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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GAB1 Gene

protein-coding   GIFtS: 63
GCID: GC04P144257

GRB2-associated binding protein 1
 Explore 21 diseases affiliated with
GAB1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GAB1    

Aliases
for GAB1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
GRB2-Associated Binding Protein 11 2
Growth Factor Receptor Bound Protein 2-Associated Protein 12 3
GRB2-Associated Binder 12 3
GRB2-Associated-Binding Protein 12

External Ids:    HGNC: 40661   Entrez Gene: 25492   Ensembl: ENSG000001094587   OMIM: 6044395   UniProtKB: Q134803   

Export aliases for GAB1 gene to outside databases

Previous GC identifers: GC04P145054 GC04P144619 GC04P144724 GC04P144835 GC04P144615 GC04P144477 GC04P139987


Summaries
for GAB1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GAB1:
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important
mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and
apoptosis. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Aug
2008)

UniProtKB/Swiss-Prot: GAB1_HUMAN, Q13480
Function: Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type
kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor
(EGFR) and the insulin receptor (INSR)

Gene Wiki entry for GAB1


Genomic Views
for GAB1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GAB1 gene promoter:
         AP-1   ATF-2   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GAB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GAB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.21   Ensembl cytogenetic band:  4q31.21   HGNC cytogenetic band: 4q31.1

GAB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GAB1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P144257:  view genomic region     (about GC identifiers)

Start:
 144,257,915 bp from pter      End:
 144,395,721 bp from pter
Size:
 137,807 bases      Orientation:
 plus strand

Proteins
for GAB1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GAB1_HUMAN, Q13480 (See protein sequence)
Recommended Name: GRB2-associated-binding protein 1  
Size: 694 amino acids; 76616 Da
Subunit: Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2. Interacts with
PTPRJ. Identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1. Interacts (phosphorylated) with PTPN11.
Interacts with HCK
Secondary accessions: A8K152 Q4W5G2 Q6P1W2
Alternative splicing: 2 isoforms:  Q13480-1   Q13480-2   (Contains a phosphoserine at position 547)

Explore the universe of human proteins at neXtProt for GAB1: NX_Q13480

Post-translational modifications:

  • Phosphorylated in response to FGFR1 activation. Phosphorylated on tyrosine residue(s) by the epidermal growth factor
    • receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several
    proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13480

    • GAB1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_002030.2  NP_997006.1  

    ENSEMBL proteins: 
     ENSP00000262995   ENSP00000262994   ENSP00000427435   ENSP00000426668   ENSP00000424554  
     ENSP00000425921   ENSP00000420867   ENSP00000426297  
    Reactome Protein details: Q13480
    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 2): GAB1
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    Novus Biologicals GAB1 Proteins
    Novus Biologicals GAB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for GAB1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--


    GAB1 for ontologies           About GeneDecksing



    GAB1 Antibody Products: 
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    Assay Products for GAB1: 
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for GAB1

    Protein Domains /
    Families
    for GAB1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GAB1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q13480

    ProtoNet protein and cluster: Q13480

    1 Blocks protein family: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: GAB1_HUMAN, Q13480
    Similarity: Belongs to the GAB family
    Similarity: Contains 1 PH domain


    Function
    for GAB1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GAB1_HUMAN, Q13480
    Function: Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type
    kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor
    (EGFR) and the insulin receptor (INSR)

    miRNA
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    8/112 QIAGEN miScript miRNA Assays for microRNAs that regulate GAB1 (see all 112):
    hsa-miR-361-5p hsa-miR-3152-3p hsa-miR-376b hsa-miR-1224-3p hsa-miR-106a hsa-miR-128 hsa-miR-1260b hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmid: GAB1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: GAB1
    OriGene siRNA: GAB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GAB1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for GAB1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GAB1 (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): GAB1 (NM_207123)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GAB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAB1 

    Cell Line
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    Search LifeMap BioReagents cell lines for GAB1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAB1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IEA--
    GO:0005070SH3/SH2 adaptor activity TAS8596638
    GO:0005515protein binding IPI9658397
    GO:0005543phospholipid binding IEA--


