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Aliases for G3BP2 Gene

Aliases for G3BP2 Gene

  • G3BP Stress Granule Assembly Factor 2 2 3 5
  • Ras-GTPase Activating Protein SH3 Domain-Binding Protein 2 2 3
  • GTPase Activating Protein (SH3 Domain) Binding Protein 2 2 3
  • GAP SH3 Domain-Binding Protein 2 3 4
  • G3BP-2 3 4
  • Ras GTPase-Activating Protein-Binding Protein 2 3
  • KIAA0660 4

External Ids for G3BP2 Gene

Previous GeneCards Identifiers for G3BP2 Gene

  • GC04M076463
  • GC04M076758
  • GC04M076960
  • GC04M077026
  • GC04M076925
  • GC04M076567
  • GC04M072314

Summaries for G3BP2 Gene

GeneCards Summary for G3BP2 Gene

G3BP2 (G3BP Stress Granule Assembly Factor 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is G3BP1.

UniProtKB/Swiss-Prot for G3BP2 Gene

  • Probable scaffold protein that may be involved in mRNA transport.

Gene Wiki entry for G3BP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for G3BP2 Gene

Genomics for G3BP2 Gene

Regulatory Elements for G3BP2 Gene

Enhancers for G3BP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G075686 1.2 FANTOM5 ENCODE dbSUPER 19.4 +37.8 37774 1.2 CTCF ESRRA BHLHE40 NR3C1 CHAMP1 NR2F2 CBX5 TRIM24 TRIM28 ZXDB G3BP2 USO1 LOC105377284 RNU2-16P CDKL2 RCHY1 ENSG00000201644 GC04M075663
GH04G075701 1.1 ENCODE dbSUPER 18.9 +20.1 20109 5.1 TBP ARID4B DMAP1 RAD21 CREM MIXL1 CEBPB MIER2 PPARG MIER3 G3BP2 USO1 CDKL2 C4orf26 CCDC158 ENSG00000201644 GC04M075663
GH04G075671 1.4 ENCODE dbSUPER 13.2 +51.1 51125 4.4 HDGF PKNOX1 FOXA2 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 YY1 USO1 G3BP2 CDKL2 NAAA ENSG00000201644 GC04M075663
GH04G075654 0.7 dbSUPER 23 +69.2 69216 1.5 SCRT1 PAF1 PKNOX1 ZNF687 SIN3A MNT OSR2 ZNF335 JUND GATA3 G3BP2 CDKL2 USO1 ENSG00000201644 GC04M075663 GC04P075638
GH04G075667 0.6 dbSUPER 24.2 +55.6 55632 1.9 ARID1B NCOR1 HMBOX1 KDM1A PRDM1 FOXA1 G3BP2 USO1 ENSG00000201644 GC04M075663
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around G3BP2 on UCSC Golden Path with GeneCards custom track

Promoters for G3BP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000169417 -375 3001 HDGF FOXA2 CREB3L1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for G3BP2 Gene

Chromosome:
4
Start:
75,642,769 bp from pter
End:
75,724,525 bp from pter
Size:
81,757 bases
Orientation:
Minus strand

Genomic View for G3BP2 Gene

Genes around G3BP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
G3BP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for G3BP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for G3BP2 Gene

Proteins for G3BP2 Gene

  • Protein details for G3BP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UN86-G3BP2_HUMAN
    Recommended name:
    Ras GTPase-activating protein-binding protein 2
    Protein Accession:
    Q9UN86
    Secondary Accessions:
    • A8K6X1
    • O60606
    • O75149
    • Q9UPA1

    Protein attributes for G3BP2 Gene

    Size:
    482 amino acids
    Molecular mass:
    54121 Da
    Quaternary structure:
    • Binds to the N-terminal domain of I-kappa-B-alpha.
    SequenceCaution:
    • Sequence=BAA31635.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for G3BP2 Gene

    Alternative splice isoforms for G3BP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for G3BP2 Gene

Post-translational modifications for G3BP2 Gene

  • Arg-457 and Arg-468 are dimethylated, probably to asymmetric dimethylarginine.
  • Ubiquitination at Lys25, Lys76, isoforms=2107, and isoforms=2370
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for G3BP2 Gene

Domains & Families for G3BP2 Gene

Gene Families for G3BP2 Gene

Suggested Antigen Peptide Sequences for G3BP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with G3BP2: view

No data available for UniProtKB/Swiss-Prot for G3BP2 Gene

Function for G3BP2 Gene

Molecular function for G3BP2 Gene

UniProtKB/Swiss-Prot Function:
Probable scaffold protein that may be involved in mRNA transport.

