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Aliases for FZD10 Gene

Aliases for FZD10 Gene

  • Frizzled Class Receptor 10 2 3
  • Frizzled 10, Seven Transmembrane Spanning Receptor 2 3
  • Frizzled Family Receptor 10 2 3
  • FZ-10 3 4
  • HFz10 3 4
  • FzE7 3 4
  • Frizzled (Drosophila) Homolog 10 2
  • Frizzled Homolog 10 (Drosophila) 2
  • Frizzled Homolog 10 3
  • CD350 Antigen 4
  • Frizzled-10 3
  • CD350 3
  • Fz10 3

External Ids for FZD10 Gene

Summaries for FZD10 Gene

Entrez Gene Summary for FZD10 Gene

  • This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for FZD10 Gene

FZD10 (Frizzled Class Receptor 10) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include G-protein coupled receptor activity and Wnt-protein binding. An important paralog of this gene is FZD1.

UniProtKB/Swiss-Prot for FZD10 Gene

  • Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues

Gene Wiki entry for FZD10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FZD10 Gene

Genomics for FZD10 Gene

Genomic Location for FZD10 Gene

Start:
130,162,459 bp from pter
End:
130,165,740 bp from pter
Size:
3,282 bases
Orientation:
Plus strand

Genomic View for FZD10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FZD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FZD10 Gene

Regulatory Elements for FZD10 Gene

Proteins for FZD10 Gene

  • Protein details for FZD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULW2-FZD10_HUMAN
    Recommended name:
    Frizzled-10
    Protein Accession:
    Q9ULW2
    Secondary Accessions:

    Protein attributes for FZD10 Gene

    Size:
    581 amino acids
    Molecular mass:
    65336 Da
    Quaternary structure:
    • Interacts with MYOC.

neXtProt entry for FZD10 Gene

Proteomics data for FZD10 Gene at MOPED

Post-translational modifications for FZD10 Gene

  • Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
  • Glycosylation at Asn48, Asn153, and Asn485

Other Protein References for FZD10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FZD10 Gene

Domains for FZD10 Gene

Gene Families for FZD10 Gene

HGNC:
  • CD :CD molecules
  • FZD :GPCR / Class F : Frizzled receptors
IUPHAR :

Protein Domains for FZD10 Gene

Suggested Antigen Peptide Sequences for FZD10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULW2

UniProtKB/Swiss-Prot:

FZD10_HUMAN
Domain:
  • Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.:
    • Q9ULW2
  • The FZ domain is involved in binding with Wnt ligands.:
    • Q9ULW2
  • Contains 1 FZ (frizzled) domain.:
    • Q9ULW2
Family:
  • Belongs to the G-protein coupled receptor Fz/Smo family.:
    • Q9ULW2
genes like me logo Genes that share domains with FZD10: view

Function for FZD10 Gene

Molecular function for FZD10 Gene

GENATLAS Biochemistry: Drosophila frizzled polarity gene homolog 10,G protein coupled receptor superfamily,exhibiting characteristics of a WNT receptor,expressed in placenta fetal kidney,fetal lung brain,involved in signal transduction
UniProtKB/Swiss-Prot Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues

Gene Ontology (GO) - Molecular Function for FZD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity IBA --
GO:0005515 protein binding IPI 15930302
GO:0017147 Wnt-protein binding IBA --
GO:0030165 PDZ domain binding --
genes like me logo Genes that share ontologies with FZD10: view
genes like me logo Genes that share phenotypes with FZD10: view

miRNA for FZD10 Gene

miRTarBase miRNAs that target FZD10

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FZD10 Gene

Localization for FZD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FZD10 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FZD10 Gene COMPARTMENTS Subcellular localization image for FZD10 gene
Compartment Confidence
plasma membrane 5
nucleus 3
extracellular 1

Gene Ontology (GO) - Cellular Components for FZD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16007199
GO:0005886 plasma membrane --
GO:0005887 integral component of plasma membrane TAS 10448064
GO:0009986 cell surface IDA 18271942
GO:0016020 membrane --
genes like me logo Genes that share ontologies with FZD10: view

Pathways for FZD10 Gene

genes like me logo Genes that share pathways with FZD10: view

Gene Ontology (GO) - Biological Process for FZD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001944 vasculature development --
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007420 brain development --
GO:0008406 gonad development --
genes like me logo Genes that share ontologies with FZD10: view

Compounds for FZD10 Gene

(1) HMDB Compounds for FZD10 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with FZD10: view

Transcripts for FZD10 Gene

mRNA/cDNA for FZD10 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(39) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FZD10 Gene

