Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GAB1 Gene

protein-coding   GIFtS: 64
GCID: GC04P144257

GRB2-Associated Binding Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
GRB2-Associated Binding Protein 11 2
Growth Factor Receptor Bound Protein 2-Associated Protein 12 3
GRB2-Associated Binder 12 3
GRB2-Associated-Binding Protein 12

External Ids:    HGNC: 40661   Entrez Gene: 25492   Ensembl: ENSG000001094587   OMIM: 6044395   UniProtKB: Q134803   

Export aliases for GAB1 gene to outside databases

Previous GC identifers: GC04P145054 GC04P144619 GC04P144724 GC04P144835 GC04P144615 GC04P144477 GC04P139987


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GAB1 Gene:
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an
important mediator of branching tubulogenesis and plays a central role in cellular growth response,
transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Aug 2008)

GeneCards Summary for GAB1 Gene: 
GAB1 (GRB2-associated binding protein 1) is a protein-coding gene. Diseases associated with GAB1 include leopard syndrome, and atrophic gastritis, and among its related super-pathways are Development EGFR signaling via small GTPases and ErbB signaling pathway. GO annotations related to this gene include SH3/SH2 adaptor activity and phospholipid binding. An important paralog of this gene is GAB3.

UniProtKB/Swiss-Prot: GAB1_HUMAN, Q13480
Function: Adapter protein that plays a role in intracellular signaling cascades triggered by activated
receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth
factor receptor (EGFR) and the insulin receptor (INSR)

Gene Wiki entry for GAB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GAB1 gene promoter:
         AP-1   ATF-2   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGAB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GAB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.21   Ensembl cytogenetic band:  4q31.21   HGNC cytogenetic band: 4q31.1

GAB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GAB1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P144257:  view genomic region     (about GC identifiers)

Start:
144,257,915 bp from pter      End:
144,395,721 bp from pter
Size:
137,807 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GAB1_HUMAN, Q13480 (See protein sequence)
Recommended Name: GRB2-associated-binding protein 1  
Size: 694 amino acids; 76616 Da
Subunit: Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2. Interacts
with PTPRJ. Identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1. Interacts (phosphorylated) with
PTPN11. Interacts with HCK
Secondary accessions: A8K152 Q4W5G2 Q6P1W2
Alternative splicing: 2 isoforms:  Q13480-1   Q13480-2   (Contains a phosphoserine at position 547)

Explore the universe of human proteins at neXtProt for GAB1: NX_Q13480

Explore proteomics data for GAB1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated in response to FGFR1 activation. Phosphorylated on tyrosine residue(s) by the epidermal growth
    factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction
    with several proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13480

  • GAB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GAB1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_002030.2  NP_997006.1  

    ENSEMBL proteins: 
     ENSP00000262995   ENSP00000262994   ENSP00000427435   ENSP00000426668   ENSP00000424554  
     ENSP00000425921   ENSP00000420867   ENSP00000426297  
    Reactome Protein details: Q13480
    Human Recombinant Protein Products for GAB1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for GAB1
    OriGene Protein Over-expression Lysate for GAB1
    OriGene MassSpec for GAB1 
    OriGene Custom Protein Services for GAB1
    GenScript Custom Purified and Recombinant Proteins Services for GAB1
    Novus Biologicals GAB1 Proteins
    Novus Biologicals GAB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GAB1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    GAB1 for ontologies           About GeneDecksing



    GAB1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of GAB1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for GAB1 
    OriGene Antibodies for GAB1
    OriGene Custom Antibody Services for GAB1
    GenScript Superior Antibodies for GAB1
    Novus Biologicals GAB1 Antibody
    Abcam antibodies for GAB1
    Cloud-Clone Corp. Antibodies for GAB1 
    ThermoFisher Antibody for GAB1
    Search LSBio for Antibodies for GAB1 

    Assay Products for GAB1: 
    EMD Millipore Kits and Assays for the Analysis of GAB1
    OriGene Custom Assay Services for GAB1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GAB1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GAB1 
    Cloud-Clone Corp. CLIAs for GAB1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing

    2 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q13480

    ProtoNet protein and cluster: Q13480

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: GAB1_HUMAN, Q13480
    Similarity: Belongs to the GAB family
    Similarity: Contains 1 PH domain


