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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FZD2 Gene

protein-coding   GIFtS: 63
GCID: GC17P042645

frizzled family receptor 2

(Previous names: frizzled (Drosophila) homolog 2, frizzled homolog 2 (Drosophila),...)
 Explore 10 diseases affiliated with
FZD2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FZD2    

Aliases
for FZD2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Frizzled Family Receptor 21 2     Frizzled Homolog 22
Frizzled 2, Seven Transmembrane Spanning Receptor1 2     Frizzled-21
HFz21     Fz-23
Frizzled (Drosophila) Homolog 21     FzE23
Frizzled Homolog 2 (Drosophila)1     Fz-23
Fz22     FzE23

External Ids:    HGNC: 40401   Entrez Gene: 25352   Ensembl: ENSG000001803407   OMIM: 6006675   UniProtKB: Q143323   

Export aliases for FZD2 gene to outside databases

Previous GC identifers: GC17P042290 GC17P044812 GC17P043109 GC17P043110 GC17P039990 GC17P038404


Summaries
for FZD2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FZD2:
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain
proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene
encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the
wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene
products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways.
(provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: FZD2_HUMAN, Q14332
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling
pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of
beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been
seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated
in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways
seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of
polarity information during tissue morphogenesis and/or in differentiated tissues

Gene Wiki entry for FZD2


Genomic Views
for FZD2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FZD2 gene promoter:
         CUTL1   AP-2gamma   c-Ets-1   POU2F1   FOXO4   COMP1   POU2F1a   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FZD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FZD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FZD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.1   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.1

FZD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZD2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P042645:  view genomic region     (about GC identifiers)

Start:
 42,634,925 bp from pter      End:
 42,636,907 bp from pter
Size:
 1,983 bases      Orientation:
 plus strand

Proteins
for FZD2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FZD2_HUMAN, Q14332 (See protein sequence)
Recommended Name: Frizzled-2 precursor  
Size: 565 amino acids; 63554 Da
Subcellular location: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: Q0VG82

Explore the universe of human proteins at neXtProt for FZD2: NX_Q14332

Post-translational modifications:

  • Ubiquitinated by ZNRF3, leading to its degradation by the proteasome (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14332

    • FZD2 Protein expression data from MOPED and PaxDb:    About this image 
    FZD2 Protein Expression
    REFSEQ proteins: NP_001457.1  
    ENSEMBL proteins: 
     ENSP00000323901  
    Reactome Protein details: Q14332
    Human Recombinant Protein Products for FZD2: 
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    Uscn Proteins for FZD2

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA19038973
    GO:0005886plasma membrane IDA18929644
    GO:0016021integral to membrane IEA--
    GO:0032589neuron projection membrane IBA--
    GO:0045177apical part of cell IBA--

    FZD2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for FZD2

    Protein Domains /
    Families
    for FZD2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FZD2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000539 Frizzled
     IPR020067 Frizzled_dom
     IPR015526 Frizzled/SFRP
     IPR017981 GPCR_2-like
     IPR026550 FZD2

    Graphical View of Domain Structure for InterPro Entry Q14332

    ProtoNet protein and cluster: Q14332

    1 Blocks protein family: IPB000539 Frizzled protein signature

    UniProtKB/Swiss-Prot: FZD2_HUMAN, Q14332
    Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the
    activation of the Wnt/beta-catenin signaling pathway (By similarity)
    Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
    Similarity: Belongs to the G-protein coupled receptor Fz/Smo family
    Similarity: Contains 1 FZ (frizzled) domain


    Function
    for FZD2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FZD2_HUMAN, Q14332
    Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling
    pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of
    beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been
    seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated
    in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways
    seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of
    polarity information during tissue morphogenesis and/or in differentiated tissues

         Genatlas biochemistry entry for FZD2:
    Drosophila frizzled polarity gene homolog,G protein coupled receptor superfamily,exhibiting characteristics of a WNT
    receptor,expressed in adult heart,fetal brain,lung and kidney,involved in signal transduction,activating Dishevelled

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005515protein binding ----
    GO:0017147Wnt-protein binding IBA--
    GO:0030165PDZ domain binding IPI19388021
    GO:0042813Wnt-activated receptor activity IBA--
         
    FZD2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for FZD2:
     Decreased BPV1 E2 protein expr  Decreased G3BP1 protein expres  Increased HPV18 LCR reporter a  Synthetic lethal with imatinib 

         11 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fzd2):
     cardiovascular system  craniofacial  digestive/alimentary  embryogenesis  growth/size 
     hearing/vestibular/ear  homeostasis/metabolism  mortality/aging  nervous system  skeleton 
     taste/olfaction 

