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Aliases for FZR1 Gene

Aliases for FZR1 Gene

  • Fizzy/Cell Division Cycle 20 Related 1 2 3 5
  • CDC20-Like Protein 1 3 4
  • Cdh1/Hct1 Homolog 3 4
  • CDC20 Homolog 1 2 3
  • HCDH1 3 4
  • CDH1 3 4
  • FZR 3 4
  • Fizzy/Cell Division Cycle 20 Related 1 (Drosophila) 2
  • Fizzy-Related Protein Homolog 3
  • CDC20-Like 1b 3
  • KIAA1242 4
  • CDC20C 3
  • FZR2 3
  • HCDH 3
  • FYR 4

External Ids for FZR1 Gene

Previous GeneCards Identifiers for FZR1 Gene

  • GC19P003598
  • GC19P003446
  • GC19P003457
  • GC19P003473
  • GC19P003272

Summaries for FZR1 Gene

GeneCards Summary for FZR1 Gene

FZR1 (Fizzy/Cell Division Cycle 20 Related 1) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Cell cycle Role of SCF complex in cell cycle regulation. An important paralog of this gene is CDC20.

UniProtKB/Swiss-Prot for FZR1 Gene

  • Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Gene Wiki entry for FZR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FZR1 Gene

Genomics for FZR1 Gene

Regulatory Elements for FZR1 Gene

Enhancers for FZR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FZR1 on UCSC Golden Path with GeneCards custom track

Promoters for FZR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FZR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FZR1 Gene

Chromosome:
19
Start:
3,506,065 bp from pter
End:
3,538,539 bp from pter
Size:
32,475 bases
Orientation:
Plus strand

Genomic View for FZR1 Gene

Genes around FZR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FZR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FZR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FZR1 Gene

Proteins for FZR1 Gene

  • Protein details for FZR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UM11-FZR_HUMAN
    Recommended name:
    Fizzy-related protein homolog
    Protein Accession:
    Q9UM11
    Secondary Accessions:
    • O75869
    • Q86U66
    • Q96NW8
    • Q9UI96
    • Q9ULH8
    • Q9UM10
    • Q9UNQ1
    • Q9Y2T8

    Protein attributes for FZR1 Gene

    Size:
    496 amino acids
    Molecular mass:
    55179 Da
    Quaternary structure:
    • The unphosphorylated form interacts with APC/C during mitosis. Interacts with NINL. Interacts (in complex with the anaphase promoting complex APC) with MAD2L2; inhibits FZR1-mediated APC/C activation. Interacts with SIRT2 and USP37. Interacts (via WD repeats) with MAK.
    SequenceCaution:
    • Sequence=AAD26623.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305}; Sequence=AAD26624.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BAA86556.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FZR1 Gene

    Alternative splice isoforms for FZR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FZR1 Gene

Post-translational modifications for FZR1 Gene

  • Acetylated. Deacetylated by SIRT2 at Lys-69 and Lys-159; deacetylation enhances the interaction of FZR1 with CDC27, leading to activation of anaphase promoting complex/cyclosome (APC/C).
  • Phosphorylated during mitosis, probably by maturation promoting factor (MPF), leading to its dissociation of the APC/C. Following DNA damage, it is dephosphorylated by CDC14B in G2 phase, leading to its reassociation with the APC/C, and allowing an efficient G2 DNA damage checkpoint. Phosphorylated by MAK.
  • Ubiquitination at Lys 135 and Lys 263
  • Modification sites at PhosphoSitePlus

Other Protein References for FZR1 Gene

No data available for DME Specific Peptides for FZR1 Gene

Domains & Families for FZR1 Gene

Gene Families for FZR1 Gene

Suggested Antigen Peptide Sequences for FZR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UM11

UniProtKB/Swiss-Prot:

FZR_HUMAN :
  • Belongs to the WD repeat CDC20/Fizzy family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat CDC20/Fizzy family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with FZR1: view

Function for FZR1 Gene

Molecular function for FZR1 Gene

UniProtKB/Swiss-Prot Function:
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Gene Ontology (GO) - Molecular Function for FZR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11459826
GO:0010997 anaphase-promoting complex binding IEA --
GO:0097027 ubiquitin-protein transferase activator activity IEA --
genes like me logo Genes that share ontologies with FZR1: view
genes like me logo Genes that share phenotypes with FZR1: view

Animal Models for FZR1 Gene

MGI Knock Outs for FZR1:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for FZR1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FZR1 Gene

Localization for FZR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FZR1 Gene

Isoform 2: Nucleus.
Isoform 3: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FZR1 Gene COMPARTMENTS Subcellular localization image for FZR1 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FZR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005680 colocalizes_with anaphase-promoting complex IDA 11459825
GO:0005829 cytosol TAS --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with FZR1: view

Pathways & Interactions for FZR1 Gene

genes like me logo Genes that share pathways with FZR1: view

UniProtKB/Swiss-Prot Q9UM11-FZR_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FZR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS --
GO:0031572 G2 DNA damage checkpoint IDA 18662541
genes like me logo Genes that share ontologies with FZR1: view

No data available for SIGNOR curated interactions for FZR1 Gene

Drugs & Compounds for FZR1 Gene

(1) Drugs for FZR1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with FZR1: view

Transcripts for FZR1 Gene

Unigene Clusters for FZR1 Gene

Fizzy/cell division cycle 20 related 1 (Drosophila):
Representative Sequences:

CRISPR Products

Clone Products

  • Addgene plasmids for FZR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FZR1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b · 14c
SP1: - - -
SP2: - -
SP3: - - - - -
SP4:
SP5:
SP6: -

Relevant External Links for FZR1 Gene

GeneLoc Exon Structure for
FZR1
ECgene alternative splicing isoforms for
FZR1

Expression for FZR1 Gene

mRNA expression in normal human tissues for FZR1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FZR1 Gene



