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Aliases for FYN Gene

Aliases for FYN Gene

  • FYN Proto-Oncogene, Src Family Tyrosine Kinase 2 3 5
  • FYN Oncogene Related To SRC, FGR, YES 2 3
  • Proto-Oncogene C-Fyn 3 4
  • Proto-Oncogene Syn 3 4
  • Src-Like Kinase 3 4
  • EC 2.7.10.2 4 63
  • P59-FYN 3 4
  • SLK 3 4
  • OKT3-Induced Calcium Influx Regulator 3
  • Tyrosine Kinase P59fyn(T) 3
  • Src/Yes-Related Novel 3
  • C-Syn Protooncogene 3
  • EC 2.7.10 63
  • SYN 3

External Ids for FYN Gene

Previous GeneCards Identifiers for FYN Gene

  • GC06M111817
  • GC06M112005
  • GC06M112028
  • GC06M112089
  • GC06M111981
  • GC06M109555

Summaries for FYN Gene

Entrez Gene Summary for FYN Gene

  • This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]

GeneCards Summary for FYN Gene

FYN (FYN Proto-Oncogene, Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with FYN include wiskott-aldrich syndrome. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ABL2.

UniProtKB/Swiss-Prot for FYN Gene

  • Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.

Tocris Summary for FYN Gene

  • Src kinases consist of eight non-receptor tyrosine kinases (Src, Fyn, Yes, Lck, Lyn, Hck, Fgr and Blk) that interact with the intracellular domains of growth factor/cytokine receptors, GPCRs and integrins. Members of the Src kinase family have a very similar domain structure.

Gene Wiki entry for FYN Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FYN Gene

Genomics for FYN Gene

Regulatory Elements for FYN Gene

Promoters for FYN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FYN on UCSC Golden Path with GeneCards custom track

Genomic Location for FYN Gene

Chromosome:
6
Start:
111,660,332 bp from pter
End:
111,873,452 bp from pter
Size:
213,121 bases
Orientation:
Minus strand

Genomic View for FYN Gene

Genes around FYN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FYN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FYN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FYN Gene

Proteins for FYN Gene

  • Protein details for FYN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06241-FYN_HUMAN
    Recommended name:
    Tyrosine-protein kinase Fyn
    Protein Accession:
    P06241
    Secondary Accessions:
    • B5BU57
    • E1P557
    • H0UI48
    • Q16248
    • Q5R3A6
    • Q5R3A7
    • Q8N5D7

    Protein attributes for FYN Gene

    Size:
    537 amino acids
    Molecular mass:
    60762 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts (via its SH3 domain) with PIK3R1 and PRMT8. Interacts with FYB, PAG1, and SH2D1A. Interacts with CD79A (tyrosine-phosphorylated form); the interaction increases FYN activity. Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (By similarity). Interacts with TOM1L1 (phosphorylated form). Interacts with KDR (tyrosine phosphorylated). Interacts (via SH3 domain) with KLHL2 (via N-terminus) (By similarity). Interacts with SH2D1A and SLAMF1. Interacts (via its SH3 domain) with HEV ORF3 protein. Interacts with ITCH; the interaction phosphorylates ITCH and negatively regulates its activity. Interacts with FASLG. Interacts with RUNX3. Interacts with KIT. Interacts with EPHA8; possible downstream effector of EPHA8 in regulation of cell adhesion. Interacts with PTK2/FAK1; this interaction leads to PTK2/FAK1 phosphorylation and activation. Interacts with CAV1; this interaction couples integrins to the Ras-ERK pathway. Interacts with UNC119.

    Three dimensional structures from OCA and Proteopedia for FYN Gene

    Alternative splice isoforms for FYN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FYN Gene

Proteomics data for FYN Gene at MOPED

Post-translational modifications for FYN Gene

  • Autophosphorylated at Tyr-420. Phosphorylation on the C-terminal tail at Tyr-531 by CSK maintains the enzyme in an inactive state (By similarity). PTPRC/CD45 dephosphorylates Tyr-531 leading to activation. Ultraviolet B (UVB) strongly increase phosphorylation at Thr-12 and kinase activity, and promotes translocation from the cytoplasm to the nucleus. Dephosphorylation at Tyr-420 by PTPN2 negatively regulates T-cell receptor signaling.
  • Palmitoylation at Cys-3 and Cys-6 regulates subcellular location.
  • Ubiquitination at Lys 405
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FYN (Fyn)

