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FZD9 Gene

protein-coding   GIFtS: 70
GCID: GC07P072848

Frizzled Class Receptor 9

(Previous names: frizzled (Drosophila) homolog 9, frizzled homolog 9 (Drosophila),...)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Frizzled Class Receptor 91 2     Frizzled Homolog 92
FZD32 3 5     frizzled-92
Frizzled 9, Seven Transmembrane Spanning Receptor1 2     fz-92
Frizzled Family Receptor 91 2     fzE62
hFz92 3     Fz-93
Frizzled (Drosophila) Homolog 91     FzE63
Frizzled Homolog 9 (Drosophila)1     CD349 Antigen3
CD3492     

External Ids:    HGNC: 40471   Entrez Gene: 83262   Ensembl: ENSG000001887637   OMIM: 6017665   UniProtKB: O001443   

Export aliases for FZD9 gene to outside databases

Previous GC identifers: GC07P071488 GC07P072246 GC07P072260 GC07P072292 GC07P072486 GC07P068729


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FZD9 Gene:
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling
proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and
heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed
predominantly in brain, testis, eye, skeletal muscle, and kidney. (provided by RefSeq, Jul 2008)

GeneCards Summary for FZD9 Gene:
FZD9 (frizzled class receptor 9) is a protein-coding gene. Diseases associated with FZD9 include exudative vitreoretinopathy, and williams-beuren syndrome. GO annotations related to this gene include G-protein coupled receptor activity and protein heterodimerization activity. An important paralog of this gene is FZD3.

UniProtKB/Swiss-Prot: FZD9_HUMAN, O00144
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical
signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear
accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and
calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway
or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of
GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and
intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues

Gene Wiki entry for FZD9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the FZD9 gene promoter:
         AhR   TBP   Elk-1   PPAR-gamma1   AML1a   Nkx2-5   PPAR-gamma2   ATF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FZD9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FZD9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.23

FZD9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZD9 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P072848:  view genomic region     (about GC identifiers)

Start:
72,848,109 bp from pter      End:
72,850,450 bp from pter
Size:
2,342 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 72,181,181-72,183,522     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FZD9_HUMAN, O00144 (See protein sequence)
Recommended Name: Frizzled-9 precursor  
Size: 591 amino acids; 64466 Da
Caution: Has been first described as FZD3 in literature

Explore the universe of human proteins at neXtProt for FZD9: NX_O00144

Explore proteomics data for FZD9 at MOPED

Post-translational modifications: 

  • Ubiquitinated by ZNRF3, leading to its degradation by the proteasome (By similarity)1
  • Glycosylation2 at Asn53, Asn158
  • Modification sites at PhosphoSitePlus

  • See FZD9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003499.1  
    ENSEMBL proteins: 
     ENSP00000345785  
    Reactome Protein details: O00144

    FZD9 Human Recombinant Protein Products:

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    FZD9 Antibody Products:

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    Cloud-Clone Corp. CLIAs for FZD9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    FZD: GPCR / Class F : Frizzled receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: FZD9
    Frizzled Class GPCRs

    4 InterPro protein domains:
     IPR000539 Frizzled
     IPR020067 Frizzled_dom
     IPR015526 Frizzled/SFRP
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry O00144

    ProtoNet protein and cluster: O00144

    1 Blocks protein domain: IPB000539 Frizzled protein signature

    UniProtKB/Swiss-Prot: FZD9_HUMAN, O00144
    Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in
    the activation of the Wnt/beta-catenin signaling pathway (By similarity)
    Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
    Similarity: Belongs to the G-protein coupled receptor Fz/Smo family
    Similarity: Contains 1 FZ (frizzled) domain


    FZD9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FZD9_HUMAN, O00144
    Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical
    signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear
    accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and
    calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway
    or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of
    GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and
    intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues

         Genatlas biochemistry entry for FZD9:
    Drosophila frizzled polarity gene homolog,G protein coupled receptor superfamily,exhibiting characteristics of a
    WNT receptor,expressed in brain,testis,eye,skeletal muscle,kidney,involved in signal transduction,activating
    Dishevelled,located in the WBS1 deletion

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005515protein binding ----
    GO:0017147Wnt-protein binding IPI19038973
    GO:0030165PDZ domain binding IBA--
         
    FZD9 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FZD9:
     Decreased Salmonella enterica   Increased gamma-H2AX phosphory 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Fzd9):
     behavior/neurological  cellular  growth/size/body  hematopoietic system  immune system 
     mortality/aging  nervous system  skeleton 

    FZD9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FZD9: Fzd9tm1Sjp Fzd9tm1Lex Fzd9tm1Uta

