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G6PC2 Gene

protein-coding GIFtS: 51

GC02P169466

glucose-6-phosphatase, catalytic, 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
EC 3.1.3.9 ^³
IGRP ^¹, ², ³, ⁵
MGC141936 ^²

Descriptions
G-6-Pase 2 ^³
G6Pase 2 ^³
Islet-specific glucose-6-phosphatase catalytic subunit-related protein ^², ³
glucose-6-phosphatase, catalytic, 2 ^²
islet-specific G6CP-related protein ^²
islet-specific glucose-6-phosphatase-related protein ^²

External Ids
HGNC: 28906¹
Entrez Gene: 57818²
UniProtKB: Q9NQR9³
Ensembl: ENSG00000152254⁷

Search outside databases for aliases for G6PC2 gene

Previous GC identifers: GC02P169961 GC02P169583

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for G6PC2:

This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These

enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of

glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, allowing the

release of glucose into the bloodstream. The family member encoded by this gene is found in

pancreatic islets and does not exhibit phosphohydrolase activity, but it is a major target of

cell-mediated autoimmunity in diabetes. Several alternatively spliced transcript variants of this

gene have been described, but their biological validity has not been determined. [provided by

RefSeq]

UniProtKB/Swiss-Prot: G6PC2_HUMAN, Q9NQR9

Function: May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be

responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity)

Gene Wiki entry for G6PC2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the G6PC2 gene

Entrez Gene cytogenetic band: 2q24.3 Ensembl cytogenetic band: 2q24.3 HGNC cytogenetic band: 2q24-q31

G6PC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P169466: (about GC identifiers)

Start:	169,465,996 bp from pter
End:	169,474,756 bp from pter
Size:	8,761 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_005403.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: G6PC2_HUMAN, Q9NQR9 (See protein sequence)

Recommended Name: Glucose-6-phosphatase 2

Size: 355 amino acids; 40580 Da

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein

Secondary accessions: Q6AHZ0

Alternative splicing: 2 isoforms: Q9NQR9-1 Q9NQR9-2

Post-translational modifications:

N-glycosylated; the non-glycosylated form is more unstable and is degraded through the proteasome¹

REFSEQ proteins (2 alternative transcripts):

NP_001075155.1 NP_066999.1

ENSEMBL proteins:

ENSP00000364512 ENSP00000282075

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IGRP)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for G6PC2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (IGRP), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for G6PC2

Assays for G6PC2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9NQR9

ProtoNet protein and cluster: Q9NQR9

1 Blocks protein family: IPB000326 PA-phosphatase related phosphoesterase

UniProtKB/Swiss-Prot: G6PC2_HUMAN, Q9NQR9

Similarity: Belongs to the glucose-6-phosphatase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (G6PC2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001081686

Applied Biosystems Silencer® siRNAs for G6PC2

Sigma-Aldrich siRNA and siRNA Panels for G6PC2

Sigma-Aldrich shRNA for G6PC2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001081686
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001081686
untagged cDNA clones in CMV expression vector (see all 2): NM_001081686

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_021176

UniProtKB/Swiss-Prot: G6PC2_HUMAN, Q9NQR9

Function: May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be

responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity)

Catalytic activity: D-glucose 6-phosphate + H(2)O = D-glucose + phosphate

Biophysicochemical properties: Kinetic parameters: KM=0.45 mM for glucose-6-phosphate (at pH 6.5);

Enzyme Number (IUBMB): EC 3.1.3.9

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for G6pc2):

behavior/neurological

endocrine/exocrine gland

homeostasis/metabolism

reproductive system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004346	glucose-6-phosphatase activity	IEA	--
GO:0016787	hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for G6PC2 (Your Favorite Gene powered by Ingenuity)

Glycolysis/Gluconeogenesis
FXR/RXR Activation
Starch and Sucrose Metabolism
Estrogen Receptor Signaling
Galactose Metabolism

GeneDecks G6PC2 for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: G6PC2_HUMAN, Q9NQR9

Pathway: Carbohydrate biosynthesis; gluconeogenesis

5/7 Interacting proteins for G6PC2 (ENSP00000282075³) via UniProtKB, MINT, and/or STRING (see all 7 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PDX1	ENSP00000370421³	STRING (score=.936)
FOXA2	ENSP00000366319³	STRING (score=.921)
PAX6	ENSP00000368424³	STRING (score=.894)
ENSG00000206394	ENSP00000372897³	STRING (score=.848)
SLC37A4	ENSP00000339048³	STRING (score=.816)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006094	gluconeogenesis	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for G6PC2
1 Novoseek chemical compound relationship for G6PC2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glucose	18.59	18	18753309 (3), 18451265 (3), 17265032 (2), 18984742 (2) (see all 5)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (G6PC2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001081686

Sigma-Aldrich siRNA and siRNA Panels for G6PC2

Sigma-Aldrich shRNA for G6PC2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001081686 NM_021176

