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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FZD9 Gene

protein-coding GIFtS: 69
GCID: GC07P072848

frizzled family receptor 9

(Previous names: frizzled (Drosophila) homolog 9, frizzled homolog 9 (Drosophila),...)

Explore 16 diseases affiliated with
FZD9 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Frizzled Family Receptor 9¹ ²		Frizzled Homolog 9²
FZD3¹ ² ³ ⁵		Frizzled-9¹
CD349¹ ²		Fz-9³
Frizzled 9, Seven Transmembrane Spanning Receptor¹ ²		FzE6³
HFz9¹		Fz-9³
Frizzled (Drosophila) Homolog 9¹		FzE6³
Frizzled Homolog 9 (Drosophila)¹		CD349 Antigen³

External Ids:	HGNC: 4047¹	Entrez Gene: 8326²	Ensembl: ENSG00000188763⁷	OMIM: 601766⁵	UniProtKB: O00144³

Export aliases for FZD9 gene to outside databases

Previous GC identifers: GC07P071488 GC07P072246 GC07P072260 GC07P072292 GC07P072486 GC07P068729

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FZD9:

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling

proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and

heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed

predominantly in brain, testis, eye, skeletal muscle, and kidney. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FZD9_HUMAN, O00144

Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling

pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of

beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been

seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated

in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways

seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of

polarity information during tissue morphogenesis and/or in differentiated tissues

Gene Wiki entry for FZD9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079593.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FZD9 gene promoter:
AhR TBP Elk-1 PPAR-gamma1 AML1a Nkx2-5 PPAR-gamma2 ATF
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for FZD9

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FZD9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23 Ensembl cytogenetic band: 7q11.23 HGNC cytogenetic band: 7q11.23

FZD9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZD9 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P072848: view genomic region (about GC identifiers)

Start:	72,848,109 bp from pter	End:	72,850,450 bp from pter
Size:	2,342 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 72,181,181-72,183,522

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FZD9_HUMAN, O00144 (See protein sequence)

Recommended Name: Frizzled-9 precursor

Size: 591 amino acids; 64466 Da

Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)

Caution: Has been first described as FZD3 in litterature

Explore the universe of human proteins at neXtProt for FZD9: NX_O00144

Post-translational modifications:

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O00144

FZD9 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003499.1

ENSEMBL proteins:

ENSP00000345785

Reactome Protein details: O00144
Human Recombinant Protein Products:

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	Uscn Proteins for FZD9

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	19038973
GO:0005886	plasma membrane	IDA	19038973
GO:0009986	cell surface	IDA	--
GO:0016021	integral to membrane	IEA	--
GO:0031527	filopodium membrane	IBA	--

FZD9 for ontologies About GeneDecksing

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Assay Products for FZD9:

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	Uscn ELISAs and CLIAs for FZD9

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FZD9 for domains About GeneDecksing

5 InterPro domains/families:

IPR000539 Frizzled

IPR020067 Frizzled_dom

IPR026546 FZD9

IPR015526 Frizzled/SFRP

IPR017981 GPCR_2-like

Graphical View of Domain Structure for InterPro Entry O00144

ProtoNet protein and cluster: O00144

1 Blocks protein family: IPB000539 Frizzled protein signature

UniProtKB/Swiss-Prot: FZD9_HUMAN, O00144

Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the

activation of the Wnt/beta-catenin signaling pathway (By similarity)

Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)

Similarity: Belongs to the G-protein coupled receptor Fz/Smo family

Similarity: Contains 1 FZ (frizzled) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FZD9_HUMAN, O00144

Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling

pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of

beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been

seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated

in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways

seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of

polarity information during tissue morphogenesis and/or in differentiated tissues

Genatlas biochemistry entry for FZD9:

Drosophila frizzled polarity gene homolog,G protein coupled receptor superfamily,exhibiting characteristics of a WNT

receptor,expressed in brain,testis,eye,skeletal muscle,kidney,involved in signal transduction,activating

Dishevelled,located in the WBS1 deletion

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		hsa-miR-499-3p hsa-miR-324-3p hsa-miR-1285 hsa-miR-520a-5p hsa-miR-612 hsa-miR-629 hsa-miR-525-5p hsa-miR-2115

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD9

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0017147	Wnt-protein binding	IPI	19038973
GO:0030165	PDZ domain binding	IBA	--
GO:0042803	protein homodimerization activity	IPI	14688793
GO:0042813	Wnt-activated receptor activity	IBA	--

FZD9 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for FZD9:

Decreased Salmonella enterica

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-outs for FZD9: Fzd9^tm1Sjp Fzd9^tm1Lex Fzd9^tm1Uta
8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Fzd9):

behavior/neurological	cellular	growth/size	hematopoietic system	immune system
mortality/aging	nervous system	skeleton

