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Aliases for FZR1 Gene

Aliases for FZR1 Gene

  • Fizzy/Cell Division Cycle 20 Related 1 2 3
  • CDC20-Like Protein 1 3 4
  • Cdh1/Hct1 Homolog 3 4
  • CDC20 Homolog 1 2 3
  • HCDH1 3 4
  • CDH1 3 4
  • FZR 3 4
  • Fizzy/Cell Division Cycle 20 Related 1 (Drosophila) 2
  • CDC20-Like 1b 3
  • KIAA1242 4
  • CDC20C 3
  • FZR2 3
  • HCDH 3
  • FYR 4

External Ids for FZR1 Gene

Previous GeneCards Identifiers for FZR1 Gene

  • GC19P003598
  • GC19P003446
  • GC19P003457
  • GC19P003473
  • GC19P003272

Summaries for FZR1 Gene

GeneCards Summary for FZR1 Gene

FZR1 (Fizzy/Cell Division Cycle 20 Related 1) is a Protein Coding gene. Among its related pathways are Immune System and Signaling by GPCR. An important paralog of this gene is CDC20B.

UniProtKB/Swiss-Prot for FZR1 Gene

  • Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Gene Wiki entry for FZR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FZR1 Gene

Genomics for FZR1 Gene

Regulatory Elements for FZR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FZR1 Gene

Chromosome:
19
Start:
3,506,065 bp from pter
End:
3,538,539 bp from pter
Size:
32,475 bases
Orientation:
Plus strand

Genomic View for FZR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for FZR1 Gene

Proteins for FZR1 Gene

  • Protein details for FZR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UM11-FZR_HUMAN
    Recommended name:
    Fizzy-related protein homolog
    Protein Accession:
    Q9UM11
    Secondary Accessions:
    • O75869
    • Q86U66
    • Q96NW8
    • Q9UI96
    • Q9ULH8
    • Q9UM10
    • Q9UNQ1
    • Q9Y2T8

    Protein attributes for FZR1 Gene

    Size:
    496 amino acids
    Molecular mass:
    55179 Da
    Quaternary structure:
    • The unphosphorylated form interacts with APC/C during mitosis. Interacts with NINL. Interacts (in complex with the anaphase promoting complex APC) with MAD2L2; inhibits FZR1-mediated APC/C activation. Interacts with SIRT2 and USP37. Interacts (via WD repeats) with MAK.
    SequenceCaution:
    • Sequence=AAD26623.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305}; Sequence=AAD26624.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BAA86556.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FZR1 Gene

    Alternative splice isoforms for FZR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FZR1 Gene

Proteomics data for FZR1 Gene at MOPED

Post-translational modifications for FZR1 Gene

  • Acetylated. Deacetylated by SIRT2 at Lys-69 and Lys-159; deacetylation enhances the interaction of FZR1 with CDC27, leading to activation of anaphase promoting complex/cyclosome (APC/C).
  • Phosphorylated during mitosis, probably by maturation promoting factor (MPF), leading to its dissociation of the APC/C. Following DNA damage, it is dephosphorylated by CDC14B in G2 phase, leading to its reassociation with the APC/C, and allowing an efficient G2 DNA damage checkpoint. Phosphorylated by MAK.
  • Ubiquitination at Lys 135 and Lys 263
  • Modification sites at PhosphoSitePlus

Other Protein References for FZR1 Gene

Antibody Products

No data available for DME Specific Peptides for FZR1 Gene

Domains & Families for FZR1 Gene

Gene Families for FZR1 Gene

Suggested Antigen Peptide Sequences for FZR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UM11

UniProtKB/Swiss-Prot:

FZR_HUMAN :
  • Belongs to the WD repeat CDC20/Fizzy family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat CDC20/Fizzy family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with FZR1: view

Function for FZR1 Gene

Molecular function for FZR1 Gene

UniProtKB/Swiss-Prot Function:
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Gene Ontology (GO) - Molecular Function for FZR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11459826
genes like me logo Genes that share ontologies with FZR1: view
genes like me logo Genes that share phenotypes with FZR1: view

Animal Models for FZR1 Gene

MGI Knock Outs for FZR1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FZR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FZR1 Gene

Localization for FZR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FZR1 Gene

Isoform 2: Nucleus.
Isoform 3: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FZR1 Gene COMPARTMENTS Subcellular localization image for FZR1 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for FZR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005680 colocalizes_with anaphase-promoting complex IDA 11459825
GO:0005829 cytosol TAS --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with FZR1: view

Pathways & Interactions for FZR1 Gene

genes like me logo Genes that share pathways with FZR1: view

UniProtKB/Swiss-Prot Q9UM11-FZR_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for FZR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006281 DNA repair IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS --
genes like me logo Genes that share ontologies with FZR1: view

No data available for SIGNOR curated interactions for FZR1 Gene

Drugs & Compounds for FZR1 Gene

(1) Drugs for FZR1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
serine Nutra 420
genes like me logo Genes that share compounds with FZR1: view

Transcripts for FZR1 Gene

Unigene Clusters for FZR1 Gene

Fizzy/cell division cycle 20 related 1 (Drosophila):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FZR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FZR1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b · 14c
SP1: - - -
SP2: - -
SP3: - - - - -
SP4:
SP5:
SP6: -

Relevant External Links for FZR1 Gene

GeneLoc Exon Structure for
FZR1
ECgene alternative splicing isoforms for
FZR1

Expression for FZR1 Gene

mRNA expression in normal human tissues for FZR1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FZR1 Gene



SOURCE GeneReport for Unigene cluster for FZR1 Gene Hs.413133

mRNA Expression by UniProt/SwissProt for FZR1 Gene

Q9UM11-FZR_HUMAN
Tissue specificity: Isoform 2 is expressed at high levels in heart, liver, spleen and some cancer cell lines whereas isoform 3 is expressed only at low levels in these tissues.
genes like me logo Genes that share expression patterns with FZR1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for FZR1 Gene

