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G6PD Gene

protein-coding GIFtS: 73
GCID: GC0XM153759

Glucose-6-Phosphate Dehydrogenase

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Glucose-6-Phosphate Dehydrogenase¹ ²
EC 1.1.1.49³ ⁸
G6PD1² ⁵
Glucose-6-Phosphate 1-Dehydrogenase²

External Ids:	HGNC: 4057¹	Entrez Gene: 2539²	Ensembl: ENSG00000160211⁷	OMIM: 305900⁵	UniProtKB: P11413³

Export aliases for G6PD gene to outside databases

Previous GC identifers: GC0XM147822 GC0XM150140 GC0XM151344 GC0XM152227 GC0XM153323 GC0XM153412 GC0XM142336

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for G6PD Gene:

This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping

X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing

agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of

G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity

and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic

non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this

gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for G6PD Gene:

G6PD (glucose-6-phosphate dehydrogenase) is a protein-coding gene. Diseases associated with G6PD include senile cataract, and glucosephosphate dehydrogenase deficiency. GO annotations related to this gene include protein homodimerization activity and glucose binding. An important paralog of this gene is H6PD.

UniProtKB/Swiss-Prot: G6PD_HUMAN, P11413

Function: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route

for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide

reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis

Gene Wiki entry for G6PD (Glucose-6-phosphate dehydrogenase) Gene

PharmGKB "VIP" summary for G6PD

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000023.11 NT_011681.17 NC_018934.2

Regulatory elements:

Regulatory transcription factor binding sites in the G6PD gene promoter:
TBP p53 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): G6PD promoter sequence

Search Chromatin IP Primers for G6PD

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat G6PD

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28

G6PD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
G6PD gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM153759: view genomic region (about GC identifiers)

Start:	153,759,606 bp from pter	End:	153,775,787 bp from pter
Size:	16,182 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: G6PD_HUMAN, P11413 (See protein sequence)

Recommended Name: Glucose-6-phosphate 1-dehydrogenase

Size: 515 amino acids; 59257 Da

Subunit: Homotetramer; dimer of dimers

Miscellaneous: Binds two molecules of NADP. The first one is a cosubstrate (bound to the N-terminal domain), the

second is bound to the C-terminal domain and functions as a structural element

Sequence caution: Sequence=AAA63175.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

3 PDB 3D structures from and Proteopedia for G6PD:

1QKI (3D)

2BH9 (3D)

2BHL (3D)

Secondary accessions: D3DWX9 Q16000 Q16765 Q8IU70 Q8IU88 Q8IUA6 Q96PQ2

Alternative splicing: 3 isoforms: P11413-1 P11413-2 P11413-3 (Contains a phosphoserine at position 26)

Explore the universe of human proteins at neXtProt for G6PD: NX_P11413

Explore proteomics data for G6PD at MOPED

Post-translational modifications:

Ubiquitination² at Lys97, Lys171, Lys403

Modification sites at PhosphoSitePlus

Selected DME Specific Peptides for G6PD (P11413) (see all 28)

PDAYERL

GRGGYFD

QIYRIDH

IFTPLLH

See G6PD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_000393.4 NP_001035810.1

ENSEMBL proteins:

ENSP00000377192 ENSP00000377194 ENSP00000358633 ENSP00000395599 ENSP00000400648

ENSP00000394690

Reactome Protein details: P11413

G6PD Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins for G6PD OriGene Protein Over-expression Lysate for G6PD OriGene MassSpec for G6PD OriGene Custom Protein Services for G6PD
	GenScript Custom Purified and Recombinant Proteins Services for G6PD
	Novus Biologicals G6PD Proteins Novus Biologicals G6PD Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for G6PD
	Cloud-Clone Corp. Proteins for G6PD

G6PD Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of G6PD
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for G6PD
	OriGene Antibodies for G6PD OriGene Custom Antibody Services for G6PD
	Novus Biologicals G6PD Antibodies
	Abcam antibodies for G6PD
	Cloud-Clone Corp. Antibodies for G6PD
	ThermoFisher Antibody for G6PD
	LSBio Antibodies in human, mouse, rat for G6PD

G6PD Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for G6PD
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for G6PD
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for G6PD Cloud-Clone Corp. CLIAs for G6PD

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro protein domains:

IPR019796 G6P_DH_AS

IPR022675 G6P_DH_C

IPR001282 G6P_DH

IPR022674 G6P_DH_NAD-bd

IPR016040 NAD(P)-bd_dom

Graphical View of Domain Structure for InterPro Entry P11413

ProtoNet protein and cluster: P11413

1 Blocks protein domain: IPB001282 Glucose-6-phosphate dehydrogenase

UniProtKB/Swiss-Prot: G6PD_HUMAN, P11413

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family

G6PD for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: G6PD_HUMAN, P11413

Function: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route

for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide

reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis

Catalytic activity: D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH

Biophysicochemical properties: Kinetic parameters: KM=7.07 uM for NADP; KM=52 uM for glucose 6-phosphate;

