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Aliases for FZD7 Gene

Aliases for FZD7 Gene

  • Frizzled Class Receptor 7 2 3
  • Frizzled 7, Seven Transmembrane Spanning Receptor 2 3
  • Frizzled Family Receptor 7 2 3
  • Fz-7 3 4
  • FzE3 3 4
  • HFz7 3 4
  • Frizzled, Drosophila, Homolog Of, 7 3
  • Frizzled (Drosophila) Homolog 7 2
  • Frizzled Homolog 7 (Drosophila) 2
  • Frizzled Homolog 7 3

External Ids for FZD7 Gene

Previous GeneCards Identifiers for FZD7 Gene

  • GC02P201116
  • GC02P201623
  • GC02P202863
  • GC02P203101
  • GC02P202724
  • GC02P202607
  • GC02P194748

Summaries for FZD7 Gene

Entrez Gene Summary for FZD7 Gene

  • Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for FZD7 Gene

FZD7 (Frizzled Class Receptor 7) is a Protein Coding gene. Diseases associated with FZD7 include exudative vitreoretinopathy and hepatocellular carcinoma. Among its related pathways are Signaling by GPCR and Pathways in cancer. GO annotations related to this gene include G-protein coupled receptor activity and PDZ domain binding. An important paralog of this gene is FZD10.

UniProtKB/Swiss-Prot for FZD7 Gene

  • Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues

Gene Wiki entry for FZD7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FZD7 Gene

Genomics for FZD7 Gene

Regulatory Elements for FZD7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FZD7 Gene

Chromosome:
2
Start:
202,034,587 bp from pter
End:
202,038,445 bp from pter
Size:
3,859 bases
Orientation:
Plus strand

Genomic View for FZD7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FZD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FZD7 Gene

Proteins for FZD7 Gene

  • Protein details for FZD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75084-FZD7_HUMAN
    Recommended name:
    Frizzled-7
    Protein Accession:
    O75084
    Secondary Accessions:
    • O94816
    • Q53S59
    • Q96B74

    Protein attributes for FZD7 Gene

    Size:
    574 amino acids
    Molecular mass:
    63620 Da
    Quaternary structure:
    • Interacts with MAGI3 and DVL1 (By similarity). Interacts with MYOC.

neXtProt entry for FZD7 Gene

Proteomics data for FZD7 Gene at MOPED

Post-translational modifications for FZD7 Gene

  • Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
  • Glycosylation at Ser 42, Asn 63, and Asn 164
  • Modification sites at PhosphoSitePlus

Other Protein References for FZD7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FZD7 Gene

Domains & Families for FZD7 Gene

Gene Families for FZD7 Gene

Protein Domains for FZD7 Gene

Suggested Antigen Peptide Sequences for FZD7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75084

UniProtKB/Swiss-Prot:

FZD7_HUMAN :
  • Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
  • Belongs to the G-protein coupled receptor Fz/Smo family.
Domain:
  • Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
  • The FZ domain is involved in binding with Wnt ligands.
  • Contains 1 FZ (frizzled) domain.
Family:
  • Belongs to the G-protein coupled receptor Fz/Smo family.
genes like me logo Genes that share domains with FZD7: view

Function for FZD7 Gene

Molecular function for FZD7 Gene

GENATLAS Biochemistry:
Drosophila frizzled polarity gene homolog,G protein coupled receptor superfamily,exhibiting characteristics of a WNT receptor,expressed in fetal kidney and adult skeletal muscle,heart,brain and placenta
UniProtKB/Swiss-Prot Function:
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues

Gene Ontology (GO) - Molecular Function for FZD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity IBA --
GO:0005109 frizzled binding IPI 19188438
GO:0005515 protein binding IPI 18256285
GO:0017147 Wnt-protein binding IPI 18313787
genes like me logo Genes that share ontologies with FZD7: view
genes like me logo Genes that share phenotypes with FZD7: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FZD7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FZD7 Gene

Localization for FZD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FZD7 Gene

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FZD7 Gene COMPARTMENTS Subcellular localization image for FZD7 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FZD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane TAS 9707618
genes like me logo Genes that share ontologies with FZD7: view

Pathways & Interactions for FZD7 Gene

genes like me logo Genes that share pathways with FZD7: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for FZD7 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for FZD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IMP 18681827
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0010812 negative regulation of cell-substrate adhesion IMP 18156211
GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA --
genes like me logo Genes that share ontologies with FZD7: view

Drugs & Compounds for FZD7 Gene

(2) Drugs for FZD7 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
leucine Nutra 93
genes like me logo Genes that share compounds with FZD7: view

