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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FZD6 Gene

protein-coding   GIFtS: 70
GCID: GC08P104267

Frizzled Family Receptor 6

(Previous names: frizzled (Drosophila) homolog 6, frizzled homolog 6 (Drosophila),...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Frizzled Family Receptor 61 2     NDNC102
Frizzled 6, Seven Transmembrane Spanning Receptor1 2     Frizzled Homolog 62
Frizzled (Drosophila) Homolog 61     frizzled-62
Frizzled Homolog 6 (Drosophila)1     Seven Transmembrane Helix Receptor2
FZ-62     Fz-63
FZ62     hFz63
HFZ62     

External Ids:    HGNC: 40441   Entrez Gene: 83232   Ensembl: ENSG000001649307   OMIM: 6034095   UniProtKB: O603533   

Export aliases for FZD6 gene to outside databases

Previous GC identifers: GC08P103316 GC08P104379 GC08P103979 GC08P099511


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FZD6 Gene:
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are
receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a
cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other
family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a
negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that
trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results
in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.(provided
by RefSeq, Aug 2011)

GeneCards Summary for FZD6 Gene: 
FZD6 (frizzled family receptor 6) is a protein-coding gene. Diseases associated with FZD6 include autosomal recessive nail dysplasia, and exudative vitreoretinopathy, and among its related super-pathways are Wnt signaling pathway and GPCR downstream signaling. GO annotations related to this gene include PDZ domain binding and G-protein coupled receptor activity. An important paralog of this gene is FZD3.

UniProtKB/Swiss-Prot: FZD6_HUMAN, O60353
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical
signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear
accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and
calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway
or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of
GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and
intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues

Gene Wiki entry for FZD6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FZD6 gene promoter:
         AML1a   HTF   STAT5A   LCR-F1   POU2F1   E2F-1   E2F   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFZD6 promoter sequence
   Search SABiosciences Chromatin IP Primers for FZD6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FZD6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.3-q23.1   Ensembl cytogenetic band:  8q22.3   HGNC cytogenetic band: 8q22.3-q23.1

FZD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZD6 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P104267:  view genomic region     (about GC identifiers)

Start:
104,310,661 bp from pter      End:
104,345,094 bp from pter
Size:
34,434 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FZD6_HUMAN, O60353 (See protein sequence)
Recommended Name: Frizzled-6 precursor  
Size: 706 amino acids; 79292 Da
Subcellular location: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By
similarity)
Secondary accessions: B4DRN0 Q6N0A5 Q6P9C3 Q8WXR9
Alternative splicing: 2 isoforms:  O60353-1   O60353-2   

Explore the universe of human proteins at neXtProt for FZD6: NX_O60353

Explore proteomics data for FZD6 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60353

  • FZD6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FZD6 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001158087.1  NP_001158088.1  NP_003497.2  

    ENSEMBL proteins: 
     ENSP00000429055   ENSP00000428301   ENSP00000428257   ENSP00000429528   ENSP00000427733  
     ENSP00000428188   ENSP00000351605   ENSP00000443757  
    Reactome Protein details: O60353
    Human Recombinant Protein Products for FZD6: 
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    Novus Biologicals FZD6 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FZD6 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005886plasma membrane IDA--
    GO:0005887integral to plasma membrane ISS15265686
    GO:0016020membrane ----
    GO:0016021integral to membrane ----

    FZD6 for ontologies           About GeneDecksing



    FZD6 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FZD: GPCR / Class F : Frizzled receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: FZD6 
    Frizzled Class GPCRs

    5 InterPro protein domains:
     IPR000539 Frizzled
     IPR026543 FZD6
     IPR020067 Frizzled_dom
     IPR015526 Frizzled/SFRP
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry O60353

    ProtoNet protein and cluster: O60353

    1 Blocks protein domain: IPB000539 Frizzled protein signature

    UniProtKB/Swiss-Prot: FZD6_HUMAN, O60353
    Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in
    the activation of the Wnt/beta-catenin signaling pathway (By similarity)
    Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
    Similarity: Belongs to the G-protein coupled receptor Fz/Smo family
    Similarity: Contains 1 FZ (frizzled) domain


