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Aliases for GAB3 Gene

Aliases for GAB3 Gene

  • GRB2-Associated Binding Protein 3 2 3
  • Growth Factor Receptor Bound Protein 2-Associated Protein 3 4
  • Gab3 Scaffolding Protein 2
  • GRB2-Associated Binder 3 4
  • DOS/Gab Family Member 3 2

External Ids for GAB3 Gene

Previous GeneCards Identifiers for GAB3 Gene

  • GC0XM147966
  • GC0XM150284
  • GC0XM151488
  • GC0XM152371
  • GC0XM153467
  • GC0XM153556
  • GC0XM153903
  • GC0XM142447

Summaries for GAB3 Gene

Entrez Gene Summary for GAB3 Gene

  • This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for GAB3 Gene

GAB3 (GRB2-Associated Binding Protein 3) is a Protein Coding gene. Among its related pathways are p70S6K Signaling and Akt Signaling Pathway. An important paralog of this gene is GAB2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAB3 Gene

Genomics for GAB3 Gene

Regulatory Elements for GAB3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GAB3 Gene

Chromosome:
X
Start:
154,675,249 bp from pter
End:
154,751,583 bp from pter
Size:
76,335 bases
Orientation:
Minus strand

Genomic View for GAB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GAB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAB3 Gene

Proteins for GAB3 Gene

  • Protein details for GAB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWW8-GAB3_HUMAN
    Recommended name:
    GRB2-associated-binding protein 3
    Protein Accession:
    Q8WWW8
    Secondary Accessions:
    • A6NHF8
    • E9PB44

    Protein attributes for GAB3 Gene

    Size:
    586 amino acids
    Molecular mass:
    65589 Da
    Quaternary structure:
    • Interacts with PIK3R/p85, SHP2 and GRAP2/MONA (By similarity). May interact with Grb2.
    SequenceCaution:
    • Sequence=AK307927; Type=Erroneous termination; Positions=587; Note=Translated as stop.; Evidence={ECO:0000305};

    Alternative splice isoforms for GAB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAB3 Gene

Proteomics data for GAB3 Gene at MOPED

Post-translational modifications for GAB3 Gene

  • Phosphorylated on tyrosine residue(s) after macrophage colony-stimulating factor (M-CSF) receptor stimulation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAB3 Gene

Antibody Products

No data available for DME Specific Peptides for GAB3 Gene

Domains & Families for GAB3 Gene

Gene Families for GAB3 Gene

Protein Domains for GAB3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8WWW8

UniProtKB/Swiss-Prot:

GAB3_HUMAN :
  • Contains 1 PH domain.
  • Belongs to the GAB family.
Domain:
  • Contains 1 PH domain.
Family:
  • Belongs to the GAB family.
genes like me logo Genes that share domains with GAB3: view

Function for GAB3 Gene

Gene Ontology (GO) - Molecular Function for GAB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with GAB3: view
genes like me logo Genes that share phenotypes with GAB3: view

Animal Model Products

miRNA for GAB3 Gene

miRTarBase miRNAs that target GAB3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GAB3 Gene

Localization for GAB3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAB3 Gene COMPARTMENTS Subcellular localization image for GAB3 gene
Compartment Confidence
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GAB3 Gene

Pathways & Interactions for GAB3 Gene

genes like me logo Genes that share pathways with GAB3: view

Pathways by source for GAB3 Gene

1 Qiagen pathway for GAB3 Gene
1 R&D Systems pathway for GAB3 Gene

Gene Ontology (GO) - Biological Process for GAB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030225 macrophage differentiation IEA --
genes like me logo Genes that share ontologies with GAB3: view

No data available for SIGNOR curated interactions for GAB3 Gene

Drugs & Compounds for GAB3 Gene

No Compound Related Data Available

Transcripts for GAB3 Gene

Unigene Clusters for GAB3 Gene

GRB2-associated binding protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GAB3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: -
SP3: -
SP4: - -

Relevant External Links for GAB3 Gene

GeneLoc Exon Structure for
GAB3
ECgene alternative splicing isoforms for
GAB3

Expression for GAB3 Gene

mRNA expression in normal human tissues for GAB3 Gene

mRNA differential expression in normal tissues according to GTEx for GAB3 Gene

This gene is overexpressed in Whole Blood (x8.4) and Spleen (x4.7).

Protein differential expression in normal tissues from HIPED for GAB3 Gene

This gene is overexpressed in Platelet (56.2) and CD8 Tcells (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GAB3 Gene



SOURCE GeneReport for Unigene cluster for GAB3 Gene Hs.496982

genes like me logo Genes that share expression patterns with GAB3: view

Protein tissue co-expression partners for GAB3 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GAB3 Gene

Orthologs for GAB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GAB3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GAB3 35
  • 82.59 (n)
  • 79.9 (a)
GAB3 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gab3 35
  • 82.76 (n)
  • 78.35 (a)
Gab3 16
Gab3 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GAB3 35
  • 99.77 (n)
  • 99.83 (a)
GAB3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GAB3 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GAB3 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GAB3 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves GAB3 35
  • 70.4 (n)
  • 69.54 (a)
GAB3 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GAB3 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gab3 35
  • 65.01 (n)
  • 61.77 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-92i20.1 35
  • 53.06 (n)
  • 49.17 (a)
GAB3 (1 of 2) 36
  • 37 (a)
OneToMany
GAB3 (2 of 2) 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta dos 36
  • 13 (a)
OneToMany
Species with no ortholog for GAB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAB3 Gene

ENSEMBL:
Gene Tree for GAB3 (if available)
TreeFam:
Gene Tree for GAB3 (if available)

Paralogs for GAB3 Gene

Paralogs for GAB3 Gene

(4) SIMAP similar genes for GAB3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GAB3: view

Variants for GAB3 Gene

Sequence variations from dbSNP and Humsavar for GAB3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs884840 -- 154,699,756(-) TTAAA(A/G)CATTT intron-variant
rs1509788 -- 154,718,608(+) CAAGT(C/T)TTGCT intron-variant
rs1509789 -- 154,725,067(-) CTTTT(C/T)ACGAT intron-variant
rs1567406 -- 154,710,057(-) TTATT(A/G)CAATC intron-variant
rs1605895 -- 154,721,518(-) GGTTT(A/C)TGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAB3 Gene

Variant ID Type Subtype PubMed ID
esv33784 CNV Gain+Loss 17666407
nsv518228 CNV Gain 19592680
nsv521523 CNV Gain 19592680

Variation tolerance for GAB3 Gene

Residual Variation Intolerance Score: 38.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GAB3 Gene

HapMap Linkage Disequilibrium report
GAB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAB3 Gene

Disorders for GAB3 Gene

Relevant External Links for GAB3

Genetic Association Database (GAD)
GAB3
Human Genome Epidemiology (HuGE) Navigator
GAB3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAB3
genes like me logo Genes that share disorders with GAB3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAB3 Gene

Publications for GAB3 Gene

  1. Gab3, a new DOS/Gab family member, facilitates macrophage differentiation. (PMID: 11739737) Wolf I. … Rohrschneider L.R. (Mol. Cell. Biol. 2002) 2 67
  2. Gab docking proteins in cardiovascular disease, cancer, and inflammation. (PMID: 23431498) Nakaoka Y. … Komuro I. (Int J Inflam 2013) 67
  3. Grb2-associated binding (Gab) proteins in hematopoietic and immune cell biology. (PMID: 22163099) Vaughan T.Y. … Bunting K.D. (Am J Blood Res 2011) 67
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 67
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 67

Products for GAB3 Gene

Sources for GAB3 Gene

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