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FZD2 Gene

protein-coding   GIFtS: 65
GCID: GC17P042645

Frizzled Class Receptor 2

(Previous names: frizzled (Drosophila) homolog 2, frizzled homolog 2 (Drosophila),...)
  Search for FZD2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Frizzled Class Receptor 21 2     Frizzled Homolog 22
Frizzled 2, Seven Transmembrane Spanning Receptor1 2     frizzled-22
Frizzled Family Receptor 21 2     fz-22
hFz22 3     fzE22
Frizzled (Drosophila) Homolog 21     Fz-23
Frizzled Homolog 2 (Drosophila)1     FzE23
Fz22     

External Ids:    HGNC: 40401   Entrez Gene: 25352   Ensembl: ENSG000001803407   OMIM: 6006675   UniProtKB: Q143323   

Export aliases for FZD2 gene to outside databases

Previous GC identifers: GC17P042290 GC17P044812 GC17P043109 GC17P043110 GC17P039990 GC17P038404


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FZD2 Gene:
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane
domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This
gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the
wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A
gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent
pathways. (provided by RefSeq, Dec 2010)

GeneCards Summary for FZD2 Gene:
FZD2 (frizzled class receptor 2) is a protein-coding gene. GO annotations related to this gene include Wnt-protein binding and G-protein coupled receptor activity. An important paralog of this gene is FZD3.

UniProtKB/Swiss-Prot: FZD2_HUMAN, Q14332
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical
signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear
accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and
calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway
or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of
GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and
intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues

Gene Wiki entry for FZD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the FZD2 gene promoter:
         CUTL1   AP-2gamma   c-Ets-1   POU2F1   FOXO4   COMP1   POU2F1a   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFZD2 promoter sequence
   Search Chromatin IP Primers for FZD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FZD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.1   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.1

FZD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZD2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P042645:  view genomic region     (about GC identifiers)

Start:
42,634,812 bp from pter      End:
42,638,630 bp from pter
Size:
3,819 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FZD2_HUMAN, Q14332 (See protein sequence)
Recommended Name: Frizzled-2 precursor  
Size: 565 amino acids; 63554 Da
Secondary accessions: Q0VG82

Explore the universe of human proteins at neXtProt for FZD2: NX_Q14332

Explore proteomics data for FZD2 at MOPED

Post-translational modifications: 

  • Ubiquitinated by ZNRF3, leading to its degradation by the proteasome (By similarity)1
  • Ubiquitination2 at Lys214
  • Glycosylation2 at Ser32, Asn53, Asn154, Thr165, Thr166, Thr179, Thr194
  • Modification sites at PhosphoSitePlus

  • See FZD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001457.1  
    ENSEMBL proteins: 
     ENSP00000323901  
    Reactome Protein details: Q14332

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FZD: GPCR / Class F : Frizzled receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: FZD2
    Frizzled Class GPCRs

    5 InterPro protein domains:
     IPR000539 Frizzled
     IPR020067 Frizzled_dom
     IPR015526 Frizzled/SFRP
     IPR017981 GPCR_2-like
     IPR026550 FZD2

    Graphical View of Domain Structure for InterPro Entry Q14332

    ProtoNet protein and cluster: Q14332

    1 Blocks protein domain: IPB000539 Frizzled protein signature

    UniProtKB/Swiss-Prot: FZD2_HUMAN, Q14332
    Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in
    the activation of the Wnt/beta-catenin signaling pathway (By similarity)
    Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
    Similarity: Belongs to the G-protein coupled receptor Fz/Smo family
    Similarity: Contains 1 FZ (frizzled) domain


    Find genes that share domains with FZD2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FZD2_HUMAN, Q14332
    Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical
    signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear
    accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and
    calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway
    or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of
    GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and
    intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues

         Genatlas biochemistry entry for FZD2:
    Drosophila frizzled polarity gene homolog,G protein coupled receptor superfamily,exhibiting characteristics of a
    WNT receptor,expressed in adult heart,fetal brain,lung and kidney,involved in signal transduction,activating
    Dishevelled

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005515protein binding ----
    GO:0017147Wnt-protein binding IBA--
    GO:0030165PDZ domain binding IPI19388021
         
    Find genes that share ontologies with FZD2           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for FZD2:
     Decreased BPV1 E2 protein expr  Decreased G3BP1 protein expres  Increased HPV18 LCR reporter a  Synthetic lethal with imatinib 

