Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FZD5 Gene

protein-coding   GIFtS: 67
GCID: GC02M208628

Frizzled Class Receptor 5

(Previous names: frizzled (Drosophila) homolog 5, chromosome 2 open reading...)
(Previous symbol: C2orf31)
  See FZD5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Frizzled Class Receptor 51 2     frizzled-52
C2orf311 2 3     fz-52
Frizzled 5, Seven Transmembrane Spanning Receptor1 2     fzE52
Frizzled Family Receptor 51 2     Seven-Transmembrane Receptor Frizzled-52
Chromosome 2 Open Reading Frame 311     Wnt Receptor2
Frizzled (Drosophila) Homolog 51     Fz-53
Frizzled Homolog 5 (Drosophila)1     FzE53
HFZ52     hFz53

External Ids:    HGNC: 40431   Entrez Gene: 78552   Ensembl: ENSG000001632517   OMIM: 6017235   UniProtKB: Q134673   

Export aliases for FZD5 gene to outside databases

Previous GC identifers: GC02M206847 GC02M207355 GC02M208594 GC02M208833 GC02M208456 GC02M208338 GC02M200469


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FZD5 Gene:
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling
proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. (provided by RefSeq, Jul 2008)

GeneCards Summary for FZD5 Gene:
FZD5 (frizzled class receptor 5) is a protein-coding gene. Diseases associated with FZD5 include exudative vitreoretinopathy. GO annotations related to this gene include G-protein coupled receptor activity and ubiquitin protein ligase binding. An important paralog of this gene is FZD3.

UniProtKB/Swiss-Prot: FZD5_HUMAN, Q13467
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical
signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear
accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and
calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway
or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of
GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and
intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Interacts specifically with Wnt5A to induce the beta-catenin pathway

Gene Wiki entry for FZD5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the FZD5 gene promoter:
         E2F-4   E2F-3a   E2F-5   Pax-5   E2F-2   E47   CREB   HEN1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFZD5 promoter sequence
   Search Chromatin IP Primers for FZD5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FZD5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.3   Ensembl cytogenetic band:  2q33.3   HGNC cytogenetic band: 2q33.3

FZD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZD5 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M208628:  view genomic region     (about GC identifiers)

Start:
208,627,310 bp from pter      End:
208,634,287 bp from pter
Size:
6,978 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FZD5_HUMAN, Q13467 (See protein sequence)
Recommended Name: Frizzled-5 precursor  
Size: 585 amino acids; 64507 Da
Subunit: Interacts with GOPC (By similarity)
Secondary accessions: Q53R22

Explore the universe of human proteins at neXtProt for FZD5: NX_Q13467

Explore proteomics data for FZD5 at MOPED

Post-translational modifications: 

  • Ubiquitinated by RNF43 and ZNRF3, leading to its degradation by the proteasome1
  • Glycosylation2 at Asn47, Asn151
  • Modification sites at PhosphoSitePlus

  • See FZD5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003459.2  
    ENSEMBL proteins: 
     ENSP00000354607  
    Reactome Protein details: Q13467

    FZD5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FZD5 (Frizzled-5)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FZD5
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FZD5
    GenScript Custom Purified and Recombinant Proteins Services for FZD5
    Novus Biologicals FZD5 Proteins
    Novus Biologicals FZD5 Lysates
    Sino Biological Recombinant Protein for FZD5
    Sino Biological Cell Lysate for FZD5
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FZD5

     
    Search eBioscience for Proteins for FZD5 

     
    antibodies-online proteins for FZD5 (4 products) 

     
    antibodies-online peptides for FZD5

    FZD5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FZD5
    R&D Systems Antibodies for FZD5 (Frizzled-5)
    Cell Signaling Technology (CST) Antibodies for FZD5 
    OriGene Antibodies for FZD5
    OriGene Custom Antibody Services for FZD5
    Novus Biologicals FZD5 Antibodies
    Abcam antibodies for FZD5
    Cloud-Clone Corp. Antibodies for FZD5
    ThermoFisher Antibody for FZD5
    LSBio Antibodies in human, mouse, rat for FZD5
    antibodies-online antibodies for FZD5 (74 products) 

