Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FZD6 Gene

protein-coding GIFtS: 66
GCID: GC08P104267

frizzled family receptor 6

(Previous names: frizzled (Drosophila) homolog 6, frizzled homolog 6 (Drosophila),...)

Explore 18 diseases affiliated with
FZD6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Frizzled Family Receptor 6¹ ²		HFZ6²
Frizzled 6, Seven Transmembrane Spanning Receptor¹ ²		NDNC10²
Hfz6¹		Frizzled Homolog 6²
Frizzled (Drosophila) Homolog 6¹		Frizzled-6¹
Frizzled Homolog 6 (Drosophila)¹		Seven Transmembrane Helix Receptor²
FZ-6²		Fz-6³
FZ6²		HFz6¹

External Ids:	HGNC: 4044¹	Entrez Gene: 8323²	Ensembl: ENSG00000164930⁷	OMIM: 603409⁵	UniProtKB: O60353³

Export aliases for FZD6 gene to outside databases

Previous GC identifers: GC08P103316 GC08P104379 GC08P103979 GC08P099511

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FZD6:

This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are

receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a

cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family

members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative

regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic

transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript

variants, some of which do not encode a protein with a predicted signal peptide.(provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: FZD6_HUMAN, O60353

Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling

pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of

beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been

seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated

in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways

seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of

polarity information during tissue morphogenesis and/or in differentiated tissues

Gene Wiki entry for FZD6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008046.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FZD6 gene promoter:
AML1a HTF STAT5A LCR-F1 POU2F1 E2F-1 E2F POU2F1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FZD6 promoter sequence

Search SABiosciences Chromatin IP Primers for FZD6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FZD6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.3-q23.1 Ensembl cytogenetic band: 8q22.3 HGNC cytogenetic band: 8q22.3-q23.1

FZD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZD6 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P104267: view genomic region (about GC identifiers)

Start:	104,310,661 bp from pter	End:	104,345,094 bp from pter
Size:	34,434 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FZD6_HUMAN, O60353 (See protein sequence)

Recommended Name: Frizzled-6 precursor

Size: 706 amino acids; 79292 Da

Subcellular location: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By similarity)

Secondary accessions: B4DRN0 Q6N0A5 Q6P9C3 Q8WXR9

Alternative splicing: 2 isoforms: O60353-1 O60353-2

Explore the universe of human proteins at neXtProt for FZD6: NX_O60353

Post-translational modifications:

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O60353

FZD6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001158087.1 NP_001158088.1 NP_003497.2

ENSEMBL proteins:

ENSP00000429055 ENSP00000428301 ENSP00000428257 ENSP00000429528 ENSP00000427733

ENSP00000428188 ENSP00000351605 ENSP00000443757

Reactome Protein details: O60353
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): FZD6 OriGene Custom Protein Services for FZD6
	GenScript Custom Purified and Recombinant Proteins Services for FZD6
	Novus Biologicals FZD6 Protein Novus Biologicals FZD6 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FZD6

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IBA	--
GO:0005886	plasma membrane	IDA	--
GO:0005887	integral to plasma membrane	ISS	15265686
GO:0016021	integral to membrane	--	--
GO:0016327	apicolateral plasma membrane	IBA	--

FZD6 for ontologies About GeneDecksing

FZD6 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for FZD6 (Frizzled-6)
	Cell Signaling Technology (CST) Antibodies for FZD6
	OriGene Antibodies: FZD6 OriGene Custom Antibody Services for FZD6
	GenScript Custom Superior Antibodies Services for FZD6
	Novus Biologicals FZD6 Antibodies
	Abcam antibodies for FZD6
	Uscn Antibodies for FZD6
	ThermoFisher Antibodies for FZD6

Assay Products for FZD6:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FZD6
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FZD6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FZD6 for domains About GeneDecksing

5 InterPro domains/families:

IPR000539 Frizzled

IPR026543 FZD6

IPR020067 Frizzled_dom

IPR015526 Frizzled/SFRP

IPR017981 GPCR_2-like

Graphical View of Domain Structure for InterPro Entry O60353

ProtoNet protein and cluster: O60353

1 Blocks protein family: IPB000539 Frizzled protein signature

UniProtKB/Swiss-Prot: FZD6_HUMAN, O60353

Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the

activation of the Wnt/beta-catenin signaling pathway (By similarity)

Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)

Similarity: Belongs to the G-protein coupled receptor Fz/Smo family

Similarity: Contains 1 FZ (frizzled) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FZD6_HUMAN, O60353

Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling

pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of

beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been

seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated

in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways

seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of

polarity information during tissue morphogenesis and/or in differentiated tissues

Genatlas biochemistry entry for FZD6:

Drosophila frizzled polarity gene homolog,G protein coupled receptor superfamily,exhibiting characteristics of a WNT

receptor,expressed in various normal adult and fetal tissues,involved in signal transduction,activating Dishevelled

miRNA Products:		OriGene 3'-UTR Clone (see all 3): FZD6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FZD6
		8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate FZD6 (see all 39):
		hsa-miR-607 hsa-miR-302d hsa-miR-520e hsa-miR-15a hsa-miR-301a hsa-miR-519a hsa-miR-424 hsa-miR-372

		SwitchGear 3'UTR luciferase reporter plasmid: FZD6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FZD6 (see all 7) OriGene shRNA RFP: FZD6 OriGene siRNA: FZD6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FZD6

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for FZD6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FZD6 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FZD6 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): FZD6 (NM_001164615)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FZD6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FZD6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FZD6
		Search LifeMap BioReagents cell lines for FZD6

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD6

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0005515	protein binding	IPI	10347172
GO:0017147	Wnt-protein binding	ISS	15265686
GO:0030165	PDZ domain binding	IBA	--
GO:0031625	ubiquitin protein ligase binding	IPI	--

FZD6 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Fzd6^tm1Lex for FZD6
     9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Fzd6):

embryogenesis	hearing/vestibular/ear	integument	limbs/digits/tail	mortality/aging
nervous system	normal	reproductive system	vision/eye

FZD6 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Wnt Signaling Pathway

Wnt Signaling Pathway	1.00	Wnt signaling pathway	0.30
Wnt Signaling Pathway and Pluripotency	0.55	Wnt Signaling Pathway NetPath	0.22
Wnt Signaling Pathway	0.33

Translation_Non-genomic (rapid) action of Androgen Receptor

Translation_Non-genomic (rapid) action of Androgen Receptor

1.00

Translation Non-genomic (rapid) action of Androgen Receptor

0.99

Transcription_Androgen Receptor nuclear signaling

Transcription_Androgen Receptor nuclear signaling

1.00

Transcription Androgen Receptor nuclear signaling

0.99

Nanog in Mammalian ESC Pluripotency

Nanog in Mammalian ESC Pluripotency

1.00

GSK3 Signaling

0.61

Human Embryonic Stem Cell Pluripotency

Human Embryonic Stem Cell Pluripotency

1.00

Factors Promoting Cardiogenesis in Vertebrates

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for FZD6

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

1 R&D Systems Pathway for FZD6

Wnt Signaling Pathway

5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FZD6 (see all 11)

	Factors Promoting Cardiogenesis in Vertebrates
	Molecular Mechanisms of Cancer
	G12-G13 in Cellular Signaling
	Colorectal Cancer Metastasis
	Glioblastoma Multiforme

1 Cell Signaling Technology (CST) Pathway for FZD6

Wnt / Hedgehog / Notch

2 GeneGo (Thomson Reuters) Pathways for FZD6

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

4 BioSystems Pathways for FZD6

	Wnt Signaling Pathway and Pluripotency
	Wnt Signaling Pathway
	Wnt Signaling Pathway NetPath
	Wnt signaling network

4 Reactome Pathways for FZD6

	Signal Transduction
	Signaling by GPCR
	GPCR ligand binding
	Class B/2 (Secretin family receptors)

4 Kegg Pathways (Kegg details for FZD6):

	Wnt signaling pathway
	Melanogenesis
	Pathways in cancer
	Basal cell carcinoma

FZD6 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FZD6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/38 Interacting proteins for FZD6 (O60353³ ENSP00000351605⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
WNT4	P56705³, ENSP00000290167⁴	I2D: score=2 STRING: ENSP00000290167
SFRP1	Q8N474³, ENSP00000220772⁴	I2D: score=2 STRING: ENSP00000220772
CTHRC1	ENSP00000330523⁴	STRING: ENSP00000330523
DVL1	ENSP00000368169⁴	STRING: ENSP00000368169
DVL2	ENSP00000005340⁴	STRING: ENSP00000005340

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IBA	--
GO:0001736	establishment of planar polarity	IBA	--
GO:0001843	neural tube closure	IBA	--
GO:0001942	hair follicle development	IEA	--
GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	IBA	--

FZD6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FZD6

1 HMDB Compound for FZD6 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about FZD6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FZD6 gene (3 alternative transcripts):

