Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FZD3 Gene

protein-coding   GIFtS: 66
GCID: GC08P028351

Frizzled Family Receptor 3

(Previous names: frizzled (Drosophila) homolog 3, frizzled homolog 3 (Drosophila),...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Frizzled Family Receptor 31 2     Frizzled Homolog 3 (Drosophila)1
Frizzled 3, Seven Transmembrane Spanning Receptor1 2     Frizzled Homolog 32
Fz-32 3     frizzled-32
Frizzled (Drosophila) Homolog 31     hFz33

External Ids:    HGNC: 40411   Entrez Gene: 79762   Ensembl: ENSG000001042907   OMIM: 6061435   UniProtKB: Q9NPG13   

Export aliases for FZD3 gene to outside databases

Previous GC identifers: GC08P028134 GC08P028857 GC08P028373 GC08P028407 GC08P026897


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FZD3 Gene:
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain
proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most
frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is
unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in
multiple transcript variants. This gene is a susceptibility locus for schizophrenia. (provided by RefSeq, Dec
2010)

GeneCards Summary for FZD3 Gene: 
FZD3 (frizzled family receptor 3) is a protein-coding gene. Diseases associated with FZD3 include schizophrenia, and strabismus, and among its related super-pathways are Wnt signaling pathway and GPCR downstream signaling. GO annotations related to this gene include Wnt-protein binding and G-protein coupled receptor activity. An important paralog of this gene is FZD10.

UniProtKB/Swiss-Prot: FZD3_HUMAN, Q9NPG1
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical
signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear
accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and
calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway
or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of
GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and
intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues

Gene Wiki entry for FZD3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FZD3 gene promoter:
         Egr-3   C/EBPbeta   Tal-1beta   E4BP4   GATA-1   YY1   POU2F1   HFH-1   FOXO4   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFZD3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FZD3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FZD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21   Ensembl cytogenetic band:  8p21.1   HGNC cytogenetic band: 8p21

FZD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZD3 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P028351:  view genomic region     (about GC identifiers)

Start:
28,351,722 bp from pter      End:
28,431,785 bp from pter
Size:
80,064 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FZD3_HUMAN, Q9NPG1 (See protein sequence)
Recommended Name: Frizzled-3 precursor  
Size: 666 amino acids; 76263 Da
Subunit: Interacts with VANGL2 (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By
similarity)
Alternative splicing: 2 isoforms:  Q9NPG1-1   Q9NPG1-2   

Explore the universe of human proteins at neXtProt for FZD3: NX_Q9NPG1

Explore proteomics data for FZD3 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NPG1

  • FZD3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FZD3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_059108.1  NP_665873.1  

    ENSEMBL proteins: 
     ENSP00000430125   ENSP00000240093   ENSP00000437489  
    Reactome Protein details: Q9NPG1
    Human Recombinant Protein Products for FZD3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for FZD3
    GenScript Custom Purified and Recombinant Proteins Services for FZD3
    Novus Biologicals FZD3 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FZD3 

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA19038973
    GO:0005886plasma membrane IDA19038973
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--
    GO:0016324apical plasma membrane IEA--

    FZD3 for ontologies           About GeneDecksing



    FZD3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FZD3 (Frizzled-3)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FZD3
    GenScript Custom Superior Antibodies Services for FZD3
    Novus Biologicals FZD3 Antibodies
    Abcam antibodies for FZD3
    Cloud-Clone Corp. Antibodies for FZD3 
    ThermoFisher Antibodies for FZD3
    LSBio Antibodies in human, mouse, rat for FZD3 

    Assay Products for FZD3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FZD3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FZD3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FZD3 
    Cloud-Clone Corp. CLIAs for FZD3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FZD: GPCR / Class F : Frizzled receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: FZD3 
    Frizzled Class GPCRs

    5 InterPro protein domains:
     IPR000539 Frizzled
     IPR020067 Frizzled_dom
     IPR026553 FZD3_chordata
     IPR015526 Frizzled/SFRP
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry Q9NPG1

    ProtoNet protein and cluster: Q9NPG1

    1 Blocks protein domain: IPB000539 Frizzled protein signature

    UniProtKB/Swiss-Prot: FZD3_HUMAN, Q9NPG1
    Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in
    the activation of the Wnt/beta-catenin signaling pathway (By similarity)
    Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
    Similarity: Belongs to the G-protein coupled receptor Fz/Smo family
    Similarity: Contains 1 FZ (frizzled) domain