Transcripts for FZD7 Gene

mRNA/cDNA for FZD7 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(124) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FZD7 Gene

Frizzled family receptor 7:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FZD7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FZD7 Gene

No ASD Table

Relevant External Links for FZD7 Gene

GeneLoc Exon Structure for
FZD7
ECgene alternative splicing isoforms for
FZD7

Expression for FZD7 Gene

mRNA expression in normal human tissues for FZD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FZD7 Gene

This gene is overexpressed in Seminal vesicle (39.4), Placenta (17.5), and Fetal gut (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FZD7 Gene



SOURCE GeneReport for Unigene cluster for FZD7 Gene Hs.173859

mRNA Expression by UniProt/SwissProt for FZD7 Gene

O75084-FZD7_HUMAN
Tissue specificity: High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas
genes like me logo Genes that share expression patterns with FZD7: view

Protein tissue co-expression partners for FZD7 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FZD7 Gene

Orthologs for FZD7 Gene

This gene was present in the common ancestor of animals.

Orthologs for FZD7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FZD7 35
  • 92.92 (n)
  • 97.04 (a)
FZD7 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FZD7 35
  • 93.55 (n)
  • 98.08 (a)
FZD7 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fzd7 35
  • 90.15 (n)
  • 96.85 (a)
Fzd7 16
Fzd7 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FZD7 35
  • 99.65 (n)
  • 100 (a)
FZD7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100360552 35
  • 90.15 (n)
  • 96.85 (a)
oppossum
(Monodelphis domestica)
Mammalia FZD7 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FZD7 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves FZD7 35
  • 85.31 (n)
  • 91.53 (a)
FZD7 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FZD7 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fzd7 35
  • 82.61 (n)
  • 89.79 (a)
African clawed frog
(Xenopus laevis)
Amphibia Fzd7 35
zebrafish
(Danio rerio)
Actinopterygii fzd7a 35
fzd7a 36
  • 82 (a)
OneToMany
fzd7b 36
  • 80 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta fz 37
  • 47 (a)
fz 36
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cfz-2 37
  • 36 (a)
mom-5 37
  • 38 (a)
Species with no ortholog for FZD7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FZD7 Gene

ENSEMBL:
Gene Tree for FZD7 (if available)
TreeFam:
Gene Tree for FZD7 (if available)

Paralogs for FZD7 Gene

Paralogs for FZD7 Gene

(10) SIMAP similar genes for FZD7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FZD7: view

Variants for FZD7 Gene

Sequence variations from dbSNP and Humsavar for FZD7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1801859 -- 202,038,239(+) ATCTT(C/T)TGTGC utr-variant-3-prime
rs2280509 -- 202,032,645(+) ACCCC(C/T)GCAGG upstream-variant-2KB
rs4673222 -- 202,037,187(+) AAGAA(A/G)TGATG utr-variant-3-prime
rs6707938 -- 202,032,913(+) CACAC(A/C/G)GGGCC upstream-variant-2KB
rs11546413 -- 202,035,491(+) GGCGC(C/T)TCAGC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for FZD7 Gene

Variant ID Type Subtype PubMed ID
esv29879 CNV Loss 19812545

Variation tolerance for FZD7 Gene

Residual Variation Intolerance Score: 3.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 30.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FZD7 Gene

HapMap Linkage Disequilibrium report
FZD7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FZD7 Gene

Disorders for FZD7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FZD7 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
exudative vitreoretinopathy
  • exudative vitreoretinopathy 1
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
colorectal cancer
  • colorectal cancer, somatic
- elite association
Search FZD7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FZD7

Genetic Association Database (GAD)
FZD7
Human Genome Epidemiology (HuGE) Navigator
FZD7
Tumor Gene Database (TGDB):
FZD7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FZD7
genes like me logo Genes that share disorders with FZD7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FZD7 Gene

Publications for FZD7 Gene

  1. Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7. (PMID: 9813155) Sagara N. … Katoh M. (Biochem. Biophys. Res. Commun. 1998) 2 23 67
  2. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. (PMID: 9707618) Tanaka S. … Sugimachi K. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 23 67
  3. Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells. (PMID: 19773752) Ueno K. … Hinoda Y. (Br. J. Cancer 2009) 23 67
  4. Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. (PMID: 18313787) Kim M. … Wands J.R. (J. Hepatol. 2008) 23 67
  5. Frizzled-7 as a potential therapeutic target in colorectal cancer. (PMID: 18592008) Ueno K. … Hinoda Y. (Neoplasia 2008) 23 67

Products for FZD7 Gene

Sources for FZD7 Gene

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