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Aliases for G2E3 Gene

Aliases for G2E3 Gene

  • G2/M-Phase Specific E3 Ubiquitin Protein Ligase 2 3 5
  • KIAA1333 2 3 4
  • G2/M Phase-Specific HECT-Type E3 Ubiquitin Transferase 3 4
  • PHD Finger Protein 7B 2 3
  • G2/M Phase-Specific E3 Ubiquitin-Protein Ligase 3
  • G2/M-Phase Specific E3 Ubiquitin Ligase 3
  • EC 2.3.2.26 4
  • EC 6.3.2 61
  • PHF7B 3

External Ids for G2E3 Gene

Previous HGNC Symbols for G2E3 Gene

  • KIAA1333

Previous GeneCards Identifiers for G2E3 Gene

  • GC14P030099
  • GC14P031028
  • GC14P011145

Summaries for G2E3 Gene

GeneCards Summary for G2E3 Gene

G2E3 (G2/M-Phase Specific E3 Ubiquitin Protein Ligase) is a Protein Coding gene. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is PHF7.

UniProtKB/Swiss-Prot for G2E3 Gene

  • E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.

Gene Wiki entry for G2E3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for G2E3 Gene

Genomics for G2E3 Gene

Regulatory Elements for G2E3 Gene

Enhancers for G2E3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G031164 1.1 Ensembl ENCODE 5.2 +606.6 606569 2.6 FOXA2 RARA FOS MIXL1 CEBPB PPARG MIER3 CEBPA RCOR2 NBN RNU6-541P HECTD1 G2E3
GH14G031199 1.1 Ensembl ENCODE 4.9 +641.0 641005 0.7 HDAC1 PKNOX1 ARNT TCF12 GATA2 ZNF366 FOS ETV6 NCOA1 ZEB2 G2E3 HECTD1 RNU6-541P
GH14G031194 1 Ensembl ENCODE 5.2 +636.7 636744 3.7 FOXA2 ZNF384 TCF12 GTF3C2 POLR2A EGR1 FOS NR2F6 THAP11 GATAD2A RPL21P5 RNU6-541P G2E3 HECTD1
GH14G030586 0.4 FANTOM5 12.4 +27.1 27087 0.1 IKZF1 ZNF592 G2E3 SCFD1
GH14G030558 1.1 ENCODE 0.7 +0.4 416 2.7 HNRNPUL1 FOXA2 MLX AGO1 ZFP64 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 SCFD1 G2E3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around G2E3 on UCSC Golden Path with GeneCards custom track

Promoters for G2E3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000067148 477 2401 HNRNPUL1 FOXA2 MLX AGO1 ZFP64 WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for G2E3 Gene

Chromosome:
14
Start:
30,559,123 bp from pter
End:
30,620,063 bp from pter
Size:
60,941 bases
Orientation:
Plus strand

Genomic View for G2E3 Gene

Genes around G2E3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
G2E3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for G2E3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for G2E3 Gene

Proteins for G2E3 Gene

  • Protein details for G2E3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L622-G2E3_HUMAN
    Recommended name:
    G2/M phase-specific E3 ubiquitin-protein ligase
    Protein Accession:
    Q7L622
    Secondary Accessions:
    • Q9BVR2
    • Q9H9E9
    • Q9NXC0
    • Q9P2L3

    Protein attributes for G2E3 Gene

    Size:
    706 amino acids
    Molecular mass:
    80504 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92571.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14280.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for G2E3 Gene

Selected DME Specific Peptides for G2E3 Gene

Q7L622:
  • YCLLMSSGIWQRG
  • FQKEMLRMGIHIPEKDASWELE

Post-translational modifications for G2E3 Gene

  • Ubiquitination at isoforms=322, Lys333, and Lys442
  • Modification sites at PhosphoSitePlus

Domains & Families for G2E3 Gene

Gene Families for G2E3 Gene

Suggested Antigen Peptide Sequences for G2E3 Gene

Graphical View of Domain Structure for InterPro Entry

Q7L622

UniProtKB/Swiss-Prot:

G2E3_HUMAN :
  • Ubiquitin ligase activity is mediated by two distinct domains, PHD-type zinc fingers 2 and 3. The use of these distinct domains may allow ubiquitination of different targets by each domain. The HECT domain is catalytically inactive and does not contribute to this activity.
Domain:
  • Ubiquitin ligase activity is mediated by two distinct domains, PHD-type zinc fingers 2 and 3. The use of these distinct domains may allow ubiquitination of different targets by each domain. The HECT domain is catalytically inactive and does not contribute to this activity.
genes like me logo Genes that share domains with G2E3: view

Function for G2E3 Gene

Molecular function for G2E3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.
UniProtKB/Swiss-Prot Induction:
Up-regulated approximately 4-fold in G2 when compared to S phase. Down-regulated approximately 3-fold by gamma-irradiation.