REFSEQ mRNAs for G6PC2 gene (2 alternative transcripts):

NM_001081686.1 NM_021176.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001081686 NM_021176

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001081686
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001081686
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001081686

Additional cDNA sequence:

AK310853.1 BC104778.1 BC113376.1 CR627438.1

3 DOTS entries:

DT.40278606 DT.40219081 DT.99956306

24/50 AceView cDNA sequences (see all 50 ):

BQ086257 BM312191 BI438871 BQ548997 BU078726 NM_021176 BI467287 BQ267329

BU074138 BX499266 BQ777188 BI439199 BQ268961 BU579427 BI438359 CR627438

BU786441 BM128741 BM510248 CA771858 BM129145 BQ272569 BX499265 CA773435

highest scoring ESTs for G6PC2:

AL711489 BI438359 BM128001 BX499265 CA772726 BM510248 BQ267329 BQ268961 BQ777188 BU787823

Unigene Cluster for G6PC2:

Glucose-6-phosphatase, catalytic, 2

Hs.283963 [show with all ESTs]

Unigene Representative Sequence: NM_021176

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for G6PC2

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d
SP1:							-				-		-
SP2:							-				-
SP3:					-		-		-		-		-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for G6PC2

2 Ensembl transcripts including schematic representations:

ENST00000375363 ENST00000282075

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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G6PC2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for G6PC2

¹ / ² / ³

2 probe-sets matching G6PC2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
221453_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_021176	0.60	1.00	0.82	1
221453_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTCCAACCCA

SOURCE GeneReport for Unigene cluster: Hs.283963
UniProtKB/Swiss-Prot: G6PC2_HUMAN, Q9NQR9
Tissue specificity: Specifically expressed in pancreas and also detected to a lower extent in
testis. Expressed by most islet cells in the pancreas (at protein level)

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for G6PC2 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	G6PC2¹	--	glucose-6-phosphatase, catalytic, 2	91.03(n) 90.08(a)	488389 XM_545511.2 XP_545511.2
chimpanzee (Pan troglodytes)	G6PC2¹	--	glucose-6-phosphatase, catalytic, 2	99.15(n) 98.59(a)	741431 XM_001155854.1 XP_001155854.1
cow (Bos taurus)	G6PC2¹	--	glucose-6-phosphatase, catalytic, 2	89.14(n) 89.52(a)	505012 XM_581235.3 XP_581235.1
mouse (Mus musculus)	G6pc2^{1, 5}	2 (42.00 cM)⁵	glucose-6-phosphatase, catalytic, 2^{1, 5}	84.79(n)¹ 84.23(a)¹	14378¹ NM_021331.3¹ NP_067306.1¹ AF118761⁵ AF118762⁵ (see all 17)
chicken (Gallus gallus)	G6PC2¹	--	glucose-6-phosphatase, catalytic, 2	74.97(n) 77.44(a)	424171 XM_422017.2 XP_422017.1

About this table Species with no ortholog for G6PC2

ENSEMBL Gene Tree for G6PC2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for G6PC2 gene

G6PC3² G6PC²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/89 NCBI SNPs in G6PC2 are shown (see all 89 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 104)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs517413^1,2	A,C,F,H,O	169464354(+)	`TTTAAT/GTGGAA`	2	--	ng5¹ tfbs³		7	NA EU EA WA	542
	rs573225^1,2	A,C,F,H,O	169465787(-)	`GTTTGC/TTTGAA`	2	--	ng5¹		12	EA NA EU WA	1054
	rs492594^1,2	A,C,F,H,O	169472422(-)	`GCCAAC/GTGCAA`	2	V/L	mis¹ ut3¹ ese³		18	MN NA EA EU WA	2960
	rs2232328^1,2	A,C,F,H,O	169472792(+)	`CTACTC/GTGTTC`	2	S/C	mis¹ ut3¹ ese³		12	EA EU WA NA	2470
	rs540524^1,2	A,C,F,H,O	169465176(-)	`GACTAT/CGACTA`	2	--	ng5¹		11	NA EU EA WA	980
	rs2232316^1,2	C,F,H,O	169465808(+)	`TGTTCG/ACACAA`	2	--	ng5¹		12	EA NA EU WA	1052
--	rs570876^1,2	A,C,F,H	169473623(-)	`aaaaaT/Aattca`	2	--	ut3¹ ese³		4	EU EA WA	412
	rs567243^1,2	A,C,F,H	169473983(-)	`TGTTGT/CCCCTG`	2	--	ut3¹ ese³		9	EA NA EU WA	702
	rs16856141^1,2	C,F,H	169464948(+)	`ACAAAA/GTAACA`	2	--	ng5¹		11	NA EU EA WA	966
	rs2232326^1,2	C,F,H	169472737(+)	`TGCTGT/CCTTTT`	2	P/S	mis¹ ut3¹		8	EU EA WA	838

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HapMap Linkage Disequilibrium images for G6PC2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608058 disorders: 612108