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FZD9
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FZD9

    miRNA
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    hsa-mir-31-5p (MIRT004984), hsa-mir-98-5p (MIRT027778)

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    Selected qRT-PCR Assays for microRNAs that regulate FZD9 (see all 10):
    hsa-miR-499-3p hsa-miR-324-3p hsa-miR-1285 hsa-miR-520a-5p hsa-miR-612 hsa-miR-629 hsa-miR-525-5p hsa-miR-2115
    SwitchGear 3'UTR luciferase reporter plasmidFZD9 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FZD9_HUMAN, O00144: Cell membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA19038973
    GO:0005886plasma membrane IDA19038973
    GO:0009986cell surface IDA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    FZD9 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FZD9 About   (see all 22)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    GSK3 Signaling0.61
    4Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    Wnt Signaling Pathway and Pluripotency0.55
    5Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for FZD9
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FZD9 (see all 11)
        Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Colorectal Cancer Metastasis
    Glioblastoma Multiforme

    2 GeneGo (Thomson Reuters) Pathways for FZD9
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    4 BioSystems Pathways for FZD9
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway NetPath
    Wnt signaling network

    2 Sino Biological Pathways for FZD9
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    1 Reactome Pathway for FZD9
        Class B/2 (Secretin family receptors)


    Selected Kegg Pathways  (Kegg details for FZD9) (see all 7):
        Wnt signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection
    Pathways in cancer


    FZD9 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FZD9: 
              G Protein Coupled Receptors 384HT in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Stem Cell Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FZD9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FZD9 (O001442, 3 ENSP000003457854) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDFIQ997502, 3, ENSP000002303214MINT-66133 I2D: score=4 STRING: ENSP00000230321
    WNT1P046283, ENSP000002935494I2D: score=1 STRING: ENSP00000293549
    WNT2P095443, ENSP000002654414I2D: score=1 STRING: ENSP00000265441
    WNT7AO007553, ENSP000002850184I2D: score=1 STRING: ENSP00000285018
    GNAO1ENSP000002624934STRING: ENSP00000262493
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001944vasculature development IBA--
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007399nervous system development TAS9147651
    GO:0007405neuroblast proliferation IBA--
    GO:0007420brain development IBA--

    FZD9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FZD9

    1 HMDB Compound for FZD9    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for FZD9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 8.87 1 15705594 (1)



    FZD9 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FZD9 gene: 
    NM_003508.2  

    Unigene Cluster for FZD9:

    Frizzled family receptor 9
    Hs.647029  [show with all ESTs]
    Unigene Representative Sequence: BC026333
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000344575(uc003tyb.3)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    hsa-miR-499-3p hsa-miR-324-3p hsa-miR-1285 hsa-miR-520a-5p hsa-miR-612 hsa-miR-629 hsa-miR-525-5p hsa-miR-2115
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      QuantiTect SYBR Green Assays in human, mouse, rat FZD9
      QuantiFast Probe-based Assays in human, mouse, rat FZD9

    Additional mRNA sequence: 

    BC026333.1 U82169.1 

    1 DOTS entry:

    DT.40117792 

    15 AceView cDNA sequences:

    BQ679374 BQ006532 NM_003508 BG705632 BC026333 BQ681183 U82169 BI915516 
    BX369755 BX375411 BI757995 AW148871 BQ678465 BI918465 BI524304 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FZD9 expression in normal human tissues (normalized intensities)      FZD9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTAAGACGG
    FZD9 Expression
    About this image


    FZD9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Placenta (Extraembryonic Tissues)
             Chorionic Mesenchymal Stromal Cells Chorionic Villus
     
     Chorion (Extraembryonic Tissues)
             Chorionic Mesenchymal Stromal Cells Chorionic Villus
     
     Mesenchymal Stem Cells
             Chorionic Mesenchymal Stromal Cells Chorionic Villus
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced E15 cells
    FZD9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FZD9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.647029

    UniProtKB/Swiss-Prot: FZD9_HUMAN, O00144
    Tissue specificity: Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney.
    Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver
    and kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FZD9: 
              G Protein Coupled Receptors 384HT in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Stem Cell Signaling in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat FZD9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FZD9 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fzd91 , 5 frizzled homolog 9 (Drosophila)1, 5 87.54(n)1
    95.77(a)1
      5 (75.08 cM)5
    143711  NM_010246.11  NP_034376.11 
     1352489385 
    chicken
    (Gallus gallus)
    Aves FZD91 frizzled family receptor 9 80.3(n)
    79.73(a)
      373886  NM_001276283.1  NP_001263212.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fzd91 frizzled family receptor 9 67.67(n)
    72.82(a)
      100487936  XM_004911764.1  XP_004911821.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF169639.12   -- 79.74(n)   58023  AF169639.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fz26
    frizzled 2
    34(a)
    1 → many
    3L(19134075-19228473)


