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Aliases for G2E3 Gene

Aliases for G2E3 Gene

  • G2/M-Phase Specific E3 Ubiquitin Protein Ligase 2 3 5
  • KIAA1333 2 3 4
  • PHD Finger Protein 7B 2 3
  • G2/M-Phase Specific E3 Ubiquitin Ligase 3
  • EC 6.3.2.- 4
  • EC 6.3.2 63
  • PHF7B 3

External Ids for G2E3 Gene

Previous HGNC Symbols for G2E3 Gene

  • KIAA1333

Previous GeneCards Identifiers for G2E3 Gene

  • GC14P030099
  • GC14P031028
  • GC14P011145

Summaries for G2E3 Gene

GeneCards Summary for G2E3 Gene

G2E3 (G2/M-Phase Specific E3 Ubiquitin Protein Ligase) is a Protein Coding gene. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is PHF7.

UniProtKB/Swiss-Prot for G2E3 Gene

  • E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.

Gene Wiki entry for G2E3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for G2E3 Gene

Genomics for G2E3 Gene

Regulatory Elements for G2E3 Gene

Promoters for G2E3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around G2E3 on UCSC Golden Path with GeneCards custom track

Genomic Location for G2E3 Gene

Chromosome:
14
Start:
30,559,123 bp from pter
End:
30,620,063 bp from pter
Size:
60,941 bases
Orientation:
Plus strand

Genomic View for G2E3 Gene

Genes around G2E3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
G2E3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for G2E3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for G2E3 Gene

Proteins for G2E3 Gene

  • Protein details for G2E3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L622-G2E3_HUMAN
    Recommended name:
    G2/M phase-specific E3 ubiquitin-protein ligase
    Protein Accession:
    Q7L622
    Secondary Accessions:
    • Q9BVR2
    • Q9H9E9
    • Q9NXC0
    • Q9P2L3

    Protein attributes for G2E3 Gene

    Size:
    706 amino acids
    Molecular mass:
    80504 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92571.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14280.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for G2E3 Gene

Proteomics data for G2E3 Gene at MOPED

Selected DME Specific Peptides for G2E3 Gene

Post-translational modifications for G2E3 Gene

  • Ubiquitination at Lys 322, Lys 333, and Lys 442
  • Modification sites at PhosphoSitePlus

Domains & Families for G2E3 Gene

Gene Families for G2E3 Gene

Suggested Antigen Peptide Sequences for G2E3 Gene

Graphical View of Domain Structure for InterPro Entry

Q7L622

UniProtKB/Swiss-Prot:

G2E3_HUMAN :
  • Ubiquitin ligase activity is mediated by two distinct domains, PHD-type zinc fingers 2 and 3. The use of these distinct domains may allow ubiquitination of different targets by each domain. The HECT domain is catalytically inactive and does not contribute to this activity.
  • Contains 3 PHD-type zinc fingers.
Domain:
  • Ubiquitin ligase activity is mediated by two distinct domains, PHD-type zinc fingers 2 and 3. The use of these distinct domains may allow ubiquitination of different targets by each domain. The HECT domain is catalytically inactive and does not contribute to this activity.
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
Similarity:
  • Contains 3 PHD-type zinc fingers.
genes like me logo Genes that share domains with G2E3: view

Function for G2E3 Gene

Molecular function for G2E3 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.
UniProtKB/Swiss-Prot Induction:
Up-regulated approximately 4-fold in G2 when compared to S phase. Down-regulated approximately 3-fold by gamma-irradiation.

Enzyme Numbers (IUBMB) for G2E3 Gene

Gene Ontology (GO) - Molecular Function for G2E3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding IEA,IPI 25416956
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with G2E3: view
genes like me logo Genes that share phenotypes with G2E3: view

Animal Model Products

CRISPR Products

miRNA for G2E3 Gene

miRTarBase miRNAs that target G2E3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for G2E3 Gene

Localization for G2E3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for G2E3 Gene

Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In the nucleus, delocalizes from the nucleolus to the nucleoplasm in response to DNA damage.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for G2E3 Gene COMPARTMENTS Subcellular localization image for G2E3 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for G2E3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with G2E3: view

Pathways & Interactions for G2E3 Gene

SuperPathways for G2E3 Gene

No Data Available

UniProtKB/Swiss-Prot Q7L622-G2E3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for G2E3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with G2E3: view