Genatlas biochemistry entry for G6PD:

glucose-6-phosphate dehydrogenase,dimer,or tetramer of a 59.3kDa subunit,cytosolic,ubiquitously expressed,first

step of pentose phosphate,pathway mainly involved in the defense against oxidizing agents through NADPH

production,pentose phosphate pathway

Enzyme Number (IUBMB): EC 1.1.1.49¹ ²

Gene Ontology (GO): Selected molecular function terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004345	glucose-6-phosphate dehydrogenase activity	IMP	2420826
GO:0005515	protein binding	IPI	--
GO:0005536	glucose binding	IMP	5643703
GO:0030246	carbohydrate binding	--	--
GO:0042803	protein homodimerization activity	IPI	15858258

G6PD for ontologies About GeneDecksing

Phenotypes:
9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for G6pdx):

cardiovascular system	cellular	craniofacial	embryogenesis	growth/size/body
hematopoietic system	homeostasis/metabolism	mortality/aging	nervous system

G6PD for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out G6pdx^tm1Luz for G6PD

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for G6PD

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for G6PD

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for G6PD

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for G6PD

miRNA Products:		miRTarBase miRNAs that target G6PD: hsa-mir-1 (MIRT002956), hsa-mir-92b-3p (MIRT040672), hsa-mir-26b-5p (MIRT029662), hsa-mir-335-5p (MIRT018235)

		Block miRNA regulation of human, mouse, rat G6PD using miScript Target Protectors
		6 qRT-PCR Assays for microRNAs that regulate G6PD:
		hsa-miR-206 hsa-miR-1237 hsa-miR-3915 hsa-miR-1207-5p hsa-miR-1 hsa-miR-613
		SwitchGear 3'UTR luciferase reporter plasmid: G6PD 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for G6PD
		Predesigned siRNA for gene silencing in human, mouse, rat G6PD

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for G6PD

Clone Products:		OriGene clones in human, mouse for G6PD (see all 12) OriGene ORF clones in mouse, rat for G6PD OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): G6PD (NM_001042351)
		Sino Biological Human cDNA Clone for G6PD
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for G6PD
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat G6PD

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for G6PD
		Browse ESI BIO Cell Lines and PureStem Progenitors for G6PD

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for G6PD

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	4
cytosol	4
plasma membrane	4
mitochondrion	3
chloroplast	2
endoplasmic reticulum	2
extracellular	2
nucleus	2
peroxisome	2
golgi apparatus	1
vacuole	1

About this image

Gene Ontology (GO): Selected cellular component terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IDA	--
GO:0005813	centrosome	--	--
GO:0005829	cytosol	TAS	--
GO:0009898	cytoplasmic side of plasma membrane	IDA	743300

G6PD for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for G6PD About (see all 9)

See pathways by source

SuperPath

Contained pathways About

Carbon metabolism

	Carbon metabolism	0.38			Pentose Phosphate Pathway (Erythrocyte)	0.00
	pentose phosphate pathway (oxidative branch)	0.00

Glutathione metabolism

Glutathione metabolism

0.65

Glutathione metabolism

0.45

Metabolism

Metabolism

0.38

Metabolic pathways

0.38

Pentose Phosphate Pathway (WikiPathways)

Pentose Phosphate Pathway

Pentose phosphate pathway (hexose monophosphate shunt)

0.00

Pentose phosphate pathway (KEGG)

Pentose phosphate pathway

pentose phosphate pathway

0.00

Pathways by source See SuperPaths
Show all pathways

1 Cell Signaling Technology (CST) Pathway for G6PD

Glucose / Energy Metabolism

5 BioSystems Pathways for G6PD

	Sulfation Biotransformation Reaction
	pentose phosphate pathway
	pentose phosphate pathway (oxidative branch)
	Glutathione metabolism
	Pentose Phosphate Pathway

1 Reactome Pathway for G6PD

Pentose phosphate pathway (hexose monophosphate shunt)

2 PharmGKB Pathways for G6PD

	Methylene Blue Pathway, Pharmacodynamics
	Pentose Phosphate Pathway (Erythrocyte)

4 Kegg Pathways (Kegg details for G6PD):

	Pentose phosphate pathway
	Glutathione metabolism
	Metabolic pathways
	Carbon metabolism

UniProtKB/Swiss-Prot: G6PD_HUMAN, P11413

Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate

(oxidative stage): step 1/3

G6PD for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Arrays including G6PD (see all 6):

Nephrotoxicity in human mouse rat

Estrogen Receptor Signaling in human mouse rat

Cancer PathwayFinder in human mouse rat

Fatty Liver in human mouse rat

Diabetes in human mouse rat

Interactions:

GeneGlobe Interaction Network for G6PD

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for G6PD (P11413^{1, 2, 3} ENSP00000377192⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 74)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HSPB1	P04792¹^,²^,³, ENSP00000248553⁴	EBI-4289891,EBI-352682 MINT-8142253 MINT-8142240 I2D: score=2 STRING: ENSP00000248553
GPI	P06744³, ENSP00000348877⁴	I2D: score=1 STRING: ENSP00000348877
PGLS	O95336³, ENSP00000252603⁴	I2D: score=1 STRING: ENSP00000252603
SLC25A1	P53007³, ENSP00000215882⁴	I2D: score=1 STRING: ENSP00000215882
SUMO4	Q6EEV6³, ENSP00000318635⁴	I2D: score=1 STRING: ENSP00000318635