    FZD2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FZD2 

    miRNA
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    hsa-miR-3689b hsa-miR-30c hsa-miR-1226 hsa-miR-4328 hsa-miR-520d-5p hsa-miR-522 hsa-miR-30d hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmid: FZD2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FZD2 (see all 7)
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    Gene Editing
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    Clone
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD2


    Pathways & Interactions
    for FZD2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt Signaling Pathway
    		Wnt Signaling Pathway1.00
    		Wnt signaling pathway0.30
    		Wnt Signaling Pathway and Pluripotency0.55
    		Wnt Signaling Pathway NetPath0.22
    		Wnt Signaling Pathway0.33
    2Translation_Non-genomic (rapid) action of Androgen Receptor
    		Translation_Non-genomic (rapid) action of Androgen Receptor1.00
    		Translation Non-genomic (rapid) action of Androgen Receptor0.99
    3Transcription_Androgen Receptor nuclear signaling
    		Transcription_Androgen Receptor nuclear signaling1.00
    		Transcription Androgen Receptor nuclear signaling0.99
    4Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		GSK3 Signaling0.61
    5Human Embryonic Stem Cell Pluripotency
    		Human Embryonic Stem Cell Pluripotency1.00
    		Factors Promoting Cardiogenesis in Vertebrates0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for FZD2
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 R&D Systems Pathway for FZD2
        Wnt Signaling Pathway

    5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FZD2 (see all 11)
        Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Colorectal Cancer Metastasis
    Glioblastoma Multiforme

    2 GeneGo (Thomson Reuters) Pathways for FZD2
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    5/6 BioSystems Pathways for FZD2 (see all 6) 
        MicroRNAs in cardiomyocyte hypertrophy
    Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway
    Wnt Signaling Pathway NetPath
    Noncanonical Wnt signaling pathway

    4        Reactome Pathways for FZD2
        Signal Transduction
    Signaling by GPCR
    GPCR ligand binding
    Class B/2 (Secretin family receptors)


    4         Kegg Pathways  (Kegg details for FZD2):
        Wnt signaling pathway
    Melanogenesis
    Pathways in cancer
    Basal cell carcinoma


    FZD2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FZD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/42 Interacting proteins for FZD2 (Q143323 ENSP000003239014) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG4P783523, ENSP000002938134I2D: score=3 STRING: ENSP00000293813
    ROR2Q019743, ENSP000003648604I2D: score=3 STRING: ENSP00000364860
    ARRB2ENSP000002692604STRING: ENSP00000269260
    DVL2ENSP000000053404STRING: ENSP00000005340
    LRP6ENSP000002613494STRING: ENSP00000261349
    About this table

    Gene Ontology (GO): 5/30 biological process terms (GO ID links to tree view) (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001775cell activation ----
    GO:0001944vasculature development IBA--
    GO:0003149membranous septum morphogenesis IEA--
    GO:0003150muscular septum morphogenesis IEA--
    GO:0003151outflow tract morphogenesis IEA--

    FZD2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FZD2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FZD2

    1 HMDB Compound for FZD2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about FZD2 

    Transcripts
    for FZD2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FZD2 gene: 
    NM_001466.3  

    Unigene Cluster for FZD2:

    Frizzled family receptor 2
    Hs.142912  [show with all ESTs]
    Unigene Representative Sequence: NM_001466
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000315323(uc002igx.2)

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    hsa-miR-3689b hsa-miR-30c hsa-miR-1226 hsa-miR-4328 hsa-miR-520d-5p hsa-miR-522 hsa-miR-30d hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmid: FZD2 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB017364.1 BC052266.1 BC113402.1 BC113404.1 L37882.1 

    3 DOTS entries:

    DT.208046  DT.102824356  DT.95263888 

    24/69 AceView cDNA sequences (see all 69):

    BF512595 BC052266 CF130992 L37882 AA297335 BE392146 BM666204 BC036881 
    CN484180 AB017364 BQ231687 CA429523 NM_001466 AI860140 AW245391 BU681711 
    AI858773 BG054704 BX106729 CA390932 AW474898 AI279304 BQ650917 BM927842 

    GeneLoc Exon Structure


    Expression
    for FZD2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FZD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACGCTCATCG
    FZD2 Expression
    About this image

    FZD2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartOutflow TractNeural Crest Outflow Tract CellsNeural Crest
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest

    See FZD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FZD2

    SOURCE GeneReport for Unigene cluster: Hs.142912

    UniProtKB/Swiss-Prot: FZD2_HUMAN, Q14332
    Tissue specificity: Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung, kidney,
    pancreas, prostate, testis, ovary and colon. In the fetus, expressed in brain, lung and kidney. Low levels in fetal
    liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including FZD2: 
              G Protein Coupled Receptors 384HT in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD2

