Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FZD1 Gene

protein-coding   GIFtS: 67
GCID: GC07P090893

frizzled family receptor 1

(Previous names: frizzled (Drosophila) homolog 1, frizzled homolog 1 (Drosophila),...)
 Explore 16 diseases affiliated with
FZD1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FZD1    

Aliases
for FZD1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Frizzled Family Receptor 11 2     Frizzled, Drosophila, Homolog Of, 12
Frizzled 1, Seven Transmembrane Spanning Receptor1 2     Frizzled-11
HFz11     Fz-13
DKFZp564G0721     FzE13
Frizzled (Drosophila) Homolog 11     Wnt Receptor2
Frizzled Homolog 1 (Drosophila)1     Fz-13
Frizzled Homolog 12     FzE13

External Ids:    HGNC: 40381   Entrez Gene: 83212   Ensembl: ENSG000001572407   OMIM: 6034085   UniProtKB: Q9UP383   

Export aliases for FZD1 gene to outside databases

Previous GC identifers: GC07P089429 GC07P090491 GC07P090505 GC07P090538 GC07P090731 GC07P085501


Summaries
for FZD1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FZD1:
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling
proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7
transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FZD1_HUMAN, Q9UP38
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling
pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of
beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been
seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated
in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways
seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of
polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and
to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B

Gene Wiki entry for FZD1


Genomic Views
for FZD1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FZD1 gene promoter:
         Pax-5   AML1a   NRSF form 1   HSF1 (long)   Nkx2-5   NRSF form 2   C/EBPalpha   Egr-2   HSF1short   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FZD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FZD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FZD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21   Ensembl cytogenetic band:  7q21.13   HGNC cytogenetic band: 7q21

FZD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZD1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P090893:  view genomic region     (about GC identifiers)

Start:
 90,893,783 bp from pter      End:
 90,898,132 bp from pter
Size:
 4,350 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 90,224,254-90,228,603     

Proteins
for FZD1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FZD1_HUMAN, Q9UP38 (See protein sequence)
Recommended Name: Frizzled-1 precursor  
Size: 647 amino acids; 71158 Da
Subcellular location: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: A4D1E8 O94815 Q549T8

Explore the universe of human proteins at neXtProt for FZD1: NX_Q9UP38

Post-translational modifications:

  • Ubiquitinated by ZNRF3, leading to its degradation by the proteasome (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UP38

    • FZD1 Protein expression data from MOPED and PaxDb:    About this image 
    FZD1 Protein Expression
    REFSEQ proteins: NP_003496.1  
    ENSEMBL proteins: 
     ENSP00000287934  
    Reactome Protein details: Q9UP38
    Human Recombinant Protein Products for FZD1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FZD1 (Frizzled-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for FZD1 
    GenScript Custom Purified and Recombinant Proteins Services for FZD1
    Sino Biological Recombinant Protein for FZD1
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FZD1

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005886plasma membrane ----
    GO:0009986cell surface IDA19643732
    GO:0016021integral to membrane IEA--
    GO:0019717synaptosome ----

    FZD1 for ontologies           About GeneDecksing



    FZD1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FZD1 (Frizzled-1)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FZD1 
    GenScript Custom Superior Antibodies Services for FZD1
    Novus Biologicals FZD1 Antibodies
    Abcam antibodies for FZD1 
    Uscn Antibodies for FZD1
    ThermoFisher Antibodies for FZD1

    Assay Products for FZD1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FZD1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for FZD1

    Protein Domains /
    Families
    for FZD1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FZD1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000539 Frizzled
     IPR020067 Frizzled_dom
     IPR026548 FZD1
     IPR015526 Frizzled/SFRP
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry Q9UP38

    ProtoNet protein and cluster: Q9UP38

    1 Blocks protein family: IPB000539 Frizzled protein signature

    UniProtKB/Swiss-Prot: FZD1_HUMAN, Q9UP38
    Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the
    activation of the Wnt/beta-catenin signaling pathway (By similarity)
    Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
    Similarity: Belongs to the G-protein coupled receptor Fz/Smo family
    Similarity: Contains 1 FZ (frizzled) domain


    Function
    for FZD1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FZD1_HUMAN, Q9UP38
    Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling
    pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of
    beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been
    seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated
    in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways
    seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of
    polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and
    to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B

         Genatlas biochemistry entry for FZD1:
    Drosophila frizzled polarity gene homolog,G protein coupled receptor superfamily,exhibiting characteristics of a WNT
    receptor,expressed in heart,brain,placenta,lung,kidney,pancreas,prostate and ovary

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005102receptor binding IPI14739301
    GO:0005515protein binding IPI19277043
    GO:0017147Wnt-protein binding IPI10557084
    GO:0030165PDZ domain binding IPI19388021
         
