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FZD8 Gene

protein-coding   GIFtS: 64
GCID: GC10M035927

Frizzled Class Receptor 8

(Previous names: frizzled (Drosophila) homolog 8, frizzled homolog 8 (Drosophila),...)
  See FZD8-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Frizzled Class Receptor 81 2     Frizzled Homolog 82
Frizzled 8, Seven Transmembrane Spanning Receptor1 2     frizzled-82
Frizzled Family Receptor 81 2     hFZ82
Frizzled (Drosophila) Homolog 81     Fz-83
Frizzled Homolog 8 (Drosophila)1     hFz83
FZ-82     

External Ids:    HGNC: 40461   Entrez Gene: 83252   Ensembl: ENSG000001772837   OMIM: 6061465   UniProtKB: Q9H4613   

Export aliases for FZD8 gene to outside databases

Previous GC identifers: GC10M035674 GC10M036077 GC10M035931 GC10M035967


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FZD8 Gene:
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane
domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most
frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in
two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure
of the extracellular cysteine-rich domain of a similar mouse protein has been determined. (provided by RefSeq,
Jul 2008)

GeneCards Summary for FZD8 Gene:
FZD8 (frizzled class receptor 8) is a protein-coding gene. Diseases associated with FZD8 include exudative vitreoretinopathy. GO annotations related to this gene include G-protein coupled receptor activity and ubiquitin protein ligase binding. An important paralog of this gene is FZD3.

UniProtKB/Swiss-Prot: FZD8_HUMAN, Q9H461
Function: Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin
signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The
beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3
kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway
involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents
a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for
Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be
involved in transduction and intercellular transmission of polarity information during tissue morphogenesis
and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1

Gene Wiki entry for FZD8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_008705.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the FZD8 gene promoter:
         TBP   GR   ER-alpha   IRF-1   C/EBPalpha   CHOP-10   AREB6   E2F   E2F-1   GR-alpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FZD8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FZD8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p11.21   Ensembl cytogenetic band:  10p11.21   HGNC cytogenetic band: 10p11.2

FZD8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZD8 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M035927:  view genomic region     (about GC identifiers)

Start:
35,927,177 bp from pter      End:
35,930,362 bp from pter
Size:
3,186 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FZD8_HUMAN, Q9H461 (See protein sequence)
Recommended Name: Frizzled-8 precursor  
Size: 694 amino acids; 73300 Da
Subunit: Component of a Wnt-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6.
Interacts directly with LRP5 or LRP6; the interaction is promoted by Wnt-binding and signaling and inhibited by
DKK1. Interacts with GPOC, RSPO1 and RSPO3 (By similarity)

Explore the universe of human proteins at neXtProt for FZD8: NX_Q9H461

Explore proteomics data for FZD8 at MOPED

Post-translational modifications: 

  • Ubiquitinated by ZNRF3, leading to its degradation by the proteasome1
  • Glycosylation2 at Asn49, Asn152, Asn475

  • See FZD8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_114072.1  
    ENSEMBL proteins: 
     ENSP00000363826  
    Reactome Protein details: Q9H461

    FZD8 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FZD8

     
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    Cloud-Clone Corp. ELISAs for FZD8
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    Search eBioscience for ELISAs for FZD8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FZD: GPCR / Class F : Frizzled receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: FZD8
    Frizzled Class GPCRs

    5 InterPro protein domains:
     IPR000539 Frizzled
     IPR020067 Frizzled_dom
     IPR015526 Frizzled/SFRP
     IPR017981 GPCR_2-like
     IPR026547 FZD5/FZD8

    Graphical View of Domain Structure for InterPro Entry Q9H461

    ProtoNet protein and cluster: Q9H461

    1 Blocks protein domain: IPB000539 Frizzled protein signature

    UniProtKB/Swiss-Prot: FZD8_HUMAN, Q9H461
    Domain: The PDZ-binding motif mediates interaction with GOPC (By similarity)
    Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in
    the activation of the Wnt/beta-catenin signaling pathway (By similarity)
    Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
    Similarity: Belongs to the G-protein coupled receptor Fz/Smo family
    Similarity: Contains 1 FZ (frizzled) domain


    Find genes that share domains with FZD8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FZD8_HUMAN, Q9H461
    Function: Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin
    signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The
    beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3
    kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway
    involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents
    a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for
    Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be
    involved in transduction and intercellular transmission of polarity information during tissue morphogenesis
    and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005102receptor binding IEA--
    GO:0005515protein binding IPI--
    GO:0017147Wnt-protein binding IBA--
         
    Find genes that share ontologies with FZD8           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for FZD8:
     Decreased G3BP1 protein expres  Synthetic lethal with Ras  Synthetic lethal with imatinib 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fzd8):
     mortality/aging  normal  renal/urinary system 

    Find genes that share phenotypes with FZD8           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FZD8
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FZD8
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    miRNA
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    miRTarBase miRNAs that target FZD8:
    hsa-let-7c-5p (MIRT051873), hsa-mir-374b-5p (MIRT016029), hsa-mir-335-5p (MIRT018441), hsa-mir-375 (MIRT007255)

