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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FZD7 Gene

protein-coding   GIFtS: 67
GCID: GC02P202863

frizzled family receptor 7

(Previous names: frizzled (Drosophila) homolog 7, frizzled homolog 7 (Drosophila),...)
 Explore 22 diseases affiliated with
FZD7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FZD7    

Aliases
for FZD7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Frizzled Family Receptor 71 2     Frizzled Homolog 72
FzE31 2 3     Frizzled, Drosophila, Homolog Of, 72
Frizzled 7, Seven Transmembrane Spanning Receptor1 2     Frizzled-71
HFz71     Fz-73
Frizzled (Drosophila) Homolog 71     Fz-73
Frizzled Homolog 7 (Drosophila)1     

External Ids:    HGNC: 40451   Entrez Gene: 83242   Ensembl: ENSG000001557607   OMIM: 6034105   UniProtKB: O750843   

Export aliases for FZD7 gene to outside databases

Previous GC identifers: GC02P201116 GC02P201623 GC02P203101 GC02P202724 GC02P202607 GC02P194748


Summaries
for FZD7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FZD7:
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling
proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich
extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with
a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated
signals in poorly differentiated human esophageal carcinomas. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FZD7_HUMAN, O75084
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling
pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of
beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been
seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated
in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways
seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of
polarity information during tissue morphogenesis and/or in differentiated tissues

Gene Wiki entry for FZD7


Genomic Views
for FZD7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FZD7 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   LCR-F1   NF-kappaB   E2F   E2F-1   Chx10   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FZD7 promoter sequence
   Search SABiosciences Chromatin IP Primers for FZD7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FZD7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33

FZD7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZD7 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P202863:  view genomic region     (about GC identifiers)

Start:
 202,899,310 bp from pter      End:
 202,903,160 bp from pter
Size:
 3,851 bases      Orientation:
 plus strand

Proteins
for FZD7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FZD7_HUMAN, O75084 (See protein sequence)
Recommended Name: Frizzled-7 precursor  
Size: 574 amino acids; 63620 Da
Subunit: Interacts with MAGI3 and DVL1 (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein (By similarity). Cell membrane; Multi-pass membrane protein
(By similarity)
Secondary accessions: O94816 Q53S59 Q96B74

Explore the universe of human proteins at neXtProt for FZD7: NX_O75084

Post-translational modifications:

  • Ubiquitinated by ZNRF3, leading to its degradation by the proteasome (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75084

    • FZD7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003498.1  
    ENSEMBL proteins: 
     ENSP00000286201  
    Reactome Protein details: O75084
    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for FZD7 (Frizzled-7)
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    OriGene Protein Over-expression Lysate: FZD7
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    Novus Biologicals FZD7 Proteins
    Novus Biologicals FZD7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FZD7

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005886plasma membrane IDA18256285
    GO:0016021integral to membrane TAS9707618
    GO:0032589neuron projection membrane IBA--
    GO:0045177apical part of cell IBA--


    FZD7 for ontologies           About GeneDecksing



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    Assay Products for FZD7: 
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    Uscn ELISAs and CLIAs for FZD7

    Protein Domains /
    Families
    for FZD7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FZD7 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000539 Frizzled
     IPR020067 Frizzled_dom
     IPR026552 FZD7
     IPR015526 Frizzled/SFRP
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry O75084

    ProtoNet protein and cluster: O75084

    1 Blocks protein family: IPB000539 Frizzled protein signature

    UniProtKB/Swiss-Prot: FZD7_HUMAN, O75084
    Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the
    activation of the Wnt/beta-catenin signaling pathway (By similarity)
    Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
    Similarity: Belongs to the G-protein coupled receptor Fz/Smo family
    Similarity: Contains 1 FZ (frizzled) domain


    Function
    for FZD7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FZD7_HUMAN, O75084
    Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling
    pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of
    beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been
    seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated
    in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways
    seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of
    polarity information during tissue morphogenesis and/or in differentiated tissues

