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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FZD5 Gene

protein-coding GIFtS: 63
GCID: GC02M208594

frizzled family receptor 5

(Previous names: frizzled (Drosophila) homolog 5, chromosome 2 open reading...)
(Previous symbol: C2orf31)

Explore 16 diseases affiliated with
FZD5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Frizzled Family Receptor 5¹ ²		Frizzled-5¹
C2orf31¹ ² ³		Fz-5³
HFZ5¹ ²		FzE5³
Frizzled 5, Seven Transmembrane Spanning Receptor¹ ²		Seven-Transmembrane Receptor Frizzled-5²
DKFZP434E2135¹		Wnt Receptor²
Chromosome 2 Open Reading Frame 31¹		Fz-5³
Frizzled (Drosophila) Homolog 5¹		FzE5³
Frizzled Homolog 5 (Drosophila)¹		HFz5¹

External Ids:	HGNC: 4043¹	Entrez Gene: 7855²	Ensembl: ENSG00000163251⁷	OMIM: 601723⁵	UniProtKB: Q13467³

Export aliases for FZD5 gene to outside databases

Previous GC identifers: GC02M206847 GC02M207355 GC02M208833 GC02M208456 GC02M208338 GC02M200469

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FZD5:

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling

proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FZD5_HUMAN, Q13467

Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling

pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of

beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been

seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated

in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways

seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of

polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A

to induce the beta-catenin pathway

Gene Wiki entry for FZD5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FZD5 gene promoter:
E2F-4 E2F-3a E2F-5 Pax-5 E2F-2 E47 CREB HEN1 E2F E2F-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FZD5 promoter sequence

Search SABiosciences Chromatin IP Primers for FZD5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FZD5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.3 Ensembl cytogenetic band: 2q33.3 HGNC cytogenetic band: 2q33.3

FZD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZD5 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M208594: view genomic region (about GC identifiers)

Start:	208,627,310 bp from pter	End:	208,634,287 bp from pter
Size:	6,978 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FZD5_HUMAN, Q13467 (See protein sequence)

Recommended Name: Frizzled-5 precursor

Size: 585 amino acids; 64507 Da

Subunit: Interacts with GOPC (By similarity)

Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity). Golgi apparatus membrane; Multi-pass

membrane protein (By similarity). Note=Localized at the plasma membrane and also found at the Golgi (By similarity)

Secondary accessions: Q53R22

Explore the universe of human proteins at neXtProt for FZD5: NX_Q13467

Post-translational modifications:

Ubiquitinated by RNF43 and ZNRF3, leading to its degradation by the proteasome¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13467

FZD5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003459.2

ENSEMBL proteins:

ENSP00000354607

Reactome Protein details: Q13467
Human Recombinant Protein Products:

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	Sino Biological Recombinant Protein for FZD5
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FZD5

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005737	cytoplasm	IBA	--
GO:0005886	plasma membrane	TAS	--
GO:0009986	cell surface	IDA	19643732
GO:0016021	integral to membrane	IEA	--

FZD5 for ontologies About GeneDecksing

FZD5 Antibody Products:

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	Uscn Antibodies for FZD5
	ThermoFisher Antibodies for FZD5

Assay Products for FZD5:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FZD5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FZD5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FZD5 for domains About GeneDecksing

5 InterPro domains/families:

IPR000539 Frizzled

IPR020067 Frizzled_dom

IPR015526 Frizzled/SFRP

IPR017981 GPCR_2-like

IPR026547 FZD5

Graphical View of Domain Structure for InterPro Entry Q13467

ProtoNet protein and cluster: Q13467

1 Blocks protein family: IPB000539 Frizzled protein signature

UniProtKB/Swiss-Prot: FZD5_HUMAN, Q13467

Domain: The PDZ-binding motif mediates interaction with GOPC (By similarity)

Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the

activation of the Wnt/beta-catenin signaling pathway (By similarity)

Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)

Similarity: Belongs to the G-protein coupled receptor Fz/Smo family

Similarity: Contains 1 FZ (frizzled) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FZD5_HUMAN, Q13467

Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling

pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of

beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been

seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated

in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways

seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of

polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A

to induce the beta-catenin pathway

Genatlas biochemistry entry for FZD5:

Drosophila frizzled polarity gene homolog 5,G protein coupled receptor superfamily,exhibiting characteristics of a WNT

receptor,(WNT5A,at least in Xenopus),involved in signal transduction,activating Dishevelled

miRNA Products:		OriGene 3'-UTR Clone: FZD5 Browse MicroRNA Expression Plasmids
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		hsa-miR-323-3p hsa-miR-579 hsa-miR-100* hsa-miR-3152-3p hsa-miR-4272 hsa-miR-219-5p hsa-miR-374a hsa-miR-877*

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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for FZD5

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		Search LifeMap BioReagents cell lines for FZD5

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD5

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0005515	protein binding	IPI	18838381
GO:0017147	Wnt-protein binding	IPI	12490564
GO:0019901	protein kinase binding	IPI	19643732
GO:0030165	PDZ domain binding	IBA	--