Orthologs for FZR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FZR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FZR1 35
  • 90.53 (n)
  • 98.99 (a)
FZR1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FZR1 35
  • 91.28 (n)
  • 98.78 (a)
FZR1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fzr1 35
  • 88.03 (n)
  • 98.38 (a)
Fzr1 16
Fzr1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fzr1 35
  • 87.63 (n)
  • 97.97 (a)
oppossum
(Monodelphis domestica)
Mammalia FZR1 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FZR1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FZR1 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDH1-A 35
  • 83.37 (n)
  • 97.57 (a)
CDH1-A 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fzr1 35
  • 77.89 (n)
  • 96.35 (a)
Str.20252 35
African clawed frog
(Xenopus laevis)
Amphibia fzr1-prov 35
zebrafish
(Danio rerio)
Actinopterygii fzr1 35
  • 75.81 (n)
  • 91.67 (a)
zgc55450 35
fzr1 36
  • 92 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta fzr2 37
  • 49 (a)
rap 37
  • 68 (a)
rap 35
  • 68.85 (n)
  • 75.79 (a)
fzr2 36
  • 49 (a)
OneToMany
rap 36
  • 71 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002114 35
  • 70.21 (n)
  • 73.98 (a)
worm
(Caenorhabditis elegans)
Secernentea fzr-1 35
  • 57.43 (n)
  • 66.3 (a)
fzr-1 36
  • 38 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL007C 35
  • 52.3 (n)
  • 50.15 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A08822g 35
  • 48.29 (n)
  • 49.56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDH1 35
  • 48.84 (n)
  • 45.39 (a)
CDH1 36
  • 34 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons FZR3 35
  • 55.45 (n)
  • 59.51 (a)
soybean
(Glycine max)
eudicotyledons Gma.12561 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3232 35
barley
(Hordeum vulgare)
Liliopsida Hv.6041 35
rice
(Oryza sativa)
Liliopsida Os01g0972900 35
  • 57.03 (n)
  • 57.82 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.27562 35
corn
(Zea mays)
Liliopsida Zm.14057 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4550 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01269 35
  • 58.06 (n)
  • 60.23 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes srw1 35
  • 50.16 (n)
  • 51.87 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
OneToOne
Species with no ortholog for FZR1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for FZR1 Gene

ENSEMBL:
Gene Tree for FZR1 (if available)
TreeFam:
Gene Tree for FZR1 (if available)

Paralogs for FZR1 Gene

Paralogs for FZR1 Gene

(3) SIMAP similar genes for FZR1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FZR1: view

Variants for FZR1 Gene

Sequence variations from dbSNP and Humsavar for FZR1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs10155 -- 3,534,844(-) CTGCC(C/T)GGCAG utr-variant-3-prime, nc-transcript-variant
rs740681 -- 3,533,276(-) GGGGG(C/T)GCTGC intron-variant
rs740682 -- 3,533,488(-) ATCCT(C/T)CCTAA intron-variant
rs740683 -- 3,533,805(+) TTGCC(A/C)AGATT intron-variant
rs740685 -- 3,534,657(-) TGCCC(C/T)GACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FZR1 Gene

Variant ID Type Subtype PubMed ID
nsv910722 CNV Loss 21882294
nsv910723 CNV Loss 21882294
dgv3651n71 CNV Loss 21882294
nsv470114 CNV Loss 18288195
dgv3652n71 CNV Loss 21882294
dgv3653n71 CNV Loss 21882294
dgv3654n71 CNV Loss 21882294
dgv3655n71 CNV Loss 21882294
dgv3656n71 CNV Loss 21882294
nsv910745 CNV Loss 21882294
nsv910746 CNV Loss 21882294
esv2717946 CNV Deletion 23290073
esv26869 CNV Loss 19812545
esv2675938 CNV Deletion 23128226
esv2663038 CNV Deletion 23128226
esv2717947 CNV Deletion 23290073
dgv613e199 CNV Deletion 23128226
esv2717948 CNV Deletion 23290073
esv2669455 CNV Deletion 23128226
dgv3657n71 CNV Loss 21882294

Variation tolerance for FZR1 Gene

Residual Variation Intolerance Score: 8.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FZR1 Gene

HapMap Linkage Disequilibrium report
FZR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FZR1 Gene

Disorders for FZR1 Gene

Relevant External Links for FZR1

Genetic Association Database (GAD)
FZR1
Human Genome Epidemiology (HuGE) Navigator
FZR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FZR1
genes like me logo Genes that share disorders with FZR1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FZR1 Gene

Publications for FZR1 Gene

  1. Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1. (PMID: 9734353) Fang G. … Kirschner M.W. (Mol. Cell 1998) 2 23 67
  2. Glycolysis: a bioenergetic or a survival pathway? (PMID: 20006513) BolaA+os J.P. … Moncada S. (Trends Biochem. Sci. 2010) 23 67
  3. Damaged DNA-binding protein 1 (DDB1) interacts with Cdh1 and modulates the function of APC/CCdh1. (PMID: 20395298) Lv X.B. … Kang T. (J. Biol. Chem. 2010) 23 67
  4. E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation. (PMID: 20080744) Almeida A. … Moncada S. (Proc. Natl. Acad. Sci. U.S.A. 2010) 23 67
  5. Anaphase-promoting complex/cyclosome-cdh1 mediates the ubiquitination and degradation of TRB3. (PMID: 20064487) Ohoka N. … Hayashi H. (Biochem. Biophys. Res. Commun. 2010) 23 67

Products for FZR1 Gene

Sources for FZR1 Gene

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