    FZD3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FZD3_HUMAN, Q9NPG1
    Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical
    signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear
    accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and
    calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway
    or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of
    GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and
    intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005515protein binding IPI19277043
    GO:0017147Wnt-protein binding IPI19038973
    GO:0030165PDZ domain binding IPI18256285
         
    FZD3 for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fzd3):
     behavior/neurological  cellular  embryogenesis  growth/size  hearing/vestibular/ear 
     homeostasis/metabolism  limbs/digits/tail  mortality/aging  nervous system  reproductive system 
     respiratory system  vision/eye 

    FZD3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FZD3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FZD3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FZD3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FZD3 

    miRNA
    Products:
        
    miRTarBase miRNAs that target FZD3:
    hsa-mir-31 (MIRT004984)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FZD3
    8/186 QIAGEN miScript miRNA Assays for microRNAs that regulate FZD3 (see all 186):
    hsa-miR-411* hsa-miR-579 hsa-miR-361-5p hsa-miR-640 hsa-miR-106a hsa-miR-128 hsa-miR-759 hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidFZD3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FZD3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FZD3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FZD3
    Sirion Biotech Customized adenovirus for overexpression of FZD3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FZD3 (see all 7)
    OriGene ORF clones in mouse, rat for FZD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FZD3 (NM_017412)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FZD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FZD3
    Sirion Biotech Customized lentivirus for stable overexpression of FZD3 
                         Customized lentivirus expression plasmids for stable overexpression of FZD3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FZD3
    Search LifeMap BioReagents cell lines for FZD3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FZD3 About   (see all 22)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway0.40
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    GSK3 Signaling0.61
    4Wnt Signaling Pathway
    Wnt Signaling Pathway0.55
    Wnt Signaling Pathway and Pluripotency0.55
    5Human Embryonic Stem Cell Pluripotency
    Human Embryonic Stem Cell Pluripotency0.50
    Factors Promoting Cardiogenesis in Vertebrates0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for FZD3
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 R&D Systems Pathway for FZD3
        Wnt Signaling Pathway

    5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FZD3 (see all 11)
        Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Colorectal Cancer Metastasis
    Glioblastoma Multiforme

    2 GeneGo (Thomson Reuters) Pathways for FZD3
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    3 BioSystems Pathways for FZD3
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    Neural Crest Differentiation

    4        Reactome Pathways for FZD3
        Signal Transduction
    Signaling by GPCR
    GPCR ligand binding
    Class B/2 (Secretin family receptors)


    5/8         Kegg Pathways  (Kegg details for FZD3) (see all 8):
        Wnt signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection
    Pathways in cancer


    FZD3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FZD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for FZD3 (Q9NPG13 ENSP000002400934) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GIPC2Q8TF653, ENSP000003597954I2D: score=1 STRING: ENSP00000359795
    WNT1P046283, ENSP000002935494I2D: score=1 STRING: ENSP00000293549
    GIPC1O149083, ENSP000003406984I2D: score=1 STRING: ENSP00000340698
    GIPC3Q8TF643, ENSP000003192544I2D: score=1 STRING: ENSP00000319254
    DVL1ENSP000003681694STRING: ENSP00000368169
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001736establishment of planar polarity IBA--
    GO:0001764neuron migration IEA--
    GO:0001843neural tube closure IBA--
    GO:0001942hair follicle development IEA--
    GO:0001944vasculature development IBA--

    FZD3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FZD3

    1 HMDB Compound for FZD3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about FZD3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FZD3 gene (2 alternative transcripts): 
    NM_017412.3  NM_145866.1  

    Unigene Cluster for FZD3:

    Frizzled family receptor 3
    Hs.40735  [show with all ESTs]
    Unigene Representative Sequence: NM_017412
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000523546 ENST00000240093(uc003xgx.3 uc010lvb.3) ENST00000517911
    ENST00000537916
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FZD3
    8/186 QIAGEN miScript miRNA Assays for microRNAs that regulate FZD3 (see all 186):
    hsa-miR-411* hsa-miR-579 hsa-miR-361-5p hsa-miR-640 hsa-miR-106a hsa-miR-128 hsa-miR-759 hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidFZD3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FZD3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FZD3
    Clone
    Products:
         
    OriGene clones in human, mouse for FZD3 (see all 7)
    OriGene ORF clones in mouse, rat for FZD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FZD3 (NM_017412)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FZD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FZD3
    Sirion Biotech Customized lentivirus for stable overexpression of FZD3 
                         Customized lentivirus expression plasmids for stable overexpression of FZD3 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FZD3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FZD3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FZD3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FZD3