Gene Ontology (GO) - Molecular Function for G3BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA,IEA 22658674
GO:0003729 mRNA binding IBA --
GO:0005515 protein binding IPI 19615732
GO:0030159 receptor signaling complex scaffold activity NAS 10969074
genes like me logo Genes that share ontologies with G3BP2: view
genes like me logo Genes that share phenotypes with G3BP2: view

Animal Models for G3BP2 Gene

MGI Knock Outs for G3BP2:

Animal Model Products

CRISPR Products

miRNA for G3BP2 Gene

miRTarBase miRNAs that target G3BP2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for G3BP2 Gene

Localization for G3BP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for G3BP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for G3BP2 gene
Compartment Confidence
cytosol 5

Gene Ontology (GO) - Cellular Components for G3BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm NAS 10969074
GO:0005829 cytosol IDA --
GO:0030529 intracellular ribonucleoprotein complex IBA --
genes like me logo Genes that share ontologies with G3BP2: view

Pathways & Interactions for G3BP2 Gene

SuperPathways for G3BP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for G3BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007253 cytoplasmic sequestering of NF-kappaB NAS 10969074
GO:0007265 Ras protein signal transduction NAS 9575347
GO:0034063 stress granule assembly IEA --
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with G3BP2: view

No data available for Pathways by source and SIGNOR curated interactions for G3BP2 Gene

Transcripts for G3BP2 Gene

Unigene Clusters for G3BP2 Gene

GTPase activating protein (SH3 domain) binding protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for G3BP2 Gene

No ASD Table

Relevant External Links for G3BP2 Gene

GeneLoc Exon Structure for
G3BP2
ECgene alternative splicing isoforms for
G3BP2

Expression for G3BP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for G3BP2 Gene

Protein differential expression in normal tissues from HIPED for G3BP2 Gene

This gene is overexpressed in Brain (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for G3BP2 Gene



Protein tissue co-expression partners for G3BP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of G3BP2 Gene:

G3BP2

SOURCE GeneReport for Unigene cluster for G3BP2 Gene:

Hs.303676

Evidence on tissue expression from TISSUES for G3BP2 Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Skin(2.7)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with G3BP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for G3BP2 Gene

Orthologs for G3BP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for G3BP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia G3BP2 34 35
  • 99.79 (n)
cow
(Bos Taurus)
Mammalia G3BP2 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia G3BP2 34 35
  • 96.06 (n)
oppossum
(Monodelphis domestica)
Mammalia G3BP2 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia G3bp2 34 16 35
  • 93.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia G3BP2 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves G3BP2 34 35
  • 81.33 (n)
lizard
(Anolis carolinensis)
Reptilia G3BP2 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia g3bp2 34
  • 76.16 (n)
MGC75649 34
zebrafish
(Danio rerio)
Actinopterygii g3bp2 35
  • 69 (a)
OneToMany
G3BP2 (3 of 3) 35
  • 68 (a)
OneToMany
G3BP2 (2 of 3) 35
  • 65 (a)
OneToMany
zgc:56304 34
  • 64.16 (n)
Dr.5661 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6884 34
fruit fly
(Drosophila melanogaster)
Insecta rin 35
  • 23 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G69250 34
  • 52.42 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10329 35
  • 21 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11520 34
Species where no ortholog for G3BP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for G3BP2 Gene

ENSEMBL:
Gene Tree for G3BP2 (if available)
TreeFam:
Gene Tree for G3BP2 (if available)

Paralogs for G3BP2 Gene

Paralogs for G3BP2 Gene

genes like me logo Genes that share paralogs with G3BP2: view

Variants for G3BP2 Gene

Sequence variations from dbSNP and Humsavar for G3BP2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_036128 A breast cancer sample
rs1000033236 -- 75,700,245(+) GACGG(A/G)GTTTG intron-variant
rs1000059936 -- 75,664,172(+) CCACC(A/G)TGCCC intron-variant, upstream-variant-2KB
rs1000087813 -- 75,657,484(+) CCTAT(C/T)AGAAG intron-variant
rs1000130565 -- 75,705,296(+) GGCTG(C/T)GCCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for G3BP2 Gene

Variant ID Type Subtype PubMed ID
esv2670113 CNV deletion 23128226
esv3308530 CNV mobile element insertion 20981092
esv3424694 CNV insertion 20981092
esv3601033 CNV loss 21293372
nsv1117103 CNV deletion 24896259
nsv7363 OTHER inversion 18451855

Variation tolerance for G3BP2 Gene

Residual Variation Intolerance Score: 13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for G3BP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
G3BP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for G3BP2 Gene

Disorders for G3BP2 Gene

Relevant External Links for G3BP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
G3BP2

No disorders were found for G3BP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for G3BP2 Gene

Publications for G3BP2 Gene

  1. IkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in the cytoplasm through interaction with a novel partner, RasGAP SH3- binding protein 2. (PMID: 10969074) Prigent M. … Dargemont C. (J. Biol. Chem. 2000) 3 4 22 64
  2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 64
  3. PKCI+ binds G3BP2 and regulates stress granule formation following cellular stress. (PMID: 22536444) Kobayashi T. … Larsson C. (PLoS ONE 2012) 2 3 64
  4. Modulation of p53 and MDM2 activity by novel interaction with Ras-GAP binding proteins (G3BP). (PMID: 17297477) Kim M.M. … Yuan Z.M. (Oncogene 2007) 3 22 64
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64

Products for G3BP2 Gene

Sources for G3BP2 Gene

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