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GAB1 Gene

protein-coding GIFtS: 63

GC04P144477

GRB2-associated binding protein 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Descriptions
GRB2-associated binder 1 ^³
GRB2-associated binding protein 1 ^²
Growth factor receptor bound protein 2-associated protein 1 ^³

External Ids
HGNC: 4066¹
Entrez Gene: 2549²
UniProtKB: Q13480³
Ensembl: ENSG00000109458⁷

Search outside databases for aliases for GAB1 gene

Previous GC identifers: GC04P145054 GC04P144619 GC04P144724 GC04P144835 GC04P144615

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for GAB1:

The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein

family. It is an important mediator of branching tubulogenesis and plays a central role in

cellular growth response, transformation and apoptosis. Two transcript variants encoding different

isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: GAB1_HUMAN, Q13480

Function: Probably involved in EGF and insulin receptor signaling

Gene Wiki entry for GAB1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GAB1 gene

Entrez Gene cytogenetic band: 4q31.21 Ensembl cytogenetic band: 4q31.21 HGNC cytogenetic band: 4q31.1

GAB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P144477: (about GC identifiers)

Start:	144,477,500 bp from pter
End:	144,610,729 bp from pter
Size:	133,230 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GAB1_HUMAN, Q13480 (See protein sequence)

Recommended Name: GRB2-associated-binding protein 1

Size: 694 amino acids; 76616 Da

Subunit: Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated

LAT2

Secondary accessions: Q4W5G2 Q6P1W2

Alternative splicing: 2 isoforms: Q13480-1 Q13480-2

Post-translational modifications:

Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the

insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several

proteins that contain SH2 domains¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_002030.2 NP_997006.1

ENSEMBL proteins:

ENSP00000262994 ENSP00000262995

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GAB1)
	Human Recombinant Proteins from Abnova (GAB1)

OriGene Purified Recombinant Human Protein: GAB1

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	EXP	9356464 10648629 10734310 10913131 11606067 14560030 14665621 15574420

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Antibodies for GAB1:

	Invitrogen Antibodies for GAB1
	Millipore Mono- and Polyclonal Antibodies for the study of GAB1
	Sigma-Aldrich Antibodies for GAB1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for GAB1
	Antibodies from Abcam (GAB1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GAB1)
	Novus Biologicals Antibodies for GAB1

Assays for GAB1:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of GAB1
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13480

ProtoNet protein and cluster: Q13480

1 Blocks protein family: IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: GAB1_HUMAN, Q13480

Similarity: Belongs to the GAB family

Similarity: Contains 1 PH domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GAB1)
		Millipore RNAi Products for the Analysis of GAB1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (GAB1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_207123

Applied Biosystems Silencer® siRNAs for GAB1

Sigma-Aldrich siRNA and siRNA Panels for GAB1

Sigma-Aldrich shRNA for GAB1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GAB1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002039
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002039
untagged cDNA clones in CMV expression vector (see all 2): NM_002039

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_207123

UniProtKB/Swiss-Prot: GAB1_HUMAN, Q13480

Function: Probably involved in EGF and insulin receptor signaling

14 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Gab1):

	behavior/neurological	cellular	craniofacial	digestive/alimentary
embryogenesis	growth/size	homeostasis/metabolism	lethality-prenatal/perinatal	life span-post-weaning/aging
liver/biliary system	muscle	skin/coat/nails	vision/eye

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005070	SH3/SH2 adaptor activity	TAS	8596638
GO:0005515	protein binding	IPI	9658397

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/12 Sigma-Aldrich "Your Favorite Gene" Pathways for GAB1 (Your Favorite Gene powered by Ingenuity) (see all 12 )

B Cell Receptor Signaling
Molecular Mechanisms of Cancer
Renal Cell Carcinoma Signaling
Fc Epsilon RI Signaling
Insulin Receptor Signaling

