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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FYN Gene

protein-coding   GIFtS: 75
GCID: GC06M111981

FYN Oncogene Related To SRC, FGR, YES

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
FYN Oncogene Related To SRC, FGR, YES1 2     OKT3-Induced Calcium Influx Regulator2
Proto-Oncogene C-Fyn2 3     p59-FYN2
Proto-Oncogene Syn2 3     Src/Yes-Related Novel2
Src-Like Kinase2 3     Tyrosine Kinase P59fyn(T)2
SLK2 3     Tyrosine-Protein Kinase Fyn2
EC 2.7.10.23 8     p59-Fyn3
SYN2     EC 2.7.108
C-Syn Protooncogene2     

External Ids:    HGNC: 40371   Entrez Gene: 25342   Ensembl: ENSG000000108107   OMIM: 1370255   UniProtKB: P062413   

Export aliases for FYN gene to outside databases

Previous GC identifers: GC06M111817 GC06M112005 GC06M112028 GC06M112089 GC06M109555


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FYN Gene:
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine
kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of
phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript
variants encoding distinct isoforms exist. (provided by RefSeq, Jul 2008)

GeneCards Summary for FYN Gene: 
FYN (FYN oncogene related to SRC, FGR, YES) is a protein-coding gene. Diseases associated with FYN include alexia, and lymphopenia, and among its related super-pathways are Development Slit-Robo signaling and Immune response Fc epsilon RI pathway. GO annotations related to this gene include ion channel binding and identical protein binding. An important paralog of this gene is FRK.

UniProtKB/Swiss-Prot: FYN_HUMAN, P06241
Function: Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation
of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility,
immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic
domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1
phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and
motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal
remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated
proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic
cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit
diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm
components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a
multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases
implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream
signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR)
stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1,
thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and
FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1

summary for FYN Gene:
Src kinases consist of eight non-receptor tyrosine kinases (Src, Fyn, Yes, Lck, Lyn, Hck, Fgr and Blk) that
interact with the intracellular domains of growth factor/cytokine receptors, GPCRs and integrins. Members of
the Src kinase family have a very similar domain structure with a high degree of homology in the SH1
(catalytic), linker, SH2 (p-Tyr binding), SH3 (protein-protein interaction) and SH4 (membrane association)
domains. c-Src, Fyn and Yes are ubiquitously expressed, although high levels of c-Src are found in
platelets, neural tissue and osteoclasts. For c-Src, autophosphorylation of Tyr418 and dephosphorylation of
Tyr530 is required to switch the kinase from the inactive closed formation to the active open formation.
c-Src can be inactivated by two kinases, c-Src kinase (CSK) and CSK homologous kinase (CHK), both of which
phosphorylate Tyr530 of c-Src. The activity of the Src kinase family can also be regulated by phosphatases
(e.g. SHP1), binding to adaptor proteins (e.g. Cbp) and proteasomal degradation. Src kinases are key
upstream mediators of both the PI 3-K and MAPK signaling pathways, and have been shown to have important
roles in cell proliferation, migration and survival.

Gene Wiki entry for FYN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FYN gene promoter:
         AP-1   ATF-2   STAT5A   c-Jun   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): FYN promoter sequence
   Search SABiosciences Chromatin IP Primers for FYN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FYN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

FYN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FYN gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M111981:  view genomic region     (about GC identifiers)