         11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fzd2):
     cardiovascular system  craniofacial  digestive/alimentary  embryogenesis  growth/size/body 
     hearing/vestibular/ear  homeostasis/metabolism  mortality/aging  nervous system  skeleton 
     taste/olfaction 

    Find genes that share phenotypes with FZD2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FZD2
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    miRNA
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    hsa-miR-3689b hsa-miR-30c hsa-miR-1226 hsa-miR-4328 hsa-miR-520d-5p hsa-miR-522 hsa-miR-30d hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidFZD2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: FZD2 (NM_001466)
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FZD2_HUMAN, Q14332: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA19038973
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0030669clathrin-coated endocytic vesicle membrane TAS--

    Find genes that share ontologies with FZD2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FZD2 About   (see all 26)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    2beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Ca2+ pathway0.43
    Signaling by Wnt0.79
    3CDK-mediated phosphorylation and removal of Cdc6
    Asymmetric localization of PCP proteins0.75
    WNT5A-dependent internalization of FZD2, FZD5 and ROR20.00
    PCP/CE pathway0.70
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    GSK3 Signaling0.61


    Find genes that share SuperPaths with FZD2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for FZD2
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FZD2 (see all 11)
        Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Colorectal Cancer Metastasis
    Glioblastoma Multiforme

    2 GeneGo (Thomson Reuters) Pathways for FZD2
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    Selected BioSystems Pathways for FZD2 (see all 6)
        MicroRNAs in cardiomyocyte hypertrophy
    Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway NetPath
    Wnt signaling network

    2 Sino Biological Pathways for FZD2
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    5 Reactome Pathways for FZD2
        disassembly of the destruction complex and recruitment of AXIN to the membrane
    Ca2+ pathway
    WNT5A-dependent internalization of FZD2, FZD5 and ROR2
    TCF dependent signaling in response to WNT
    Class B/2 (Secretin family receptors)


    Selected Kegg Pathways  (Kegg details for FZD2) (see all 7):
        Wnt signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection
    Pathways in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FZD2: 
              G Protein Coupled Receptors 384HT in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FZD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FZD2 (Q143323 ENSP000003239014) via UniProtKB, MINT, STRING, and/or I2D (see all 89)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ROR2Q019743, ENSP000003648604I2D: score=3 STRING: ENSP00000364860
    DLG4P783523I2D: score=3 
    ARRB2ENSP000002692604STRING: ENSP00000269260
    MAPK9ENSP000003214104STRING: ENSP00000321410
    RAC1ENSP000003484614STRING: ENSP00000348461
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001944vasculature development IBA--
    GO:0003149membranous septum morphogenesis IEA--
    GO:0003150muscular septum morphogenesis IEA--
    GO:0003151outflow tract morphogenesis IEA--
    GO:0007166cell surface receptor signaling pathway ----

    Find genes that share ontologies with FZD2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for FZD2

    1 HMDB Compound for FZD2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FZD2 gene: 
    NM_001466.3  

    Unigene Cluster for FZD2:

    Frizzled family receptor 2
    Hs.142912  [show with all ESTs]
    Unigene Representative Sequence: NM_001466
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000315323(uc002igx.2)
    miRNA
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    hsa-miR-3689b hsa-miR-30c hsa-miR-1226 hsa-miR-4328 hsa-miR-520d-5p hsa-miR-522 hsa-miR-30d hsa-miR-410
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    Additional mRNA sequence: 

    AB017364.1 BC052266.1 BC113402.1 BC113404.1 L37882.1 

    3 DOTS entries:

    DT.208046  DT.102824356  DT.95263888 

    Selected AceView cDNA sequences (see all 69):

    BC052266 CN484180 BQ231687 CA429523 BE392146 L37882 BC036881 CF130992 
    NM_001466 BF512595 BM666204 AA297335 AB017364 AI125998 BF512236 CA432236 
    AI860140 BE550029 AI858773 BG054704 BF224122 AW474898 AI802021 BX106267 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FZD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGCTCATCG
    FZD2 Expression
    About this image


    FZD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Midbrain tegmentum
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 4D20.8, NCr-fac Progenitor
     
     Epidermis (Integumentary System)
             human epithelial stem cells
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical Arteries
    FZD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FZD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.142912

