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Aliases for FZR1 Gene

Aliases for FZR1 Gene

  • Fizzy/Cell Division Cycle 20 Related 1 (Drosophila) 2 3
  • FZR 3 4 6
  • CDC20-Like Protein 1 3 4
  • Cdh1/Hct1 Homolog 3 4
  • HCDH1 3 4
  • HCDH 3 6
  • CDH1 3 4
  • Fizzy-Related Protein Homolog 3
  • CDC20-Like 1b 3
  • KIAA1242 4
  • CDC20C 3
  • FZR2 3
  • FYR 4

External Ids for FZR1 Gene

Summaries for FZR1 Gene

GeneCards Summary for FZR1 Gene

FZR1 (Fizzy/Cell Division Cycle 20 Related 1 (Drosophila)) is a Protein Coding gene. Among its related pathways are Glioma and Ras signaling pathway. An important paralog of this gene is CDC20B.

UniProtKB/Swiss-Prot for FZR1 Gene

  • Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Gene Wiki entry for FZR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FZR1 Gene

Genomics for FZR1 Gene

Genomic Location for FZR1 Gene

Start:
3,506,263 bp from pter
End:
3,538,330 bp from pter
Size:
32,068 bases
Orientation:
Plus strand

Genomic View for FZR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FZR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FZR1 Gene

Regulatory Elements for FZR1 Gene

Proteins for FZR1 Gene

  • Protein details for FZR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UM11-FZR_HUMAN
    Recommended name:
    Fizzy-related protein homolog
    Protein Accession:
    Q9UM11
    Secondary Accessions:
    • O75869
    • Q86U66
    • Q96NW8
    • Q9UI96
    • Q9ULH8
    • Q9UM10
    • Q9UNQ1
    • Q9Y2T8

    Protein attributes for FZR1 Gene

    Size:
    496 amino acids
    Molecular mass:
    55179 Da
    Quaternary structure:
    • The unphosphorylated form interacts with APC/C during mitosis. Interacts with NINL. Interacts (in complex with the anaphase promoting complex APC) with MAD2L2; inhibits FZR1-mediated APC/C activation. Interacts with SIRT2 and USP37. Interacts (via WD repeats) with MAK.
    SequenceCaution:
    • Sequence=AAD26623.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305}; Sequence=AAD26624.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BAA86556.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FZR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FZR1 Gene

Proteomics data for FZR1 Gene at MOPED

Post-translational modifications for FZR1 Gene

  • Acetylated. Deacetylated by SIRT2 at Lys-69 and Lys-159; deacetylation enhances the interaction of FZR1 with CDC27, leading to activation of anaphase promoting complex/cyclosome (APC/C).
  • Phosphorylated during mitosis, probably by maturation promoting factor (MPF), leading to its dissociation of the APC/C. Following DNA damage, it is dephosphorylated by CDC14B in G2 phase, leading to its reassociation with the APC/C, and allowing an efficient G2 DNA damage checkpoint. Phosphorylated by MAK.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys135 and Lys263

Other Protein References for FZR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FZR1 Gene

Domains for FZR1 Gene

Gene Families for FZR1 Gene

HGNC:
  • WDR :WD repeat domain containing

UniProtKB/Swiss-Prot:

FZR_HUMAN
Family:
  • Belongs to the WD repeat CDC20/Fizzy family.:
    • Q9UM11
Similarity:
  • Contains 7 WD repeats.:
    • Q9UM11
genes like me logo Genes that share domains with FZR1: view

Function for FZR1 Gene

Molecular function for FZR1 Gene

UniProtKB/Swiss-Prot Function: Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Gene Ontology (GO) - Molecular Function for FZR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11459826
genes like me logo Genes that share ontologies with FZR1: view
genes like me logo Genes that share phenotypes with FZR1: view

Animal Models for FZR1 Gene

MGI Knock Outs for FZR1:

miRNA for FZR1 Gene

miRTarBase miRNAs that target FZR1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FZR1 Gene

Localization for FZR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FZR1 Gene

Isoform 2: Nucleus.
Isoform 3: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FZR1 Gene COMPARTMENTS Subcellular localization image for FZR1 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FZR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005680 colocalizes_with anaphase-promoting complex IDA 11459825
GO:0005829 cytosol TAS --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with FZR1: view

Pathways for FZR1 Gene

SuperPathways for FZR1 Gene

genes like me logo Genes that share pathways with FZR1: view

UniProtKB/Swiss-Prot Q9UM11-FZR_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for FZR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006281 DNA repair IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS --
genes like me logo Genes that share ontologies with FZR1: view

Compounds for FZR1 Gene

(1) Novoseek inferred chemical compound relationships for FZR1 Gene

Compound -log(P) Hits PubMed IDs
serine 4.24 1
genes like me logo Genes that share compounds with FZR1: view

Transcripts for FZR1 Gene

Unigene Clusters for FZR1 Gene

Fizzy/cell division cycle 20 related 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FZR1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b · 14c
SP1: - - -
SP2: - -
SP3: - - - - -
SP4:
SP5:
SP6: -

Relevant External Links for FZR1 Gene

GeneLoc Exon Structure for
FZR1
ECgene alternative splicing isoforms for
FZR1

Expression for FZR1 Gene

mRNA expression in normal human tissues for FZR1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FZR1 Gene

SOURCE GeneReport for Unigene cluster for FZR1 Gene Hs.413133

mRNA Expression by UniProt/SwissProt for FZR1 Gene

Q9UM11-FZR_HUMAN
Tissue specificity: Isoform 2 is expressed at high levels in heart, liver, spleen and some cancer cell lines whereas isoform 3 is expressed only at low levels in these tissues.
genes like me logo Genes that share expressions with FZR1: view

