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Aliases for FYN Gene

Aliases for FYN Gene

  • FYN Proto-Oncogene, Src Family Tyrosine Kinase 2 3
  • FYN Oncogene Related To SRC, FGR, YES 2 3
  • Proto-Oncogene C-Fyn 3 4
  • Proto-Oncogene Syn 3 4
  • Src-Like Kinase 3 4
  • EC 2.7.10.2 4 63
  • P59-FYN 3 4
  • SLK 3 4
  • OKT3-Induced Calcium Influx Regulator 3
  • Tyrosine-Protein Kinase Fyn 3
  • Tyrosine Kinase P59fyn(T) 3
  • Src/Yes-Related Novel 3
  • C-Syn Protooncogene 3
  • EC 2.7.10 63
  • SYN 3

External Ids for FYN Gene

Previous GeneCards Identifiers for FYN Gene

  • GC06M111817
  • GC06M112005
  • GC06M112028
  • GC06M112089
  • GC06M111981
  • GC06M109555

Summaries for FYN Gene

Entrez Gene Summary for FYN Gene

  • This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]

GeneCards Summary for FYN Gene

FYN (FYN Proto-Oncogene, Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with FYN include estrogen-receptor negative breast cancer. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include identical protein binding and ion channel binding. An important paralog of this gene is ABL2.

UniProtKB/Swiss-Prot for FYN Gene

  • Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.

Tocris Summary for FYN Gene

  • Src kinases consist of eight non-receptor tyrosine kinases (Src, Fyn, Yes, Lck, Lyn, Hck, Fgr and Blk) that interact with the intracellular domains of growth factor/cytokine receptors, GPCRs and integrins. Members of the Src kinase family have a very similar domain structure with a high degree of homology in the SH1 (catalytic), linker, SH2 (p-Tyr binding), SH3 (protein-protein interaction) and SH4 (membrane association) domains. c-Src, Fyn and Yes are ubiquitously expressed, although high levels of c-Src are found in platelets, neural tissue and osteoclasts. For c-Src, autophosphorylation of Tyr418 and dephosphorylation of Tyr530 is required to switch the kinase from the inactive closed formation to the active open formation. c-Src can be inactivated by two kinases, c-Src kinase (CSK) and CSK homologous kinase (CHK), both of which phosphorylate Tyr530 of c-Src. The activity of the Src kinase family can also be regulated by phosphatases (e.g. SHP1), binding to adaptor proteins (e.g. Cbp) and proteasomal degradation. Src kinases are key upstream mediators of both the PI 3-K and MAPK signaling pathways, and have been shown to have important roles in cell proliferation, migration and survival.

Gene Wiki entry for FYN Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FYN Gene

Genomics for FYN Gene

Regulatory Elements for FYN Gene

Genomic Location for FYN Gene

Start:
111,660,332 bp from pter
End:
111,873,452 bp from pter
Size:
213,121 bases
Orientation:
Minus strand

Genomic View for FYN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FYN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FYN Gene

Proteins for FYN Gene

  • Protein details for FYN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06241-FYN_HUMAN
    Recommended name:
    Tyrosine-protein kinase Fyn
    Protein Accession:
    P06241
    Secondary Accessions:
    • B5BU57
    • E1P557
    • H0UI48
    • Q16248
    • Q5R3A6
    • Q5R3A7
    • Q8N5D7

    Protein attributes for FYN Gene

    Size:
    537 amino acids
    Molecular mass:
    60762 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts (via its SH3 domain) with PIK3R1 and PRMT8. Interacts with FYB, PAG1, and SH2D1A. Interacts with CD79A (tyrosine-phosphorylated form); the interaction increases FYN activity. Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (By similarity). Interacts with TOM1L1 (phosphorylated form). Interacts with KDR (tyrosine phosphorylated). Interacts (via SH3 domain) with KLHL2 (via N-terminus) (By similarity). Interacts with SH2D1A and SLAMF1. Interacts (via its SH3 domain) with HEV ORF3 protein. Interacts with ITCH; the interaction phosphorylates ITCH and negatively regulates its activity. Interacts with FASLG. Interacts with RUNX3. Interacts with KIT. Interacts with EPHA8; possible downstream effector of EPHA8 in regulation of cell adhesion. Interacts with PTK2/FAK1; this interaction leads to PTK2/FAK1 phosphorylation and activation. Interacts with CAV1; this interaction couples integrins to the Ras-ERK pathway. Interacts with UNC119.

