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FZD7 Gene

protein-coding   GIFtS: 69
GCID: GC02P202863

Frizzled Class Receptor 7

(Previous names: frizzled (Drosophila) homolog 7, frizzled homolog 7 (Drosophila),...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Frizzled Class Receptor 71 2     Frizzled Homolog 7 (Drosophila)1
Frizzled 7, Seven Transmembrane Spanning Receptor1 2     Frizzled Homolog 72
Frizzled Family Receptor 71 2     Frizzled, Drosophila, Homolog Of, 72
FzE32 3     frizzled-72
hFz72 3     fz-72
Frizzled (Drosophila) Homolog 71     Fz-73

External Ids:    HGNC: 40451   Entrez Gene: 83242   Ensembl: ENSG000001557607   OMIM: 6034105   UniProtKB: O750843   

Export aliases for FZD7 gene to outside databases

Previous GC identifers: GC02P201116 GC02P201623 GC02P203101 GC02P202724 GC02P202607 GC02P194748


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FZD7 Gene:
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling
proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the
cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular
C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance
beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. (provided by RefSeq, Jul
2008)

GeneCards Summary for FZD7 Gene:
FZD7 (frizzled class receptor 7) is a protein-coding gene. Diseases associated with FZD7 include exudative vitreoretinopathy, and skeletal muscle regeneration. GO annotations related to this gene include Wnt-protein binding and G-protein coupled receptor activity. An important paralog of this gene is FZD3.

UniProtKB/Swiss-Prot: FZD7_HUMAN, O75084
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical
signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear
accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and
calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway
or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of
GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and
intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues

Gene Wiki entry for FZD7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the FZD7 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   LCR-F1   NF-kappaB   E2F   E2F-1   Chx10   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFZD7 promoter sequence
   Search Chromatin IP Primers for FZD7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FZD7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33

FZD7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZD7 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P202863:  view genomic region     (about GC identifiers)

Start:
202,899,310 bp from pter      End:
202,903,160 bp from pter
Size:
3,851 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FZD7_HUMAN, O75084 (See protein sequence)
Recommended Name: Frizzled-7 precursor  
Size: 574 amino acids; 63620 Da
Subunit: Interacts with MAGI3 and DVL1 (By similarity)
Secondary accessions: O94816 Q53S59 Q96B74

Explore the universe of human proteins at neXtProt for FZD7: NX_O75084

Explore proteomics data for FZD7 at MOPED

Post-translational modifications: 

  • Ubiquitinated by ZNRF3, leading to its degradation by the proteasome (By similarity)1
  • Glycosylation2 at Ser42, Asn63, Asn164
  • Modification sites at PhosphoSitePlus

  • See FZD7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003498.1  
    ENSEMBL proteins: 
     ENSP00000286201  
    Reactome Protein details: O75084

    FZD7 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FZD: GPCR / Class F : Frizzled receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: FZD7
    Frizzled Class GPCRs

    5 InterPro protein domains:
     IPR000539 Frizzled
     IPR020067 Frizzled_dom
     IPR026552 FZD7
     IPR015526 Frizzled/SFRP
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry O75084

    ProtoNet protein and cluster: O75084

    1 Blocks protein domain: IPB000539 Frizzled protein signature

    UniProtKB/Swiss-Prot: FZD7_HUMAN, O75084
    Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in
    the activation of the Wnt/beta-catenin signaling pathway (By similarity)
    Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
    Similarity: Belongs to the G-protein coupled receptor Fz/Smo family
    Similarity: Contains 1 FZ (frizzled) domain


    FZD7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FZD7_HUMAN, O75084
    Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical
    signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear
    accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and
    calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway
    or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of
    GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and
    intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues

         Genatlas biochemistry entry for FZD7:
    Drosophila frizzled polarity gene homolog,G protein coupled receptor superfamily,exhibiting characteristics of a
    WNT receptor,expressed in fetal kidney and adult skeletal muscle,heart,brain and placenta

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005109frizzled binding IPI19188438
    GO:0005515protein binding IPI18256285
    GO:0017147Wnt-protein binding IPI18313787
         
    FZD7 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for FZD7:
     Decreased substrate adherent c  Increased G2M DNA content  Increased cell death HMECs cel  Increased number of mitotic ce 

         10 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fzd7):
     cardiovascular system  craniofacial  digestive/alimentary  embryogenesis  growth/size/body 
     integument  limbs/digits/tail  mortality/aging  nervous system  pigmentation 