NM_001164615.1 NM_001164616.1 NM_003506.3

Unigene Cluster for FZD6:

Frizzled family receptor 6

Hs.591863 [show with all ESTs]

Unigene Representative Sequence: BX538222

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000522566(uc003ylh.3) ENST00000522484 ENST00000523933 ENST00000523739

ENST00000519011 ENST00000521195 ENST00000358755(uc011lhn.2 uc003ylj.3 uc011lho.2 uc011lhp.2)

ENST00000540287

miRNA Products:		OriGene 3'-UTR Clone (see all 3): FZD6 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FZD6
		8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate FZD6 (see all 39):
		hsa-miR-607 hsa-miR-302d hsa-miR-520e hsa-miR-15a hsa-miR-301a hsa-miR-519a hsa-miR-424 hsa-miR-372

		SwitchGear 3'UTR luciferase reporter plasmid: FZD6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FZD6 (see all 7) OriGene shRNA RFP: FZD6 OriGene siRNA: FZD6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FZD6

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FZD6 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FZD6 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): FZD6 (NM_001164615)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FZD6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FZD6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FZD6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FZD6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FZD6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FZD6

Additional cDNA sequence:

AB012911.1 AB209734.1 AF072873.1 AK296824.1 AK299341.1 AK304092.1 AK313789.1 AK316544.1

BC036106.1 BC060836.1 BX538222.1 BX640609.1

12 DOTS entries:

DT.95265004 DT.100687502 DT.313636 DT.101982634 DT.92043230 DT.99972645 DT.121479276 DT.121479296

DT.121479236 DT.121479264 DT.313638 DT.95265002

24/119 AceView cDNA sequences (see all 119):

BU627239 CR623773 N57630 BX109942 AW148330 CA394506 AU131395 NM_003506

AU131025 BP351890 CD644741 AI220799 CA311380 CB850614 CA313845 BX477422

AA319328 BQ026138 BM995943 BX329173 BM770542 AU130184 AW511572 BG506706

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for FZD6 About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10
SP1:
SP2:													-
SP3:			-		-

ECgene alternative splicing isoforms for FZD6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FZD6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCACCCATT

About this image

FZD6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Somite

Cervical Dermomyotome

Cervical Dermomyotome Cells

Adipose, Skeletal Muscle

Somite

Cervical Dorsomedial Dermomyotome Lip

Muscle Progenitor Cells

Skeletal Muscle

Somite

Lumbar Dermomyotome

Lumbar Dermomyotome Cells

Adipose, Skeletal Muscle

Somite

Lumbar Dorsomedial Dermomyotome Lip

Muscle Progenitor Cells

Skeletal Muscle

Somite

Sacral Dermomyotome

Sacral Dermomyotome Cells

Adipose, Skeletal Muscle

Somite

Sacral Dorsomedial Dermomyotome Lip

Muscle Progenitor Cells

Skeletal Muscle

Somite

Thoracic Dermomyotome

Thoracic Dermomyotome Cells

Adipose, Skeletal Muscle

Somite

Thoracic Dorsomedial Dermomyotome Lip

Muscle Progenitor Cells

Skeletal Muscle

Kidney

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

Endothelial cells and neural cells (Derivation of blood-...)

See FZD6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FZD6

SOURCE GeneReport for Unigene cluster: Hs.591863

UniProtKB/Swiss-Prot: FZD6_HUMAN, O60353

Tissue specificity: Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus,

prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney

SABiosciences Expression via Pathway-Focused PCR Arrays including FZD6:

G Protein Coupled Receptors 384HT in human mouse rat

WNT Signaling Pathway in human mouse rat

Stem Cell Signaling in human mouse rat

Notch Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FZD6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FZD6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FZD6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FZD6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FZD6 gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FZD6¹	frizzled family receptor 6	74(n) 76.41(a)		378788 XM_418372.3 XP_418372.3
lizard (Anolis carolinensis)	Reptilia	FZD6⁶	--	71(a)	1 ↔ 1	4(13723379-13739450)
tropical clawed frog (Xenopus tropicalis)	Amphibia	AL857901.2²	--	73.01(n)		AL857901.2
zebrafish (Danio rerio)	Actinopterygii	zgc65879²	hypothetical protein MGC65879	73.56(n)		393533 BC056573.1

ENSEMBL Gene Tree for FZD6 (if available)
TreeFam Gene Tree for FZD6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FZD6 gene

