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Aliases for FZD6 Gene

Aliases for FZD6 Gene

  • Frizzled Class Receptor 6 2 3
  • Frizzled 6, Seven Transmembrane Spanning Receptor 2 3
  • Frizzled Family Receptor 6 2 3
  • NDNC10 3 6
  • FZ-6 3 4
  • HFZ6 3 4
  • Seven Transmembrane Helix Receptor 3
  • Frizzled (Drosophila) Homolog 6 2
  • Frizzled Homolog 6 (Drosophila) 2
  • Frizzled Homolog 6 3
  • Frizzled-6 3
  • FZ6 3

External Ids for FZD6 Gene

Previous GeneCards Identifiers for FZD6 Gene

  • GC08P104379
  • GC08P103979
  • GC08P104267
  • GC08P099511

Summaries for FZD6 Gene

Entrez Gene Summary for FZD6 Gene

  • This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]

GeneCards Summary for FZD6 Gene

FZD6 (Frizzled Class Receptor 6) is a Protein Coding gene. Diseases associated with FZD6 include nail disorder, nonsyndromic congenital, 10, and autosomal recessive nail dysplasia. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include G-protein coupled receptor activity and PDZ domain binding. An important paralog of this gene is FZD10.

UniProtKB/Swiss-Prot for FZD6 Gene

  • Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity).

Gene Wiki entry for FZD6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FZD6 Gene

Genomics for FZD6 Gene

Regulatory Elements for FZD6 Gene

Genomic Location for FZD6 Gene

Start:
103,298,433 bp from pter
End:
103,332,866 bp from pter
Size:
34,434 bases
Orientation:
Plus strand

Genomic View for FZD6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FZD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FZD6 Gene

Proteins for FZD6 Gene

  • Protein details for FZD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60353-FZD6_HUMAN
    Recommended name:
    Frizzled-6
    Protein Accession:
    O60353
    Secondary Accessions:
    • B4DRN0
    • Q6N0A5
    • Q6P9C3
    • Q8WXR9

    Protein attributes for FZD6 Gene

    Size:
    706 amino acids
    Molecular mass:
    79292 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FZD6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FZD6 Gene

Proteomics data for FZD6 Gene at MOPED

Post-translational modifications for FZD6 Gene

  • Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
  • Glycosylation at Asn38, Thr150, and Asn352
  • Modification sites at PhosphoSitePlus

Other Protein References for FZD6 Gene

No data available for DME Specific Peptides for FZD6 Gene

Domains for FZD6 Gene

Gene Families for FZD6 Gene

HGNC:
  • FZD :GPCR / Class F : Frizzled receptors
IUPHAR :

Protein Domains for FZD6 Gene

Suggested Antigen Peptide Sequences for FZD6 Gene

Graphical View of Domain Structure for InterPro Entry

O60353

UniProtKB/Swiss-Prot:

FZD6_HUMAN :
  • O60353
Domain:
  • Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
  • The FZ domain is involved in binding with Wnt ligands.
  • Contains 1 FZ (frizzled) domain.
Family:
  • Belongs to the G-protein coupled receptor Fz/Smo family.
genes like me logo Genes that share domains with FZD6: view

Function for FZD6 Gene

Molecular function for FZD6 Gene

GENATLAS Biochemistry: Drosophila frizzled polarity gene homolog,G protein coupled receptor superfamily,exhibiting characteristics of a WNT receptor,expressed in various normal adult and fetal tissues,involved in signal transduction,activating Dishevelled
UniProtKB/Swiss-Prot Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity).

Gene Ontology (GO) - Molecular Function for FZD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity IBA --
GO:0005515 protein binding IPI 10347172
GO:0017147 Wnt-protein binding ISS 15265686
GO:0030165 PDZ domain binding --
genes like me logo Genes that share ontologies with FZD6: view
genes like me logo Genes that share phenotypes with FZD6: view

miRNA for FZD6 Gene

miRTarBase miRNAs that target FZD6

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FZD6 Gene

Localization for FZD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FZD6 Gene

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell surface. Apical cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Colocalizes with FZD3 at the apical face of cells (By similarity). {ECO:0000250 UniProtKB:Q61089}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FZD6 Gene COMPARTMENTS Subcellular localization image for FZD6 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for FZD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS 15265686
GO:0009986 cell surface IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with FZD6: view

Pathways for FZD6 Gene

genes like me logo Genes that share pathways with FZD6: view

Gene Ontology (GO) - Biological Process for FZD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis --
GO:0001736 establishment of planar polarity IEA --
GO:0001843 neural tube closure IEA --
GO:0001942 hair follicle development IEA --
GO:0007166 cell surface receptor signaling pathway --
genes like me logo Genes that share ontologies with FZD6: view

Compounds for FZD6 Gene

(1) HMDB Compounds for FZD6 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(3) IUPHAR Ligand for FZD6 Gene