    FZD5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FZD5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FZD5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FZD5
    Cloud-Clone Corp. CLIAs for FZD5
    Search eBioscience for ELISAs for FZD5 
    antibodies-online kits for FZD5 (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    FZD: GPCR / Class F : Frizzled receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: FZD5
    Frizzled Class GPCRs

    5 InterPro protein domains:
     IPR000539 Frizzled
     IPR020067 Frizzled_dom
     IPR015526 Frizzled/SFRP
     IPR017981 GPCR_2-like
     IPR026547 FZD5/FZD8

    Graphical View of Domain Structure for InterPro Entry Q13467

    ProtoNet protein and cluster: Q13467

    1 Blocks protein domain: IPB000539 Frizzled protein signature

    UniProtKB/Swiss-Prot: FZD5_HUMAN, Q13467
    Domain: The PDZ-binding motif mediates interaction with GOPC (By similarity)
    Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in
    the activation of the Wnt/beta-catenin signaling pathway (By similarity)
    Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
    Similarity: Belongs to the G-protein coupled receptor Fz/Smo family
    Similarity: Contains 1 FZ (frizzled) domain


    Find genes that share domains with FZD5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FZD5_HUMAN, Q13467
    Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical
    signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear
    accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and
    calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway
    or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of
    GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and
    intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
    Interacts specifically with Wnt5A to induce the beta-catenin pathway

         Genatlas biochemistry entry for FZD5:
    Drosophila frizzled polarity gene homolog 5,G protein coupled receptor superfamily,exhibiting characteristics of a
    WNT receptor,(WNT5A,at least in Xenopus),involved in signal transduction,activating Dishevelled

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005515protein binding IPI18838381
    GO:0017147Wnt-protein binding IPI12490564
    GO:0019901protein kinase binding IPI19643732
         
    Find genes that share ontologies with FZD5           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Fzd5):
     behavior/neurological  cardiovascular system  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size/body  mortality/aging  nervous system  vision/eye 

    Find genes that share phenotypes with FZD5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fzd5tm1Mmt for FZD5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FZD5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FZD5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FZD5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FZD5

    miRNA
    Products:
        
    miRTarBase miRNAs that target FZD5:
    hsa-mir-149-5p (MIRT045455), hsa-mir-26b-5p (MIRT030330), hsa-mir-24-3p (MIRT030625)

    Block miRNA regulation of human, mouse, rat FZD5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FZD5 (see all 103):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-100* hsa-miR-3152-3p hsa-miR-4272 hsa-miR-219-5p hsa-miR-374a hsa-miR-877*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FZD5
    Predesigned siRNA for gene silencing in human, mouse, rat FZD5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FZD5

    Clone
    Products:
         
    OriGene clones in human, mouse for FZD5 (see all 7)
    OriGene ORF clones in mouse, rat for FZD5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FZD5 (NM_003468)
    Sino Biological Human cDNA Clone for FZD5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FZD5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FZD5
    Addgene plasmids for FZD5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FZD5
    Browse ESI BIO Cell Lines and PureStem Progenitors for FZD5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD5

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12199) for FZD5 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FZD5_HUMAN, Q13467: Cell membrane; Multi-pass membrane protein (By similarity). Golgi apparatus membrane;
    Multi-pass membrane protein (By similarity). Note=Localized at the plasma membrane and also found at the Golgi
    (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    plasma membrane5
    extracellular2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005737cytoplasm IBA--
    GO:0005769early endosome IEA--
    GO:0005794Golgi apparatus ----
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with FZD5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FZD5 About   (see all 26)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    2beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Ca2+ pathway0.43
    Signaling by Wnt0.79
    3CDK-mediated phosphorylation and removal of Cdc6
    Asymmetric localization of PCP proteins0.75
    WNT5A-dependent internalization of FZD2, FZD5 and ROR20.00
    PCP/CE pathway0.70
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    GSK3 Signaling0.61


