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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FZR1 Gene

protein-coding   GIFtS: 64
GCID: GC19P003506

Fizzy/Cell Division Cycle 20 Related 1 (Drosophila)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fizzy/Cell Division Cycle 20 Related 1 (Drosophila)1 2     HCDH12
FZR2 3 5     CDC20-Like 1b2
Cdh1/Hct1 Homolog2 3     Fizzy-Related Protein Homolog2
CDH12 3     FYR3
CDC20-Like Protein 12 3     Fzr3
HCDH2 5     KIAA12423
CDC20C2     hCDH13
FZR22     

External Ids:    HGNC: 248241   Entrez Gene: 513432   Ensembl: ENSG000001053257   OMIM: 6036195   UniProtKB: Q9UM113   

Export aliases for FZR1 gene to outside databases

Previous GC identifers: GC19P003598 GC19P003446 GC19P003457 GC19P003473 GC19P003272


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FZR1 Gene: 
FZR1 (fizzy/cell division cycle 20 related 1 (Drosophila)) is a protein-coding gene. Diseases associated with FZR1 include cleidocranial dysplasia, and cytomegalovirus infection, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase. GO annotations related to this gene include protein binding. An important paralog of this gene is CDC20.

UniProtKB/Swiss-Prot: FZR_HUMAN, Q9UM11
Function: Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers
substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and
activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure
that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is
phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA
damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1,
preventing entry into mitosis

Gene Wiki entry for FZR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011255.14  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FZR1 gene promoter:
         PPAR-alpha   Elk-1   NRF-2   FOXF2   AP-4   AP-2gamma   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): FZR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FZR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FZR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

FZR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZR1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P003506:  view genomic region     (about GC identifiers)

Start:
3,506,271 bp from pter      End:
3,538,328 bp from pter
Size:
32,058 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FZR_HUMAN, Q9UM11 (See protein sequence)
Recommended Name: Fizzy-related protein homolog  
Size: 496 amino acids; 55179 Da
Subunit: The unphosphorylated form interacts with APC/C during mitosis. Interacts with NINL. Interacts (in complex
with the anaphase promoting complex APC) with MAD2L2; inhibits FZR1-mediated APC/C activation. Interacts with
USP37. Interacts (via WD repeats) with MAK
Subcellular location: Isoform 2: Nucleus
Subcellular location: Isoform 3: Cytoplasm
Sequence caution: Sequence=AAD26623.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of
unknown origin in the C-terminal part; Sequence=AAD26624.1; Type=Miscellaneous discrepancy; Note=Contaminating
sequence. Sequence of unknown origin in the N-terminal part; Sequence=BAA86556.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened;
Secondary accessions: O75869 Q86U66 Q96NW8 Q9UI96 Q9ULH8 Q9UM10 Q9UNQ1 Q9Y2T8
Alternative splicing: 3 isoforms:  Q9UM11-1   Q9UM11-2   Q9UM11-3   (Minor)

Explore the universe of human proteins at neXtProt for FZR1: NX_Q9UM11

Explore proteomics data for FZR1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated during mitosis, probably by maturation promoting factor (MPF), leading to its dissociation of the
    APC/C. Following DNA damage, it is dephosphorylated by CDC14B in G2 phase, leading to its reassociation with the
    APC/C, and allowing an efficient G2 DNA damage checkpoint. Phosphorylated by MAK
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UM11

  • FZR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FZR1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001129669.1  NP_001129670.1  NP_057347.2  

    ENSEMBL proteins: 
     ENSP00000410369   ENSP00000467967   ENSP00000378529   ENSP00000321800  
    Reactome Protein details: Q9UM11
    Human Recombinant Protein Products for FZR1: 
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    OriGene MassSpec for FZR1 
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    Novus Biologicals FZR1 Proteins
    Novus Biologicals FZR1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FZR1 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005680colocalizes with anaphase-promoting complex IDA11459825
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol TAS--