About this table

Gene Ontology (GO): Selected biological process terms (see all 23): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001816	cytokine production	IMP	17361089
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006006	glucose metabolic process	--	--
GO:0006098	pentose-phosphate shunt	TAS	--
GO:0006629	lipid metabolic process	TAS	17361089

G6PD for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for G6PD

8 HMDB Compounds for G6PD About this table

Compound	Synonyms	CAS #	PubMed Ids
6-Phosphonoglucono-D-lactone	6-(dihydrogen phosphate)-(8CI)-D-Gluconic acid delta-lactone (see all 13)	2641-81-8	--
Beta-D-Glucose 6-phosphate	beta-D-glucose 6-(dihydrogen phosphate) (see all 3)	--	--
Gluconolactone	1,5-Gluconolactone (see all 35)	90-80-2	--
Glucose 6-phosphate	D(+)-Glucopyranose 6-phosphate (see all 11)	56-73-5	--
NADP	Adenine-nicotinamide dinucleotide phosphate (see all 18)	53-59-8	--
NADPH	2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)	53-57-6	--
Phenol	acide carbolique (see all 51)	108-95-2	--
Pyridoxal 5'-phosphate	Apolon B6 (see all 27)	54-47-7	--

2 DrugBank Compounds for G6PD About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
2'-Monophosphoadenosine 5'-Diphosphoribose	--	--	target	--	17139284 17016423
Hydroxyacetic Acid	--	79-14-1	target	--	17139284 17016423

