V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

FYN Gene

protein-coding GIFtS: 75

GC06M112089

FYN oncogene related to SRC, FGR, YES
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.10.2 ^³
MGC45350 ^¹, ²
OTTHUMP00000017914 ^²
OTTHUMP00000017915 ^²
OTTHUMP00000017917 ^²
SLK ^¹, ², ³
SYN ^¹, ²
p59-Fyn ^³

Descriptions
FYN oncogene related to SRC, FGR, YES ^²
OKT3-induced calcium influx regulator ^²
Protooncogene Syn ^³
c-syn protooncogene ^²
protein-tyrosine kinase fyn ^²
proto-oncogene tyrosine-protein kinase fyn ^²
src-like kinase ^²
src/yes-related novel ^²
tyrosine kinase p59fyn(T) ^²

External Ids
HGNC: 4037¹
Entrez Gene: 2534²
UniProtKB: P06241³
Ensembl: ENSG00000010810⁷

Search outside databases for aliases for FYN gene

Previous GC identifers: GC06M111817 GC06M112005 GC06M112028

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FYN:

This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a

membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The

protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the

fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.

[provided by RefSeq]

UniProtKB/Swiss-Prot: FYN_HUMAN, P06241

Function: Implicated in the control of cell growth. Plays a role in the regulation of intracellular

calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in

comparison to isoform 1. Required in brain development and mature brain function with important

roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon

outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC

Gene Wiki entry for FYN

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FYN gene

Entrez Gene cytogenetic band: 6q21 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q21

FYN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M112089: (about GC identifiers)

Start:	112,089,178 bp from pter
End:	112,301,320 bp from pter
Size:	212,143 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000006.10 NT_025741.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FYN_HUMAN, P06241 (See protein sequence)

Recommended Name: Proto-oncogene tyrosine-protein kinase Fyn

Size: 537 amino acids; 60762 Da

Cofactor: Manganese

Subunit: Associates through its SH3 domain, to the p85 subunit of phosphatidylinositol 3-kinase.

Interacts with the FYN-binding protein (FYB). Interacts with phosphorylated TOM1L1. Interacts with

CD79A upon activation of the B-cell antigen receptor which increases FYN activity (By similarity).

Interacts with PAG1. Interacts (via SH3 domain) with PRMT8. Interacts with SH2D1A and SLAMF1.

Interacts (via SH3 domain) with HEV ORF3 protein

Subcellular location: Cell membrane. Note=Present and active in lipid rafts. Present in cell body

and along the process of mature and developing oligodendroyctes

PDB structures from and Proteopedia :

1A0N (3D)

1AOT (3D)

1AOU (3D)

1AVZ (3D)

1AZG (3D)

1EFN (3D)

1FYN (3D)

1G83 (3D)

1M27 (3D)

1NYF (3D)

1NYG (3D)

1SHF (3D)

1ZBJ (3D)

2DQ7 (3D)

Secondary accessions: Q16248 Q5R3A6 Q5R3A7 Q8N5D7

Alternative splicing: 3 isoforms: P06241-1 P06241-2 P06241-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_002028.1 NP_694592.1 NP_694593.1

ENSEMBL proteins:

ENSP00000357667 ENSP00000357671 ENSP00000229470 ENSP00000348295 ENSP00000229471 ENSP00000357656

ENSP00000346671

Human Recombinant Proteins

	Invitrogen human recombinant proteins for FYN
	Millipore Purified and/or Recombinant FYN Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for FYN
	Recombinant Proteins from Abcam (Fyn)
	Human Recombinant Proteins from Abnova (FYN)

OriGene Purified Recombinant Human Proteins (see all 3): FYN

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005768	endosome	IDA	15611048
GO:0005829	cytosol	EXP	10858437
GO:0005886	plasma membrane	IDA	15611048

About this table

Antibodies for FYN:

