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G3BP1 Gene

protein-coding GIFtS: 54

GC05P151132

GTPase activating protein (SH3 domain) binding protein 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.6.1.- ^³
G3BP ^¹, ², ³
G3BP-1 ^³
HDH-VIII ^¹, ², ³
MGC111040 ^²
OTTHUMP00000160618 ^²

Descriptions
ATP-dependent DNA helicase VIII ^³
GAP SH3 domain-binding protein 1 ^³
GAP binding protein ^²
GTPase activating protein (SH3 domain) binding protein 1 ^²
Ras-GTPase-activating protein SH3-domain-binding protein ^²
RasGAP-associated endoribonuclease G3BP ^²

External Ids
HGNC: 30292¹
Entrez Gene: 10146²
UniProtKB: Q13283³
Ensembl: ENSG00000145907⁷

Search outside databases for aliases for G3BP1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for G3BP1:

This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed

substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion.

This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element

of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein

by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene

have been described, but the full-length nature of some of these variants has not been determined.

[provided by RefSeq]

UniProtKB/Swiss-Prot: G3BP1_HUMAN, Q13283

Function: May be a regulated effector of stress granule assembly. Phosphorylation-dependent

sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and

cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds

preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging

3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates

with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the

bound single-stranded DNA

Gene Wiki entry for G3BP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.1 Ensembl cytogenetic band: 5q33.1 HGNC cytogenetic band: 5q33.1

G3BP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P151132: (about GC identifiers)

Start:	151,131,664 bp from pter
End:	151,172,539 bp from pter
Size:	40,876 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000005.8 NT_029289.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: G3BP1_HUMAN, Q13283 (See protein sequence)

Recommended Name: Ras GTPase-activating protein-binding protein 1

Size: 466 amino acids; 52164 Da

Cofactor: Magnesium. Required for helicase activity

Subunit: Binds to the SH3 domain of Ras GTPase-activating protein (RASA1) in proliferating cells.

No interaction in quiescent cells Component of a TAU mRNP complex, at least composed of IGF2BP1,

ELAVL4 and G3BP (By similarity). Interacts with USP10, and may regulate it. Forms homodimers and

oligomers

Subcellular location: Cytoplasm. Cytoplasm, cytosol. Cell membrane. Nucleus. Note=Cytoplasmic in

proliferating cells, can be recruited to the plasma membrane in exponentially growing cells (By

similarity). Cytosolic and partially nuclear in resting cells. Recruited to stress granules (SGs)

upon either arsenite or high temperature treatment. Recruitment to SGs is influenced by HRAS

Post-translational modifications:

Phosphorylated exclusively on serine residues. Hyperphosphorylated in quiescent fibroblasts.

Hypophosphorylation leads to a decrease in endoribonuclease activity (By similarity).

RASA1-dependent phosphorylation of Ser-149 induces a conformational change that prevents

self-association. Dephosphorylation after HRAS activation is required for stress granule assembly.

Ser-149 phosphorylation induces partial nuclear localization¹

Arg-435 is dimethylated, probably to asymmetric dimethylarginine¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_005745.1 NP_938405.1

ENSEMBL proteins:

ENSP00000274596 ENSP00000377681 ENSP00000348578

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (G3BP)
	Human Recombinant Proteins from Abnova (G3BP1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	TAS	9889278
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	IEA	--

About this table

Antibodies for G3BP1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for G3BP1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (G3BP), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (G3BP1)
	Novus Biologicals Antibody for G3BP

Assays for G3BP1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q13283

ProtoNet protein and cluster: Q13283

2 Blocks protein families:

IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

IPB002075 Nuclear transport factor 2 (NTF2)

UniProtKB/Swiss-Prot: G3BP1_HUMAN, Q13283

Domain: The NTF2 domain mediates multimerization

Similarity: Contains 1 NTF2 domain

Similarity: Contains 1 RRM (RNA recognition motif) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (G3BP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (G3BP1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005754

Applied Biosystems Silencer® siRNAs for G3BP1

Sigma-Aldrich siRNA for G3BP1

Sigma-Aldrich shRNA Panels and shRNA for G3BP1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for G3BP1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005754
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005754
untagged cDNA clones in CMV expression vector (see all 3): NM_005754

