GABARAP
1 Ensembl transcript including schematic representation: ENST00000302386
|
Expression for GABARAP
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| GABARAP expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for GABARAP
1 / 2 / 3 3 probe-sets matching GABARAP gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AAGAAGACTT
SOURCE GeneReport for Unigene cluster: Hs.647421
Expression variation in blood from EXPOLDB for GABARAP UniProtKB/Swiss-Prot: GBRAP_HUMAN, O95166Tissue specificity: Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas |
Orthologs for GABARAP
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GABARAP gene from 5/16 species (see all 16
)
About this table Species with no ortholog for GABARAP
ENSEMBL Gene Tree for GABARAP | Paralogs for GABARAP(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for GABARAP gene
- GABARAPL32
|
SNPs/Variants for GABARAP(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for GABARAP (up to first 250kb)
|
Disorders & Mutations for GABARAP
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605125
Human Genome Epidemiology Navigator: GABARAP (1 document)
|
Medical News for GABARAP(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for GABARAP (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/72 PubMed articles for GABARAP gene (see all 72
):- GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton. (PubMed id 9892355)1, 2, 3, 4 Wang H.... Olsen R.W. (1999)
- The X-ray crystal structure and putative ligand-derived peptide binding properties of gamma-aminobutyric acid receptor type A receptor-associated protein. (PubMed id 11729197)1, 3, 4 Knight D.... Keep N.H. (2002)
- Solution structure of human GABA(A) receptor-associated protein GABARAP: implications for biolgoical funcrion and its regulation. (PubMed id 11875056)1, 3, 4 Stangler T.... Willbold D. (2002)
- 1H, 13C and '5N resonance assignments of GABARAP, GABAA receptor associated protein. (PubMed id 11885988)1, 3, 4 Kouno T.... Kawano K. (2002)
- Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)3, 4 Hu R.-M.... Chen J.-L. (2000)
- Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation. (PubMed id 11146101)3, 4 Okazaki N.... Muramatsu M.-A. (2000)
- Binding of the GABA(A) receptor-associated protein (GABARAP) to microtubules and microfilaments suggests involvement of the cytoskeleton in GABARAPGABA(A) receptor interaction. (PubMed id 10899939)1, 3 Wang H. and Olsen R.W. (2000)
- Sustained structural change of GABA(A) receptor-associated protein underlies long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron. (PubMed id 17581966)1, 3 Kawaguchi S.Y. and Hirano T. (2007)
- Biochemical identification of the binding domain in the GABA(A) receptor-associated protein (GABARAP) mediating dimer formation. (PubMed id 12367594)1, 3 Nymann-Andersen J....Olsen R.W. (2002)
- Association of human transferrin receptor with GABARAP. (PubMed id 11997026)1, 3 Green F....Enns C.A. (2002)
|
Search for GABARAP
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing GABARAP
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing GABARAP
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GABARAP(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for GABARAP(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for GABARAP:

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Incremental update: 13 Oct 2009
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