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FZD6 Gene

protein-coding   GIFtS: 71
GCID: GC08P104267

Frizzled Class Receptor 6

(Previous names: frizzled (Drosophila) homolog 6, frizzled homolog 6 (Drosophila),...)
  See FZD6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Frizzled Class Receptor 61 2     FZ62
Frizzled 6, Seven Transmembrane Spanning Receptor1 2     HFZ62
Frizzled Family Receptor 61 2     Frizzled Homolog 62
NDNC102 5     frizzled-62
Frizzled (Drosophila) Homolog 61     Seven Transmembrane Helix Receptor2
Frizzled Homolog 6 (Drosophila)1     Fz-63
FZ-62     hFz63

External Ids:    HGNC: 40441   Entrez Gene: 83232   Ensembl: ENSG000001649307   OMIM: 6034095   UniProtKB: O603533   

Export aliases for FZD6 gene to outside databases

Previous GC identifers: GC08P103316 GC08P104379 GC08P103979 GC08P099511


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FZD6 Gene:
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are
receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a
cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other
family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a
negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that
trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results
in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.(provided
by RefSeq, Aug 2011)

GeneCards Summary for FZD6 Gene:
FZD6 (frizzled class receptor 6) is a protein-coding gene. Diseases associated with FZD6 include nail disorder, nonsyndromic congenital, 10,, and osteoblastoma. GO annotations related to this gene include PDZ domain binding and G-protein coupled receptor activity. An important paralog of this gene is FZD3.

UniProtKB/Swiss-Prot: FZD6_HUMAN, O60353
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical
signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear
accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and
calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway
or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of
GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and
intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues

Gene Wiki entry for FZD6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FZD6 gene promoter:
         AML1a   HTF   STAT5A   LCR-F1   POU2F1   E2F-1   E2F   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFZD6 promoter sequence
   Search Chromatin IP Primers for FZD6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FZD6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.3-q23.1   Ensembl cytogenetic band:  8q22.3   HGNC cytogenetic band: 8q22.3-q23.1

FZD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZD6 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P104267:  view genomic region     (about GC identifiers)

Start:
104,310,661 bp from pter      End:
104,345,094 bp from pter
Size:
34,434 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FZD6_HUMAN, O60353 (See protein sequence)
Recommended Name: Frizzled-6 precursor  
Size: 706 amino acids; 79292 Da
Secondary accessions: B4DRN0 Q6N0A5 Q6P9C3 Q8WXR9
Alternative splicing: 2 isoforms:  O60353-1   O60353-2   

Explore the universe of human proteins at neXtProt for FZD6: NX_O60353

Explore proteomics data for FZD6 at MOPED

Post-translational modifications: 

  • Ubiquitinated by ZNRF3, leading to its degradation by the proteasome (By similarity)1
  • Glycosylation2 at Asn38, Thr150, Asn352
  • Modification sites at PhosphoSitePlus

  • See FZD6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001158087.1  NP_001158088.1  NP_003497.2  

    ENSEMBL proteins: 
     ENSP00000429055   ENSP00000428301   ENSP00000428257   ENSP00000429528   ENSP00000427733  
     ENSP00000428188   ENSP00000351605   ENSP00000443757  
    Reactome Protein details: O60353

    FZD6 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for FZD6
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    Novus Biologicals FZD6 Protein
    Novus Biologicals FZD6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FZD6

     
    Search eBioscience for Proteins for FZD6 

     
    antibodies-online proteins for FZD6 (2 products) 

     
    antibodies-online peptides for FZD6

    FZD6 Antibody Products:

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    FZD6 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FZD6
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    antibodies-online kits for FZD6 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FZD: GPCR / Class F : Frizzled receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: FZD6
    Frizzled Class GPCRs

    5 InterPro protein domains:
     IPR000539 Frizzled
     IPR026543 FZD6
     IPR020067 Frizzled_dom
     IPR015526 Frizzled/SFRP
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry O60353

    ProtoNet protein and cluster: O60353

    1 Blocks protein domain: IPB000539 Frizzled protein signature

    UniProtKB/Swiss-Prot: FZD6_HUMAN, O60353
    Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in
    the activation of the Wnt/beta-catenin signaling pathway (By similarity)
    Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
    Similarity: Belongs to the G-protein coupled receptor Fz/Smo family
    Similarity: Contains 1 FZ (frizzled) domain