    Find genes that share SuperPaths with FZD5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for FZD5
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FZD5 (see all 11)
        Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Colorectal Cancer Metastasis
    Glioblastoma Multiforme

    1 Cell Signaling Technology (CST) Pathway for FZD5
        Wnt / Hedgehog / Notch

    2 GeneGo (Thomson Reuters) Pathways for FZD5
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    5 BioSystems Pathways for FZD5
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway NetPath
    Wnt signaling network
    Canonical Wnt signaling pathway

    2 Sino Biological Pathways for FZD5
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    4 Reactome Pathways for FZD5
        regulation of FZD by ubiquitination
    Ca2+ pathway
    WNT5A-dependent internalization of FZD2, FZD5 and ROR2
    Class B/2 (Secretin family receptors)


    Selected Kegg Pathways  (Kegg details for FZD5) (see all 7):
        Wnt signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection
    Pathways in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FZD5: 
              Notch Signaling Targets in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FZD5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FZD5 (Q134672, 3 ENSP000003546074) via UniProtKB, MINT, STRING, and/or I2D (see all 103)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSK3BP498412, 3, ENSP000003248064MINT-8277466 I2D: score=2 STRING: ENSP00000324806
    RPS6KA6Q9UK322, 3MINT-8277477 I2D: score=2 
    WNT4P567053, ENSP000002901674I2D: score=2 STRING: ENSP00000290167
    GPC5P783333, ENSP000003662674I2D: score=1 STRING: ENSP00000366267
    WNT7AO007553, ENSP000002850184I2D: score=1 STRING: ENSP00000285018
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000578embryonic axis specification IDA12121999
    GO:0001525angiogenesis IBA--
    GO:0001944vasculature development ----
    GO:0006915apoptotic process IBA--
    GO:0007166cell surface receptor signaling pathway ----

    Find genes that share ontologies with FZD5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FZD5

    1 HMDB Compound for FZD5    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FZD5 gene (2 alternative transcripts): 
    NM_003468.3  NM_030804.1  

    Unigene Cluster for FZD5:

    Frizzled family receptor 5
    Hs.17631  [show with all ESTs]
    Unigene Representative Sequence: NM_003468
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000295417(uc002vcj.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FZD5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FZD5 (see all 103):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-100* hsa-miR-3152-3p hsa-miR-4272 hsa-miR-219-5p hsa-miR-374a hsa-miR-877*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FZD5
    Predesigned siRNA for gene silencing in human, mouse, rat FZD5
    Clone
    Products:
         
    OriGene clones in human, mouse for FZD5 (see all 7)
    OriGene ORF clones in mouse, rat for FZD5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FZD5 (NM_003468)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FZD5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FZD5
    Addgene plasmids for FZD5 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FZD5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FZD5
      QuantiTect SYBR Green Assays in human, mouse, rat FZD5
      QuantiFast Probe-based Assays in human, mouse, rat FZD5
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12199) for FZD5 

    Additional mRNA sequence: 

    AB043702.1 AK000125.1 AK024850.1 AK290386.1 AK315338.1 AL136852.1 BC035962.1 BC048322.1 
    BC058895.1 BC095474.1 BC114346.2 U43318.1 

    1 DOTS entry:

    DT.91920372 

    Selected AceView cDNA sequences (see all 113):

    AA947750 AI623200 BM068720 BC058895 AA678167 BM679197 AK024850 AI075306 
    BM683435 AI052347 CA439268 BQ012376 AL713628 BU632532 BM992121 BM311395 
    AA746638 AI352334 AI968329 AA995485 BE502437 AL544988 BQ016658 BX954480 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FZD5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTACAGTTC
    FZD5 Expression
    About this image


