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Aliases for FZD2 Gene

Aliases for FZD2 Gene

  • Frizzled Class Receptor 2 2 3
  • Frizzled 2, Seven Transmembrane Spanning Receptor 2 3
  • Frizzled Family Receptor 2 2 3
  • Fz-2 3 4
  • FzE2 3 4
  • HFz2 3 4
  • Frizzled (Drosophila) Homolog 2 2
  • Frizzled Homolog 2 (Drosophila) 2
  • Frizzled Homolog 2 3
  • Frizzled-2 3
  • Fz2 3

External Ids for FZD2 Gene

Summaries for FZD2 Gene

Entrez Gene Summary for FZD2 Gene

  • This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. [provided by RefSeq, Dec 2010]

GeneCards Summary for FZD2 Gene

FZD2 (Frizzled Class Receptor 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include G-protein coupled receptor activity and Wnt-protein binding. An important paralog of this gene is FZD10.

UniProtKB/Swiss-Prot for FZD2 Gene

  • Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues

Gene Wiki entry for FZD2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FZD2 Gene

Genomics for FZD2 Gene

Genomic Location for FZD2 Gene

Start:
44,557,444 bp from pter
End:
44,561,262 bp from pter
Size:
3,819 bases
Orientation:
Plus strand

Genomic View for FZD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FZD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FZD2 Gene

Regulatory Elements for FZD2 Gene

Proteins for FZD2 Gene

  • Protein details for FZD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14332-FZD2_HUMAN
    Recommended name:
    Frizzled-2
    Protein Accession:
    Q14332
    Secondary Accessions:
    • Q0VG82

    Protein attributes for FZD2 Gene

    Size:
    565 amino acids
    Molecular mass:
    63554 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FZD2 Gene

Proteomics data for FZD2 Gene at MOPED

Post-translational modifications for FZD2 Gene

  • Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys214
  • Glycosylation at Ser32, Asn53, Asn154, Thr165, Thr166, Thr179, and Thr194

Other Protein References for FZD2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FZD2 Gene

Domains for FZD2 Gene

Gene Families for FZD2 Gene

HGNC:
  • FZD :GPCR / Class F : Frizzled receptors
IUPHAR :

Protein Domains for FZD2 Gene

UniProtKB/Swiss-Prot:

FZD2_HUMAN
Domain:
  • Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.:
    • Q14332
  • The FZ domain is involved in binding with Wnt ligands.:
    • Q14332
  • Contains 1 FZ (frizzled) domain.:
    • Q14332
Family:
  • Belongs to the G-protein coupled receptor Fz/Smo family.:
    • Q14332
genes like me logo Genes that share domains with FZD2: view

Function for FZD2 Gene

Molecular function for FZD2 Gene

GENATLAS Biochemistry: Drosophila frizzled polarity gene homolog,G protein coupled receptor superfamily,exhibiting characteristics of a WNT receptor,expressed in adult heart,fetal brain,lung and kidney,involved in signal transduction,activating Dishevelled
UniProtKB/Swiss-Prot Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues

Gene Ontology (GO) - Molecular Function for FZD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity IBA --
GO:0005515 protein binding --
GO:0017147 Wnt-protein binding IBA --
GO:0030165 PDZ domain binding IPI 19388021
genes like me logo Genes that share ontologies with FZD2: view
genes like me logo Genes that share phenotypes with FZD2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FZD2 Gene

Localization for FZD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FZD2 Gene

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FZD2 Gene COMPARTMENTS Subcellular localization image for FZD2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for FZD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19038973
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with FZD2: view

Pathways for FZD2 Gene

genes like me logo Genes that share pathways with FZD2: view

Gene Ontology (GO) - Biological Process for FZD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001944 vasculature development --
GO:0003149 membranous septum morphogenesis IEA --
GO:0003150 muscular septum morphogenesis IEA --
GO:0003151 outflow tract morphogenesis IEA --
GO:0007166 cell surface receptor signaling pathway --
genes like me logo Genes that share ontologies with FZD2: view