    Block miRNA regulation of human, mouse, rat FZD8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FZD8 (see all 34):
    hsa-miR-374a* hsa-miR-124 hsa-miR-208a hsa-miR-208b hsa-miR-3613-3p hsa-miR-3116 hsa-miR-2116 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidFZD8 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FZD8

    Gene Editing
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    PureStem 7SMOO32, NCr-fac & Meso Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FZD8_HUMAN, Q9H461: Membrane; Multi-pass membrane protein. Golgi apparatus (By similarity). Cell membrane;
    Multi-pass membrane protein (By similarity). Note=Colocalizes with GOPC at the Golgi apparatus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    golgi apparatus2
    extracellular1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005794Golgi apparatus IEA--
    GO:0005886plasma membrane IBA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane TAS11295046

    Find genes that share ontologies with FZD8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FZD8 About   (see all 23)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    3beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Signaling by Wnt0.79
    4CDK-mediated phosphorylation and removal of Cdc6
    Asymmetric localization of PCP proteins0.75
    PCP/CE pathway0.70
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    GSK3 Signaling0.61


    Find genes that share SuperPaths with FZD8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for FZD8
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FZD8 (see all 11)
        Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Colorectal Cancer Metastasis
    Glioblastoma Multiforme

    2 GeneGo (Thomson Reuters) Pathways for FZD8
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    4 BioSystems Pathways for FZD8
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway NetPath
    Wnt signaling network

    2 Reactome Pathways for FZD8
        regulation of FZD by ubiquitination
    Class B/2 (Secretin family receptors)


    Selected Kegg Pathways  (Kegg details for FZD8) (see all 7):
        Wnt signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection
    Pathways in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FZD8: 
              G Protein Coupled Receptors 384HT in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FZD8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FZD8 (Q9H4611, 3 ENSP000003638264) via UniProtKB, MINT, STRING, and/or I2D (see all 90)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WNT1P046283, ENSP000002935494I2D: score=4 STRING: ENSP00000293549
    GOPCQ9HD263, ENSP000003574844I2D: score=3 STRING: ENSP00000357484
    RYKP349253, ENSP000002960844I2D: score=2 STRING: ENSP00000296084
    LRP6O755813, ENSP000002613494I2D: score=2 STRING: ENSP00000261349
    WNT3AP567041, ENSP000002845234EBI-6254212,EBI-6173037 STRING: ENSP00000284523
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001934positive regulation of protein phosphorylation ----
    GO:0001944vasculature development IBA--
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007409axonogenesis IBA--

    Find genes that share ontologies with FZD8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FZD8

    1 HMDB Compound for FZD8    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FZD8 gene: 
    NM_031866.2  

    Unigene Cluster for FZD8:

    Frizzled family receptor 8
    Hs.302634  [show with all ESTs]
    Unigene Representative Sequence: AB043703
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000374694(uc001iyz.1)
    miRNA
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    hsa-miR-374a* hsa-miR-124 hsa-miR-208a hsa-miR-208b hsa-miR-3613-3p hsa-miR-3116 hsa-miR-2116 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidFZD8 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: FZD8 (NM_031866)
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      QuantiTect SYBR Green Assays in human, mouse, rat FZD8
      QuantiFast Probe-based Assays in human, mouse, rat FZD8

    Additional mRNA sequence: 

    AB043703.1 AF086500.1 

    3 DOTS entries:

    DT.442014  DT.101971707  DT.95159292 

    Selected AceView cDNA sequences (see all 65):

    AA932694 BM311739 CR590011 BX362768 AI371287 AA854237 AI091277 AA457138 
    NM_031866 AW340311 R73422 BQ447397 BM684711 BM992192 BF593951 AI742241 
    AW340210 BM311149 AA923048 AI688787 AA535702 AF086500 BQ185731 AI337991 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FZD8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAATGAACT
    FZD8 Expression
    About this image


    FZD8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
             Floor plate-like cells
     
     Hypoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Anterior Visceral Endoderm Cells Extraembryonic Visceral Endoderm
     
     Yolk Sac (Extraembryonic Tissues)    fully expand to see all 2 entries
             Anterior Visceral Endoderm Cells Extraembryonic Visceral Endoderm
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
    FZD8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FZD8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.302634