    GAB1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for GAB1:
     Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Gab1tm1Ajw for GAB1
         13 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Gab1):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  growth/size  homeostasis/metabolism  integument  liver/biliary system 
     mortality/aging  muscle  vision/eye 

    GAB1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GAB1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/45 super-pathways (see all 45) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    2Development HGF signaling pathway
    8/11 pathways (see all 11)
    		Development HGF signaling pathway1.00
    		Development_EGFR signaling via PIP30.26
    		Development_HGF signaling pathway0.78
    		Apoptosis and survival_NGF signaling pathway0.25
    		Development_Neurotrophin family signaling0.45
    		Apoptosis and survival NGF signaling pathway0.25
    		Development Neurotrophin family signaling0.45
    		Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)0.23
    3PIP3 activates AKT signaling
    8/10 pathways (see all 10)
    		PI-3K cascade1.00
    		PI3K/AKT activation0.97
    		PIP3 activates AKT signaling1.00
    		GAB1 signalosome0.96
    		PI3K/AKT Signaling in Cancer1.00
    		Constitutive PI3K/AKT Signaling in Cancer0.88
    		PI3K events in ERBB2 signaling1.00
    		Signaling by SCF-KIT0.72
    4IRS-related events
    		IRS-related events1.00
    		Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.90
    		IRS-mediated signalling0.98
    		IGF1R signaling cascade0.90
    		Insulin receptor signalling cascade0.94
    		PI3K Cascade0.84
    		IRS-related events triggered by IGF1R0.93
    		Signaling by Insulin receptor0.74
    5Development FGFR signaling pathway
    		Development FGFR signaling pathway1.00
    		Development_Flt3 signaling0.45
    		Development_FGFR signaling pathway0.98
    		Development Flt3 signaling0.45

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/10 EMD Millipore Pathways for GAB1 (see all 10)
        Development HGF signaling pathway
    Apoptosis and survival NGF signaling pathway
    Cell adhesion PLAU signaling
    Development FGF-family signaling
    Development FGFR signaling pathway

    5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GAB1 (see all 11)
        HGF Pathway
    Internalin Pathway
    Molecular Mechanisms of Cancer
    GDNF-Family Ligands and Receptor Interactions
    TRKA Signaling

    1 Cell Signaling Technology (CST) Pathway for GAB1
        Tyrosine Kinases / Adaptors

    5/10 GeneGo (Thomson Reuters) Pathways for GAB1 (see all 10)
        Development FGF-family signaling
    Development Neurotrophin family signaling
    Signal transduction AKT signaling
    Translation Regulation of EIF2 activity
    Cell adhesion PLAU signaling

    5/23 BioSystems Pathways for GAB1 (see all 23) 
        EGFR1 Signaling Pathway
    ErbB signaling pathway
    Signaling Pathways in Glioblastoma
    Insulin Signaling
    IL-6 Signaling Pathway

    5/39        Reactome Pathways for GAB1 (see all 39)
        Signaling by EGFR in Cancer
    Downstream signal transduction
    IRS-mediated signalling
    Signal Transduction
    Signaling by PDGF


    4         Kegg Pathways  (Kegg details for GAB1):
        ErbB signaling pathway
    Neurotrophin signaling pathway
    Bacterial invasion of epithelial cells
    Renal cell carcinoma


    GAB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GAB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/58 Interacting proteins for GAB1 (Q134801, 2, 3 ENSP000002629954) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN11Q061241, 2, 3, ENSP000003409444EBI-517684,EBI-297779 MINT-6169355 MINT-6169300 MINT-6169451 MINT-6169344 MINT-8025571 MINT-8029574 MINT-6169406 MINT-6169374 MINT-8029606 MINT-8288652 MINT-8025555 MINT-7026140 MINT-6169338 MINT-6169389 MINT-6169309 MINT-6169327 MINT-6169291 MINT-8029590 I2D: score=10 STRING: ENSP00000340944
    PIK3R1P279862, 3, ENSP000002743354MINT-8028258 MINT-1893011 MINT-8035009 MINT-8030430 MINT-8030445 MINT-8034994 MINT-8028243 I2D: score=6 STRING: ENSP00000274335
    METP085812, 3, ENSP000003172724MINT-58404 I2D: score=4 STRING: ENSP00000317272
    PTPRJQ129132, 3, ENSP000004000104MINT-7026908 I2D: score=2 STRING: ENSP00000400010
    RASA1P209362, 3, ENSP000002743764MINT-8035797 I2D: score=1 STRING: ENSP00000274376
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity ----
    GO:0006979response to oxidative stress IEA--
    GO:0007165signal transduction ----
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007257activation of JUN kinase activity IEA--