    FZD6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FZD6_HUMAN, O60353
    Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical
    signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear
    accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and
    calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway
    or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of
    GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and
    intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues

         Genatlas biochemistry entry for FZD6:
    Drosophila frizzled polarity gene homolog,G protein coupled receptor superfamily,exhibiting characteristics of a
    WNT receptor,expressed in various normal adult and fetal tissues,involved in signal transduction,activating
    Dishevelled

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005515protein binding IPI10347172
    GO:0017147Wnt-protein binding ISS15265686
    GO:0030165PDZ domain binding IBA--
         
    FZD6 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Fzd6):
     embryogenesis  hearing/vestibular/ear  integument  limbs/digits/tail  mortality/aging 
     nervous system  normal  reproductive system  vision/eye 

    FZD6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fzd6tm1Lex for FZD6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FZD6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FZD6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FZD6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FZD6 

    miRNA
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    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate FZD6 (see all 39):
    hsa-miR-607 hsa-miR-302d hsa-miR-520e hsa-miR-15a hsa-miR-301a hsa-miR-519a hsa-miR-424 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidFZD6 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): FZD6 (NM_001164615)
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                         Customized lentivirus expression plasmids for stable overexpression of FZD6 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FZD6 About   (see all 22)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathway0.40
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    GSK3 Signaling0.61
    4Wnt Signaling Pathway
    Wnt Signaling Pathway0.55
    Wnt Signaling Pathway and Pluripotency0.55
    5Human Embryonic Stem Cell Pluripotency
    Human Embryonic Stem Cell Pluripotency0.50
    Factors Promoting Cardiogenesis in Vertebrates0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for FZD6
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 R&D Systems Pathway for FZD6
        Wnt Signaling Pathway

    5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FZD6 (see all 11)
        Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Colorectal Cancer Metastasis
    Glioblastoma Multiforme

    1 Cell Signaling Technology (CST) Pathway for FZD6
        Wnt / Hedgehog / Notch

    2 GeneGo (Thomson Reuters) Pathways for FZD6
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    4 BioSystems Pathways for FZD6
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway NetPath
    Wnt signaling network


    4        Reactome Pathways for FZD6
        Signal Transduction
    Signaling by GPCR
    GPCR ligand binding
    Class B/2 (Secretin family receptors)


    5/7         Kegg Pathways  (Kegg details for FZD6) (see all 7):
        Wnt signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection
    Pathways in cancer


    FZD6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FZD6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for FZD6 (O603533 ENSP000003516054) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WNT4P567053, ENSP000002901674I2D: score=2 STRING: ENSP00000290167
    SFRP1Q8N4743, ENSP000002207724I2D: score=2 STRING: ENSP00000220772
    CTHRC1ENSP000003305234STRING: ENSP00000330523
    DVL1ENSP000003681694STRING: ENSP00000368169
    DVL2ENSP000000053404STRING: ENSP00000005340
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IBA--
    GO:0001736establishment of planar polarity IBA--
    GO:0001843neural tube closure IBA--
    GO:0001942hair follicle development IEA--
    GO:0007166cell surface receptor signaling pathway ----

    FZD6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FZD6

    1 HMDB Compound for FZD6    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 IUPHAR Ligands for FZD6 (FZD6)    About this table 
    LigandTypeActionAffinityPubmed IDs
    Wnt-5a
    AgonistAgonist21665003
    Wnt-4
    AgonistAgonist21541287 15265686
    Wnt-3a
    AgonistAgonist21665003 21128903

    Search CenterWatch for drugs/clinical trials and news about FZD6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FZD6 gene (3 alternative transcripts): 
    NM_001164615.1  NM_001164616.1  NM_003506.3  

    Unigene Cluster for FZD6:

    Frizzled family receptor 6
    Hs.591863  [show with all ESTs]
    Unigene Representative Sequence: BX538222
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000522566(uc003ylh.3) ENST00000522484 ENST00000523933 ENST00000523739
    ENST00000519011 ENST00000521195 ENST00000358755(uc011lhn.2 uc003ylj.3 uc011lho.2 uc011lhp.2)
    ENST00000540287
    miRNA
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    Additional mRNA sequence: 

