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Aliases for FZD10 Gene

Aliases for FZD10 Gene

  • Frizzled Class Receptor 10 2 3 5
  • Frizzled 10, Seven Transmembrane Spanning Receptor 2 3
  • Frizzled Family Receptor 10 2 3
  • FZ-10 3 4
  • HFz10 3 4
  • FzE7 3 4
  • Frizzled (Drosophila) Homolog 10 2
  • Frizzled Homolog 10 (Drosophila) 2
  • Frizzled Homolog 10 3
  • CD350 Antigen 4
  • CD350 3
  • Fz10 3

External Ids for FZD10 Gene

Previous GeneCards Identifiers for FZD10 Gene

  • GC12P129076
  • GC12P130410
  • GC12P129000
  • GC12P129171
  • GC12P130648
  • GC12P127632

Summaries for FZD10 Gene

Entrez Gene Summary for FZD10 Gene

  • This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for FZD10 Gene

FZD10 (Frizzled Class Receptor 10) is a Protein Coding gene. Diseases associated with FZD10 include synovium cancer and colorectal cancer. Among its related pathways are Signaling by GPCR and ERK Signaling. GO annotations related to this gene include G-protein coupled receptor activity and PDZ domain binding. An important paralog of this gene is FZD1.

UniProtKB/Swiss-Prot for FZD10 Gene

  • Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Gene Wiki entry for FZD10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FZD10 Gene

Genomics for FZD10 Gene

Regulatory Elements for FZD10 Gene

Promoters for FZD10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FZD10 on UCSC Golden Path with GeneCards custom track

Genomic Location for FZD10 Gene

Chromosome:
12
Start:
130,162,459 bp from pter
End:
130,165,740 bp from pter
Size:
3,282 bases
Orientation:
Plus strand

Genomic View for FZD10 Gene

Genes around FZD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FZD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FZD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FZD10 Gene

Proteins for FZD10 Gene

  • Protein details for FZD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULW2-FZD10_HUMAN
    Recommended name:
    Frizzled-10
    Protein Accession:
    Q9ULW2

    Protein attributes for FZD10 Gene

    Size:
    581 amino acids
    Molecular mass:
    65336 Da
    Quaternary structure:
    • Interacts with MYOC.

neXtProt entry for FZD10 Gene

Proteomics data for FZD10 Gene at MOPED

Post-translational modifications for FZD10 Gene

  • Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
  • Glycosylation at Asn 48, Asn 153, and Asn 485
  • Modification sites at PhosphoSitePlus

Other Protein References for FZD10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FZD10 Gene

Domains & Families for FZD10 Gene

Protein Domains for FZD10 Gene

Suggested Antigen Peptide Sequences for FZD10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULW2

UniProtKB/Swiss-Prot:

FZD10_HUMAN :
  • Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
  • Belongs to the G-protein coupled receptor Fz/Smo family.
Domain:
  • Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
  • The FZ domain is involved in binding with Wnt ligands.
  • Contains 1 FZ (frizzled) domain.
Family:
  • Belongs to the G-protein coupled receptor Fz/Smo family.
genes like me logo Genes that share domains with FZD10: view

Function for FZD10 Gene

Molecular function for FZD10 Gene

GENATLAS Biochemistry:
Drosophila frizzled polarity gene homolog 10,G protein coupled receptor superfamily,exhibiting characteristics of a WNT receptor,expressed in placenta fetal kidney,fetal lung brain,involved in signal transduction
UniProtKB/Swiss-Prot Function:
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Gene Ontology (GO) - Molecular Function for FZD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 15930302
genes like me logo Genes that share ontologies with FZD10: view
genes like me logo Genes that share phenotypes with FZD10: view

Animal Models for FZD10 Gene

MGI Knock Outs for FZD10:

Animal Model Products

  • Taconic Biosciences Mouse Models for FZD10

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FZD10 Gene

Localization for FZD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FZD10 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FZD10 Gene COMPARTMENTS Subcellular localization image for FZD10 gene
Compartment Confidence
plasma membrane 5
nucleus 3
extracellular 1

Gene Ontology (GO) - Cellular Components for FZD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FZD10: view

Pathways & Interactions for FZD10 Gene

genes like me logo Genes that share pathways with FZD10: view

SIGNOR curated interactions for FZD10 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for FZD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0032956 regulation of actin cytoskeleton organization IMP 19137009
GO:0034260 negative regulation of GTPase activity IMP 19137009
GO:0038031 non-canonical Wnt signaling pathway via JNK cascade IMP 19137009
genes like me logo Genes that share ontologies with FZD10: view

Drugs & Compounds for FZD10 Gene

(1) Drugs for FZD10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with FZD10: view

Transcripts for FZD10 Gene

mRNA/cDNA for FZD10 Gene

Unigene Clusters for FZD10 Gene

Frizzled family receptor 10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FZD10 Gene

No ASD Table

Relevant External Links for FZD10 Gene

GeneLoc Exon Structure for
FZD10
ECgene alternative splicing isoforms for
FZD10

Expression for FZD10 Gene

mRNA expression in normal human tissues for FZD10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FZD10 Gene

This gene is overexpressed in Esophagus - Mucosa (x9.7), Skin - Not Sun Exposed (Suprapubic) (x5.6), Skin - Sun Exposed (Lower leg) (x4.9), and Cervix - Endocervix (x4.1).

