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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FZR1 Gene

protein-coding GIFtS: 63
GCID: GC19P003506

fizzy/cell division cycle 20 related 1 (Drosophila)

Explore 12 diseases affiliated with
FZR1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Fizzy/Cell Division Cycle 20 Related 1 (Drosophila)¹ ²		Cdh1/Hct1 Homolog² ³
FZR¹ ² ³ ⁵		CDC20-Like Protein 1² ³
CDH1¹ ² ³		CDC20-Like 1b²
HCDH¹ ² ⁵		Fizzy-Related Protein Homolog²
CDC20C¹ ²		FYR³
FZR2¹ ²		Fzr³
HCDH1¹ ²		HCDH1¹ ²
KIAA1242¹ ³

External Ids:	HGNC: 24824¹	Entrez Gene: 51343²	Ensembl: ENSG00000105325⁷	OMIM: 603619⁵	UniProtKB: Q9UM11³

Export aliases for FZR1 gene to outside databases

Previous GC identifers: GC19P003598 GC19P003446 GC19P003457 GC19P003473 GC19P003272

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: FZR_HUMAN, Q9UM11

Function: Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate

specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the

APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive

regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to

its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its

dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis

Gene Wiki entry for FZR1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011255.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FZR1 gene promoter:
PPAR-alpha Elk-1 NRF-2 FOXF2 AP-4 AP-2gamma ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): FZR1 promoter sequence

Search SABiosciences Chromatin IP Primers for FZR1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FZR1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3

FZR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZR1 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P003506: view genomic region (about GC identifiers)

Start:	3,506,271 bp from pter	End:	3,538,328 bp from pter
Size:	32,058 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FZR_HUMAN, Q9UM11 (See protein sequence)

Recommended Name: Fizzy-related protein homolog

Size: 496 amino acids; 55179 Da

Subunit: The unphosphorylated form interacts with APC/C during mitosis. Interacts with NINL. Interacts (in complex with

the anaphase promoting complex APC) with MAD2L2; inhibits FZR1-mediated APC/C activation. Interacts with USP37.

Interacts (via WD repeats) with MAK

Subcellular location: Isoform 2: Nucleus

Subcellular location: Isoform 3: Cytoplasm

Sequence caution: Sequence=AAD26623.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown

origin in the C-terminal part; Sequence=AAD26624.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.

Sequence of unknown origin in the N-terminal part; Sequence=BAA86556.1; Type=Erroneous initiation; Note=Translation

N-terminally shortened;

Secondary accessions: O75869 Q86U66 Q96NW8 Q9UI96 Q9ULH8 Q9UM10 Q9UNQ1 Q9Y2T8

Alternative splicing: 3 isoforms: Q9UM11-1 Q9UM11-2 Q9UM11-3 (Minor)

Explore the universe of human proteins at neXtProt for FZR1: NX_Q9UM11

Post-translational modifications:

Phosphorylated during mitosis, probably by maturation promoting factor (MPF), leading to its dissociation of the APC/C.

Following DNA damage, it is dephosphorylated by CDC14B in G2 phase, leading to its reassociation with the APC/C, and

allowing an efficient G2 DNA damage checkpoint. Phosphorylated by MAK¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UM11

FZR1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001129669.1 NP_001129670.1 NP_057347.2

ENSEMBL proteins:

ENSP00000410369 ENSP00000467967 ENSP00000378529 ENSP00000321800

Reactome Protein details: Q9UM11
Human Recombinant Protein Products:

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	Uscn Proteins for FZR1

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005680	colocalizes with anaphase-promoting complex	IDA	11459825
GO:0005730	NOT nucleolus	IDA	--
GO:0005829	cytosol	TAS	--

FZR1 for ontologies About GeneDecksing

FZR1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of FZR1
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	Uscn Antibodies for FZR1
	Search ThermoFisher Antibodies for FZR1

Assay Products for FZR1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FZR1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FZR1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FZR1 for domains About GeneDecksing