    AB012911.1 AB209734.1 AF072873.1 AK296824.1 AK299341.1 AK304092.1 AK313789.1 AK316544.1 
    BC036106.1 BC060836.1 BX538222.1 BX640609.1 

    12 DOTS entries:

    DT.95265004  DT.100687502  DT.313636  DT.101982634  DT.92043230  DT.99972645  DT.121479276  DT.121479296 
    DT.121479236  DT.121479264  DT.313638  DT.95265002 

    24/119 AceView cDNA sequences (see all 119):

    AU131025 CR623773 NM_003506 CD644741 AU131395 BU627239 BP351890 CA394506 
    AW148330 BX109942 AI220799 N57630 BC060836 AI250244 AU130927 BX479752 
    AI857747 CA311380 AW511572 BM770542 CA413718 CB854356 BG111793 AI625642 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FZD6    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
    SP1:                                                                        
    SP2:                                      -                                 
    SP3:        -     -                                                         


    ECgene alternative splicing isoforms for FZD6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FZD6 expression in normal human tissues (normalized intensities)      FZD6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCACCCATT
    FZD6 Expression
    About this image


    FZD6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Somite (Muscoskeletal System)    fully expand to see all 8 entries
             Muscle Progenitor Cells Cervical Dorsomedial Dermomyotome Lip
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 8 entries
             Muscle Progenitor Cells Cervical Dorsomedial Dermomyotome Lip
     
     Adipose (Muscoskeletal System)    fully expand to see all 4 entries
             Sacral Dermomyotome Cells Sacral Dermomyotome
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             mouse/organ system/cardiovascular system   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Midbrain tegmentum
             brain/midbrain   

    See FZD6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FZD6

    SOURCE GeneReport for Unigene cluster: Hs.591863

    UniProtKB/Swiss-Prot: FZD6_HUMAN, O60353
    Tissue specificity: Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas,
    thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and
    kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including FZD6: 
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              Stem Cell Signaling in human mouse rat
              Notch Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FZD6 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fzd61 , 5 frizzled homolog 6 (Drosophila)1, 5 83.43(n)1
    84.05(a)1
      15 (15.22 cM)5
    143681  NM_001162494.11  NP_001155966.11 
     390062805 
    chicken
    (Gallus gallus)
    Aves FZD61 frizzled family receptor 6 74(n)
    76.41(a)
      378788  XM_418372.3  XP_418372.3 
    lizard
    (Anolis carolinensis)
    Reptilia FZD66
    Uncharacterized protein
    71(a)
    1 ↔ 1
    4(13719089-13742527)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL857901.22   -- 73.01(n)    AL857901.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc658792 hypothetical protein MGC65879 73.56(n)   393533  BC056573.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fz6
    frizzled
    36(a)
    1 → many
    3L(14267443-14361739)
    worm
    (Caenorhabditis elegans)
    Secernentea mom-56
    Protein MOM-5
    30(a)
    1 → many
    I(9965588-9969413)


    ENSEMBL Gene Tree for FZD6 (if available)
    TreeFam Gene Tree for FZD6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FZD6 gene
    FZD32  FZD102  FZD82  FZD12  FZD52  FZD22  FZD92  SFRP42  
    SMO2  FZD42  SFRP12  FRZB2  SFRP52  FZD72  SFRP22  
    11 SIMAP similar genes for FZD6 using alignment to 6 protein entries:     FZD6_HUMAN (see all proteins):
    GPCR    FZD3    FZD1    FZD2    FZD7    FZD10
    FZD9    SMO    FZD4    FZD5    FRZB