FZD5 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Fzd5^tm1Mmt for FZD5
     9 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Fzd5):

behavior/neurological	cardiovascular system	digestive/alimentary	embryogenesis	endocrine/exocrine gland
growth/size	mortality/aging	nervous system	vision/eye

FZD5 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Wnt Signaling Pathway

Wnt Signaling Pathway	1.00	Wnt signaling pathway	0.30
Wnt Signaling Pathway and Pluripotency	0.55	Wnt Signaling Pathway NetPath	0.22
Wnt Signaling Pathway	0.33

Translation_Non-genomic (rapid) action of Androgen Receptor

Translation_Non-genomic (rapid) action of Androgen Receptor

1.00

Translation Non-genomic (rapid) action of Androgen Receptor

0.99

Transcription_Androgen Receptor nuclear signaling

Transcription_Androgen Receptor nuclear signaling

1.00

Transcription Androgen Receptor nuclear signaling

0.99

Nanog in Mammalian ESC Pluripotency

Nanog in Mammalian ESC Pluripotency

1.00

GSK3 Signaling

0.61

Human Embryonic Stem Cell Pluripotency

Human Embryonic Stem Cell Pluripotency

1.00

Factors Promoting Cardiogenesis in Vertebrates

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for FZD5

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

1 R&D Systems Pathway for FZD5

Wnt Signaling Pathway

5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FZD5 (see all 11)

	Factors Promoting Cardiogenesis in Vertebrates
	Molecular Mechanisms of Cancer
	G12-G13 in Cellular Signaling
	Colorectal Cancer Metastasis
	Glioblastoma Multiforme

1 Cell Signaling Technology (CST) Pathway for FZD5

Wnt / Hedgehog / Notch

2 GeneGo (Thomson Reuters) Pathways for FZD5

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

5 BioSystems Pathways for FZD5

	Wnt Signaling Pathway
	Wnt Signaling Pathway and Pluripotency
	Wnt Signaling Pathway NetPath
	Canonical Wnt signaling pathway
	Wnt signaling network

4 Reactome Pathways for FZD5

	Signal Transduction
	Signaling by GPCR
	GPCR ligand binding
	Class B/2 (Secretin family receptors)

4 Kegg Pathways (Kegg details for FZD5):

	Wnt signaling pathway
	Melanogenesis
	Pathways in cancer
	Basal cell carcinoma

FZD5 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FZD5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/60 Interacting proteins for FZD5 (Q13467^{2, 3} ENSP00000354607⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 60)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GSK3B	P49841²^,³, ENSP00000324806⁴	MINT-8277466 I2D: score=2 STRING: ENSP00000324806
RPS6KA6	Q9UK32²^,³	MINT-8277477 I2D: score=2
WNT4	P56705³, ENSP00000290167⁴	I2D: score=2 STRING: ENSP00000290167
WNT7A	O00755³, ENSP00000285018⁴	I2D: score=1 STRING: ENSP00000285018
WNT7B	P56706³, ENSP00000341032⁴	I2D: score=1 STRING: ENSP00000341032

About this table

Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000578	embryonic axis specification	IDA	12121999
GO:0001525	angiogenesis	IBA	--
GO:0001944	vasculature development	--	--
GO:0006915	apoptotic process	IBA	--
GO:0007409	axonogenesis	IBA	--

FZD5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FZD5

1 HMDB Compound for FZD5 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about FZD5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FZD5 gene (2 alternative transcripts):

NM_003468.3 NM_030804.1

Unigene Cluster for FZD5:

Frizzled family receptor 5

Hs.17631 [show with all ESTs]

Unigene Representative Sequence: NM_003468

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000295417(uc002vcj.3)

miRNA Products:		OriGene 3'-UTR Clone: FZD5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FZD5
		8/103 QIAGEN miScript miRNA Assays for microRNAs that regulate FZD5 (see all 103):
		hsa-miR-323-3p hsa-miR-579 hsa-miR-100* hsa-miR-3152-3p hsa-miR-4272 hsa-miR-219-5p hsa-miR-374a hsa-miR-877*

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FZD5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FZD5

Additional cDNA sequence:

AB043702.1 AK000125.1 AK024850.1 AK290386.1 AK315338.1 AL136852.1 BC035962.1 BC048322.1

BC058895.1 BC095474.1 BC114346.2 U43318.1

1 DOTS entry:

DT.91920372

24/113 AceView cDNA sequences (see all 113):

BM068720 AA935250 BE502437 AL544988 CB160719 AA947750 AA746638 AA778881

CR594249 BQ005496 BQ012871 AI623200 AA927018 BC058895 AL713628 AA126555

BM311395 BU632532 AA995485 BM679197 AI052347 AI352334 BQ016658 BE504696

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FZD5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTACAGTTC

About this image

FZD5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Trophoblast

Mural Trophectoderm

Mural Trophectoderm Cells

Selective marker (cell-identifying gene)

Extraembryonic Tissues

Kidney

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

N2/LSB/S/F8-induced cells (Generation of midbra...)

Definitive endoderm-like cells (A scalable, suspensi...)