4 InterPro domains/families:

IPR019775 WD40_repeat_CS

IPR001680 WD40_repeat

IPR017986 WD40_repeat_dom

IPR015943 WD40/YVTN_repeat-like_dom

Graphical View of Domain Structure for InterPro Entry Q9UM11

ProtoNet protein and cluster: Q9UM11

2 Blocks protein families:

IPB000002 Cdc20/Fizzy

IPB001680 G-protein beta WD-40 repeat signature

UniProtKB/Swiss-Prot: FZR_HUMAN, Q9UM11

Similarity: Belongs to the WD repeat CDC20/Fizzy family

Similarity: Contains 7 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FZR_HUMAN, Q9UM11

Function: Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate

specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the

APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive

regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to

its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its

dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis

miRNA Products:		miRTarBase miRNAs that target FZR1: hsa-mir-9 (MIRT000029)

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		hsa-miR-466
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Gene Editing
Products:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZR1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--

FZR1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for FZR1:

Decreased nuclei size in G2M

Increased cell death in breast

Animal Models:
Mouse knock-outs for FZR1: Fzr1^tm1.2Stge Fzr1^tm1.1Mama
11 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Fzr1):

behavior/neurological	cardiovascular system	cellular	embryogenesis	growth/size
hematopoietic system	homeostasis/metabolism	mortality/aging	nervous system	no phenotypic analysis
tumorigenesis

FZR1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/18 pathways (see all 18)
SCF-mediated degradation of Emi1	0.87	Regulation of DNA replication	0.68
SCF-beta-TrCP mediated degradation of Emi1	0.87	Removal of licensing factors from origins	0.68
APC/C:Cdh1-mediated degradation of Skp2	0.74	Cyclin A:Cdk2-associated events at S phase entry	0.66
Autodegradation of Cdh1 by Cdh1:APC/C	0.70	Regulation of APC/C activators between G1/S and early anaphase	0.62

Antigen processing: Ubiquitination & Proteasome degradation

	Antigen processing: Ubiquitination & Proteasome degradation	1.00			Polyubiquitination of substrate	0.75
	Class I MHC mediated antigen processing & presentation	0.83			Ubiquitin mediated proteolysis	0.36

Cell cycle_Role of SCF complex in cell cycle regulation

Cell cycle_Role of SCF complex in cell cycle regulation

1.00

Cell cycle Role of SCF complex in cell cycle regulation

0.98

Development_TGF-beta receptor signaling

Development_TGF-beta receptor signaling

1.00

Development TGF-beta receptor signaling

0.96

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for FZR1

	Cell cycle Role of APC in cell cycle regulation
	Common schema of ubiquitination
	Cell cycle Regulation of G1/S transition (part 1)
	Development TGF-beta receptor signaling
	Cell cycle Role of SCF complex in cell cycle regulation

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for FZR1

Mitotic Roles of Polo Like Kinases

4 GeneGo (Thomson Reuters) Pathways for FZR1

	Cell cycle Role of APC in cell cycle regulation
	Cell cycle Regulation of G1/S transition (part 1)
	Development TGF-beta receptor signaling
	Cell cycle Role of SCF complex in cell cycle regulation

3 BioSystems Pathways for FZR1

	TGF-beta Receptor Signaling Pathway
	PLK1 signaling events
	Aurora A signaling

5/27 Reactome Pathways for FZR1 (see all 27)

	SCF-beta-TrCP mediated degradation of Emi1
	SCF-mediated degradation of Emi1
	DNA Replication
	Removal of licensing factors from origins
	Cell Cycle

3 Kegg Pathways (Kegg details for FZR1):

	Cell cycle
	Ubiquitin mediated proteolysis
	Progesterone-mediated oocyte maturation

