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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FZD8 Gene

protein-coding   GIFtS: 64
GCID: GC10M035927

frizzled family receptor 8

(Previous names: frizzled (Drosophila) homolog 8, frizzled homolog 8 (Drosophila),...)
 Explore 8 diseases affiliated with
FZD8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FZD8    

Aliases
for FZD8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Frizzled Family Receptor 81 2     Frizzled Homolog 82
Frizzled 8, Seven Transmembrane Spanning Receptor1 2     Frizzled-81
Frizzled (Drosophila) Homolog 81     HFZ81
Frizzled Homolog 8 (Drosophila)1     Fz-83
FZ-82     HFz81

External Ids:    HGNC: 40461   Entrez Gene: 83252   Ensembl: ENSG000001772837   OMIM: 6061465   UniProtKB: Q9H4613   

Export aliases for FZD8 gene to outside databases

Previous GC identifers: GC10M035674 GC10M036077 GC10M035931 GC10M035967


Summaries
for FZD8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FZD8:
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain
proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled
receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human
cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the
extracellular cysteine-rich domain of a similar mouse protein has been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FZD8_HUMAN, Q9H461
Function: Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling
through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical
signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of
beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been
seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated
in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways
seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of
polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt
proteins, such as WNT1

Gene Wiki entry for FZD8


Genomic Views
for FZD8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FZD8 gene promoter:
         TBP   GR   ER-alpha   IRF-1   C/EBPalpha   CHOP-10   AREB6   E2F   E2F-1   GR-alpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FZD8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FZD8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p11.21   Ensembl cytogenetic band:  10p11.21   HGNC cytogenetic band: 10p11.2

FZD8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZD8 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M035927:  view genomic region     (about GC identifiers)

Start:
 35,927,177 bp from pter      End:
 35,930,362 bp from pter
Size:
 3,186 bases      Orientation:
 minus strand

Proteins
for FZD8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FZD8_HUMAN, Q9H461 (See protein sequence)
Recommended Name: Frizzled-8 precursor  
Size: 694 amino acids; 73300 Da
Subunit: Component of a Wnt-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts
directly with LRP5 or LRP6; the interaction is promoted by Wnt-binding and signaling and inhibited by DKK1. Interacts
with GPOC, RSPO1 and RSPO3 (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein. Golgi apparatus (By similarity). Cell membrane; Multi-pass
membrane protein (By similarity). Note=Colocalizes with GOPC at the Golgi apparatus (By similarity)

Explore the universe of human proteins at neXtProt for FZD8: NX_Q9H461

Post-translational modifications:

  • Ubiquitinated by ZNRF3, leading to its degradation by the proteasome1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H461

    • FZD8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_114072.1  
    ENSEMBL proteins: 
     ENSP00000363826  
    Reactome Protein details: Q9H461
    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FZD8

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005794Golgi apparatus IEA--
    GO:0005886plasma membrane IBA--
    GO:0016021integral to membrane TAS11295046
    GO:0042995cell projection IBA--


    FZD8 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for FZD8

    Protein Domains /
    Families
    for FZD8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FZD8 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000539 Frizzled
     IPR020067 Frizzled_dom
     IPR015526 Frizzled/SFRP
     IPR017981 GPCR_2-like
     IPR026545 FZD8

    Graphical View of Domain Structure for InterPro Entry Q9H461

    ProtoNet protein and cluster: Q9H461

    1 Blocks protein family: IPB000539 Frizzled protein signature

    UniProtKB/Swiss-Prot: FZD8_HUMAN, Q9H461
    Domain: The PDZ-binding motif mediates interaction with GOPC (By similarity)
    Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the
    activation of the Wnt/beta-catenin signaling pathway (By similarity)
    Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
    Similarity: Belongs to the G-protein coupled receptor Fz/Smo family
    Similarity: Contains 1 FZ (frizzled) domain


    Function
    for FZD8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FZD8_HUMAN, Q9H461
    Function: Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling
    through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical
    signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of
    beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been
    seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated
    in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways
    seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of
    polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt
    proteins, such as WNT1

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FZD8
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate FZD8 (see all 34):
    hsa-miR-374a* hsa-miR-124 hsa-miR-208a hsa-miR-208b hsa-miR-3613-3p hsa-miR-3116 hsa-miR-2116 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmid: FZD8 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FZD8 (see all 7)
    OriGene shRNA RFP: FZD8
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    Gene Editing
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    Clone
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    Cell Line
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    LifeMap BioReagents: cell line associated with FZD8: PureStem 7SMOO32, NCr-fac & Meso Progenitor

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD8

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005102receptor binding IEA--
    GO:0005515protein binding IPI--
    GO:0017147Wnt-protein binding IBA--
    GO:0030165PDZ domain binding IPI18256285


    FZD8 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for FZD8:
     Decreased G3BP1 protein expres  Synthetic lethal with Ras  Synthetic lethal with imatinib 

    Animal Models:
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fzd8):
     mortality/aging  normal  renal/urinary system 