Frizzled family receptor 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FZD10 Gene

No ASD Table

Relevant External Links for FZD10 Gene

GeneLoc Exon Structure for
FZD10
ECgene alternative splicing isoforms for
FZD10

Expression for FZD10 Gene

mRNA expression in normal human tissues for FZD10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FZD10 Gene

This gene is overexpressed in Esophagus - Mucosa (9.7), Skin - Not Sun Exposed (Suprapubic) (5.6), Skin - Sun Exposed (Lower leg) (4.9), and Cervix - Endocervix (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FZD10 Gene

SOURCE GeneReport for Unigene cluster for FZD10 Gene Hs.733275

mRNA Expression by UniProt/SwissProt for FZD10 Gene

Q9ULW2-FZD10_HUMAN
Tissue specificity: Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate
genes like me logo Genes that share expressions with FZD10: view

Orthologs for FZD10 Gene

This gene was present in the common ancestor of animals.

Orthologs for FZD10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FZD10 35
  • 99.54 (n)
  • 99.83 (a)
FZD10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FZD10 35
  • 91.91 (n)
  • 95.01 (a)
FZD10 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FZD10 35
  • 92.48 (n)
  • 95.01 (a)
FZD10 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fzd10 35
  • 87.09 (n)
  • 92.94 (a)
Fzd10 16
Fzd10 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FZD10 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fzd10 35
  • 86.98 (n)
  • 92.94 (a)
chicken
(Gallus gallus)
Aves FZD10 35
  • 77.07 (n)
  • 89.01 (a)
FZD10 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FZD10 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia fzd10b 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fzd10 35
  • 77.41 (n)
  • 85.64 (a)
Str.154 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13569 35
zebrafish
(Danio rerio)
Actinopterygii fzd10 35
  • 71.45 (n)
  • 77.48 (a)
fzd10 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta fz2 36
  • 35 (a)
OneToMany
fz4 37
  • 28 (a)
worm
(Caenorhabditis elegans)
Secernentea mom-5 37
  • 35 (a)
cfz-2 37
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToMany
Species with no ortholog for FZD10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FZD10 Gene

ENSEMBL:
Gene Tree for FZD10 (if available)
TreeFam:
Gene Tree for FZD10 (if available)

Paralogs for FZD10 Gene

Paralogs for FZD10 Gene

Selected SIMAP similar genes for FZD10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FZD10: view

Variants for FZD10 Gene

Sequence variations from dbSNP and Humsavar for FZD10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1046890 -- 130,165,225(+) GACTC(C/T)GGCCT utr-variant-3-prime
rs1046893 -- 130,165,471(+) TAGAC(C/G)TTTGG utr-variant-3-prime
rs1046895 -- 130,165,496(+) AGGAG(A/G)GGGGA utr-variant-3-prime
rs3741568 -- 130,165,417(-) CTGAA(A/G)GGTTT utr-variant-3-prime
rs3832815 -- 130,165,306(-) AAAAA(-/A)TGTAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FZD10 Gene

Variant ID Type Subtype PubMed ID
dgv533e1 CNV Complex 17122850
esv34208 CNV Gain 17911159
nsv818937 CNV Gain 17921354
nsv832552 CNV Gain 17160897
nsv826546 CNV Gain 20364138

Relevant External Links for FZD10 Gene

HapMap Linkage Disequilibrium report
FZD10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FZD10 Gene

Disorders for FZD10 Gene

(1) University of Copenhagen DISEASES for FZD10 Gene

(3) Novoseek inferred disease relationships for FZD10 Gene

Disease -log(P) Hits PubMed IDs
cervical cancer 55 2
colon cancer 41.6 2
cancer 11.3 3

Relevant External Links for FZD10

Genetic Association Database (GAD)
FZD10
Human Genome Epidemiology (HuGE) Navigator
FZD10
genes like me logo Genes that share disorders with FZD10: view

No data available for UniProtKB/Swiss-Prot for FZD10 Gene

Publications for FZD10 Gene

  1. Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family. (PMID: 10448064) Koike J. … Katoh M. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23
  2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 48
  3. Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway. (PMID: 11786918) Terasaki H. … Katoh M. (Int. J. Mol. Med. 2002) 3 23
  4. Transcriptional profiling and Wnt signaling activation in proliferation of human hepatic stellate cells induced by PDGF-BB. (PMID: 20037267) Shin H.W. … Jang J.J. (Korean J Hepatol 2009) 3 23
  5. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. (PMID: 9707618) Tanaka S. … Sugimachi K. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4

Products for FZD10 Gene

Sources for FZD10 Gene

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