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FZD10 Gene

protein-coding   GIFtS: 63
GCID: GC12P130648

Frizzled Class Receptor 10

(Previous names: frizzled (Drosophila) homolog 10, frizzled homolog 10 (Drosophila),...)
  See FZD10-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Frizzled Class Receptor 101 2     CD3502
Frizzled 10, Seven Transmembrane Spanning Receptor1 2     FZ-102
Frizzled Family Receptor 101 2     Fz102
FzE72 3     Frizzled Homolog 102
hFz102 3     frizzled-102
Frizzled (Drosophila) Homolog 101     Fz-103
Frizzled Homolog 10 (Drosophila)1     CD350 Antigen3

External Ids:    HGNC: 40391   Entrez Gene: 112112   Ensembl: ENSG000001114327   OMIM: 6061475   UniProtKB: Q9ULW23   

Export aliases for FZD10 gene to outside databases

Previous GC identifers: GC12P129076 GC12P130410 GC12P129000 GC12P129171 GC12P127632


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FZD10 Gene:
This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins
that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled
receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this
intronless gene is significantly up-regulated in two cases of primary colon cancer. (provided by RefSeq, Jul
2008)

GeneCards Summary for FZD10 Gene:
FZD10 (frizzled class receptor 10) is a protein-coding gene. Diseases associated with FZD10 include colon cancer, and cervical cancer. GO annotations related to this gene include Wnt-protein binding and G-protein coupled receptor activity. An important paralog of this gene is FZD3.

UniProtKB/Swiss-Prot: FZD10_HUMAN, Q9ULW2
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical
signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear
accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and
calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway
or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of
GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and
intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues

Gene Wiki entry for FZD10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the FZD10 gene promoter:
         TBP   RP58   TFIID   FOXO3a   FOXO3   Tal-1beta   FOXO3b   E47   c-Ets-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFZD10 promoter sequence
   Search Chromatin IP Primers for FZD10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FZD10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.33   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.33

FZD10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZD10 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P130648:  view genomic region     (about GC identifiers)

Start:
130,647,004 bp from pter      End:
130,650,285 bp from pter
Size:
3,282 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FZD10_HUMAN, Q9ULW2 (See protein sequence)
Recommended Name: Frizzled-10 precursor  
Size: 581 amino acids; 65336 Da

Explore the universe of human proteins at neXtProt for FZD10: NX_Q9ULW2

Explore proteomics data for FZD10 at MOPED

Post-translational modifications: 

  • Ubiquitinated by ZNRF3, leading to its degradation by the proteasome (By similarity)1
  • Glycosylation2 at Asn48, Asn153, Asn485

  • See FZD10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009128.1  
    ENSEMBL proteins: 
     ENSP00000438460   ENSP00000229030  
    Reactome Protein details: Q9ULW2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    FZD: GPCR / Class F : Frizzled receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: FZD10
    Frizzled Class GPCRs

    5 InterPro protein domains:
     IPR000539 Frizzled
     IPR020067 Frizzled_dom
     IPR026549 FZD10
     IPR015526 Frizzled/SFRP
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry Q9ULW2

    ProtoNet protein and cluster: Q9ULW2

    1 Blocks protein domain: IPB000539 Frizzled protein signature

    UniProtKB/Swiss-Prot: FZD10_HUMAN, Q9ULW2
    Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in
    the activation of the Wnt/beta-catenin signaling pathway (By similarity)
    Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
    Similarity: Belongs to the G-protein coupled receptor Fz/Smo family
    Similarity: Contains 1 FZ (frizzled) domain


    Find genes that share domains with FZD10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FZD10_HUMAN, Q9ULW2
    Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical
    signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear
    accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and
    calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway
    or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of
    GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and
    intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues

         Genatlas biochemistry entry for FZD10:
    Drosophila frizzled polarity gene homolog 10,G protein coupled receptor superfamily,exhibiting characteristics of
    a WNT receptor,expressed in placenta fetal kidney,fetal lung brain,involved in signal transduction

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005515protein binding IPI15930302
    GO:0017147Wnt-protein binding IBA--
    GO:0030165PDZ domain binding IBA--
         
    Find genes that share ontologies with FZD10           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for FZD10:
     Decreased circadian period len  Increased Salmonella enterica   Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Fzd10):
     normal 

