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Aliases for FZD8 Gene

Aliases for FZD8 Gene

  • Frizzled Class Receptor 8 2 3
  • Frizzled 8, Seven Transmembrane Spanning Receptor 2 3
  • Frizzled Family Receptor 8 2 3
  • FZ-8 3 4
  • HFZ8 3 4
  • Frizzled (Drosophila) Homolog 8 2
  • Frizzled Homolog 8 (Drosophila) 2
  • Frizzled Homolog 8 3

External Ids for FZD8 Gene

Previous GeneCards Identifiers for FZD8 Gene

  • GC10M035674
  • GC10M036077
  • GC10M035931
  • GC10M035967
  • GC10M035927

Summaries for FZD8 Gene

Entrez Gene Summary for FZD8 Gene

  • This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for FZD8 Gene

FZD8 (Frizzled Class Receptor 8) is a Protein Coding gene. Diseases associated with FZD8 include exudative vitreoretinopathy and cystitis. Among its related pathways are Signaling by GPCR and Downstream signaling events of B Cell Receptor (BCR). GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is FZD10.

UniProtKB/Swiss-Prot for FZD8 Gene

  • Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.

Gene Wiki entry for FZD8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FZD8 Gene

Genomics for FZD8 Gene

Regulatory Elements for FZD8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FZD8 Gene

Chromosome:
10
Start:
35,638,249 bp from pter
End:
35,642,278 bp from pter
Size:
4,030 bases
Orientation:
Minus strand

Genomic View for FZD8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for FZD8 Gene

Proteins for FZD8 Gene

  • Protein details for FZD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H461-FZD8_HUMAN
    Recommended name:
    Frizzled-8
    Protein Accession:
    Q9H461

    Protein attributes for FZD8 Gene

    Size:
    694 amino acids
    Molecular mass:
    73300 Da
    Quaternary structure:
    • Component of a Wnt-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly with LRP5 or LRP6; the interaction is promoted by Wnt-binding and signaling and inhibited by DKK1. Interacts with GPOC, RSPO1 and RSPO3 (By similarity).

neXtProt entry for FZD8 Gene

Proteomics data for FZD8 Gene at MOPED

Post-translational modifications for FZD8 Gene

  • Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
  • Glycosylation at Asn 49, Asn 152, and Asn 475
  • Modification sites at PhosphoSitePlus

Other Protein References for FZD8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FZD8 Gene

Domains & Families for FZD8 Gene

Gene Families for FZD8 Gene

Protein Domains for FZD8 Gene

Suggested Antigen Peptide Sequences for FZD8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H461

UniProtKB/Swiss-Prot:

FZD8_HUMAN :
  • The PDZ-binding motif mediates interaction with GOPC.
  • Belongs to the G-protein coupled receptor Fz/Smo family.
Domain:
  • The PDZ-binding motif mediates interaction with GOPC.
  • Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
  • The FZ domain is involved in binding with Wnt ligands.
  • Contains 1 FZ (frizzled) domain.
Family:
  • Belongs to the G-protein coupled receptor Fz/Smo family.
genes like me logo Genes that share domains with FZD8: view

Function for FZD8 Gene

Molecular function for FZD8 Gene

UniProtKB/Swiss-Prot Function:
Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.

Gene Ontology (GO) - Molecular Function for FZD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity IBA --
GO:0005102 receptor binding IEA --
GO:0005515 protein binding IPI 22682250
GO:0017147 Wnt-protein binding IBA --
genes like me logo Genes that share ontologies with FZD8: view
genes like me logo Genes that share phenotypes with FZD8: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FZD8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FZD8 Gene

Localization for FZD8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FZD8 Gene

Membrane; Multi-pass membrane protein. Golgi apparatus. Cell membrane; Multi-pass membrane protein. Note=Colocalizes with GOPC at the Golgi apparatus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FZD8 Gene COMPARTMENTS Subcellular localization image for FZD8 gene
Compartment Confidence
golgi apparatus 3
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for FZD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane TAS 11295046
genes like me logo Genes that share ontologies with FZD8: view

Pathways & Interactions for FZD8 Gene

genes like me logo Genes that share pathways with FZD8: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for FZD8 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for FZD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001525 angiogenesis IEA --
GO:0001934 positive regulation of protein phosphorylation --
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with FZD8: view

Drugs & Compounds for FZD8 Gene

(1) Drugs for FZD8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
genes like me logo Genes that share compounds with FZD8: view

Transcripts for FZD8 Gene

mRNA/cDNA for FZD8 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(65) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FZD8 Gene