No data available for Pathways by source and SIGNOR curated interactions for G2E3 Gene

Drugs & Compounds for G2E3 Gene

No Compound Related Data Available

Transcripts for G2E3 Gene

Unigene Clusters for G2E3 Gene

G2/M-phase specific E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for G2E3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b
SP1: - - - - - -
SP2: - - - -
SP3: - - - -
SP4:
SP5:
SP6:

Relevant External Links for G2E3 Gene

GeneLoc Exon Structure for
G2E3
ECgene alternative splicing isoforms for
G2E3

Expression for G2E3 Gene

mRNA expression in normal human tissues for G2E3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for G2E3 Gene



SOURCE GeneReport for Unigene cluster for G2E3 Gene Hs.509008

mRNA Expression by UniProt/SwissProt for G2E3 Gene

Q7L622-G2E3_HUMAN
Tissue specificity: Predominantly expressed in brain, liver, kidney, testes and ovary.
genes like me logo Genes that share expression patterns with G2E3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for G2E3 Gene

Orthologs for G2E3 Gene

This gene was present in the common ancestor of animals.

Orthologs for G2E3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia G2E3 35
  • 90.47 (n)
  • 86.77 (a)
G2E3 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia G2E3 35
  • 91.93 (n)
  • 89.38 (a)
G2E3 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia G2e3 35
  • 84.33 (n)
  • 79.91 (a)
G2e3 16
G2e3 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia G2E3 35
  • 99.67 (n)
  • 99.58 (a)
G2E3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia G2e3 35
  • 85.21 (n)
  • 82.36 (a)
oppossum
(Monodelphis domestica)
Mammalia G2E3 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia G2E3 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves G2E3 35
  • 68.52 (n)
  • 63.94 (a)
G2E3 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia G2E3 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia g2e3 35
  • 57.3 (n)
  • 54.03 (a)
zebrafish
(Danio rerio)
Actinopterygii g2e3 35
  • 52.48 (n)
  • 43.95 (a)
g2e3 36
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9576 36
  • 22 (a)
ManyToMany
pie 36
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8734 36
  • 32 (a)
OneToOne
Species with no ortholog for G2E3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for G2E3 Gene

ENSEMBL:
Gene Tree for G2E3 (if available)
TreeFam:
Gene Tree for G2E3 (if available)

Paralogs for G2E3 Gene

Paralogs for G2E3 Gene

Pseudogenes.org Pseudogenes for G2E3 Gene

genes like me logo Genes that share paralogs with G2E3: view

Variants for G2E3 Gene

Sequence variations from dbSNP and Humsavar for G2E3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs17096934 - 30,598,542(+) TGAGC(A/G)TTGTG intron-variant, reference, missense
rs170663 -- 30,580,203(-) aaaaa(A/C)caaaa intron-variant
rs170665 -- 30,599,139(-) aggac(A/G)tagac intron-variant
rs172947 -- 30,591,755(-) aatta(A/G)gttaa intron-variant
rs764811 -- 30,606,202(-) TTACA(A/T)GTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for G2E3 Gene

Variant ID Type Subtype PubMed ID
nsv526536 CNV Gain 19592680
esv33189 CNV Loss 17666407
nsv901581 CNV Gain 21882294
esv2125800 CNV Deletion 18987734

Variation tolerance for G2E3 Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.35; 53.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for G2E3 Gene

HapMap Linkage Disequilibrium report
G2E3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for G2E3 Gene

Disorders for G2E3 Gene

Relevant External Links for G2E3

Genetic Association Database (GAD)
G2E3
Human Genome Epidemiology (HuGE) Navigator
G2E3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
G2E3

No disorders were found for G2E3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for G2E3 Gene

Publications for G2E3 Gene

  1. G2E3 is a dual function ubiquitin ligase required for early embryonic development. (PMID: 18511420) Brooks W.S. … Crawford D.F. (J. Biol. Chem. 2008) 2 3 4 67
  2. G2E3 is a nucleo-cytoplasmic shuttling protein with DNA damage responsive localization. (PMID: 17239372) Brooks W.S. … Crawford D.F. (Exp. Cell Res. 2007) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for G2E3 Gene

Sources for G2E3 Gene

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