Aliases for FZD10 Gene
External Ids for FZD10 Gene
Previous GeneCards Identifiers for FZD10 Gene
This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008]
GeneCards Summary for FZD10 Gene
FZD10 (Frizzled Class Receptor 10) is a Protein Coding gene. Diseases associated with FZD10 include Deafness, Autosomal Dominant 41 and Deafness, Autosomal Dominant 25. Among its related pathways are PI3K-Akt signaling pathway and Gastric cancer. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and PDZ domain binding. An important paralog of this gene is FZD9.
UniProtKB/Swiss-Prot for FZD10 Gene
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.