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Aliases for G6PC2 Gene

Aliases for G6PC2 Gene

  • Glucose-6-Phosphatase Catalytic Subunit 2 2 3
  • Glucose-6-Phosphatase, Catalytic, 2 2 3 5
  • Islet-Specific Glucose-6-Phosphatase Catalytic Subunit-Related Protein 3 4
  • G-6-Pase 2 3 4
  • EC 4 63
  • G6Pase 2 3 4
  • IGRP 3 4
  • Islet Specific Glucose 6 Phosphatase Catalytic Subunit Related Protein 2
  • Islet-Specific Glucose-6-Phosphatase-Related Protein 3
  • Islet-Specific G6CP-Related Protein 3

External Ids for G6PC2 Gene

Previous GeneCards Identifiers for G6PC2 Gene

  • GC02P169961
  • GC02P169583
  • GC02P169466
  • GC02P169757
  • GC02P161653

Summaries for G6PC2 Gene

Entrez Gene Summary for G6PC2 Gene

  • This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, allowing the release of glucose into the bloodstream. The family member encoded by this gene is found in pancreatic islets and does not exhibit phosphohydrolase activity, but it is a major target of cell-mediated autoimmunity in diabetes. Several alternatively spliced transcript variants of this gene have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for G6PC2 Gene

G6PC2 (Glucose-6-Phosphatase Catalytic Subunit 2) is a Protein Coding gene. Diseases associated with G6PC2 include Diabetes Mellitus, Insulin-Dependent. Among its related pathways are Glycosaminoglycan metabolism and Glucagon signaling pathway. GO annotations related to this gene include glucose-6-phosphatase activity. An important paralog of this gene is G6PC.

UniProtKB/Swiss-Prot for G6PC2 Gene

  • May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity).

Gene Wiki entry for G6PC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for G6PC2 Gene

Genomics for G6PC2 Gene

Regulatory Elements for G6PC2 Gene

Enhancers for G6PC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around G6PC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for G6PC2 Gene

168,901,240 bp from pter
168,910,000 bp from pter
8,761 bases
Plus strand

Genomic View for G6PC2 Gene

Genes around G6PC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
G6PC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for G6PC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for G6PC2 Gene

Proteins for G6PC2 Gene

  • Protein details for G6PC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glucose-6-phosphatase 2
    Protein Accession:
    Secondary Accessions:
    • E9PAX2
    • Q6AHZ0

    Protein attributes for G6PC2 Gene

    355 amino acids
    Molecular mass:
    40580 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for G6PC2 Gene


neXtProt entry for G6PC2 Gene

Proteomics data for G6PC2 Gene at MOPED

Selected DME Specific Peptides for G6PC2 Gene

Post-translational modifications for G6PC2 Gene

  • N-glycosylated; the non-glycosylated form is more unstable and is degraded through the proteasome.
  • Glycosylation at Asn 92
  • Modification sites at PhosphoSitePlus

Other Protein References for G6PC2 Gene

Domains & Families for G6PC2 Gene

Gene Families for G6PC2 Gene

Protein Domains for G6PC2 Gene

Suggested Antigen Peptide Sequences for G6PC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glucose-6-phosphatase family.
  • Belongs to the glucose-6-phosphatase family.
genes like me logo Genes that share domains with G6PC2: view

Function for G6PC2 Gene

Molecular function for G6PC2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.45 mM for glucose-6-phosphate (at pH 6.5);
UniProtKB/Swiss-Prot CatalyticActivity:
D-glucose 6-phosphate + H(2)O = D-glucose + phosphate.
UniProtKB/Swiss-Prot Function:
May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity).

Enzyme Numbers (IUBMB) for G6PC2 Gene

genes like me logo Genes that share phenotypes with G6PC2: view

Animal Models for G6PC2 Gene

MGI Knock Outs for G6PC2:

Animal Model Products

CRISPR Products

miRNA for G6PC2 Gene

miRTarBase miRNAs that target G6PC2

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for G6PC2 Gene

Localization for G6PC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for G6PC2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for G6PC2 Gene COMPARTMENTS Subcellular localization image for G6PC2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytosol 1

Gene Ontology (GO) - Cellular Components for G6PC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0030176 integral component of endoplasmic reticulum membrane IBA --
genes like me logo Genes that share ontologies with G6PC2: view

Pathways & Interactions for G6PC2 Gene

genes like me logo Genes that share pathways with G6PC2: view

UniProtKB/Swiss-Prot Q9NQR9-G6PC2_HUMAN

  • Pathway: Carbohydrate biosynthesis; gluconeogenesis.