    FZD1 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for FZD1:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella-containin  Decreased substrate adherent c 

         14 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Fzd1):
     cardiovascular system  craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     hearing/vestibular/ear  homeostasis/metabolism  integument  nervous system  normal 
     other  pigmentation  reproductive system  skeleton 

    FZD1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Fzd1tm1.1Boer for FZD1
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FZD1 

    miRNA
    Products:            		miRTarBase miRNAs that target FZD1:
    hsa-mir-204 (MIRT005827)

    OriGene 3'-UTR Clone: FZD1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FZD1
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate FZD1 (see all 38):
    hsa-miR-26a-2* hsa-miR-146a hsa-let-7a-2* hsa-miR-1273d hsa-miR-3163 hsa-miR-3606 hsa-miR-425 hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmid: FZD1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FZD1 (see all 7)
    OriGene shRNA RFP: FZD1
    OriGene siRNA: FZD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FZD1
    Sirion Biotech Custom design and validation of potent shRNA sequences against FZD1 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FZD1
    Sirion Biotech Customized adenovirus for overexpression of FZD1 
    Sirion Biotech Customized adenovirus for potent knockdown of FZD1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FZD1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FZD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: FZD1 (NM_003505)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FZD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FZD1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for FZD1
    Search LifeMap BioReagents cell lines for FZD1
    Sirion Biotech Customized stable knockdown cell line services for FZD1 
    Sirion Biotech Customized inducible knockdown cell line services for FZD1
    Sirion Biotech Customized stable overexpressing cell line services for FZD1
    Sirion Biotech Customized inducible overexpressing cell line services for FZD1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD1


    Pathways & Interactions
    for FZD1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/21 super-pathways (see all 21) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt Signaling Pathway
    		Wnt Signaling Pathway1.00
    		Wnt signaling pathway0.30
    		Wnt Signaling Pathway and Pluripotency0.55
    		Wnt Signaling Pathway NetPath0.22
    		Wnt Signaling Pathway0.33
    2Basal cell carcinoma
    		Basal cell carcinoma1.00
    		Melanogenesis0.32
    		Wnt Pathway0.37
    3Translation_Non-genomic (rapid) action of Androgen Receptor
    		Translation_Non-genomic (rapid) action of Androgen Receptor1.00
    		Translation Non-genomic (rapid) action of Androgen Receptor0.99
    4Transcription_Androgen Receptor nuclear signaling
    		Transcription_Androgen Receptor nuclear signaling1.00
    		Transcription Androgen Receptor nuclear signaling0.99
    5Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		GSK3 Signaling0.61

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for FZD1
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 R&D Systems Pathway for FZD1
        Wnt Signaling Pathway

    5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FZD1 (see all 11)
        Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Colorectal Cancer Metastasis
    Glioblastoma Multiforme

    1 Tocris Bioscience Pathway for FZD1
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for FZD1
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    5/7 BioSystems Pathways for FZD1 (see all 7) 
        Adipogenesis
    Wnt Signaling Pathway
    MicroRNAs in cardiomyocyte hypertrophy
    Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway NetPath

    4        Reactome Pathways for FZD1
        Signal Transduction
    Signaling by GPCR
    GPCR ligand binding
    Class B/2 (Secretin family receptors)


    4         Kegg Pathways  (Kegg details for FZD1):
        Wnt signaling pathway
    Melanogenesis
    Pathways in cancer
    Basal cell carcinoma


    FZD1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FZD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/63 Interacting proteins for FZD1 (Q9UP383 ENSP000002879344) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG4P783523, ENSP000002938134I2D: score=3 STRING: ENSP00000293813
    WNT4P567053, ENSP000002901674I2D: score=2 STRING: ENSP00000290167
    GNAO1P094713, ENSP000002624934I2D: score=1 STRING: ENSP00000262493
    WNT1P046283, ENSP000002935494I2D: score=1 STRING: ENSP00000293549
    WNT2P095443, ENSP000002654414I2D: score=1 STRING: ENSP00000265441
    About this table

    Gene Ontology (GO): 5/34 biological process terms (GO ID links to tree view) (see all 34):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation IEA--
    GO:0001944vasculature development IBA--
    GO:0003149membranous septum morphogenesis IEA--
    GO:0003150muscular septum morphogenesis IEA--
    GO:0003151outflow tract morphogenesis IEA--

    FZD1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FZD1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FZD1

    1 HMDB Compound for FZD1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about FZD1 

    Transcripts
    for FZD1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FZD1 gene: 
    NM_003505.1  

    Unigene Cluster for FZD1:

    Frizzled family receptor 1
    Hs.94234  [show with all ESTs]
    Unigene Representative Sequence: AB017363
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000287934(uc003ula.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: FZD1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FZD1
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate FZD1 (see all 38):
    hsa-miR-26a-2* hsa-miR-146a hsa-let-7a-2* hsa-miR-1273d hsa-miR-3163 hsa-miR-3606 hsa-miR-425 hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmid: FZD1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FZD1 (see all 7)
    OriGene shRNA RFP: FZD1
    OriGene siRNA: FZD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FZD1
    Sirion Biotech Custom design and validation of potent shRNA sequences against FZD1 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FZD1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FZD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: FZD1 (NM_003505)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FZD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FZD1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FZD1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FZD1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FZD1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FZD1

    Additional cDNA sequence: 

    AB017363.1 AF072872.1 AK314996.1 AL049994.1 BC017719.2 BC051271.1 

    4 DOTS entries:

    DT.453919  DT.92422830  DT.100657816  DT.92422832 

    24/63 AceView cDNA sequences (see all 63):

    CD518856 NM_003505 CA489698 AI084462 AA664127 AB017363 BM756600 BQ956211 
    BU176762 BG289570 BU176007 CR597493 BX433281 BM756060 BG751670 CB268931 
    BU627733 BG741346 AA158995 AL557392 BC051271 BP338536 CD518089 CD559153 

    GeneLoc Exon Structure


    Expression
    for FZD1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FZD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTAAAGGGAA
    FZD1 Expression
    About this image

    FZD1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    10/12 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 12) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    SomiteCervical DermomyotomeCervical Dermomyotome CellsAdipose, Skeletal Muscle
    SomiteCervical Dorsomedial Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    SomiteLumbar DermomyotomeLumbar Dermomyotome CellsAdipose, Skeletal Muscle
    SomiteLumbar Dorsomedial Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    SomiteSacral DermomyotomeSacral Dermomyotome CellsAdipose, Skeletal Muscle
    SomiteSacral Dorsomedial Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    SomiteThoracic DermomyotomeThoracic Dermomyotome CellsAdipose, Skeletal Muscle
    SomiteThoracic Dorsomedial Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    HeartEndocardiumCushion Mesenchymal CellsEndocardium
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage

    See FZD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FZD1

    SOURCE GeneReport for Unigene cluster: Hs.94234

    UniProtKB/Swiss-Prot: FZD1_HUMAN, Q9UP38
    Tissue specificity: Expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung
    and kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including FZD1 (see all 6): 
              G Protein Coupled Receptors 384HT in human mouse rat
              Primary Cilia in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat
              Stem Cells in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FZD1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FZD1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FZD1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FZD1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD1

    Orthologs
    for FZD1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FZD1 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FZD11 frizzled family receptor 1 83.85(n)
    90.48(a)    		   374062  NM_001030337.1  NP_001025508.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FZD16
    		 --
    		 89(a)
    		 1 ↔ 1
    		 6(20755209-20757079)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1947611 zgc:194761 79.9(n)
    83.78(a)    		   557384  NM_001130614.1  NP_001124086.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta fz3 determination of sensory organ precursor
    cell more    		 48(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea mom-51 , 3 Drosophila tissue polarity protein like3
    Protein MOM-51    		 39(a)3
    47.88(n)1
    42.43(a)1    		   I(9973695-9977388)3
    1728561  NM_060234.31  NP_492635.11 


    ENSEMBL Gene Tree for FZD1 (if available)
    TreeFam Gene Tree for FZD1 (if available) 

    Paralogs
    for FZD1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FZD1 gene
    FZD102  FZD32  FZD82  FZD52  FZD22  FZD92  SFRP42  SMO2  
    FZD42  FZD62  SFRP12  FRZB2  FZD72  SFRP52  SFRP22  
    10 SIMAP similar genes for FZD1 using alignment to 1 protein entry:     FZD1_HUMAN:
    FZD7    FZD2    GPCR    FZD6    FZD10    FZD3
    FZD5    FZD9    FZD4    FZD8

    FZD1 for paralogs           About GeneDecksing



    Genomic Variants
    for FZD1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/97 NCBI SNPs in FZD1 are shown (see all 97)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs106543961,2
    		C--90891788(+) CAATCAG/-AAATA 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1912848381,2
    		--90891808(+) AAAAAG/TGCATT 1 -- us2k10--------
    rs1834804671,2
    		--90891936(+) AACATC/GCTGGG 1 -- us2k10--------
    rs1898992041,2
    		--90892146(+) CAAACA/GTTTTA 1 -- us2k10--------
    rs1386712571,2
    		--90892166(+) AAAACC/TTTTTC 1 -- us2k10--------
    rs1811856981,2
    		--90892293(+) CATTTC/GATCTG 1 -- us2k10--------
    rs795310801,2
    		--90892391(+) CCTCTC/GTAAGG 1 -- us2k10--------
    rs113490251,2
    		C--90892547(+) CAGGC-/AAAAAA 1 -- us2k1 trp30--------
    rs1494928911,2
    		C--90892574(+) AATTA-/ATAGTCC 1 -- us2k10--------
    rs785219241,2
    		F--90892588(+) TGGCAC/TTTTTC 1 -- us2k11Minor allele frequency- T:0.02NA 120