Start:
111,981,535 bp from pter      End:
112,194,655 bp from pter
Size:
213,121 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FYN_HUMAN, P06241 (See protein sequence)
Recommended Name: Tyrosine-protein kinase Fyn  
Size: 537 amino acids; 60762 Da
Cofactor: Manganese
Subunit: Interacts (via its SH3 domain) with PIK3R1 and PRMT8. Interacts with FYB, PAG1, and SH2D1A. Interacts
with CD79A (tyrosine-phosphorylated form); the interaction increases FYN activity. Interacts (via SH2 domain)
with CSF1R (tyrosine phosphorylated) (By similarity). Interacts with TOM1L1 (phosphorylated form). Interacts with
KDR (tyrosine phosphorylated). Interacts (via SH3 domain) with KLHL2 (via N-terminus) (By similarity). Interacts
with SH2D1A and SLAMF1. Interacts (via its SH3 domain) with HEV ORF3 protein. Interacts with ITCH; the
interaction phosphorylates ITCH and negatively regulates its activity. Interacts with FASLG. Interacts with
RUNX3. Interacts with KIT. Interacts with EPHA8; possible downstream effector of EPHA8 in regulation of cell
adhesion. Interacts with PTK2/FAK1; this interaction leads to PTK2/FAK1 phosphorylation and activation. Interacts
with CAV1; this interaction couples integrins to the Ras-ERK pathway
Subcellular location: Cytoplasm. Nucleus. Cell membrane. Note=Present and active in lipid rafts. Palmitoylation is
crucial for proper trafficking
6/21 PDB 3D structures from and Proteopedia for FYN (see all 21):
1A0N (3D)        1AOT (3D)        1AOU (3D)        1AVZ (3D)        1AZG (3D)        1EFN (3D)    
Secondary accessions: B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7
Alternative splicing: 3 isoforms:  P06241-1   P06241-2   P06241-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FYN: NX_P06241

Explore proteomics data for FYN at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated at Tyr-420. Phosphorylation on the C-terminal tail at Tyr-531 by CSK maintains the enzyme in an
    inactive state (By similarity). PTPRC/CD45 dephosphorylates Tyr-531 leading to activation. ultraviolet B (UVB)
    strongly increase phosphorylation at Thr-12 and kinase activity, and promotes translocation from the cytoplasm to
    the nucleus
  • UniProtKB: Palmitoylation at Cys-3 and Cys-6 regulates subcellular location (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P06241

  • 4/41 DME Specific Peptides for FYN (P06241) (see all 41)
     DNGGYYI  KWTAPEA  FLEDYFT  FLIRESE 

    FYN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FYN Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_002028.1  NP_694592.1  NP_694593.1  

    ENSEMBL proteins: 
     ENSP00000357671   ENSP00000346671   ENSP00000229471   ENSP00000357656   ENSP00000357667  
     ENSP00000427993   ENSP00000429294   ENSP00000429866   ENSP00000428695   ENSP00000430364  
     ENSP00000428493   ENSP00000429992   ENSP00000429590   ENSP00000429813   ENSP00000428045  
     ENSP00000428983   ENSP00000428042   ENSP00000430455   ENSP00000229470   ENSP00000348295  
     ENSP00000440646  
    Reactome Protein details: P06241
    Human Recombinant Protein Products for FYN: 
    EMD Millipore Purified and/or Recombinant FYN Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for FYN
    OriGene Purified Proteins for FYN
    OriGene Protein Over-expression Lysate for FYN
    OriGene MassSpec for FYN 
    OriGene Custom Protein Services for FYN
    GenScript Custom Purified and Recombinant Proteins Services for FYN
    Novus Biologicals FYN Proteins
    Novus Biologicals FYN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for FYN
    Cloud-Clone Corp. Proteins for FYN 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion IEA--
    GO:0005768endosome IDA15611048
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA15611048

    FYN for ontologies           About GeneDecksing



    FYN Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of FYN
    R&D Systems Antibodies for FYN
    Cell Signaling Technology (CST) Antibodies for FYN 
    OriGene Antibodies for FYN
    OriGene Custom Antibody Services for FYN
    GenScript Custom Superior Antibodies Services for FYN
    Novus Biologicals FYN Antibodies
    Abcam antibodies for FYN
    Cloud-Clone Corp. Antibodies for FYN 
    ThermoFisher Antibody for FYN
    LSBio Antibodies in human, mouse, rat for FYN 

    Assay Products for FYN: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FYN
    R&D Systems Proteome Profiler Antibody Arrays for FYN
    GenScript FYN-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FYN 
    Cloud-Clone Corp. CLIAs for FYN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: FYN oncogene related to SRC, FGR, YES 
    Src family

    5/8 InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR001452 SH3_domain
     IPR000719 Prot_kinase_cat_dom
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P06241

    ProtoNet protein and cluster: P06241

    3 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: FYN_HUMAN, P06241
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    FYN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FYN_HUMAN, P06241
    Function: Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation
    of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility,
    immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic
    domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1
    phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and
    motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal
    remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated
    proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic
    cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit
    diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm
    components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a
    multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases
    implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream
    signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR)
    stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1,
    thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and
    FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by
    dephosphorylation of this site