         Genatlas biochemistry entry for FZD7:
    Drosophila frizzled polarity gene homolog,G protein coupled receptor superfamily,exhibiting characteristics of a WNT
    receptor,expressed in fetal kidney and adult skeletal muscle,heart,brain and placenta

    miRNA
    Products:            		miRTarBase miRNAs that target FZD7:
    hsa-mir-145 (MIRT005690)

    OriGene 3'-UTR Clone: FZD7
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FZD7
    8/70 QIAGEN miScript miRNA Assays for microRNAs that regulate FZD7 (see all 70):
    hsa-miR-548j hsa-miR-607 hsa-miR-106a hsa-miR-128 hsa-miR-138-2* hsa-miR-877* hsa-miR-1273d hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmid: FZD7 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FZD7 (see all 4)
    OriGene shRNA RFP: FZD7
    OriGene siRNA: FZD7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FZD7

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: FZD7 (NM_003507)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FZD7 

    Cell Line
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    Search LifeMap BioReagents cell lines for FZD7

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD7

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005515protein binding ----
    GO:0017147Wnt-protein binding IPI18313787
    GO:0030165PDZ domain binding IPI18256285
    GO:0042813Wnt-activated receptor activity IBA--


    FZD7 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for FZD7:
     Decreased substrate adherent c  Increased G2M DNA content  Increased cell death HMECs cel  Increased number of mitotic ce 

    Animal Models:
         10 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fzd7):
     cardiovascular system  craniofacial  digestive/alimentary  embryogenesis  growth/size 
     integument  limbs/digits/tail  mortality/aging  nervous system  pigmentation 

    FZD7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FZD7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt Signaling Pathway
    		Wnt Signaling Pathway1.00
    		Wnt signaling pathway0.30
    		Wnt Signaling Pathway and Pluripotency0.55
    		Wnt Signaling Pathway NetPath0.22
    		Wnt Signaling Pathway0.33
    2Translation_Non-genomic (rapid) action of Androgen Receptor
    		Translation_Non-genomic (rapid) action of Androgen Receptor1.00
    		Translation Non-genomic (rapid) action of Androgen Receptor0.99
    3Transcription_Androgen Receptor nuclear signaling
    		Transcription_Androgen Receptor nuclear signaling1.00
    		Transcription Androgen Receptor nuclear signaling0.99
    4Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		GSK3 Signaling0.61
    5Human Embryonic Stem Cell Pluripotency
    		Human Embryonic Stem Cell Pluripotency1.00
    		Factors Promoting Cardiogenesis in Vertebrates0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for FZD7
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 R&D Systems Pathway for FZD7
        Wnt Signaling Pathway

    5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FZD7 (see all 11)
        Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Colorectal Cancer Metastasis
    Glioblastoma Multiforme

    2 GeneGo (Thomson Reuters) Pathways for FZD7
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    5/6 BioSystems Pathways for FZD7 (see all 6) 
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway NetPath
    Wnt signaling network
    Noncanonical Wnt signaling pathway

    4        Reactome Pathways for FZD7
        Signal Transduction
    Signaling by GPCR
    GPCR ligand binding
    Class B/2 (Secretin family receptors)


    4         Kegg Pathways  (Kegg details for FZD7):
        Wnt signaling pathway
    Melanogenesis
    Pathways in cancer
    Basal cell carcinoma


    FZD7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FZD7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/48 Interacting proteins for FZD7 (O750842, 3 ENSP000002862014) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN1Q9UMX02, 3, ENSP000003655764MINT-66943 I2D: score=5 STRING: ENSP00000365576
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2864936 I2D: score=3 STRING: ENSP00000357292
    DLG4P783523, ENSP000002938134I2D: score=3 STRING: ENSP00000293813
    DLG1Q129593, ENSP000003457314I2D: score=2 STRING: ENSP00000345731
    MAGI3Q5TCQ93, ENSP000003046044I2D: score=1 STRING: ENSP00000304604
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001944vasculature development IBA--
    GO:0006355regulation of transcription, DNA-dependent IMP18681827
    GO:0007199G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger IBA--
    GO:0007223Wnt receptor signaling pathway, calcium modulating pathway IBA--
    GO:0007409axonogenesis IBA--