    Additional mRNA sequence: 

    AB039723.1 AJ272427.1 AK291480.1 AY005130.3 BC034278.1 BC042009.1 

    8 DOTS entries:

    DT.311096  DT.40278282  DT.213415  DT.40111614  DT.40274870  DT.120643797  DT.86837570  DT.91749033 

    24/41 AceView cDNA sequences (see all 41):

    AJ272427 BE464229 CF147250 NM_017412 AI261609 BC034278 AW301180 AY005130 
    AB039723 BM471082 BU187770 AL527948 H41349 AI580985 AA436403 BG697895 
    AA035080 CF243017 BM558534 H84795 AA897676 BX280696 AA481346 AA223989 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FZD3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                                  


    ECgene alternative splicing isoforms for FZD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FZD3 expression in normal human tissues (normalized intensities)      FZD3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATCAATCA
    FZD3 Expression
    About this image


    FZD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/42 selected tissues (see all 42) fully expand
     
     Brain (Nervous System)    fully expand to see all 28 entries
             Thalamus
             Septum   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; endothelial cells   

    See FZD3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FZD3

    SOURCE GeneReport for Unigene cluster: Hs.40735

    UniProtKB/Swiss-Prot: FZD3_HUMAN, Q9NPG1
    Tissue specificity: Widely expressed. Relatively high expression in the CNS, including regions of the limbic
    system, in kidney, pancreas, skeletal muscle, uterus and testis

        SABiosciences Expression via Pathway-Focused PCR Arrays including FZD3: 
              G Protein Coupled Receptors 384HT in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FZD3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FZD3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FZD3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FZD3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FZD3 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fzd31 , 5 frizzled homolog 3 (Drosophila)1, 5 92.24(n)1
    98.2(a)1
      14 (34.09 cM)5
    143651  NM_021458.21  NP_067433.11 
     652010265 
    chicken
    (Gallus gallus)
    Aves FZD31 frizzled family receptor 3 82.08(n)
    94.29(a)
      395572  XM_420029.3  XP_420029.2 
    lizard
    (Anolis carolinensis)
    Reptilia FZD36
    Uncharacterized protein
    92(a)
    1 ↔ 1
    GL343529.1(74398-126070)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.11862 Xenopus laevis mRNA for frizzled 3 protein 79.09(n)    AJ001754.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fzd3a1 frizzled homolog 3a 68.22(n)
    76.28(a)
      565921  NM_001042761.2  NP_001036226.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fz33 establishment and/or maintenance of
    cell polarity more
    26(a)   1C4   --
    worm
    (Caenorhabditis elegans)
    Secernentea mom-53 Drosophila tissue polarity protein like 34(a)   I(9973695-9977388)   --


    ENSEMBL Gene Tree for FZD3 (if available)
    TreeFam Gene Tree for FZD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FZD3 gene
    FZD102  FZD82  FZD12  FZD52  FZD22  FZD92  SFRP42  SMO2  
    FZD42  FZD62  SFRP12  FRZB2  SFRP52  FZD72  SFRP22  
    9 SIMAP similar genes for FZD3 using alignment to 2 protein entries:     FZD3_HUMAN (see all proteins):
    GPCR    FZD6    FZD1    FZD2    FZD7    FZD10
    FZD5    FZD9    FZD4

    FZD3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1632 SNPs in FZD3 are shown (see all 1632)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0669624
    ----see VAR_0669622 I V mis40--------
    VAR_0669614
    ----see VAR_0669612 L M mis40--------
    rs1467040331,2
    C--26911201(+) TTTTT-/TTAAGGG 2 -- int10--------
    rs3762519071,2
    C--26925467(+) AACTT-/CTTTTT 2 -- int10--------
    rs351988871,2
    C--26953094(+) CTGCT-/G/GT  
            
    TTTTT
    2 -- int11NA 2
    rs2021696391,2
    --26953096(+) TGTTT-/GTTTTT 2 -- int10--------
    rs1478623461,2
    C--26953135(+) CTTTT-/ATCTTTTT 2 -- int10--------
    rs346491291,2
    C--26953147(+) TTTTT-/TT    
       
    /TTTT
    TTTTT
    2 -- int11NA 2
    rs672038461,2
    C,F--26959865(+) AAAAAG/AAAGAA 2 -- int12Minor allele frequency- A:0.50CSA 4
    rs2003637911,2
    --26961079(+) TATTT-/ATTTTT 2 -- int10--------