Protein differential expression in normal tissues from HIPED for FZD10 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FZD10 Gene



SOURCE GeneReport for Unigene cluster for FZD10 Gene Hs.733275

mRNA Expression by UniProt/SwissProt for FZD10 Gene

Q9ULW2-FZD10_HUMAN
Tissue specificity: Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate.
genes like me logo Genes that share expression patterns with FZD10: view

Protein tissue co-expression partners for FZD10 Gene

Primer Products

In Situ Assay Products

Orthologs for FZD10 Gene

This gene was present in the common ancestor of animals.

Orthologs for FZD10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FZD10 35
  • 91.91 (n)
  • 95.01 (a)
FZD10 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FZD10 35
  • 92.48 (n)
  • 95.01 (a)
FZD10 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fzd10 35
  • 87.09 (n)
  • 92.94 (a)
Fzd10 16
Fzd10 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FZD10 35
  • 99.54 (n)
  • 99.83 (a)
FZD10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fzd10 35
  • 86.98 (n)
  • 92.94 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia FZD10 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves FZD10 35
  • 77.07 (n)
  • 89.01 (a)
FZD10 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FZD10 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fzd10 35
  • 77.41 (n)
  • 85.64 (a)
Str.154 35
African clawed frog
(Xenopus laevis)
Amphibia fzd10b 35
zebrafish
(Danio rerio)
Actinopterygii fzd10 35
  • 71.45 (n)
  • 77.48 (a)
fzd10 36
  • 76 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13569 35
fruit fly
(Drosophila melanogaster)
Insecta fz4 37
  • 28 (a)
fz2 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cfz-2 37
  • 35 (a)
mom-5 37
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToMany
Species with no ortholog for FZD10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FZD10 Gene

ENSEMBL:
Gene Tree for FZD10 (if available)
TreeFam:
Gene Tree for FZD10 (if available)

Paralogs for FZD10 Gene

Paralogs for FZD10 Gene

(10) SIMAP similar genes for FZD10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FZD10: view

Variants for FZD10 Gene

Sequence variations from dbSNP and Humsavar for FZD10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1046890 -- 130,165,225(+) GACTC(C/T)GGCCT utr-variant-3-prime
rs1046893 -- 130,165,471(+) TAGAC(A/C/G)TTTGG utr-variant-3-prime
rs1046895 -- 130,165,496(+) AGGAG(A/C/G)GGGGA utr-variant-3-prime
rs3832815 -- 130,165,306(-) AAAAA(-/A)TGTAT utr-variant-3-prime
rs3741568 -- 130,165,417(-) CTGAA(A/G)GGTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FZD10 Gene

Variant ID Type Subtype PubMed ID
dgv533e1 CNV Complex 17122850
esv34208 CNV Gain 17911159
nsv818937 CNV Gain 17921354
nsv832552 CNV Gain 17160897
nsv826546 CNV Gain 20364138

Variation tolerance for FZD10 Gene

Residual Variation Intolerance Score: 26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FZD10 Gene

HapMap Linkage Disequilibrium report
FZD10
Human Gene Mutation Database (HGMD)
FZD10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FZD10 Gene

Disorders for FZD10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FZD10 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
synovium cancer
  • malignant tumor of synovium
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search FZD10 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FZD10

Genetic Association Database (GAD)
FZD10
Human Genome Epidemiology (HuGE) Navigator
FZD10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FZD10
genes like me logo Genes that share disorders with FZD10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FZD10 Gene

Publications for FZD10 Gene

  1. Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family. (PMID: 10448064) Koike J. … Katoh M. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23 67
  2. Transcriptional profiling and Wnt signaling activation in proliferation of human hepatic stellate cells induced by PDGF-BB. (PMID: 20037267) Shin H.W. … Jang J.J. (Korean J Hepatol 2009) 3 23
  3. Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway. (PMID: 11786918) Terasaki H. … Katoh M. (Int. J. Mol. Med. 2002) 3 23
  4. Genome-wide association study of a quantitative disordered gambling trait. (PMID: 22780124) Lind P.A. … Slutske W.S. (Addict Biol 2013) 3
  5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3

Products for FZD10 Gene

Sources for FZD10 Gene

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