    FZD7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FZD7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FZD7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FZD7

    1 HMDB Compound for FZD7    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    1 Novoseek chemical compound relationship for FZD7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 37.1 3 15870913 (2)

    Search CenterWatch for drugs/clinical trials and news about FZD7 

    Transcripts
    for FZD7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FZD7 gene: 
    NM_003507.1  

    Unigene Cluster for FZD7:

    Frizzled family receptor 7
    Hs.173859  [show with all ESTs]
    Unigene Representative Sequence: AB017365
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000286201(uc002uyw.1)

    miRNA
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    hsa-miR-548j hsa-miR-607 hsa-miR-106a hsa-miR-128 hsa-miR-138-2* hsa-miR-877* hsa-miR-1273d hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmid: FZD7 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB010881.1 AB017365.1 AL110146.1 BC015915.1 

    1 DOTS entry:

    DT.445208 

    24/124 AceView cDNA sequences (see all 124):

    AI333651 BM992571 AA938994 W00697 BQ002052 AA778339 W52682 AW337763 
    CB158179 AI002187 BQ181891 AI074303 AI129705 BF434722 AI189384 AW072200 
    BU848687 BQ021995 NM_003507 AA582269 BC015915 AA903072 AA612575 BU931818 

    GeneLoc Exon Structure


    Expression
    for FZD7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FZD7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACAGATCAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FZD7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Endothelial cells and neural cells (Derivation of blood-...)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FZD7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FZD7

    SOURCE GeneReport for Unigene cluster: Hs.173859

    UniProtKB/Swiss-Prot: FZD7_HUMAN, O75084
    Tissue specificity: High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart,
    brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas

        SABiosciences Expression via Pathway-Focused PCR Arrays including FZD7 (see all 7): 
              G Protein Coupled Receptors 384HT in human mouse rat
              WNT Signaling Targets in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat
              Liver Cancer in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FZD7
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD7

    Orthologs
    for FZD7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FZD7 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FZD71 frizzled family receptor 7 84.59(n)
    90.29(a)    		   374060  NM_204221.1  NP_989552.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FZD76
    		 --
    		 81(a)
    		 1 ↔ 1
    		 GL343208.1(4038808-4040586)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Fzd72 frizzled homolog 7 (Drosophila) 86.68(n)    AF179213.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii fzd7a2 frizzled homolog 7a 84.44(n)   30369  AF336123.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta fz1 , 3 determination of sensory organ precursor
    cell more3
    frizzled1    		 47(a)3
    57.07(n)1
    51.63(a)1    		   453071  NM_080073.21  NP_524812.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea mom-53 Drosophila tissue polarity protein like 38(a)
    (best of 2)    		   I(9973695-9977388)   --


    ENSEMBL Gene Tree for FZD7 (if available)
    TreeFam Gene Tree for FZD7 (if available) 

    Paralogs
    for FZD7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FZD7 gene
    FZD102  FZD32  FZD82  FZD12  FZD52  FZD22  FZD92  SFRP42  
    SMO2  FZD42  FZD62  SFRP12  FRZB2  SFRP52  SFRP22  
    10 SIMAP similar genes for FZD7 using alignment to 1 protein entry:     FZD7_HUMAN:
    FZD1    FZD2    GPCR    FZD6    FZD5    FZD10
    FZD3    FZD9    FZD8    FZD4