    Orthologs
    for FZD2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FZD2 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FZD21 frizzled family receptor 2 88.1(n)
    90.58(a)    		   374061  NM_204222.1  NP_989553.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FZD26
    		 --
    		 90(a)
    		 1 ↔ 1
    		 6(63838547-63840229)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.5602 Xenopus laevis frizzled-2 (xfz2) mRNA, complete cds 79.29(n)    AF139165.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii fzd21 frizzled homolog 2 73.58(n)
    80.56(a)    		   30370  NM_131140.1  NP_571215.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta fz3 determination of sensory organ precursor
    cell more    		 48(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea mom-53 Drosophila tissue polarity protein like 38(a)
    (best of 2)    		   I(9973695-9977388)   --


    ENSEMBL Gene Tree for FZD2 (if available)
    TreeFam Gene Tree for FZD2 (if available) 

    Paralogs
    for FZD2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FZD2 gene
    FZD102  FZD32  FZD82  FZD12  FZD52  FZD92  SFRP42  SMO2  
    FZD42  FZD62  SFRP12  FRZB2  FZD72  SFRP52  SFRP22  
    10 SIMAP similar genes for FZD2 using alignment to 2 protein entries:     FZD2_HUMAN (see all proteins):
    FZD1    FZD7    GPCR    FZD5    FZD6    FZD10
    FZD3    FZD9    FZD8    FZD4

    FZD2 for paralogs           About GeneDecksing



    Genomic Variants
    for FZD2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/99 NCBI SNPs in FZD2 are shown (see all 99)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1179080091,2
    		F--42632812(+) CTCAAG/AATGCT 1 -- us2k11Minor allele frequency- A:0.04EA 120
    rs1391293241,2
    		--42632824(+) TGAGAC/TGGACT 1 -- us2k10--------
    rs169708041,2
    		C,F,H--42632847(+) TGAGGA/TTCAAA 1 -- us2k118Minor allele frequency- T:0.32NA EA NS WA 1414
    rs1894726011,2
    		--42632946(+) TGGGTA/GGGCTG 1 -- us2k10--------
    rs1926805491,2
    		--42633026(+) TTTCAC/TCCTGG 1 -- us2k10--------
    rs1844931971,2
    		--42633040(+) AGGGAA/GAAGGC 1 -- us2k10--------
    rs1892058631,2
    		--42633053(+) ATTCCC/TCAGGA 1 -- us2k10--------
    rs1118289841,2
    		--42633059(+) CAGGAG/TGTAAT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1812174761,2
    		--42633092(+) GAAACC/TGGAAC 1 -- us2k10--------
    rs583844811,2
    		C--42633133(+) AAAAA-/TTTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FZD2 (42634925 - 42636907 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for FZD2
         1 CNV: 88485

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    Disorders / Diseases
    for FZD2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FZD2 for disorders           About GeneDecksing

    OMIM gene information: 600667    OMIM disorders: --

    10 diseases for FZD2:    About MalaCards
    basal cell carcinoma    bipolar disorder    esophageal carcinoma    esophagitis
    carcinoma    melanoma    prostatitis    neuronitis
    colorectal cancer    glioblastoma

    Human Genome Epidemiology (HuGE) Navigator: FZD2 (2 documents)

    Export disorders for FZD2 gene to outside databases

    Publications
    for FZD2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FZD2 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with FZD2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1. (PubMed id 7558010)1, 2, 3, 9 Zhao Z.... Caskey C.T. (1995)
    2. Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7. (PubMed id 9813155)1, 2, 3, 9 Sagara N.... Katoh M. (1998)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. (PubMed id 9707618)1, 2 Tanaka S.... Sugimachi K. (1998)
    5. An anti-Wnt5a antibody suppresses metastasis of gastri c cancer cells in vivo by inhibiting receptor-mediated endocytosis. (PubMed id 22101459)1 Hanaki H....Kikuchi A. (2012)
    6. Expression profile of frizzled receptors in human medu lloblastomas. (PubMed id 21850537)1 Salsano E....Finocchiaro G. (2012)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1 Jugessur A....Murray J.C. (2010)
    9. Wnt5a regulates distinct signalling pathways by bindi ng to Frizzled2. (PubMed id 19910923)1 Sato A....Kikuchi A. (2010)
    10. cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzl ed-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells. (PubMed id 19946729)1 Bazhin A.V....EichmA1ller S.B. (2010)

    External Searches for FZD2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FZD2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2535 HGNC: 4040 AceView: FZD2 Ensembl:ENSG00000180340 euGenes: HUgn2535
    ECgene: FZD2 Kegg: 2535 H-InvDB: FZD2

    Other Databases showing FZD2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FZD2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FZD2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FZD2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FZD2 gene:
    Search GeneIP for patents involving FZD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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