    FZD8 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FZD8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt Signaling Pathway
    		Wnt Signaling Pathway1.00
    		Wnt signaling pathway0.30
    		Wnt Signaling Pathway and Pluripotency0.55
    		Wnt Signaling Pathway NetPath0.22
    		Wnt Signaling Pathway0.33
    2Translation_Non-genomic (rapid) action of Androgen Receptor
    		Translation_Non-genomic (rapid) action of Androgen Receptor1.00
    		Translation Non-genomic (rapid) action of Androgen Receptor0.99
    3Transcription_Androgen Receptor nuclear signaling
    		Transcription_Androgen Receptor nuclear signaling1.00
    		Transcription Androgen Receptor nuclear signaling0.99
    4Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		GSK3 Signaling0.61
    5Human Embryonic Stem Cell Pluripotency
    		Human Embryonic Stem Cell Pluripotency1.00
    		Factors Promoting Cardiogenesis in Vertebrates0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for FZD8
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 R&D Systems Pathway for FZD8
        Wnt Signaling Pathway

    5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FZD8 (see all 11)
        Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Colorectal Cancer Metastasis
    Glioblastoma Multiforme

    2 GeneGo (Thomson Reuters) Pathways for FZD8
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    4 BioSystems Pathways for FZD8 
        Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway
    Wnt Signaling Pathway NetPath
    Wnt signaling network

    4        Reactome Pathways for FZD8
        Signal Transduction
    Signaling by GPCR
    GPCR ligand binding
    Class B/2 (Secretin family receptors)


    4         Kegg Pathways  (Kegg details for FZD8):
        Wnt signaling pathway
    Melanogenesis
    Pathways in cancer
    Basal cell carcinoma


    FZD8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FZD8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/46 Interacting proteins for FZD8 (Q9H4611, 3 ENSP000003638264) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WNT1P046283, ENSP000002935494I2D: score=4 STRING: ENSP00000293549
    GOPCQ9HD263, ENSP000003574844I2D: score=3 STRING: ENSP00000357484
    RYKP349253, ENSP000002960844I2D: score=2 STRING: ENSP00000296084
    LRP6O755813, ENSP000002613494I2D: score=2 STRING: ENSP00000261349
    WNT3AP567041, ENSP000002845234EBI-6254212,EBI-6173037 STRING: ENSP00000284523
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001934positive regulation of protein phosphorylation ----
    GO:0001944vasculature development IBA--
    GO:0007409axonogenesis IBA--
    GO:0007420brain development IBA--


    FZD8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FZD8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FZD8

    1 HMDB Compound for FZD8    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about FZD8 

    Transcripts
    for FZD8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FZD8 gene: 
    NM_031866.2  

    Unigene Cluster for FZD8:

    Frizzled family receptor 8
    Hs.302634  [show with all ESTs]
    Unigene Representative Sequence: AB043703
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000374694(uc001iyz.1)

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    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate FZD8 (see all 34):
    hsa-miR-374a* hsa-miR-124 hsa-miR-208a hsa-miR-208b hsa-miR-3613-3p hsa-miR-3116 hsa-miR-2116 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmid: FZD8 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FZD8
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    Additional cDNA sequence: 

    AB043703.1 AF086500.1 

    3 DOTS entries:

    DT.442014  DT.101971707  DT.95159292 

    24/65 AceView cDNA sequences (see all 65):

    BM311739 AA932694 CR590011 BX362768 BM992192 BQ001195 AB043703 AA535702 
    BM311149 AI371287 AI672746 BQ447397 AI221851 CA843045 BV188028 AI222347 
    BQ185731 AI091277 AF086500 AI337991 BG254236 AI688787 AI742241 AA457138 

    GeneLoc Exon Structure


    Expression
    for FZD8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FZD8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATAATGAACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FZD8 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HypoblastExtraembryonic Visceral EndodermDistal Visceral Endoderm CellsExtraembryonic Tissues, Yolk Sac
    CartilageLumbar Intervertebral DiscCartilage
    KidneyUreteric BudKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    N2/LSB/S/F8-induced cells (Generation of midbra...)
    Definitive endoderm-like cells (Generation of mesend...)
    Mesendoderm-like cells (Generation of mesend...)
    Definitive endoderm-like cells (A scalable, suspensi...)

    See FZD8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FZD8

    SOURCE GeneReport for Unigene cluster: Hs.302634

    UniProtKB/Swiss-Prot: FZD8_HUMAN, Q9H461
    Tissue specificity: Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney,
    heart, pancreas and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including FZD8: 
              G Protein Coupled Receptors 384HT in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FZD8
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD8

    Orthologs
    for FZD8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FZD8 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia FZD86
    		 --
    		 79(a)
    		 1 ↔ 1
    		 6(10678703-10680740)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.4122 Xenopus laevis frizzled-8 (xfz8) mRNA, complete cds 84.11(n)    AF033110.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii fzd8a2 frizzled homolog 8a 81.47(n)   58073  AF060697.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta fz26
    fz46
    		 frizzled 4
    		 47(a)
    19(a)
    		 1 ↔ many
    possible ortholog
    		 3L(19134075-19228473)
    X(7000305-7004325)
    worm
    (Caenorhabditis elegans)    		 Secernentea cfz-21 Protein CFZ-2 50.98(n)
    44.8(a)    		   178768  NM_071564.4  NP_503965.2 