GeneDecks GAB1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for GAB1

5/72 Interacting proteins for GAB1 (Q13480^{1, 2} ENSP00000262995³) via UniProtKB, MINT, and/or STRING (see all 72 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GRB2	P62993², ENSP00000339007³	MINT-58398 MINT-58400 MINT-58399 MINT-58395 STRING (score=.998)
PXN	P49023², ENSP00000228307³	MINT-6169451 MINT-6169502 STRING (score=.96)
PIK3R1	P27986², ENSP00000274335³	MINT-1893011 STRING (score=.995)
MET	P08581², ENSP00000317272³	MINT-58404 STRING (score=.989)
GRAP2	O75791², ENSP00000339186³	MINT-58403 STRING (score=.894)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007173	epidermal growth factor receptor signaling pathway	TAS	8596638
GO:0008283	cell proliferation	TAS	8596638
GO:0008286	insulin receptor signaling pathway	TAS	8596638

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GAB1
10/12 Novoseek chemical compound relationships for GAB1 gene (see all 12 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphatidylinositol	81.19	45	10022866 (3), 9632795 (2), 19050043 (2), 15351743 (2) (see all 28)
tyrosine	77.60	160	11695994 (8), 11262408 (7), 10194437 (6), 8906793 (5) (see all 60)
phosphatidylinositol-3,4,5-trisphosphate	62.27	4	10531383 (2), 10194437 (1), 12686619 (1)
phosphoinositide	58.26	6	11695994 (2), 15784547 (1), 11134009 (1), 15679846 (1)
phosphotyrosine	56.40	8	10194437 (1), 11323411 (1), 8906793 (1), 12582165 (1) (see all 6)
wortmannin	55.94	2	10842168 (1)
gp 130	49.12	7	9632795 (2), 10068651 (2), 11196191 (1), 12855672 (1)
phenylalanine	30.30	6	11002419 (1), 15784547 (1), 11403719 (1), 12446613 (1)
threonine	15.90	13	15379552 (4), 11313945 (2), 17625596 (2), 12748184 (1)
phospholipid	0.00	3	10531383 (1), 12686619 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GAB1)
		Millipore RNAi Products for the Analysis of GAB1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (GAB1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_207123

Sigma-Aldrich siRNA and siRNA Panels for GAB1

Sigma-Aldrich shRNA for GAB1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002039 NM_207123

REFSEQ mRNAs for GAB1 gene (2 alternative transcripts):

NM_002039.3 NM_207123.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002039 NM_207123

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002039
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002039
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002039

Additional cDNA sequence: AK074381.1

10 DOTS entries:

DT.409922 DT.97819196 DT.95367162 DT.97793558 DT.121221662 DT.91925642 DT.121221692 DT.91842447

DT.97844118 DT.100641098

2 AceView cDNA sequences:

AK074381 AA969091

highest scoring ESTs for GAB1:

AL046229 U43885 AA227677 AA331468 AA456435 AA580466 AA904122 AI418769 AI686016 AI826365

Unigene Clusters for GAB1:

GRB2-associated binding protein 1

Hs.80720 [show with all ESTs], Hs.618456 [show with all ESTs]

Unigene Representative Sequences: NM_207123, AK074381

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for GAB1

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b
SP1:					-		-		-
SP2:					-		-		-												-
SP3:

About this scheme

ECgene alternative splicing isoforms for GAB1

2 Ensembl transcripts including schematic representations:

ENST00000262994 ENST00000262995

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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GAB1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GAB1

