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Aliases for FZD3 Gene

Aliases for FZD3 Gene

  • Frizzled Class Receptor 3 2 3 5
  • Frizzled 3, Seven Transmembrane Spanning Receptor 2 3
  • Frizzled Family Receptor 3 2 3
  • Fz-3 3 4
  • Frizzled (Drosophila) Homolog 3 2
  • Frizzled Homolog 3 (Drosophila) 2
  • Frizzled Homolog 3 3
  • Frizzled-3 3
  • HFz3 4

External Ids for FZD3 Gene

Previous GeneCards Identifiers for FZD3 Gene

  • GC08P028134
  • GC08P028857
  • GC08P028373
  • GC08P028407
  • GC08P026897
  • GC08P028351

Summaries for FZD3 Gene

Entrez Gene Summary for FZD3 Gene

  • This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]

GeneCards Summary for FZD3 Gene

FZD3 (Frizzled Class Receptor 3) is a Protein Coding gene. Diseases associated with FZD3 include Substance-Induced Psychosis and Congenital Hydrocephalus. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-independent Wnt/Ca2+ Signaling and Other Non-canonical Wnt Signaling Pathways and Transcription Androgen Receptor nuclear signaling. GO annotations related to this gene include G-protein coupled receptor activity and PDZ domain binding. An important paralog of this gene is FZD6.

UniProtKB/Swiss-Prot for FZD3 Gene

  • Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner (By similarity).

Gene Wiki entry for FZD3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FZD3 Gene

Genomics for FZD3 Gene

Regulatory Elements for FZD3 Gene

Enhancers for FZD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G028398 1.8 FANTOM5 ENCODE dbSUPER 20 -93.2 -93195 5.0 MLX FEZF1 DMAP1 SLC30A9 ZNF548 ZNF263 SP3 SSRP1 ZNF610 GLIS1 FZD3 ENSG00000259366 ENSG00000253567 HMBOX1 ZNF395 PIR39512
GH08G028363 1.6 Ensembl ENCODE dbSUPER 17.8 -124.3 -124305 13.8 HDGF PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF143 FZD3 FBXO16 ZNF395 ENSG00000253690 PNOC ENSG00000259366 PIR39512
GH08G028657 1.3 Ensembl ENCODE 21.2 +163.8 163849 1.7 FOXA2 ARID4B SIN3A FEZF1 ZNF2 YY1 ETS1 ZNF121 ZNF766 GLIS2 FZD3 GC08P028669 LOC105379345
GH08G028515 1.1 Ensembl ENCODE 24.8 +21.3 21292 0.7 NFIB ARID4B DMAP1 FEZF1 ZNF2 ZNF48 YY1 ZNF121 ZNF366 ZSCAN5C FZD3 MIR4288 GC08P028531
GH08G028346 1.4 Ensembl ENCODE dbSUPER 16.5 -144.1 -144070 7.9 TBP HDGF PKNOX1 SIN3A ZBTB7B ZBTB40 TCF12 ZNF121 ZNF766 EGR1 FZD3 FBXO16 EXTL3 NUGGC PNOC PIR39512 ZNF395
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FZD3 on UCSC Golden Path with GeneCards custom track

Promoters for FZD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000222775 195 1601 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B ZNF766 ZNF143 ZNF207 FOS

Genomic Location for FZD3 Gene

Chromosome:
8
Start:
28,494,205 bp from pter
End:
28,574,268 bp from pter
Size:
80,064 bases
Orientation:
Plus strand

Genomic View for FZD3 Gene

Genes around FZD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FZD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FZD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FZD3 Gene

Proteins for FZD3 Gene

  • Protein details for FZD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPG1-FZD3_HUMAN
    Recommended name:
    Frizzled-3
    Protein Accession:
    Q9NPG1
    Secondary Accessions:
    • A8K615

    Protein attributes for FZD3 Gene

    Size:
    666 amino acids
    Molecular mass:
    76263 Da
    Quaternary structure:
    • Interacts with VANGL2.

    Alternative splice isoforms for FZD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FZD3 Gene

Post-translational modifications for FZD3 Gene

  • Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
  • Glycosylation at Asn42, isoforms=265, and Asn356
  • Modification sites at PhosphoSitePlus

Other Protein References for FZD3 Gene

No data available for DME Specific Peptides for FZD3 Gene

Domains & Families for FZD3 Gene

Gene Families for FZD3 Gene

Suggested Antigen Peptide Sequences for FZD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPG1

UniProtKB/Swiss-Prot:

FZD3_HUMAN :
  • Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
  • Belongs to the G-protein coupled receptor Fz/Smo family.
Domain:
  • Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
  • The FZ domain is involved in binding with Wnt ligands.
Family:
  • Belongs to the G-protein coupled receptor Fz/Smo family.
genes like me logo Genes that share domains with FZD3: view

Function for FZD3 Gene

Molecular function for FZD3 Gene

UniProtKB/Swiss-Prot Function:
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner (By similarity).

