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G6PC Gene

protein-coding GIFtS: 60

GC17P038306

glucose-6-phosphatase, catalytic subunit
(Previous names: glucose-6-phosphatase, catalytic (glycogen storage disease type I, von Gierke disease) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: G6PT)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
EC 3.1.3.9 ^³
G-6-Pase ^³
G6PT ^², ³, ⁵
G6Pase ^³
G6Pase-alpha ^³
GSD1 ^²
GSD1a ^¹, ²
MGC163350 ^²

Descriptions
Glucose-6-phosphatase alpha ^³
glucose-6-phosphatase, catalytic (glycogen storage disease type I, von Gierke disease) ^¹
glucose-6-phosphatase, catalytic subunit ^²

External Ids
HGNC: 4056¹
Entrez Gene: 2538²
UniProtKB: P35575³
Ensembl: ENSG00000131482⁷

Search outside databases for aliases for G6PC gene

Previous GC identifers: GC17M040566 GC17P043214 GC17P040961 GC17P041425

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for G6PC:

Glucose-6-phosphatase is an integral membrane protein of the endoplasmic reticulum that catalyzes

the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate. It is a key enzyme in

glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Defects in the enzyme

cause glycogen storage disease type I (von Gierke disease). [provided by RefSeq]

UniProtKB/Swiss-Prot: G6PC_HUMAN, P35575

Function: Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the

glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production

through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation

of blood glucose levels

Gene Wiki entry for G6PC

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the G6PC gene

Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21

G6PC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P038306: (about GC identifiers)

Start:	38,306,341 bp from pter
End:	38,318,912 bp from pter
Size:	12,572 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010755.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: G6PC_HUMAN, P35575 (See protein sequence)

Recommended Name: Glucose-6-phosphatase

Size: 357 amino acids; 40484 Da

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein

Secondary accessions: A1L4C0

REFSEQ proteins: NP_000142.1

ENSEMBL proteins:

ENSP00000253801

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (glucose-6-phosphatase, catalytic subunit)
	Human Recombinant Proteins from Abnova (G6PC)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005792	microsome	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IDA	10318794

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Antibodies for G6PC:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (glucose-6-phosphatase, catalytic subunit), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for G6PC

Assays for G6PC:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P35575

ProtoNet protein and cluster: P35575

1 Blocks protein family: IPB000326 PA-phosphatase related phosphoesterase

UniProtKB/Swiss-Prot: G6PC_HUMAN, P35575

Similarity: Belongs to the glucose-6-phosphatase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (G6PC)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (G6PC)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000151

Applied Biosystems Silencer® siRNAs for G6PC

Sigma-Aldrich siRNA and siRNA Panels for G6PC

Sigma-Aldrich shRNA for G6PC

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for G6PC
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000151
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000151
untagged cDNA clone in CMV expression vector: NM_000151

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000151

UniProtKB/Swiss-Prot: G6PC_HUMAN, P35575

Function: Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the

glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production

through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation

of blood glucose levels

Catalytic activity: D-glucose 6-phosphate + H(2)O = D-glucose + phosphate

Enzyme Number (IUBMB): EC 3.1.3.9

Genatlas biochemistry entry for G6PC:

glucose-6-phosphatase,catalytic gluconeogenesis,energy pathway

9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for G6pc):

behavior/neurological	growth/size	homeostasis/metabolism	life span-post-weaning/aging	limbs/digits/tail
liver/biliary system	nervous system	renal/urinary system	skeleton

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004346	glucose-6-phosphatase activity	IDA	8211187 10318794
GO:0016773	phosphotransferase activity, alcohol group as acceptor	IEA	--
GO:0016787	hydrolase activity	IEA	--
GO:0042301	phosphate binding	IMP	12093795

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/9 Sigma-Aldrich "Your Favorite Gene" Pathways for G6PC (Your Favorite Gene powered by Ingenuity) (see all 9 )

Starch and Sucrose Metabolism
PXR/RXR Activation
TR/RXR Activation
Estrogen Receptor Signaling
Inositol Phosphate Metabolism

GeneDecks G6PC for the pathways selected above

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UniProtKB/Swiss-Prot: G6PC_HUMAN, P35575