    Three dimensional structures from OCA and Proteopedia for FYN Gene

    Alternative splice isoforms for FYN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FYN Gene

Proteomics data for FYN Gene at MOPED

Post-translational modifications for FYN Gene

  • Autophosphorylated at Tyr-420. Phosphorylation on the C-terminal tail at Tyr-531 by CSK maintains the enzyme in an inactive state (By similarity). PTPRC/CD45 dephosphorylates Tyr-531 leading to activation. Ultraviolet B (UVB) strongly increase phosphorylation at Thr-12 and kinase activity, and promotes translocation from the cytoplasm to the nucleus. Dephosphorylation at Tyr-420 by PTPN2 negatively regulates T-cell receptor signaling.
  • Palmitoylation at Cys-3 and Cys-6 regulates subcellular location.
  • Ubiquitination at Lys182, Lys405, and Lys431
  • Modification sites at PhosphoSitePlus

Domains for FYN Gene

Gene Families for FYN Gene

HGNC:
  • SH2D :SH2 domain containing
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P06241

UniProtKB/Swiss-Prot:

FYN_HUMAN :
  • P06241
Domain:
  • Contains 1 protein kinase domain.
  • Contains 1 SH2 domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
genes like me logo Genes that share domains with FYN: view

Function for FYN Gene

Molecular function for FYN Gene

GENATLAS Biochemistry: SRC/YES-related oncogene homolog,involved in T cell signaling regulation,STAR (signal transduction and activator of RNA) family
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site
UniProtKB/Swiss-Prot Function: Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.

Enzyme Numbers (IUBMB) for FYN Gene

Gene Ontology (GO) - Molecular Function for FYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IEA --
GO:0001948 glycoprotein binding IPI 16831868
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004715 non-membrane spanning protein tyrosine kinase activity NAS 7822789
genes like me logo Genes that share ontologies with FYN: view
genes like me logo Genes that share phenotypes with FYN: view

Animal Models for FYN Gene

MGI Knock Outs for FYN:

miRNA for FYN Gene

miRTarBase miRNAs that target FYN

No data available for Transcription Factor Targeting and HOMER Transcription for FYN Gene

Localization for FYN Gene

Subcellular locations from UniProtKB/Swiss-Prot for FYN Gene

Cytoplasm. Nucleus. Cell membrane. Note=Present and active in lipid rafts. Palmitoylation is crucial for proper trafficking.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FYN Gene COMPARTMENTS Subcellular localization image for FYN gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 4
endosome 4
cytoskeleton 2
extracellular 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for FYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IEA --
GO:0005768 endosome IDA 15611048
GO:0005829 cytosol TAS --
GO:0005884 actin filament IEA --
genes like me logo Genes that share ontologies with FYN: view

Pathways for FYN Gene

SuperPathways for FYN Gene

genes like me logo Genes that share pathways with FYN: view

Gene Ontology (GO) - Biological Process for FYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006468 protein phosphorylation NAS 7822789
GO:0006816 calcium ion transport NAS 7822789
GO:0007166 cell surface receptor signaling pathway --
genes like me logo Genes that share ontologies with FYN: view

Compounds for FYN Gene

(5) Tocris Compounds for FYN Gene

Compound Action Cas Number
1-Naphthyl PP1 Src family kinase inhibitor; also inhibits c-Abl [221243-82-9]
KB SRC 4 Potent and selective c-Src inhibitor [1380088-03-8]
PP 2 Potent, selective Src family kinase inhibitor [172889-27-9]
PP 3 Negative control for PP 2 (Cat. No. 1407) [5334-30-5]
Src I1 Dual site Src kinase inhibitor [179248-59-0]

(4) HMDB Compounds for FYN Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2
Manganese
  • manganese
7439-96-5

(2) Drugbank Compounds for FYN Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane
target
Dasatinib
302962-49-8 target multitarget

(53) Novoseek inferred chemical compound relationships for FYN Gene

Compound -log(P) Hits PubMed IDs
tyrosine 89.5 203
phosphotyrosine 73.1 10
herbimycin a 67.6 3
phosphatidylinositol 65.7 37
4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine 54.1 1
genes like me logo Genes that share compounds with FYN: view

Transcripts for FYN Gene

Unigene Clusters for FYN Gene

FYN oncogene related to SRC, FGR, YES:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FYN Gene

No ASD Table

Relevant External Links for FYN Gene

GeneLoc Exon Structure for
FYN
ECgene alternative splicing isoforms for
FYN

Expression for FYN Gene

mRNA expression in normal human tissues for FYN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FYN Gene

SOURCE GeneReport for Unigene cluster for FYN Gene Hs.390567

mRNA Expression by UniProt/SwissProt for FYN Gene

P06241-FYN_HUMAN
Tissue specificity: Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T-lymphocytes.
genes like me logo Genes that share expressions with FYN: view

No data available for mRNA differential expression in normal tissues for FYN Gene

Orthologs for FYN Gene

This gene was present in the common ancestor of animals.

