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Aliases for G3BP1 Gene

Aliases for G3BP1 Gene

  • GTPase Activating Protein (SH3 Domain) Binding Protein 1 2 3
  • G3BP 3 4 6
  • Ras-GTPase-Activating Protein SH3-Domain-Binding Protein 2 3
  • GAP SH3 Domain-Binding Protein 1 3 4
  • ATP-Dependent DNA Helicase VIII 3 4
  • G3BP-1 3 4
  • Ras GTPase-Activating Protein-Binding Protein 1 3
  • RasGAP-Associated Endoribonuclease G3BP 3
  • GAP Binding Protein 3
  • EC 3.6.4.12 4
  • EC 3.6.4.13 4
  • HDH-VIII 3
  • HDH VIII 4
  • EC 3.6.1 63

External Ids for G3BP1 Gene

Previous GeneCards Identifiers for G3BP1 Gene

  • GC05P151132
  • GC05P151151
  • GC05P146296

Summaries for G3BP1 Gene

Entrez Gene Summary for G3BP1 Gene

  • This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for G3BP1 Gene

G3BP1 (GTPase Activating Protein (SH3 Domain) Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include mRNA binding and ATP-dependent DNA helicase activity. An important paralog of this gene is G3BP2.

UniProtKB/Swiss-Prot for G3BP1 Gene

  • May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3 tail or hanging tails at both 5- and 3-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5 to 3 direction along the bound single-stranded DNA.

Gene Wiki entry for G3BP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for G3BP1 Gene

Genomics for G3BP1 Gene

Regulatory Elements for G3BP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for G3BP1 Gene

Start:
151,771,045 bp from pter
End:
151,812,785 bp from pter
Size:
41,741 bases
Orientation:
Plus strand

Genomic View for G3BP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for G3BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for G3BP1 Gene

Proteins for G3BP1 Gene

  • Protein details for G3BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13283-G3BP1_HUMAN
    Recommended name:
    Ras GTPase-activating protein-binding protein 1
    Protein Accession:
    Q13283
    Secondary Accessions:
    • Q5HYE9

    Protein attributes for G3BP1 Gene

    Size:
    466 amino acids
    Molecular mass:
    52164 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Mg(2+) is required for helicase activity.;
    Quaternary structure:
    • Binds to the SH3 domain of Ras GTPase-activating protein (RASA1) in proliferating cells. No interaction in quiescent cells Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP1 (By similarity). Interacts with USP10, and may regulate it. Forms homodimers and oligomers. Interacts with RPTOR and SPAG5; this complex is increased by oxidative stress.

    Three dimensional structures from OCA and Proteopedia for G3BP1 Gene

    Alternative splice isoforms for G3BP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for G3BP1 Gene

Proteomics data for G3BP1 Gene at MOPED

Post-translational modifications for G3BP1 Gene

  • Arg-435 is dimethylated, probably to asymmetric dimethylarginine
  • Phosphorylated exclusively on serine residues. Hyperphosphorylated in quiescent fibroblasts. Hypophosphorylation leads to a decrease in endoribonuclease activity (By similarity). RASA1-dependent phosphorylation of Ser-149 induces a conformational change that prevents self-association. Dephosphorylation after HRAS activation is required for stress granule assembly. Ser-149 phosphorylation induces partial nuclear localization.
  • Ubiquitination at Lys5, Lys36, Lys50, Lys59, Lys64, Lys76, Lys123, and Lys376
  • Modification sites at PhosphoSitePlus

Domains for G3BP1 Gene

Gene Families for G3BP1 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Suggested Antigen Peptide Sequences for G3BP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13283

UniProtKB/Swiss-Prot:

G3BP1_HUMAN :
  • Q13283
Domain:
  • The NTF2 domain mediates multimerization
  • Contains 1 NTF2 domain.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with G3BP1: view

Function for G3BP1 Gene

Molecular function for G3BP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3 tail or hanging tails at both 5- and 3-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5 to 3 direction along the bound single-stranded DNA.

Enzyme Numbers (IUBMB) for G3BP1 Gene

Gene Ontology (GO) - Molecular Function for G3BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003729 mRNA binding IEA --
GO:0004003 ATP-dependent DNA helicase activity TAS 9889278
GO:0004004 ATP-dependent RNA helicase activity TAS 9889278
genes like me logo Genes that share ontologies with G3BP1: view
genes like me logo Genes that share phenotypes with G3BP1: view

Animal Model Products

CRISPR Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for G3BP1 Gene

Localization for G3BP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for G3BP1 Gene

Cytoplasm. Cytoplasm, cytosol. Cytoplasmic granule. Cell membrane. Nucleus. Note=Cytoplasmic in proliferating cells, can be recruited to the plasma membrane in exponentially growing cells (By similarity). Cytosolic and partially nuclear in resting cells. Recruited to stress granules (SGs) upon either arsenite or high temperature treatment. Recruitment to SGs is influenced by HRAS. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for G3BP1 Gene COMPARTMENTS Subcellular localization image for G3BP1 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for G3BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with G3BP1: view

Pathways for G3BP1 Gene

SuperPathways for G3BP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for G3BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006810 transport IEA --
GO:0007265 Ras protein signal transduction TAS 8649363
GO:0008152 metabolic process TAS 9889278
GO:0032508 DNA duplex unwinding TAS 9889278
genes like me logo Genes that share ontologies with G3BP1: view