Pathway: Carbohydrate biosynthesis; gluconeogenesis

5/71 Interacting proteins for G6PC (ENSP00000253801³) via UniProtKB, MINT, and/or STRING (see all 71 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FOXO1	ENSP00000368880³	STRING (score=.992)
SLC37A4	ENSP00000339048³	STRING (score=.991)
INS	ENSP00000370731³	STRING (score=.988)
HNF1A	ENSP00000257555³	STRING (score=.962)
GCK	ENSP00000223366³	STRING (score=.946)

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5/13 Gene Ontology (GO) biological process terms (links to tree view) (see all 13 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005980	glycogen catabolic process	IEA	--
GO:0006094	gluconeogenesis	IMP	8211187
GO:0006641	triglyceride metabolic process	IEA	--
GO:0008202	steroid metabolic process	IEA	--
GO:0010468	regulation of gene expression	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for G6PC
10/52 Novoseek chemical compound relationships for G6PC gene (see all 52 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glucose 6-phosphate	88.81	188	18337460 (5), 11899241 (4), 10940311 (3), 11949931 (3) (see all 88)
glycogen	87.92	188	10643970 (4), 7744838 (3), 11739393 (2), 9001800 (2) (see all 99)
phosphoenolpyruvate	80.22	54	15047713 (2), 17211624 (2), 12570714 (1), 12914928 (1) (see all 40)
glucose	73.94	555	8574017 (6), 10960473 (6), 2168325 (5), 9270716 (5) (see all 99)
2-deoxy-d-glucose 6-phosphate	70.47	1	8772513 (1)
pyrophosphate	63.62	9	8605568 (1), 11386847 (1), 8385243 (1), 1311177 (1) (see all 6)
fructose-6-phosphate	58.19	1	7733279 (1)
mannose 6-phosphate	56.81	10	8611029 (2), 7646448 (1), 16452245 (1), 1846754 (1) (see all 6)
acadesine	49.00	2	10866040 (1), 11359348 (1)
fructose	47.65	12	15047713 (2), 8623151 (1), 16046162 (1), 15544551 (1) (see all 10)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (G6PC)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (G6PC)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000151

Sigma-Aldrich siRNA and siRNA Panels for G6PC

Sigma-Aldrich shRNA for G6PC

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000151

REFSEQ mRNAs for G6PC gene:

NM_000151.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000151

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000151
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000151
                                 untagged cDNA clone in CMV expression vector: NM_000151

Additional cDNA sequence:

AK303771.1 AK313982.1 BC130478.1 BC136369.1 U01120.1

3 DOTS entries:

DT.110428 DT.97859344 DT.91651868

24 AceView cDNA sequences:

AA862953 NM_000151 AV656553 U01120 BX110477 AW304142 BX496236 AI672173

H77746 AW614228 BX496198 BG569143 AV694195 CB162421 R02471 BX495293

AV686772 AV697108 AW611950 AV684739 AW337736 AI245594 R02365 AI244022

highest scoring ESTs for G6PC:

U01120 AI245594 AI672173 AW304142 AW337736 BX110477 BX496198 R02365 R02471 AA862953

Unigene Cluster for G6PC:

Glucose-6-phosphatase, catalytic subunit

Hs.212293 [show with all ESTs]

Unigene Representative Sequence: NM_000151

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000253801

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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G6PC expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for G6PC

¹ / ² / ³

4 probe-sets matching G6PC gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36241_r_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U01120	1.00	1.00	1.00	1
206952_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000151	0.60	1.00	0.82	1
206952_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555612_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks G6PC for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.212293
Expression variation in blood from EXPOLDB for G6PC

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for G6PC gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	G6PC¹	--	glucose-6-phosphatase, catalytic subunit	89.54(n) 91.32(a)	403492 XM_850460.1 XP_855553.1
cow (Bos taurus)	G6PC¹	--	glucose-6-phosphatase, catalytic subunit	88.8(n) 92.44(a)	538710 NM_001076124.1 NP_001069592.1
rat (Rattus norvegicus)	G6pc¹	--	glucose-6-phosphatase, catalytic subunit	84.14(n) 86.69(a)	25634 NM_013098.1 NP_037230.1
mouse (Mus musculus)	G6pc^{1, 5}	11⁵	glucose-6-phosphatase, catalytic^{1, 5}	84.78(n)¹ 88.24(a)¹	14377¹ NM_008061.3¹ NP_032087.2¹ AK050279⁵ AK052656⁵ (see all 10)
zebrafish (Danio rerio)	im:6895556¹	--	im:6895556	66.57(n) 64.12(a)	563180 XM_680269.3 XP_685361.1

