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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FZD10 Gene

protein-coding   GIFtS: 64
GCID: GC12P130648

frizzled family receptor 10

(Previous names: frizzled (Drosophila) homolog 10, frizzled homolog 10 (Drosophila),...)
 Explore 15 diseases affiliated with
FZD10 via our new
 Human Malady Compendium 
Biological research products
for FZD10
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Frizzled Family Receptor 101 2     FZ-102
CD3501 2     Fz102
Frizzled 10, Seven Transmembrane Spanning Receptor1 2     Frizzled Homolog 102
FzE72 3     Frizzled-101
HFz101     Fz-103
Frizzled (Drosophila) Homolog 101     CD350 Antigen3
Frizzled Homolog 10 (Drosophila)1     

External Ids:    HGNC: 40391   Entrez Gene: 112112   Ensembl: ENSG000001114327   OMIM: 6061475   UniProtKB: Q9ULW23   

Export aliases for FZD10 gene to outside databases

Previous GC identifers: GC12P129076 GC12P130410 GC12P129000 GC12P129171 GC12P127632


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FZD10:
This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that
are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are
coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is
significantly up-regulated in two cases of primary colon cancer. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FZD10_HUMAN, Q9ULW2
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling
pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of
beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been
seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated
in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways
seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of
polarity information during tissue morphogenesis and/or in differentiated tissues

Gene Wiki entry for FZD10


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009755.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FZD10 gene promoter:
         TBP   RP58   TFIID   FOXO3a   FOXO3   Tal-1beta   FOXO3b   E47   c-Ets-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFZD10 promoter sequence
   Search SABiosciences Chromatin IP Primers for FZD10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FZD10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.33   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.33

FZD10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZD10 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P130648:  view genomic region     (about GC identifiers)

Start:
130,647,004 bp from pter      End:
130,650,285 bp from pter
Size:
3,282 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FZD10_HUMAN, Q9ULW2 (See protein sequence)
Recommended Name: Frizzled-10 precursor  
Size: 581 amino acids; 65336 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)

Explore the universe of human proteins at neXtProt for FZD10: NX_Q9ULW2

Post-translational modifications:

  • Ubiquitinated by ZNRF3, leading to its degradation by the proteasome (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9ULW2

  • FZD10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_009128.1  
    ENSEMBL proteins: 
     ENSP00000438460   ENSP00000229030  
    Reactome Protein details: Q9ULW2
    Human Recombinant Protein Products: 
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    Uscn Proteins for FZD10

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA16007199
    GO:0005886plasma membrane IBA--
    GO:0005887integral to plasma membrane TAS10448064
    GO:0009986cell surface IDA18271942
    GO:0042995cell projection IBA--


    FZD10 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FZD10 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000539 Frizzled
     IPR020067 Frizzled_dom
     IPR026549 FZD10
     IPR015526 Frizzled/SFRP
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry Q9ULW2

    ProtoNet protein and cluster: Q9ULW2

    1 Blocks protein family: IPB000539 Frizzled protein signature

    UniProtKB/Swiss-Prot: FZD10_HUMAN, Q9ULW2
    Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the
    activation of the Wnt/beta-catenin signaling pathway (By similarity)
    Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
    Similarity: Belongs to the G-protein coupled receptor Fz/Smo family
    Similarity: Contains 1 FZ (frizzled) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: FZD10_HUMAN, Q9ULW2
    Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling
    pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of
    beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been
    seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated
    in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways
    seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of
    polarity information during tissue morphogenesis and/or in differentiated tissues

         Genatlas biochemistry entry for FZD10:
    Drosophila frizzled polarity gene homolog 10,G protein coupled receptor superfamily,exhibiting characteristics of a WNT
    receptor,expressed in placenta fetal kidney,fetal lung brain,involved in signal transduction

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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005515protein binding IPI15930302
    GO:0017147Wnt-protein binding IBA--
    GO:0030165PDZ domain binding IBA--
    GO:0042813Wnt-activated receptor activity IBA--


    FZD10 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for FZD10:
     Decreased circadian period len  Increased Salmonella enterica   Increased gamma-H2AX phosphory 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Fzd10):
     normal 