Frizzled family receptor 8:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FZD8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FZD8 Gene

No ASD Table

Relevant External Links for FZD8 Gene

GeneLoc Exon Structure for
FZD8
ECgene alternative splicing isoforms for
FZD8

Expression for FZD8 Gene

mRNA expression in normal human tissues for FZD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FZD8 Gene

This gene is overexpressed in Cervix (37.2) and Lung (26.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FZD8 Gene



SOURCE GeneReport for Unigene cluster for FZD8 Gene Hs.302634

mRNA Expression by UniProt/SwissProt for FZD8 Gene

Q9H461-FZD8_HUMAN
Tissue specificity: Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney, heart, pancreas and skeletal muscle
genes like me logo Genes that share expression patterns with FZD8: view

Protein tissue co-expression partners for FZD8 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FZD8 Gene

Orthologs for FZD8 Gene

This gene was present in the common ancestor of animals.

Orthologs for FZD8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FZD8 35
  • 91.46 (n)
  • 94.42 (a)
FZD8 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FZD8 35
  • 91.96 (n)
  • 95.43 (a)
FZD8 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fzd8 35
  • 86.33 (n)
  • 93.27 (a)
Fzd8 16
Fzd8 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FZD8 35
  • 97.97 (n)
  • 97.9 (a)
FZD8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100909849 35
  • 87.26 (n)
  • 93.7 (a)
oppossum
(Monodelphis domestica)
Mammalia FZD8 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves FZD8 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FZD8 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fzd8 35
  • 78.38 (n)
  • 84.5 (a)
Str.10842 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.412 35
zebrafish
(Danio rerio)
Actinopterygii fzd8a 35
  • 77.2 (n)
  • 84.3 (a)
fzd8a 36
  • 84 (a)
OneToMany
fzd8b 36
  • 73 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta fz2 36
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cfz-2 35
  • 53.99 (n)
  • 47.17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for FZD8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FZD8 Gene

ENSEMBL:
Gene Tree for FZD8 (if available)
TreeFam:
Gene Tree for FZD8 (if available)

Paralogs for FZD8 Gene

Paralogs for FZD8 Gene

(8) SIMAP similar genes for FZD8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FZD8: view

Variants for FZD8 Gene

Sequence variations from dbSNP and Humsavar for FZD8 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1352 -- 35,638,365(+) ATGGA(C/T)CAGAA utr-variant-3-prime
rs1353 -- 35,638,417(+) AAACT(A/C)ATTTT utr-variant-3-prime
rs1355 -- 35,638,419(+) ACTCA(A/T)TTTGA utr-variant-3-prime
rs12653 -- 35,638,655(+) TACTT(A/G)TATCT utr-variant-3-prime
rs625858 -- 35,639,296(-) GGAGA(C/G)CCAAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FZD8 Gene

Variant ID Type Subtype PubMed ID
nsv825337 CNV Gain 20364138
dgv144n67 CNV Gain 20364138
nsv466871 CNV Loss 19166990
nsv521143 CNV Loss 19592680
nsv825340 CNV Gain 20364138
nsv825341 CNV Gain 20364138
esv22469 CNV Loss 19812545

Variation tolerance for FZD8 Gene

Residual Variation Intolerance Score: 6.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FZD8 Gene

HapMap Linkage Disequilibrium report
FZD8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FZD8 Gene

Disorders for FZD8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FZD8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
exudative vitreoretinopathy
  • exudative vitreoretinopathy 1
cystitis
- elite association
Search FZD8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FZD8

Genetic Association Database (GAD)
FZD8
Human Genome Epidemiology (HuGE) Navigator
FZD8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FZD8
genes like me logo Genes that share disorders with FZD8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FZD8 Gene

Publications for FZD8 Gene

  1. Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2. (PMID: 11295046) Saitoh T. … Katoh M. (Int. J. Oncol. 2001) 2 23 67
  2. Comparative genomics on Wnt8a and Wnt8b genes. (PMID: 15754011) Katoh M. … Katoh M. (Int. J. Oncol. 2005) 23 67
  3. Comparative genomics on Dkk1 orthologs. (PMID: 15942669) Katoh Y. … Katoh M. (Int. J. Oncol. 2005) 23 67
  4. Comparative genomics on Fzd8 orthologs. (PMID: 15809770) Katoh Y. … Katoh M. (Oncol. Rep. 2005) 23 67
  5. Targeting the c-Met/FZD8 signaling axis eliminates patient-derived cancer stem-like cells in head and neck squamous carcinomas. (PMID: 25320014) Sun S. … Zhang Z. (Cancer Res. 2014) 67

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