About this table Species with no ortholog for G6PC

ENSEMBL Gene Tree for G6PC

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for G6PC gene

G6PC3² G6PC2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/82 NCBI SNPs in G6PC are shown (see all 82 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 36)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7209982^1,2	A,C,F,H	38305006(+)	`GACTAT/CACATT`	1	--	ng5¹		4		EU EA WA	420
--	rs161620^1,2	A,C,F,H	38318263(-)	`tggtaT/Gggtgg`	1	--	ut3¹ ese³		7		EU EA WA NA	516
	rs2229611^1,2	C,F,H,O	38316992(+)	`GTGTTC/TAAAGT`	1	--	ut3¹ ese³		17		MN EU EA WA NA	1500
--	rs691511^1,2	C,F,H	38305645(+)	`ccaggC/Gtgtag`	1	--	ng5¹		10		EA NA EU WA	612
	rs9902963^1,2	A,C	38319057(+)	`GGGAGA/TCTTAA`	1	--	ng3¹		0	--	--	--	--
	rs691547^1,2	F,H	38306067(+)	`CTGGTT/ATCGGG`	1	--	ng5¹		6		EA NA EU WA	460
	rs692180^1,2	A,C	38319064(-)	`GATGCA/TTTTAA`	1	--	ng3¹		0	--	--	--	--
--	rs9905900^1,2	H	38316621(+)	`GCCCAG/TAGGTG`	1	Q/H	mis¹ ese³		4		EU EA WA	418
	rs161628^1,2	C,F,H	38313157(-)	`TAGGTC/TGGCTT`	1	P/P	syn¹ ese³		10		EA NA EU WA	676
	rs161626^1,2	A,C,F,H,O	38313321(-)	`GTTTAT/CCCCTA`	1	--	int¹		7		EU EA WA NA	560

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HapMap Linkage Disequilibrium images for G6PC (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 232200

UniProtKB/Swiss-Prot: G6PC_HUMAN, P35575

Defects in G6PC are the cause of glycogen storage disease type 1A (GSD1A) [MIM:232200];

also known as von Gierke disease. GSD1A is a metabolic disorder characterized by impairment of

terminal steps of glycogenolysis and gluconeogenesis. GSD1 patients manifest a wide range of

clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due

to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia,

hyperlipidemia, and hyperuricemia

10/50 Novoseek disease relationships for G6PC gene (see all 50 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glycogen storage disease	96.21	140	7744838 (3), 11739393 (2), 9001800 (2), 8182131 (2) (see all 91)
glycogen storage disease type i	95.63	44	7632512 (2), 7668282 (1), 7572155 (1), 11560001 (1) (see all 31)
glycogen storage disease type vi	81.02	1	8728790 (1)
lactic acidemia	77.86	5	8949949 (2), 11899241 (1), 12189168 (1)
hyperuricemia	70.07	12	8949949 (2), 10625614 (1), 12713862 (1), 11899241 (1) (see all 7)
fanconi-bickel syndrome	69.65	1	7632512 (1)
hepatomegaly	66.47	10	11899241 (1), 12189168 (1), 12846528 (1), 9259982 (1) (see all 6)
hypoglycemia	60.85	12	8949949 (2), 10625614 (1), 11899241 (1), 17023421 (1) (see all 7)
metabolic disorder	57.58	25	8953636 (1), 8641644 (1), 11386847 (1), 9001800 (1) (see all 15)
glycogen storage disease type iv	52.62	2	8245377 (1)

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GeneTests: G6PC

Glycogen Storage Disease Type I

Human Gene Mutation Database: G6PC
Genetic Association Database: G6PC
Human Genome Epidemiology Navigator: G6PC (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/402 PubMed articles for G6PC gene (see all 402 ):