	Invitrogen Antibodies for FYN
	Millipore Mono- and Polyclonal Antibodies for the study of FYN
	Sigma-Aldrich Antibodies for FYN
	R&D Systems Antibodies for FYN
	Cell Signaling Technology (CST) Antibodies for FYN
	Antibodies from Abcam (Fyn), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FYN)
	Novus Biologicals Antibodies for FYN

Assays for FYN:

	Invitrogen Assays for FYN
	Millipore Kits and Assays for the Analysis of FYN
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P06241

ProtoNet protein and cluster: P06241

3 Blocks protein families:

IPB000980 SH2 domain signature

IPB001452 SH3 domain signature

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: FYN_HUMAN, P06241

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 SH2 domain

Similarity: Contains 1 SH3 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FYN)
		Millipore RNAi Products for the Analysis of FYN Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (FYN)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002037

Applied Biosystems Silencer® siRNAs for FYN

Sigma-Aldrich siRNA and siRNA Panels for FYN

Sigma-Aldrich shRNA Panels and shRNA for FYN

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FYN
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_002037
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_002037
untagged cDNA clones in CMV expression vector (see all 4): NM_002037

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002037

UniProtKB/Swiss-Prot: FYN_HUMAN, P06241

Function: Implicated in the control of cell growth. Plays a role in the regulation of intracellular

calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in

comparison to isoform 1. Required in brain development and mature brain function with important

roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon

outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme regulation: Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and

activated by dephosphorylation of this site

Enzyme Number (IUBMB): EC 2.7.10.2

Genatlas biochemistry entry for FYN:

SRC/YES-related oncogene homolog,involved in T cell signaling regulation,STAR (signal transduction

and activator of RNA) family

15/16 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Fyn) (see all 16 ):

behavior/neurological	endocrine/exocrine gland	growth/size	hearing/vestibular/ear	hematopoietic system
homeostasis/metabolism	immune system	lethality-postnatal	life span-post-weaning/aging	nervous system
no phenotypic analysis	renal/urinary system	reproductive system	skin/coat/nails	taste/olfaction

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0001948	glycoprotein binding	IPI	16831868
GO:0004715	non-membrane spanning protein tyrosine kinase activity	NAS	7822789
GO:0005524	ATP binding	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/20 Sigma-Aldrich "Your Favorite Gene" Pathways for FYN (Your Favorite Gene powered by Ingenuity) (see all 20 )

Axonal Guidance Signaling
Natural Killer Cell Signaling
Virus Entry via Endocytic Pathways
G-Protein Coupled Receptor Signaling
ERK/MAPK Signaling

GeneDecks FYN for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for FYN

5/406 Interacting proteins for FYN (ENSP00000357656³ P06241^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 406 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABL1	P00519¹	STRING (score=.929) EBI-515315, EBI-375543
BCAR1	P56945¹	STRING (score=.991) EBI-515315, EBI-702093
CD2AP	Q9Y5K6¹	STRING (score=.783) EBI-515315, EBI-298152
DAG1	Q14118¹	STRING (score=.802) EBI-515315, EBI-1755945
GP6	Q9HCN6¹	STRING (score=.971) EBI-515315, EBI-515278

About this table

5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	NAS	7822789
GO:0006816	calcium ion transport	NAS	7822789
GO:0007243	protein kinase cascade	TAS	1361685
GO:0007275	multicellular organismal development	IEA	--
GO:0007612	learning	TAS	1361685

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for FYN

Browse Small Molecules at Sigma-Aldrich

Compounds for FYN available from Tocris Bioscience

Compound	Action	CAS number
1-Naphthyl PP1	Src family kinase inhibitor; also inhibits c-Abl	[221243-82-9]