Interacting Proteins for G6PC2 Gene

Gene Ontology (GO) - Biological Process for G6PC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006094 gluconeogenesis IEA --
GO:0008645 hexose transport TAS --
GO:0015758 glucose transport TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with G6PC2: view

No data available for SIGNOR curated interactions for G6PC2 Gene

Drugs & Compounds for G6PC2 Gene

(1) Drugs for G6PC2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glucose 6-phosphate Experimental Pharma 0

(6) Additional Compounds for G6PC2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • a-D-Glucopyranose
  • a-D-Glucose
  • a-Dextrose
  • a-Glucose
  • alpha-D-Glucopyranose
  • Roferose ST
  • (+)-Glucose
  • Anhydrous dextrose
  • Cerelose
  • Cerelose 2001
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with G6PC2: view

Transcripts for G6PC2 Gene

Unigene Clusters for G6PC2 Gene

Glucose-6-phosphatase, catalytic, 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for G6PC2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d
SP1: - - -
SP2: - -
SP3: - - - - -

Relevant External Links for G6PC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for G6PC2 Gene

mRNA expression in normal human tissues for G6PC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for G6PC2 Gene

This gene is overexpressed in Pancreas (x44.3).

SOURCE GeneReport for Unigene cluster for G6PC2 Gene Hs.283963

mRNA Expression by UniProt/SwissProt for G6PC2 Gene

Tissue specificity: Specifically expressed in pancreas and also detected to a lower extent in testis. Expressed by most islet cells in the pancreas (at protein level).
genes like me logo Genes that share expression patterns with G6PC2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for G6PC2 Gene

Orthologs for G6PC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for G6PC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia G6PC2 35
  • 89.14 (n)
  • 89.52 (a)
G6PC2 36
  • 89 (a)
(Canis familiaris)
Mammalia G6PC2 35
  • 90.75 (n)
  • 89.8 (a)
G6PC2 36
  • 88 (a)
(Mus musculus)
Mammalia G6pc2 35
  • 84.79 (n)
  • 84.23 (a)
G6pc2 16
G6pc2 36
  • 84 (a)
(Pan troglodytes)
Mammalia G6PC2 35
  • 99.15 (n)
  • 98.59 (a)
G6PC2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC681817 35
  • 77.47 (n)
  • 72.78 (a)
(Ornithorhynchus anatinus)
Mammalia G6PC2 36
  • 82 (a)
(Gallus gallus)
Aves G6PC2 35
  • 75.26 (n)
  • 77.9 (a)
G6PC2 36
  • 77 (a)
(Anolis carolinensis)
Reptilia G6PC2 36
  • 72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15400 36
  • 23 (a)
Species with no ortholog for G6PC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for G6PC2 Gene

Gene Tree for G6PC2 (if available)
Gene Tree for G6PC2 (if available)

Paralogs for G6PC2 Gene

Paralogs for G6PC2 Gene

(2) SIMAP similar genes for G6PC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with G6PC2: view

Variants for G6PC2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for G6PC2 Gene

Genetic variations in G6PC2 define the fasting plasma glucose levels quantitative trait locus 1 (FGQTL1) [MIM:612108]. The normal fasting plasma glucose level in the plasma is defined as less than 100 mg per deciliter (5.55 mmol per liter). Higher fasting plasma glucose levels predict type 2 diabetes in young adults and increases the risk of mortality.

Sequence variations from dbSNP and Humsavar for G6PC2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_043372 -
VAR_043373 -
VAR_043374 -
VAR_043375 -
VAR_043376 -

Structural Variations from Database of Genomic Variants (DGV) for G6PC2 Gene

Variant ID Type Subtype PubMed ID
nsv459943 CNV Loss 19166990

Variation tolerance for G6PC2 Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.42; 95.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for G6PC2 Gene

Human Gene Mutation Database (HGMD)

Disorders for G6PC2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for G6PC2 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
diabetes mellitus, insulin-dependent
  • diabetes, type 1
- elite association - COSMIC cancer census association via MalaCards
Search G6PC2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for G6PC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with G6PC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for G6PC2 Gene

Publications for G6PC2 Gene

  1. A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. (PMID: 18451265) Bouatia-Naji N. … Froguel P. (Science 2008) 3 4 23 48 67
  2. A single-nucleotide polymorphism in a methylatable Foxa2 binding site of the G6PC2 promoter is associated with insulin secretion in vivo and increased promoter activity in vitro. (PMID: 18984742) Dos Santos C. … Fradin D. (Diabetes 2009) 3 23
  3. Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk. (PMID: 19533084) Reiling E. … 't Hart L.M. (Diabetologia 2009) 3 23
  4. Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose. (PMID: 19741163) Li X. … Watanabe R.M. (Diabetes 2009) 3 23
  5. Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. (PMID: 18521185) Chen W.M. … Watanabe R.M. (J. Clin. Invest. 2008) 3 23

Products for G6PC2 Gene

Sources for G6PC2 Gene