Enzyme Numbers (IUBMB) for G2E3 Gene

Gene Ontology (GO) - Molecular Function for G2E3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with G2E3: view
genes like me logo Genes that share phenotypes with G2E3: view

Animal Model Products

CRISPR Products

miRNA for G2E3 Gene

miRTarBase miRNAs that target G2E3

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for G2E3 Gene

Localization for G2E3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for G2E3 Gene

Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In the nucleus, delocalizes from the nucleolus to the nucleoplasm in response to DNA damage. {ECO:0000269 PubMed:17239372}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for G2E3 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for G2E3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with G2E3: view

Pathways & Interactions for G2E3 Gene

No Data Available

UniProtKB/Swiss-Prot Q7L622-G2E3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for G2E3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007275 multicellular organism development IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with G2E3: view

No data available for Pathways by source and SIGNOR curated interactions for G2E3 Gene

Drugs & Compounds for G2E3 Gene

No Compound Related Data Available

Transcripts for G2E3 Gene

Unigene Clusters for G2E3 Gene

G2/M-phase specific E3 ubiquitin protein ligase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for G2E3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b
SP1: - - - - - -
SP2: - - - -
SP3: - - - -
SP4:
SP5:
SP6:

Relevant External Links for G2E3 Gene

GeneLoc Exon Structure for
G2E3
ECgene alternative splicing isoforms for
G2E3

Expression for G2E3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for G2E3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for G2E3 Gene



NURSA nuclear receptor signaling pathways regulating expression of G2E3 Gene:

G2E3

SOURCE GeneReport for Unigene cluster for G2E3 Gene:

Hs.509008

mRNA Expression by UniProt/SwissProt for G2E3 Gene:

Q7L622-G2E3_HUMAN
Tissue specificity: Predominantly expressed in brain, liver, kidney, testes and ovary.

Evidence on tissue expression from TISSUES for G2E3 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with G2E3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for G2E3 Gene

Orthologs for G2E3 Gene

This gene was present in the common ancestor of animals.

Orthologs for G2E3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia G2E3 34 35
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia G2E3 34 35
  • 91.93 (n)
cow
(Bos Taurus)
Mammalia G2E3 34 35
  • 90.47 (n)
rat
(Rattus norvegicus)
Mammalia G2e3 34
  • 85.21 (n)
mouse
(Mus musculus)
Mammalia G2e3 34 16 35
  • 84.33 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia G2E3 35
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia G2E3 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves G2E3 34 35
  • 68.52 (n)
lizard
(Anolis carolinensis)
Reptilia G2E3 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia g2e3 34
  • 57.3 (n)
zebrafish
(Danio rerio)
Actinopterygii g2e3 35 34
  • 52.48 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9576 35
  • 22 (a)
ManyToMany
pie 35
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8734 35
  • 32 (a)
OneToOne
Species where no ortholog for G2E3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for G2E3 Gene

ENSEMBL:
Gene Tree for G2E3 (if available)
TreeFam:
Gene Tree for G2E3 (if available)

Paralogs for G2E3 Gene

Paralogs for G2E3 Gene

Pseudogenes.org Pseudogenes for G2E3 Gene

genes like me logo Genes that share paralogs with G2E3: view

Variants for G2E3 Gene

Sequence variations from dbSNP and Humsavar for G2E3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000051154 -- 30,591,166(+) CTCAA(A/G)CTAGA intron-variant
rs1000097462 -- 30,613,613(+) AGTTT(C/T)GGTGG intron-variant
rs1000111851 -- 30,571,259(+) TTGTG(-/T)TTTTT intron-variant
rs1000157074 -- 30,583,519(+) GTTGG(A/G)AGGAT intron-variant
rs1000168284 -- 30,615,217(+) TGTGG(A/G)GGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for G2E3 Gene

Variant ID Type Subtype PubMed ID
esv2125800 CNV deletion 18987734
esv33189 CNV loss 17666407
nsv476835 CNV novel sequence insertion 20440878
nsv526536 CNV gain 19592680
nsv564169 CNV gain 21841781
nsv564171 CNV loss 21841781

Variation tolerance for G2E3 Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.35; 53.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for G2E3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
G2E3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for G2E3 Gene

Disorders for G2E3 Gene

Relevant External Links for G2E3

Genetic Association Database (GAD)
G2E3
Human Genome Epidemiology (HuGE) Navigator
G2E3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
G2E3

No disorders were found for G2E3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for G2E3 Gene

Publications for G2E3 Gene

  1. G2E3 is a dual function ubiquitin ligase required for early embryonic development. (PMID: 18511420) Brooks W.S. … Crawford D.F. (J. Biol. Chem. 2008) 2 3 4 64
  2. G2E3 is a nucleo-cytoplasmic shuttling protein with DNA damage responsive localization. (PMID: 17239372) Brooks W.S. … Crawford D.F. (Exp. Cell Res. 2007) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The G(2) DNA damage checkpoint delays expression of genes encoding mitotic regulators. (PMID: 11483598) Crawford D.F. … Piwnica-Worms H. (J. Biol. Chem. 2001) 3 4 64

Products for G2E3 Gene

Sources for G2E3 Gene

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