FZD10² FZD3² FZD8² FZD1² FZD5² FZD2² FZD9² SFRP4²

SMO² FZD4² SFRP1² FRZB² FZD7² SFRP5² SFRP2²

11 SIMAP similar genes for FZD6 using alignment to 6 protein entries: FZD6_HUMAN (see all proteins):

GPCR FZD3 FZD1 FZD2 FZD7 FZD10

FZD9 SMO FZD4 FZD5 FRZB

FZD6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75892544^1,2	C,F,	--	99510253(+)	`AAATCA/GCATGA`	3	--	int¹ us2k¹		2		NA EA	240
rs75017383^1,2	F,	--	99510467(+)	`ACCACG/ATAGAC`	3	--	us2k¹		1		WA	118
rs199657806^1,2	C	--	99510869(+)	`CCTGAA/CAAAAA`	3	--	us2k¹		0	--	--	--	--
rs78541197^1,2	F,	--	99511175(+)	`AGAGAA/CATAGT`	3	--	us2k¹		1		NA	120
rs76971805^1,2	C,F,	--	99511284(+)	`TATTTC/ATTCAT`	3	--	us2k¹		1		WA	118
rs6468868^1,2	C,F,A,H,	--	99511357(+)	`AATTCG/ATCTTT`	3	--	us2k¹		13		NS EA NA	1760
rs77169858^1,2	C,F,	--	99511473(+)	`AGCCTC/TCATCT`	3	--	us2k¹		1		WA	118
rs78475112^1,2		--	99511663(+)	`CTATAT/CTGTGA`	3	--	us2k¹		2		CSA WA	120
rs3758096^1,2	C,H	--	99511741(-)	`AAATCA/CACCTA`	3	--	us2k¹		4		NS EA	418
rs74949239^1,2	F,	--	99512578(+)	`TTGGGG/ACGCGG`	3	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for FZD6 (104310661 - 104345094 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FZD6: --
Human Gene Mutation Database (HGMD): FZD6

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FZD6

DNA2.0 Custom Variant and Variant Library Synthesis for FZD6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FZD6 for disorders About GeneDecksing

OMIM gene information: 603409 OMIM disorders: --

UniProtKB/Swiss-Prot: FZD6_HUMAN, O60353

Defects in FZD6 are the cause of nail disorder non-syndromic congenital type 10 (NDNC10) [MIM:614157]. NDNC10

is a nail disorder characterized by a variable degree of onychauxis (thick nails), hyponychia, and onycholysis of all

nails, with claw-shaped fingernails in some individuals. No other anomalies of ectodermal tissues, including hair,

teeth, sweat glands, or skin, are noted, and individuals with dysplastic nails have normal hearing and normal

psychomotor development

Note=Rare non-synonymous variants in FZD6 may contribute to neural tube defects, congenital malformations of

the central nervous system and adjacent structures related to defective neural tube closure during the first trimester

of pregnancy

18 diseases for FZD6: About MalaCards

neural tube defect exudative vitreoretinopathy nail dysplasia vitreoretinopathy

basal cell carcinoma hyperopia pituitary adenoma strabismus

acute leukemia adenoma hematopoiesis breast cancer

leukemia carcinoma prostatitis neuronitis

colorectal cancer glioblastoma

1 disease from the University of Copenhagen DISEASES database for FZD6:

Hyperopia

Human Genome Epidemiology (HuGE) Navigator: FZD6 (4 documents)
Tumor Gene Database (TGDB): FZD6

Export disorders for FZD6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FZD6 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with FZD6)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning of human frizzled-6. (PubMed id 9480858)^{1, 2, 3, 9} Tokuhara M.... Katoh M. (1998)
FZD6 is a novel gene for human neural tube defects. (PubMed id 22045688)^{1, 2} De Marco P....Capra V. (2011)
Mutations in Frizzled 6 cause isolated autosomal-recessive nail dysplasia. (PubMed id 21665003)^{1, 2} Frojmark A.S.... Dahl N. (2011)
The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade. (PubMed id 14747478)^{1, 3} Golan T....Gazit A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
FZD6 encoding the Wnt receptor frizzled 6 is mutated i n autosomal-recessive nail dysplasia. (PubMed id 22211385)¹ Naz G....Betz R.C. (2012)
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. (PubMed id 22575959)² Hao H.X....Cong F. (2012)
Analysis of target genes regulated by chronic electroc onvulsive therapy reveals role for Fzd6 in depression. (PubMed id 21937024)¹ Voleti B....Duman R.S. (2012)
[Of genes and nails]. (PubMed id 22078044)¹ Dereure O. (2011)
Frizzled receptor 6 marks rare, highly tumourigenic st em-like cells in mouse and human neuroblastomas. (PubMed id 22249030)¹ Cantilena S....Sala A. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8323	HGNC: 4044	AceView: FZD6	Ensembl:ENSG00000164930	euGenes: HUgn8323
ECgene: FZD6	Kegg: 8323	H-InvDB: FZD6

