Aliases for FZD10 Gene
External Ids for FZD10 Gene
Previous GeneCards Identifiers for FZD10 Gene
This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008]
GeneCards Summary for FZD10 Gene
FZD10 (Frizzled Class Receptor 10) is a Protein Coding gene. Diseases associated with FZD10 include Deafness, Autosomal Dominant 41 and Deafness, Autosomal Dominant 25. Among its related pathways are Transcription Androgen Receptor nuclear signaling and Endometrial cancer. GO annotations related to this gene include G-protein coupled receptor activity and PDZ domain binding. An important paralog of this gene is FZD9.
UniProtKB/Swiss-Prot for FZD10 Gene
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.