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Aliases for G0S2 Gene

Aliases for G0S2 Gene

  • G0/G1 Switch 2 2 3 5
  • Putative Lymphocyte G0/G1 Switch Gene 2 4
  • G0/G1 Switch Regulatory Protein 2 4
  • G0/G1switch 2 2

External Ids for G0S2 Gene

Previous GeneCards Identifiers for G0S2 Gene

  • GC01P208488
  • GC01P205554
  • GC01P206487
  • GC01P206928
  • GC01P206237
  • GC01P207915
  • GC01P209848
  • GC01P180523

Summaries for G0S2 Gene

GeneCards Summary for G0S2 Gene

G0S2 (G0/G1 Switch 2) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Diurnally regulated genes with circadian orthologs.

UniProtKB/Swiss-Prot for G0S2 Gene

  • Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for G0S2 Gene

Genomics for G0S2 Gene

Regulatory Elements for G0S2 Gene

Enhancers for G0S2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around G0S2 on UCSC Golden Path with GeneCards custom track

Promoters for G0S2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around G0S2 on UCSC Golden Path with GeneCards custom track

Genomic Location for G0S2 Gene

209,675,325 bp from pter
209,676,390 bp from pter
1,066 bases
Plus strand

Genomic View for G0S2 Gene

Genes around G0S2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
G0S2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for G0S2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for G0S2 Gene

Proteins for G0S2 Gene

  • Protein details for G0S2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G0/G1 switch protein 2
    Protein Accession:
    Secondary Accessions:
    • Q6FGC8

    Protein attributes for G0S2 Gene

    103 amino acids
    Molecular mass:
    11321 Da
    Quaternary structure:
    • Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex.

neXtProt entry for G0S2 Gene

Proteomics data for G0S2 Gene at MOPED

Post-translational modifications for G0S2 Gene

No Post-translational modifications

Other Protein References for G0S2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for G0S2 Gene

Domains & Families for G0S2 Gene

Protein Domains for G0S2 Gene


Suggested Antigen Peptide Sequences for G0S2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with G0S2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for G0S2 Gene

Function for G0S2 Gene

Molecular function for G0S2 Gene

UniProtKB/Swiss-Prot Function:
Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.
UniProtKB/Swiss-Prot Induction:
Induced by TNF through the activation of the NFKB pathway.

Gene Ontology (GO) - Molecular Function for G0S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with G0S2: view
genes like me logo Genes that share phenotypes with G0S2: view

Animal Models for G0S2 Gene

MGI Knock Outs for G0S2:
  • G0s2 tm1(KOMP)Vlcg

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for G0S2 Gene

Localization for G0S2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for G0S2 Gene


Subcellular locations from

Jensen Localization Image for G0S2 Gene COMPARTMENTS Subcellular localization image for G0S2 gene
Compartment Confidence
mitochondrion 5
cytosol 1
extracellular 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for G0S2 Gene

Pathways & Interactions for G0S2 Gene

genes like me logo Genes that share pathways with G0S2: view

Interacting Proteins for G0S2 Gene

Gene Ontology (GO) - Biological Process for G0S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044255 cellular lipid metabolic process TAS --
GO:0097191 extrinsic apoptotic signaling pathway IDA 19706769
genes like me logo Genes that share ontologies with G0S2: view

No data available for SIGNOR curated interactions for G0S2 Gene

Drugs & Compounds for G0S2 Gene

No Compound Related Data Available

Transcripts for G0S2 Gene

mRNA/cDNA for G0S2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(123) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for G0S2 Gene

G0/G1switch 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for G0S2 Gene

No ASD Table

Relevant External Links for G0S2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for G0S2 Gene

mRNA expression in normal human tissues for G0S2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for G0S2 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x8.6), Liver (x7.7), Adipose - Subcutaneous (x7.0), Whole Blood (x5.9), and Breast - Mammary Tissue (x5.1).

Protein differential expression in normal tissues from HIPED for G0S2 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for G0S2 Gene

SOURCE GeneReport for Unigene cluster for G0S2 Gene Hs.432132

mRNA Expression by UniProt/SwissProt for G0S2 Gene

Tissue specificity: Widely expressed with highest levels in peripheral blood, skeletal muscle and heart, followed by kidney and liver.
genes like me logo Genes that share expression patterns with G0S2: view

Protein tissue co-expression partners for G0S2 Gene

Primer Products

Orthologs for G0S2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for G0S2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia G0S2 35
  • 81.63 (n)
  • 66.33 (a)
G0S2 36
  • 66 (a)
(Canis familiaris)
Mammalia G0S2 35
  • 78.95 (n)
  • 62.11 (a)
(Mus musculus)
Mammalia G0s2 35
  • 80.91 (n)
  • 77.67 (a)
G0s2 16
G0s2 36
  • 78 (a)
(Pan troglodytes)
Mammalia G0S2 35
  • 99.68 (n)
  • 100 (a)
G0S2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia G0s2 35
  • 78.96 (n)
  • 76.7 (a)
(Monodelphis domestica)
Mammalia G0S2 36
  • 67 (a)
(Gallus gallus)
Aves GOS2 36
  • 48 (a)
(Anolis carolinensis)
Reptilia G0S2 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11119 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.2789 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9214 35
Species with no ortholog for G0S2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for G0S2 Gene

Gene Tree for G0S2 (if available)
Gene Tree for G0S2 (if available)

Paralogs for G0S2 Gene

No data available for Paralogs for G0S2 Gene

Variants for G0S2 Gene

Structural Variations from Database of Genomic Variants (DGV) for G0S2 Gene

Variant ID Type Subtype PubMed ID
nsv873139 CNV Gain 21882294

Variation tolerance for G0S2 Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.67% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for G0S2 Gene

Disorders for G0S2 Gene

Relevant External Links for G0S2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for G0S2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for G0S2 Gene

Publications for G0S2 Gene

  1. A human putative lymphocyte G0/G1 switch gene containing a CpG-rich island encodes a small basic protein with the potential to be phosphorylated. (PMID: 1930693) Russell L. … Forsdyke D.R. (DNA Cell Biol. 1991) 2 3 4 67
  2. A preliminary gene map for the Van der Woude syndrome critical region derived from 900 kb of genomic sequence at 1q32-q41. (PMID: 10645953) Schutte B.C. … Murray J.C. (Genome Res. 2000) 2 3
  3. Lipolytic inhibitor G0/G1 switch gene 2 inhibits reactive oxygen species production and apoptosis in endothelial cells. (PMID: 25588877) Wang Y. … Zhang P. (Am. J. Physiol., Cell Physiol. 2015) 3
  4. G0S2 inhibits the proliferation of K562 cells by interacting with nucleolin in the cytosol. (PMID: 24183236) Yamada T. … Lacorazza H.D. (Leuk. Res. 2014) 3
  5. A peptide derived from G0/G1 switch gene 2 acts as noncompetitive inhibitor of adipose triglyceride lipase. (PMID: 25258314) Cerk I.K. … Oberer M. (J. Biol. Chem. 2014) 3

Products for G0S2 Gene

Sources for G0S2 Gene