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Aliases for FZD5 Gene

Aliases for FZD5 Gene

  • Frizzled Class Receptor 5 2 3
  • Frizzled 5, Seven Transmembrane Spanning Receptor 2 3
  • Frizzled Family Receptor 5 2 3
  • C2orf31 3 4
  • HFZ5 3 4
  • Fz-5 3 4
  • FzE5 3 4
  • Seven-Transmembrane Receptor Frizzled-5 3
  • Chromosome 2 Open Reading Frame 31 2
  • Frizzled (Drosophila) Homolog 5 2
  • Frizzled Homolog 5 (Drosophila) 2
  • Wnt Receptor 3
  • Frizzled-5 3

External Ids for FZD5 Gene

Previous Symbols for FZD5 Gene

  • C2orf31

Summaries for FZD5 Gene

Entrez Gene Summary for FZD5 Gene

  • Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. [provided by RefSeq, Jul 2008]

GeneCards Summary for FZD5 Gene

FZD5 (Frizzled Class Receptor 5) is a Protein Coding gene. Diseases associated with FZD5 include exudative vitreoretinopathy. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include G-protein coupled receptor activity and ubiquitin protein ligase binding. An important paralog of this gene is FZD10.

UniProtKB/Swiss-Prot for FZD5 Gene

  • Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta-catenin pathway.

Gene Wiki entry for FZD5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FZD5 Gene

Genomics for FZD5 Gene

Genomic Location for FZD5 Gene

Start:
207,762,586 bp from pter
End:
207,769,563 bp from pter
Size:
6,978 bases
Orientation:
Minus strand

Genomic View for FZD5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FZD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FZD5 Gene

Regulatory Elements for FZD5 Gene

Proteins for FZD5 Gene

  • Protein details for FZD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13467-FZD5_HUMAN
    Recommended name:
    Frizzled-5
    Protein Accession:
    Q13467
    Secondary Accessions:
    • A8K2X1
    • B2RCZ1
    • Q53R22

    Protein attributes for FZD5 Gene

    Size:
    585 amino acids
    Molecular mass:
    64507 Da
    Quaternary structure:
    • Interacts with GOPC.

neXtProt entry for FZD5 Gene

Proteomics data for FZD5 Gene at MOPED

Post-translational modifications for FZD5 Gene

  • Ubiquitinated by RNF43 and ZNRF3, leading to its degradation by the proteasome.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn47 and Asn151

Other Protein References for FZD5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FZD5 Gene

Domains for FZD5 Gene

Gene Families for FZD5 Gene

HGNC:
  • FZD :GPCR / Class F : Frizzled receptors
IUPHAR :

Protein Domains for FZD5 Gene

UniProtKB/Swiss-Prot:

FZD5_HUMAN
Domain:
  • The PDZ-binding motif mediates interaction with GOPC.:
    • Q13467
  • Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.:
    • Q13467
  • The FZ domain is involved in binding with Wnt ligands.:
    • Q13467
  • Contains 1 FZ (frizzled) domain.:
    • Q13467
Family:
  • Belongs to the G-protein coupled receptor Fz/Smo family.:
    • Q13467
genes like me logo Genes that share domains with FZD5: view

Function for FZD5 Gene

Molecular function for FZD5 Gene

GENATLAS Biochemistry: Drosophila frizzled polarity gene homolog 5,G protein coupled receptor superfamily,exhibiting characteristics of a WNT receptor,(WNT5A,at least in Xenopus),involved in signal transduction,activating Dishevelled
UniProtKB/Swiss-Prot Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta-catenin pathway.

Gene Ontology (GO) - Molecular Function for FZD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity IBA --
GO:0005515 protein binding IPI 18838381
GO:0017147 Wnt-protein binding IPI 12490564
GO:0019901 protein kinase binding IPI 19643732
genes like me logo Genes that share ontologies with FZD5: view
genes like me logo Genes that share phenotypes with FZD5: view

Animal Models for FZD5 Gene

MGI Knock Outs for FZD5:

miRNA for FZD5 Gene

miRTarBase miRNAs that target FZD5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FZD5 Gene

Localization for FZD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FZD5 Gene

Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane and also found at the Golgi. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FZD5 Gene COMPARTMENTS Subcellular localization image for FZD5 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 5
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for FZD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm --
GO:0005769 early endosome --
GO:0005794 Golgi apparatus --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with FZD5: view

Pathways for FZD5 Gene

genes like me logo Genes that share pathways with FZD5: view

Gene Ontology (GO) - Biological Process for FZD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000578 embryonic axis specification IDA 12121999
GO:0001525 angiogenesis IEA --
GO:0001944 vasculature development --
GO:0002726 positive regulation of T cell cytokine production IDA 16601243
GO:0006915 apoptotic process --
genes like me logo Genes that share ontologies with FZD5: view