¹ / ² / ³

18 probe-sets matching GAB1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33997_at²^{, 3}	U95-A	1	1.00	1.00	0.89	0.94	AL049449	0.20	1.00	0.72	1
56088_at²^{, 3}	U95-B	1	1.00	1.00	0.92	1.17	AL046229	1.00	1.00	1.00	1
1249_at²^{, 3}	U95-A	1	1.00	1.00	0.85	0.58	U43885	1.00	1.00	1.00	1
60488_at²^{, 3}	U95-C	1	1.00	1.00	0.84	1.31	AW024807	0.80	1.00	0.91	1
32979_at²^{, 3}	U95-A	1	1.00	1.00	0.87	0.74	U43885	1.00	1.00	1.00	1
56736_r_at²^{, 3}	U95-C	3	1.00	0.96	0.86	1.57	AW022256	0.40	1.00	0.76	1
56682_at²^{, 3}	U95-C	1	0.38	1.00	-0.12	0.78	AA203525	0.20	1.00	0.72	1
225998_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AK022142	0.80	1.00	0.91	1
214987_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL049449	0.20	1.00	0.72	1
229114_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW237741	0.20	1.00	0.72	1
226002_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AK022142	0.80	1.00	0.91	1
207112_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002039	0.60	1.00	0.82	1
225998_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214987_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
229114_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1560382_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
226002_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207112_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks GAB1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAGAAACCCA

SOURCE GeneReport for Unigene clusters: Hs.80720 Hs.618456
Expression variation in blood from EXPOLDB for GAB1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for GAB1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GAB1¹	--	GRB2-associated binding protein 1	92.95(n) 95.2(a)	483808 XM_540929.2 XP_540929.2
chimpanzee (Pan troglodytes)	GAB1¹	--	GRB2-associated binding protein 1	99.63(n) 99.45(a)	461516 XM_517458.2 XP_517458.2
cow (Bos taurus)	GAB1¹	--	GRB2-associated binding protein 1	91.31(n) 95.53(a)	540085 XM_591382.3 XP_591382.3
rat (Rattus norvegicus)	Gab1¹	--	GRB2-associated binding protein 1	82.85(n) 89.05(a)	361388 XM_341667.3 XP_341668.3
mouse (Mus musculus)	Gab1^{1, 5}	8⁵	growth factor receptor bound protein 2-associated protein more^{1, 5}	84.34(n)¹ 90.35(a)¹	14388¹ NM_021356.2¹ NP_067331.2¹ AA408973⁵ AJ250669⁵ (see all 12)

About this table Species with no ortholog for GAB1

ENSEMBL Gene Tree for GAB1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for GAB1 gene

GAB3² GAB2² GAB4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/754 NCBI SNPs in GAB1 are shown (see all 754 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 294)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1397529^1,2	A,C,F,H,O	144611612(+)	`GAAACA/CACAAA`	2	--	ut3¹		12		EA NA MN EU WA NS	826
	rs1877113^1,2	A,C,F,H	144611913(+)	`AAATGG/TTGATG`	2	--	ut3¹		10		MN NS EU EA WA	784
	rs300893^1,2	A,C,F,H	144476566(-)	`CATTCA/GAATGT`	2	--	ng5¹		4		EU EA WA	410
	rs11939029^1,2	C,F,H	144612254(+)	`TGTATA/GCTATC`	2	--	ut3¹		8		NS EA WA	478
	rs2229879^1,2	C,F,H	144579138(+)	`CCCTAC/TAGCAG`	2	T/I	mis¹ ese³		9		MN EU EA WA	902
	rs7665117^1,2	A,C,H	144612715(+)	`TCAAAC/TTTGAA`	2	--	ut3¹		3		EU EA	298
	rs300892^1,2	A,C	144476601(-)	`GGCACC/TGGGGC`	2	--	ng5¹		0	--	--	--	--
	rs28925904^1,2	C,F	144578940(+)	`TCCTCC/TAACAC`	2	P/L	mis¹		6		NS NA	266
	rs12498527^1,2	C,H	144610460(+)	`CTGCCG/CGGTGG`	2	--	ut3¹ ese³		4		EU EA WA	418
	rs28924084^1,2	F	144611457(+)	`ATGTTC/AATAAC`	2	--	ut3¹		5		NS	186

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HapMap Linkage Disequilibrium images for GAB1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 604439