         Genatlas biochemistry entry for FYN:
    SRC/YES-related oncogene homolog,involved in T cell signaling regulation,STAR (signal transduction and activator
    of RNA) family

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): 5/19 molecular function terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding IPI16831868
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity TAS--
    GO:0004715non-membrane spanning protein tyrosine kinase activity NAS7822789
    GO:0005102receptor binding ----
         
    FYN for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for FYN:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased colony dispersion (i 

         15 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Fyn):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  nervous system 
     no phenotypic analysis  renal/urinary system  reproductive system  taste/olfaction  vision/eye 

    FYN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FYN: Fyntm1Sor Fyntm1Rmp Fyntm1Fam

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FYN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FYN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FYN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FYN 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FYN
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate FYN (see all 11):
    hsa-miR-429 hsa-miR-125a-3p hsa-miR-4251 hsa-miR-586 hsa-miR-1271 hsa-miR-583 hsa-miR-200c hsa-miR-369-3p
    SwitchGear 3'UTR luciferase reporter plasmidFYN 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FYN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FYN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FYN
    Sirion Biotech Customized adenovirus for overexpression of FYN

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FYN (see all 20)
    OriGene ORF clones in mouse, rat for FYN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FYN (NM_153047)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FYN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FYN
    Sirion Biotech Customized lentivirus for stable overexpression of FYN 
                         Customized lentivirus expression plasmids for stable overexpression of FYN 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FYN
    Search LifeMap BioReagents cell lines for FYN
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FYN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FYN About   (see all 107)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development Slit-Robo signaling
    Development Slit-Robo signaling0.92
    Pathogenic Escherichia coli infection0.43
    Cytoskeleton remodeling Slit-Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    2Immune response Fc epsilon RI pathway
    Fc epsilon RI signaling pathway0.40
    Immune response Role of DAP12 receptors in NK cells0.32
    Fc-epsilon receptor I signaling in mast cells0.33
    Natural killer cell mediated cytotoxicity0.31
    3CD28 co-stimulation
    CD28 co-stimulation0.66
    CD28 dependent Vav1 pathway0.38
    CD28 dependent PI3K/Akt signaling0.66
    CTLA4 Signaling0.31
    Costimulation by the CD28 family0.41
    4Focal Adhesion
    Focal Adhesion0.64
    Integrin-mediated cell adhesion0.38
    Focal adhesion0.64
    5Development Prolactin receptor signaling
    Development Prolactin receptor signaling0.39
    Leptin signaling pathway0.35
    Prolactin Signaling Pathway0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/15 EMD Millipore Pathways for FYN (see all 15)
        G-protein signaling Regulation of CDC42 activity
    Chemotaxis CXCR4 signaling pathway
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Immune response Role of DAP12 receptors in NK cells
    Cytoskeleton remodeling Slit-Robo signaling

    1 R&D Systems Pathway for FYN
        VEGF - VEGF R2 Signaling Pathways

    5/26 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FYN (see all 26)
        Calcium Mediated T-Cell Apoptosis
    Remodeling of Adherens Junctions
    Guidance Cues and Growth Cone Motility
    Molecular Mechanisms of Cancer
    Semaphorin Signaling

    2 Cell Signaling Technology (CST) Pathways for FYN
        MAP Kinase Signaling
    Tyrosine Kinases / Adaptors

    5/16 GeneGo (Thomson Reuters) Pathways for FYN (see all 16)
        Immune response CD28 signaling
    G-protein signaling Regulation of CDC42 activity
    Chemotaxis CXCR4 signaling pathway
    Development Slit-Robo signaling
    Immune response T cell receptor signaling pathway

    5/40 BioSystems Pathways for FYN (see all 40)
        Focal Adhesion
    Integrin-mediated cell adhesion
    BDNF signaling pathway
    IL-4 signaling Pathway
    Kit Receptor Signaling Pathway

    5/66        Reactome Pathways for FYN (see all 66)
        CRMPs in Sema3A signaling
    Nephrin interactions
    Signaling by PDGF
    Downstream Signaling Events Of B Cell Receptor (BCR)
    Signalling by NGF


