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FZD3 Gene

protein-coding   GIFtS: 66
GCID: GC08P028351

Frizzled Class Receptor 3

(Previous names: frizzled (Drosophila) homolog 3, frizzled homolog 3 (Drosophila),...)
  See FZD3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Frizzled Class Receptor 31 2     Frizzled Homolog 3 (Drosophila)1
Frizzled 3, Seven Transmembrane Spanning Receptor1 2     Frizzled Homolog 32
Frizzled Family Receptor 31 2     frizzled-32
Fz-32 3     hFz33
Frizzled (Drosophila) Homolog 31     

External Ids:    HGNC: 40411   Entrez Gene: 79762   Ensembl: ENSG000001042907   OMIM: 6061435   UniProtKB: Q9NPG13   

Export aliases for FZD3 gene to outside databases

Previous GC identifers: GC08P028134 GC08P028857 GC08P028373 GC08P028407 GC08P026897


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FZD3 Gene:
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain
proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most
frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is
unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in
multiple transcript variants. This gene is a susceptibility locus for schizophrenia. (provided by RefSeq, Dec
2010)

GeneCards Summary for FZD3 Gene:
FZD3 (frizzled class receptor 3) is a protein-coding gene. Diseases associated with FZD3 include substance-induced psychosis, and schizophrenia. GO annotations related to this gene include Wnt-protein binding and G-protein coupled receptor activity. An important paralog of this gene is FZD10.

UniProtKB/Swiss-Prot: FZD3_HUMAN, Q9NPG1
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical
signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear
accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and
calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway
or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of
GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and
intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues

Gene Wiki entry for FZD3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_167187.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FZD3 gene promoter:
         Egr-3   C/EBPbeta   Tal-1beta   E4BP4   GATA-1   YY1   POU2F1   HFH-1   FOXO4   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFZD3 promoter sequence
   Search Chromatin IP Primers for FZD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FZD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21   Ensembl cytogenetic band:  8p21.1   HGNC cytogenetic band: 8p21

FZD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZD3 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P028351:  view genomic region     (about GC identifiers)

Start:
28,351,722 bp from pter      End:
28,431,785 bp from pter
Size:
80,064 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FZD3_HUMAN, Q9NPG1 (See protein sequence)
Recommended Name: Frizzled-3 precursor  
Size: 666 amino acids; 76263 Da
Subunit: Interacts with VANGL2 (By similarity)
Alternative splicing: 2 isoforms:  Q9NPG1-1   Q9NPG1-2   

Explore the universe of human proteins at neXtProt for FZD3: NX_Q9NPG1

Explore proteomics data for FZD3 at MOPED

Post-translational modifications: 

  • Ubiquitinated by ZNRF3, leading to its degradation by the proteasome (By similarity)1
  • Glycosylation2 at Asn42, Asn265, Asn356
  • Modification sites at PhosphoSitePlus

  • See FZD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_059108.1  NP_665873.1  

    ENSEMBL proteins: 
     ENSP00000430125   ENSP00000240093   ENSP00000437489  
    Reactome Protein details: Q9NPG1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FZD: GPCR / Class F : Frizzled receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: FZD3
    Frizzled Class GPCRs

    5 InterPro protein domains:
     IPR000539 Frizzled
     IPR020067 Frizzled_dom
     IPR026553 FZD3_chordata
     IPR015526 Frizzled/SFRP
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry Q9NPG1

    ProtoNet protein and cluster: Q9NPG1

    1 Blocks protein domain: IPB000539 Frizzled protein signature

    UniProtKB/Swiss-Prot: FZD3_HUMAN, Q9NPG1
    Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in
    the activation of the Wnt/beta-catenin signaling pathway (By similarity)
    Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
    Similarity: Belongs to the G-protein coupled receptor Fz/Smo family
    Similarity: Contains 1 FZ (frizzled) domain


    Find genes that share domains with FZD3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FZD3_HUMAN, Q9NPG1
    Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical
    signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear
    accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and
    calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway
    or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of
    GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and
    intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005515protein binding IPI19277043
    GO:0017147Wnt-protein binding IPI19038973
    GO:0030165PDZ domain binding IPI18256285
         
    Find genes that share ontologies with FZD3           About GenesLikeMe


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fzd3):
     behavior/neurological  cellular  embryogenesis  growth/size/body  hearing/vestibular/ear 
     homeostasis/metabolism  limbs/digits/tail  mortality/aging  nervous system  reproductive system 
     respiratory system  vision/eye 

    Find genes that share phenotypes with FZD3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FZD3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FZD3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FZD3
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    miRNA
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    hsa-mir-31-5p (MIRT004984), hsa-mir-98-5p (MIRT027778)