    UniProtKB/Swiss-Prot: FZD2_HUMAN, Q14332
    Tissue specificity: Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung,
    kidney, pancreas, prostate, testis, ovary and colon. In the fetus, expressed in brain, lung and kidney. Low
    levels in fetal liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FZD2: 
              G Protein Coupled Receptors 384HT in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat
              Notch Signaling Pathway in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for FZD2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fzd21 , 5 frizzled homolog 2 (Drosophila)1, 5 92.18(n)1
    99.64(a)1
      11 (66.45 cM)5
    572651  NM_020510.21  NP_065256.11 
     1026043965 
    chicken
    (Gallus gallus)
    Aves FZD21 frizzled family receptor 2 88.58(n)
    91.53(a)
      374061  NM_204222.1  NP_989553.1 
    lizard
    (Anolis carolinensis)
    Reptilia FZD26
    frizzled family receptor 2
    89(a)
    1 ↔ 1
    6(63838547-63840229)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.5602 Xenopus laevis frizzled-2 (xfz2) mRNA, complete cds 79.29(n)    AF139165.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fzd21 frizzled homolog 2 74.03(n)
    80.76(a)
      30370  NM_131140.1  NP_571215.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fz3 determination of sensory organ
    precursor cell more
    48(a)     --


    ENSEMBL Gene Tree for FZD2 (if available)
    TreeFam Gene Tree for FZD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FZD2 gene
    FZD32  FZD102  FZD82  FZD12  FZD52  FZD92  SFRP42  SMO2  
    FZD42  FZD62  SFRP12  FRZB2  FZD72  SFRP52  SFRP22  
    10 SIMAP similar genes for FZD2 using alignment to 2 protein entries:     FZD2_HUMAN (see all proteins):
    FZD1    FZD7    GPCR    FZD5    FZD6    FZD10
    FZD3    FZD9    FZD8    FZD4

    Find genes that share paralogs with FZD2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FZD2 (see all 122)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1179080091,2
    F--42632812(+) CTCAAG/AATGCT 1 -- us2k11Minor allele frequency- A:0.04EA 120
    rs1391293241,2
    --42632824(+) TGAGAC/TGGACT 1 -- us2k10--------
    rs169708041,2
    C,F,H--42632847(+) TGAGGA/TTCAAA 1 -- us2k118Minor allele frequency- T:0.32NA EA NS WA 1414
    rs1894726011,2
    --42632946(+) TGGGTA/GGGCTG 1 -- us2k10--------
    rs1926805491,2
    --42633026(+) TTTCAC/TCCTGG 1 -- us2k10--------
    rs1844931971,2
    --42633040(+) AGGGAA/GAAGGC 1 -- us2k10--------
    rs1892058631,2
    --42633053(+) ATTCCC/TCAGGA 1 -- us2k10--------
    rs1118289841,2
    F--42633059(+) CAGGAG/TGTAAT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1812174761,2
    --42633092(+) GAAACC/TGGAAC 1 -- us2k10--------
    rs583844811,2
    C--42633133(+) AAAAA-/AT/T  
            
    TTTTT
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FZD2 (42634812 - 42638630 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FZD2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FZD2
    DNA2.0 Custom Variant and Variant Library Synthesis for FZD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600667    OMIM disorders: --


    Find genes that share disorders with FZD2           About GenesLikeMe

    Genetic Association Database (GAD): FZD2
    Human Genome Epidemiology (HuGE) Navigator: FZD2 (2 documents)

    Export disorders for FZD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FZD2 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with FZD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1. (PubMed id 7558010)1, 2, 3, 9 Zhao Z.... Caskey C.T. (Genomics 1995)
    2. Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7. (PubMed id 9813155)1, 2, 3, 9 Sagara N.... Katoh M. (Biochem. Biophys. Res. Commun. 1998)
    3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    4. Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort. (PubMed id 19308021)1, 4 Ollila H.M....Paunio T. (Mol. Psychiatry 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. (PubMed id 9707618)1, 2 Tanaka S.... Sugimachi K. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    7. An anti-Wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis. (PubMed id 22101459)1 Hanaki H....Kikuchi A. (Mol. Cancer Ther. 2012)
    8. Expression profile of frizzled receptors in human medulloblastomas. (PubMed id 21850537)1 Salsano E....Finocchiaro G. (J. Neurooncol. 2012)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2535 HGNC: 4040 AceView: FZD2 Ensembl:ENSG00000180340 euGenes: HUgn2535
    ECgene: FZD2 Kegg: 2535 H-InvDB: FZD2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FZD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FZD2 gene:
    Search GeneIP for patents involving FZD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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