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Aliases for G3BP2 Gene

Aliases for G3BP2 Gene

  • G3BP Stress Granule Assembly Factor 2 2 3
  • GTPase Activating Protein (SH3 Domain) Binding Protein 2 2 3 5
  • Ras-GTPase Activating Protein SH3 Domain-Binding Protein 2 2 3
  • GAP SH3 Domain-Binding Protein 2 3 4
  • G3BP-2 3 4
  • KIAA0660 4

External Ids for G3BP2 Gene

Previous GeneCards Identifiers for G3BP2 Gene

  • GC04M076463
  • GC04M076758
  • GC04M076960
  • GC04M077026
  • GC04M076925
  • GC04M076567
  • GC04M072314

Summaries for G3BP2 Gene

GeneCards Summary for G3BP2 Gene

G3BP2 (G3BP Stress Granule Assembly Factor 2) is a Protein Coding gene. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is G3BP1.

UniProtKB/Swiss-Prot for G3BP2 Gene

  • Probable scaffold protein that may be involved in mRNA transport.

Gene Wiki entry for G3BP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for G3BP2 Gene

Genomics for G3BP2 Gene

Regulatory Elements for G3BP2 Gene

Enhancers for G3BP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around G3BP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for G3BP2 Gene

Chromosome:
4
Start:
75,642,769 bp from pter
End:
75,724,525 bp from pter
Size:
81,757 bases
Orientation:
Minus strand

Genomic View for G3BP2 Gene

Genes around G3BP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
G3BP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for G3BP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for G3BP2 Gene

Proteins for G3BP2 Gene

  • Protein details for G3BP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UN86-G3BP2_HUMAN
    Recommended name:
    Ras GTPase-activating protein-binding protein 2
    Protein Accession:
    Q9UN86
    Secondary Accessions:
    • A8K6X1
    • O60606
    • O75149
    • Q9UPA1

    Protein attributes for G3BP2 Gene

    Size:
    482 amino acids
    Molecular mass:
    54121 Da
    Quaternary structure:
    • Binds to the N-terminal domain of I-kappa-B-alpha.
    SequenceCaution:
    • Sequence=BAA31635.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for G3BP2 Gene

    Alternative splice isoforms for G3BP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for G3BP2 Gene

Proteomics data for G3BP2 Gene at MOPED

Post-translational modifications for G3BP2 Gene

  • Arg-457 and Arg-468 are dimethylated, probably to asymmetric dimethylarginine.
  • Ubiquitination at Lys 25, Lys 76, Lys 107, and Lys 370
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for G3BP2 Gene

Domains & Families for G3BP2 Gene

Gene Families for G3BP2 Gene

Suggested Antigen Peptide Sequences for G3BP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UN86

UniProtKB/Swiss-Prot:

G3BP2_HUMAN :
  • Contains 1 NTF2 domain.
Domain:
  • Contains 1 NTF2 domain.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with G3BP2: view

Function for G3BP2 Gene

Molecular function for G3BP2 Gene

UniProtKB/Swiss-Prot Function:
Probable scaffold protein that may be involved in mRNA transport.

Gene Ontology (GO) - Molecular Function for G3BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0030159 receptor signaling complex scaffold activity NAS 10969074
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with G3BP2: view
genes like me logo Genes that share phenotypes with G3BP2: view

Animal Models for G3BP2 Gene

MGI Knock Outs for G3BP2:

Animal Model Products

miRNA for G3BP2 Gene

miRTarBase miRNAs that target G3BP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for G3BP2 Gene

Localization for G3BP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for G3BP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for G3BP2 Gene COMPARTMENTS Subcellular localization image for G3BP2 gene
Compartment Confidence
cytosol 5

Gene Ontology (GO) - Cellular Components for G3BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS,IDA 10969074
genes like me logo Genes that share ontologies with G3BP2: view

Pathways & Interactions for G3BP2 Gene

genes like me logo Genes that share pathways with G3BP2: view

Pathways by source for G3BP2 Gene

1 BioSystems pathway for G3BP2 Gene

Gene Ontology (GO) - Biological Process for G3BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007253 cytoplasmic sequestering of NF-kappaB NAS 10969074
genes like me logo Genes that share ontologies with G3BP2: view

No data available for SIGNOR curated interactions for G3BP2 Gene

Drugs & Compounds for G3BP2 Gene

No Compound Related Data Available

Transcripts for G3BP2 Gene

Unigene Clusters for G3BP2 Gene

GTPase activating protein (SH3 domain) binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for G3BP2 Gene