    FZD7 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FZD7
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    miRNA
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    hsa-mir-940 (MIRT036603), hsa-mir-192-5p (MIRT026887), hsa-mir-215-5p (MIRT024428), hsa-mir-145-5p (MIRT005690)

    Block miRNA regulation of human, mouse, rat FZD7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FZD7 (see all 70):
    hsa-miR-548j hsa-miR-607 hsa-miR-106a hsa-miR-128 hsa-miR-138-2* hsa-miR-877* hsa-miR-1273d hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidFZD7 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FZD7_HUMAN, O75084: Membrane; Multi-pass membrane protein (By similarity). Cell membrane; Multi-pass membrane
    protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytoskeleton1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane TAS9707618
    GO:0032589neuron projection membrane IBA--

    FZD7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FZD7 About   (see all 25)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    3beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Signaling by Wnt0.79
    4CDK-mediated phosphorylation and removal of Cdc6
    Asymmetric localization of PCP proteins0.75
    PCP/CE pathway0.70
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    GSK3 Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for FZD7
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FZD7 (see all 11)
        Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Colorectal Cancer Metastasis
    Glioblastoma Multiforme

    2 GeneGo (Thomson Reuters) Pathways for FZD7
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    Selected BioSystems Pathways for FZD7 (see all 6)
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway NetPath
    Wnt signaling network
    Syndecan-4-mediated signaling events

    2 Reactome Pathways for FZD7
        PCP/CE pathway
    Class B/2 (Secretin family receptors)


    Selected Kegg Pathways  (Kegg details for FZD7) (see all 7):
        Wnt signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection
    Pathways in cancer


    FZD7 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FZD7 (see all 7): 
              G Protein Coupled Receptors 384HT in human mouse rat
              WNT Signaling Targets in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat
              Liver Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FZD7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FZD7 (O750841, 2, 3 ENSP000002862014) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN1Q9UMX02, 3, ENSP000003655764MINT-66943 I2D: score=5 STRING: ENSP00000365576
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2864936 I2D: score=3 STRING: ENSP00000357292
    DLG1Q129593, ENSP000003457314I2D: score=2 STRING: ENSP00000345731
    MAGI3Q5TCQ93, ENSP000003046044I2D: score=1 STRING: ENSP00000304604
    WNT3P567033, ENSP000002255124I2D: score=1 STRING: ENSP00000225512
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001944vasculature development IBA--
    GO:0006355regulation of transcription, DNA-templated IMP18681827
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007199G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger IBA--
    GO:0007223Wnt signaling pathway, calcium modulating pathway IBA--

    FZD7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FZD7

    1 HMDB Compound for FZD7    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for FZD7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 37.1 3 15870913 (2)



    FZD7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FZD7 gene: 
    NM_003507.1  

    Unigene Cluster for FZD7:

    Frizzled family receptor 7
    Hs.173859  [show with all ESTs]
    Unigene Representative Sequence: AB017365
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000286201(uc002uyw.1)
    miRNA
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    hsa-miR-548j hsa-miR-607 hsa-miR-106a hsa-miR-128 hsa-miR-138-2* hsa-miR-877* hsa-miR-1273d hsa-miR-93
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      QuantiFast Probe-based Assays in human, mouse, rat FZD7

    Additional mRNA sequence: 

    AB010881.1 AB017365.1 AL110146.1 BC015915.1 

    1 DOTS entry:

    DT.445208 

    Selected AceView cDNA sequences (see all 124):

    BM978276 AI129705 BU931818 NM_003507 BU848687 BM920763 AI189384 CB158179 
    CA425516 AI074303 AA938994 BI767816 AW072200 W52682 AB017365 W00697 
    AI085162 AI002187 AW337763 BM992571 BQ021995 AA612575 N69049 BQ181891 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FZD7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAGATCAC
    FZD7 Expression
    About this image


    FZD7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Thalamus
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Kidney (Urinary System)
             Metanephros
    FZD7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FZD7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.173859

