G6PC3 Gene
protein-coding GIFtS: 56
GCID: GC17P042148
|
|
glucose 6 phosphatase, catalytic, 3
| |
Aliases for G6PC3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
| This gene clusters with an RNA gene Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Glucose 6 Phosphatase, Catalytic, 31 2 | | EC 3.1.3.93 8 | | UGRP1 2 3 5 | | SCN42 5 | | Ubiquitous Glucose-6-Phosphatase Catalytic Subunit-Related Protein2 3 | | Glucose-6-Phosphatase 32 | | G6Pase-Beta1 | | Glucose-6-Phosphatase Catalytic Subunit 32 | | G-6-Pase 32 3 | | Ubiquitously Expressed G6Pase Catalytic Subunit-Related Protein2 | | G6Pase 32 3 | | Glucose-6-Phosphatase Beta3 |
| External Ids: | HGNC: 248611 | Entrez Gene: 925792 | Ensembl: ENSG000001413497 | OMIM: 6110455 | UniProtKB: Q9BUM13 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n408303 n408304 | |
Export aliases for G6PC3 gene to outside databasesPrevious GC identifers: GC17P042623 GC17P039503 GC17P037912
Summaries for G6PC3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for G6PC3: This gene encodes the catalytic subunit of glucose-6-phosphatase (G6Pase). G6Pase is located in the endoplasmicreticulum (ER) and catalyzes the hydrolysis of glucose-6-phosphate to glucose and phosphate in the last step of thegluconeogenic and glycogenolytic pathways. Mutations in this gene result in autosomal recessive severe congenitalneutropenia. Multiple transcript variants have been found for this gene, only one of which is expected to express aprotein.(provided by RefSeq, Sep 2009) UniProtKB/Swiss-Prot: G6PC3_HUMAN, Q9BUM1Function: Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphatetransporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysisand gluconeogenesis. Probably required for normal neutrophil function Gene Wiki entry for G6PC3
|
Genomic Views for G6PC3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the G6PC3 gene promoter: TBP SREBP-1c MyoD SREBP-1b PPAR-gamma1 SREBP-1a Zic1 TFIID PPAR-gamma2 Other transcription factors
Search SABiosciences Chromatin IP Primers for G6PC3
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat G6PC3 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.31 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21.31G6PC3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P042148: view genomic region
(about GC identifiers)
Start:
|
42,148,098 bp from pter |
End:
|
42,153,712 bp from pter |
Size:
|
5,615 bases |
Orientation:
|
plus strand |
ORGUL member locations: Legend (see complete legend)
42148097 42150905 42153712 chr17
|
Proteins for G6PC3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: G6PC3_HUMAN, Q9BUM1 (See
protein sequence)Recommended Name: Glucose-6-phosphatase 3 Size: 346 amino acids; 38735 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Caution: According to PubMed:12370122, it has no hydrolytic activity
Secondary accessions: Q8WU15Explore the universe of human proteins at neXtProt for G6PC3: NX_Q9BUM1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BUM1 3 DME Specific Peptides for G6PC3 (Q9BUM1)
G6PC3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612396.1 ENSEMBL proteins: ENSP00000269097 ENSP00000466821 ENSP00000467624 ENSP00000466983 ENSP00000468677 ENSP00000465111 Reactome Protein details: Q9BUM1 Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005783 | endoplasmic reticulum |
-- | -- | | GO:0005789 | endoplasmic reticulum membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
G6PC3 for ontologies About GeneDecksing
G6PC3 Antibody Products: Assay Products for G6PC3: |
Protein
Domains / Families for G6PC3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
G6PC3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BUM1ProtoNet protein and cluster: Q9BUM1 1 Blocks protein family: IPB000326 PA-phosphatase related phosphoesterase
UniProtKB/Swiss-Prot: G6PC3_HUMAN, Q9BUM1Similarity: Belongs to the glucose-6-phosphatase family |
Function for G6PC3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: G6PC3_HUMAN, Q9BUM1Function: Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphatetransporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysisand gluconeogenesis. Probably required for normal neutrophil functionCatalytic activity: D-glucose 6-phosphate + H(2)O = D-glucose + phosphateEnzyme regulation: Inhibited by vanadateBiophysicochemical properties: Kinetic parameters: KM=1.0 mM for glucose-6-phosphate (at pH 5.5); KM=2.0 mM forglucose-6-phosphate (at pH 6.5); Note=8 times less active compared to G6PC under the same experimental conditions;Enzyme Number (IUBMB): EC 3.1.3.91 2
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for G6PC3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for G6PC3 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: G6PC3 (NM_138387) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for G6PC3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat G6PC3  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for G6PC3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004346 | glucose-6-phosphatase activity |