    FZD7 for paralogs           About GeneDecksing



    Genomic Variants
    for FZD7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/106 NCBI SNPs in FZD7 are shown (see all 106)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1840998211,2
    		--202897319(+) ATATTA/CCTGGC 1 -- us2k10--------
    rs22805091,2
    		C,F,H,--202897368(+) ACCCCC/TGCAGG 1 -- us2k119Minor allele frequency- T:0.21EA MN NS NA 3616
    rs130204971,2
    		C,F,H,--202897519(+) TAGCCT/AGGTTT 1 -- us2k115Minor allele frequency- A:0.21NS EA NA WA CSA 682
    rs129945681,2
    		C,F,H,--202897576(+) AAATGG/CTTGCT 1 -- us2k131Minor allele frequency- C:0.20NA NS EA MN WA CSA 2068
    rs67079381,2
    		C,F,H,--202897636(+) CACACA/C/GGNNNN 1 -- us2k111MN NS EA WA NA 1066
    rs358973531,2
    		F--202897942(+) GGGGAG/CAGGGG 1 -- us2k15Minor allele frequency- C:0.01MN 400
    rs130003171,2
    		C,F,H,--202898137(+) GTCCTC/TGCTCC 1 -- us2k120Minor allele frequency- T:0.21NS EA NA WA CSA 1862
    rs1495920651,2
    		--202898379(+) GACTTC/GCGCCC 1 -- us2k10--------
    rs1442715911,2
    		--202898486(+) GGGGAC/GGGGAG 1 -- us2k10--------
    rs1888394121,2
    		--202898487(+) GGGAGA/GGGAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FZD7 (202899310 - 202903160 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for FZD7
         1 CNV: 68222

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    Disorders / Diseases
    for FZD7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FZD7 for disorders           About GeneDecksing

    OMIM gene information: 603410    OMIM disorders: --

    20/22 diseases for FZD7 (see all 22):    About MalaCards
    esophageal carcinoma    skeletal muscle regeneration    esophagitis    cleft lip/palate
    carcinoma    exudative vitreoretinopathy    cleft lip    vitreoretinopathy
    conduct disorder    basal cell carcinoma    hepatocellular carcinoma    gastric cancer
    adhd    pulmonary disease    liver cancer    colon cancer
    breast carcinoma    colorectal cancer    breast cancer    ataxia

    2 Novoseek disease relationships for FZD7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 46 1 15870913 (1)
    gastric cancer 43.4 6 11408930 (4), 15870913 (1)

    Human Genome Epidemiology (HuGE) Navigator: FZD7 (10 documents)
    Tumor Gene Database (TGDB): FZD7

    Export disorders for FZD7 gene to outside databases

    Publications
    for FZD7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FZD7 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with FZD7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. (PubMed id 9707618)1, 2, 3, 9 Tanaka S.... Sugimachi K. (1998)
    2. Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7. (PubMed id 9813155)1, 2, 3, 9 Sagara N.... Katoh M. (1998)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Down-regulation of frizzled-7 expression decreases su rvival, invasion and metastatic capabilities of colon cancer cells. (PubMed id 19773752)1, 9 Ueno K....Hinoda Y. (2009)
    5. Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. (PubMed id 18313787)1, 9 Kim M....Wands J.R. (2008)
    6. Frizzled-7 as a potential therapeutic target in colorectal cancer. (PubMed id 18592008)1, 9 Ueno K....Hinoda Y. (2008)
    7. Soluble Frizzled-7 receptor inhibits Wnt signaling an d sensitizes hepatocellular carcinoma cells towards doxorubicin. (PubMed id 21314951)1 Wei W....So S.K. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. FZD7 has a critical role in cell proliferation in tri ple negative breast cancer. (PubMed id 21532620)1 Yang L....Yen Y. (2011)

    External Searches for FZD7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FZD7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8324 HGNC: 4045 AceView: FZD7 Ensembl:ENSG00000155760 euGenes: HUgn8324
    ECgene: FZD7 Kegg: 8324 H-InvDB: FZD7

    Other Databases showing FZD7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FZD7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FZD7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FZD7 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for FZD7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FZD7 gene:
    Search GeneIP for patents involving FZD7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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