    FZD10 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/18 super-pathways (see all 18About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt Signaling Pathway
    Wnt Signaling Pathway1.00
    Wnt Signaling Pathway0.33
    Wnt Signaling Pathway and Pluripotency0.55
    Wnt signaling pathway0.30
    2Translation_Non-genomic (rapid) action of Androgen Receptor
    Translation_Non-genomic (rapid) action of Androgen Receptor1.00
    Translation Non-genomic (rapid) action of Androgen Receptor0.99
    3Transcription_Androgen Receptor nuclear signaling
    Transcription_Androgen Receptor nuclear signaling1.00
    Transcription Androgen Receptor nuclear signaling0.99
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency1.00
    GSK3 Signaling0.61
    5Human Embryonic Stem Cell Pluripotency
    Human Embryonic Stem Cell Pluripotency1.00
    Factors Promoting Cardiogenesis in Vertebrates0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for FZD10
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 R&D Systems Pathway for FZD10
        Wnt Signaling Pathway

    5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FZD10 (see all 11)
        Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Colorectal Cancer Metastasis
    Glioblastoma Multiforme

    2 GeneGo (Thomson Reuters) Pathways for FZD10
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    3 BioSystems Pathways for FZD10 
        Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway
    Wnt signaling network

    4        Reactome Pathways for FZD10
        Signal Transduction
    Signaling by GPCR
    GPCR ligand binding
    Class B/2 (Secretin family receptors)


    4         Kegg Pathways  (Kegg details for FZD10):
        Wnt signaling pathway
    Melanogenesis
    Pathways in cancer
    Basal cell carcinoma


    FZD10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FZD10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/36 Interacting proteins for FZD10 (Q9ULW23 ENSP000002290304) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    LRP5O751973, ENSP000002943044I2D: score=1 STRING: ENSP00000294304
    WNT7BP567063, ENSP000003410324I2D: score=1 STRING: ENSP00000341032
    DVL1ENSP000003681694STRING: ENSP00000368169
    DVL2ENSP000000053404STRING: ENSP00000005340
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001944vasculature development IBA--
    GO:0007420brain development IBA--
    GO:0008406gonad development IBA--
    GO:0009790embryo development IBA--
    GO:0016055Wnt receptor signaling pathway ----


    FZD10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FZD10

    1 HMDB Compound for FZD10    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about FZD10 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FZD10 gene: 
    NM_007197.3  

    Unigene Cluster for FZD10:

    Frizzled family receptor 10
    Hs.733275  [show with all ESTs]
    Unigene Representative Sequence: BC070037
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000539839(uc001uii.3) ENST00000229030

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    hsa-miR-520f hsa-miR-15a hsa-miR-1258 hsa-miR-25 hsa-miR-424 hsa-miR-186 hsa-miR-15b hsa-miR-92b
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    Additional cDNA sequence: 

    AB027464.1 BC070037.1 BC074997.2 BC074998.2 

    1 DOTS entry:

    DT.444043 

    24/39 AceView cDNA sequences (see all 39):

    NM_007197 BC074997 BF110876 AI445929 AW517834 BC074998 CR606242 AI091125 
    AW513487 BC070037 AW074755 BX391916 AA291368 CK002027 BX369528 AA477826 
    AI697875 AB027464 BX096836 AA581479 BX369527 AA340556 AL578523 BE349959 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FZD10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTCCACTATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See FZD10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FZD10

    SOURCE GeneReport for Unigene cluster: Hs.733275

    UniProtKB/Swiss-Prot: FZD10_HUMAN, Q9ULW2
    Tissue specificity: Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain,
    abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total
    brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart, lung, skeletal muscle,
    pancreas, spleen and prostate

        SABiosciences Expression via Pathway-Focused PCR Array including FZD10: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FZD10 gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves FZD101 frizzled family receptor 10 77.66(n)
    90.37(a)
      373885  NM_204098.1  NP_989429.1 
    lizard
    (Anolis carolinensis)
    Reptilia FZD106
    --
    85(a)
    1 ↔ 1
    LGb(173812-175467)
    African clawed frog
    (Xenopus laevis)
    Amphibia fzd10b2 frizzled 10B 80.46(n)    AF159107.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fzd102 frizzled homolog 10 77.59(n)   30366  AF117388.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fz43 signal transduction transmembrane receptor 28(a)   6F5   --
    worm
    (Caenorhabditis elegans)
    Secernentea mom-53 Drosophila tissue polarity protein like 35(a)
    (best of 2)
      I(9973695-9977388)   --