    HapMap Linkage Disequilibrium report for FZD3 (28351722 - 28431785 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FZD3: --

    Human Gene Mutation Database (HGMD): FZD3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FZD3
    DNA2.0 Custom Variant and Variant Library Synthesis for FZD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606143    OMIM disorders: --

    12 diseases for FZD3:    About MalaCards
    schizophrenia    strabismus    williams syndrome    neural tube defects
    mood disorder    basal cell carcinoma    glioblastoma    colorectal cancer
    prostate cancer    prostatitis    endotheliitis    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for FZD3:
    substance-induced psychosis     Schizophrenia

    FZD3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for FZD3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 47.8 13 16707163 (5), 14642436 (3), 15657645 (2), 15288446 (1)

    Genetic Association Database (GAD): FZD3
    Human Genome Epidemiology (HuGE) Navigator: FZD3 (14 documents)

    Export disorders for FZD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FZD3 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with FZD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21. (PubMed id 10777673)1, 2, 3, 9 Kirikoshi H.... Katoh M. (2000)
    2. Identification, gene structure and expression of human frizzled-3 (FZD3). (PubMed id 10873558)1, 2, 3 Sala C.F.... Caricasole A. (2000)
    3. Investigation of genetic association between human Frizzled homolog 3 gene (FZD3) and schizophrenia: results in a Korean population and evidence from meta-analysis. (PubMed id 16707163)1, 4, 9 Jeong S.H....Kim Y.S. (2006)
    4. The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia. (PubMed id 14642436)1, 4, 9 Katsu T....Kuroda S. (2003)
    5. Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders. (PubMed id 15657645)1, 4, 9 Hashimoto R....Kunugi H. (2005)
    6. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (2010)
    7. Pathway-based approaches to imaging genetics associat ion studies: Wnt signaling, GSK3beta substrates and major depression. (PubMed id 20219685)1, 4 Inkster B....Matthews P.M. (2010)
    8. Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. (PubMed id 19054571)1, 4 GregA^rio S.P....Dias-Neto E. (2009)
    9. Two-stage designs to identify the effects of SNP combinations on complex diseases. (PubMed id 18584117)1, 4 Kang G....Zhang D. (2008)
    10. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. (PubMed id 18583979)1, 4 Allen N.C....Bertram L. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7976 HGNC: 4041 AceView: FZD3 Ensembl:ENSG00000104290 euGenes: HUgn7976
    ECgene: FZD3 Kegg: 7976 H-InvDB: FZD3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FZD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FZD3 gene:
    Search GeneIP for patents involving FZD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for FZD3 (Frizzled-3)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     cDNA Clones for FZD3 (Frizzled-3)   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FZD3  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FZD3  
     OriGene qSTAR qPCR primer pairs in human, mouse for FZD3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FZD3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FZD3   OriGene Custom Protein Services for FZD3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FZD3
     QIAGEN SeqTarget long-range PCR primers for resequencing FZD3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FZD3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FZD3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FZD3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FZD3
     GenScript Custom Purified and Recombinant Proteins Services for FZD3 GenScript cDNA clones with any tag delivered in your preferred vector for FZD3
     GenScript Custom Assay Services for FZD3 GenScript Custom Superior Antibodies Services for FZD3
     GenScript Custom overexpressing Cell Line Services for FZD3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FZD3 promoter
     Search Chromatin IP Primers for FZD3
     RT2 qPCR Primer Assay in human, mouse, rat FZD3
     GNC Network for FZD3
     SABiosciences PCR Arrays including human, mouse, rat FZD3
     Search Tocris compounds for FZD3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FZD3 antibodies
     FZD3 proteins
     Antibodies for FZD3
     See all of Abcam's Antibodies, Kits and Proteins for FZD3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for FZD3
     Antibodies for FZD3
     ELISAs for FZD3
     CLIAs for FZD3
     Search LifeMap BioReagents cell lines for FZD3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD3
     SwitchGear 3'UTR luciferase reporter plasmids for FZD3
     SwitchGear Promoter luciferase reporter plasmids for FZD3
     ThermoFisher Antibodies for FZD3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FZD3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FZD3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FZD3
    Customized:
     lentivirus for stable overexpression of FZD3
     lentivirus expression plasmids for stable overexpression of FZD3
     adenovirus for overexpression of FZD3
     LSBio Antibodies in human, mouse, rat for FZD3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FZD3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4