7 Novoseek disease relationships for GAB1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glioblastoma	19.60	3	14701753 (2), 9890893 (1)
sarcoma	6.39	1	17210721 (1)
breast cancer	6.37	2	16715136 (1), 12748184 (1)
necrosis	0.00	1	17284447 (1)
cancer	0.00	2	17211494 (1), 19350053 (1)
tumors	0.00	6	18192688 (2), 14668796 (1), 9890893 (1), 12748184 (1) (see all 5)
breast carcinoma	0.00	1	15952937 (1)

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Human Genome Epidemiology Navigator: GAB1 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/162 PubMed articles for GAB1 gene (see all 162 ):

A Grb2-associated docking protein in EGF- and insulin-receptor signalling. (PubMed id 8596638)^{1, 2, 3, 4} Holgado-Madruga M....Wong A.J. (1996)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{3, 4} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. (PubMed id 12522270)^{3, 4} Salomon A.R.... Peters E.C. (2003)
Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. (PubMed id 12486104)^{3, 4} Brdicka T.... Horejsi V. (2002)
Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2. (PubMed id 11323411)^{1, 3} Cunnick J.M....Wu J. (2001)
A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling. (PubMed id 10648629)^{1, 3} Rodrigues G.A....Schlessinger J. (2000)
Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor. (PubMed id 15952937)^{1, 3} Meng S....Wu J. (2005)
The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase. (PubMed id 10022866)^{1, 3} Maroun C.R....Park M. (1999)
Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases. (PubMed id 10913131)^{1, 3} Lock L.S....Park M. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2549	HGNC: 4066	AceView: GAB1.1	Ensembl:ENSG00000109458	euGenes: HUgn2549
ECgene: GAB1	H-InvDB: GAB1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for GAB1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/gab1/

Licensable Technologies for GAB1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for GAB1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GAB1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GAB1		Antibodies for GAB1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GAB1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GAB1)
	Antibodies (GAB1)
	Chimera RNAi (GAB1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for GAB1

	Recombinant Proteins (GAB1)
	Antibodies (GAB1)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for GAB1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GAB1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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GAB1 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for GAB1

Summaries
for GAB1

Genomic Location
for GAB1

Proteins
for GAB1

Protein Domains/
Families
for GAB1

Gene Function
for GAB1

Pathways & Interactions
for GAB1

Drugs & Compounds
for GAB1

Transcripts
for GAB1

Expression
for GAB1

Orthologs
for GAB1

Paralogs
for GAB1

SNPs/Variants
for GAB1

Disorders & Mutations
for GAB1

Medical News
for GAB1

Publications
for GAB1

Search for GAB1

Genome Databases showing GAB1

Other Databases showing GAB1

Specialized Databases showing GAB1

Licensable Technologies
for GAB1

Services
for GAB1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GAB1 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor GAB1

Summariesfor GAB1

Genomic Locationfor GAB1

Proteinsfor GAB1

Protein Domains/Familiesfor GAB1

Gene Functionfor GAB1

Pathways & Interactionsfor GAB1

Drugs & Compoundsfor GAB1

Transcriptsfor GAB1

Expression for GAB1

Orthologsfor GAB1

Paralogsfor GAB1

SNPs/Variantsfor GAB1

Disorders & Mutationsfor GAB1

Medical Newsfor GAB1

Publicationsfor GAB1

Search for GAB1

Genome Databases showing GAB1

Other Databases showing GAB1

Specialized Databases showing GAB1

Licensable Technologiesfor GAB1

Servicesfor GAB1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GAB1

Summaries
for GAB1

Genomic Location
for GAB1

Proteins
for GAB1

Protein Domains/
Families
for GAB1

Gene Function
for GAB1

Pathways & Interactions
for GAB1

Drugs & Compounds
for GAB1

Transcripts
for GAB1

Expression
for GAB1

Orthologs
for GAB1

Paralogs
for GAB1

SNPs/Variants
for GAB1

Disorders & Mutations
for GAB1

Medical News
for GAB1

Publications
for GAB1

Licensable Technologies
for GAB1

Services
for GAB1