149 Novoseek inferred chemical compound relationships for G6PD gene (see top 10) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glucose 6-phosphate	99.1	3680	8790979 (6), 12902098 (6), 12438773 (6), 12476860 (6) (see all 99)
6-phosphogluconate	86	89	8790979 (4), 8955144 (2), 1637668 (2), 7875715 (2) (see all 56)
primaquine	81.1	80	1986741 (4), 15330059 (3), 8036681 (3), 16968914 (3) (see all 33)
nadph	78.1	216	14614139 (4), 17675065 (4), 2297768 (3), 2269430 (3) (see all 99)
nadp+	74.8	64	16934959 (3), 15858258 (3), 14980702 (2), 2403336 (2) (see all 33)
neotetrazolium	66.7	4	7930518 (1), 10582692 (1), 9306960 (1)
2',5'-adp	64.4	4	15003259 (1), 12696635 (1), 11237690 (1), 14704475 (1)
superoxide	62.7	136	17675065 (4), 8899868 (3), 14973180 (2), 10395749 (2) (see all 99)
o-ethylhydroxylamine	62.3	1	10087986 (1)
pyruvate	61.3	80	1434530 (4), 2168088 (2), 2049468 (2), 8869370 (2) (see all 57)
sn mesoporphyrin	61.3	4	11731664 (1), 11433050 (1), 9565434 (1)
epiandrosterone	60.5	5	9523930 (2), 8251763 (1), 12475725 (1)
formazan	59.8	7	12654062 (2), 15906718 (1), 12791063 (1), 10407579 (1) (see all 5)
no-dimethylhydroxylamine	59.8	2	9137808 (1)
isocitrate	59.1	25	16078188 (2), 19662196 (2), 8351966 (2), 8010517 (1) (see all 20)
gssg	57.8	33	15882454 (3), 12539568 (3), 17852823 (2), 8939405 (2) (see all 16)
dapsone	56.6	29	8033379 (3), 19112496 (2), 20480797 (2), 19431080 (2) (see all 14)
ribose 5-phosphate	56.5	5	17017935 (1), 7602782 (1), 10709108 (1)
tafenoquine	54.9	2	16225366 (1), 11438908 (1)
galactose-6-phosphate	54.4	1	8141125 (1)
phenazine methosulfate	54.2	8	17083911 (1), 1368798 (1), 1695837 (1), 12791063 (1) (see all 5)
6-phosphogluconolactone	54.1	2	1991519 (1), 9717519 (1)
glyceraldehyde 3-phosphate	51.8	26	17884296 (1), 18775465 (1), 19778366 (1), 1471744 (1) (see all 19)
lactate	51.2	82	8735285 (3), 14643871 (2), 15714131 (2), 8910257 (2) (see all 67)
malate	50.5	25	16920803 (3), 8010517 (1), 9542633 (1), 10561850 (1) (see all 18)
8-aminoquinoline	50.5	3	2246194 (1), 12041544 (1)
hydroxyethyl disulfide	50.5	7	17516514 (2), 12643793 (1), 10891335 (1)
diamide	50.4	7	2167082 (1), 16121036 (1), 10900126 (1), 18945214 (1)
dhea	49.4	44	9052415 (5), 19680996 (2), 10891335 (2), 12475725 (2) (see all 19)
iodonitrotetrazolium	47.8	3	17083911 (1), 18324728 (1)
6-aminonicotinamide	47.7	4	19429815 (1), 17675065 (1), 12524266 (1), 19369702 (1)
nadh	47.3	17	1690278 (1), 2111714 (1), 1533182 (1), 9832086 (1) (see all 15)
oxygen	44.9	66	15866284 (4), 10582692 (2), 1810265 (2), 10219051 (2) (see all 38)
cellulose acetate	43.7	5	9604591 (1), 12737938 (1), 7893175 (1), 17344674 (1)
malondialdehyde	43.5	66	16298874 (2), 16489259 (2), 19524183 (2), 12415567 (2) (see all 28)
actb	42.7	4	16600798 (1), 11827948 (1), 16211407 (1), 18671841 (1)
ascorbic acid	42.4	32	17331345 (2), 8463353 (1), 8436894 (1), 2343579 (1) (see all 21)
h2o2	42.3	25	9801159 (2), 8316633 (1), 8955144 (1), 11978492 (1) (see all 19)
23-diphosphoglycerate	42.1	8	12002634 (2), 8907409 (1), 8247195 (1), 9432020 (1) (see all 5)
nad+	41.8	19	2403336 (3), 10082668 (2), 1533182 (1), 8907409 (1) (see all 11)
glycerol 3-phosphate	41.4	14	1834654 (2), 8351966 (2), 8870674 (1), 12643487 (1) (see all 12)
methylene	40.8	23	11824767 (2), 15787927 (1), 16225660 (1), 16917918 (1) (see all 17)
glucose	39.4	100	11007790 (7), 20032314 (6), 1874475 (3), 8899868 (3) (see all 54)
chloroquine	38.1	12	15027776 (1), 1708959 (1), 16179085 (1), 18682739 (1) (see all 7)
tert-butylhydroperoxide	36.2	12	9626567 (5), 19490763 (3), 8908366 (1), 8496623 (1)
lipid	35.7	42	15622767 (4), 15322329 (2), 1808415 (2), 17361089 (2) (see all 31)
cumene hydroperoxide	35.6	2	10862502 (1), 8496623 (1)
uric acid	35.3	4	7927548 (2), 10900719 (1), 2019023 (1)
fansidar	33.7	2	1895921 (1)
thiobarbituric acid	33.3	9	14613721 (1), 10378448 (1), 20084018 (1), 7910380 (1) (see all 6)
5-cyano-2,3-ditolyltetrazolium chloride	33	1	16046670 (1)
atp	33	50	18513544 (3), 9821385 (2), 10762681 (2), 2109668 (1) (see all 27)
mefloquine	32.8	3	10772204 (1), 10686964 (1)
vitamin-e	32.7	28	10630920 (3), 18946458 (3), 7927548 (2), 19675711 (2) (see all 16)
prpp	32.6	4	8207962 (1), 1381200 (1), 16359766 (1)
glucose 1,6-bisphosphate	32.6	1	1533182 (1)