Orthologs for FYN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FYN 35
  • 95.07 (n)
  • 94.94 (a)
FYN 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FYN 35
  • 90.01 (n)
  • 94.57 (a)
FYN 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FYN 35
  • 89.39 (n)
  • 94.76 (a)
FYN 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fyn 35
  • 92.76 (n)
  • 98.69 (a)
Fyn 16
Fyn 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FYN 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FYN 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fyn 35
  • 88.26 (n)
  • 94.57 (a)
chicken
(Gallus gallus)
Aves FYN 35
  • 85.27 (n)
  • 96.63 (a)
FYN 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FYN 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fyn 35
  • 81.34 (n)
  • 94.38 (a)
zebrafish
(Danio rerio)
Actinopterygii fyna 36
  • 92 (a)
OneToOne
fynb 35
  • 74.34 (n)
  • 86.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta Src64B 37
  • 53 (a)
worm
(Caenorhabditis elegans)
Secernentea src-1 35
  • 55.63 (n)
  • 54.51 (a)
F23C8.7 37
  • 33 (a)
C25A8.5 37
  • 33 (a)
src-1 37
  • 48 (a)
F57B9.8 37
  • 34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5221 35
Species with no ortholog for FYN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FYN Gene

ENSEMBL:
Gene Tree for FYN (if available)
TreeFam:
Gene Tree for FYN (if available)

Paralogs for FYN Gene

Paralogs for FYN Gene

genes like me logo Genes that share paralogs with FYN: view

Variants for FYN Gene

Sequence variations from dbSNP and Humsavar for FYN Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs697640 -- 111,718,519(+) CACTC(A/G)TGAAT intron-variant
rs697641 -- 111,723,315(+) CTTGC(A/G)TGGCC intron-variant
rs697642 -- 111,731,902(+) CACTA(A/G)AGGTC intron-variant
rs706861 -- 111,681,758(-) CAAGC(A/G)CTCAG intron-variant
rs706862 -- 111,682,545(-) TCTGC(A/G)GTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FYN Gene

Variant ID Type Subtype PubMed ID
nsv5444 CNV Insertion 18451855
esv2752088 CNV Gain 17911159
esv271837 CNV Insertion 20981092
nsv5445 CNV Loss 18451855
esv2662755 CNV Deletion 23128226

Relevant External Links for FYN Gene

HapMap Linkage Disequilibrium report
FYN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FYN Gene

Disorders for FYN Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for FYN Gene including...

Search for FYN Gene in MalaCards »

(2) University of Copenhagen DISEASES for FYN Gene

(33) Novoseek inferred disease relationships for FYN Gene

Disease -log(P) Hits PubMed IDs
wiskott-aldrich syndrome 49 3
neurofibrillary tangles 30.4 2
leukemia t-cell 18.8 1
alzheimers disease 13.7 7
atrophy 4.76 1

Relevant External Links for FYN

Genetic Association Database (GAD)
FYN
Human Genome Epidemiology (HuGE) Navigator
FYN
Tumor Gene Database (TGDB):
FYN
genes like me logo Genes that share disorders with FYN: view

No data available for UniProtKB/Swiss-Prot for FYN Gene

Publications for FYN Gene

  1. In vivo phosphorylation and membrane association of the fyn proto- oncogene product in IM-9 human lymphoblasts. (PMID: 1699196) Peters D.J. … Laudano A.P. (Oncogene 1990) 3 4 23
  2. Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity. (PMID: 10498895) Choi S. … Park S. (Oncogene 1999) 3 4 23
  3. Mutation and association analysis of the Fyn kinase gene with alcoholism and schizophrenia. (PMID: 11121167) Ishiguro H. … Arinami T. (Am. J. Med. Genet. 2000) 3 23 48
  4. Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125. (PMID: 11162638) Nakamura T. … Nakamura S. (Biochem. Biophys. Res. Commun. 2001) 3 4 23
  5. p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn. (PMID: 12788081) Taniguchi S. … Yamamoto T. (Biochem. Biophys. Res. Commun. 2003) 3 4 23

Products for FYN Gene

  • Addgene plasmids for FYN

Sources for FYN Gene

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