    GAB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GAB1_HUMAN, Q13480
    Function: Adapter protein that plays a role in intracellular signaling cascades triggered by activated
    receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth
    factor receptor (EGFR) and the insulin receptor (INSR)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IEA--
    GO:0005070SH3/SH2 adaptor activity TAS8596638
    GO:0005515protein binding IPI10978177
    GO:0005543phospholipid binding IEA--
         
    GAB1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GAB1:
     Upregulation of Wnt/beta-caten 

         13 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Gab1):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  growth/size  homeostasis/metabolism  integument  liver/biliary system 
     mortality/aging  muscle  vision/eye 

    GAB1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gab1tm1Ajw for GAB1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GAB1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GAB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GAB1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GAB1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GAB1
    8/112 QIAGEN miScript miRNA Assays for microRNAs that regulate GAB1 (see all 112):
    hsa-miR-361-5p hsa-miR-3152-3p hsa-miR-376b hsa-miR-1224-3p hsa-miR-106a hsa-miR-128 hsa-miR-1260b hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmidGAB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GAB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GAB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GAB1
    Sirion Biotech Customized adenovirus for overexpression of GAB1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GAB1 (see all 13)
    OriGene ORF clones in mouse, rat for GAB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GAB1 (NM_207123)
    Sino Biological Human cDNA Clone for GAB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GAB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAB1
    Sirion Biotech Customized lentivirus for stable overexpression of GAB1 
                         Customized lentivirus expression plasmids for stable overexpression of GAB1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GAB1
    Search LifeMap BioReagents cell lines for GAB1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAB1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GAB1 About   (see all 46)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development HGF signaling pathway
    Development HGF signaling pathway0.78
    Neurotrophin signaling pathway0.36
    Development Neurotrophin family signaling0.45
    Signaling of Hepatocyte Growth Factor Receptor0.35
    Development EGFR signaling via PIP30.40
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)0.31
    Apoptosis and survival NGF signaling pathway0.36
    Renal cell carcinoma0.30
    2ErbB signaling pathway
    ErbB signaling pathway0.52
    ErbB signaling pathway0.52
    3Signaling by FGFR
    Downstream signaling of activated FGFR0.92
    Downstream signal transduction0.90
    Signaling by FGFR0.92
    Signaling by PDGF0.85
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.84
    DAP12 signaling0.91
    Signaling by EGFR in Cancer0.83
    4PIP3 activates AKT signaling
    GAB1 signalosome0.93
    PI3K events in ERBB2 signaling0.88
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    PIP3 activates AKT signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    PI-3K cascade0.88
    Signaling by SCF-KIT0.72
    5IRS-related events
    Insulin receptor signalling cascade0.94
    IGF1R signaling cascade0.92
    IRS-related events0.94
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    IRS-related events triggered by IGF1R0.93
    PI3K Cascade0.86
    IRS-mediated signalling0.92
    Signaling by Insulin receptor0.79

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/10 EMD Millipore Pathways for GAB1 (see all 10)
        Development HGF signaling pathway
    Apoptosis and survival NGF signaling pathway
    Cell adhesion PLAU signaling
    Development FGF-family signaling
    Development FGFR signaling pathway

    5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GAB1 (see all 11)
        HGF Pathway
    Internalin Pathway
    Molecular Mechanisms of Cancer
    GDNF-Family Ligands and Receptor Interactions
    TRKA Signaling

    1 Cell Signaling Technology (CST) Pathway for GAB1
        Tyrosine Kinases / Adaptors

    5/10 GeneGo (Thomson Reuters) Pathways for GAB1 (see all 10)
        Development FGF-family signaling
    Development Neurotrophin family signaling
    Signal transduction AKT signaling
    Translation Regulation of EIF2 activity
    Cell adhesion PLAU signaling

    5/24 BioSystems Pathways for GAB1 (see all 24)
        EGFR1 Signaling Pathway
    Insulin Signaling
    ErbB signaling pathway
    Signaling Pathways in Glioblastoma
    IL-6 Signaling Pathway


    5/41        Reactome Pathways for GAB1 (see all 41)
        Signaling by EGFR in Cancer
    Downstream signal transduction
    IRS-mediated signalling
    Signal Transduction
    Signaling by PDGF


    5         Kegg Pathways  (Kegg details for GAB1):
        ErbB signaling pathway
    Neurotrophin signaling pathway
    Bacterial invasion of epithelial cells
    Proteoglycans in cancer
    Renal cell carcinoma