    Find genes that share domains with FZD6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FZD6_HUMAN, O60353
    Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical
    signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear
    accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and
    calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway
    or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of
    GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and
    intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues

         Genatlas biochemistry entry for FZD6:
    Drosophila frizzled polarity gene homolog,G protein coupled receptor superfamily,exhibiting characteristics of a
    WNT receptor,expressed in various normal adult and fetal tissues,involved in signal transduction,activating
    Dishevelled

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005515protein binding IPI10347172
    GO:0017147Wnt-protein binding ISS15265686
    GO:0030165PDZ domain binding IBA--
         
    Find genes that share ontologies with FZD6           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Fzd6):
     embryogenesis  hearing/vestibular/ear  integument  limbs/digits/tail  mortality/aging 
     nervous system  normal  reproductive system  vision/eye 

    Find genes that share phenotypes with FZD6           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FZD6

    miRNA
    Products:
        
    miRTarBase miRNAs that target FZD6:
    hsa-mir-101-3p (MIRT027324)

    Block miRNA regulation of human, mouse, rat FZD6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FZD6 (see all 39):
    hsa-miR-607 hsa-miR-302d hsa-miR-520e hsa-miR-15a hsa-miR-301a hsa-miR-519a hsa-miR-424 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidFZD6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FZD6
    Predesigned siRNA for gene silencing in human, mouse, rat FZD6

    Gene Editing
    Products:
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    Clone
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    OriGene clones in human, mouse for FZD6 (see all 17)
    OriGene ORF clones in mouse, rat for FZD6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FZD6 (NM_001164615)
    Sino Biological Human cDNA Clone for FZD6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FZD6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FZD6

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for FZD6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FZD6_HUMAN, O60353: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane ISS15265686
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with FZD6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FZD6 About   (see all 24)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    2beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Ca2+ pathway0.43
    Signaling by Wnt0.79
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    GSK3 Signaling0.61
    5Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    Wnt Signaling Pathway and Pluripotency0.55


    Find genes that share SuperPaths with FZD6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for FZD6
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FZD6 (see all 11)
        Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Colorectal Cancer Metastasis
    Glioblastoma Multiforme

    1 Cell Signaling Technology (CST) Pathway for FZD6
        Wnt / Hedgehog / Notch

    2 GeneGo (Thomson Reuters) Pathways for FZD6
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    4 BioSystems Pathways for FZD6
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway NetPath
    Wnt signaling network


    4 Reactome Pathways for FZD6
        regulation of FZD by ubiquitination
    PCP/CE pathway
    Ca2+ pathway
    Class B/2 (Secretin family receptors)


    Selected Kegg Pathways  (Kegg details for FZD6) (see all 7):
        Wnt signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection
    Pathways in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FZD6: 
              G Protein Coupled Receptors 384HT in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FZD6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FZD6 (O603531, 3 ENSP000003516054) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFRP1Q8N4741, 3, ENSP000002207724EBI-8754490,EBI-3940687 I2D: score=2 STRING: ENSP00000220772
    WNT4P567053, ENSP000002901674I2D: score=2 STRING: ENSP00000290167
    CTHRC1ENSP000003305234STRING: ENSP00000330523
    DVL1ENSP000003681694STRING: ENSP00000368169
    DVL2ENSP000000053404STRING: ENSP00000005340
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IBA--
    GO:0001736establishment of planar polarity IBA--
    GO:0001843neural tube closure IBA--
    GO:0001942hair follicle development IEA--
    GO:0007166cell surface receptor signaling pathway ----

    Find genes that share ontologies with FZD6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FZD6

    1 HMDB Compound for FZD6    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 IUPHAR Ligands for FZD6 (FZD6)    About this table
    LigandTypeActionAffinityPubmed IDs
    Wnt-5a
    AgonistAgonist21665003
    Wnt-4
    AgonistAgonist21541287 15265686
    Wnt-3a
    AgonistAgonist21665003 21128903



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FZD6 gene (3 alternative transcripts): 
    NM_001164615.1  NM_001164616.1  NM_003506.3  

    Unigene Cluster for FZD6:

    Frizzled family receptor 6
    Hs.591863  [show with all ESTs]
    Unigene Representative Sequence: BX538222
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000522566(uc003ylh.3) ENST00000522484 ENST00000523933 ENST00000523739
    ENST00000519011 ENST00000521195 ENST00000358755(uc011lhn.2 uc003ylj.3 uc011lho.2 uc011lhp.2)
    ENST00000540287
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FZD6 (see all 39):
    hsa-miR-607 hsa-miR-302d hsa-miR-520e hsa-miR-15a hsa-miR-301a hsa-miR-519a hsa-miR-424 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidFZD6 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FZD6
      QuantiTect SYBR Green Assays in human, mouse, rat FZD6
      QuantiFast Probe-based Assays in human, mouse, rat FZD6

    Additional mRNA sequence: 

    AB012911.1 AB209734.1 AF072873.1 AK296824.1 AK299341.1 AK304092.1 AK313789.1 AK316544.1 
    BC036106.1 BC060836.1 BX538222.1 BX640609.1 

    12 DOTS entries:

    DT.95265004  DT.100687502  DT.313636  DT.101982634  DT.92043230  DT.99972645  DT.121479276  DT.121479296 
    DT.121479236  DT.121479264  DT.313638  DT.95265002 

    Selected AceView cDNA sequences (see all 119):

    CD644741 BP351890 AI220799 BX109942 AW148330 N57630 AU131395 NM_003506 
    CR623773 BU627239 CA394506 AU131025 BX329173 CA454410 D63299 CB854356 
    BX479752 AB012911 CA311380 BG284542 AA319328 BX641781 AI250244 BM976597 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FZD6    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
    SP1:                                                                        
    SP2:                                      -                                 
    SP3:        -     -                                                         


    ECgene alternative splicing isoforms for FZD6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    FZD6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCACCCATT
    FZD6 Expression
    About this image


    FZD6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Liver Bud
             Liver Bud
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Thymus (Hematopoietic System)
             Thymus
     
     NULL (Uncategorized)
             Endothelial cells and neural cells
    FZD6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FZD6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591863

    UniProtKB/Swiss-Prot: FZD6_HUMAN, O60353
    Tissue specificity: Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas,
    thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and
    kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FZD6: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FZD6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fzd61 , 5 frizzled homolog 6 (Drosophila)1, 5 83.4(n)1
    83.93(a)1
      15 (15.22 cM)5
    143681  NM_001162494.11  NP_001155966.11 
     390062805 
    chicken
    (Gallus gallus)
    Aves FZD61 frizzled family receptor 6 74.05(n)
    76.41(a)
      378788  NM_001271931.1  NP_001258860.1 
    lizard
    (Anolis carolinensis)
    Reptilia FZD66
    frizzled family receptor 6
    71(a)
    1 ↔ 1
    4(13719089-13742527)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL857901.22   -- 73.01(n)    AL857901.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc658792 hypothetical protein MGC65879 73.56(n)   393533  BC056573.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fz6
    frizzled
    37(a)
    1 → many
    3L(14267443-14361739)


    ENSEMBL Gene Tree for FZD6 (if available)
    TreeFam Gene Tree for FZD6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FZD6 gene
    FZD32  FZD102  FZD82  FZD12  FZD52  FZD22  FZD92  SFRP42  
    SMO2  FZD42  SFRP12  FRZB2  SFRP52  FZD72  SFRP22  
    11 SIMAP similar genes for FZD6 using alignment to 6 protein entries:     FZD6_HUMAN (see all proteins):
    GPCR    FZD3    FZD1    FZD2    FZD7    FZD10
    FZD9    SMO    FZD4    FZD5    FRZB

    Find genes that share paralogs with FZD6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FZD6 (see all 753)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0663984
    Nail disorder, non-syndromic congenital, 10 (NDNC10)4--see VAR_0663982 R C mis40--------
    rs2014075801,2
    C--99533875(+) TTTTTA/TAAAGG 3 -- int10--------
    rs778270181,2
    C--99542694(+) TTGCCTTT/-TTAAT 3 -- cds11Minor allele frequency- -:0.00CSA 2
    rs339517531,2
    C--99544475(+) AAAAA-/TTTTGT 3 -- int10--------
    rs358993221,2
    C--104314266(+) TGAAG-/TTTTTT 3 -- int12Minor allele frequency- T:0.00NA CSA 4
    rs58936471,2
    C--104316154(+) GTCAG-/T/TT  
            