Orthologs for FZR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FZR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FZR1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FZR1 36
  • 90.53 (n)
  • 98.99 (a)
FZR1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FZR1 36
  • 91.28 (n)
  • 98.78 (a)
FZR1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fzr1 36
  • 88.03 (n)
  • 98.38 (a)
Fzr1 16
Fzr1 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FZR1 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FZR1 37
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fzr1 36
  • 87.63 (n)
  • 97.97 (a)
chicken
(Gallus gallus)
Aves CDH1-A 36
  • 83.37 (n)
  • 97.57 (a)
CDH1-A 37
  • 98 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia fzr1-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fzr1 36
  • 77.89 (n)
  • 96.35 (a)
Str.20252 36
zebrafish
(Danio rerio)
Actinopterygii fzr1 36
  • 75.81 (n)
  • 91.67 (a)
fzr1 37
  • 92 (a)
OneToOne
zgc55450 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002114 36
  • 70.21 (n)
  • 73.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta fzr2 37
  • 49 (a)
OneToMany
rap 36
  • 68.85 (n)
  • 75.79 (a)
rap 37
  • 71 (a)
OneToMany
fzr2 38
  • 49 (a)
rap 38
  • 68 (a)
worm
(Caenorhabditis elegans)
Secernentea fzr-1 36
  • 57.43 (n)
  • 66.3 (a)
fzr-1 37
  • 38 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL007C 36
  • 52.3 (n)
  • 50.15 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDH1 36
  • 48.84 (n)
  • 45.39 (a)
CDH1 37
  • 34 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A08822g 36
  • 48.29 (n)
  • 49.56 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3232 36
soybean
(Glycine max)
eudicotyledons Gma.12561 36
thale cress
(Arabidopsis thaliana)
eudicotyledons FZR3 36
  • 55.45 (n)
  • 59.51 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.6041 36
corn
(Zea mays)
Liliopsida Zm.14057 36
rice
(Oryza sativa)
Liliopsida Os01g0972900 36
  • 57.03 (n)
  • 57.82 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.27562 36
bread mold
(Neurospora crassa)
Ascomycetes NCU01269 36
  • 58.06 (n)
  • 60.23 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes srw1 36
  • 50.16 (n)
  • 51.87 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4550 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 66 (a)
OneToOne
Species with no ortholog for FZR1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for FZR1 Gene

ENSEMBL:
Gene Tree for FZR1 (if available)
TreeFam:
Gene Tree for FZR1 (if available)

Paralogs for FZR1 Gene

Paralogs for FZR1 Gene

Selected SIMAP similar genes for FZR1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FZR1: view

Variants for FZR1 Gene

Sequence variations from dbSNP and Humsavar for FZR1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs10155 -- 3,534,844(-) CTGCC(C/T)GGCAG utr-variant-3-prime
rs740681 -- 3,533,276(-) GGGGG(C/T)GCTGC intron-variant
rs740682 -- 3,533,488(-) ATCCT(C/T)CCTAA intron-variant
rs740683 -- 3,533,805(+) TTGCC(A/C)AGATT intron-variant
rs740685 -- 3,534,657(-) TGCCC(C/T)GACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FZR1 Gene

Variant ID Type Subtype PubMed ID
nsv910722 CNV Loss 21882294
nsv910723 CNV Loss 21882294
dgv3651n71 CNV Loss 21882294
nsv470114 CNV Loss 18288195
dgv3652n71 CNV Loss 21882294
dgv3653n71 CNV Loss 21882294
dgv3654n71 CNV Loss 21882294
dgv3655n71 CNV Loss 21882294
dgv3656n71 CNV Loss 21882294
nsv910745 CNV Loss 21882294
nsv910746 CNV Loss 21882294
esv2717946 CNV Deletion 23290073
esv26869 CNV Loss 19812545
esv2675938 CNV Deletion 23128226
esv2663038 CNV Deletion 23128226
esv2717947 CNV Deletion 23290073
dgv613e199 CNV Deletion 23128226
esv2717948 CNV Deletion 23290073
esv2669455 CNV Deletion 23128226
dgv3657n71 CNV Loss 21882294

Relevant External Links for FZR1 Gene

HapMap Linkage Disequilibrium report
FZR1

Disorders for FZR1 Gene

Relevant External Links for FZR1

Genetic Association Database (GAD)
FZR1
Human Genome Epidemiology (HuGE) Navigator
FZR1
genes like me logo Genes that share disorders with FZR1: view

No data available for UniProtKB/Swiss-Prot for FZR1 Gene

Publications for FZR1 Gene

  1. Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1. (PMID: 9734353) Fang G. … Kirschner M.W. (Mol. Cell 1998) 2 3 4 23
  2. Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family. (PMID: 9811605) Kramer E.R. … Peters J.-M. (Curr. Biol. 1998) 3 4 23
  3. MAD2B is an inhibitor of the anaphase-promoting complex. (PMID: 11459826) Chen J. … Fang G. (Genes Dev. 2001) 3 4 23
  4. Cell cycle-dependent expression of centrosomal ninein-like protein in human cells is regulated by the anaphase-promoting complex. (PMID: 17403670) Wang Y. … Zhan Q. (J. Biol. Chem. 2007) 3 4 23
  5. The anaphase-promoting complex coordinates initiation of lens differentiation. (PMID: 17215516) Wu G. … Wan Y. (Mol. Biol. Cell 2007) 3 23

Products for FZR1 Gene

  • Addgene plasmids for FZR1

Sources for FZR1 Gene

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