    Find genes that share phenotypes with FZD10           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FZD10
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    Selected qRT-PCR Assays for microRNAs that regulate FZD10 (see all 32):
    hsa-miR-520f hsa-miR-15a hsa-miR-1258 hsa-miR-25 hsa-miR-424 hsa-miR-186 hsa-miR-15b hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidFZD10 3' UTR sequence
    Inhib. RNA
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    eBioscience FlowRNA Probe Sets ( VA1-11836) for FZD10 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FZD10_HUMAN, Q9ULW2: Cell membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus3
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA16007199
    GO:0005886plasma membrane IBA--
    GO:0005887integral component of plasma membrane TAS10448064
    GO:0009986cell surface IDA18271942
    GO:0016020membrane ----

    Find genes that share ontologies with FZD10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FZD10 About   (see all 21)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathways0.40
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    GSK3 Signaling0.61
    4Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    Wnt Signaling Pathway and Pluripotency0.55
    5Human Embryonic Stem Cell Pluripotency
    Factors Promoting Cardiogenesis in Vertebrates0.50
    Human Embryonic Stem Cell Pluripotency0.50


    Find genes that share SuperPaths with FZD10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for FZD10
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FZD10 (see all 11)
        Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Colorectal Cancer Metastasis
    Glioblastoma Multiforme

    2 GeneGo (Thomson Reuters) Pathways for FZD10
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    3 BioSystems Pathways for FZD10
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    Wnt signaling network


    1 Reactome Pathway for FZD10
        Class B/2 (Secretin family receptors)


    Selected Kegg Pathways  (Kegg details for FZD10) (see all 7):
        Wnt signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection
    Pathways in cancer

        Pathway & Disease-focused RT2 Profiler PCR Array including FZD10: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FZD10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FZD10 (Q9ULW21, 3 ENSP000002290304) via UniProtKB, MINT, STRING, and/or I2D (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    WNT7BP567063, ENSP000003410324I2D: score=1 STRING: ENSP00000341032
    LRP5O751973, ENSP000002943044I2D: score=1 STRING: ENSP00000294304
    HILPDAQ9Y5L21EBI-8803802,EBI-8803836
    GNAO1ENSP000002624934STRING: ENSP00000262493
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001944vasculature development IBA--
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007420brain development IBA--
    GO:0008406gonad development IBA--
    GO:0009790embryo development IBA--

    Find genes that share ontologies with FZD10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FZD10

    1 HMDB Compound for FZD10    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FZD10 gene: 
    NM_007197.3  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000539839(uc001uii.3) ENST00000229030
    miRNA
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    Selected AceView cDNA sequences (see all 39):

    BC074997 BC074998 AW517834 NM_007197 CR606242 AI445929 BF110876 BC070037 
    AA478225 BX096836 AW074755 AA581479 AB027464 AW513487 BX369527 AI697875 
    BE349959 BG898982 CK002027 AA477826 BX391916 C02429 AL578523 AL556202 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FZD10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCACTATT
    FZD10 Expression
    About this image


    FZD10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Epithalamus
     
     Epithelial Cells
             Basal Keratinocytes Embryonic Epidermis
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Hair
             Basal Keratinocytes Embryonic Epidermis
    FZD10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FZD10 Protein Expression

    UniProtKB/Swiss-Prot: FZD10_HUMAN, Q9ULW2
    Tissue specificity: Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult
    brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low
    levels in total brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart,
    lung, skeletal muscle, pancreas, spleen and prostate

        Pathway & Disease-focused RT2 Profiler PCR Array including FZD10: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FZD10 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fzd101 , 5 frizzled homolog 10 (Drosophila)1, 5 87.09(n)1
    92.94(a)1
      5 (67.67 cM)5
    938971  NM_175284.31  NP_780493.11 
     1286008445 
    chicken
    (Gallus gallus)
    Aves FZD101 frizzled family receptor 10 77.07(n)
    89.01(a)
      373885  NM_204098.2  NP_989429.1 
    lizard
    (Anolis carolinensis)
    Reptilia FZD106
    frizzled family receptor 10
    85(a)
    1 ↔ 1
    LGb(173812-175467)
    African clawed frog
    (Xenopus laevis)
    Amphibia fzd10b2 frizzled 10B 80.46(n)    AF159107.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fzd102 frizzled homolog 10 77.59(n)   30366  AF117388.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fz43 signal transduction transmembrane
    receptor
    28(a)   6F5   --