    UniProtKB/Swiss-Prot: FZD7_HUMAN, O75084
    Tissue specificity: High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult
    heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FZD7 (see all 7): 
              G Protein Coupled Receptors 384HT in human mouse rat
              WNT Signaling Targets in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat
              Liver Cancer in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FZD7 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fzd71 , 5 frizzled homolog 7 (Drosophila)1, 5 90.15(n)1
    96.85(a)1
      1 (30.08 cM)5
    143691  NM_008057.31  NP_032083.31 
     594824245 
    chicken
    (Gallus gallus)
    Aves FZD71 frizzled family receptor 7 85.31(n)
    91.53(a)
      374060  NM_204221.2  NP_989552.1 
    lizard
    (Anolis carolinensis)
    Reptilia FZD76
    frizzled family receptor 7
    82(a)
    1 ↔ 1
    GL343208.1(4038808-4040586)
    African clawed frog
    (Xenopus laevis)
    Amphibia Fzd72 frizzled homolog 7 (Drosophila) 86.68(n)    AF179213.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fzd7a2 frizzled homolog 7a 84.44(n)   30369  AF336123.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fz3 determination of sensory organ
    precursor cell more
    47(a)     --


    ENSEMBL Gene Tree for FZD7 (if available)
    TreeFam Gene Tree for FZD7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FZD7 gene
    FZD32  FZD102  FZD82  FZD12  FZD52  FZD22  FZD92  SFRP42  
    SMO2  FZD42  FZD62  SFRP12  FRZB2  SFRP52  SFRP22  
    10 SIMAP similar genes for FZD7 using alignment to 1 protein entry:     FZD7_HUMAN:
    FZD1    FZD2    GPCR    FZD6    FZD5    FZD10
    FZD3    FZD9    FZD8    FZD4

    FZD7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FZD7 (see all 152)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1840998211,2
    --202897319(+) ATATTA/CCTGGC 1 -- us2k10--------
    rs22805091,2
    C,F,H--202897368(+) ACCCCC/TGCAGG 1 -- us2k119Minor allele frequency- T:0.21EA MN NS NA 3616
    rs130204971,2
    C,F,H--202897519(+) TAGCCT/AGGTTT 1 -- us2k115Minor allele frequency- A:0.21NS EA NA WA CSA 682
    rs129945681,2
    C,F,H--202897576(+) AAATGG/CTTGCT 1 -- us2k131Minor allele frequency- C:0.20NA NS EA MN WA CSA 2068
    rs67079381,2
    C,F,H--202897636(+) CACACA/C/GGGGCC 1 -- us2k111MN NS EA WA NA 1066
    rs358973531,2
    C,F--202897942(+) GGGGAG/CAGGGG 1 -- us2k15Minor allele frequency- C:0.01MN 400
    rs130003171,2
    C,F,H--202898137(+) GTCCTC/TGCTCC 1 -- us2k120Minor allele frequency- T:0.21NS EA NA WA CSA 1862
    rs1495920651,2
    --202898379(+) GACTTC/GCGCCC 1 -- us2k10--------
    rs1442715911,2
    C--202898486(+) GGGGAC/GGGGAG 1 -- us2k10--------
    rs1888394121,2
    --202898487(+) GGGAGA/GGGAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FZD7 (202899310 - 202903160 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FZD7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv29879CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FZD7
    DNA2.0 Custom Variant and Variant Library Synthesis for FZD7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603410    OMIM disorders: --

    15 diseases for FZD7:    
    About MalaCards
    exudative vitreoretinopathy    skeletal muscle regeneration    esophagitis    lung cancer susceptibility
    cleft lip    conduct disorder    basal cell carcinoma    glioblastoma multiforme
    hepatocellular carcinoma    colorectal cancer    lung cancer    ataxia
    endotheliitis    breast cancer    neuronitis


    FZD7 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for FZD7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 46 1 15870913 (1)
    gastric cancer 43.4 6 11408930 (4), 15870913 (1)

    Genetic Association Database (GAD): FZD7
    Human Genome Epidemiology (HuGE) Navigator: FZD7 (10 documents)
    Tumor Gene Database (TGDB): FZD7

    Export disorders for FZD7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FZD7 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with FZD7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. (PubMed id 9707618)1, 2, 3, 9 Tanaka S.... Sugimachi K. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    2. Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7. (PubMed id 9813155)1, 2, 3, 9 Sagara N.... Katoh M. (Biochem. Biophys. Res. Commun. 1998)
    3. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    5. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    6. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    7. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    8. Non-association between polymorphisms of the frizzled receptor genes and bone mineral density in postmenopausal Korean women. (PubMed id 19543507)1, 4 Kim J.G....Moon S.Y. (J. Korean Med. Sci. 2009)
    9. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    10. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PubMed id 18951430)1, 4 Anney R.J....Gill M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8324 HGNC: 4045 AceView: FZD7 Ensembl:ENSG00000155760 euGenes: HUgn8324
    ECgene: FZD7 Kegg: 8324 H-InvDB: FZD7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FZD7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FZD7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FZD7 gene:
    Search GeneIP for patents involving FZD7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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