The catalytic center of glucose-6-phosphatase. HIS176 is the nucleophile forming the phosphohistidine-enzyme intermediate during catalysis. (PubMed id 12093795)^{1, 3, 4} Ghosh A.... Chou J.Y. (2002)
Asparagine-linked oligosaccharides are localized to a luminal hydrophilic loop in human glucose-6-phosphatase. (PubMed id 9705299)^{1, 3, 4} Pan C.J.... Chou J.Y. (1998)
Genetic analysis of the glucose-6-phosphatase mutation of type 1a glycogen storage disease in a Chinese family. (PubMed id 9001800)^{1, 3, 4} Lee W.J.... Lin W.H. (1996)
Genetic basis of glycogen storage disease type 1a: prevalent mutations at the glucose-6-phosphatase locus. (PubMed id 7573034)^{1, 3, 4} Lei K.-J....Chou J.Y. (1995)
Glycogen storage disease type I: diagnosis and phenotype/genotype correlation. (PubMed id 12373566)^{1, 3, 4} Matern D....Chen Y.T. (2002)
Mutation frequencies for glycogen storage disease Ia in the Ashkenazi Jewish population. (PubMed id 15316959)^{1, 3, 6} Ekstein J....Risch N. (2004)
Glycogen storage disease type Ia: molecular diagnosis of 51 Japanese patients and characterization of splicing mutations by analysis of ectopically transcribed mRNA from lymphoblastoid cells. (PubMed id 10748407)^{1, 3, 4} Akanuma J....Narisawa K. (2000)
Glycogen storage disease type Ia: four novel mutations (175delGG, R170X, G266V and V338F) identified. (PubMed id 10094563)^{1, 3, 4} Rake J.P.... Scheffer H. (1999)
Identification of three novel mutations (Q54P, W70X and T108I) in the glucose-6-phosphatase gene of patients with glycogen storage disease type Ia. (PubMed id 10447271)^{1, 3, 4} Trioche P.... Labrune P. (1999)
Characterization of the mutations in the glucose-6-phosphatase gene in Israeli patients with glycogen storage disease type 1a: R83C in six Jews and a novel V166G mutation in a Muslim Arab. (PubMed id 7623438)^{1, 3, 4} Parvari R.... Bashan N. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2538	HGNC: 4056	AceView: G6PC	Ensembl:ENSG00000131482	euGenes: HUgn2538
ECgene: G6PC	H-InvDB: G6PC

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
GeneReviews	http://www.genetests.org/query?gene=G6PC

Licensable Technologies for G6PC
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for G6PC:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for G6PC-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for G6PC		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for G6PC		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (G6PC)
	Search for Antibodies
	Chimera RNAi (G6PC)
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	Recombinant Proteins (glucose-6-phosphatase, catalytic subunit)
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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G6PC Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for G6PC

Summaries
for G6PC

Genomic Location
for G6PC

Proteins
for G6PC

Protein Domains/
Families
for G6PC

Gene Function
for G6PC

Pathways & Interactions
for G6PC

Drugs & Compounds
for G6PC

Transcripts
for G6PC

Expression
for G6PC

Orthologs
for G6PC

Paralogs
for G6PC

SNPs/Variants
for G6PC

Disorders & Mutations
for G6PC

Medical News
for G6PC

Publications
for G6PC

Search for G6PC

Genome Databases showing G6PC

Other Databases showing G6PC

Specialized Databases showing G6PC

Licensable Technologies
for G6PC

Services
for G6PC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

G6PC Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor G6PC

Summariesfor G6PC

Genomic Locationfor G6PC

Proteinsfor G6PC

Protein Domains/Familiesfor G6PC

Gene Functionfor G6PC

Pathways & Interactionsfor G6PC

Drugs & Compoundsfor G6PC

Transcriptsfor G6PC

Expression for G6PC

Orthologsfor G6PC

Paralogsfor G6PC

SNPs/Variantsfor G6PC

Disorders & Mutationsfor G6PC

Medical Newsfor G6PC

Publicationsfor G6PC

Search for G6PC

Genome Databases showing G6PC

Other Databases showing G6PC

Specialized Databases showing G6PC

Licensable Technologiesfor G6PC

Servicesfor G6PC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for G6PC

Summaries
for G6PC

Genomic Location
for G6PC

Proteins
for G6PC

Protein Domains/
Families
for G6PC

Gene Function
for G6PC

Pathways & Interactions
for G6PC

Drugs & Compounds
for G6PC

Transcripts
for G6PC

Expression
for G6PC

Orthologs
for G6PC

Paralogs
for G6PC

SNPs/Variants
for G6PC

Disorders & Mutations
for G6PC

Medical News
for G6PC

Publications
for G6PC

Licensable Technologies
for G6PC

Services
for G6PC