V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

G0S2 Gene

protein-coding GIFtS: 46

GC01P207915

G0/G1switch 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
OTTHUMP00000034644 ^²
RP1-28O10.2 ^²

Descriptions
G0/G1switch 2 ^²
putative lymphocyte G0/G1 switch ^²

External Ids
HGNC: 30229¹
Entrez Gene: 50486²
UniProtKB: P27469³
Ensembl: ENSG00000123689⁷

Search outside databases for aliases for G0S2 gene

Previous GC identifers: GC01P208488 GC01P205554 GC01P206487 GC01P206928 GC01P206237

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: G0S2_HUMAN, P27469

Function: Potential oncogene and regulator of latent HIV

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the G0S2 gene

Entrez Gene cytogenetic band: 1q32.2|1q32.2-q41 Ensembl cytogenetic band: 1q32.2 HGNC cytogenetic band: 1q32.2-q41

G0S2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P207915: (about GC identifiers)

Start:	207,915,388 bp from pter
End:	207,916,356 bp from pter
Size:	969 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_021877.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: G0S2_HUMAN, P27469 (See protein sequence)

Recommended Name: Putative lymphocyte G0/G1 switch protein 2

Size: 103 amino acids; 11321 Da

REFSEQ proteins: NP_056529.1

ENSEMBL proteins:

ENSP00000355996

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (G0/G1switch 2)
	Human Recombinant Proteins from Abnova (G0S2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--

About this table

Antibodies for G0S2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for G0S2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (G0/G1switch 2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (G0S2)
	Novus Biologicals Antibody for G0S2

Assays for G0S2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P27469

ProtoNet protein and cluster: P27469

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (G0S2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015714

Applied Biosystems Silencer® siRNAs for G0S2

Sigma-Aldrich siRNA for G0S2

Sigma-Aldrich shRNA for G0S2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_015714
Myc/DDK tagged cDNA clone in CMV expression vector: NM_015714
untagged cDNA clone in CMV expression vector: NM_015714

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_015714

UniProtKB/Swiss-Prot: G0S2_HUMAN, P27469

Function: Potential oncogene and regulator of latent HIV

1 MGI phenotypic allele for G0s2 (no phenotypes)

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007049	cell cycle	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for G0S2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (G0S2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015714

Sigma-Aldrich siRNA for G0S2

Sigma-Aldrich shRNA for G0S2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_015714

REFSEQ mRNAs for G0S2 gene:

NM_015714.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_015714

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015714
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_015714
                                 untagged cDNA clone in CMV expression vector: NM_015714

Additional cDNA sequence:

BT007101.1 CR542179.1 CR542193.1

3 DOTS entries:

DT.446083 DT.102822673 DT.102822672

24/123 AceView cDNA sequences (see all 123 ):

BM745941 BT007101 BM129051 BM129218 CR542179 CK819444 AV709160 F30189

CR542193 F35515 BE877213 BG489849 BE873759 BE875715 F22711 BI761176

CB528740 BM788126 BI770259 CA307192 BM820757 CA772104 BE876492 CD370086

highest scoring ESTs for G0S2:

AA193002 AA594415 AA858053 AA918526 AA931758 AA937233 AJ706392 AJ710179 AL036557 AL037277

Unigene Clusters for G0S2:

G0/G1switch 2

Hs.432132 [show with all ESTs], Hs.715825 [show with all ESTs]

Unigene Representative Sequences: BE874862, CD511787

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000367029

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

G0S2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for G0S2

¹ / ² / ³

3 probe-sets matching G0S2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38326_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M69199	0.20	1.00	0.72	1
213524_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_015714	0.60	1.00	0.82	1
213524_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks G0S2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.432132 Hs.715825
Expression variation in blood from EXPOLDB for G0S2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for G0S2 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	G0S2¹	--	G0/G1switch 2	99.68(n) 100(a)	457697 XM_001168111.1 XP_001168111.1
cow (Bos taurus)	G0S2¹	--	G0/G1switch 2	81.63(n) 66.33(a)	507436 XM_584034.3 XP_584034.3
rat (Rattus norvegicus)	G0s2¹	--	G0/G1switch 2	78.96(n) 76.7(a)	289388 NM_001009632.1 NP_001009632.1
mouse (Mus musculus)	G0s2^{1, 5}	1 (104.10 cM)⁵	G0/G1 switch gene 2^{1, 5}	80.58(n)¹ 77.67(a)¹	14373¹ NM_008059.2¹ NP_032085.1¹ AI255151⁵ AK003165⁵ (see all 12)
African clawed frog (Xenopus laevis)	Xl.2789²	--	Xenopus laevis transcribed sequence with weak similarity more	73.4(n)	BG345520.1