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_198395

UniProtKB/Swiss-Prot: G3BP1_HUMAN, Q13283

Function: May be a regulated effector of stress granule assembly. Phosphorylation-dependent

sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and

cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds

preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging

3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates

with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the

bound single-stranded DNA

Enzyme Number (IUBMB): EC 3.6.1.-

10 MGI mutant phenotypes (inferred from 1 allele) (MGI details for G3bp1):

	cellular	craniofacial	embryogenesis	growth/size
lethality-prenatal/perinatal	limbs/digits/tail	nervous system	other	respiratory system

5/10 Gene Ontology (GO) molecular function terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003677	DNA binding	IEA	--
GO:0003723	RNA binding	IEA	--
GO:0004003	ATP-dependent DNA helicase activity	TAS	9889278
GO:0004004	ATP-dependent RNA helicase activity	TAS	9889278

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for G3BP1

5/20 Interacting proteins for G3BP1 (Q13283^{1, 2} ENSP00000348578³) via UniProtKB, MINT, and/or STRING (see all 20 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CSK	P41240², ENSP00000220003³	MINT-61272 MINT-61275 MINT-61273 STRING (score=.74)
LCK	P06239², ENSP00000328213³	MINT-61274 MINT-61276 STRING (score=.713)
FYN	P06241², ENSP00000357656³	MINT-61277 STRING (score=.72)
JAK2	O60674², ENSP00000371067³	MINT-61281 STRING (score=.706)
PUF60	Q9UHX1¹	EBI-1047359, EBI-1053259

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	IEA	--
GO:0007265	Ras protein signal transduction	TAS	8649363

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for G3BP1
1 Novoseek chemical compound relationship for G3BP1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	0.78	2	15743820 (1), 9575347 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (G3BP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (G3BP1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005754

Sigma-Aldrich siRNA for G3BP1

Sigma-Aldrich shRNA Panels and shRNA for G3BP1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005754 NM_198395

REFSEQ mRNAs for G3BP1 gene (2 alternative transcripts):

NM_005754.2 NM_198395.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005754 NM_198395

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005754
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005754
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_005754

Additional cDNA sequence:

AK130003.1 AK222606.1 AK300098.1 AK303580.1 AK309172.1 AK311635.1 AK312572.1 BC006997.1

BC108278.1 BT019384.1 BX647869.1 BX648012.1 CR536535.1 CR601908.1 CR614415.1 CR625819.1

U32519.1

24/29 DOTS entries (see all 29 ):

DT.417505 DT.215685 DT.92410058 DT.92452506 DT.97860154 DT.99927264 DT.100037754 DT.100645520

DT.100706249 DT.215684 DT.120868951 DT.120868984 DT.120869069 DT.92452517 DT.95230237 DT.100059279

DT.100653969 DT.120869009 DT.120869041 DT.120869070 DT.40113075 DT.75186461 DT.92452516 DT.95230232

24/462 AceView cDNA sequences (see all 462 ):

BM997120 NM_198395 BU192715 AW675016 AI805614 BE301413 BQ215164 AA425230

BF196887 BM797359 BE326309 AI679147 AW516391 AU103593 AU103595 BU620479

BX405314 AA136500 Z39647 CA944886 AI358600 CB143400 Z42330 AA345946

highest scoring ESTs for G3BP1:

AI394318 U32519 AA129537 AA136500 AA256363 AA357385 AA360761 AA360892 AA425151 AA425230

Unigene Cluster for G3BP1:

GTPase activating protein (SH3 domain) binding protein 1

Hs.587054 [show with all ESTs]

Unigene Representative Sequence: NM_005754

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for G3BP1 (see all 8 )

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9a	·	9b	·	9c	^	10	^	11a	·	11b	^	12	^	13	^	14a	·	14b
SP1:							-								-										-
SP2:							-		-						-										-
SP3:							-						-		-		-								-
SP4:							-		-						-								-		-		-		-		-		-		-		-		-		-		-		-		-
SP5:																																											-		-		-

About this scheme

ECgene alternative splicing isoforms for G3BP1

3 Ensembl transcripts including schematic representations:

ENST00000274596 ENST00000394123 ENST00000356245

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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G3BP1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for G3BP1