NURSA nuclear receptor signaling pathways regulating expression of FZR1 Gene:

FZR1

SOURCE GeneReport for Unigene cluster for FZR1 Gene:

Hs.413133

mRNA Expression by UniProt/SwissProt for FZR1 Gene:

Q9UM11-FZR_HUMAN
Tissue specificity: Isoform 2 is expressed at high levels in heart, liver, spleen and some cancer cell lines whereas isoform 3 is expressed only at low levels in these tissues.
genes like me logo Genes that share expression patterns with FZR1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for FZR1 Gene

Orthologs for FZR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FZR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FZR1 34
  • 90.53 (n)
  • 98.99 (a)
FZR1 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FZR1 34
  • 91.28 (n)
  • 98.78 (a)
FZR1 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fzr1 34
  • 88.03 (n)
  • 98.38 (a)
Fzr1 16
Fzr1 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fzr1 34
  • 87.63 (n)
  • 97.97 (a)
oppossum
(Monodelphis domestica)
Mammalia FZR1 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FZR1 35
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FZR1 35
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDH1-A 34
  • 83.37 (n)
  • 97.57 (a)
CDH1-A 35
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fzr1 34
  • 77.89 (n)
  • 96.35 (a)
Str.20252 34
African clawed frog
(Xenopus laevis)
Amphibia fzr1-prov 34
zebrafish
(Danio rerio)
Actinopterygii fzr1 34
  • 75.81 (n)
  • 91.67 (a)
zgc55450 34
fzr1 35
  • 92 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta fzr2 36
  • 49 (a)
rap 36
  • 68 (a)
rap 34
  • 68.85 (n)
  • 75.79 (a)
fzr2 35
  • 49 (a)
OneToMany
rap 35
  • 71 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002114 34
  • 70.21 (n)
  • 73.98 (a)
worm
(Caenorhabditis elegans)
Secernentea fzr-1 34
  • 57.43 (n)
  • 66.3 (a)
fzr-1 35
  • 38 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL007C 34
  • 52.3 (n)
  • 50.15 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A08822g 34
  • 48.29 (n)
  • 49.56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDH1 34
  • 48.84 (n)
  • 45.39 (a)
CDH1 35
  • 34 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons FZR3 34
  • 55.45 (n)
  • 59.51 (a)
soybean
(Glycine max)
eudicotyledons Gma.12561 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3232 34
barley
(Hordeum vulgare)
Liliopsida Hv.6041 34
rice
(Oryza sativa)
Liliopsida Os01g0972900 34
  • 57.03 (n)
  • 57.82 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.27562 34
corn
(Zea mays)
Liliopsida Zm.14057 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4550 34
bread mold
(Neurospora crassa)
Ascomycetes NCU01269 34
  • 58.06 (n)
  • 60.23 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes srw1 34
  • 50.16 (n)
  • 51.87 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 66 (a)
OneToOne
Species where no ortholog for FZR1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for FZR1 Gene

ENSEMBL:
Gene Tree for FZR1 (if available)
TreeFam:
Gene Tree for FZR1 (if available)

Paralogs for FZR1 Gene

Paralogs for FZR1 Gene

(3) SIMAP similar genes for FZR1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FZR1: view

Variants for FZR1 Gene

Sequence variations from dbSNP and Humsavar for FZR1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3040391 -- 3,534,227(-) ttttt(-/TTT)aattt intron-variant
rs3180190 -- 3,533,308(+) CACGG(C/G/T)TACTC nc-transcript-variant, reference, synonymous-codon
rs3746129 -- 3,523,797(-) AGCTG(C/T)GATGG intron-variant
rs3760998 -- 3,521,013(-) GGACA(C/T)GCCCT intron-variant, upstream-variant-2KB
rs3760999 -- 3,520,564(-) TGGTA(A/G)TGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FZR1 Gene

Variant ID Type Subtype PubMed ID
dgv613e199 CNV deletion 23128226
esv2663038 CNV deletion 23128226
esv2669455 CNV deletion 23128226
esv2675938 CNV deletion 23128226
esv26869 CNV loss 19812545
esv2717946 CNV deletion 23290073
esv2717947 CNV deletion 23290073
esv2717948 CNV deletion 23290073
esv3364166 CNV insertion 20981092
nsv470114 CNV loss 18288195
nsv953948 CNV deletion 24416366

Variation tolerance for FZR1 Gene

Residual Variation Intolerance Score: 8.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FZR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FZR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FZR1 Gene

Disorders for FZR1 Gene

Relevant External Links for FZR1

Genetic Association Database (GAD)
FZR1
Human Genome Epidemiology (HuGE) Navigator
FZR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FZR1

No disorders were found for FZR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FZR1 Gene

Publications for FZR1 Gene

  1. Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1. (PMID: 9734353) Fang G. … Kirschner M.W. (Mol. Cell 1998) 2 3 4 22 65
  2. Cell cycle-dependent expression of centrosomal ninein-like protein in human cells is regulated by the anaphase-promoting complex. (PMID: 17403670) Wang Y. … Zhan Q. (J. Biol. Chem. 2007) 3 4 22 65
  3. MAD2B is an inhibitor of the anaphase-promoting complex. (PMID: 11459826) Chen J. … Fang G. (Genes Dev. 2001) 3 4 22 65
  4. Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family. (PMID: 9811605) Kramer E.R. … Peters J.-M. (Curr. Biol. 1998) 3 4 22 65
  5. Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/C(CDH1). (PMID: 21986944) Wang L.Y. … Kung H.J. (Oncogene 2012) 3 4 65

Products for FZR1 Gene

Sources for FZR1 Gene

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