    UniProtKB/Swiss-Prot: FZD8_HUMAN, Q9H461
    Tissue specificity: Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in
    kidney, heart, pancreas and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FZD8: 
              G Protein Coupled Receptors 384HT in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for FZD8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FZD8
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    QuantiFast Probe-based Assays in human, mouse, rat FZD8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FZD8 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fzd81 , 5 frizzled homolog 8 (Drosophila)1, 5 86.33(n)1
    93.27(a)1
      18 (4.91 cM)5
    143701  NM_008058.21  NP_032084.21 
     92128565 
    chicken
    (Gallus gallus)
    Aves FZD86
    frizzled family receptor 8
    94(a)
    1 ↔ 1
    2(12761773-12762399)
    lizard
    (Anolis carolinensis)
    Reptilia FZD86
    frizzled family receptor 8
    82(a)
    1 ↔ 1
    6(10678703-10680740)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.4122 Xenopus laevis frizzled-8 (xfz8) mRNA, complete cds 84.11(n)    AF033110.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fzd8a2 frizzled homolog 8a 81.47(n)   58073  AF060697.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fz26
    frizzled 2
    48(a)
    1 → many
    3L(19134075-19228473)
    worm
    (Caenorhabditis elegans)
    Secernentea cfz-21 cfz-2 53.99(n)
    47.17(a)
      178768  NM_071564.5  NP_503965.2 


    ENSEMBL Gene Tree for FZD8 (if available)
    TreeFam Gene Tree for FZD8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FZD8 gene
    FZD32  FZD102  FZD12  FZD52  FZD22  FZD92  SFRP42  SMO2  
    FZD42  FZD62  SFRP12  FRZB2  SFRP52  FZD72  SFRP22  
    8 SIMAP similar genes for FZD8 using alignment to 1 protein entry:     FZD8_HUMAN:
    FZD5    FZD2    FZD1    FZD7    FZD10    FZD9
    FZD4    GPCR

    Find genes that share paralogs with FZD8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FZD8 (see all 85)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs792411441,2
    C--35926690(+) TAAGAG/AGAGAT 1 -- ds50011Minor allele frequency- A:0.01EA 120
    rs1930239201,2
    --35926697(+) AGATAA/GGCAGC 1 -- ds50010--------
    rs1858570501,2
    --35926775(+) AAAGAA/CCAAGT 1 -- ds50010--------
    rs749417811,2
    C,F--35926871(+) ATTGCC/TGAAGC 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1898944721,2
    --35926918(+) AATTAG/TCTTAG 1 -- ds50010--------
    rs567556691,2
    C,F--35927042(+) TGCTCC/TCCTAC 1 -- ds50013Minor allele frequency- T:0.09WA EA 240
    rs1453902231,2
    --35927059(+) GTCAAC/GTGACT 1 -- ds50010--------
    rs118138641,2
    C,H--35927167(+) CTCCAG/TAAATG 1 -- ds50012Minor allele frequency- T:0.00NA 4
    rs1410582871,2
    --35927175(+) ATGAAC/TGCAGG 1 -- ds50010--------
    rs13521,2
    C,F,H--35927293(+) ATGGAT/CCAGAA 1 -- ut31 ese310Minor allele frequency- C:0.02MN NS EA NA 1486

    HapMap Linkage Disequilibrium report for FZD8 (35927177 - 35930362 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FZD8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv22469CNV Loss19812545
    nsv466871CNV Loss19166990
    nsv521143CNV Loss19592680
    nsv825341CNV Gain20364138
    dgv144n67CNV Gain20364138
    nsv825337CNV Gain20364138
    nsv825340CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FZD8
    DNA2.0 Custom Variant and Variant Library Synthesis for FZD8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606146    OMIM disorders: --

    1 disease for FZD8:    
    About MalaCards
    exudative vitreoretinopathy

    1 disease from the University of Copenhagen DISEASES database for FZD8:
    Interstitial cystitis

    Find genes that share disorders with FZD8           About GenesLikeMe

    Genetic Association Database (GAD): FZD8
    Human Genome Epidemiology (HuGE) Navigator: FZD8 (1 document)

    Export disorders for FZD8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FZD8 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with FZD8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2. (PubMed id 11295046)1, 2, 3, 9 Saitoh T.... Katoh M. (Int. J. Oncol. 2001)
    2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    3. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PubMed id 18464913)1, 4 Melzer D....Ferrucci L. (PLoS Genet. 2008)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    5. Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. (PubMed id 11448771)1, 2 Semenov M.V.... He X. (Curr. Biol. 2001)
    6. c-Jun is involved in interstitial cystitis antiproliferative factor (APF)-induced growth inhibition of human bladder cancer T24 cells. (PubMed id 21872498)1 Li Z....Kong C. (Urol. Oncol. 2013)
    7. Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer. (PubMed id 23815780)1 Bravo D.T....You L. (BMC Cancer 2013)
    8. Integration analysis of quantitative proteomics and transcriptomics data identifies potential targets of frizzled-8 protein-related antiproliferative factor in vivo. (PubMed id 22738385)1 Yang W....Kim J. (BJU Int. 2012)
    9. Genome-wide association study of periodontal pathogen colonization. (PubMed id 22699663)1 Divaris K....Offenbacher S. (J. Dent. Res. 2012)
    10. ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. (PubMed id 22575959)2 Hao H.X....Cong F. (Nature 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8325 HGNC: 4046 AceView: FZD8 Ensembl:ENSG00000177283 euGenes: HUgn8325
    ECgene: FZD8 Kegg: 8325 H-InvDB: FZD8

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FZD8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FZD8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FZD8 gene:
    Search GeneIP for patents involving FZD8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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