    FZD5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
             N2/LSB/S/F8-induced cells
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 6 entries
             hIPS1
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Liver (Hepatobiliary System)
             Liver Bud
     
     Eye (Sensory Organs)
             Retina
    FZD5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FZD5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.17631
        Pathway & Disease-focused RT2 Profiler PCR Arrays including FZD5: 
              Notch Signaling Targets in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FZD5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FZD5
    QuantiTect SYBR Green Assays in human, mouse, rat FZD5
    QuantiFast Probe-based Assays in human, mouse, rat FZD5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for FZD5 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fzd51 , 5 frizzled homolog 5 (Drosophila)1, 5 89.63(n)1
    96.58(a)1
      1 (32.74 cM)5
    143671  NM_001042659.11  NP_001036124.11 
     647305605 
    chicken
    (Gallus gallus)
    Aves FZD51 frizzled family receptor 5 80.28(n)
    82.78(a)
      395571  XM_004942637.1  XP_004942694.1 
    lizard
    (Anolis carolinensis)
    Reptilia FZD56
    frizzled family receptor 5
    74(a)
    1 ↔ 1
    GL343343.1(194929-196683)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fzd51 frizzled family receptor 5 67.6(n)
    78.99(a)
      100488110  XM_004917745.1  XP_004917802.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fzd51 frizzled homolog 5 68.94(n)
    74.01(a)
      30364  NM_131134.2  NP_571209.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta fz21 , 3 Wnt receptor signaling pathway
    transmembrane receptor3
    frizzled 21
    55(a)3
    67.13(n)1
    64(a)1
      400901  NM_001275107.11  NP_001262036.11 


    ENSEMBL Gene Tree for FZD5 (if available)
    TreeFam Gene Tree for FZD5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FZD5 gene
    FZD32  FZD102  FZD82  FZD12  FZD22  FZD92  SFRP42  SMO2  
    FZD42  FZD62  SFRP12  FRZB2  SFRP52  FZD72  SFRP22  
    10 SIMAP similar genes for FZD5 using alignment to 1 protein entry:     FZD5_HUMAN:
    FZD8    FZD2    FZD9    FZD1    FZD7    FZD10
    FZD4    GPCR    FZD6    FZD3

    Find genes that share paralogs with FZD5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FZD5 (see all 170)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1387069391,2
    --208626812(+) TCCAGA/GTAACA 1 -- ds50010--------
    rs576650681,2
    C--208626943(+) CCAACC/TGGACG 1 -- ds50014Minor allele frequency- T:0.29WA NA EA 360
    rs1417329791,2
    --208626951(+) ACGCAC/TAAAAC 1 -- ds50010--------
    rs1839173911,2
    --208626965(+) ATCATC/GTCTAA 1 -- ds50010--------
    rs1893767531,2
    --208627033(+) GTCTCA/TGTTCT 1 -- ds50010--------
    rs557314651,2
    C--208627185(+) TAATAA/CAATTT 1 -- ds50014Minor allele frequency- C:0.37NA EA 244
    rs771458371,2
    F--208627194(+) TTTTGC/TTGCTT 1 -- ds50011Minor allele frequency- T:0.09WA 118
    rs1820769951,2
    --208627375(+) ATTAAC/TTGGGA 1 -- ut310--------
    rs799834421,2
    --208627412(+) TTTTCA/GTAAAT 1 -- ut310--------
    rs1391740091,2
    --208627527(+) TTGAGA/TCTAAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FZD5 (208627310 - 208634287 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FZD5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3133CNV Insertion18451855
    nsv821889CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FZD5
    DNA2.0 Custom Variant and Variant Library Synthesis for FZD5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601723    OMIM disorders: --

    1 disease for FZD5:    
    About MalaCards
    exudative vitreoretinopathy


    Find genes that share disorders with FZD5           About GenesLikeMe

    1 Novoseek inferred disease relationship for FZD5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastric cancer 42 3 17273778 (2)