    ENSEMBL Gene Tree for FZD9 (if available)
    TreeFam Gene Tree for FZD9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FZD9 gene
    FZD32  FZD102  FZD82  FZD12  FZD52  FZD22  SFRP42  SMO2  
    FZD42  FZD62  SFRP12  FRZB2  SFRP52  FZD72  SFRP22  
    10 SIMAP similar genes for FZD9 using alignment to 2 protein entries:     FZD9_HUMAN (see all proteins):
    FZD10    GPCR    FZD4    FZD5    FZD1    FZD7
    FZD2    FZD6    FZD3    FZD8

    FZD9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FZD9 (see all 121)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1393420811,2
    --72179209(+) TGAGTA/CCTCCA 1 -- us2k10--------
    rs1441380461,2
    --72179427(+) GGCGAC/TACTCC 1 -- us2k10--------
    rs1120459781,2
    F--72179514(+) CTATGC/ACCTTG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1465098161,2
    --72179636(+) TCAGAG/TTCAGG 1 -- us2k10--------
    rs1178671181,2
    C--72179666(+) ATTTTC/TTTTTT 1 -- us2k10--------
    rs731349111,2
    --72179680(+) TTTTTC/TTTTTT 1 -- us2k10--------
    rs356042561,2
    C--72179694(+) TTTTTT/-CAGGC 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs421201,2
    C,F--72179934(-) ggtgcG/Catctt 1 -- us2k11Minor allele frequency- C:0.50NA 2
    rs1149449921,2
    F--72180092(+) CACTGC/TGCCTG 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1451969281,2
    C--72180229(+) TGGGTA/TCAAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FZD9 (72848109 - 72850450 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FZD9:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831027CNV Loss17160897
    dgv7324n71CNV Gain21882294
    nsv888362CNV Gain21882294
    dgv2099e1CNV Complex17122850
    dgv2095e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): FZD9
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FZD9
    DNA2.0 Custom Variant and Variant Library Synthesis for FZD9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601766    OMIM disorders: --

    12 diseases for FZD9:    About MalaCards
    exudative vitreoretinopathy    williams-beuren syndrome    viral hepatitis    basal cell carcinoma
    glioblastoma multiforme    periodontitis    lung cancer    colorectal cancer
    hepatitis    thyroiditis    esophagitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for FZD9:
    Williams-Beuren syndrome

    FZD9 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for FZD9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    williams syndrome 67.1 1 10198163 (1)

    Genetic Association Database (GAD): FZD9
    Human Genome Epidemiology (HuGE) Navigator: FZD9 (2 documents)
    Tumor Gene Database (TGDB): FZD9

    Export disorders for FZD9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FZD9 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with FZD9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23. (PubMed id 9147651)1, 2, 3, 9 Wang Y.-K....Francke U. (Hum. Mol. Genet. 1997)
    2. Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome. (PubMed id 10198163)1, 3, 9 Wang Y.K....Francke U. (Genomics 1999)
    3. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (J Psychiatr Res 2010)
    4. Non-association between polymorphisms of the frizzled receptor genes and bone mineral density in postmenopausal Korean women. (PubMed id 19543507)1, 4 Kim J.G....Moon S.Y. (J. Korean Med. Sci. 2009)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    6. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. (PubMed id 9707618)1, 2 Tanaka S.... Sugimachi K. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    7. Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells. (PubMed id 19038973)1, 9 Wang H.X....Kidder G.M. (Mol. Hum. Reprod. 2009)
    8. Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation. (PubMed id 15705594)1, 9 Winn R.A....Heasley L.E. (J. Biol. Chem. 2005)
    9. SiRNA of frizzled-9 suppresses proliferation and motility of hepatoma cells. (PubMed id 19724923)1, 9 Fujimoto T....Yokosuka O. (Int. J. Oncol. 2009)
    10. Expression profile of the embryonic markers nanog, OCT-4, SSEA-1, SSEA-4, and frizzled-9 receptor in human periodontal ligament mesenchymal stem cells. (PubMed id 20458727)1 Trubiani O....Nanci A. (J. Cell. Physiol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8326 HGNC: 4047 AceView: FZD9 Ensembl:ENSG00000188763 euGenes: HUgn8326
    ECgene: FZD9 Kegg: 8326 H-InvDB: FZD9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FZD9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FZD9 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FZD9 gene:
    Search GeneIP for patents involving FZD9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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