Compounds for FZD2 Gene

(1) HMDB Compounds for FZD2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with FZD2: view

Transcripts for FZD2 Gene

mRNA/cDNA for FZD2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(69) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FZD2 Gene

Frizzled family receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FZD2 Gene

No ASD Table

Relevant External Links for FZD2 Gene

GeneLoc Exon Structure for
FZD2
ECgene alternative splicing isoforms for
FZD2

Expression for FZD2 Gene

mRNA expression in normal human tissues for FZD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FZD2 Gene

This gene is overexpressed in Artery - Aorta (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FZD2 Gene

SOURCE GeneReport for Unigene cluster for FZD2 Gene Hs.142912

mRNA Expression by UniProt/SwissProt for FZD2 Gene

Q14332-FZD2_HUMAN
Tissue specificity: Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary and colon. In the fetus, expressed in brain, lung and kidney. Low levels in fetal liver
genes like me logo Genes that share expressions with FZD2: view

Orthologs for FZD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FZD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FZD2 36
  • 99.02 (n)
  • 99.27 (a)
FZD2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FZD2 36
  • 94.1 (n)
  • 99.82 (a)
FZD2 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FZD2 36
  • 95.04 (n)
  • 99.65 (a)
FZD2 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fzd2 36
  • 92.18 (n)
  • 99.64 (a)
Fzd2 16
Fzd2 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FZD2 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FZD2 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fzd2 36
  • 91.82 (n)
  • 97.79 (a)
chicken
(Gallus gallus)
Aves FZD2 36
  • 88.58 (n)
  • 91.53 (a)
FZD2 37
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FZD2 37
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.560 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fzd2 36
  • 77.46 (n)
  • 92.76 (a)
Str.2004 36
zebrafish
(Danio rerio)
Actinopterygii fzd2 36
  • 74.03 (n)
  • 80.76 (a)
fzd2 37
  • 78 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta fz 37
  • 44 (a)
OneToMany
fz 38
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea mom-5 38
  • 38 (a)
cfz-2 38
  • 36 (a)
Species with no ortholog for FZD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FZD2 Gene

ENSEMBL:
Gene Tree for FZD2 (if available)
TreeFam:
Gene Tree for FZD2 (if available)

Paralogs for FZD2 Gene

Paralogs for FZD2 Gene

Selected SIMAP similar genes for FZD2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FZD2: view

Variants for FZD2 Gene

Sequence variations from dbSNP and Humsavar for FZD2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1047995 -- 44,561,157(+) AGTTT(G/T)AATAC utr-variant-3-prime
rs3803869 -- 44,559,686(+) AGTTG(G/T)GGGGA utr-variant-3-prime
rs4792948 -- 44,560,120(+) TCTTT(C/T)TCCTG utr-variant-3-prime
rs4793121 -- 44,560,541(+) TAAAA(C/T)TTGTC utr-variant-3-prime
rs7216125 -- 44,556,909(+) TCGAT(A/T)TGAAA upstream-variant-2KB

Relevant External Links for FZD2 Gene

HapMap Linkage Disequilibrium report
FZD2

No data available for Structural Variations from Database of Genomic Variants (DGV) for FZD2 Gene

Disorders for FZD2 Gene

Relevant External Links for FZD2

Genetic Association Database (GAD)
FZD2
Human Genome Epidemiology (HuGE) Navigator
FZD2
genes like me logo Genes that share disorders with FZD2: view

No data available for UniProtKB/Swiss-Prot for FZD2 Gene

Publications for FZD2 Gene

  1. A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1. (PMID: 7558010) Zhao Z. … Caskey C.T. (Genomics 1995) 2 3 4 23
  2. Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7. (PMID: 9813155) Sagara N. … Katoh M. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23
  3. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. (PMID: 9707618) Tanaka S. … Sugimachi K. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort. (PMID: 19308021) Ollila H.M. … Paunio T. (Mol. Psychiatry 2009) 3 49

Products for FZD2 Gene

Sources for FZD2 Gene

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