    FZD6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/753 SNPs in FZD6 are shown (see all 753)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0663984
    Nail disorder, non-syndromic congenital, 10 (NDNC10)4--see VAR_0663982 R C mis40--------
    VAR_0669674
    ----see VAR_0669672 R H mis40--------
    rs2014075801,2
    C--99533875(+) TTTTTA/TAAAGG 3 -- int10--------
    rs778270181,2
    C--99542694(+) TTGCCTTT/-TTAAT 3 -- cds11Minor allele frequency- -:0.00CSA 2
    rs339517531,2
    C--99544475(+) AAAAA-/TTTTGT 3 -- int10--------
    rs358993221,2
    C--104314266(+) TGAAG-/TTTTTT 3 -- int12Minor allele frequency- T:0.00NA CSA 4
    rs58936471,2
    C--104316154(+) GTCAG-/T/TT  
            
    TTTTT
    3 -- int11NA 2
    rs352009221,2
    C--104316154(+) GTCAG-/TTTTTTT 3 -- int10--------
    rs712927931,2
    C--104318723(+) TTTTT-/TGAGAC 3 -- int12Minor allele frequency- T:0.25NA 4
    rs105824591,2
    C--104319528(+) TATCA-/TATTATTA 3 -- int10--------

    HapMap Linkage Disequilibrium report for FZD6 (104310661 - 104345094 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FZD6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv523544CNV Loss19592680
    nsv527031CNV Loss19592680


    Human Gene Mutation Database (HGMD): FZD6
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603409    OMIM disorders: --

    UniProtKB/Swiss-Prot: FZD6_HUMAN, O60353
  • Nail disorder, non-syndromic congenital, 10 (NDNC10) [MIM:614157]: A nail disorder characterized by a
    variable degree of onychauxis (thick nails), hyponychia, and onycholysis of all nails, with claw-shaped
    fingernails in some individuals. No other anomalies of ectodermal tissues, including hair, teeth, sweat glands,
    or skin, are noted, and individuals with dysplastic nails have normal hearing and normal psychomotor development.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Note=Rare non-synonymous variants in FZD6 may contribute to neural tube defects, congenital malformations
    of the central nervous system and adjacent structures related to defective neural tube closure during the first
    trimester of pregnancy

  • 16 diseases for FZD6:    About MalaCards
    autosomal recessive nail dysplasia    exudative vitreoretinopathy    strabismus    hyperopia
    neural tube defects    basal cell carcinoma    pituitary adenoma    acute leukemia
    adenoma    glioblastoma    colorectal cancer    neuroblastoma
    leukemia    breast cancer    neuronitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for FZD6:
    Hyperopia

    FZD6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FZD6
    Human Genome Epidemiology (HuGE) Navigator: FZD6 (4 documents)
    Tumor Gene Database (TGDB): FZD6

    Export disorders for FZD6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FZD6 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with FZD6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of human frizzled-6. (PubMed id 9480858)1, 2, 3, 9 Tokuhara M.... Katoh M. (1998)
    2. FZD6 is a novel gene for human neural tube defects. (PubMed id 22045688)1, 2 De Marco P....Capra V. (2011)
    3. Mutations in Frizzled 6 cause isolated autosomal-recessive nail dysplasia. (PubMed id 21665003)1, 2 Frojmark A.S.... Dahl N. (2011)
    4. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    5. Non-association between polymorphisms of the frizzled receptor genes and bone mineral density in postmenopausal Korean women. (PubMed id 19543507)1, 4 Kim J.G....Moon S.Y. (2009)
    6. The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade. (PubMed id 14747478)1, 3 Golan T....Gazit A. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. A novel missense mutation in the gene FZD6 underlies a utosomal recessive nail dysplasia. (PubMed id 22861124)1 Raza S.I....Ahmad W. (2013)
    9. FZD6 encoding the Wnt receptor frizzled 6 is mutated i n autosomal-recessive nail dysplasia. (PubMed id 22211385)1 Naz G....Betz R.C. (2012)
    10. ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. (PubMed id 22575959)2 Hao H.X....Cong F. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8323 HGNC: 4044 AceView: FZD6 Ensembl:ENSG00000164930 euGenes: HUgn8323
    ECgene: FZD6 Kegg: 8323 H-InvDB: FZD6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FZD6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FZD6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FZD6 gene:
    Search GeneIP for patents involving FZD6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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