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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FZD3 Gene

protein-coding GIFtS: 63
GCID: GC08P028351

frizzled family receptor 3

(Previous names: frizzled (Drosophila) homolog 3, frizzled homolog 3 (Drosophila),...)

Explore 12 diseases affiliated with
FZD3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Frizzled Family Receptor 3¹ ²		Frizzled Homolog 3 (Drosophila)¹
Frizzled 3, Seven Transmembrane Spanning Receptor¹ ²		Frizzled Homolog 3²
Fz-3² ³		Frizzled-3¹
Frizzled (Drosophila) Homolog 3¹		HFz3¹

External Ids:	HGNC: 4041¹	Entrez Gene: 7976²	Ensembl: ENSG00000104290⁷	OMIM: 606143⁵	UniProtKB: Q9NPG1³

Export aliases for FZD3 gene to outside databases

Previous GC identifers: GC08P028134 GC08P028857 GC08P028373 GC08P028407 GC08P026897

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FZD3:

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins

that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors

are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may

play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This

gene is a susceptibility locus for schizophrenia. (provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: FZD3_HUMAN, Q9NPG1

Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling

pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of

beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been

seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated

in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways

seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of

polarity information during tissue morphogenesis and/or in differentiated tissues

Gene Wiki entry for FZD3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_167187.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FZD3 gene promoter:
Egr-3 C/EBPbeta Tal-1beta E4BP4 GATA-1 YY1 POU2F1 HFH-1 FOXO4 ITF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FZD3 promoter sequence

Search SABiosciences Chromatin IP Primers for FZD3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FZD3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21 Ensembl cytogenetic band: 8p21.1 HGNC cytogenetic band: 8p21

FZD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZD3 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P028351: view genomic region (about GC identifiers)

Start:	28,351,729 bp from pter	End:	28,431,775 bp from pter
Size:	80,047 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FZD3_HUMAN, Q9NPG1 (See protein sequence)

Recommended Name: Frizzled-3 precursor

Size: 666 amino acids; 76263 Da

Subunit: Interacts with VANGL2 (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By similarity)

Alternative splicing: 2 isoforms: Q9NPG1-1 Q9NPG1-2

Explore the universe of human proteins at neXtProt for FZD3: NX_Q9NPG1

Post-translational modifications:

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NPG1

FZD3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_059108.1 NP_665873.1

ENSEMBL proteins:

ENSP00000430125 ENSP00000240093 ENSP00000437489

Reactome Protein details: Q9NPG1
Human Recombinant Protein Products:

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	Novus Biologicals FZD3 Protein
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	Uscn Proteins for FZD3

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	19038973
GO:0005886	plasma membrane	IDA	19038973
GO:0016021	integral to membrane	IEA	--
GO:0016324	apical plasma membrane	IEA	--
GO:0030424	axon	IBA	--

FZD3 for ontologies About GeneDecksing

FZD3 Antibody Products:

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Assay Products for FZD3:

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	Uscn ELISAs and CLIAs for FZD3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FZD3 for domains About GeneDecksing

5 InterPro domains/families:

IPR000539 Frizzled

IPR020067 Frizzled_dom

IPR026553 FZD3_chordata

IPR015526 Frizzled/SFRP

IPR017981 GPCR_2-like

Graphical View of Domain Structure for InterPro Entry Q9NPG1

ProtoNet protein and cluster: Q9NPG1

1 Blocks protein family: IPB000539 Frizzled protein signature

UniProtKB/Swiss-Prot: FZD3_HUMAN, Q9NPG1

Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the

activation of the Wnt/beta-catenin signaling pathway (By similarity)

Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)

Similarity: Belongs to the G-protein coupled receptor Fz/Smo family

Similarity: Contains 1 FZ (frizzled) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FZD3_HUMAN, Q9NPG1

Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling

pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of

beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been

seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated

in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways

seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of

polarity information during tissue morphogenesis and/or in differentiated tissues

miRNA Products:		miRTarBase miRNAs that target FZD3: hsa-mir-31 (MIRT004984)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FZD3
		8/186 QIAGEN miScript miRNA Assays for microRNAs that regulate FZD3 (see all 186):
		hsa-miR-411* hsa-miR-579 hsa-miR-361-5p hsa-miR-640 hsa-miR-106a hsa-miR-128 hsa-miR-759 hsa-miR-3622b-3p

		SwitchGear 3'UTR luciferase reporter plasmid: FZD3 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD3

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0005515	protein binding	IPI	19277043
GO:0017147	Wnt-protein binding	IPI	19038973
GO:0030165	PDZ domain binding	IPI	18256285
GO:0042813	Wnt-activated receptor activity	IC	19038973

FZD3 for ontologies About GeneDecksing

Animal Models:
12 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fzd3):

behavior/neurological	cellular	embryogenesis	growth/size	hearing/vestibular/ear
homeostasis/metabolism	limbs/digits/tail	mortality/aging	nervous system	reproductive system
respiratory system	vision/eye

FZD3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Wnt Signaling Pathway

	Wnt Signaling Pathway	1.00			Wnt Signaling Pathway	0.33
	Wnt Signaling Pathway and Pluripotency	0.55			Wnt signaling pathway	0.30

