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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FZD2 Gene

protein-coding GIFtS: 63
GCID: GC17P042645

frizzled family receptor 2

(Previous names: frizzled (Drosophila) homolog 2, frizzled homolog 2 (Drosophila),...)

Explore 10 diseases affiliated with
FZD2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Frizzled Family Receptor 2¹ ²		Frizzled Homolog 2²
Frizzled 2, Seven Transmembrane Spanning Receptor¹ ²		Frizzled-2¹
HFz2¹		Fz-2³
Frizzled (Drosophila) Homolog 2¹		FzE2³
Frizzled Homolog 2 (Drosophila)¹		Fz-2³
Fz2²		FzE2³

External Ids:	HGNC: 4040¹	Entrez Gene: 2535²	Ensembl: ENSG00000180340⁷	OMIM: 600667⁵	UniProtKB: Q14332³

Export aliases for FZD2 gene to outside databases

Previous GC identifers: GC17P042290 GC17P044812 GC17P043109 GC17P043110 GC17P039990 GC17P038404

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FZD2:

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain

proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene

encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the

wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene

products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways.

(provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: FZD2_HUMAN, Q14332

Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling

pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of

beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been

seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated

in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways

seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of

polarity information during tissue morphogenesis and/or in differentiated tissues

Gene Wiki entry for FZD2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FZD2 gene promoter:
CUTL1 AP-2gamma c-Ets-1 POU2F1 FOXO4 COMP1 POU2F1a AP-2beta AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FZD2 promoter sequence

Search SABiosciences Chromatin IP Primers for FZD2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FZD2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.1 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21.1

FZD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZD2 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P042645: view genomic region (about GC identifiers)

Start:	42,634,925 bp from pter	End:	42,636,907 bp from pter
Size:	1,983 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FZD2_HUMAN, Q14332 (See protein sequence)

Recommended Name: Frizzled-2 precursor

Size: 565 amino acids; 63554 Da

Subcellular location: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By similarity)

Secondary accessions: Q0VG82

Explore the universe of human proteins at neXtProt for FZD2: NX_Q14332

Post-translational modifications:

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q14332

FZD2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001457.1

ENSEMBL proteins:

ENSP00000323901

Reactome Protein details: Q14332
Human Recombinant Protein Products:

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	Uscn Proteins for FZD2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	19038973
GO:0005886	plasma membrane	IDA	18929644
GO:0016021	integral to membrane	IEA	--
GO:0032589	neuron projection membrane	IBA	--
GO:0045177	apical part of cell	IBA	--

FZD2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for FZD2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FZD2 for domains About GeneDecksing

5 InterPro domains/families:

IPR000539 Frizzled

IPR020067 Frizzled_dom

IPR015526 Frizzled/SFRP

IPR017981 GPCR_2-like

IPR026550 FZD2

Graphical View of Domain Structure for InterPro Entry Q14332

ProtoNet protein and cluster: Q14332

1 Blocks protein family: IPB000539 Frizzled protein signature

UniProtKB/Swiss-Prot: FZD2_HUMAN, Q14332

Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the

activation of the Wnt/beta-catenin signaling pathway (By similarity)

Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)

Similarity: Belongs to the G-protein coupled receptor Fz/Smo family

Similarity: Contains 1 FZ (frizzled) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FZD2_HUMAN, Q14332

Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling

pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of

beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been

seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated

in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways

seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of

polarity information during tissue morphogenesis and/or in differentiated tissues

Genatlas biochemistry entry for FZD2:

Drosophila frizzled polarity gene homolog,G protein coupled receptor superfamily,exhibiting characteristics of a WNT

receptor,expressed in adult heart,fetal brain,lung and kidney,involved in signal transduction,activating Dishevelled

miRNA Products:		OriGene 3'-UTR Clone: FZD2 Browse MicroRNA Expression Plasmids
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD2

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0005515	protein binding	--	--
GO:0017147	Wnt-protein binding	IBA	--
GO:0030165	PDZ domain binding	IPI	19388021
GO:0042813	Wnt-activated receptor activity	IBA	--

FZD2 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for FZD2:

Decreased BPV1 E2 protein expr

Decreased G3BP1 protein expres

Increased HPV18 LCR reporter a

Synthetic lethal with imatinib

Animal Models:
11 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fzd2):

cardiovascular system	craniofacial	digestive/alimentary	embryogenesis	growth/size
hearing/vestibular/ear	homeostasis/metabolism	mortality/aging	nervous system	skeleton
taste/olfaction

FZD2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Wnt Signaling Pathway

Wnt Signaling Pathway	1.00	Wnt signaling pathway	0.30
Wnt Signaling Pathway and Pluripotency	0.55	Wnt Signaling Pathway NetPath	0.22
Wnt Signaling Pathway	0.33