Domains & Families for FYN Gene

Gene Families for FYN Gene

Graphical View of Domain Structure for InterPro Entry

P06241

UniProtKB/Swiss-Prot:

FYN_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Domain:
  • Contains 1 protein kinase domain.
  • Contains 1 SH2 domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
genes like me logo Genes that share domains with FYN: view

Function for FYN Gene

Molecular function for FYN Gene

GENATLAS Biochemistry:
SRC/YES-related oncogene homolog,involved in T cell signaling regulation,STAR (signal transduction and activator of RNA) family
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site.
UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.

Enzyme Numbers (IUBMB) for FYN Gene

Gene Ontology (GO) - Molecular Function for FYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity IEA,TAS --
GO:0042608 T cell receptor binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FYN: view
genes like me logo Genes that share phenotypes with FYN: view

Animal Models for FYN Gene

MGI Knock Outs for FYN:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FYN Gene

Localization for FYN Gene

Subcellular locations from UniProtKB/Swiss-Prot for FYN Gene

Cytoplasm. Nucleus. Cell membrane. Note=Present and active in lipid rafts. Palmitoylation is crucial for proper trafficking.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FYN Gene COMPARTMENTS Subcellular localization image for FYN gene
Compartment Confidence
cytosol 5
endosome 5
nucleus 5
plasma membrane 5
cytoskeleton 4
mitochondrion 3
extracellular 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005768 endosome IDA 15611048
genes like me logo Genes that share ontologies with FYN: view

Pathways & Interactions for FYN Gene

SuperPathways for FYN Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 PI3K events in ERBB4 signaling
3 EPH-Ephrin signaling
4 Infectious disease
.48
5 Development Slit-Robo signaling
genes like me logo Genes that share pathways with FYN: view

SIGNOR curated interactions for FYN Gene

Gene Ontology (GO) - Biological Process for FYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0001764 neuron migration IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006468 protein phosphorylation IEA,NAS 7822789
genes like me logo Genes that share ontologies with FYN: view

Drugs & Compounds for FYN Gene

(37) Drugs for FYN Gene - From: Novoseek, HMDB, Tocris, DrugBank, ApexBio, DGIdb, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dasatinib Approved, Investigational Pharma Inhibition, inhibitor, Target, multitarget Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 268
Sprycel Approved June 2006 Pharma 0
Adenosine triphosphate Approved Nutra 0
Piceatannol Experimental Pharma p56lck/Syk inhibitor, Inhibits TNF-induced NF-kappaB activation 0
1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane Experimental Pharma Target 0

(31) Additional Compounds for FYN Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Lavendustin A
125697-92-9
MLR 1023
41964-07-2
PP 2
172889-27-9

(5) Tocris Compounds for FYN Gene

Compound Action Cas Number
Lavendustin A EGFR, p60c-src inhibitor 125697-92-9
MLR 1023 Selective allosteric activator of Lyn kinase 41964-07-2
Piceatannol Inhibits TNF-induced NF-kappaB activation 10083-24-6
PP 1 Potent, selective Src family kinase inhibitor 172889-26-8
PP 2 Potent, selective Src family kinase inhibitor 172889-27-9

(4) ApexBio Compounds for FYN Gene

Compound Action Cas Number
1-NM-PP1 Pp60c-src inhibitor 221244-14-0
KX2-391 Src inhibitor,highly selective 897016-82-9
NVP-BHG712 EphB4 inhibitor,potent and selective 940310-85-0
WH-4-023 Lck/Src inhibitor,potent and selective 837422-57-8
genes like me logo Genes that share compounds with FYN: view

Drug Products

Transcripts for FYN Gene

Unigene Clusters for FYN Gene

FYN oncogene related to SRC, FGR, YES:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FYN Gene

No ASD Table

Relevant External Links for FYN Gene

GeneLoc Exon Structure for
FYN
ECgene alternative splicing isoforms for
FYN

Expression for FYN Gene

mRNA expression in normal human tissues for FYN Gene

Protein differential expression in normal tissues from HIPED for FYN Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.6), Cervix (8.1), and Breast (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FYN Gene



SOURCE GeneReport for Unigene cluster for FYN Gene Hs.390567

mRNA Expression by UniProt/SwissProt for FYN Gene

P06241-FYN_HUMAN
Tissue specificity: Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T-lymphocytes.
genes like me logo Genes that share expression patterns with FYN: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for FYN Gene

Orthologs for FYN Gene

This gene was present in the common ancestor of animals.