    Genetic Association Database (GAD): FZD5
    Human Genome Epidemiology (HuGE) Navigator: FZD5 (4 documents)

    Export disorders for FZD5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FZD5 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with FZD5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region. (PubMed id 11408929)1, 2, 3, 9 Saitoh T.... Katoh M. (Int. J. Oncol. 2001)
    2. A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. (PubMed id 8626800)1, 2, 3 Wang Y.... Nathans J. (J. Biol. Chem. 1996)
    3. Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study. (PubMed id 20525402)1, 4 MAPller M....Hoal E.G. (BMC Infect. Dis. 2010)
    4. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    5. Non-association between polymorphisms of the frizzled receptor genes and bone mineral density in postmenopausal Korean women. (PubMed id 19543507)1, 4 Kim J.G....Moon S.Y. (J. Korean Med. Sci. 2009)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    7. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. (PubMed id 9707618)1, 2 Tanaka S.... Sugimachi K. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    8. A member of the Frizzled protein family mediating axis induction by Wnt-5A. (PubMed id 9054360)1, 2 He X.... Varmus H. (Science 1997)
    9. Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer. (PubMed id 17273778)1, 9 Katoh Y. and Katoh M. (Int. J. Oncol. 2007)
    10. The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. (PubMed id 16601243)1, 9 Blumenthal A....Reiling N. (Blood 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7855 HGNC: 4043 AceView: FZD5 Ensembl:ENSG00000163251 euGenes: HUgn7855
    ECgene: FZD5 Kegg: 7855 H-InvDB: FZD5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FZD5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FZD5 gene:
    Search GeneIP for patents involving FZD5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of FZD5
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for FZD5 (Frizzled-5)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for FZD5 (Frizzled-5)   Browse Stem Cell Products  
     cDNA Clones for FZD5 (Frizzled-5)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FZD5   OriGene RNAi products in human, mouse, rat for FZD5  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for FZD5  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FZD5  
     OriGene qSTAR qPCR primer pairs in human, mouse for FZD5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FZD5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FZD5   OriGene Custom Protein Services for FZD5  

     
     
     Block miRNA regulation of human, mouse, rat FZD5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FZD5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FZD5 Predesigned siRNA for gene silencing in human, mouse, rat FZD5
     QuantiFast Probe-based Assays in human, mouse, rat FZD5 QuantiTect SYBR Green Assays in human, mouse, rat FZD5
     PCR Arrays including human, mouse, rat FZD5 Search Chromatin IP Primers for FZD5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FZD5  GeneGlobe Interaction Network for FZD5
     Regulatory tfbs in FZD5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FZD5 GenScript cDNA clones with any tag delivered in your preferred vector for FZD5
     GenScript Custom Assay Services for FZD5 GenScript Custom overexpressing Cell Line Services for FZD5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for FZD5 

     Search Tocris compounds for FZD5
     Proteins for FZD5
     Cell Lysates for FZD5
     cDNA Clones for FZD5
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FZD5 antibodies
     FZD5 proteins
     FZD5 lysates
     Antibodies for FZD5
     See all of Abcam's Antibodies, Kits and Proteins for FZD5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FZD5
     Antibodies for FZD5
     ELISAs for FZD5
     CLIAs for FZD5



     Browse ESI BIO Cell Lines and PureStem Progenitors for FZD5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD5
     Browse SwitchGear 3'UTR luciferase reporter plasmids for FZD5
     SwitchGear Promoter luciferase reporter plasmids for FZD5
     ThermoFisher Antibody for FZD5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FZD5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FZD5
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FZD5
     LSBio Antibodies in human, mouse, rat for FZD5
     Browse compounds at ApexBio
     Addgene plasmids for FZD5
      Search eBioscience for proteins for FZD5
      Search eBioscience for elisas for FZD5
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for FZD5 (74 products)
     antibodies-online kits for FZD5 (3 products)
     antibodies-online peptides for FZD5
     antibodies-online proteins for FZD5 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FZD5 gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4