¹ / ² / ³

17 probe-sets matching G3BP1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
42924_at²^{, 3}	U95-B	1	1.00	1.00	0.74	0.56	AA593671	0.40	1.00	0.76	1
41133_at²^{, 3}	U95-A	1	1.00	1.00	0.79	1.02	U32519	1.00	1.00	1.00	1
65859_at²	U95-C	1	1.00	1.00	0.43	1.48	--	--	--	--	--
63830_at²^{, 3}	U95-C	1	1.00	1.00	0.76	1.38	AI394318	1.00	1.00	1.00	1
61187_at²	U95-C	1	1.00	1.00	0.53	0.67	--	--	--	--	--
70536_at²^{, 3}	U95-E	1	0.50	1.00	0.22	0.91	AA026297	0.40	1.00	0.76	1
242422_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
201503_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BG500067	0.80	1.00	0.91	1
244396_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BE673925	0.40	1.00	0.76	1
225007_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
201514_s_at²^{, 3}	U133-A	2	1.00	0.86	--	--	NM_005754	0.60	1.00	0.82	1
222187_x_at²	U133-A	14	1.00	0.78	--	--	--	--	--	--	--
201503_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
225007_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201514_s_at²	U133Plus2	2	1.00	0.86	--	--	--	--	--	--	--
222187_x_at²	U133Plus2	14	1.00	0.78	--	--	--	--	--	--	--
1557350_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--

GeneDecks G3BP1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.587054
UniProtKB/Swiss-Prot: G3BP1_HUMAN, Q13283
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for G3BP1 gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	G3BP1¹	--	GTPase activating protein (SH3 domain) binding protein more	93.05(n) 98.06(a)	479322 XM_536460.2 XP_536460.1
chimpanzee (Pan troglodytes)	G3BP1¹	--	GTPase activating protein (SH3 domain) binding protein more	99.79(n) 99.79(a)	471711 XM_001169113.1 XP_001169113.1
cow (Bos taurus)	G3BP1¹	--	GTPase activating protein (SH3 domain) binding protein more	91.68(n) 96.77(a)	534214 NM_001037611.1 NP_001032700.1
rat (Rattus norvegicus)	G3bp1¹	--	GTPase activating protein (SH3 domain) binding protein more	86.71(n) 93.97(a)	171092 XM_340802.3 XP_340803.2
mouse (Mus musculus)	G3bp1^{1, 5}	11⁵	Ras-GTPase-activating protein SH3-domain binding protein more^{1, 5}	86.49(n)¹ 93.97(a)¹	27041¹ NM_013716.2¹ NP_038744.1¹ AB001927⁵ AF143947⁵ (see all 23)

About this table Species with no ortholog for G3BP1

ENSEMBL Gene Tree for G3BP1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for G3BP1 gene

G3BP2²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/139 NCBI SNPs in G3BP1 are shown (see all 139 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 62)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs1062177^1,2	A,C,F,H,O	151164894(+)	`GGTATC/TTAATC`	2	--	ut3¹		6	MN EU WA NA	560
	rs2915868^1,2	A,C,F,H,O	151153214(-)	`CTAAGC/TATGTA`	2	--	int¹		11	EU EA WA NA	910
	rs892006^1,2	A,C,F,H,O	151161083(+)	`ACCTAC/ATTGGA`	2	--	int¹		14	EA NA EU WA	1040
	rs6881068^1,2	A,C,F,H	151139056(+)	`tacacT/Cgaatc`	2	--	int¹		4	EU EA WA	418
	rs2964574^1,2	A,C,F,H	151135904(-)	`AGTGTC/TATGGT`	2	--	int¹		3	EA WA	258
	rs7734314^1,2	A,C,F,H	151162829(+)	`AGCCCC/GTTAAC`	2	--	int¹		15	EU EA WA NA	1396
	rs7719617^1,2	A,C,F,H	151147573(+)	`aatgtA/Tttcaa`	2	--	int¹		4	EU EA WA	394
	rs10477000^1,2	A,C,F,H	151155941(+)	`ttgggT/Ctgctg`	2	--	int¹		7	EU EA WA NA	540
	rs6898736^1,2	A,C,F,H	151145641(+)	`TTTGTC/TCCCGG`	2	--	int¹		4	EU EA WA	414
	rs10074385^1,2	A,C,F,H	151155530(+)	`AGGCAA/GTCTAC`	2	--	int¹		4	EU EA WA	388