UniProtKB/Swiss-Prot: FZR_HUMAN, Q9UM11

Pathway: Protein modification; protein ubiquitination

FZR1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FZR1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/203 Interacting proteins for FZR1 (Q9UM11^{1, 2, 3} ENSP00000378529⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 203)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SKP2	Q13309¹^,³, ENSP00000274255⁴	EBI-2558941,EBI-456291 I2D: score=4 STRING: ENSP00000274255
CLSPN	Q9HAW4¹^,³, ENSP00000312995⁴	EBI-2558941,EBI-1369377 I2D: score=1 STRING: ENSP00000312995
CDC27	P30260¹^,³	EBI-2558941,EBI-994813 I2D: score=7
DNAJA1	P31689²^,³	MINT-65766 I2D: score=4
RAD17	O75943²^,³, ENSP00000370151⁴	MINT-7897581 MINT-7897592 I2D: score=1 STRING: ENSP00000370151

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000084	S phase of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0006281	DNA repair	IEA	--
GO:0007067	mitosis	IEA	--
GO:0008284	positive regulation of cell proliferation	IEA	--

FZR1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FZR1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FZR1
1 Novoseek chemical compound relationship for FZR1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
serine	4.24	1	12560341 (1)

Search CenterWatch for drugs/clinical trials and news about FZR1 / FZR

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FZR1 gene (3 alternative transcripts):

NM_001136197.1 NM_001136198.1 NM_016263.3

Unigene Cluster for FZR1:

Fizzy/cell division cycle 20 related 1 (Drosophila)

Hs.413133 [show with all ESTs]

Unigene Representative Sequence: AB033068

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000441788(uc002lxt.2) ENST00000588327 ENST00000591290 ENST00000395095(uc010dtk.2)

ENST00000313639(uc002lxv.2) ENST00000592214 ENST00000586212 ENST00000588084

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		hsa-miR-466
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Additional cDNA sequence:

AB013462.1 AB013463.1 AB033068.1 AF080397.1 AF083810.1 AF102507.1 AF102508.1 AF433157.1

AK125508.1 BC013413.2 BC111760.1 BT007115.1

11 DOTS entries:

DT.87015162 DT.447888 DT.95172412 DT.121490009 DT.95172410 DT.95296036 DT.100030391 DT.101958792

DT.40248005 DT.95172415 DT.95367053

24/187 AceView cDNA sequences (see all 187):

AW070837 BQ890485 BQ962474 BF057455 BM987892 BM725772 BQ061338 CB044099

AI284384 BQ670336 BQ950679 AB033068 BU931682 BM462011 AW015088 BC013413

AL119174 BQ939749 NM_016263 BU540935 BE263129 AF083810 BQ920575 AW025992

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FZR1 (see all 6) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b	·	13c	^	14a	·	14b	·	14c
SP1:																															-		-				-
SP2:																															-		-
SP3:															-		-														-		-				-
SP4:
SP5:

ECgene alternative splicing isoforms for FZR1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FZR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTACATATG

About this image

FZR1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FZR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FZR1

SOURCE GeneReport for Unigene cluster: Hs.413133

UniProtKB/Swiss-Prot: FZR_HUMAN, Q9UM11

Tissue specificity: Isoform 2 is expressed at high levels in heart, liver, spleen and some cancer cell lines whereas

isoform 3 is expressed only at low levels in these tissues

SABiosciences Custom PCR Arrays for FZR1

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FZR1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZR1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for FZR1 gene from 8/37 species (see all 37) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FZR1⁶	fizzy/cell division cycle 20 related 1	90(a)	1 ↔ 1	Un(44473341-44485265)
African clawed frog (Xenopus laevis)	Amphibia	fzr1-prov²	frizzy-related protein 1 (Drosophila)	77.02(n)		BC045037.1
zebrafish (Danio rerio)	Actinopterygii	zgc55450²	hypothetical protein MGC55450	77.07(n)		393223 BC048038.1
fruit fly (Drosophila melanogaster)	Insecta	rap^{1 , 3}	cyclin catabolism³ retina aberrant in pattern¹	68(a) (best of 2)³ 66.24(n)¹ 71.67(a)¹		45922¹ NM_080113.2¹ NP_524852.2¹
worm (Caenorhabditis elegans)	Secernentea	fzr-1¹	Protein FZR-1	57.25(n) 66.3(a)		174516 NM_063674.3 NP_496075.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	CDH1¹	Cdh1p	48.07(n) 44.21(a)		852881 NP_011512.1
thale cress (Arabidopsis thaliana)	eudicotyledons	FZR3¹	protein FIZZY-related 3	55.08(n) 59.52(a)		831230 NM_001203376.1 NP_001190305.1
rice (Oryza sativa)	Liliopsida	AK109536.1²	--	72.79(n)		AK109536.1