    ENSEMBL Gene Tree for FZD10 (if available)
    TreeFam Gene Tree for FZD10 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FZD10 gene
    FZD32  FZD82  FZD12  FZD52  FZD22  FZD92  SFRP42  SMO2  
    FZD42  FZD62  SFRP12  FRZB2  FZD72  SFRP52  SFRP22  
    10 SIMAP similar genes for FZD10 using alignment to 3 protein entries:     FZD10_HUMAN (see all proteins):
    FZD9    GPCR    FZD4    FZD1    FZD2    FZD7
    FZD5    FZD6    FZD3    FZD8

    FZD10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/89 NCBI SNPs in FZD10 are shown (see all 89    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1851463241,2
    --130645015(+) ACCTTA/CTTTTT 2 -- us2k1 int10--------
    rs79708961,2
    C,F,A,H,--130645371(+) TCCCCA/CCCGCG 2 -- us2k1 nc-transcript-variant8Minor allele frequency- C:0.41NA WA EA 370
    rs1882460941,2
    --130645379(+) GCGGGA/GGCCCG 2 -- nc-transcript-variantus2k10--------
    rs1472370921,2
    C,--130645734(+) TTGGC-/GGGGTGG 2 -- us2k1 nc-transcript-variant0--------
    rs768283641,2
    C,F,--130646060(+) AAATAC/ACCCAC 2 -- us2k1 nc-transcript-variant2Minor allele frequency- A:0.14NA EA 240
    rs12583581,2
    C,F,H--130646131(-) GCCTCG/TCGCCA 2 -- us2k1 nc-transcript-variant11Minor allele frequency- T:0.01NA MN NS 1196
    rs110607521,2
    F,--130646503(+) GGGACT/GCACCA 2 -- us2k1 tfbs31Minor allele frequency- G:0.07EA 120
    rs18751211,2
    C,F,A,H,--130647349(-) CGCTGT/CGCACA 2 -- ut51 us2k1 ese35Minor allele frequency- C:0.36NA EA 128
    rs2021817941,2
    --130647554(+) TCAGCA/TCCATG 3 T S mis1 us2k10--------
    rs2012083111,2
    --130647555(+) CAGCTA/CCATGG 3 Y S mis1 us2k10--------

    HapMap Linkage Disequilibrium report for FZD10 (130647004 - 130650285 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for FZD10
         4 CNVs: 8740 3000 9700 3901

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FZD10 for disorders           About GeneDecksing

    OMIM gene information: 606147    OMIM disorders: --

    15 diseases for FZD10:    About MalaCards
    colon cancer    synovial sarcoma    basal cell carcinoma    renal cell carcinoma
    esophageal carcinoma    sarcoma    esophagitis    colorectal cancer
    carcinoma    cerebritis    hypoxia    hepatitis
    prostatitis    neuronitis    glioblastoma

    1 disease from the University of Copenhagen DISEASES database for FZD10:
    Synovial sarcoma

    3 Novoseek disease relationships for FZD10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cervical cancer 55 3 10448064 (1), 11743650 (1)
    colon cancer 41.6 2 10448064 (1), 11786918 (1)
    cancer 11.3 4 10448064 (1), 11743650 (1), 11786918 (1)

    Human Genome Epidemiology (HuGE) Navigator: FZD10 (1 document)

    Export disorders for FZD10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FZD10 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with FZD10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family. (PubMed id 10448064)1, 2, 3, 9 Koike J.... Katoh M. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. (PubMed id 9707618)1, 2 Tanaka S.... Sugimachi K. (1998)
    4. Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway. (PubMed id 11786918)1, 9 Terasaki H....Katoh M. (2002)
    5. Transcriptional profiling and Wnt signaling activatio n in proliferation of human hepatic stellate cells induced by PDGF-BB. (PubMed id 20037267)1, 9 Shin H.W....Jang J.J. (2009)
    6. Genome-wide association study of a quantitative disord ered gambling trait. (PubMed id 22780124)1 Lind P.A....Slutske W.S. (2012)
    7. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    8. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1 Jugessur A....Murray J.C. (2010)
    9. Development of a bioassay for detection of Wnt-bindin g affinities for individual frizzled receptors. (PubMed id 20227380)1 Carmon K.S. and Loose D.S. (2010)
    10. Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma. (PubMed id 19137009)1 Fukukawa C....Katagiri T. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11211 HGNC: 4039 AceView: FZD10 Ensembl:ENSG00000111432 euGenes: HUgn11211
    ECgene: FZD10 Kegg: 11211 H-InvDB: FZD10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FZD10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FZD10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FZD10 gene:
    Search GeneIP for patents involving FZD10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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