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    Selected qRT-PCR Assays for microRNAs that regulate FZD3 (see all 186):
    hsa-miR-411* hsa-miR-579 hsa-miR-361-5p hsa-miR-640 hsa-miR-106a hsa-miR-128 hsa-miR-759 hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidFZD3 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FZD3_HUMAN, Q9NPG1: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA19038973
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0016324apical plasma membrane IEA--

    Find genes that share ontologies with FZD3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FZD3 About   (see all 24)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathways0.40
    2beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Ca2+ pathway0.43
    Signaling by Wnt0.79
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    4CDK-mediated phosphorylation and removal of Cdc6
    Asymmetric localization of PCP proteins0.75
    PCP/CE pathway0.70
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    GSK3 Signaling0.61


    Find genes that share SuperPaths with FZD3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for FZD3
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FZD3 (see all 11)
        Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Colorectal Cancer Metastasis
    Glioblastoma Multiforme

    2 GeneGo (Thomson Reuters) Pathways for FZD3
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    3 BioSystems Pathways for FZD3
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    Neural Crest Differentiation

    4 Reactome Pathways for FZD3
        Asymmetric localization of PCP proteins
    PCP/CE pathway
    Ca2+ pathway
    Class B/2 (Secretin family receptors)


    Selected Kegg Pathways  (Kegg details for FZD3) (see all 8):
        Wnt signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection
    Pathways in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FZD3: 
              G Protein Coupled Receptors 384HT in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FZD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FZD3 (Q9NPG13 ENSP000002400934) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GIPC2Q8TF653, ENSP000003597954I2D: score=1 STRING: ENSP00000359795
    WNT1P046283, ENSP000002935494I2D: score=1 STRING: ENSP00000293549
    GIPC1O149083, ENSP000003406984I2D: score=1 STRING: ENSP00000340698
    GIPC3Q8TF643, ENSP000003192544I2D: score=1 STRING: ENSP00000319254
    DVL1ENSP000003681694STRING: ENSP00000368169
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001736establishment of planar polarity IBA--
    GO:0001764neuron migration IEA--
    GO:0001843neural tube closure IBA--
    GO:0001942hair follicle development IEA--
    GO:0001944vasculature development IBA--

    Find genes that share ontologies with FZD3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FZD3

    1 HMDB Compound for FZD3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FZD3 gene (2 alternative transcripts): 
    NM_017412.3  NM_145866.1  

    Unigene Cluster for FZD3:

    Frizzled family receptor 3
    Hs.40735  [show with all ESTs]
    Unigene Representative Sequence: NM_017412
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000523546 ENST00000240093(uc003xgx.3 uc010lvb.3) ENST00000517911
    ENST00000537916
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FZD3 (see all 186):
    hsa-miR-411* hsa-miR-579 hsa-miR-361-5p hsa-miR-640 hsa-miR-106a hsa-miR-128 hsa-miR-759 hsa-miR-3622b-3p
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      QuantiTect SYBR Green Assays in human, mouse, rat FZD3
      QuantiFast Probe-based Assays in human, mouse, rat FZD3

    Additional mRNA sequence: 

    AB039723.1 AJ272427.1 AK291480.1 AY005130.3 BC034278.1 BC042009.1 

    8 DOTS entries:

    DT.311096  DT.40278282  DT.213415  DT.40111614  DT.40274870  DT.120643797  DT.86837570  DT.91749033 

    Selected AceView cDNA sequences (see all 41):

    AI261609 AY005130 AJ272427 BM471082 AB039723 BE464229 BC034278 CF147250 
    NM_017412 AW301180 AI708706 AA035080 H41349 AA436403 BM558534 AA897676 
    AL527948 AI352494 H84795 AW294684 CF243017 AA481346 BG697895 AI580985 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FZD3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                                  


    ECgene alternative splicing isoforms for FZD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    FZD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATCAATCA
    FZD3 Expression
    About this image


    FZD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             Human embryonic stem cells (family)
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Midbrain tegmentum
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             Liver Bud
    FZD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FZD3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.40735

    UniProtKB/Swiss-Prot: FZD3_HUMAN, Q9NPG1
    Tissue specificity: Widely expressed. Relatively high expression in the CNS, including regions of the limbic
    system, in kidney, pancreas, skeletal muscle, uterus and testis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FZD3: 
              G Protein Coupled Receptors 384HT in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FZD3
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    QuantiFast Probe-based Assays in human, mouse, rat FZD3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for FZD3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fzd31 , 5 frizzled homolog 3 (Drosophila)1, 5 92.24(n)1
    98.2(a)1
      14 (34.09 cM)5
    143651  NM_021458.21  NP_067433.11 
     652010265 
    chicken
    (Gallus gallus)
    Aves FZD31 frizzled family receptor 3 82.08(n)
    94.29(a)
      395572  NM_001271941.1  NP_001258870.1 
    lizard
    (Anolis carolinensis)
    Reptilia FZD36
    frizzled family receptor 3
    92(a)
    1 ↔ 1
    GL343529.1(74398-126070)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.11862 Xenopus laevis mRNA for frizzled 3 protein 79.09(n)    AJ001754.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fzd3a1 frizzled homolog 3a 68.12(n)
    76.28(a)
      565921  NM_001042761.2  NP_001036226.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fz33 establishment and/or maintenance of
    cell polarity more
    26(a)   1C4   --