    GAB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GAB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/58 Interacting proteins for GAB1 (Q134801, 2, 3 ENSP000002629954) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN11Q061241, 2, 3, ENSP000003409444EBI-517684,EBI-297779 MINT-6169355 MINT-6169300 MINT-6169451 MINT-6169344 MINT-8025571 MINT-8029574 MINT-6169406 MINT-6169374 MINT-8029606 MINT-8288652 MINT-8025555 MINT-7026140 MINT-6169338 MINT-6169389 MINT-6169309 MINT-6169327 MINT-6169291 MINT-8029590 I2D: score=10 STRING: ENSP00000340944
    PIK3R1P279862, 3, ENSP000002743354MINT-8028258 MINT-1893011 MINT-8035009 MINT-8030430 MINT-8030445 MINT-8034994 MINT-8028243 I2D: score=6 STRING: ENSP00000274335
    METP085812, 3, ENSP000003172724MINT-58404 I2D: score=4 STRING: ENSP00000317272
    PTPRJQ129132, 3, ENSP000004000104MINT-7026908 I2D: score=2 STRING: ENSP00000400010
    RASA1P209362, 3, ENSP000002743764MINT-8035797 I2D: score=1 STRING: ENSP00000274376
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity ----
    GO:0006979response to oxidative stress IEA--
    GO:0007165signal transduction ----
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007257activation of JUN kinase activity IEA--

    GAB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GAB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GAB1

    10/16 Novoseek inferred chemical compound relationships for GAB1 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 80.7 46 10022866 (3), 9632795 (2), 19050043 (2), 15351743 (2) (see all 29)
    tyrosine 77.4 165 11695994 (8), 11262408 (7), 10194437 (6), 8906793 (5) (see all 62)
    ly294002 62.2 4 19665053 (2), 10022866 (1), 11695994 (1)
    phosphatidylinositol-3,4,5-trisphosphate 61.1 4 10531383 (2), 10194437 (1), 12686619 (1)
    phosphoinositide 56.9 6 11695994 (2), 15784547 (1), 11134009 (1), 15679846 (1)
    phosphotyrosine 55.5 8 10194437 (1), 11323411 (1), 8906793 (1), 12582165 (1) (see all 6)
    wortmannin 54.8 2 10842168 (1)
    gp 130 47.9 7 9632795 (2), 10068651 (2), 11196191 (1), 12855672 (1)
    phenylalanine 29 6 11002419 (1), 15784547 (1), 11403719 (1), 12446613 (1)
    threonine 14.4 13 15379552 (4), 11313945 (2), 17625596 (2), 12748184 (1)

    Search CenterWatch for drugs/clinical trials and news about GAB1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GAB1 gene (2 alternative transcripts): 
    NM_002039.3  NM_207123.2  

    Unigene Clusters for GAB1:

    GRB2-associated binding protein 1
    Hs.80720  [show with all ESTs], Hs.618456
    Unigene Representative Sequences: NM_207123, AK074381
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262995(uc003ijd.3 uc003ije.3 uc011chq.2) ENST00000262994
    ENST00000514639 ENST00000515366 ENST00000505913 ENST00000515388 ENST00000509992
    ENST00000511836 ENST00000512843 ENST00000507334 ENST00000507070 ENST00000510615
    ENST00000508833 ENST00000511109
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GAB1
    8/112 QIAGEN miScript miRNA Assays for microRNAs that regulate GAB1 (see all 112):
    hsa-miR-361-5p hsa-miR-3152-3p hsa-miR-376b hsa-miR-1224-3p hsa-miR-106a hsa-miR-128 hsa-miR-1260b hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmidGAB1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GAB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GAB1
    Clone
    Products:
         
    OriGene clones in human, mouse for GAB1 (see all 13)
    OriGene ORF clones in mouse, rat for GAB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GAB1 (NM_207123)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GAB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAB1
    Sirion Biotech Customized lentivirus for stable overexpression of GAB1 
                         Customized lentivirus expression plasmids for stable overexpression of GAB1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for GAB1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GAB1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAB1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAB1

    Additional mRNA sequence: AK074381.1 

    10 DOTS entries:

    DT.409922  DT.97819196  DT.95367162  DT.97793558  DT.121221662  DT.91925642  DT.91842447  DT.121221692 
    DT.97844118  DT.100641098 