    ENSEMBL Gene Tree for FZD10 (if available)
    TreeFam Gene Tree for FZD10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for FZD10 gene
    FZD32  FZD82  FZD12  FZD52  FZD22  FZD92  SFRP42  SMO2  
    FZD42  FZD62  SFRP12  FRZB2  SFRP52  FZD72  SFRP22  
    10 SIMAP similar genes for FZD10 using alignment to 3 protein entries:     FZD10_HUMAN (see all proteins):
    FZD9    GPCR    FZD4    FZD1    FZD2    FZD7
    FZD5    FZD6    FZD3    FZD8

    Find genes that share paralogs with FZD10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FZD10 (see all 92)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1808867091,2
    --127630004(+) ACAAAA/CAACAA 1 -- us2k10--------
    rs2005579971,2
    --127630013(+) ACAAC-/AAACAA 1 -- us2k10--------
    rs14638661,2
    A--127630016(-) TTTTTG/TTTGTT 1 -- us2k10--------
    rs2010582961,2
    --127630016(+) AACAA-/CAAAAA 1 -- us2k10--------
    rs614972831,2
    C,F--127630019(+) AACAAC/AAAAAA 1 -- us2k12Minor allele frequency- A:0.50NA 6
    rs679980601,2
    C--127630020(+) AACAA-/A/AA/C
            
    AAAAA
    1 -- us2k11NA 2
    rs1175107591,2
    C,F--127630061(+) AAATAA/GAATCA 1 -- us2k11Minor allele frequency- G:0.03NA 120
    rs586075621,2
    C--130644898(+) ACAAC-/AAAAAA 1 -- int11Minor allele frequency- A:0.00CSA 2
    rs801905921,2
    C,F--130648246(+) GACCCG/CGCCCG 2 /P syn12Minor allele frequency- C:0.02NA EU 5873
    rs2006182491,2
    --130648264(+) TACCCC/GGAGCG 2 P syn10--------

    HapMap Linkage Disequilibrium report for FZD10 (130647004 - 130650285 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FZD10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34208CNV Gain17911159
    nsv826546CNV Gain20364138
    nsv832552CNV Gain17160897
    nsv818937CNV Gain17921354
    dgv533e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FZD10
    DNA2.0 Custom Variant and Variant Library Synthesis for FZD10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606147    OMIM disorders: --

    2 diseases for FZD10:    
    About MalaCards
    colon cancer    cervical cancer

    1 disease from the University of Copenhagen DISEASES database for FZD10:
    Synovial sarcoma

    Find genes that share disorders with FZD10           About GenesLikeMe

    3 Novoseek inferred disease relationships for FZD10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cervical cancer 55 3 10448064 (1), 11743650 (1)
    colon cancer 41.6 2 10448064 (1), 11786918 (1)
    cancer 11.3 4 10448064 (1), 11743650 (1), 11786918 (1)

    Genetic Association Database (GAD): FZD10
    Human Genome Epidemiology (HuGE) Navigator: FZD10 (1 document)

    Export disorders for FZD10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FZD10 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with FZD10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family. (PubMed id 10448064)1, 2, 3, 9 Koike J.... Katoh M. (Biochem. Biophys. Res. Commun. 1999)
    2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. (PubMed id 9707618)1, 2 Tanaka S.... Sugimachi K. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    5. Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway. (PubMed id 11786918)1, 9 Terasaki H....Katoh M. (Int. J. Mol. Med. 2002)
    6. Transcriptional profiling and Wnt signaling activation in proliferation of human hepatic stellate cells induced by PDGF-BB. (PubMed id 20037267)1, 9 Shin H.W....Jang J.J. (Korean J Hepatol 2009)
    7. Genome-wide association study of a quantitative disordered gambling trait. (PubMed id 22780124)1 Lind P.A....Slutske W.S. (Addict Biol 2013)
    8. Development of a bioassay for detection of Wnt-binding affinities for individual frizzled receptors. (PubMed id 20227380)1 Carmon K.S. and Loose D.S. (Anal. Biochem. 2010)
    9. Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma. (PubMed id 19137009)1 Fukukawa C....Katagiri T. (Oncogene 2009)
    10. Inverse correlation of the up-regulation of FZD10 expression and the activation of beta-catenin in synchronous colorectal tumors. (PubMed id 19134005)1 Nagayama S....Toguchida J. (Cancer Sci. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11211 HGNC: 4039 AceView: FZD10 Ensembl:ENSG00000111432 euGenes: HUgn11211
    ECgene: FZD10 Kegg: 11211 H-InvDB: FZD10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FZD10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FZD10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FZD10 gene:
    Search GeneIP for patents involving FZD10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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