Ligand Type Action Affinity Pubmed IDs
Wnt-5a Agonist Agonist
Wnt-4 Agonist Agonist
Wnt-3a Agonist Agonist
genes like me logo Genes that share compounds with FZD6: view

Transcripts for FZD6 Gene

Unigene Clusters for FZD6 Gene

Frizzled family receptor 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FZD6 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1:
SP2: -
SP3: - -

Relevant External Links for FZD6 Gene

GeneLoc Exon Structure for
FZD6
ECgene alternative splicing isoforms for
FZD6

Expression for FZD6 Gene

mRNA expression in normal human tissues for FZD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FZD6 Gene

SOURCE GeneReport for Unigene cluster for FZD6 Gene Hs.591863

mRNA Expression by UniProt/SwissProt for FZD6 Gene

O60353-FZD6_HUMAN
Tissue specificity: Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney
genes like me logo Genes that share expressions with FZD6: view

No data available for mRNA differential expression in normal tissues for FZD6 Gene

Orthologs for FZD6 Gene

This gene was present in the common ancestor of animals.

Orthologs for FZD6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FZD6 35
  • 99.58 (n)
  • 99.29 (a)
FZD6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FZD6 35
  • 90.56 (n)
  • 90.79 (a)
FZD6 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FZD6 35
  • 91.22 (n)
  • 92.78 (a)
FZD6 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fzd6 35
  • 83.4 (n)
  • 83.93 (a)
Fzd6 16
Fzd6 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FZD6 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FZD6 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fzd6 35
  • 84.37 (n)
  • 85.8 (a)
chicken
(Gallus gallus)
Aves FZD6 35
  • 74.05 (n)
  • 76.41 (a)
FZD6 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FZD6 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fzd6 35
  • 69.36 (n)
  • 71.33 (a)
zebrafish
(Danio rerio)
Actinopterygii fzd6 35
  • 54.91 (n)
  • 56.19 (a)
fzd6 36
  • 55 (a)
OneToOne
zgc65879 35
fruit fly
(Drosophila melanogaster)
Insecta fz 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4359 36
  • 32 (a)
OneToMany
Species with no ortholog for FZD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FZD6 Gene

ENSEMBL:
Gene Tree for FZD6 (if available)
TreeFam:
Gene Tree for FZD6 (if available)

Paralogs for FZD6 Gene

Paralogs for FZD6 Gene

Selected SIMAP similar genes for FZD6 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FZD6: view

Variants for FZD6 Gene

Sequence variations from dbSNP and Humsavar for FZD6 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs703808 -- 103,308,700(-) AGATA(C/T)GGGAA intron-variant
rs703809 -- 103,309,085(-) GCACA(C/T)CAAAG intron-variant
rs703810 -- 103,321,610(-) ATGCC(A/G)TAACC intron-variant
rs827524 -- 103,298,160(+) TAACC(A/G)TCATT upstream-variant-2KB
rs827525 -- 103,299,248(+) CAGGT(G/T)CCCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FZD6 Gene

Variant ID Type Subtype PubMed ID
nsv527031 CNV Loss 19592680
nsv523544 CNV Loss 19592680

Relevant External Links for FZD6 Gene

HapMap Linkage Disequilibrium report
FZD6
Human Gene Mutation Database (HGMD)
FZD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FZD6 Gene

Disorders for FZD6 Gene

(1) OMIM Diseases for FZD6 Gene (603409)

UniProtKB/Swiss-Prot

FZD6_HUMAN
  • Nail disorder, non-syndromic congenital, 10 (NDNC10) [MIM:614157]: A nail disorder characterized by a variable degree of onychauxis (thick nails), hyponychia, and onycholysis of all nails, with claw-shaped fingernails in some individuals. No other anomalies of ectodermal tissues, including hair, teeth, sweat glands, or skin, are noted, and individuals with dysplastic nails have normal hearing and normal psychomotor development. {ECO:0000269 PubMed:21665003}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=Rare non-synonymous variants in FZD6 may contribute to neural tube defects, congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy.

(1) University of Copenhagen DISEASES for FZD6 Gene

Relevant External Links for FZD6

Genetic Association Database (GAD)
FZD6
Human Genome Epidemiology (HuGE) Navigator
FZD6
Tumor Gene Database (TGDB):
FZD6
genes like me logo Genes that share disorders with FZD6: view

Publications for FZD6 Gene

  1. Molecular cloning of human frizzled-6. (PMID: 9480858) Tokuhara M. … Katoh M. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade. (PMID: 14747478) Golan T. … Gazit A. (J. Biol. Chem. 2004) 2 3
  4. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 48
  5. Non-association between polymorphisms of the frizzled receptor genes and bone mineral density in postmenopausal Korean women. (PMID: 19543507) Kim J.G. … Moon S.Y. (J. Korean Med. Sci. 2009) 3 48

Products for FZD6 Gene

Sources for FZD6 Gene

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