ENSEMBL Gene Tree for FZR1 (if available)
TreeFam Gene Tree for FZR1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs28454918^1,2		--	3295289(+)	`GATGCA/GAGAGT`	1	--	int¹		0	--	--	--	--
rs59113711^1,2	C,	--	3504709(+)	`CTCACG/AGCCAT`	1	--	us2k¹		1		WA	2
rs115098373^1,2	F,	--	3504779(+)	`CTGATC/ACCCCT`	1	--	us2k¹		1		WA	118
rs116668746^1,2		--	3504795(+)	`AGCCCT/CTGGCA`	1	--	us2k¹		1		WA	118
rs73525978^1,2	C,	--	3504829(+)	`TATGGT/ATTTGC`	1	--	us2k¹		1		WA	2
rs190320144^1,2		--	3504928(+)	`CATCCA/TATCTG`	1	--	us2k¹		0	--	--	--	--
rs8109465^1,2	C,F,	--	3505052(+)	`tgttaT/Cgaata`	1	--	us2k¹		5		WA CSA	125
rs199882802^1,2		--	3505103(+)	`GTTAC-/ATGTTTG`	1	--	us2k¹		0	--	--	--	--
rs138217659^1,2		--	3505125(+)	`GTAGAC/TACCTA`	1	--	us2k¹		0	--	--	--	--
rs201198721^1,2		--	3505143(+)	`ACTGC-/TGTGT TGTGT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FZR1 (3506271 - 3538328 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for FZR1
4 CNVs: 73290 30067 30069 30068

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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FZR1 for disorders           About GeneDecksing

OMIM gene information: 603619    OMIM disorders: --

12 diseases for FZR1:    About MalaCards

cleidocranial dysplasia b-cell lymphomas hepatocellular carcinoma prostate carcinoma

breast cancer carcinoma neuroblastoma prostatitis

malaria neuronitis retinoblastoma prostate cancer

Human Genome Epidemiology (HuGE) Navigator: FZR1 (1 document)

Export disorders for FZR1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FZR1 gene, integrated from 9 sources (see all 138):
(articles sorted by number of sources associating them with FZR1)

Utopia: connect your pdf to the dynamic
world of online information

Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1. (PubMed id 9734353)^{1, 2, 3, 9} Fang G.... Kirschner M.W. (1998)
Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family. (PubMed id 9811605)^{1, 2, 9} Kramer E.R.... Peters J.-M. (1998)
MAD2B is an inhibitor of the anaphase-promoting complex. (PubMed id 11459826)^{1, 2, 9} Chen J. and Fang G. (2001)
Cell cycle-dependent expression of centrosomal ninein-like protein in human cells is regulated by the anaphase-promoting complex. (PubMed id 17403670)^{1, 2, 9} Wang Y. and Zhan Q. (2007)
Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/C(CDH1). (PubMed id 21986944)^{1, 2} Wang L.Y. and Kung H.J. (2012)
Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. (PubMed id 21596315)^{1, 2} Huang X.... Dixit V.M. (2011)
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. (PubMed id 18662541)^{1, 2} Bassermann F....Pagano M. (2008)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Differential expression, localization and activity of two alternatively spliced isoforms of human APC regulator CDH1. (PubMed id 12797865)^{1, 2} Zhou Y.... Jin D.-Y. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 51343	HGNC: 24824	AceView: FZR1	Ensembl:ENSG00000105325	euGenes: HUgn51343
ECgene: FZR1	Kegg: 51343	H-InvDB: FZR1

(According to HUGE)
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HUGE: KIAA1242

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FZR1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FZR1 gene
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Patent Information for FZR1 gene:
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fizzy/cell division cycle 20 related 1 (Drosophila)

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fizzy/cell division cycle 20 related 1 (Drosophila)

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