    2 AceView cDNA sequences:

    AK074381 AA969091 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GAB1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:              -     -     -                                                                     
    SP2:              -     -     -                                   -                                 
    SP3:                                                                                                


    ECgene alternative splicing isoforms for GAB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GAB1 expression in normal human tissues (normalized intensities)      GAB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTACTACA
    GAB1 Expression
    About this image


    GAB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Muscle Progenitor Cells Hypobranchial Muscles
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             corpus callosum   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Limb Muscle Progenitor Cells Forelimb Myotome
     
     Colon (Gastrointestinal Tract)
             sigmoid colon mucosa   
     
     Head Mesenchyme (Muscoskeletal System)
             Muscle Progenitor Cells Hypobranchial Muscles

    See GAB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GAB1

    SOURCE GeneReport for Unigene clusters: Hs.80720 Hs.618456
        SABiosciences Expression via Pathway-Focused PCR Arrays including GAB1: 
              Insulin Signaling Pathway in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for GAB1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GAB1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAB1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GAB1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gab11 , 5 growth factor receptor bound protein 2-associated protein more1, 5 84.39(n)1
    90.35(a)1
      8 (38.47 cM)5
    143881  NM_021356.21  NP_067331.21 
     807644345 
    chicken
    (Gallus gallus)
    Aves GAB11 GRB2-associated binding protein 1 82.61(n)
    88.55(a)
      422456  XM_001232601.2  XP_001232602.1 
    lizard
    (Anolis carolinensis)
    Reptilia GAB16
    GRB2-associated binding protein 1
    81(a)
    1 ↔ 1
    5(118551911-118660263)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.75332 Xenopus laevis transcribed sequence with weak similarity more 82.19(n)    CA985958.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.175092 Danio rerio mRNA similar to growth factor receptor more 76.04(n)    BC049429.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dos6
    daughter of sevenless
    11(a)
    1 → many
    3L(2589414-2595590)


    ENSEMBL Gene Tree for GAB1 (if available)
    TreeFam Gene Tree for GAB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GAB1 gene
    GAB32  GAB22  GAB42  
    2 SIMAP similar genes for GAB1 using alignment to 7 protein entries:     GAB1_HUMAN (see all proteins):
    GAB2    GAB4

    GAB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2459 SNPs in GAB1 are shown (see all 2459)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361334
    A breast cancer sample4--see VAR_0361332 T N mis40--------
    VAR_0361324
    A breast cancer sample4--see VAR_0361322 Y C mis40--------
    rs3008941,2
    C,F,A,H--144255998(-) TAAAGG/AGTCAA 2 -- us2k120Minor allele frequency- A:0.25EA NA MN NS WA CSA 995
    rs1812126851,2
    --144256071(+) CAGCAC/TCTAAT 2 -- us2k10--------
    rs1145636061,2
    F--144256314(+) TAATAA/GTTGTG 2 -- us2k11Minor allele frequency- G:0.01NA 120
    rs2008673531,2
    --144256382(+) TTCTT-/TCTCTCT 2 -- us2k10--------
    rs100143581,2
    C--144256398(+) TCTCtC/Tttttt 2 -- us2k1 trp31Minor allele frequency- T:0.00NA 2
    rs1861916051,2
    --144256562(+) CCCGGC/GTAATT 2 -- us2k10--------
    rs759547301,2
    C--144256574(+) TTGTA-/TTTTTA 2 -- us2k10--------
    rs131051561,2
    C,F,H--144256713(+) TCTTCT/CAGTCC 2 -- us2k1 trp317Minor allele frequency- C:0.10NS EA NA WA 2170

    HapMap Linkage Disequilibrium report for GAB1 (144257915 - 144395721 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for GAB1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2576302CNV Deletion19546169
    nsv437941CNV Loss16468122
    nsv830103CNV Loss17160897
    dgv1682e1CNV Complex17122850
    dgv1684e1CNV Complex17122850
    dgv1683e1CNV Complex17122850
    dgv1681e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GAB1
    DNA2.0 Custom Variant and Variant Library Synthesis for GAB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604439    OMIM disorders: --