Compounds for FZD5 Gene

(1) HMDB Compounds for FZD5 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with FZD5: view

Transcripts for FZD5 Gene

mRNA/cDNA for FZD5 Gene

(2) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(113) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FZD5 Gene

Frizzled family receptor 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FZD5 Gene

No ASD Table

Relevant External Links for FZD5 Gene

GeneLoc Exon Structure for
FZD5
ECgene alternative splicing isoforms for
FZD5

Expression for FZD5 Gene

mRNA expression in normal human tissues for FZD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FZD5 Gene

This gene is overexpressed in Colon - Transverse (6.5) and Liver (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FZD5 Gene

SOURCE GeneReport for Unigene cluster for FZD5 Gene Hs.17631

genes like me logo Genes that share expressions with FZD5: view

Orthologs for FZD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for FZD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FZD5 36
  • 99.72 (n)
  • 99.66 (a)
FZD5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FZD5 36
  • 93.45 (n)
  • 96.75 (a)
FZD5 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FZD5 36
  • 94.52 (n)
  • 96.4 (a)
FZD5 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fzd5 36
  • 89.63 (n)
  • 96.58 (a)
Fzd5 16
Fzd5 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FZD5 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FZD5 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fzd5 36
  • 89.06 (n)
  • 96.41 (a)
chicken
(Gallus gallus)
Aves FZD5 36
  • 80.28 (n)
  • 82.78 (a)
lizard
(Anolis carolinensis)
Reptilia FZD5 37
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fzd5 36
  • 67.6 (n)
  • 78.99 (a)
zebrafish
(Danio rerio)
Actinopterygii fzd5 36
  • 68.94 (n)
  • 74.01 (a)
fzd5 37
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta GPRFZ2 36
  • 67 (n)
  • 64.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta fz2 36
  • 67.13 (n)
  • 64 (a)
fz2 37
  • 49 (a)
OneToMany
fz2 38
  • 55 (a)
worm
(Caenorhabditis elegans)
Secernentea mom-5 38
  • 36 (a)
cfz-2 38
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 35 (a)
OneToMany
Species with no ortholog for FZD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FZD5 Gene

ENSEMBL:
Gene Tree for FZD5 (if available)
TreeFam:
Gene Tree for FZD5 (if available)

Paralogs for FZD5 Gene

Paralogs for FZD5 Gene

Selected SIMAP similar genes for FZD5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FZD5: view

Variants for FZD5 Gene

Sequence variations from dbSNP and Humsavar for FZD5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs14616 -- 207,762,860(+) AGAAA(A/C)AAAAA utr-variant-3-prime
rs698910 -- 207,765,913(+) AGGGG(G/T)GAGGG utr-variant-3-prime
rs1056614 -- 207,768,478(-) TATGC(A/T)CTATG missense, reference
rs1134843 -- 207,769,273(-) CGGGA(G/T)CCGTG utr-variant-5-prime
rs2292299 -- 207,763,679(+) TTAAA(A/C)TATAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FZD5 Gene

Variant ID Type Subtype PubMed ID
nsv3133 CNV Insertion 18451855
nsv821889 CNV Gain 20364138

Relevant External Links for FZD5 Gene

HapMap Linkage Disequilibrium report
FZD5

Disorders for FZD5 Gene

(1) Novoseek inferred disease relationships for FZD5 Gene

Disease -log(P) Hits PubMed IDs
gastric cancer 42 2

Relevant External Links for FZD5

Genetic Association Database (GAD)
FZD5
Human Genome Epidemiology (HuGE) Navigator
FZD5
genes like me logo Genes that share disorders with FZD5: view

No data available for UniProtKB/Swiss-Prot for FZD5 Gene

Publications for FZD5 Gene

  1. Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region. (PMID: 11408929) Saitoh T. … Katoh M. (Int. J. Oncol. 2001) 2 3 4 23
  2. A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. (PMID: 8626800) Wang Y. … Nathans J. (J. Biol. Chem. 1996) 2 3 4
  3. A member of the Frizzled protein family mediating axis induction by Wnt-5A. (PMID: 9054360) He X. … Varmus H. (Science 1997) 3 4
  4. Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study. (PMID: 20525402) MAPller M. … Hoal E.G. (BMC Infect. Dis. 2010) 3 49
  5. The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. (PMID: 16601243) Blumenthal A. … Reiling N. (Blood 2006) 3 23

Products for FZD5 Gene

  • Addgene plasmids for FZD5

Sources for FZD5 Gene

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