IEA | -- |
G6PC3 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for G6PC3: Animal Models: Mouse knock-outs for G6PC3: G6pc3tm1Jyc G6pc3tm1Rmob G6pc3tm1Lex 6 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for G6pc3):
G6PC3 for phenotypes About GeneDecksing
|
Pathways & Interactions for G6PC3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | SLC-mediated transmembrane transport | | | 2 | Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus | | | 3 | Metabolism | | | 4 | MPS IIIC - Sanfilippo syndrome C | |
Pathway sources See GeneCards unified pathways Show all pathways
5/6
Reactome Pathways for G6PC3 (see all 6)
UniProtKB/Swiss-Prot: G6PC3_HUMAN, Q9BUM1Pathway: Carbohydrate biosynthesis; gluconeogenesis
G6PC3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for G6PC3
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
G6PC3 for ontologies About GeneDecksing
|
Drugs & Compounds for G6PC3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for G6PC3
2 HMDB Compounds for G6PC3 About this table Search CenterWatch for drugs/clinical trials and news about G6PC3 
|
Transcripts for G6PC3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for G6PC3 gene: NM_138387.3 Unigene Cluster for G6PC3: Glucose 6 phosphatase, catalytic, 3 Hs.294005 [show with all ESTs]Unigene Representative Sequence: AK0914178 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000269097(uc002iey.3 uc002iez.3 uc002iex.3) ENST00000593115 ENST00000588558 ENST00000585361 ENST00000591696 ENST00000585962 ENST00000590639 ENST00000590253
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for G6PC3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for G6PC3 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: G6PC3 (NM_138387) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for G6PC3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat G6PC3  |
Additional cDNA sequence: AK091417.1 BC002494.2 BC021574.1 BC062596.1 NR_028581.1 NR_028582.1 17 DOTS entries: DT.214766 DT.100817498 DT.100817495 DT.100817504 DT.95245069 DT.100817486 DT.100817488 DT.120906481 DT.99939549 DT.100817499 DT.100817490 DT.92046312 DT.92452291 DT.95245003 DT.99926739 DT.100654599 DT.120668865 24/365 AceView cDNA sequences (see all 365): BQ011208 CR617855 BU185102 CR601615 BU849203 CR608514 CA454913 BI918289 BM051653 NM_138387 CR605360 CA489255 BE392626 BE384894 BU151257 BG257985 BQ434608 AI670976 BU196556 CA489327 AL525339 BU187038 AL530093 AI540614 GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for G6PC3 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | |
| SP1: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | - |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for G6PC3
|
Expression for G6PC3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| G6PC3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TTCAGTGCCC
About this image See G6PC3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for G6PC3
SOURCE GeneReport for Unigene cluster: Hs.294005 UniProtKB/Swiss-Prot: G6PC3_HUMAN, Q9BUM1Tissue specificity: Ubiquitously expressed. Highly expressed in skeletal muscle, at intermediate levels in heart,brain, placenta, kidney, colon, thymus, spleen and pancreas. Also detected in testis, prostate, ovary, liver, lung,small intestine and peripheral blood lymphocytes SABiosciences Expression via Pathway-Focused PCR Array including G6PC3:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for G6PC3 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat G6PC3 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat G6PC3 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat G6PC3 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for G6PC3 |
Orthologs for G6PC3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for G6PC3 gene from 6/17 species (see all 17) About this table
ENSEMBL Gene Tree for G6PC3 (if available) TreeFam Gene Tree for G6PC3 (if available)  |
Paralogs for G6PC3 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for G6PC3 gene
- G6PC2 G6PC22
2 SIMAP similar genes for G6PC3 using alignment to 5 protein entries: G6PC3_HUMAN (see all proteins):G6PC G6PC2
G6PC3 for paralogs About GeneDecksing
|
Genomic Variants for G6PC3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 17 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for G6PC3 (42148098 - 42153712 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for G6PC3: -- Human Gene Mutation Database (HGMD): G6PC3
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing G6PC3 |
|
Disorders
/ Diseases for G6PC3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
G6PC3 for disorders About GeneDecksing
OMIM gene information: 611045 OMIM disorders: 612541 UniProtKB/Swiss-Prot: G6PC3_HUMAN, Q9BUM1