No data available for Pathways by source for G3BP1 Gene

Compounds for G3BP1 Gene

(2) HMDB Compounds for G3BP1 Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4
Phenylephrine
  • Adrianol
59-42-7

(2) Novoseek inferred chemical compound relationships for G3BP1 Gene

Compound -log(P) Hits PubMed IDs
serine 10.1 1
tyrosine 8.85 2
genes like me logo Genes that share compounds with G3BP1: view

Transcripts for G3BP1 Gene

Unigene Clusters for G3BP1 Gene

GTPase activating protein (SH3 domain) binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for G3BP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for G3BP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - - - - - - - - - - - -
SP5: - - -
SP6: - -
SP7: -
SP8: - -

Relevant External Links for G3BP1 Gene

GeneLoc Exon Structure for
G3BP1
ECgene alternative splicing isoforms for
G3BP1

Expression for G3BP1 Gene

mRNA expression in normal human tissues for G3BP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for G3BP1 Gene

SOURCE GeneReport for Unigene cluster for G3BP1 Gene Hs.587054

mRNA Expression by UniProt/SwissProt for G3BP1 Gene

Q13283-G3BP1_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with G3BP1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for G3BP1 Gene

Orthologs for G3BP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for G3BP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia G3BP1 35
  • 99.79 (n)
  • 99.79 (a)
G3BP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia G3BP 36
  • 97 (a)
OneToOne
G3BP1 35
  • 91.68 (n)
  • 96.77 (a)
dog
(Canis familiaris)
Mammalia G3BP1 35
  • 93.05 (n)
  • 98.06 (a)
G3BP1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia G3bp1 35
  • 86.49 (n)
  • 93.97 (a)
G3bp1 16
G3bp1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia G3BP1 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia G3bp1 35
  • 86.71 (n)
  • 93.97 (a)
chicken
(Gallus gallus)
Aves G3BP1 35
  • 80.53 (n)
  • 85.99 (a)
G3BP1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia G3BP1 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia g3bp-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia g3bp1 35
  • 72.4 (n)
  • 78.71 (a)
zebrafish
(Danio rerio)
Actinopterygii g3bp1 35
  • 64.43 (n)
  • 66.16 (a)
g3bp1 36
  • 67 (a)
OneToOne
wufj17h05 35
fruit fly
(Drosophila melanogaster)
Insecta rin 36
  • 23 (a)
OneToMany
Species with no ortholog for G3BP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for G3BP1 Gene

ENSEMBL:
Gene Tree for G3BP1 (if available)
TreeFam:
Gene Tree for G3BP1 (if available)

Paralogs for G3BP1 Gene

Paralogs for G3BP1 Gene

Pseudogenes.org Pseudogenes for G3BP1 Gene

genes like me logo Genes that share paralogs with G3BP1: view

Variants for G3BP1 Gene

Sequence variations from dbSNP and Humsavar for G3BP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs14509 -- 151,811,253(-) GGAGA(G/T)AGAAC utr-variant-3-prime
rs892005 -- 151,801,060(+) TGTTT(A/G)AGTAA intron-variant
rs892006 -- 151,801,329(+) ACCTA(A/C)TTGGA intron-variant
rs973529 -- 151,808,597(+) ATTCC(C/T)TTAAT utr-variant-3-prime
rs1042877 -- 151,810,543(+) TTCTC(A/G)TAGTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for G3BP1 Gene

Variant ID Type Subtype PubMed ID
nsv5070 CNV Insertion 18451855
esv272455 CNV Insertion 20981092

Relevant External Links for G3BP1 Gene

HapMap Linkage Disequilibrium report
G3BP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for G3BP1 Gene

Disorders for G3BP1 Gene

(5) Novoseek inferred disease relationships for G3BP1 Gene

Disease -log(P) Hits PubMed IDs
carcinoma squamous cell 11.4 2
metastasis 7.58 6
tumors 5.5 12
cancer 5.49 3
breast cancer 0 8
genes like me logo Genes that share disorders with G3BP1: view

No data available for UniProtKB/Swiss-Prot for G3BP1 Gene

Publications for G3BP1 Gene

  1. A Ras-GTPase-activating protein SH3-domain-binding protein. (PMID: 8649363) Parker F. … Tocque B. (Mol. Cell. Biol. 1996) 2 3 4 23
  2. Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway. (PMID: 9889278) Costa M. … Falaschi A. (Nucleic Acids Res. 1999) 2 3 4 23
  3. Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease. (PMID: 11439350) Soncini C. … Draetta G. (Oncogene 2001) 3 4 23
  4. The RasGAP-associated endoribonuclease G3BP assembles stress granules. (PMID: 12642610) Tourriere H. … Tazi J. (J. Cell Biol. 2003) 3 4 23
  5. A novel phosphorylation-dependent RNase activity of GAP-SH3 binding protein: a potential link between signal transduction and RNA stability. (PMID: 9632780) Gallouzi I.E. … Tazi J. (Mol. Cell. Biol. 1998) 3 23

Products for G3BP1 Gene

Sources for G3BP1 Gene

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