    TTTTT
    3 -- int11NA 2
    rs352009221,2
    C--104316154(+) GTCAG-/TTTTTTT 3 -- int10--------
    rs712927931,2
    C--104318723(+) TTTTT-/TGAGAC 3 -- int12Minor allele frequency- T:0.25NA 4
    rs105824591,2
    C--104319528(+) TATCA-/TATTATTA 3 -- int10--------
    rs113128081,2
    C--104319948(+) GTGTG-/TTTTTT 3 -- int1 trp30--------

    HapMap Linkage Disequilibrium report for FZD6 (104310661 - 104345094 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FZD6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv523544CNV Loss19592680
    nsv527031CNV Loss19592680

    Human Gene Mutation Database (HGMD): FZD6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FZD6
    DNA2.0 Custom Variant and Variant Library Synthesis for FZD6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603409   
    OMIM disorders: 614157  
    UniProtKB/Swiss-Prot: FZD6_HUMAN, O60353
  • Nail disorder, non-syndromic congenital, 10 (NDNC10) [MIM:614157]: A nail disorder characterized by a
    variable degree of onychauxis (thick nails), hyponychia, and onycholysis of all nails, with claw-shaped
    fingernails in some individuals. No other anomalies of ectodermal tissues, including hair, teeth, sweat glands,
    or skin, are noted, and individuals with dysplastic nails have normal hearing and normal psychomotor development.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Note=Rare non-synonymous variants in FZD6 may contribute to neural tube defects, congenital malformations
    of the central nervous system and adjacent structures related to defective neural tube closure during the first
    trimester of pregnancy

  • 4 diseases for FZD6:    
    About MalaCards
    nail disorder, nonsyndromic congenital, 10,    osteoblastoma    exudative vitreoretinopathy    pachyonychia congenita

    1 disease from the University of Copenhagen DISEASES database for FZD6:
    Hyperopia

    Find genes that share disorders with FZD6           About GenesLikeMe

    Genetic Association Database (GAD): FZD6
    Human Genome Epidemiology (HuGE) Navigator: FZD6 (4 documents)
    Tumor Gene Database (TGDB): FZD6

    Export disorders for FZD6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FZD6 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with FZD6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of human frizzled-6. (PubMed id 9480858)1, 2, 3, 9 Tokuhara M.... Katoh M. (Biochem. Biophys. Res. Commun. 1998)
    2. FZD6 is a novel gene for human neural tube defects. (PubMed id 22045688)1, 2 De Marco P....Capra V. (Hum. Mutat. 2012)
    3. Mutations in Frizzled 6 cause isolated autosomal-recessive nail dysplasia. (PubMed id 21665003)1, 2 Frojmark A.S.... Dahl N. (Am. J. Hum. Genet. 2011)
    4. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    5. Non-association between polymorphisms of the frizzled receptor genes and bone mineral density in postmenopausal Korean women. (PubMed id 19543507)1, 4 Kim J.G....Moon S.Y. (J. Korean Med. Sci. 2009)
    6. The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade. (PubMed id 14747478)1, 3 Golan T....Gazit A. (J. Biol. Chem. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A novel missense mutation in the gene FZD6 underlies autosomal recessive nail dysplasia. (PubMed id 22861124)1 Raza S.I....Ahmad W. (Br. J. Dermatol. 2013)
    9. Recessive mutations in the gene encoding frizzled 6 cause twenty nail dystrophy--expanding the differential diagnosis for pachyonychia congenita. (PubMed id 23374899)1 Wilson N.J....Smith F.J. (J. Dermatol. Sci. 2013)
    10. FZD6 encoding the Wnt receptor frizzled 6 is mutated in autosomal-recessive nail dysplasia. (PubMed id 22211385)1 Naz G....Betz R.C. (Br. J. Dermatol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8323 HGNC: 4044 AceView: FZD6 Ensembl:ENSG00000164930 euGenes: HUgn8323
    ECgene: FZD6 Kegg: 8323 H-InvDB: FZD6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FZD6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FZD6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FZD6 gene:
    Search GeneIP for patents involving FZD6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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