mevalonolactone	32.6	2	12558061 (1)
dehydroascorbic acid	31.9	7	16900400 (2), 17331345 (1), 1993652 (1)
sulfadoxine/pyrimethamine	31.8	3	1895921 (1), 15183620 (1)
fructose-1,6-bisphosphate	31.2	1	8283448 (1)
nitroblue tetrazolium	30.4	9	11780463 (1), 15738610 (1), 7706683 (1), 9158663 (1) (see all 5)
succinate	29.8	15	8351966 (2), 10561850 (1), 17169444 (1), 2004612 (1) (see all 13)
quinine	29.4	7	8215232 (2), 8953071 (2), 19589177 (1)
3alpha-hydroxysteroid	29.2	3	2009030 (1), 8237468 (1), 7504419 (1)
galactose-1-phosphate	28.4	4	10839768 (1), 11271380 (1), 8052150 (1)
aluminium phosphide	27.8	3	10496516 (2), 17183055 (1)
4-hydroxynonenal	27	2	15293559 (1), 17158879 (1)
atovaquone	25.7	2	8604455 (1), 19883154 (1)
halofantrine	25.5	1	9093424 (1)
alpha lipoic acid	25	5	7632170 (2), 12643793 (1), 20226470 (1), 18269318 (1)
artesunate	21.9	1	17925871 (1)
diphenyleneiodonium	21.1	4	15358777 (1), 19819434 (1)
nitrofurantoin	19.8	4	2089833 (2), 11938545 (1), 11401180 (1)
2-deoxyglucose	17.2	5	2136308 (2), 15152941 (1), 16442489 (1)
mannitol	16.8	7	1308788 (3), 2375205 (2), 16046162 (1), 19058613 (1)
dmsa	15.3	3	7932916 (2), 1309865 (1)
n acetylcysteine	14.1	9	9523930 (3), 15598086 (1)
sulfamethoxazole	13.8	5	7638153 (1), 15073793 (1), 16387153 (1)
adenylate	11.7	11	8579339 (1), 8907409 (1), 9821385 (1), 15256026 (1) (see all 9)
zinc protoporphyrin	9.38	1	9267885 (1)
dipyrone	7.64	2	11440730 (1), 18343605 (1)
rapamycin	5.41	2	12599018 (1), 16888724 (1)
alpha-tocopheryl acetate	4.74	1	16971139 (1)
sodium nitroprusside	4.6	2	17018880 (1)
nifedipine	4.22	3	2103781 (2), 15550513 (1)
phosphatidylserine	4.17	4	11243134 (2), 15622767 (1)
alpha tocopherol	4.07	8	16971139 (4), 17485193 (1), 18077195 (1)
serine	3.59	2	17897481 (1), 7849299 (1)
citrate	1.91	9	16920803 (2), 8640958 (1), 15556078 (1), 15268971 (1) (see all 8)
vitamin b12	1.82	7	1700661 (1), 7756942 (1), 8546377 (1), 8090251 (1) (see all 5)
cyclophosphamide	1.57	1	7728738 (1)
estrogen	1.52	8	1914015 (3), 12547330 (1), 9195474 (1)
epinephrine	1.39	1	7654215 (1)
sulfonamide	0.837	4	18569349 (2), 20480797 (1)
hypoxanthine	0.278	2	2339126 (1)
agar	0	3	16868367 (1), 17344674 (1)
kainate	0	1	1992290 (1)
cefazolin	0	1	12696635 (1)
thyroxine	0	10	10885037 (1), 17701928 (1), 11059392 (1), 18182649 (1)
n-ethylmaleimide	0	6	16121036 (1), 17101723 (1)
actinomycin d	0	2	11463792 (1)
aspartate	0	6	1471744 (1), 8097373 (1), 11985579 (1), 12369486 (1) (see all 5)
ribavirin	0	7	15122753 (4), 16597599 (1), 17107736 (1)
clindamycin	0	2	8604455 (1)
polyethylene glycol	0	7	1872884 (1), 11445570 (1), 2403336 (1), 12383480 (1) (see all 5)
azathioprine	0	1	8872476 (1)
testosterone	0	3	14633623 (1), 12507254 (1), 1651223 (1)
glutaraldehyde	0	3	2192713 (1), 12798896 (1)
creatinine	0	11	16920803 (2), 7524809 (1), 7774949 (1), 7888166 (1) (see all 8)
cisplatin	0	3	8293421 (1)
doxorubicin	0	1	8648264 (1)
carnitine	0	3	11400758 (1), 16020499 (1), 12705401 (1)
lactose	0	5	8991858 (2)
fumarate	0	2	7810807 (1), 17027989 (1)
tamoxifen	0	2	2297768 (2)
pyrimethamine	0	2	10772204 (1)
methimazole	0	2	8640958 (1), 17046053 (1)
folate	0	3	8815749 (1), 7756942 (1), 8546377 (1)
phosphatidylcholine	0	3	11243134 (2)
isoniazid	0	3	1841426 (2), 20485961 (1)
gemfibrozil	0	2	8355562 (1)
carbon	0	3	8900402 (1), 10075811 (1), 8119488 (1)
formate	0	1	9854842 (1)
midazolam	0	3	10022752 (1), 19475242 (1), 12020046 (1)
glycerol	0	1	2205614 (1)
ceftriaxone	0	1	12696635 (1)
valine	0	1	15989236 (1)
sodium azide	0	1	16046670 (1)
purine nucleoside	0	1	9542633 (1)
pentamidine	0	1	8604455 (1)
glibenclamide	0	4	8562390 (1)
pioglitazone	0	1	1538716 (1)
paclitaxel	0	1	15152941 (1)
glutamine	0	1	12232660 (1)
acetone	0	1	10862502 (1)
alpha-ketoglutarate	0	1	8283448 (1)
tocopherol	0	1	2251794 (1)
guanidine hydrochloride	0	7	15843172 (2), 15952936 (1)
aspirin	0	13	1803794 (3), 1708959 (1), 18852594 (1), 10920507 (1) (see all 5)
salicylic acid	0	4	10920507 (4)
phenobarbital	0	1	15716985 (1)
scopolamine	0	2	12020046 (2)
ethidium bromide	0	1	8193373 (1)
vinblastine	0	1	16888724 (1)
egcg	0	3	16506813 (1), 18313308 (1)
acetaminophen	0	6	8941205 (3), 1308788 (1), 12013368 (1), 11221636 (1)
dmso	0	2	1370718 (1)
trimethoprim	0	2	8604455 (1)
starch	0	3	8188314 (1), 20445092 (1), 8537082 (1)

