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Aliases & Descriptions for G3BP2
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases G3BP-2 3 KIAA0660 1 , 3
Descriptions GAP SH3 domain-binding protein 2 3 GTPase activating protein (SH3 domain) binding protein 2 2 Ras-GTPase activating protein SH3 domain-binding protein 2 2
Search outside databases for aliases for G3BP2 genePrevious GC identifers: GC04M076463 GC04M076960 GC04M077026 GC04M076925
Summaries for G3BP2 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: G3BP2_HUMAN, Q9UN86 Function : Probable scaffold protein that may be involved in mRNA transport (Potential)
Gene Wiki entry for G3BP2
Genomic Location for G3BP2
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the G3BP2 gene Entrez Gene cytogenetic band: 4q21.1 Ensembl cytogenetic band: 4q21.1 HGNC cytogenetic band: 4q21.1 G3BP2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04M076758:
(about GC identifiers )
Start:
76,786,990 bp from pter
End:
76,817,629 bp from pter
Size:
30,640 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000004.10 NT_016354.18 Proteins for G3BP2
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: G3BP2_HUMAN, Q9UN86 (See
protein sequence )Recommended Name: Ras GTPase-activating protein-binding protein 2 Size : 482 amino acids; 54121 Da
Subunit : Binds to the N-terminal domain of I-kappa-B-alpha
Subcellular location : Cytoplasm
Secondary accessions : O60606 O75149 Q9UPA1Alternative splicing : 2 isoforms : Q9UN86-1 Q9UN86-2
Post-translational modifications:
Arg-457 and Arg-468 are dimethylated, probably to asymmetric dimethylarginine1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (3 alternative transcripts):
NP_036429.2 NP_987100.1 NP_987101.1 ENSEMBL proteins: ENSP00000352738 ENSP00000350518 ENSP00000379069 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: G3BP2 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for G3BP2: Assays for G3BP2:
Protein
Domains/ Families for G3BP2(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9UN86 ProtoNet protein and cluster: Q9UN86
2 Blocks protein families : IPB000504 RNA-binding region RNP-1 (RNA recognition motif) IPB002075 Nuclear transport factor 2 (NTF2) UniProtKB/Swiss-Prot: G3BP2_HUMAN, Q9UN86 Similarity : Contains 1 NTF2 domainSimilarity : Contains 1 RRM (RNA recognition motif) domain
Gene Function for G3BP2
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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RNAi Products ,
Clones , and
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_203504 Applied Biosystems Silencer ® siRNAs for G3BP2 Sigma-Aldrich siRNA for G3BP2 Sigma-Aldrich shRNA for G3BP2 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_012297                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_012297                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_012297  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_012297 UniProtKB/Swiss-Prot: G3BP2_HUMAN, Q9UN86 Function : Probable scaffold protein that may be involved in mRNA transport (Potential)
4 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for G3BP2
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for G3BP2 5/67 Interacting proteins for G3BP2 (Q9UN86 1 ENSP00000352738 3 ) via UniProtKB, MINT, and/or STRING (see all 67
)About this table 4 Gene Ontology (GO) biological process terms (links to tree view) :
About this table
Drugs & Compounds for G3BP2 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
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Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Transcripts for G3BP2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_203504 Sigma-Aldrich siRNA for G3BP2 Sigma-Aldrich shRNA for G3BP2 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_012297 NM_203504 NM_203505
REFSEQ mRNAs for G3BP2 gene (3 alternative transcripts): NM_012297.4 NM_203504.2 NM_203505.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_012297 NM_203504 NM_203505
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_012297                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_012297                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_012297  
Additional cDNA sequence: AB014560.1 AF051311.1 AF053535.1 AF070615.1 AF145284.1 AK291772.1 AK291786.1 BC011731.2
24/38 DOTS entries (see all 38
): DT.95133911 DT.97785956 DT.454665 DT.100828171 DT.121228664 DT.100722540 DT.121228537 DT.121228679 DT.91825578 DT.102843995 DT.100828168 DT.121228625 DT.100799988 DT.100799597 DT.121228550 DT.91699073 DT.100828176 DT.121228545 DT.121228546 DT.40119218 DT.99961712 DT.100828169 DT.100828174 DT.121228548
24/451 AceView cDNA sequences (see all 451
):AA905408 AI564324 BQ921099 F11785 AA577211 BQ710582 BE676426 BU161990 BU155808 BQ061154 BQ880868 BQ222199 BQ049961 BM478534 CA429088 AA781267 T30867 BU192740 NM_012297 AI581388 BM456585 BF817108 AI863267 CA442944
highest scoring ESTs for G3BP2 :AF053535 AF145284 AL537462 AL710629 AL710930 AU077111 AU280134 BC011731 BF815661 BF975851
Unigene Cluster for G3BP2: GTPase activating protein (SH3 domain) binding protein 2 Hs.303676 [show with all ESTs ] Unigene Representative Sequence: NM_203505 GeneLoc Exon Structure 3 Ensembl transcripts including schematic representations : ENST00000359707
ENST00000357854
ENST00000395719
Expression for G3BP2
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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G3BP2 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for G3BP2 1 / 2 / 3
8 probe-sets matching G3BP2 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GTGATTGTTCSOURCE GeneReport for Unigene cluster: Hs.303676 Expression variation in blood from EXPOLDB for G3BP2
Orthologs for G3BP2
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for G3BP2 gene from 5/11 species (see all 11
)
About this table Species with no ortholog for G3BP2 ENSEMBL Gene Tree for G3BP2 Paralogs for G3BP2 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for G3BP2 gene G3BP1 2
SNPs/Variants for G3BP2 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for G3BP2 (up to first 250kb)
Disorders & Mutations for G3BP2
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
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Blood group antigen gene mutations by BGMUT ,
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--
Medical News for G3BP2 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for G3BP2 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/20 PubMed articles for G3BP2 gene (see all 20
): Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811) 2, 3, 4 Ishikawa K....Ohara O. (1998) IkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in the cytoplasm through interaction with a novel partner, RasGAP SH3- binding protein 2. (PubMed id 10969074) 1, 3, 4 Prigent M.... Dargemont C. (2000) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 3, 4 Olsen J.V....Mann M. (2006) Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. (PubMed id 15782174) 3, 4 Ong S.E.... Mann M. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Identification of a mouse orthologue of the human ras-GAP-SH3-domain binding protein and structural confirmation that these proteins contain an RNA recognition motif. (PubMed id 9575347) 2, 3 Kennedy D....Mattick J.S. (1996-1997) Modulation of p53 and MDM2 activity by novel interaction with Ras-GAP binding proteins (G3BP). (PubMed id 17297477) 1, 3 Kim M.M....Yuan Z.M. (2007) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976) 4 Daub H.... Mann M. (2008) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 4 Dephoure N.... Gygi S.P. (2008) Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147) 3 Wu C....Li S.S. (2007)
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Specialized Databases showing G3BP2 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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