    ENSEMBL Gene Tree for FZD3 (if available)
    TreeFam Gene Tree for FZD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FZD3 gene
    FZD102  FZD82  FZD12  FZD52  FZD22  FZD92  SFRP42  SMO2  
    FZD42  FZD62  SFRP12  FRZB2  FZD72  SFRP52  SFRP22  
    9 SIMAP similar genes for FZD3 using alignment to 2 protein entries:     FZD3_HUMAN (see all proteins):
    GPCR    FZD6    FZD1    FZD2    FZD7    FZD10
    FZD5    FZD9    FZD4

    Find genes that share paralogs with FZD3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FZD3 (see all 1632)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1467040331,2
    C--26911201(+) TTTTT-/TTAAGGG 2 -- int10--------
    rs3762519071,2
    C--26925467(+) AACTT-/CTTTTT 2 -- int10--------
    rs351988871,2
    C--26953094(+) CTGCT-/G/GT  
            
    TTTTT
    2 -- int11NA 2
    rs2021696391,2
    --26953096(+) TGTTT-/GTTTTT 2 -- int10--------
    rs1478623461,2
    C--26953135(+) CTTTT-/ATCTTTTT 2 -- int10--------
    rs346491291,2
    C--26953147(+) TTTTT-/TT    
       
    /TTTT
    TTTTT
    2 -- int11NA 2
    rs672038461,2
    C,F--26959865(+) AAAAAG/AAAGAA 2 -- int12Minor allele frequency- A:0.50CSA 4
    rs2003637911,2
    --26961079(+) TATTT-/ATTTTT 2 -- int10--------
    rs667744181,2
    C--26962871(+) GTATT-/CTTTTG 2 -- int10--------
    rs350450291,2
    C--26967106(+) AAAAA-/A/AA  
            
    GCGCT
    4 -- ut311NA 2

    HapMap Linkage Disequilibrium report for FZD3 (28351722 - 28431785 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FZD3: --
    Human Gene Mutation Database (HGMD): FZD3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FZD3
    DNA2.0 Custom Variant and Variant Library Synthesis for FZD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606143    OMIM disorders: --

    2 diseases for FZD3:    
    About MalaCards
    substance-induced psychosis    schizophrenia

    2 diseases from the University of Copenhagen DISEASES database for FZD3:
    substance-induced psychosis     Schizophrenia

    Find genes that share disorders with FZD3           About GenesLikeMe

    1 Novoseek inferred disease relationship for FZD3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 47.8 13 16707163 (5), 14642436 (3), 15657645 (2), 15288446 (1)

    Genetic Association Database (GAD): FZD3
    Human Genome Epidemiology (HuGE) Navigator: FZD3 (14 documents)

    Export disorders for FZD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FZD3 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with FZD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21. (PubMed id 10777673)1, 2, 3, 9 Kirikoshi H.... Katoh M. (Biochem. Biophys. Res. Commun. 2000)
    2. Identification, gene structure and expression of human frizzled-3 (FZD3). (PubMed id 10873558)1, 2, 3 Sala C.F.... Caricasole A. (Biochem. Biophys. Res. Commun. 2000)
    3. Investigation of genetic association between human Frizzled homolog 3 gene (FZD3) and schizophrenia: results in a Korean population and evidence from meta-analysis. (PubMed id 16707163)1, 4, 9 Jeong S.H....Kim Y.S. (Psychiatry Res 2006)
    4. The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia. (PubMed id 14642436)1, 4, 9 Katsu T....Kuroda S. (Neurosci. Lett. 2003)
    5. Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders. (PubMed id 15657645)1, 4, 9 Hashimoto R....Kunugi H. (J Neural Transm 2005)
    6. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    7. Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression. (PubMed id 20219685)1, 4 Inkster B....Matthews P.M. (Neuroimage 2010)
    8. Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. (PubMed id 19054571)1, 4 GregA^rio S.P....Dias-Neto E. (Psychiatry Res 2009)
    9. Two-stage designs to identify the effects of SNP combinations on complex diseases. (PubMed id 18584117)1, 4 Kang G....Zhang D. (J. Hum. Genet. 2008)
    10. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. (PubMed id 18583979)1, 4 Allen N.C....Bertram L. (Nat. Genet. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7976 HGNC: 4041 AceView: FZD3 Ensembl:ENSG00000104290 euGenes: HUgn7976
    ECgene: FZD3 Kegg: 7976 H-InvDB: FZD3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FZD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FZD3 gene:
    Search GeneIP for patents involving FZD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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