About this table Species with no ortholog for G0S2

ENSEMBL Gene Tree for G0S2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/36 NCBI SNPs in G0S2 are shown (see all 36 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 28)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs932374^1,2	A,C,F,H,O	207915055(+)	`GCCATA/GTCAGA`	1	--	ng5¹		4		EU EA WA	412
	rs6694238^1,2	A,C,F,H	207916761(+)	`ACAGAG/CAGACA`	1	--	ng3¹		4		EU EA WA	414
--	rs1473683^1,2	A,C,F,H	207916029(+)	`AGGAAG/TGGAGA`	1	--	ut3¹		5		MN EU EA WA	600
	rs6540547^1,2	C,F,H	207916643(+)	`AGCTAG/CAGTGA`	1	--	ng3¹		8		EU EA WA	836
	rs3817870^1,2	C,F	207915625(+)	`GGTCAT/CTCCCG`	1	--	ut5¹ ese³		1		EA	734
	rs932375^1,2	A	207915319(+)	`GGGCCC/GGAGAG`	1	--	ut5¹		0	--	--	--	--
--	rs3830766^1,2	C	207916023(+)	`CGAGA-/GAGGAA`	1	--	ut3¹ trp³		0	--	--	--	--
--	rs41274832^1,2	--	207915083(+)	`CCCTGA/GGCTCC`	1	--	ng5¹		0	--	--	--	--
--	rs11290686^1,2	--	207916344(+)	`AAAAA-/ACTTTT`	1	--	ut3¹		0	--	--	--	--
	rs1052226^1,2	--	207915999(+)	`GAGACC/GCAGTA`	1	--	ut3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for G0S2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

9 PubMed articles for G0S2 gene:

A human putative lymphocyte G0/G1 switch gene containing a CpG-rich island encodes a small basic protein with the potential to be phosphorylated. (PubMed id 1930693)^{2, 3, 4} Russell L. and Forsdyke D.R. (1991)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A preliminary gene map for the Van der Woude syndrome critical region derived from 900 kb of genomic sequence at 1q32-q41. (PubMed id 10645953)^{2, 3} Schutte B.C....Murray J.C. (2000)
G0S2 is an all-trans-retinoic acid target gene. (PubMed id 18636162)³ Kitareewan S....Dmitrovsky E. (2008)
Transcriptome analysis of human gastric cancer. (PubMed id 16341674)³ Oh J.H....Kim N.S. (2005)
The G0/G1 switch gene 2 is a novel PPAR target gene. (PubMed id 16086669)³ Zandbergen F....Kersten S. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Cyclosporin A inhibits early mRNA expression of G0/G1 switch gene 2 (G0S2) in cultured human blood mononuclear cells. (PubMed id 9428793)³ Cristillo A.D....Forsdyke D.R. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 50486	HGNC: 30229	AceView: G0S2	Ensembl:ENSG00000123689	euGenes: HUgn50486
ECgene: G0S2	H-InvDB: G0S2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for G0S2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for G0S2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for G0S2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for G0S2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for G0S2		Antibodies for G0S2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for G0S2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (G0S2)
	Antibodies (G0S2)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (G0/G1switch 2)
	Antibodies (G0/G1switch 2)

Search OriGene for G0S2

Search Tocris compounds for G0S2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for G0S2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
G0S2 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

G0S2 Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for G0S2

Summaries
for G0S2

Genomic Location
for G0S2

Proteins
for G0S2

Protein Domains/
Families
for G0S2

Gene Function
for G0S2

Pathways & Interactions
for G0S2

Drugs & Compounds
for G0S2

Transcripts
for G0S2

Expression
for G0S2

Orthologs
for G0S2

Paralogs
for G0S2

SNPs/Variants
for G0S2

Disorders & Mutations
for G0S2

Medical News
for G0S2

Publications
for G0S2

Search for G0S2

Genome Databases showing G0S2

Other Databases showing G0S2

Specialized Databases showing G0S2

Licensable Technologies
for G0S2

Services
for G0S2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

G0S2 Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor G0S2

Summariesfor G0S2

Genomic Locationfor G0S2

Proteinsfor G0S2

Protein Domains/Familiesfor G0S2

Gene Functionfor G0S2

Pathways & Interactionsfor G0S2

Drugs & Compoundsfor G0S2

Transcriptsfor G0S2

Expression for G0S2

Orthologsfor G0S2

Paralogsfor G0S2

SNPs/Variantsfor G0S2

Disorders & Mutationsfor G0S2

Medical Newsfor G0S2

Publicationsfor G0S2

Search for G0S2

Genome Databases showing G0S2

Other Databases showing G0S2

Specialized Databases showing G0S2

Licensable Technologiesfor G0S2

Servicesfor G0S2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for G0S2

Summaries
for G0S2

Genomic Location
for G0S2

Proteins
for G0S2

Protein Domains/
Families
for G0S2

Gene Function
for G0S2

Pathways & Interactions
for G0S2

Drugs & Compounds
for G0S2

Transcripts
for G0S2

Expression
for G0S2

Orthologs
for G0S2

Paralogs
for G0S2

SNPs/Variants
for G0S2

Disorders & Mutations
for G0S2

Medical News
for G0S2

Publications
for G0S2

Licensable Technologies
for G0S2

Services
for G0S2