UniProtKB/Swiss-Prot: G6PC2_HUMAN, Q9NQR9

Genetic variation in G6PC2 is associated with fasting plasma glucose levels quantitative

trait locus type 1 (FGQTL1) [MIM:612108]. The normal fasting plasma glucose level in the plasma is

defined as less than 100 mg per deciliter (5.55 mmol per liter). Higher fasting plasma glucose

levels predict type 2 diabetes in young adults and increases the risk of mortality

1 Novoseek disease relationship for G6PC2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
diabetes autoimmune	67.40	2	16012821 (1)

About this table

Human Genome Epidemiology Navigator: G6PC2 (8 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/38 PubMed articles for G6PC2 gene (see all 38 ):

Alternative splicing of G6PC2, the gene coding for the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), results in differential expression in human thymus and spleen compared with pancreas. (PubMed id 16520917)^{1, 3, 4} Dogra R.S....Pugliese A. (2006)
Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes. (PubMed id 11297555)^{1, 3, 4} Martin C.C.... Hutton J.C. (2001)
A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. (PubMed id 18451265)^{1, 3, 4} Bouatia-Naji N....Froguel P. (2008)
The islet-specific glucose-6-phosphatase-related protein, implicated in diabetes, is a glycoprotein embedded in the endoplasmic reticulum membrane. (PubMed id 15044018)^{1, 3, 4} Shieh J.-J.... Chou J.Y. (2004)
Enzymatic characterization of the pancreatic islet-specific glucose- 6-phosphatase-related protein (IGRP). (PubMed id 14722102)^{3, 4} Petrolonis A.J.... Hong S.-B. (2004)
Structure and promoter activity of an islet-specific glucose-6-phosphatase catalytic subunit-related gene. (PubMed id 10078554)^{2, 3} Ebert D.H....O'Brien R.M. (1999)
Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein. (PubMed id 10078553)^{2, 3} Arden S.D....Hutton J.C. (1999)
Foxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression. (PubMed id 18753309)^{1, 3} Martin C.C....O'Brien R.M. (2008)
In islet-specific glucose-6-phosphatase-related protein, the beta cell antigenic sequence that is targeted in diabetes is not responsible for the loss of phosphohydrolase activity. (PubMed id 16012821)^{1, 3} Shieh J.J....Chou J.Y. (2005)
An SNP in a methylatable Foxa2 binding site of the G6PC2 promoter is associated with insulin secretion in vivo and increased promoter activity in vitro. (PubMed id 18984742)^{1, 3} Dos Santos C....Fradin D. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 57818	HGNC: 28906	AceView: G6PC2	Ensembl:ENSG00000152254	euGenes: HUgn57818
ECgene: G6PC2	H-InvDB: G6PC2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for G6PC2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for G6PC2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for G6PC2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for G6PC2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for G6PC2		Browse small molecules at Sigma-Aldrich
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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G6PC2 Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for G6PC2

Summaries
for G6PC2

Genomic Location
for G6PC2

Proteins
for G6PC2

Protein Domains/
Families
for G6PC2

Gene Function
for G6PC2

Pathways & Interactions
for G6PC2

Drugs & Compounds
for G6PC2

Transcripts
for G6PC2

Expression
for G6PC2

Orthologs
for G6PC2

Paralogs
for G6PC2

SNPs/Variants
for G6PC2

Disorders & Mutations
for G6PC2

Medical News
for G6PC2

Publications
for G6PC2

Search for G6PC2

Genome Databases showing G6PC2

Other Databases showing G6PC2

Specialized Databases showing G6PC2

Licensable Technologies
for G6PC2

Services
for G6PC2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

G6PC2 Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor G6PC2

Summariesfor G6PC2

Genomic Locationfor G6PC2

Proteinsfor G6PC2

Protein Domains/Familiesfor G6PC2

Gene Functionfor G6PC2

Pathways & Interactionsfor G6PC2

Drugs & Compoundsfor G6PC2

Transcriptsfor G6PC2

Expression for G6PC2

Orthologsfor G6PC2

Paralogsfor G6PC2

SNPs/Variantsfor G6PC2

Disorders & Mutationsfor G6PC2

Medical Newsfor G6PC2

Publicationsfor G6PC2

Search for G6PC2

Genome Databases showing G6PC2

Other Databases showing G6PC2

Specialized Databases showing G6PC2

Licensable Technologiesfor G6PC2

Servicesfor G6PC2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for G6PC2

Summaries
for G6PC2

Genomic Location
for G6PC2

Proteins
for G6PC2

Protein Domains/
Families
for G6PC2

Gene Function
for G6PC2

Pathways & Interactions
for G6PC2

Drugs & Compounds
for G6PC2

Transcripts
for G6PC2

Expression
for G6PC2

Orthologs
for G6PC2

Paralogs
for G6PC2

SNPs/Variants
for G6PC2

Disorders & Mutations
for G6PC2

Medical News
for G6PC2

Publications
for G6PC2

Licensable Technologies
for G6PC2

Services
for G6PC2