Selected PharmGKB related drug/compound annotations for G6PD gene (see all 21) About this table

Drug/compound	PharmGKB Annotation
artesunate	CA
chloroquine
chlorproguanil	CA
dapsone	CA
glibenclamide
methylene blue
nalidixic acid
nitrofurantoin
norfloxacin
pegloticase

G6PD for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for G6PD gene (2 alternative transcripts):

NM_000402.4 NM_001042351.2

Unigene Cluster for G6PD:

Glucose-6-phosphate dehydrogenase

Hs.461047 [show with all ESTs]

Unigene Representative Sequence: X03674

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000393562(uc004flx.1 uc004fly.1) ENST00000393564 ENST00000369620

ENST00000490651 ENST00000439227 ENST00000440967 ENST00000489497 ENST00000433845

ENST00000497281 ENST00000488434

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		Block miRNA regulation of human, mouse, rat G6PD using miScript Target Protectors
		6 qRT-PCR Assays for microRNAs that regulate G6PD:
		hsa-miR-206 hsa-miR-1237 hsa-miR-3915 hsa-miR-1207-5p hsa-miR-1 hsa-miR-613
		SwitchGear 3'UTR luciferase reporter plasmid: G6PD 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for G6PD
		Predesigned siRNA for gene silencing in human, mouse, rat G6PD

Clone Products:		OriGene clones in human, mouse for G6PD (see all 12) OriGene ORF clones in mouse, rat for G6PD OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): G6PD (NM_001042351)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for G6PD
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat G6PD

Primer Products:		OriGene qPCR primer pairs and template standards for G6PD OriGene qSTAR qPCR primer pairs in human, mouse for G6PD
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat G6PD
		QuantiTect SYBR Green Assays in human, mouse, rat G6PD
		QuantiFast Probe-based Assays in human, mouse, rat G6PD

Additional mRNA sequence:

AK292304.1 AK302341.1 BC000337.2 M21248.1 M27940.1 S58359.1 X03674.1

22 DOTS entries:

DT.217832 DT.121293712 DT.100886708 DT.100886711 DT.97760191 DT.95181123 DT.91651365 DT.95181033

DT.99948311 DT.100886676 DT.100886712 DT.121294781 DT.92459873 DT.100886703 DT.121293725 DT.95181124

DT.100886697 DT.121293821 DT.121294265 DT.80100454 DT.95181111 DT.95181122

Selected AceView cDNA sequences (see all 494):

BU543660 BI829464 BI836599 BP356172 BQ952738 BQ053958 F12517 BF219760

BM554297 CD251772 BE729283 BG252525 BU189943 BI829519 CB107414 AA311501

BM676989 BE276689 BQ941900 BU175422 AL527352 CA488022 BI333724 BQ052829

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for G6PD (see all 8) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8a	·	8b	·	8c	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14a	·	14b
SP1:
SP2:					-
SP3:					-
SP4:
SP5:

ECgene alternative splicing isoforms for G6PD

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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G6PD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CCCTTGAACC

About this image

G6PD expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 3) fully expand


Testis (Reproductive System)
Leydig Cells Testis Interstitium

Ovary (Reproductive System)
Ovarian Mesenchymal Stroma Cells Ovary Interstitium

Bone (Muscoskeletal System)
Bone Marrow

G6PD Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

G6PD Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.461047

UniProtKB/Swiss-Prot: G6PD_HUMAN, P11413

Tissue specificity: Isoform Long is found in lymphoblasts, granulocytes and sperm

Pathway & Disease-focused RT² Profiler PCR Arrays including G6PD (see all 6):

Nephrotoxicity in human mouse rat

Estrogen Receptor Signaling in human mouse rat

Cancer PathwayFinder in human mouse rat

Fatty Liver in human mouse rat

Diabetes in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for G6PD OriGene qSTAR qPCR primer pairs in human, mouse for G6PD
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat G6PD
		QuantiTect SYBR Green Assays in human, mouse, rat G6PD
		QuantiFast Probe-based Assays in human, mouse, rat G6PD

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for G6PD

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for G6PD gene from Selected species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	G6pdx^{1 , 5}	glucose-6-phosphate dehydrogenase X-linked^{1, 5}	87.44(n)¹ 93.79(a)¹		X (38.00 cM)⁵ 14381¹ NM_008062.2¹ NP_032088.1¹ 74409483⁵
lizard (Anolis carolinensis)	Reptilia	G6PD⁶	glucose-6-phosphate dehydrogenase	79(a)	1 ↔ 1	2(89699583-89736533)
African clawed frog (Xenopus laevis)	Amphibia	BC059324.1²	--	75.59(n)		BC059324.1
zebrafish (Danio rerio)	Actinopterygii	g6pd¹	glucose-6-phosphate dehydrogenase	69.76(n) 76.4(a)		570579 XM_694076.5 XP_699168.3
fruit fly (Drosophila melanogaster)	Insecta	Zw^{1 , 3}	pentose-phosphate shunt glucose-6-phosphate 1-dehydrogenase³ Zwischenferment¹	65(a) (best of 2)³ 68.62(n)¹ 65.18(a)¹		1 18D13³ 32974¹ NM_078687.1¹ NP_523411.1¹
worm (Caenorhabditis elegans)	Secernentea	B0035.5³ gspd-1¹	glucose-6-phosphate-1-dehydrogenase³ gspd-1¹	60(a)³ 58.63(n)¹ 61.75(a)¹		IV(11317595-11319951)³ 178046¹ NM_069728.4¹ NP_502129.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	ZWF1¹	ZWF1	54.68(n) 49.79(a)		855480 NP_014158.1
thale cress (Arabidopsis thaliana)	eudicotyledons	G6PD6¹	G6PD6	54.99(n) 55.98(a)		834076 NM_123441.2 NP_198892.1
rice (Oryza sativa)	Liliopsida	AK100545.1²	--	73.15(n)		AK100545.1