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FZD6	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FZD6	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for FZD6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FZD6 gene:
Search GeneIP for patents involving FZD6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for FZD6 (Frizzled-6)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for FZD6		OriGene shRNA RFP for FZD6
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FZD6		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FZD6
	OriGene Protein Over-expression Lysate for FZD6		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for FZD6		OriGene 3'-UTR Clone for FZD6
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FZD6		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FZD6
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for FZD6		OriGene Custom Protein Services for FZD6
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FZD6
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FZD6
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FZD6
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FZD6
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FZD6
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FZD6

	GenScript Custom Purified and Recombinant Proteins Services for FZD6		GenScript cDNA clones with any tag delivered in your preferred vector for FZD6
	GenScript Custom Assay Services for FZD6		GenScript Custom Superior Antibodies Services for FZD6
	GenScript Custom overexpressing Cell Line Services for FZD6		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for FZD6

	Regulatory tfbs in FZD6 promoter
	Search Chromatin IP Primers for FZD6
	RT² qPCR Primer Assay in human, mouse, rat FZD6
	Search GNC Networks for FZD6
	SABiosciences PCR Arrays including human, mouse, rat FZD6

Search Tocris compounds for FZD6

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	FZD6 antibodies
	FZD6 proteins
	FZD6 lysates

	Antibodies for FZD6
	See all of Abcam's Antibodies, Kits and Proteins for FZD6
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

FZD6 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for FZD6

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD6

	SwitchGear 3'UTR luciferase reporter plasmids for FZD6
	SwitchGear Promoter luciferase reporter plasmids for FZD6

ThermoFisher Antibodies for FZD6

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FZD6

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes FZD6 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

FZD6 Gene

frizzled family receptor 6

Aliases
for FZD6 gene

Summaries
for FZD6 gene

Genomic Views
for FZD6 gene

Proteins
for FZD6 gene

Protein Domains /
Families
for FZD6 gene

Function
for FZD6 gene

Pathways & Interactions
for FZD6 gene

Drugs & Compounds
for FZD6 gene

Transcripts
for FZD6 gene

Expression
for FZD6 gene

Orthologs
for FZD6 gene

Paralogs
for FZD6 gene

Genomic Variants
for FZD6 gene

Disorders / Diseases
for FZD6 gene

Publications
for FZD6 gene

External Searches for FZD6 gene

Genome Databases showing FZD6 gene

Other Databases showing FZD6 gene

Specialized Databases showing FZD6 gene

Intellectual Property
for FZD6 gene

Products
for FZD6 gene

View Random Gene

Advanced Search

Export list of displayed genes

FZD6 Gene

frizzled family receptor 6

Aliasesfor FZD6 gene

Summariesfor FZD6 gene

Genomic Viewsfor FZD6 gene

Proteinsfor FZD6 gene

Protein Domains /Familiesfor FZD6 gene

Functionfor FZD6 gene

Pathways & Interactionsfor FZD6 gene

Drugs & Compoundsfor FZD6 gene

Transcriptsfor FZD6 gene

Expression for FZD6 gene

Orthologsfor FZD6 gene

Paralogsfor FZD6 gene

Genomic Variantsfor FZD6 gene

Disorders / Diseasesfor FZD6 gene

Publicationsfor FZD6 gene

External Searches for FZD6 gene

Genome Databases showing FZD6 gene

Other Databases showing FZD6 gene

Specialized Databases showing FZD6 gene

Intellectual Propertyfor FZD6 gene

Productsfor FZD6 gene

View Random Gene

Aliases
for FZD6 gene

Summaries
for FZD6 gene

Genomic Views
for FZD6 gene

Proteins
for FZD6 gene

Protein Domains /
Families
for FZD6 gene

Function
for FZD6 gene

Pathways & Interactions
for FZD6 gene

Drugs & Compounds
for FZD6 gene

Transcripts
for FZD6 gene

Expression
for FZD6 gene

Orthologs
for FZD6 gene

Paralogs
for FZD6 gene

Genomic Variants
for FZD6 gene

Disorders / Diseases
for FZD6 gene

Publications
for FZD6 gene

Intellectual Property
for FZD6 gene

Products
for FZD6 gene