    FZR1 for ontologies           About GeneDecksing



    FZR1 Antibody Products: 
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    Assay Products for FZR1: 
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    Cloud-Clone Corp. ELISAs for FZR1 
    Cloud-Clone Corp. CLIAs for FZR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UM11

    ProtoNet protein and cluster: Q9UM11

    2 Blocks protein domains:
    IPB000002 Cdc20/Fizzy
    IPB001680 G-protein beta WD-40 repeat signature


    UniProtKB/Swiss-Prot: FZR_HUMAN, Q9UM11
    Similarity: Belongs to the WD repeat CDC20/Fizzy family
    Similarity: Contains 7 WD repeats


    FZR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FZR_HUMAN, Q9UM11
    Function: Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers
    substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and
    activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure
    that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is
    phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA
    damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1,
    preventing entry into mitosis

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11459826
         
    FZR1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FZR1:
     Decreased nuclei size in G2M  Increased cell death in breast 

         11 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Fzr1):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size 
     hematopoietic system  homeostasis/metabolism  mortality/aging  nervous system  no phenotypic analysis 
     tumorigenesis 

    FZR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FZR1: Fzr1tm1.2Stge Fzr1tm1.1Mama

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FZR1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FZR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FZR1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FZR1 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate FZR1:
    hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmidFZR1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): FZR1 (NM_016263)
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                         Customized lentivirus expression plasmids for stable overexpression of FZR1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZR1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FZR1 About   (see all 15)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase0.75
    Common schema of ubiquitination0.36
    3CDK-mediated phosphorylation and removal of Cdc6
    Regulation of APC/C activators between G1/S and early anaphase0.94
    Regulation of DNA replication0.89
    APC/C-mediated degradation of cell cycle proteins0.94
    Orc1 removal from chromatin0.89
    Regulation of mitotic cell cycle0.94
    Switching of origins to a post-replicative state0.89
    APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G10.93
    Cyclin A:Cdk2-associated events at S phase entry0.88
    4Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    5Immune System
    Immune System0.56
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for FZR1
        Cell cycle Role of APC in cell cycle regulation
    Common schema of ubiquitination
    Cell cycle Regulation of G1/S transition (part 1)
    Development TGF-beta receptor signaling
    Cell cycle Role of SCF complex in cell cycle regulation

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for FZR1
        Mitotic Roles of Polo Like Kinases

    4 GeneGo (Thomson Reuters) Pathways for FZR1
        Cell cycle Role of APC in cell cycle regulation
    Cell cycle Regulation of G1/S transition (part 1)
    Development TGF-beta receptor signaling
    Cell cycle Role of SCF complex in cell cycle regulation

    3 BioSystems Pathways for FZR1
        TGF-beta Receptor Signaling Pathway
    PLK1 signaling events
    Aurora A signaling


    5/22        Reactome Pathways for FZR1 (see all 22)
        SCF-beta-TrCP mediated degradation of Emi1
    DNA Replication
    Removal of licensing factors from origins
    Cell Cycle
    Orc1 removal from chromatin


    3         Kegg Pathways  (Kegg details for FZR1):
        Cell cycle
    Ubiquitin mediated proteolysis
    Progesterone-mediated oocyte maturation

    UniProtKB/Swiss-Prot: FZR_HUMAN, Q9UM11
    Pathway: Protein modification; protein ubiquitination


    FZR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FZR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/208 Interacting proteins for FZR1 (Q9UM111, 2, 3 ENSP000003785294) via UniProtKB, MINT, STRING, and/or I2D (see all 208)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP2Q133091, 3, ENSP000002742554EBI-724997,EBI-456291 I2D: score=4 STRING: ENSP00000274255
    CLSPNQ9HAW41, 3, ENSP000003129954EBI-724997,EBI-1369377 I2D: score=1 STRING: ENSP00000312995
    CDC27P302601, 3EBI-724997,EBI-994813 I2D: score=7 
    DNAJA1P316892, 3MINT-65766 I2D: score=4 
    ENSG00000206353Q154773I2D: score=1 
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006281DNA repair IEA--
    GO:0007067mitosis IEA--
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS--