See FZD5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FZD5

SOURCE GeneReport for Unigene cluster: Hs.17631

SABiosciences Expression via Pathway-Focused PCR Arrays including FZD5:

Notch Signaling Targets in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

WNT Signaling Pathway in human mouse rat

Stem Cell Signaling in human mouse rat

Notch Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FZD5 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FZD5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FZD5 gene from 5/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FZD5¹	frizzled family receptor 5	79.89(n) 81.85(a)		395571 XM_426568.3 XP_426568.3
lizard (Anolis carolinensis)	Reptilia	FZD5⁶	--	75(a)	1 ↔ 1	GL343343.1(194929-197396)
zebrafish (Danio rerio)	Actinopterygii	fzd5¹	frizzled homolog 5	68.73(n) 73.81(a)		30364 NM_131134.2 NP_571209.2
fruit fly (Drosophila melanogaster)	Insecta	fz2^{1 , 3}	Wnt receptor signaling pathway transmembrane receptor³ frizzled 2¹	55(a)³ 67.13(n)¹ 64(a)¹		40090¹ NM_168787.2¹ NP_730389.1¹
worm (Caenorhabditis elegans)	Secernentea	cfz-2³	transmembrane receptor	39(a) (best of 2)		V(3441666-3444584) --

ENSEMBL Gene Tree for FZD5 (if available)
TreeFam Gene Tree for FZD5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FZD5 gene

FZD10² FZD3² FZD8² FZD1² FZD2² FZD9² SFRP4² SMO²

FZD4² FZD6² SFRP1² FRZB² FZD7² SFRP5² SFRP2²

10 SIMAP similar genes for FZD5 using alignment to 1 protein entry: FZD5_HUMAN:

FZD8 FZD2 FZD9 FZD1 FZD7 FZD10

FZD4 GPCR FZD6 FZD3

FZD5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201741699^1,2	C	--	200473011(-)	`GTGATC/TCCCTT`	1	--	ut3¹		0	--	--	--	--
rs138706939^1,2		--	208626812(+)	`TCCAGA/GTAACA`	1	--	ds500¹		0	--	--	--	--
rs57665068^1,2	C,	--	208626943(+)	`CCAACC/TGGACG`	1	--	ds500¹		4		WA NA EA	360
rs141732979^1,2		--	208626951(+)	`ACGCAC/TAAAAC`	1	--	ds500¹		0	--	--	--	--
rs183917391^1,2		--	208626965(+)	`ATCATC/GTCTAA`	1	--	ds500¹		0	--	--	--	--
rs189376753^1,2		--	208627033(+)	`GTCTCA/TGTTCT`	1	--	ds500¹		0	--	--	--	--
rs55731465^1,2	C,	--	208627185(+)	`TAATAA/CAATTT`	1	--	ds500¹		4		NA EA	244
rs77145837^1,2	F,	--	208627194(+)	`TTTTGC/TTGCTT`	1	--	ds500¹		1		WA	118
rs182076995^1,2		--	208627375(+)	`ATTAAC/TTGGGA`	1	--	ut3¹		0	--	--	--	--
rs79983442^1,2		--	208627412(+)	`TTTTCA/GTAAAT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FZD5 (208627310 - 208634287 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FZD5: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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FZD5 for disorders           About GeneDecksing

OMIM gene information: 601723    OMIM disorders: --

16 diseases for FZD5:    About MalaCards

exudative vitreoretinopathy vitreoretinopathy basal cell carcinoma gastric cancer

esophageal carcinoma esophagitis ovarian cancer psoriasis

carcinoma retinitis tuberculosis pancreatitis

prostatitis neuronitis colorectal cancer glioblastoma

1 Novoseek disease relationship for FZD5 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gastric cancer	42	3	17273778 (2)

Human Genome Epidemiology (HuGE) Navigator: FZD5 (4 documents)

Export disorders for FZD5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FZD5 gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with FZD5)

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Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region. (PubMed id 11408929)^{1, 2, 3, 9} Saitoh T....Katoh M. (2001)
A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. (PubMed id 8626800)^{1, 2, 3} Wang Y.... Nathans J. (1996)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. (PubMed id 9707618)^{1, 2} Tanaka S.... Sugimachi K. (1998)
A member of the Frizzled protein family mediating axis induction by Wnt-5A. (PubMed id 9054360)^{1, 2} He X.... Varmus H. (1997)
Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer. (PubMed id 17273778)^{1, 9} Katoh Y. and Katoh M. (2007)
The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. (PubMed id 16601243)^{1, 9} Blumenthal A....Reiling N. (2006)
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling. (PubMed id 18838381)^{1, 9} Lin Z....Chen Y.G. (2008)
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. (PubMed id 22895187)² Koo B.K....Clevers H. (2012)
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. (PubMed id 22575959)² Hao H.X....Cong F. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7855	HGNC: 4043	AceView: FZD5	Ensembl:ENSG00000163251	euGenes: HUgn7855
ECgene: FZD5	Kegg: 7855	H-InvDB: FZD5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for FZD5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FZD5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FZD5 gene:
Search GeneIP for patents involving FZD5

GeneCards and IP:
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frizzled family receptor 5

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