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HapMap Linkage Disequilibrium images for G3BP1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 608431

5 Novoseek disease relationships for G3BP1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	9.79	8	17696235 (2), 11779432 (2), 17253181 (1), 16091175 (1)
tumors	3.71	13	11146228 (4), 16091175 (3), 11888885 (2), 17253181 (1) (see all 5)
cancer	3.17	4	11779432 (2), 11888885 (1)
breast cancer	0.00	11	11888885 (4), 16091175 (3), 12587999 (1)
carcinoma squamous cell	0.00	2	17696235 (2)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/65 PubMed articles for G3BP1 gene (see all 65 ):

A Ras-GTPase-activating protein SH3-domain-binding protein. (PubMed id 8649363)^{1, 2, 3, 4} Parker F.... Tocque B. (1996)
Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway. (PubMed id 9889278)^{1, 2, 3, 4} Costa M....Falaschi A. (1999)
The RasGAP-associated endoribonuclease G3BP assembles stress granules. (PubMed id 12642610)^{1, 3, 4} Tourriere H.... Tazi J. (2003)
Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease. (PubMed id 11439350)^{1, 3, 4} Soncini C.... Draetta G. (2001)
Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)^{3, 4} Nousiainen M.... Koerner R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PubMed id 16094384)^{3, 4} Tao W.A.... Aebersold R. (2005)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. (PubMed id 15782174)^{3, 4} Ong S.E.... Mann M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 10146	HGNC: 30292	AceView: G3BP	Ensembl:ENSG00000145907	euGenes: HUgn10146
ECgene: G3BP1	H-InvDB: G3BP1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for G3BP1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for G3BP1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for G3BP1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for G3BP1		Antibodies for G3BP1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for G3BP1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (G3BP1)
	Antibodies (G3BP1)
	Chimera RNAi (G3BP1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (G3BP)
	Antibodies (G3BP)

Search OriGene for G3BP1

Search Tocris compounds for G3BP1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for G3BP

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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G3BP1 Gene at Home site.
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G3BP1 Gene

protein-coding GIFtS: 54

Aliases &
Descriptions
for G3BP1

Summaries
for G3BP1

Genomic Location
for G3BP1

Proteins
for G3BP1

Protein Domains/
Families
for G3BP1

Gene Function
for G3BP1

Pathways & Interactions
for G3BP1

Drugs & Compounds
for G3BP1

Transcripts
for G3BP1

Expression
for G3BP1

Orthologs
for G3BP1

Paralogs
for G3BP1

SNPs/Variants
for G3BP1

Disorders & Mutations
for G3BP1

Medical News
for G3BP1

Publications
for G3BP1

Search for G3BP1

Genome Databases showing G3BP1

Other Databases showing G3BP1

Specialized Databases showing G3BP1

Licensable Technologies
for G3BP1

Services
for G3BP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

G3BP1 Gene

protein-coding GIFtS: 54

Aliases & Descriptionsfor G3BP1

Summariesfor G3BP1

Genomic Locationfor G3BP1

Proteinsfor G3BP1

Protein Domains/Familiesfor G3BP1

Gene Functionfor G3BP1

Pathways & Interactionsfor G3BP1

Drugs & Compoundsfor G3BP1

Transcriptsfor G3BP1

Expression for G3BP1

Orthologsfor G3BP1

Paralogsfor G3BP1

SNPs/Variantsfor G3BP1

Disorders & Mutationsfor G3BP1

Medical Newsfor G3BP1

Publicationsfor G3BP1

Search for G3BP1

Genome Databases showing G3BP1

Other Databases showing G3BP1

Specialized Databases showing G3BP1

Licensable Technologiesfor G3BP1

Servicesfor G3BP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for G3BP1

Summaries
for G3BP1

Genomic Location
for G3BP1

Proteins
for G3BP1

Protein Domains/
Families
for G3BP1

Gene Function
for G3BP1

Pathways & Interactions
for G3BP1

Drugs & Compounds
for G3BP1

Transcripts
for G3BP1

Expression
for G3BP1

Orthologs
for G3BP1

Paralogs
for G3BP1

SNPs/Variants
for G3BP1

Disorders & Mutations
for G3BP1

Medical News
for G3BP1

Publications
for G3BP1

Licensable Technologies
for G3BP1

Services
for G3BP1