    ENSEMBL Gene Tree for FZD8 (if available)
    TreeFam Gene Tree for FZD8 (if available) 

    Paralogs
    for FZD8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FZD8 gene
    FZD102  FZD32  FZD12  FZD52  FZD22  FZD92  SFRP42  SMO2  
    FZD42  FZD62  SFRP12  FRZB2  FZD72  SFRP52  SFRP22  
    9 SIMAP similar genes for FZD8 using alignment to 1 protein entry:     FZD8_HUMAN:
    FZD5    FZD2    FZD1    FZD7    FZD10    FZD9
    FZD4    GPCR    FZD3

    FZD8 for paralogs           About GeneDecksing



    Genomic Variants
    for FZD8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/94 NCBI SNPs in FZD8 are shown (see all 94)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs792411441,2
    		C,--35926690(+) TAAGAG/AGAGAT 1 -- ds50011Minor allele frequency- A:0.01EA 120
    rs1930239201,2
    		--35926697(+) AGATAA/GGCAGC 1 -- ds50010--------
    rs1858570501,2
    		--35926775(+) AAAGAA/CCAAGT 1 -- ds50010--------
    rs749417811,2
    		C,F,--35926871(+) ATTGCC/TGAAGC 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1898944721,2
    		--35926918(+) AATTAG/TCTTAG 1 -- ds50010--------
    rs567556691,2
    		C,--35927042(+) TGCTCC/TCCTAC 1 -- ds50013Minor allele frequency- T:0.09WA EA 240
    rs1453902231,2
    		--35927059(+) GTCAAC/GTGACT 1 -- ds50010--------
    rs118138641,2
    		C,H--35927167(+) CTCCAG/TAAATG 1 -- ds50012Minor allele frequency- T:0.00NA 4
    rs1410582871,2
    		--35927175(+) ATGAAC/TGCAGG 1 -- ds50010--------
    rs13521,2
    		C,F,H,--35927293(+) ATGGAT/CCAGAA 1 -- ut31 ese310Minor allele frequency- C:0.02MN NS EA NA 1486

    HapMap Linkage Disequilibrium report for FZD8 (35927177 - 35930362 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for FZD8
         1 CNV: 70953

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    Disorders / Diseases
    for FZD8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FZD8 for disorders           About GeneDecksing

    OMIM gene information: 606146    OMIM disorders: --

    8 diseases for FZD8:    About MalaCards
    exudative vitreoretinopathy    cystitis    vitreoretinopathy    basal cell carcinoma
    carcinoma    neuronitis    colorectal cancer    glioblastoma

    2 diseases from the University of Copenhagen DISEASES database for FZD8:
    Interstitial cystitis     Chronic interstitial cystitis
    Human Genome Epidemiology (HuGE) Navigator: FZD8 (1 document)

    Export disorders for FZD8 gene to outside databases

    Publications
    for FZD8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FZD8 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with FZD8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2. (PubMed id 11295046)1, 2, 3, 9 Saitoh T.... Katoh M. (2001)
    2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    3. Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. (PubMed id 11448771)1, 2 Semenov M.V....He X. (2001)
    4. Integration analysis of quantitative proteomics and tr anscriptomics data identifies potential targets of frizzled-8 protein-related an tiproliferative factor in vivo. (PubMed id 22738385)1 Yang W....Kim J. (2012)
    5. ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. (PubMed id 22575959)2 Hao H.X....Cong F. (2012)
    6. Genetically distinct subsets within ANCA-associated va sculitis. (PubMed id 22808956)1 Lyons P.A....Smith K.G. (2012)
    7. Inhibition of Wnt/b-catenin signaling by a soluble col lagen-derived frizzled domain interacting with Wnt3a and the receptors frizzled 1 and 8. (PubMed id 22303445)1 Hendaoui I....Musso O. (2012)
    8. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1 Jugessur A....Murray J.C. (2010)
    9. Reconstitution of a frizzled8.Wnt3a.LRP6 signaling co mplex reveals multiple Wnt and Dkk1 binding sites on LRP6. (PubMed id 20093360)1 Bourhis E....Hannoush R.N. (2010)
    10. Molecular model of the Wnt protein binding site on the surface of dimeric CRD domain of the hFzd8 receptor. (PubMed id 18505162)1 Voronkov A.E....Zefirov N.S. (2008)

    External Searches for FZD8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FZD8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8325 HGNC: 4046 AceView: FZD8 Ensembl:ENSG00000177283 euGenes: HUgn8325
    ECgene: FZD8 Kegg: 8325 H-InvDB: FZD8

    Other Databases showing FZD8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FZD8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FZD8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FZD8 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for FZD8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FZD8 gene:
    Search GeneIP for patents involving FZD8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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