    GAB1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GAB1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GAB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GAB1
    10/16 Novoseek chemical compound relationships for GAB1 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 80.7 46 10022866 (3), 9632795 (2), 19050043 (2), 15351743 (2) (see all 29)
    tyrosine 77.4 165 11695994 (8), 11262408 (7), 10194437 (6), 8906793 (5) (see all 62)
    ly294002 62.2 4 19665053 (2), 10022866 (1), 11695994 (1)
    phosphatidylinositol-3,4,5-trisphosphate 61.1 4 10531383 (2), 10194437 (1), 12686619 (1)
    phosphoinositide 56.9 6 11695994 (2), 15784547 (1), 11134009 (1), 15679846 (1)
    phosphotyrosine 55.5 8 10194437 (1), 11323411 (1), 8906793 (1), 12582165 (1) (see all 6)
    wortmannin 54.8 2 10842168 (1)
    gp 130 47.9 7 9632795 (2), 10068651 (2), 11196191 (1), 12855672 (1)
    phenylalanine 29 6 11002419 (1), 15784547 (1), 11403719 (1), 12446613 (1)
    threonine 14.4 13 15379552 (4), 11313945 (2), 17625596 (2), 12748184 (1)

    Search CenterWatch for drugs/clinical trials and news about GAB1 

    Transcripts
    for GAB1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GAB1 gene (2 alternative transcripts): 
    NM_002039.3  NM_207123.2  

    Unigene Clusters for GAB1:

    GRB2-associated binding protein 1
    Hs.80720  [show with all ESTs], Hs.618456
    Unigene Representative Sequences: NM_207123, AK074381
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262995(uc003ijd.3 uc003ije.3 uc011chq.2) ENST00000262994
    ENST00000514639 ENST00000515366 ENST00000505913 ENST00000515388 ENST00000509992
    ENST00000511836 ENST00000512843 ENST00000507334 ENST00000507070 ENST00000510615
    ENST00000508833 ENST00000511109

    miRNA
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    8/112 QIAGEN miScript miRNA Assays for microRNAs that regulate GAB1 (see all 112):
    hsa-miR-361-5p hsa-miR-3152-3p hsa-miR-376b hsa-miR-1224-3p hsa-miR-106a hsa-miR-128 hsa-miR-1260b hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmid: GAB1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GAB1 (see all 7)
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    Clone
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    Primer
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    Additional cDNA sequence: AK074381.1 

    10 DOTS entries:

    DT.409922  DT.97819196  DT.95367162  DT.97793558  DT.121221662  DT.91925642  DT.91842447  DT.121221692 
    DT.97844118  DT.100641098 

    2 AceView cDNA sequences:

    AK074381 AA969091 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GAB1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:              -     -     -                                                                     
    SP2:              -     -     -                                   -                                 
    SP3:                                                                                                


    ECgene alternative splicing isoforms for GAB1

    Expression
    for GAB1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GAB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CATTACTACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GAB1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeHypobranchial MusclesMuscle Progenitor CellsSkeletal Muscle
    LimbForelimb MyotomeLimb Muscle Progenitor CellsSkeletal Muscle
    LimbHindlimb MyotomeLimb Muscle Progenitor CellsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See GAB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GAB1

    SOURCE GeneReport for Unigene clusters: Hs.80720 Hs.618456
        SABiosciences Expression via Pathway-Focused PCR Arrays including GAB1: 
              Insulin Signaling Pathway in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat

    Primer
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    Orthologs
    for GAB1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for GAB1 gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Gab11 , 5 growth factor receptor bound protein 2-associated protein more1, 5 84.39(n)1
    90.35(a)1    		   8 (38.47 cM)5
    143881  NM_021356.21  NP_067331.21 
     807644345 
    chicken
    (Gallus gallus)    		 Aves GAB11 GRB2-associated binding protein 1 82.61(n)
    88.55(a)    		   422456  XM_001232601.2  XP_001232602.1 
    lizard
    (Anolis carolinensis)    		 Reptilia GAB16
    		 --
    		 80(a)
    		 1 ↔ 1
    		 5(118554243-118574718)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.75332 Xenopus laevis transcribed sequence with weak similarity more 82.19(n)    CA985958.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.175092 Danio rerio mRNA similar to growth factor receptor more 76.04(n)    BC049429.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta dos6
    		 daughter of sevenless
    		 13(a)
    		 1 → many
    		 3L(2589414-2595590)


    ENSEMBL Gene Tree for GAB1 (if available)
    TreeFam Gene Tree for GAB1 (if available) 

    Paralogs
    for GAB1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GAB1 gene
    GAB32  GAB22  GAB42  
    2 SIMAP similar genes for GAB1 using alignment to 7 protein entries:     GAB1_HUMAN (see all proteins):
    GAB2    GAB4

    GAB1 for paralogs           About GeneDecksing



    Genomic Variants
    for GAB1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for GAB1
         4 CNVs: 98907 3519 1689 92436
    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for GAB1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GAB1 for disorders           About GeneDecksing

    OMIM gene information: 604439    OMIM disorders: --

    20/21 diseases for GAB1 (see all 21):    About MalaCards
    atrophic gastritis    leopard syndrome    synovial sarcoma    papillary thyroid carcinoma
    noonan syndrome    insulin resistance    gastritis    renal cell carcinoma
    squamous cell carcinoma    multiple myeloma    thyroid carcinoma    sarcoma
    hepatitis b    breast cancer    myeloma    glioblastoma
    carcinoma    thyroiditis    colorectal cancer    hepatitis

    7 Novoseek disease relationships for GAB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma 17.1 3 14701753 (2), 9890893 (1)
    sarcoma 4.55 1 17210721 (1)
    breast cancer 4.07 2 16715136 (1), 12748184 (1)
    breast carcinoma 0 1 15952937 (1)
    necrosis 0 1 17284447 (1)
    tumors 0 6 18192688 (2), 14668796 (1), 9890893 (1), 12748184 (1) (see all 5)
    cancer 0 2 17211494 (1), 19350053 (1)

    Human Genome Epidemiology (HuGE) Navigator: GAB1 (9 documents)

    Export disorders for GAB1 gene to outside databases

    Publications
    for GAB1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GAB1 gene, integrated from 9 sources (see all 190):
    (articles sorted by number of sources associating them with GAB1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A Grb2-associated docking protein in EGF- and insulin-receptor signalling. (PubMed id 8596638)1, 2, 3, 9 Holgado-Madruga M....Wong A.J. (1996)
    2. Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells. (PubMed id 15010462)1, 2, 9 Podar K....Anderson K.C. (2004)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. (PubMed id 12486104)1, 2 Brdicka T.... Horejsi V. (2002)
    7. Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2. (PubMed id 11323411)1, 9 Cunnick J.M....Wu J. (2001)
    8. A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling. (PubMed id 10648629)1, 9 Rodrigues G.A....Schlessinger J. (2000)
    9. Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor. (PubMed id 15952937)1, 9 Meng S....Wu J. (2005)
    10. The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase. (PubMed id 10022866)1, 9 Maroun C.R....Park M. (1999)

    External Searches for GAB1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GAB1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2549 HGNC: 4066 AceView: GAB1.1 Ensembl:ENSG00000109458 euGenes: HUgn2549
    ECgene: GAB1 Kegg: 2549 H-InvDB: GAB1

    Other Databases showing GAB1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GAB1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GAB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GAB1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/gab1/

    Intellectual Property
    for GAB1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GAB1 gene:
    Search GeneIP for patents involving GAB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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