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Aliases for G0S2 Gene

Aliases for G0S2 Gene

  • G0/G1 Switch 2 2 3 5
  • Putative Lymphocyte G0/G1 Switch Gene 2 4
  • G0/G1 Switch Regulatory Protein 2 4
  • G0/G1switch 2 2

External Ids for G0S2 Gene

Previous GeneCards Identifiers for G0S2 Gene

  • GC01P208488
  • GC01P205554
  • GC01P206487
  • GC01P206928
  • GC01P206237
  • GC01P207915
  • GC01P209848
  • GC01P180523

Summaries for G0S2 Gene

GeneCards Summary for G0S2 Gene

G0S2 (G0/G1 Switch 2) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism.

UniProtKB/Swiss-Prot for G0S2 Gene

  • Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for G0S2 Gene

Genomics for G0S2 Gene

Regulatory Elements for G0S2 Gene

Enhancers for G0S2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G209644 2.1 FANTOM5 Ensembl ENCODE dbSUPER 52 -22.3 -22331 16.6 CREB3L1 MLX DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC G0S2 LAMB3 HSD11B1 LOC101930114 CAMK1G ENSG00000224260 MIR205HG MIR205 IRF6 TRAF3IP3
GH01G209765 1.9 FANTOM5 Ensembl ENCODE dbSUPER 30.7 +93.2 93247 6.9 HDGF PKNOX1 YBX1 ZNF766 ELK1 GATA2 FOS YY2 JUNB TBX21 G0S2 TRAF3IP3 DIEXF ENSG00000224260 LAMB3 IRF6 C1orf74 LOC101930114
GH01G209667 1.1 FANTOM5 dbSUPER 39.2 -7.3 -7285 0.4 CTCF PKNOX1 ESRRA ATF1 CEBPG FOSL1 NR2F6 RELB FOS IKZF2 G0S2 CAMK1G ENSG00000224260 LAMB3 TRAF3IP3 C1orf74
GH01G209746 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17.7 +72.1 72127 2.3 HDGF CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 G0S2 TRAF3IP3 LAMB3 GC01P209745
GH01G209754 1.5 FANTOM5 ENCODE dbSUPER 14.9 +81.8 81752 5.1 TBP PKNOX1 YBX1 TCF12 SCRT2 ETV6 IKZF2 CREM CBFB SP1 TRAF3IP3 G0S2 IRF6 C1orf74 LOC101930114
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around G0S2 on UCSC Golden Path with GeneCards custom track

Promoters for G0S2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000019404 375 1001 HDGF ATF1 MLX CREB3L1 ZNF133 E2F7 FEZF1 ZNF48 YY1 ZNF766

Genomic Location for G0S2 Gene

209,675,325 bp from pter
209,676,390 bp from pter
1,066 bases
Plus strand

Genomic View for G0S2 Gene

Genes around G0S2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
G0S2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for G0S2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for G0S2 Gene

Proteins for G0S2 Gene

  • Protein details for G0S2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G0/G1 switch protein 2
    Protein Accession:
    Secondary Accessions:
    • Q6FGC8

    Protein attributes for G0S2 Gene

    103 amino acids
    Molecular mass:
    11321 Da
    Quaternary structure:
    • Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex.

neXtProt entry for G0S2 Gene

Post-translational modifications for G0S2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for G0S2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for G0S2 Gene

Domains & Families for G0S2 Gene

Protein Domains for G0S2 Gene


Suggested Antigen Peptide Sequences for G0S2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with G0S2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for G0S2 Gene

Function for G0S2 Gene

Molecular function for G0S2 Gene

UniProtKB/Swiss-Prot Function:
Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.
UniProtKB/Swiss-Prot Induction:
Induced by TNF through the activation of the NFKB pathway.