    FZR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FZR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FZR1 (FZR)

    1 Novoseek inferred chemical compound relationship for FZR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 4.24 1 12560341 (1)

    Search CenterWatch for drugs/clinical trials and news about FZR1 / FZR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FZR1 gene (3 alternative transcripts): 
    NM_001136197.1  NM_001136198.1  NM_016263.3  

    Unigene Cluster for FZR1:

    Fizzy/cell division cycle 20 related 1 (Drosophila)
    Hs.413133  [show with all ESTs]
    Unigene Representative Sequence: AB033068
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000441788(uc002lxt.2) ENST00000588327 ENST00000591290 ENST00000395095(uc010dtk.2)
    ENST00000313639(uc002lxv.2) ENST00000592214 ENST00000586212 ENST00000588084

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    Inhib. RNA
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    Additional mRNA sequence: 

    AB013462.1 AB013463.1 AB033068.1 AF080397.1 AF083810.1 AF102507.1 AF102508.1 AF433157.1 
    AK125508.1 BC013413.2 BC111760.1 BT007115.1 

    12 DOTS entries:

    DT.87015162  DT.447888  DT.95172412  DT.121490009  DT.95172410  DT.95296036  DT.100030391  DT.101958792 
    DT.95367053  DT.40248005  DT.452780  DT.95172415 

    24/187 AceView cDNA sequences (see all 187):

    AW013841 BF057455 BQ670336 AF433157 AB033068 BM725772 BI261857 BQ920575 
    BQ950679 BM987892 BM907974 BQ962474 AW070837 F09218 BF059508 AI284384 
    BQ061338 BQ890485 BM462011 NM_016263 BU540935 AL119175 AL119174 BQ061409 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FZR1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b · 14c
    SP1:                                                                                            -     -           -                     
    SP2:                                                                                            -     -                                 
    SP3:                                            -     -                                         -     -           -                     
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for FZR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FZR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTACATATG
    FZR1 Expression
    About this image


    See FZR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FZR1

    SOURCE GeneReport for Unigene cluster: Hs.413133

    UniProtKB/Swiss-Prot: FZR_HUMAN, Q9UM11
    Tissue specificity: Isoform 2 is expressed at high levels in heart, liver, spleen and some cancer cell lines
    whereas isoform 3 is expressed only at low levels in these tissues

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FZR1 gene from 9/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fzr11 , 5 fizzy/cell division cycle 20 related 1 (Drosophila)1, 5 88.03(n)1
    98.38(a)1
      10 (39.72 cM)5
    563711  NM_019757.11  NP_062731.11 
     813662225 
    chicken
    (Gallus gallus)
    Aves FZR16
    Uncharacterized protein
    98(a)
    1 ↔ 1
    28(1070518-1077907)
    African clawed frog
    (Xenopus laevis)
    Amphibia fzr1-prov2 frizzy-related protein 1 (Drosophila) 77.02(n)    BC045037.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc554502 hypothetical protein MGC55450 77.07(n)   393223  BC048038.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta rap1 , 3 cyclin catabolism3
    retina aberrant in pattern1
    68(a)
    (best of 2)3
    66.24(n)1
    71.67(a)1
      459221  NM_080113.21  NP_524852.21 
    worm
    (Caenorhabditis elegans)
    Secernentea fzr-11 Protein FZR-1 57.25(n)
    66.3(a)
      174516  NM_063674.3  NP_496075.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDH11 Cdh1p 48.07(n)
    44.21(a)
      852881   NP_011512.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons FZR31 protein FIZZY-related 3 55.08(n)
    59.52(a)
      831230  NM_001203376.1  NP_001190305.1 
    rice
    (Oryza sativa)
    Liliopsida AK109536.12   -- 72.79(n)    AK109536.1 