    HapMap Linkage Disequilibrium report for FZD1 (90893783 - 90898132 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FZD1: --
    Human Gene Mutation Database (HGMD): FZD1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FZD1
    DNA2.0 Custom Variant and Variant Library Synthesis for FZD1

    Disorders / Diseases
    for FZD1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FZD1 for disorders           About GeneDecksing

    OMIM gene information: 603408    OMIM disorders: --

    16 diseases for FZD1:    About MalaCards
    exudative vitreoretinopathy    vitreoretinopathy    basal cell carcinoma    insulin resistance
    pulmonary fibrosis    esophageal carcinoma    fibrosis    esophagitis
    ovarian cancer    prostate cancer    carcinoma    prostatitis
    thyroiditis    neuronitis    colorectal cancer    glioblastoma

    Human Genome Epidemiology (HuGE) Navigator: FZD1 (6 documents)

    Export disorders for FZD1 gene to outside databases

    Publications
    for FZD1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FZD1 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with FZD1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7. (PubMed id 9813155)1, 2, 3, 9 Sagara N.... Katoh M. (1998)
    2. Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. (PubMed id 10557084)1, 2, 9 Gazit A....Aaronson S.A. (1999)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    6. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. (PubMed id 9707618)1, 2 Tanaka S.... Sugimachi K. (1998)
    7. Functional and association analysis of frizzled 1 (FZ D1) promoter haplotypes with femoral neck geometry. (PubMed id 20051274)1, 9 Zhang Y....Zmuda J.M. (2010)
    8. The Wnt receptor FZD1 mediates chemoresistance in neu roblastoma through activation of the Wnt/beta-catenin pathway. (PubMed id 19421142)1, 9 Flahaut M....Gross N. (2009)
    9. Canonical and noncanonical Wnt pathway: a comparison among normal ovary, benign ovarian tumor and ovarian cancer. (PubMed id 19148501)1, 9 Badiglian Filho L....GonAsalves W.J. (2009)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    External Searches for FZD1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FZD1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8321 HGNC: 4038 AceView: FZD1 Ensembl:ENSG00000157240 euGenes: HUgn8321
    ECgene: FZD1 Kegg: 8321 H-InvDB: FZD1

    Other Databases showing FZD1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FZD1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FZD1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FZD1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FZD1 gene:
    Search GeneIP for patents involving FZD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for FZD1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for FZD1 (Frizzled-1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for FZD1 (Frizzled-1)  
     Browse OriGene Antibodies   OriGene shRNA RFP for FZD1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FZD1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FZD1  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for FZD1   OriGene 3'-UTR Clone for FZD1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FZD1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FZD1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FZD1   OriGene Custom Protein Services for FZD1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FZD1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FZD1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FZD1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FZD1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FZD1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FZD1
     GenScript Custom Purified and Recombinant Proteins Services for FZD1 GenScript cDNA clones with any tag delivered in your preferred vector for FZD1
     GenScript Custom Assay Services for FZD1 GenScript Custom Superior Antibodies Services for FZD1
     GenScript Custom overexpressing Cell Line Services for FZD1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FZD1 promoter
     Search Chromatin IP Primers for FZD1
     RT2 qPCR Primer Assay in human, mouse, rat FZD1
     GNC Network for FZD1
     SABiosciences PCR Arrays including human, mouse, rat FZD1
     Search Tocris compounds for FZD1
     Proteins and Antibodies for FZD1
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FZD1 antibodies
     Antibodies for FZD1
     See all of Abcam's Antibodies, Kits and Proteins for FZD1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     FZD1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for FZD1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FZD1
     SwitchGear 3'UTR luciferase reporter plasmids for FZD1
     SwitchGear Promoter luciferase reporter plasmids for FZD1
     ThermoFisher Antibodies for FZD1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FZD1
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FZD1
    Sirion Biotech Customized:
     stable knockdown cell line services for FZD1
     inducible knockdown cell line services for FZD1
     design and validation of potent shRNA sequences against FZD1
     adenovirus for potent knockdown of FZD1
     adenovirus for overexpression of FZD1
     stable overexpressing cell line services for FZD1
     inducible overexpressing cell line services for FZD1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      FZD1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4