No ASD Table

Relevant External Links for G3BP2 Gene

GeneLoc Exon Structure for
G3BP2
ECgene alternative splicing isoforms for
G3BP2

Expression for G3BP2 Gene

mRNA expression in normal human tissues for G3BP2 Gene

Protein differential expression in normal tissues from HIPED for G3BP2 Gene

This gene is overexpressed in Brain (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for G3BP2 Gene



SOURCE GeneReport for Unigene cluster for G3BP2 Gene Hs.303676

genes like me logo Genes that share expression patterns with G3BP2: view

Protein tissue co-expression partners for G3BP2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for G3BP2 Gene

Orthologs for G3BP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for G3BP2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia G3BP2 35
  • 96.06 (n)
  • 98.76 (a)
G3BP2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia G3bp2 35
  • 93.22 (n)
  • 98.34 (a)
G3bp2 16
G3bp2 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia G3BP2 35
  • 99.79 (n)
  • 100 (a)
G3BP2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia G3BP2 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia G3BP2 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia G3BP2 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves G3BP2 35
  • 81.33 (n)
  • 93.15 (a)
G3BP2 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia G3BP2 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia g3bp2 35
  • 76.16 (n)
  • 83.78 (a)
MGC75649 35
zebrafish
(Danio rerio)
Actinopterygii Dr.5661 35
zgc:56304 35
  • 64.16 (n)
  • 70.87 (a)
g3bp2 36
  • 69 (a)
OneToMany
G3BP2 (2 of 3) 36
  • 65 (a)
OneToMany
G3BP2 (3 of 3) 36
  • 68 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6884 35
fruit fly
(Drosophila melanogaster)
Insecta rin 36
  • 23 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G69250 35
  • 52.42 (n)
  • 38.46 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11520 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10329 36
  • 21 (a)
OneToOne
Species with no ortholog for G3BP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for G3BP2 Gene

ENSEMBL:
Gene Tree for G3BP2 (if available)
TreeFam:
Gene Tree for G3BP2 (if available)

Paralogs for G3BP2 Gene

Paralogs for G3BP2 Gene

genes like me logo Genes that share paralogs with G3BP2: view

Variants for G3BP2 Gene

Sequence variations from dbSNP and Humsavar for G3BP2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_036128 A breast cancer sample
rs12983 -- 75,644,431(-) AAATC(A/G)TCGAA utr-variant-3-prime
rs884871 -- 75,646,548(-) GGATC(A/G)GGGAG intron-variant
rs1546539 -- 75,685,708(-) TTTAT(A/G)TGGTG intron-variant
rs1548175 -- 75,686,991(-) CTCAG(C/T)CTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for G3BP2 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER Inversion 18451855
nsv879495 CNV Loss 21882294
dgv5637n71 CNV Loss 21882294
esv2670113 CNV Deletion 23128226
esv272803 CNV Insertion 20981092

Variation tolerance for G3BP2 Gene

Residual Variation Intolerance Score: 13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for G3BP2 Gene

HapMap Linkage Disequilibrium report
G3BP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for G3BP2 Gene

Disorders for G3BP2 Gene

Relevant External Links for G3BP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
G3BP2

No disorders were found for G3BP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for G3BP2 Gene

Publications for G3BP2 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. PKCI+ binds G3BP2 and regulates stress granule formation following cellular stress. (PMID: 22536444) Kobayashi T. … Larsson C. (PLoS ONE 2012) 2 3
  3. Modulation of p53 and MDM2 activity by novel interaction with Ras-GAP binding proteins (G3BP). (PMID: 17297477) Kim M.M. … Yuan Z.M. (Oncogene 2007) 3 23
  4. IkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in the cytoplasm through interaction with a novel partner, RasGAP SH3- binding protein 2. (PMID: 10969074) Prigent M. … Dargemont C. (J. Biol. Chem. 2000) 3 23
  5. Identification of a mouse orthologue of the human ras-GAP-SH3-domain binding protein and structural confirmation that these proteins contain an RNA recognition motif. (PMID: 9575347) Kennedy D. … Mattick J.S. (Biomed. Pept. Proteins Nucleic Acids 0) 2 3

Products for G3BP2 Gene

Sources for G3BP2 Gene

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