    ENSEMBL Gene Tree for FZR1 (if available)
    TreeFam Gene Tree for FZR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FZR1 gene
    CDC202  CDC20B2  
    3 SIMAP similar genes for FZR1 using alignment to 2 protein entries:     FZR_HUMAN (see all proteins):
    WDR19    CDC20B    CDC20

    FZR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/786 SNPs in FZR1 are shown (see all 786)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1134130631,2
    C--3504562(+) TGCGCG/TCCAGC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs591137111,2
    C,F--3504709(+) CTCACG/AGCCAT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1150983731,2
    F--3504779(+) CTGATC/ACCCCT 1 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1166687461,2
    F--3504795(+) AGCCCT/CTGGCA 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs735259781,2
    C,F--3504829(+) TATGGT/ATTTGC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1903201441,2
    --3504928(+) CATCCA/TATCTG 1 -- us2k10--------
    rs81094651,2
    C,F--3505052(+) tgttaT/Cgaata 1 -- us2k15Minor allele frequency- C:0.37WA CSA 125
    rs1998828021,2
    C--3505103(+) GTTAC-/ATGTTTG 1 -- us2k10--------
    rs1382176591,2
    --3505125(+) GTAGAC/TACCTA 1 -- us2k10--------
    rs2011987211,2
    C--3505143(+) ACTGC-/TGTGT 
            
    TGTGT
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FZR1 (3506271 - 3538328 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/20 variations for FZR1 (see all 20):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2663038CNV Deletion23128226
    esv2717946CNV Deletion23290073
    esv2669455CNV Deletion23128226
    esv2717947CNV Deletion23290073
    dgv613e199CNV Deletion23128226
    esv2675938CNV Deletion23128226
    esv2717948CNV Deletion23290073
    nsv910745CNV Loss21882294
    dgv3652n71CNV Loss21882294
    nsv910723CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603619    OMIM disorders: --

    10 diseases for FZR1:    About MalaCards
    cleidocranial dysplasia    cytomegalovirus infection    retinoblastoma    b-cell lymphomas
    neuroblastoma    prostatitis    hepatocellular carcinoma    prostate cancer
    breast cancer    neuronitis


    FZR1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FZR1
    Human Genome Epidemiology (HuGE) Navigator: FZR1 (1 document)

    Export disorders for FZR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FZR1 gene, integrated from 9 sources (see all 150):
    (articles sorted by number of sources associating them with FZR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1. (PubMed id 9734353)1, 2, 3, 9 Fang G.... Kirschner M.W. (1998)
    2. Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family. (PubMed id 9811605)1, 2, 9 Kramer E.R.... Peters J.-M. (1998)
    3. MAD2B is an inhibitor of the anaphase-promoting complex. (PubMed id 11459826)1, 2, 9 Chen J. and Fang G. (2001)
    4. Cell cycle-dependent expression of centrosomal ninein-like protein in human cells is regulated by the anaphase-promoting complex. (PubMed id 17403670)1, 2, 9 Wang Y. and Zhan Q. (2007)
    5. Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/C(CDH1). (PubMed id 21986944)1, 2 Wang L.Y. and Kung H.J. (2012)
    6. Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. (PubMed id 21596315)1, 2 Huang X.... Dixit V.M. (2011)
    7. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    8. The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. (PubMed id 18662541)1, 2 Bassermann F....Pagano M. (2008)
    9. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51343 HGNC: 24824 AceView: FZR1 Ensembl:ENSG00000105325 euGenes: HUgn51343
    ECgene: FZR1 Kegg: 51343 H-InvDB: FZR1

    (According to HUGE)
    About This Section
    HUGE: KIAA1242

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FZR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FZR1 gene:
    Search GeneIP for patents involving FZR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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