    5/12         Kegg Pathways  (Kegg details for FYN) (see all 12):
        Axon guidance
    Osteoclast differentiation
    Focal adhesion
    Adherens junction
    Natural killer cell mediated cytotoxicity


    FYN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FYN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/595 Interacting proteins for FYN (P062411, 2, 3 ENSP000003576564) via UniProtKB, MINT, STRING, and/or I2D (see all 595)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED28Q9H2041, 2, 3, ENSP000002373804EBI-515315,EBI-514199 MINT-7041679 I2D: score=4 STRING: ENSP00000237380
    ABL2P426841, 2, 3, ENSP000003565954EBI-515315,EBI-1102694 MINT-8110899 I2D: score=3 STRING: ENSP00000356595
    CD2P067292, 3, ENSP000003584904MINT-50661 MINT-50664 MINT-50663 MINT-50665 I2D: score=5 STRING: ENSP00000358490
    WASP427682, 3, ENSP000003658914MINT-50146 MINT-50144 MINT-14847 MINT-50145 I2D: score=4 STRING: ENSP00000365891
    PAG1Q9NWQ82, 3, ENSP000002205974MINT-8032868 MINT-8034123 MINT-8034138 MINT-8032853 I2D: score=3 STRING: ENSP00000220597
    About this table

    Gene Ontology (GO): 5/38 biological process terms (GO ID links to tree view) (see all 38):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0006468protein phosphorylation NAS7822789
    GO:0006816calcium ion transport NAS7822789
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007173epidermal growth factor receptor signaling pathway TAS--

    FYN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FYN for compounds           About GeneDecksing

    EMD Millipore small molecules for FYN:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for FYN

    Compounds for FYN available from Tocris Bioscience    About this table
    CompoundAction CAS #
    1-Naphthyl PP1Src family kinase inhibitor; also inhibits c-Abl[221243-82-9]
    PP 2 Potent, selective Src family kinase inhibitor [172889-27-9]
    PP 3Negative control for PP 2 (Cat. No. 1407)[5334-30-5]
    BosutinibDual Src-Abl inhibitor; antiproliferative[380843-75-4]
    PP 1 Potent, selective Src family kinase inhibitor [172889-26-8]

    4 HMDB Compounds for FYN    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    Manganesemanganese 7439-96-5--

    2 DrugBank Compounds for FYN    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Dasatinib-- 302962-49-8targetmultitarget17139284 20072833 11752352 17016423
    1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane-- --target--10592235

    10/53 Novoseek inferred chemical compound relationships for FYN gene (see all 53)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 89.5 600 9104812 (6), 1465444 (6), 9535867 (4), 10838156 (4) (see all 99)
    phosphotyrosine 73.1 13 7524477 (1), 12654250 (1), 1383216 (1), 11063873 (1) (see all 10)
    herbimycin a 67.6 3 9049148 (1), 7543423 (1), 10871840 (1)
    phosphatidylinositol 65.7 41 10848967 (5), 1465444 (3), 7642581 (2), 1328986 (1) (see all 30)
    4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine 54.1 1 18632659 (1)
    happ 45.2 14 15140940 (4), 16237174 (3)
    threonine 44.2 4 1699196 (1), 17098432 (1), 9155022 (1)
    piceatannol 40.4 2 10528214 (1), 11154209 (1)
    serine 38.7 9 12721299 (1), 17098432 (1), 8413237 (1), 8227079 (1) (see all 7)
    calcium 35.6 26 7621861 (3), 10964479 (2), 8500615 (2), 11776298 (1) (see all 19)

    Search CenterWatch for drugs/clinical trials and news about FYN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FYN gene (4 alternative transcripts): 
    NM_002037.5  NM_153047.3  NM_153048.3  NM_001242779.1  

    Unigene Cluster for FYN:

    FYN oncogene related to SRC, FGR, YES
    Hs.390567  [show with all ESTs]
    Unigene Representative Sequence: BX537571
    18/31 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):
    ENST00000368682(uc003pvh.3 uc003pvi.3) ENST00000354650(uc003pvj.3 uc003pvk.3)
    ENST00000229471(uc010kdy.1) ENST00000368667 ENST00000368678 ENST00000491885
    ENST00000467921 ENST00000471959 ENST00000496864 ENST00000476769 ENST00000495935
    ENST00000467899 ENST00000495927 ENST00000523322 ENST00000462856 ENST00000520518
    ENST00000517419 ENST00000518295
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB451293.1 AB451426.1 AK056699.1 AY429536.1 BC032496.1 BX537571.1 M14333.1 M14676.1 
    S74774.1 