ENSEMBL Gene Tree for G6PD (if available)
TreeFam Gene Tree for G6PD (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for G6PD gene

H6PD²

1 SIMAP similar gene for G6PD using alignment to 16 protein entries: G6PD_HUMAN (see all proteins):

H6PD

G6PD for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Polymorphic Variants from UniProtKB/Swiss-Prot

G6PD_HUMAN, P11413: The sequence shown is that of variant B, the most common variant

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_002475⁴		Anemia, non-spherocytic hemolytic, due to G6PD deficiency (NSHA)⁴	--	see VAR_002475	2	R P	mis⁴		0	--	--	--	--
VAR_002500⁴		Anemia, non-spherocytic hemolytic, due to G6PD deficiency (NSHA)⁴	--	see VAR_002500	2	V L	mis⁴		0	--	--	--	--
VAR_002498⁴		Anemia, non-spherocytic hemolytic, due to G6PD deficiency (NSHA)⁴	--	see VAR_002498	2	R C	mis⁴		0	--	--	--	--
VAR_002506⁴		Anemia, non-spherocytic hemolytic, due to G6PD deficiency (NSHA)⁴	--	see VAR_002506	2	R P	mis⁴		0	--	--	--	--
VAR_002504⁴		Anemia, non-spherocytic hemolytic, due to G6PD deficiency (NSHA)⁴	--	see VAR_002504	2	G D	mis⁴		0	--	--	--	--
rs76723693^1,2,,4	C,F	pathogenic¹	153629722(-)	`GTACCT/CGGACG`	4	/P /L	mis¹		1		NA	4544
rs137852330^1,2	C	pathogenic¹	153631087(-)	`TCTACC/TGCATC`	4	R C	mis¹		0	--	--	--	--
rs1050829^1,2,,4	C,F,A,H	pathogenic¹	153631974(-)	`CATNGA/GATGCC`	4	N D	mis¹ ese³		17		MN NS NA WA	6364
rs1050828^1,2,,4	C,F,H	pathogenic¹	153632699(-)	`TCATCG/ATGGGC`	4	/M /V	mis¹		26		MN NS EA NA	7898
rs72554665^1,2,,4	C	untested¹	153628966(-)	`GCTCCC/G/TTGAGG`	6	P R L	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for G6PD (153759606 - 153775787 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for G6PD: About this table

Variant ID	Type	Subtype	PubMed ID
nsv508816	CNV	Insertion	20534489
nsv519042	CNV	Gain	19592680
esv33199	CNV	Gain+Loss	17666407
esv33784	CNV	Gain+Loss	17666407

Human Gene Mutation Database (HGMD): G6PD
Locus Specific Mutation Databases (LSDB): G6PD

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing G6PD

DNA2.0 Custom Variant and Variant Library Synthesis for G6PD

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 305900
OMIM disorders: 300908 134700 611162
UniProtKB/Swiss-Prot: G6PD_HUMAN, P11413

Anemia, non-spherocytic hemolytic, due to G6PD deficiency (NSHA) [MIM:300908]: A disease characterized by

G6PD deficiency, acute hemolytic anemia, fatigue, back pain, and jaundice. In most patients, the disease is

triggered by an exogenous agent, such as some drugs, food, or infection. Increased unconjugated bilirubin,

lactate dehydrogenase, and reticulocytosis are markers of the disorder. Although G6PD deficiency can be

life-threatening, most patients are asymptomatic throughout their life. Note=The disease is caused by mutations

affecting the gene represented in this entry. Deficiency of G6PD is associated with hemolytic anemia in two

different situations. First, in areas in which malaria has been endemic, G6PD-deficiency alleles have reached

high frequencies (1% to 50%) and deficient individuals, though essentially asymptomatic in the steady state, have

a high risk of acute hemolytic attacks. Secondly, sporadic cases of G6PD deficiency occur at a very low

frequencies, and they usually present a more severe phenotype. Several types of NSHA are recognized. Class-I

variants are associated with severe NSHA; class-II have an activity <10% of normal; class-III have an activity of

10% to 60% of normal; class-IV have near normal activity

Selected diseases for G6PD (see all 187):
About MalaCards

senile cataract glucosephosphate dehydrogenase deficiency kernicterus congenital nonspherocytic hemolytic anemia

blood group incompatibility favism malaria due to g6pd deficiency hemolytic anemia

hemoglobinopathy neonatal jaundice blackwater fever boutonneuse fever

diabetic cataract nonarteritic anterior ischemic optic neuropathy pyruvate kinase deficiency glucosephosphate isomerase deficiency

hepatitis a thalassemia minor gilbert syndrome aseptic meningitis

10 diseases from the University of Copenhagen DISEASES database for G6PD:

Glucosephosphate dehydrogenase deficiency Neonatal jaundice Anemia Bilirubin metabolic disorder