Orthologs for FYN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FYN 35
  • 90.01 (n)
  • 94.57 (a)
FYN 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FYN 35
  • 89.39 (n)
  • 94.76 (a)
FYN 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fyn 35
  • 92.76 (n)
  • 98.69 (a)
Fyn 16
Fyn 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FYN 35
  • 95.07 (n)
  • 94.94 (a)
FYN 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fyn 35
  • 88.26 (n)
  • 94.57 (a)
oppossum
(Monodelphis domestica)
Mammalia FYN 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FYN 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves FYN 35
  • 85.27 (n)
  • 96.63 (a)
FYN 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FYN 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fyn 35
  • 81.34 (n)
  • 94.38 (a)
zebrafish
(Danio rerio)
Actinopterygii fynb 35
  • 74.34 (n)
  • 86.7 (a)
fyna 36
  • 92 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Src64B 37
  • 53 (a)
worm
(Caenorhabditis elegans)
Secernentea C25A8.5 37
  • 33 (a)
F23C8.7 37
  • 33 (a)
F57B9.8 37
  • 34 (a)
src-1 37
  • 48 (a)
src-1 35
  • 55.63 (n)
  • 54.51 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5221 35
Species with no ortholog for FYN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FYN Gene

ENSEMBL:
Gene Tree for FYN (if available)
TreeFam:
Gene Tree for FYN (if available)

Paralogs for FYN Gene

Paralogs for FYN Gene

genes like me logo Genes that share paralogs with FYN: view

Variants for FYN Gene

Sequence variations from dbSNP and Humsavar for FYN Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1801121 - 111,674,571(-) TCACA(A/T)TCAAG reference, missense
VAR_041704 A lung squamous cell carcinoma sample
VAR_041705 A metastatic melanoma sample
rs28763975 - 111,661,835(-) AAGGA(C/G/T)CCTGA reference, missense
rs12910 -- 111,780,572(-) GCGGA(A/C)ATTTT utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FYN Gene

Variant ID Type Subtype PubMed ID
nsv5444 CNV Insertion 18451855
esv2752088 CNV Gain 17911159
esv271837 CNV Insertion 20981092
nsv5445 CNV Loss 18451855
esv2662755 CNV Deletion 23128226

Variation tolerance for FYN Gene

Residual Variation Intolerance Score: 9.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FYN Gene

HapMap Linkage Disequilibrium report
FYN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FYN Gene

Disorders for FYN Gene

MalaCards: The human disease database

(1) MalaCards diseases for FYN Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
wiskott-aldrich syndrome
  • wiskott syndrome
- elite association - COSMIC cancer census association via MalaCards
Search FYN in MalaCards View complete list of genes associated with diseases

Relevant External Links for FYN

Genetic Association Database (GAD)
FYN
Human Genome Epidemiology (HuGE) Navigator
FYN
Tumor Gene Database (TGDB):
FYN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FYN
genes like me logo Genes that share disorders with FYN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FYN Gene

Publications for FYN Gene

  1. Yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family. (PMID: 3526330) Semba K. … Toyoshima K. (Proc. Natl. Acad. Sci. U.S.A. 1986) 2 3 4 67
  2. Fyn: a novel molecular target in cancer. (PMID: 20151426) Saito Y.D. … Posadas E.M. (Cancer 2010) 3 23
  3. Roles of Fyn in pancreatic cancer metastasis. (PMID: 19968749) Chen Z.Y. … Li X.W. (J. Gastroenterol. Hepatol. 2010) 3 23
  4. Dasatinib. (PMID: 20072833) Lindauer M. … Hochhaus A. (Recent Results Cancer Res. 2010) 25 26
  5. Oxidative stress promotes transcriptional up-regulation of Fyn in BCR-ABL1-expressing cells. (PMID: 19131339) Gao Y. … Chandra J. (J. Biol. Chem. 2009) 3 23

Products for FYN Gene

  • Addgene plasmids for FYN

Sources for FYN Gene

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