    22 DOTS entries:

    DT.86843886  DT.95289422  DT.121321013  DT.95132434  DT.75101275  DT.92435837  DT.121320911  DT.100880796 
    DT.121320926  DT.121320948  DT.100687227  DT.100880804  DT.100880805  DT.95264558  DT.100880806  DT.121320940 
    DT.121320982  DT.95131340  DT.100880803  DT.436784  DT.75198251  DT.86800269 

    24/304 AceView cDNA sequences (see all 304):

    BX099778 AI150708 NM_153047 BM738560 BM724842 CB162527 BI763851 AI498268 
    AI650971 BF931843 BF939725 F03232 AU141939 R39866 AA894844 N44762 
    AL134258 AU185836 BC032496 H46981 BI468586 BI552534 BF593649 AI493204 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FYN expression in normal human tissues (normalized intensities)      FYN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTAACAAA
    FYN Expression
    About this image


    FYN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/25 selected tissues (see all 25) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
             ganglion/cranial   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   

    See FYN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FYN

    SOURCE GeneReport for Unigene cluster: Hs.390567

    UniProtKB/Swiss-Prot: FYN_HUMAN, P06241
    Tissue specificity: Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic
    lineages, especially T-lymphocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including FYN: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FYN gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fyn1 , 5 Fyn proto-oncogene1, 5 93.23(n)1
    99.44(a)1
      10 (20.51 cM)5
    143601  NM_001122893.11  NP_001116365.11 
     393688555 
    chicken
    (Gallus gallus)
    Aves FYN1 FYN oncogene related to SRC, FGR, YES 81.59(n)
    92.88(a)
      396294  NM_205349.1  NP_990680.1 
    lizard
    (Anolis carolinensis)
    Reptilia FYN6
    --
    Uncharacterized protein
    99(a)
    79(a)
    1 ↔ 1
    possible ortholog
    1(192360997-192397398)
    GL343464.1(630926-647703)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC043749.12   -- 82.19(n)    BC043749.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fynb1 FYN oncogene related to SRC, FGR, YES b 77.9(n)
    91.81(a)
      574422  NM_001029969.1  NP_001025140.1 
    worm
    (Caenorhabditis elegans)
    Secernentea src-11 , 3 Expression: vulva, anus, mu_bod,
    pharyngeal muscle, more3
    Protein SRC-11
    48(a)
    (best of 4)3
    54.21(n)1
    52.41(a)1
      I(1567610-1580076)3
    1717221  NM_058465.41  NP_490866.41 


    ENSEMBL Gene Tree for FYN (if available)
    TreeFam Gene Tree for FYN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FYN gene
    FRK2  LCK2  BLK2  LYN2  ITK2  TXK2  YES12  HCK2  
    ABL12  BMX2  ABL22  SRMS2  TEC2  FGR2  PTK62  SRC2  
    BTK2  
    18/68 SIMAP similar genes for FYN using alignment to 17 protein entries:     FYN_HUMAN (see all proteins) (see all similar genes):
    NCK1    HCK    SRC    YES1    NCK2    BLK
    LYN    LCK    ABL1    FRK    EPHA2    ITSN2
    EPHA3    EPHA4    EPHA6    EPHA5    FGR    EPHA7

    FYN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3995 SNPs in FYN are shown (see all 3995)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0417044
    A lung squamous cell carcinoma sample4--see VAR_0417042 V L mis40--------
    VAR_0417054
    A metastatic melanoma sample4--see VAR_0417052 G R mis40--------
    rs624206101,2
    C,F--111981098(+) CCAGGC/TGTGGA 3 -- ds50012Minor allele frequency- T:0.04NA 122
    rs1865899181,2
    --111981151(+) GTTGTC/TGCTCC 3 -- ds50010--------
    rs1914281641,2
    --111981265(+) GGACAC/TAGTAA 3 -- ds50010--------
    rs1846786471,2
    --111981275(+) AATTCC/TGGTTA 3 -- ds50010--------
    rs94877021,2
    C,H--111981349(+) AATAGC/TTGGTC 3 -- ds50015Minor allele frequency- T:0.00NS EA 600
    rs1895152991,2
    --111981366(+) CTACCC/TTTTCT 3 -- ds50010--------
    rs752887241,2
    C,F--111981374(+) TCTAGA/GGGGAA 3 -- ds50011Minor allele frequency- G:0.02NA 120
    rs1431819071,2
    C--111981412(+) TCTGTC/TATTTG 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for FYN (111981535 - 112194655 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FYN:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2662755CNV Deletion23128226
    nsv5444CNV Insertion18451855
    esv271837CNV Insertion20981092
    nsv5445CNV Loss18451855
    esv2752088CNV Gain17911159