    20/22 diseases for GAB1 (see all 22):    About MalaCards
    leopard syndrome    atrophic gastritis    noonan syndrome    gastritis
    synovial sarcoma    papillary thyroid carcinoma    narcolepsy    glioblastoma
    sarcoma    multiple myeloma    insulin resistance    myeloma
    endotheliitis    thyroiditis    renal cell carcinoma    asthma
    hepatitis b    colorectal cancer    squamous cell carcinoma    breast cancer


    GAB1 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for GAB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma 17.1 3 14701753 (2), 9890893 (1)
    sarcoma 4.55 1 17210721 (1)
    breast cancer 4.07 2 16715136 (1), 12748184 (1)
    breast carcinoma 0 1 15952937 (1)
    necrosis 0 1 17284447 (1)
    tumors 0 6 18192688 (2), 14668796 (1), 9890893 (1), 12748184 (1) (see all 5)
    cancer 0 2 17211494 (1), 19350053 (1)

    Genetic Association Database (GAD): GAB1
    Human Genome Epidemiology (HuGE) Navigator: GAB1 (9 documents)

    Export disorders for GAB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GAB1 gene, integrated from 9 sources (see all 198):
    (articles sorted by number of sources associating them with GAB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A Grb2-associated docking protein in EGF- and insulin-receptor signalling. (PubMed id 8596638)1, 2, 3, 9 Holgado-Madruga M....Wong A.J. (1996)
    2. Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy. (PubMed id 17211494)1, 4, 9 Goto Y....Hamajima N. (2007)
    3. Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells. (PubMed id 15010462)1, 2, 9 Podar K....Anderson K.C. (2004)
    4. Genome-wide association study identifies three new sus ceptibility loci for adult asthma in the Japanese population. (PubMed id 21804548)1, 4 Hirota T....Tamari M. (2011)
    5. Grb2-associated binder 1 (Gab1) genetic polymorphism, Helicobacter pylori infection, and chronic atrophic gastritis among older adul ts from Germany. (PubMed id 20602450)1, 4 Gao L....Brenner H. (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (2010)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2549 HGNC: 4066 AceView: GAB1.1 Ensembl:ENSG00000109458 euGenes: HUgn2549
    ECgene: GAB1 Kegg: 2549 H-InvDB: GAB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GAB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GAB1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/gab1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GAB1 gene:
    Search GeneIP for patents involving GAB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of GAB1
     EMD Millipore Kits and Assays for the Analysis of GAB1
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GAB1   OriGene RNAi products in human, mouse, rat for GAB1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for GAB1  
     OriGene MassSpec something-or-other for GAB1   OriGene clones in human, mouse for GAB1  
     OriGene qSTAR qPCR primer pairs in human, mouse for GAB1   OriGene Purified Protein for GAB1  
     OriGene ORF clones in mouse, rat for GAB1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GAB1   OriGene Custom Protein Services for GAB1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GAB1
     QIAGEN SeqTarget long-range PCR primers for resequencing GAB1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GAB1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GAB1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GAB1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GAB1
     GenScript Custom Purified and Recombinant Proteins Services for GAB1 GenScript cDNA clones with any tag delivered in your preferred vector for GAB1
     GenScript Custom Assay Services for GAB1 GenScript Superior Antibodies for GAB1
     GenScript Custom overexpressing Cell Line Services for GAB1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for GAB1 

     Regulatory tfbs in GAB1 promoter
     Search Chromatin IP Primers for GAB1
     RT2 qPCR Primer Assay in human, mouse, rat GAB1
     GNC Network for GAB1
     SABiosciences PCR Arrays including human, mouse, rat GAB1
     Search Tocris compounds for GAB1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for GAB1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GAB1 antibodies
     GAB1 proteins
     GAB1 lysates
     Antibodies for GAB1
     See all of Abcam's Antibodies, Kits and Proteins for GAB1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for GAB1
     Antibodies for GAB1
     ELISAs for GAB1
     CLIAs for GAB1
     Search LifeMap BioReagents cell lines for GAB1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GAB1
     SwitchGear 3'UTR luciferase reporter plasmids for GAB1
     SwitchGear Promoter luciferase reporter plasmids for GAB1
     ThermoFisher Antibody for GAB1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GAB1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for GAB1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GAB1
    Customized:
     lentivirus for stable overexpression of GAB1
     lentivirus expression plasmids for stable overexpression of GAB1
     adenovirus for overexpression of GAB1
     Search LSBio for Antibodies for GAB1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GAB1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4