Translation_Non-genomic (rapid) action of Androgen Receptor

Translation_Non-genomic (rapid) action of Androgen Receptor

1.00

Translation Non-genomic (rapid) action of Androgen Receptor

0.99

Transcription_Androgen Receptor nuclear signaling

Transcription_Androgen Receptor nuclear signaling

1.00

Transcription Androgen Receptor nuclear signaling

0.99

Nanog in Mammalian ESC Pluripotency

Nanog in Mammalian ESC Pluripotency

1.00

GSK3 Signaling

0.61

Human Embryonic Stem Cell Pluripotency

Human Embryonic Stem Cell Pluripotency

1.00

Factors Promoting Cardiogenesis in Vertebrates

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for FZD3

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

1 R&D Systems Pathway for FZD3

Wnt Signaling Pathway

5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FZD3 (see all 11)

	Factors Promoting Cardiogenesis in Vertebrates
	Molecular Mechanisms of Cancer
	G12-G13 in Cellular Signaling
	Colorectal Cancer Metastasis
	Glioblastoma Multiforme

2 GeneGo (Thomson Reuters) Pathways for FZD3

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

3 BioSystems Pathways for FZD3

	Wnt Signaling Pathway and Pluripotency
	Neural Crest Differentiation
	Wnt Signaling Pathway

4 Reactome Pathways for FZD3

	Signal Transduction
	Signaling by GPCR
	GPCR ligand binding
	Class B/2 (Secretin family receptors)

4 Kegg Pathways (Kegg details for FZD3):

	Wnt signaling pathway
	Melanogenesis
	Pathways in cancer
	Basal cell carcinoma

FZD3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FZD3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/38 Interacting proteins for FZD3 (Q9NPG1³ ENSP00000240093⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GIPC2	Q8TF65³, ENSP00000359795⁴	I2D: score=1 STRING: ENSP00000359795
WNT1	P04628³, ENSP00000293549⁴	I2D: score=1 STRING: ENSP00000293549
GIPC1	O14908³, ENSP00000340698⁴	I2D: score=1 STRING: ENSP00000340698
GIPC3	Q8TF64³, ENSP00000319254⁴	I2D: score=1 STRING: ENSP00000319254
DVL1	ENSP00000368169⁴	STRING: ENSP00000368169

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001736	establishment of planar polarity	IBA	--
GO:0001764	neuron migration	IEA	--
GO:0001843	neural tube closure	IBA	--
GO:0001942	hair follicle development	IEA	--
GO:0001944	vasculature development	IBA	--

FZD3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FZD3

1 HMDB Compound for FZD3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about FZD3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FZD3 gene (2 alternative transcripts):

NM_017412.3 NM_145866.1

Unigene Cluster for FZD3:

Frizzled family receptor 3

Hs.40735 [show with all ESTs]

Unigene Representative Sequence: NM_017412

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000523546 ENST00000240093(uc003xgx.3 uc010lvb.3) ENST00000517911

ENST00000537916

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FZD3
		8/186 QIAGEN miScript miRNA Assays for microRNAs that regulate FZD3 (see all 186):
		hsa-miR-411* hsa-miR-579 hsa-miR-361-5p hsa-miR-640 hsa-miR-106a hsa-miR-128 hsa-miR-759 hsa-miR-3622b-3p

		SwitchGear 3'UTR luciferase reporter plasmid: FZD3 3' UTR sequence

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Additional cDNA sequence:

AB039723.1 AJ272427.1 AK291480.1 AY005130.3 BC034278.1 BC042009.1

8 DOTS entries:

DT.311096 DT.40278282 DT.213415 DT.40111614 DT.40274870 DT.120643797 DT.86837570 DT.91749033

24/41 AceView cDNA sequences (see all 41):

BE464229 AI261609 BM471082 AW301180 BC034278 AB039723 NM_017412 AY005130

CF147250 AJ272427 CF243017 AI708706 AI352494 BM558534 BU187770 AA897676

AW294684 AA224023 AI580985 H84795 AA436403 AA481346 BX280696 H41349

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for FZD3 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7	^	8
SP1:
SP2:
SP3:
SP4:

ECgene alternative splicing isoforms for FZD3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FZD3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATCAATCA

About this image

FZD3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Brain

Liver

Diencephalic Ventricular Zone

Neural Tube

Diencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FZD3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FZD3

SOURCE GeneReport for Unigene cluster: Hs.40735

UniProtKB/Swiss-Prot: FZD3_HUMAN, Q9NPG1

Tissue specificity: Widely expressed. Relatively high expression in the CNS, including regions of the limbic system, in

kidney, pancreas, skeletal muscle, uterus and testis

SABiosciences Expression via Pathway-Focused PCR Arrays including FZD3:

G Protein Coupled Receptors 384HT in human mouse rat

WNT Signaling Pathway in human mouse rat

Stem Cell Signaling in human mouse rat

Notch Signaling Pathway in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FZD3 gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FZD3¹	frizzled family receptor 3	82.08(n) 94.29(a)		395572 XM_420029.3 XP_420029.2
lizard (Anolis carolinensis)	Reptilia	FZD3⁶	--	92(a)	1 ↔ 1	GL343529.1(88496-124332)
African clawed frog (Xenopus laevis)	Amphibia	Xl.1186²	Xenopus laevis mRNA for frizzled 3 protein	79.09(n)		AJ001754.1
zebrafish (Danio rerio)	Actinopterygii	fzd3a¹	frizzled homolog 3a	68.22(n) 76.28(a)		565921 NM_001042761.2 NP_001036226.1

ENSEMBL Gene Tree for FZD3 (if available)
TreeFam Gene Tree for FZD3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FZD3 gene

FZD10² FZD8² FZD1² FZD5² FZD2² FZD9² SFRP4² SMO²

FZD4² FZD6² SFRP1² FRZB² FZD7² SFRP5² SFRP2²

10 SIMAP similar genes for FZD3 using alignment to 2 protein entries: FZD3_HUMAN (see all proteins):

GPCR FZD6 FZD1 FZD2 FZD7 FZD10

FZD5 FZD9 FZD4 FZD8

FZD3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs80091803^1,2	C,	--	26895195(+)	`GCTGGG/TATTAC`	2	--	us2k¹		2		CSA WA	120
rs74613217^1,2		--	26895846(+)	`TGCCCC/TGCCTA`	2	--	us2k¹		0	--	--	--	--
rs112777339^1,2		--	26895963(+)	`TCACAC/GAGTTC`	2	--	us2k¹		2		CSA WA	120
rs7841079^1,2	C,	--	26897496(+)	`TTCGCT/CCGCCT`	2	--	int¹		4		NA WA	242
rs28561077^1,2		--	26897628(+)	`CGCGCC/TGCCAG`	2	--	int¹		0	--	--	--	--
rs75654528^1,2		--	26897721(+)	`GCAAAC/GTCCTT`	2	--	int¹		0	--	--	--	--
rs6558066^1,2	C,F,A,H,	--	26898029(+)	`CAGATT/ATAGAG`	2	--	int¹		15		NS EA NA WA	1640
rs10097593^1,2	C,	--	26898251(+)	`AAGCCA/GATATG`	2	--	int¹		2		WA	120
rs7842256^1,2	C,F,A,H,	--	26898525(+)	`AGCCTA/CGGAAA`	2	--	int¹ trp³		9		NS NA WA	1028
rs7824052^1,2	C,	--	26898896(+)	`GAGAGG/TGCTAG`	2	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FZD3 (28351729 - 28431775 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FZD3: --
Human Gene Mutation Database (HGMD): FZD3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FZD3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FZD3 for disorders           About GeneDecksing

OMIM gene information: 606143    OMIM disorders: --

12 diseases for FZD3:    About MalaCards

neural tube defect schizophrenia basal cell carcinoma mood disorder

strabismus williams syndrome prostate cancer prostatitis

carcinoma neuronitis colorectal cancer glioblastoma

2 diseases from the University of Copenhagen DISEASES database for FZD3:

substance-induced psychosis Schizophrenia

1 Novoseek disease relationship for FZD3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
schizophrenia	47.8	13	16707163 (5), 14642436 (3), 15657645 (2), 15288446 (1)

Genetic Association Database (GAD): FZD3
Human Genome Epidemiology (HuGE) Navigator: FZD3 (14 documents)

Export disorders for FZD3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FZD3 gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with FZD3)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21. (PubMed id 10777673)^{1, 2, 3, 9} Kirikoshi H.... Katoh M. (2000)
Identification, gene structure and expression of human frizzled-3 (FZD3). (PubMed id 10873558)^{1, 2, 3} Sala C.F.... Caricasole A. (2000)
The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia. (PubMed id 14642436)^{1, 4, 9} Katsu T....Kuroda S. (2003)
Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders. (PubMed id 15657645)^{1, 4, 9} Hashimoto R....Kunugi H. (2005)
Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population. (PubMed id 15274031)^{1, 4} Zhang Y....Zhang D. (2004)
Genetic and expression analyses of FZD3 in schizophrenia. (PubMed id 15364045)^{1, 4} Ide M....Yoshikawa T. (2004)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
Characterization of mouse frizzled-3 expression in hair follicle development and identification of the human homolog in keratinocytes. (PubMed id 11407985)^{1, 2} Hung B.S.... Rothnagel J.A. (2001)
Investigation of genetic association between human Frizzled homolog 3 gene (FZD3) and schizophrenia: results in a Korean population and evidence from meta-analysis. (PubMed id 16707163)^{1, 9} Jeong S.H....Kim Y.S. (2006)
Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism. (PubMed id 18212053)^{1, 9} Endo Y....Rubin J.S. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7976	HGNC: 4041	AceView: FZD3	Ensembl:ENSG00000104290	euGenes: HUgn7976
ECgene: FZD3	Kegg: 7976	H-InvDB: FZD3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FZD3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FZD3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FZD3 gene:
Search GeneIP for patents involving FZD3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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frizzled family receptor 3

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