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 137025    OMIM disorders: --

    20/62 diseases for FYN (see all 62):    About MalaCards
    alexia    lymphopenia    hepatitis e    wiskott-aldrich syndrome
    estrogen-receptor negative breast cancer    focal segmental glomerulosclerosis    prion disease    cblc
    proteinuria    brain ischemia    tauopathy    pharyngitis
    fibrosarcoma    skin cancer    human t-cell leukemia virus type 1    cleft lip
    myocarditis    alcoholism    alcohol dependence    conjunctivitis

    2 diseases from the University of Copenhagen DISEASES database for FYN:
    Cancer     Alzheimer's disease

    FYN for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/33 Novoseek inferred disease relationships for FYN gene (see all 33)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 49 3 8810341 (1), 10532312 (1), 20484117 (1)
    neurofibrillary tangles 30.4 2 15708437 (2)
    leukemia t-cell 18.8 1 9045636 (1)
    alzheimers disease 13.7 8 15098360 (2), 8388744 (1), 16237174 (1), 15082191 (1) (see all 6)
    atrophy 4.76 2 8562954 (1)
    colon cancer 4.6 1 18805444 (1)
    shock 3.06 1 9155022 (1)
    glioblastoma 2.37 6 15994925 (2), 19690143 (1)
    asthma 2.36 2 17703099 (2)
    lymphoma t-cell 2.14 1 11453661 (1)

    Genetic Association Database (GAD): FYN
    Human Genome Epidemiology (HuGE) Navigator: FYN (26 documents)
    Tumor Gene Database (TGDB): FYN

    Export disorders for FYN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FYN gene, integrated from 9 sources (see all 921):
    (articles sorted by number of sources associating them with FYN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family. (PubMed id 3526330)1, 2, 3 Semba K.... Toyoshima K. (1986)
    2. p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn. (PubMed id 12788081)1, 2, 9 Taniguchi S....Yamamoto T. (2003)
    3. In vivo phosphorylation and membrane association of the fyn proto- oncogene product in IM-9 human lymphoblasts. (PubMed id 1699196)1, 2, 9 Peters D.J.... Laudano A.P. (1990)
    4. Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125. (PubMed id 11162638)1, 2, 9 Nakamura T....Nakamura S. (2001)
    5. Fyn phosphorylates human MAP-2c on tyrosine 67. (PubMed id 15536091)1, 2, 9 Zamora-Leon S.P....Shafit-Zagardo B. (2005)
    6. Regulation of TRPC6 channel activity by tyrosine phosphorylation. (PubMed id 14761972)1, 2, 9 Hisatsune C....Mikoshiba K. (2004)
    7. Mutation and association analysis of the Fyn kinase gene with alcoholism and schizophrenia. (PubMed id 11121167)1, 4, 9 Ishiguro H....Arinami T. (2000)
    8. Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity. (PubMed id 10498895)1, 2, 9 Choi S. and Park S. (1999)
    9. Association analysis of tyrosine kinase FYN gene polymorphisms in asthmatic children. (PubMed id 17703099)1, 4, 9 Szczepankiewicz A....Hauser J. (2008)
    10. [Analysis of the fyn kinase gene in Alzheimer's disease and schizophrenia] (PubMed id 15098360)1, 4, 9 Nakano Y....Nanko S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2534 HGNC: 4037 AceView: FYN Ensembl:ENSG00000010810 euGenes: HUgn2534
    ECgene: FYN Kegg: 2534 H-InvDB: FYN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FYN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FYN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FYN gene:
    Search GeneIP for patents involving FYN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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