Malaria Kernicterus Color blindness Thalassemia

Diabetes mellitus Cancer

G6PD for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

Selected Novoseek inferred disease relationships for G6PD gene (see all 99) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
g6pd deficiency	99.3	2782	12971572 (11), 11903742 (10), 19789650 (9), 18582416 (9) (see all 99)
favism	94	58	8991858 (3), 15957246 (2), 16513531 (2), 10571945 (2) (see all 29)
enzymopathy	92.4	86	8813716 (2), 2386513 (1), 2393028 (1), 8235390 (1) (see all 48)
jaundice neonatal	90.8	156	11317924 (6), 1468858 (5), 16255851 (4), 19422023 (3) (see all 70)
kernicterus	88.2	71	12729287 (4), 20113600 (3), 17483701 (3), 12208096 (2) (see all 38)
anemia hemolytic	87.8	196	19494543 (4), 15645702 (3), 9332310 (3), 18677765 (3) (see all 99)
hemolysis	87	294	20118060 (4), 11783956 (4), 8703811 (3), 16603783 (3) (see all 99)
enzyme deficiency	84.2	60	8579339 (1), 8639919 (1), 12737943 (1), 2386511 (1) (see all 41)
hyperbilirubinemia	83	134	20051781 (4), 10091404 (3), 17483701 (3), 12368976 (3) (see all 63)
blackwater fever	75.4	3	7859663 (1), 9402415 (1), 19589177 (1)

Genatlas disease: G6PD

anemia,non spherocytic,congenital,hemolytic anemia,favism

Genetic Association Database (GAD): G6PD
Human Genome Epidemiology (HuGE) Navigator: G6PD (90 documents)

Export disorders for G6PD gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for G6PD gene, integrated from 10 sources (see all 1672):
(articles sorted by number of sources associating them with G6PD)

Utopia: connect your pdf to the dynamic
world of online information

A novel single-base mutation in the glucose 6-phosphate dehydrogenase gene is associated with chronic non-spherocytic haemolytic anaemia. (PubMed id 7959695)^{1, 2, 4} Filosa S....Martini G. (Hum. Genet. 1994)
Human glucose-6-phosphate dehydrogenase: primary structure and cDNA cloning. (PubMed id 3012556)^{1, 2, 3} Takizawa T.... Yoshida A. (Proc. Natl. Acad. Sci. U.S.A. 1986)
Structural analysis of the X-linked gene encoding human glucose 6- phosphate dehydrogenase. (PubMed id 2428611)^{1, 2, 3} Martini G.... Persico M.G. (EMBO J. 1986)
Glucose-6-phosphate dehydrogenase (G6PD) mutations in Thailand: G6PD Viangchan (871G>A) is the most common deficiency variant in the Thai population. (PubMed id 11793482)^{1, 4, 9} Nuchprayoon I....Nuchprayoon S. (Hum. Mutat. 2002)
The impact of phenotypic and genotypic G6PD deficiency on risk of plasmodium vivax infection: a case-control study amongst Afghan refugees in Pakistan. (PubMed id 20520804)^{1, 4, 9} Leslie T....Rowland M. (PLoS Med. 2010)
Glucose-6-phosphate dehydrogenase (G6PD) variants in Malaysian Malays. (PubMed id 12497642)^{1, 4, 9} Ainoon O....Hamidah N.H. (Hum. Mutat. 2003)
Molecular study of eight Japanese cases of glucose-6-phosphate dehydrogenase deficiency by nonradioisotopic single-strand conformation polymorphism analysis. (PubMed id 8193373)^{1, 2, 9} Hirono A.... Kubota K. (Blood 1994)
The prevalence of factor V Leiden, prothrombin G20210A and methylenetetrahydrofolate reductase polymorphism C677T among G6PD deficient individuals from Western Iran. (PubMed id 19219640)^{1, 4, 9} Mozafari H....Muniz A. (Mol. Biol. Rep. 2009)
Molecular heterogeneity of glucose-6-phosphate dehydrogenase (G6PD) variants in the south of Thailand and identification of a novel variant (G6PD Songklanagarind). (PubMed id 15727905)^{1, 4, 9} Laosombat V....Matsuo M. (amp 2005)
Molecular basis of G6PD deficiency in India. (PubMed id 15315792)^{1, 4, 9} Sukumar S....Mohanty D. (amp 2004)

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Aliases
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Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2539	HGNC: 4057	AceView: G6PD	Ensembl:ENSG00000160211	euGenes: HUgn2539
ECgene: G6PD	Kegg: 2539	H-InvDB: G6PD

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for G6PD	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for G6PD	Genetics and Cytogenetics in Oncology and Haematology
G6PD	http://rialto.com/g6pd/
G6PDdb	http://www.bioinf.org.uk/g6pd/
GeneReviews	http://www.ncbi.nlm.nih.gov/books/NBK1116/?term=G6PD[genesymbol]
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=G6PD

Intellectual Property for G6PD gene
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Patent Information for G6PD gene:
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G6PD Gene

Glucose-6-Phosphate Dehydrogenase

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G6PD Gene

Glucose-6-Phosphate Dehydrogenase

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