About this table

10/31 Novoseek chemical compound relationships for FYN gene (see all 31 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	89.59	580	9104812 (6), 1465444 (6), 9535867 (4), 10838156 (4) (see all 99)
phosphotyrosine	72.92	12	7524477 (1), 12654250 (1), 1383216 (1), 11063873 (1) (see all 9)
phosphatidylinositol	66.08	39	10848967 (5), 1465444 (3), 7642581 (2), 1328986 (1) (see all 28)
4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine	54.91	1	18632659 (1)
happ	47.23	14	15140940 (4), 16237174 (3)
threonine	43.47	4	1699196 (1), 17098432 (1), 9155022 (1)
piceatannol	42.17	2	10528214 (1), 11154209 (1)
digitonin	36.65	2	9193654 (1), 1506682 (1)
calcium	35.07	26	7621861 (3), 10964479 (2), 8500615 (2), 11776298 (1) (see all 19)
phosphoinositide	31.16	6	12871380 (1), 9794375 (1), 15634346 (1), 18636972 (1) (see all 6)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FYN)
		Millipore RNAi Products for the Analysis of FYN Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (FYN)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002037

Sigma-Aldrich siRNA and siRNA Panels for FYN

Sigma-Aldrich shRNA Panels and shRNA for FYN

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002037 NM_153047 NM_153048

REFSEQ mRNAs for FYN gene (3 alternative transcripts):

NM_002037.3 NM_153047.1 NM_153048.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002037 NM_153047 NM_153048

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_002037
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_002037
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_002037

Additional cDNA sequence:

AB451293.1 AB451426.1 AK056699.1 AK090692.1 AK097134.1 AY429536.1 BC032496.1 BX537571.1

M14333.1 M14676.1 S74774.1

24/32 DOTS entries (see all 32 ):

DT.86843886 DT.95289422 DT.92435837 DT.95132434 DT.121320948 DT.75101275 DT.95264558 DT.121321042

DT.424307 DT.121320911 DT.121320995 DT.436784 DT.91802035 DT.100880796 DT.121321045 DT.100744689

DT.121320926 DT.100880804 DT.100880805 DT.86800269 DT.92435828 DT.95131340 DT.100707610 DT.100880803

24/304 AceView cDNA sequences (see all 304 ):

BF931843 NM_153048 BQ889903 BF939725 N44762 BE221421 Z42062 F03232

M14333 CB215723 AA894844 AI150708 BM724842 BI763851 AI650971 AY429536

CB156965 AI687609 BF593649 T28525 AI498268 H46981 BU741472 CB161968

highest scoring ESTs for FYN:

M14333 AA749232 AI239995 AI476651 AI498268 AW028899 AW131781 AW418644 BE041606 BE221421

Unigene Cluster for FYN:

FYN oncogene related to SRC, FGR, YES

Hs.390567 [show with all ESTs]

Unigene Representative Sequence: BX537571

GeneLoc Exon Structure

7 Ensembl transcripts including schematic representations:

ENST00000368678 ENST00000368682 ENST00000229470 ENST00000356013 ENST00000229471 ENST00000368667

ENST00000354650

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FYN expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FYN

¹ / ² / ³

7 probe-sets matching FYN gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40480_s_at²^{, 3}	U95-A	1	1.00	1.00	0.99	1.12	M14333	1.00	1.00	1.00	1
2039_s_at²^{, 3}	U95-A	1	1.00	1.00	0.98	1.23	M14333	1.00	1.00	1.00	1
40479_at*²^{, 3}	U95-A	1	--	--	0.97	0.66	Z97989	0.20	1.00	0.72	1
210105_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M14333	1.00	1.00	1.00	1
216033_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	S74774	0.60	1.00	0.82	1
210105_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216033_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks FYN for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTTTAACAAA

SOURCE GeneReport for Unigene cluster: Hs.390567
Expression variation in blood from EXPOLDB for FYN
UniProtKB/Swiss-Prot: FYN_HUMAN, P06241
Tissue specificity: Isoform 1 is highly expressed in the brain, isoform 2 is expressed in cells of
hemopoietic lineages, especially T lymphocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FYN gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FYN¹	--	FYN oncogene related to SRC, FGR, YES	88.89(n) 93.45(a)	475032 XM_863422.1 XP_868515.1
chimpanzee (Pan troglodytes)	FYN¹	--	FYN oncogene related to SRC, FGR, YES	99.13(n) 98.88(a)	462944 XM_001158524.1 XP_001158524.1
cow (Bos taurus)	FYN¹	--	FYN oncogene related to SRC, FGR, YES	94.54(n) 99.63(a)	527263 XM_001251202.1 XP_001251203.1
rat (Rattus norvegicus)	Fyn¹	--	FYN oncogene related to SRC, FGR, YES	92.86(n) 99.63(a)	25150 NM_012755.1 NP_036887.1
mouse (Mus musculus)	Fyn^{1, 5}	10 (25.00 cM)⁵	Fyn proto-oncogene^{1, 5}	88.83(n)¹ 94.19(a)¹	14360¹ NM_008054.1¹ NP_032080.1¹ AI448320⁵ AK156584⁵ (see all 27)

About this table Species with no ortholog for FYN

ENSEMBL Gene Tree for FYN

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FYN gene

SRC² FGR² YES1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1115 NCBI SNPs in FYN are shown (see all 1115 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 457)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs706895^1,2	A,C,F,H,O	112148052(+)	`CTCACT/CGTTGG`	3	--	int¹ ng3¹		18	MN NA EA EU WA	1882
	rs12910^1,2	A,C,F,H	112208468(-)	`GCGGAA/CATTTT`	1	--	ut5¹ ese³		16	EA NA EU WA	1468
	rs1409837^1,2	C,F,H,O	112302304(+)	`CACTTT/CGGCTT`	1	--	ng3¹		14	NA EA EU WA	1230
	rs6908503^1,2	A,C,F,H	112187453(+)	`CACTCG/AGTGCC`	2	--	int¹ ng3¹		3	EU EA	268
	rs1465061^1,2	A,C,F,H	112188309(+)	`CCTAAG/ATGCCT`	2	--	ng3¹ int¹		4	EU EA WA	420
	rs1740377^1,2	A,C,F,H	112149811(+)	`AATCAC/AATAAG`	3	--	ng3¹ int¹		4	EU EA WA	420
	rs6916861^1,2	A,C,F,H	112088950(+)	`TGAAAA/CAATTC`	3	--	ng5¹		12	EA NA EU WA	1050
	rs1535176^1,2	A,C,F,H	112302921(-)	`TCTACC/ACAACT`	1	--	ng3¹		11	EU EA WA NA	978
	rs1726113^1,2	A,C,F,H	112149826(+)	`ACATGC/ACATCA`	3	--	int¹ ng3¹		4	EU EA WA	412
	rs6914091^1,2	A,C,F,H	112188428(+)	`AGCTCT/CCCTGG`	2	--	int¹ ng3¹		7	NA EU EA WA	518

About this table

HapMap Linkage Disequilibrium images for FYN (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 137025

10/32 Novoseek disease relationships for FYN gene (see all 32 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
wiskott-aldrich syndrome	37.64	2	8810341 (1), 10532312 (1)
neurofibrillary tangles	23.26	2	15708437 (2)
leukemia t-cell	20.14	1	9045636 (1)
alzheimers disease	12.34	8	15098360 (2), 8388744 (1), 16237174 (1), 15082191 (1) (see all 6)
atrophy	4.98	2	8562954 (1)
lymphoma t-cell	4.10	1	11453661 (1)
shock	3.16	1	9155022 (1)
carcinoma squamous cell	3.15	1	12917446 (1)
lymphopenia	2.67	1	12614355 (1)
colon cancer	2.66	1	18805444 (1)

About this table

1 PharmGKB disease relationship for FYN gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872 12730115

About this table

Genetic Association Database: FYN
Human Genome Epidemiology Navigator: FYN (15 documents)
Tumor Gene Database: FYN

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/755 PubMed articles for FYN gene (see all 755 ):

Yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family. (PubMed id 3526330)^{2, 3, 4} Semba K.... Toyoshima K. (1986)
In vivo phosphorylation and membrane association of the fyn proto- oncogene product in IM-9 human lymphoblasts. (PubMed id 1699196)^{1, 3, 4} Peters D.J.... Laudano A.P. (1990)
Mutation and association analysis of the Fyn kinase gene with alcoholism and schizophrenia. (PubMed id 11121167)^{1, 3, 6} Ishiguro H....Arinami T. (2000)
[Analysis of the fyn kinase gene in Alzheimer's disease and schizophrenia] (PubMed id 15098360)^{1, 3, 6} Nakano Y....Nanko S. (2004)
No genetic association between Fyn kinase gene polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) and Japanese sporadic Alzheimer's disease. (PubMed id 15082191)^{1, 3, 6} Watanabe T....Arai H. (2004)
Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts. (PubMed id 14675807)^{1, 3, 6} Schumann G....Szegedi A. (2003)
Altered expression of tyrosine kinases of the Src and Syk families in human T-cell leukemia virus type 1-infected T-cell lines. (PubMed id 10196263)^{1, 3, 4} Weil R....Israel A. (1999)
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)^{3, 4} Wissing J.... Daub H. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance. (PubMed id 15557120)^{3, 4} Meriane M.... Lamarche-Vane N. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2534	HGNC: 4037	AceView: FYN	Ensembl:ENSG00000010810	euGenes: HUgn2534
ECgene: FYN	H-InvDB: FYN

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for FYN	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for FYN
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FYN:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FYN-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FYN		Antibodies for FYN
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FYN		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (FYN)
	Antibodies (FYN)
	Chimera RNAi (FYN)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for FYN

	Recombinant Proteins (Fyn)
	Antibodies (Fyn)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for FYN

	Drugs/Proteins for FYN
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for FYN

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
FYN Gene at Home site.
Version 2.41.1
server4.xennexinc.com

FYN Gene

protein-coding GIFtS: 75

Aliases &
Descriptions
for FYN

Summaries
for FYN

Genomic Location
for FYN

Proteins
for FYN

Protein Domains/
Families
for FYN

Gene Function
for FYN

Pathways & Interactions
for FYN

Drugs & Compounds
for FYN

Transcripts
for FYN

Expression
for FYN

Orthologs
for FYN

Paralogs
for FYN

SNPs/Variants
for FYN

Disorders & Mutations
for FYN

Medical News
for FYN

Publications
for FYN

Search for FYN

Genome Databases showing FYN

Other Databases showing FYN

Specialized Databases showing FYN

Licensable Technologies
for FYN

Services
for FYN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FYN Gene

protein-coding GIFtS: 75

Aliases & Descriptionsfor FYN

Summariesfor FYN

Genomic Locationfor FYN

Proteinsfor FYN

Protein Domains/Familiesfor FYN

Gene Functionfor FYN

Pathways & Interactionsfor FYN

Drugs & Compoundsfor FYN

Transcriptsfor FYN

Expression for FYN

Orthologsfor FYN

Paralogsfor FYN

SNPs/Variantsfor FYN

Disorders & Mutationsfor FYN

Medical Newsfor FYN

Publicationsfor FYN

Search for FYN

Genome Databases showing FYN

Other Databases showing FYN

Specialized Databases showing FYN

Licensable Technologiesfor FYN

Servicesfor FYN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FYN

Summaries
for FYN

Genomic Location
for FYN

Proteins
for FYN

Protein Domains/
Families
for FYN

Gene Function
for FYN

Pathways & Interactions
for FYN

Drugs & Compounds
for FYN

Transcripts
for FYN

Expression
for FYN

Orthologs
for FYN

Paralogs
for FYN

SNPs/Variants
for FYN

Disorders & Mutations
for FYN

Medical News
for FYN

Publications
for FYN

Licensable Technologies
for FYN

Services
for FYN