Aliases for GAB1 Gene
External Ids for GAB1 Gene
Previous GeneCards Identifiers for GAB1 Gene
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
GeneCards Summary for GAB1 Gene
GAB1 (GRB2 Associated Binding Protein 1) is a Protein Coding gene. Diseases associated with GAB1 include Leopard Syndrome and Noonan Syndrome 1. Among its related pathways are Development IGF-1 receptor signaling and RET signaling. GO annotations related to this gene include signal transducer activity and SH3/SH2 adaptor activity. An important paralog of this gene is GAB2.
UniProtKB/Swiss-Prot for GAB1 Gene
Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).