FZD9 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Wnt Signaling Pathway

Wnt Signaling Pathway	1.00	Wnt signaling pathway	0.30
Wnt Signaling Pathway and Pluripotency	0.55	Wnt Signaling Pathway NetPath	0.22
Wnt Signaling Pathway	0.33

Translation_Non-genomic (rapid) action of Androgen Receptor

Translation_Non-genomic (rapid) action of Androgen Receptor

1.00

Translation Non-genomic (rapid) action of Androgen Receptor

0.99

Transcription_Androgen Receptor nuclear signaling

Transcription_Androgen Receptor nuclear signaling

1.00

Transcription Androgen Receptor nuclear signaling

0.99

Nanog in Mammalian ESC Pluripotency

Nanog in Mammalian ESC Pluripotency

1.00

GSK3 Signaling

0.61

Human Embryonic Stem Cell Pluripotency

Human Embryonic Stem Cell Pluripotency

1.00

Factors Promoting Cardiogenesis in Vertebrates

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for FZD9

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

1 R&D Systems Pathway for FZD9

Wnt Signaling Pathway

5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FZD9 (see all 11)

	Factors Promoting Cardiogenesis in Vertebrates
	Molecular Mechanisms of Cancer
	G12-G13 in Cellular Signaling
	Colorectal Cancer Metastasis
	Glioblastoma Multiforme

2 GeneGo (Thomson Reuters) Pathways for FZD9

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

4 BioSystems Pathways for FZD9

	Wnt Signaling Pathway
	Wnt Signaling Pathway and Pluripotency
	Wnt Signaling Pathway NetPath
	Wnt signaling network

4 Reactome Pathways for FZD9

	Signal Transduction
	Signaling by GPCR
	GPCR ligand binding
	Class B/2 (Secretin family receptors)

4 Kegg Pathways (Kegg details for FZD9):

	Wnt signaling pathway
	Melanogenesis
	Pathways in cancer
	Basal cell carcinoma

FZD9 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FZD9

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/35 Interacting proteins for FZD9 (O00144^{2, 3} ENSP00000345785⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 35)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MDFI	Q99750²^,³, ENSP00000230321⁴	MINT-66133 I2D: score=4 STRING: ENSP00000230321
WNT1	P04628³, ENSP00000293549⁴	I2D: score=1 STRING: ENSP00000293549
WNT2	P09544³, ENSP00000265441⁴	I2D: score=1 STRING: ENSP00000265441
WNT7A	O00755³, ENSP00000285018⁴	I2D: score=1 STRING: ENSP00000285018
LRP6	ENSP00000261349⁴	STRING: ENSP00000261349

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001944	vasculature development	IBA	--
GO:0007399	nervous system development	TAS	9147651
GO:0007405	neuroblast proliferation	IBA	--
GO:0007420	brain development	IBA	--
GO:0007611	learning or memory	IEA	--

FZD9 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FZD9 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FZD9

1 HMDB Compound for FZD9 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

1 Novoseek chemical compound relationship for FZD9 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	8.87	1	15705594 (1)

Search CenterWatch for drugs/clinical trials and news about FZD9

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FZD9 gene:

NM_003508.2

Unigene Cluster for FZD9:

Frizzled family receptor 9

Hs.647029 [show with all ESTs]

Unigene Representative Sequence: BC026333

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000344575(uc003tyb.3)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FZD9
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		hsa-miR-499-3p hsa-miR-324-3p hsa-miR-1285 hsa-miR-520a-5p hsa-miR-612 hsa-miR-629 hsa-miR-525-5p hsa-miR-2115

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FZD9

Additional cDNA sequence:

BC026333.1 U82169.1

1 DOTS entry:

DT.40117792

15 AceView cDNA sequences:

BQ006532 BQ679374 BQ681183 BI915516 BG705632 BX375411 NM_003508 BX369755

U82169 BC026333 BQ678465 BI757995 AW148871 BI918465 BI524304

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FZD9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTAAGACGG

About this image

FZD9 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Metencephalon

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

HyStem+TGF?3+GDF5-induced E15 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

See FZD9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FZD9

SOURCE GeneReport for Unigene cluster: Hs.647029

UniProtKB/Swiss-Prot: FZD9_HUMAN, O00144

Tissue specificity: Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney.

Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and

kidney

SABiosciences Expression via Pathway-Focused PCR Arrays including FZD9:

G Protein Coupled Receptors 384HT in human mouse rat

WNT Signaling Pathway in human mouse rat

Mesenchymal Stem Cell in human mouse rat

Stem Cell Signaling in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FZD9 gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FZD9¹	frizzled family receptor 9	80.61(n) 80.38(a)		373886 XM_425392.3 XP_425392.3
zebrafish (Danio rerio)	Actinopterygii	AF169639.1²	--	79.74(n)		58023 AF169639.1
fruit fly (Drosophila melanogaster)	Insecta	fz4⁶	frizzled 4	22(a)	possible ortholog	X(7000305-7004325)
worm (Caenorhabditis elegans)	Secernentea	mom-5⁶ mig-1⁶	abnormal cell MIGration family member (mig-1)	31(a) 19(a)	possible ortholog possible ortholog	I(9965578-9969403) I(948569-957376)

ENSEMBL Gene Tree for FZD9 (if available)
TreeFam Gene Tree for FZD9 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FZD9 gene

FZD10² FZD3² FZD8² FZD1² FZD5² FZD2² SFRP4² SMO²

FZD4² FZD6² SFRP1² FRZB² FZD7² SFRP5² SFRP2²

10 SIMAP similar genes for FZD9 using alignment to 2 protein entries: FZD9_HUMAN (see all proteins):

FZD10 GPCR FZD4 FZD5 FZD1 FZD7

FZD2 FZD6 FZD3 FZD8

FZD9 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112045978^1,2		--	72179514(+)	`CTATGC/ACCTTG`	1	--	us2k¹		1	CSA	2
rs42120^1,2	C,	--	72179934(-)	`ggtgcG/Catctt`	1	--	us2k¹		1	NA	2
rs1178948^1,2		--	72180555(-)	`tagagA/Tcaggg`	1	--	us2k¹		3	NA WA	122
rs1183189^1,2		--	72180911(-)	`AGGGAG/CACttt`	1	--	us2k¹ trp³		1	MN	184
rs76825424^1,2	C,F,	--	72180920(+)	`CTCCTA/GGAGTA`	1	--	us2k¹		1	NA	120
rs62465135^1,2	C,F,	--	72181071(+)	`CGCGTG/CGCCGG`	1	--	us2k¹		2	NA	4
rs17856756^1,2	C,F,H	--	72182751(+)	`TCAAGA/GTCGGG`	2	I V	mis¹		4	NS NA	460
rs17856757^1,2	C	--	72182980(+)	`CACCAG/ACGGCG`	2	/N /S	mis¹ ese³		2	NA	4
rs1178946^1,2	C,F,H,	--	72183367(-)	`ATTAGG/AGGAGA`	1	--	ut3¹ ese³		7	MN NS NA	938
rs113683726^1,2	C	--	72183377(+)	`TGCGGG/AGGCTG`	1	--	ut3¹		1	NA	2

HapMap Linkage Disequilibrium report for FZD9 (72848109 - 72850450 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FZD9
1 CNV: 3685
Human Gene Mutation Database (HGMD): FZD9

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FZD9 for disorders           About GeneDecksing

OMIM gene information: 601766    OMIM disorders: --

16 diseases for FZD9:    About MalaCards

williams syndrome williams-beuren syndrome exudative vitreoretinopathy vitreoretinopathy

basal cell carcinoma viral hepatitis esophageal carcinoma esophagitis

periodontitis lung cancer hepatitis carcinoma

thyroiditis neuronitis colorectal cancer glioblastoma

1 disease from the University of Copenhagen DISEASES database for FZD9:

Williams-Beuren syndrome

1 Novoseek disease relationship for FZD9 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
williams syndrome	67.1	1	10198163 (1)

Human Genome Epidemiology (HuGE) Navigator: FZD9 (2 documents)
Tumor Gene Database (TGDB): FZD9

Export disorders for FZD9 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FZD9 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with FZD9)

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A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23. (PubMed id 9147651)^{1, 2, 3, 9} Wang Y.-K....Francke U. (1997)
Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome. (PubMed id 10198163)^{1, 3, 9} Wang Y.K....Francke U. (1999)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. (PubMed id 9707618)^{1, 2} Tanaka S.... Sugimachi K. (1998)
Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells. (PubMed id 19038973)^{1, 9} Wang H.X....Kidder G.M. (2009)
Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation. (PubMed id 15705594)^{1, 9} Winn R.A....Heasley L.E. (2005)
SiRNA of frizzled-9 suppresses proliferation and moti lity of hepatoma cells. (PubMed id 19724923)^{1, 9} Fujimoto T....Yokosuka O. (2009)
Comprehensive copy number variant (CNV) analysis of n euronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)¹ Saus E....Estivill X. (2010)
Expression profile of the embryonic markers nanog, OC T-4, SSEA-1, SSEA-4, and frizzled-9 receptor in human periodontal ligament mese nchymal stem cells. (PubMed id 20458727)¹ Trubiani O....Nanci A. (2010)
Sprouty-4 inhibits transformed cell growth, migration and invasion, and epithelial-mesenchymal transition, and is regulated by Wnt7A through PPARgamma in non-small cell lung cancer. (PubMed id 20501643)¹ Tennis M.A....Winn R.A. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8326	HGNC: 4047	AceView: FZD9	Ensembl:ENSG00000188763	euGenes: HUgn8326
ECgene: FZD9	Kegg: 8326	H-InvDB: FZD9

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FZD9	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FZD9	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for FZD9 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FZD9 gene:
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frizzled family receptor 9

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