Translation_Non-genomic (rapid) action of Androgen Receptor

Translation_Non-genomic (rapid) action of Androgen Receptor

1.00

Translation Non-genomic (rapid) action of Androgen Receptor

0.99

Transcription_Androgen Receptor nuclear signaling

Transcription_Androgen Receptor nuclear signaling

1.00

Transcription Androgen Receptor nuclear signaling

0.99

Nanog in Mammalian ESC Pluripotency

Nanog in Mammalian ESC Pluripotency

1.00

GSK3 Signaling

0.61

Human Embryonic Stem Cell Pluripotency

Human Embryonic Stem Cell Pluripotency

1.00

Factors Promoting Cardiogenesis in Vertebrates

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for FZD2

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

1 R&D Systems Pathway for FZD2

Wnt Signaling Pathway

5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FZD2 (see all 11)

	Factors Promoting Cardiogenesis in Vertebrates
	Molecular Mechanisms of Cancer
	G12-G13 in Cellular Signaling
	Colorectal Cancer Metastasis
	Glioblastoma Multiforme

2 GeneGo (Thomson Reuters) Pathways for FZD2

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

5/6 BioSystems Pathways for FZD2 (see all 6)

	MicroRNAs in cardiomyocyte hypertrophy
	Wnt Signaling Pathway and Pluripotency
	Wnt Signaling Pathway
	Wnt Signaling Pathway NetPath
	Noncanonical Wnt signaling pathway

4 Reactome Pathways for FZD2

	Signal Transduction
	Signaling by GPCR
	GPCR ligand binding
	Class B/2 (Secretin family receptors)

4 Kegg Pathways (Kegg details for FZD2):

	Wnt signaling pathway
	Melanogenesis
	Pathways in cancer
	Basal cell carcinoma

FZD2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FZD2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/42 Interacting proteins for FZD2 (Q14332³ ENSP00000323901⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 42)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DLG4	P78352³, ENSP00000293813⁴	I2D: score=3 STRING: ENSP00000293813
ROR2	Q01974³, ENSP00000364860⁴	I2D: score=3 STRING: ENSP00000364860
ARRB2	ENSP00000269260⁴	STRING: ENSP00000269260
DVL2	ENSP00000005340⁴	STRING: ENSP00000005340
LRP6	ENSP00000261349⁴	STRING: ENSP00000261349

About this table

Gene Ontology (GO): 5/30 biological process terms (GO ID links to tree view) (see all 30): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001775	cell activation	--	--
GO:0001944	vasculature development	IBA	--
GO:0003149	membranous septum morphogenesis	IEA	--
GO:0003150	muscular septum morphogenesis	IEA	--
GO:0003151	outflow tract morphogenesis	IEA	--

FZD2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FZD2

1 HMDB Compound for FZD2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about FZD2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FZD2 gene:

NM_001466.3

Unigene Cluster for FZD2:

Frizzled family receptor 2

Hs.142912 [show with all ESTs]

Unigene Representative Sequence: NM_001466

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000315323(uc002igx.2)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FZD2
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate FZD2 (see all 26):
		hsa-miR-3689b hsa-miR-30c hsa-miR-1226 hsa-miR-4328 hsa-miR-520d-5p hsa-miR-522 hsa-miR-30d hsa-miR-410

		SwitchGear 3'UTR luciferase reporter plasmid: FZD2 3' UTR sequence

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Additional cDNA sequence:

AB017364.1 BC052266.1 BC113402.1 BC113404.1 L37882.1

3 DOTS entries:

DT.208046 DT.102824356 DT.95263888

24/69 AceView cDNA sequences (see all 69):

BF512595 BC052266 CF130992 L37882 AA297335 BE392146 BM666204 BC036881

CN484180 AB017364 BQ231687 CA429523 NM_001466 AI860140 AW245391 BU681711

AI858773 BG054704 BX106729 CA390932 AW474898 AI279304 BQ650917 BM927842

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FZD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACGCTCATCG

About this image

FZD2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Outflow Tract

Neural Crest Outflow Tract Cells

Neural Crest

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

See FZD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FZD2

SOURCE GeneReport for Unigene cluster: Hs.142912

UniProtKB/Swiss-Prot: FZD2_HUMAN, Q14332

Tissue specificity: Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung, kidney,

pancreas, prostate, testis, ovary and colon. In the fetus, expressed in brain, lung and kidney. Low levels in fetal

liver

SABiosciences Expression via Pathway-Focused PCR Arrays including FZD2:

G Protein Coupled Receptors 384HT in human mouse rat

WNT Signaling Pathway in human mouse rat

Stem Cell Signaling in human mouse rat

Notch Signaling Pathway in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FZD2 gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FZD2¹	frizzled family receptor 2	88.1(n) 90.58(a)		374061 NM_204222.1 NP_989553.1
lizard (Anolis carolinensis)	Reptilia	FZD2⁶	--	90(a)	1 ↔ 1	6(63838547-63840229)
African clawed frog (Xenopus laevis)	Amphibia	Xl.560²	Xenopus laevis frizzled-2 (xfz2) mRNA, complete cds	79.29(n)		AF139165.1
zebrafish (Danio rerio)	Actinopterygii	fzd2¹	frizzled homolog 2	73.58(n) 80.56(a)		30370 NM_131140.1 NP_571215.1
fruit fly (Drosophila melanogaster)	Insecta	fz³	determination of sensory organ precursor cell more	48(a)		--
worm (Caenorhabditis elegans)	Secernentea	mom-5³	Drosophila tissue polarity protein like	38(a) (best of 2)		I(9973695-9977388) --

ENSEMBL Gene Tree for FZD2 (if available)
TreeFam Gene Tree for FZD2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FZD2 gene

FZD10² FZD3² FZD8² FZD1² FZD5² FZD9² SFRP4² SMO²

FZD4² FZD6² SFRP1² FRZB² FZD7² SFRP5² SFRP2²

10 SIMAP similar genes for FZD2 using alignment to 2 protein entries: FZD2_HUMAN (see all proteins):

FZD1 FZD7 GPCR FZD5 FZD6 FZD10

FZD3 FZD9 FZD8 FZD4

FZD2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs117908009^1,2	F,	--	42632812(+)	`CTCAAG/AATGCT`	1	--	us2k¹		1		EA	120
rs139129324^1,2		--	42632824(+)	`TGAGAC/TGGACT`	1	--	us2k¹		0	--	--	--	--
rs16970804^1,2	C,F,H,	--	42632847(+)	`TGAGGA/TTCAAA`	1	--	us2k¹		18		NA EA NS WA	1414
rs189472601^1,2		--	42632946(+)	`TGGGTA/GGGCTG`	1	--	us2k¹		0	--	--	--	--
rs192680549^1,2		--	42633026(+)	`TTTCAC/TCCTGG`	1	--	us2k¹		0	--	--	--	--
rs184493197^1,2		--	42633040(+)	`AGGGAA/GAAGGC`	1	--	us2k¹		0	--	--	--	--
rs189205863^1,2		--	42633053(+)	`ATTCCC/TCAGGA`	1	--	us2k¹		0	--	--	--	--
rs111828984^1,2		--	42633059(+)	`CAGGAG/TGTAAT`	1	--	us2k¹		1		CSA	2
rs181217476^1,2		--	42633092(+)	`GAAACC/TGGAAC`	1	--	us2k¹		0	--	--	--	--
rs58384481^1,2	C,	--	42633133(+)	`AAAAA-/TTTTTT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FZD2 (42634925 - 42636907 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FZD2
1 CNV: 88485

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FZD2 for disorders           About GeneDecksing

OMIM gene information: 600667    OMIM disorders: --

10 diseases for FZD2:    About MalaCards

basal cell carcinoma bipolar disorder esophageal carcinoma esophagitis

carcinoma melanoma prostatitis neuronitis

colorectal cancer glioblastoma

Human Genome Epidemiology (HuGE) Navigator: FZD2 (2 documents)

Export disorders for FZD2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FZD2 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with FZD2)

Utopia: connect your pdf to the dynamic
world of online information

A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1. (PubMed id 7558010)^{1, 2, 3, 9} Zhao Z.... Caskey C.T. (1995)
Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7. (PubMed id 9813155)^{1, 2, 3, 9} Sagara N.... Katoh M. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. (PubMed id 9707618)^{1, 2} Tanaka S.... Sugimachi K. (1998)
An anti-Wnt5a antibody suppresses metastasis of gastri c cancer cells in vivo by inhibiting receptor-mediated endocytosis. (PubMed id 22101459)¹ Hanaki H....Kikuchi A. (2012)
Expression profile of frizzled receptors in human medu lloblastomas. (PubMed id 21850537)¹ Salsano E....Finocchiaro G. (2012)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)¹ Jugessur A....Murray J.C. (2010)
Wnt5a regulates distinct signalling pathways by bindi ng to Frizzled2. (PubMed id 19910923)¹ Sato A....Kikuchi A. (2010)
cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzl ed-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells. (PubMed id 19946729)¹ Bazhin A.V....EichmA1ller S.B. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2535	HGNC: 4040	AceView: FZD2	Ensembl:ENSG00000180340	euGenes: HUgn2535
ECgene: FZD2	Kegg: 2535	H-InvDB: FZD2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FZD2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FZD2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FZD2 gene:
Search GeneIP for patents involving FZD2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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frizzled family receptor 2

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