Gene Ontology (GO) - Molecular Function for FZD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005515 protein binding IPI 19277043
GO:0017147 Wnt-protein binding NAS 24431302
genes like me logo Genes that share ontologies with FZD3: view
genes like me logo Genes that share phenotypes with FZD3: view

Animal Models for FZD3 Gene

MGI Knock Outs for FZD3:

Animal Model Products

  • Taconic Biosciences Mouse Models for FZD3

miRNA for FZD3 Gene

miRTarBase miRNAs that target FZD3

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FZD3 Gene

Localization for FZD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FZD3 Gene

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell surface. Apical cell membrane; Multi-pass membrane protein. Note=Colocalizes with FZD6 at the apical face of the cell (By similarity). {ECO:0000250 UniProtKB:Q61086}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FZD3 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for FZD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19038973
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FZD3: view

Pathways & Interactions for FZD3 Gene

genes like me logo Genes that share pathways with FZD3: view

SIGNOR curated interactions for FZD3 Gene

Gene Ontology (GO) - Biological Process for FZD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001736 establishment of planar polarity IEA --
GO:0001764 neuron migration IEA --
GO:0001843 neural tube closure IEA --
GO:0001942 hair follicle development IEA --
GO:0002052 positive regulation of neuroblast proliferation IEA,ISS --
genes like me logo Genes that share ontologies with FZD3: view

Drugs & Compounds for FZD3 Gene

(1) Drugs for FZD3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with FZD3: view

Transcripts for FZD3 Gene

Unigene Clusters for FZD3 Gene

Frizzled family receptor 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FZD3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2:
SP3:
SP4:

Relevant External Links for FZD3 Gene

GeneLoc Exon Structure for
FZD3
ECgene alternative splicing isoforms for
FZD3

Expression for FZD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FZD3 Gene

Protein differential expression in normal tissues from HIPED for FZD3 Gene

This gene is overexpressed in Fetal Brain (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FZD3 Gene



Protein tissue co-expression partners for FZD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FZD3 Gene:

FZD3

SOURCE GeneReport for Unigene cluster for FZD3 Gene:

Hs.40735

mRNA Expression by UniProt/SwissProt for FZD3 Gene:

Q9NPG1-FZD3_HUMAN
Tissue specificity: Widely expressed. Relatively high expression in the CNS, including regions of the limbic system, in kidney, pancreas, skeletal muscle, uterus and testis.

Evidence on tissue expression from TISSUES for FZD3 Gene

  • Nervous system(4.7)
  • Skin(4.3)
genes like me logo Genes that share expression patterns with FZD3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FZD3 Gene

Orthologs for FZD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FZD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FZD3 34 35
  • 99.7 (n)
oppossum
(Monodelphis domestica)
Mammalia FZD3 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FZD3 34 35
  • 95.3 (n)
cow
(Bos Taurus)
Mammalia FZD3 34 35
  • 93.44 (n)
-- 35
  • 75 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fzd3 34
  • 92.49 (n)
mouse
(Mus musculus)
Mammalia Fzd3 34 16 35
  • 92.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FZD3 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves FZD3 34 35
  • 82.08 (n)
lizard
(Anolis carolinensis)
Reptilia FZD3 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fzd3 34
  • 76.33 (n)
Str.2030 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.1186 34
zebrafish
(Danio rerio)
Actinopterygii fzd3b 35
  • 76 (a)
OneToMany
fzd3a 34 35
  • 68.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta fz 35
  • 36 (a)
OneToMany
fz3 36
  • 26 (a)
worm
(Caenorhabditis elegans)
Secernentea mom-5 36
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4359 35
  • 31 (a)
OneToMany
Species where no ortholog for FZD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FZD3 Gene

ENSEMBL:
Gene Tree for FZD3 (if available)
TreeFam:
Gene Tree for FZD3 (if available)

Paralogs for FZD3 Gene

Paralogs for FZD3 Gene

(9) SIMAP similar genes for FZD3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FZD3: view

Variants for FZD3 Gene

Sequence variations from dbSNP and Humsavar for FZD3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000025463 -- 28,555,217(+) CTCGT(A/T)GACTA intron-variant
rs1000049128 -- 28,520,908(+) TTTCC(-/ATCT)GTTTT intron-variant
rs1000068874 -- 28,512,219(+) AAAGA(A/C)AGCAA intron-variant
rs1000072951 -- 28,506,230(+) AATAA(C/T)TGAAC intron-variant, upstream-variant-2KB
rs1000236437 -- 28,557,703(+) TCTAC(A/C)TGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FZD3 Gene

Variant ID Type Subtype PubMed ID
dgv7157n100 CNV loss 25217958
dgv7158n100 CNV loss 25217958
nsv1015224 CNV gain 25217958
nsv1024602 CNV loss 25217958
nsv472793 CNV novel sequence insertion 20440878

Variation tolerance for FZD3 Gene

Residual Variation Intolerance Score: 9.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FZD3 Gene

Human Gene Mutation Database (HGMD)
FZD3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FZD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FZD3 Gene

Disorders for FZD3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for FZD3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
substance-induced psychosis
congenital hydrocephalus
schizophrenia
  • schizophrenia 12
neural tube defects
  • spina bifida
- elite association - COSMIC cancer census association via MalaCards
Search FZD3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FZD3

Genetic Association Database (GAD)
FZD3
Human Genome Epidemiology (HuGE) Navigator
FZD3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FZD3
genes like me logo Genes that share disorders with FZD3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FZD3 Gene

Publications for FZD3 Gene

  1. Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21. (PMID: 10777673) Kirikoshi H. … Katoh M. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 22 64
  2. Investigation of genetic association between human Frizzled homolog 3 gene (FZD3) and schizophrenia: results in a Korean population and evidence from meta-analysis. (PMID: 16707163) Jeong S.H. … Kim Y.S. (Psychiatry Res 2006) 3 22 46 64
  3. Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders. (PMID: 15657645) Hashimoto R. … Kunugi H. (J Neural Transm 2005) 3 22 46 64
  4. The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia. (PMID: 14642436) Katsu T. … Kuroda S. (Neurosci. Lett. 2003) 3 22 46 64
  5. Identification, gene structure and expression of human frizzled-3 (FZD3). (PMID: 10873558) Sala C.F. … Caricasole A. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 64

Products for FZD3 Gene

Sources for FZD3 Gene

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