Gene Ontology (GO) - Molecular Function for G0S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 19706769
genes like me logo Genes that share ontologies with G0S2: view
genes like me logo Genes that share phenotypes with G0S2: view

Animal Models for G0S2 Gene

MGI Knock Outs for G0S2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for G0S2 Gene

Localization for G0S2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for G0S2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for G0S2 gene
Compartment Confidence
mitochondrion 5
peroxisome 2
extracellular 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for G0S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA,IEA 19706769
GO:0005811 lipid particle TAS --
genes like me logo Genes that share ontologies with G0S2: view

Pathways & Interactions for G0S2 Gene

genes like me logo Genes that share pathways with G0S2: view

Interacting Proteins for G0S2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)
Selected Interacting proteins: ENSP00000355996 P27469-G0S2_HUMAN for G0S2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for G0S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0019216 regulation of lipid metabolic process TAS --
GO:0097191 extrinsic apoptotic signaling pathway IDA 19706769
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway IDA 19706769
genes like me logo Genes that share ontologies with G0S2: view

No data available for SIGNOR curated interactions for G0S2 Gene

Drugs & Compounds for G0S2 Gene

No Compound Related Data Available

Transcripts for G0S2 Gene

mRNA/cDNA for G0S2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(123) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for G0S2 Gene

G0/G1switch 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for G0S2 Gene

No ASD Table

Relevant External Links for G0S2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for G0S2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for G0S2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for G0S2 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x8.6), Liver (x7.7), Adipose - Subcutaneous (x7.0), Whole Blood (x5.9), and Breast - Mammary Tissue (x5.1).

Protein differential expression in normal tissues from HIPED for G0S2 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for G0S2 Gene

Protein tissue co-expression partners for G0S2 Gene

NURSA nuclear receptor signaling pathways regulating expression of G0S2 Gene:


SOURCE GeneReport for Unigene cluster for G0S2 Gene:


mRNA Expression by UniProt/SwissProt for G0S2 Gene:

Tissue specificity: Widely expressed with highest levels in peripheral blood, skeletal muscle and heart, followed by kidney and liver.

Evidence on tissue expression from TISSUES for G0S2 Gene

  • Lung(4.5)
  • Muscle(3.8)
  • Heart(3.2)
  • Liver(3.2)
  • Bone marrow(2.6)
  • Kidney(2.4)
  • Intestine(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with G0S2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for G0S2 Gene

Orthologs for G0S2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for G0S2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia G0S2 34 35
  • 99.68 (n)
(Bos Taurus)
Mammalia G0S2 34 35
  • 81.63 (n)
(Mus musculus)
Mammalia G0s2 34 16 35
  • 80.91 (n)
(Rattus norvegicus)
Mammalia G0s2 34
  • 78.96 (n)
(Canis familiaris)
Mammalia G0S2 34
  • 78.95 (n)
(Monodelphis domestica)
Mammalia G0S2 35
  • 67 (a)
(Gallus gallus)
Aves GOS2 35
  • 48 (a)
(Anolis carolinensis)
Reptilia G0S2 35
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11119 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.2789 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9214 34
Species where no ortholog for G0S2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for G0S2 Gene

Gene Tree for G0S2 (if available)
Gene Tree for G0S2 (if available)

Paralogs for G0S2 Gene

No data available for Paralogs for G0S2 Gene

Variants for G0S2 Gene

Sequence variations from dbSNP and Humsavar for G0S2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000897849 -- 209,674,777(+) TTTCT(A/G)TCAAC intron-variant, upstream-variant-2KB
rs1001206405 -- 209,676,423(+) GTCCT(A/G)GGGTG intron-variant, upstream-variant-2KB
rs1001703605 -- 209,676,732(+) TTACA(C/T)CTGTG intron-variant, upstream-variant-2KB
rs1001861463 -- 209,674,961(+) CCTTC(C/T)GAATA intron-variant, upstream-variant-2KB
rs1002313207 -- 209,675,450(+) CAGCT(G/T)CCGAG intron-variant, upstream-variant-2KB, utr-variant-5-prime

Variation tolerance for G0S2 Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for G0S2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for G0S2 Gene

Disorders for G0S2 Gene

Relevant External Links for G0S2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for G0S2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for G0S2 Gene

Publications for G0S2 Gene

  1. A human putative lymphocyte G0/G1 switch gene containing a CpG-rich island encodes a small basic protein with the potential to be phosphorylated. (PMID: 1930693) Russell L. … Forsdyke D.R. (DNA Cell Biol. 1991) 2 3 4 64
  2. Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2. (PMID: 19706769) Welch C. … Green M.R. (Cancer Res. 2009) 3 4 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. A preliminary gene map for the Van der Woude syndrome critical region derived from 900 kb of genomic sequence at 1q32-q41. (PMID: 10645953) Schutte B.C. … Murray J.C. (Genome Res. 2000) 2 3 64

Products for G0S2 Gene

Sources for G0S2 Gene

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