Defects in G6PC3 are the cause of neutropenia severe congenital autosomal recessive type 4 (SCN4)[MIM:612541]. Autosomal recessive SCN constitutes a primary immunodeficiency syndrome associated with increasedapoptosis in myeloid cells. Individuals show a paucity of mature neutrophils in peripheral blood and bone marrow anddevelop life-threatening bacterial infections. SCN4 is a severe congenital neutropenia syndrome associated withcardiac and urogenital malformations Defects in G6PC3 are the cause of Dursun syndrome (DURSS) [MIM:612541]. A disease characterized by pulmonaryarterial hypertension, cardiac abnormalities including secundum-type atrial septal defect, intermittent neutropenia,lymphopenia, monocytosis and anemia 14 diseases for G6PC3: About MalaCardssevere congenital neutropenia neutropenia glycogen storage disease type ia glycogen storage disease darsun syndrome myelokathexis myotonia chronic lymphocytic leukemia lymphocytic leukemia lymphopenia hypoglycemia leukemia cholesterol prostatitis 2 diseases from the University of Copenhagen DISEASES database for G6PC3:Neutropenia Glycogen storage disease Human Genome Epidemiology (HuGE) Navigator: G6PC3 (2 documents) Export disorders for G6PC3 gene to outside databases
|
Publications for G6PC3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for G6PC3 gene, integrated from 9 sources (see all 28): (articles sorted by number of sources associating them with G6PC3) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Identification and characterization of a human cDNA and gene encoding a ubiquitously expressed glucose-6-phosphatase catalytic subunit- related protein. (PubMed id 12370122)1, 2, 3, 9 Martin C.C....O'Brien R.M. (2002)
- Identification and characterisation of a new human glucose-6- phosphatase isoform. (PubMed id 12965222)1, 2, 3 Guionie O.... Burchell A. (2003)
- Digenic mutations in severe congenital neutropenia. (PubMed id 20220065)1, 2 Germeshausen M....Welte K. (2010)
- Mutations in the G6PC3 gene cause Dursun syndrome. (PubMed id 20799326)1, 2 Banka S....Dursun A. (2010)
- Severe congenital neutropenia resulting from G6PC3 de ficiency with increased neutrophil CXCR4 expression and myelokathexis. (PubMed id 20616219)1, 2 McDermott D.H....Murphy P.M. (2010)
- A syndrome with congenital neutropenia and mutations in G6PC3. (PubMed id 19118303)1, 2 Boztug K.... Klein C. (2009)
- Phenotypic heterogeneity and evidence of a founder eff ect associated with G6PC3 mutations in patients with severe congenital neutropen ia. (PubMed id 22469094)1 Smith B.N....Gale R.E. (2012)
- Extended spectrum of human glucose-6-phosphatase catal ytic subunit 3 deficiency: novel genotypes and phenotypic variability in severe congenital neutropenia. (PubMed id 22050868)1 Boztug K....Klein C. (2012)
- G6PC3 mutations are associated with a major defect of glycosylation: a novel mechanism for neutrophil dysfunction. (PubMed id 21385794)1 Hayee B....Segal A.W. (2011)
- Homozygosity mapping and whole-exome sequencing to de tect SLC45A2 and G6PC3 mutations in a single patient with oculocutaneous albini sm and neutropenia. (PubMed id 21677667)1 Cullinane A.R....Gahl W.A. (2011)
|
External Searches for G6PC3 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing G6PC3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing G6PC3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing G6PC3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for G6PC3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for G6PC3 gene: Search GeneIP for patents involving G6PC3
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for G6PC3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
| | | | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for G6PC3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for G6PC3 | | OriGene Protein Over-expression Lysate for G6PC3 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for G6PC3 | | OriGene 3'-UTR Clone for G6PC3 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for G6PC3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for G6PC3 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for G6PC3 | | OriGene Custom Protein Services for G6PC3 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat G6PC3 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing G6PC3 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat G6PC3 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat G6PC3 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat G6PC3 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat G6PC3 |
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| | | Search Tocris compounds for G6PC3 |
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| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for G6PC3 |
|  |  |  | | | Search ThermoFisher Antibodies for G6PC3 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat G6PC3 |
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GeneCards Homepage -
Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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