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FZD1 Gene

protein-coding   GIFtS: 70
GCID: GC07P090893

Frizzled Class Receptor 1

(Previous names: frizzled (Drosophila) homolog 1, frizzled homolog 1 (Drosophila),...)
  See FZD1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Frizzled Class Receptor 11 2     Frizzled Homolog 1 (Drosophila)1
Frizzled 1, Seven Transmembrane Spanning Receptor1 2     Homolog Of1
Frizzled Family Receptor 11 2     Frizzled Homolog 12
Wnt Receptor1 2     Frizzled, Drosophila, Homolog Of, 12
hFz12 3     frizzled-12
11     fz-12
Drosophila1     fzE12
frizzled1     Fz-13
Frizzled (Drosophila) Homolog 11     FzE13

External Ids:    HGNC: 40381   Entrez Gene: 83212   Ensembl: ENSG000001572407   OMIM: 6034085   UniProtKB: Q9UP383   

Export aliases for FZD1 gene to outside databases

Previous GC identifers: GC07P089429 GC07P090491 GC07P090505 GC07P090538 GC07P090731 GC07P085501


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FZD1 Gene:
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling
proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular
region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in
various tissues. (provided by RefSeq, Jul 2008)

GeneCards Summary for FZD1 Gene:
FZD1 (frizzled class receptor 1) is a protein-coding gene. Diseases associated with FZD1 include exudative vitreoretinopathy. GO annotations related to this gene include PDZ domain binding and G-protein coupled receptor activity. An important paralog of this gene is FZD3.

UniProtKB/Swiss-Prot: FZD1_HUMAN, Q9UP38
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical
signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear
accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and
calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway
or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of
GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and
intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B

Gene Wiki entry for FZD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the FZD1 gene promoter:
         Pax-5   AML1a   NRSF form 1   HSF1 (long)   Nkx2-5   NRSF form 2   C/EBPalpha   Egr-2   HSF1short   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFZD1 promoter sequence
   Search Chromatin IP Primers for FZD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FZD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21   Ensembl cytogenetic band:  7q21.13   HGNC cytogenetic band: 7q21

FZD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FZD1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P090893:  view genomic region     (about GC identifiers)

Start:
90,893,783 bp from pter      End:
90,898,132 bp from pter
Size:
4,350 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 90,224,254-90,228,603     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FZD1_HUMAN, Q9UP38 (See protein sequence)
Recommended Name: Frizzled-1 precursor  
Size: 647 amino acids; 71158 Da
Secondary accessions: A4D1E8 O94815 Q549T8

Explore the universe of human proteins at neXtProt for FZD1: NX_Q9UP38

Explore proteomics data for FZD1 at MOPED

Post-translational modifications: 

  • Ubiquitinated by ZNRF3, leading to its degradation by the proteasome (By similarity)1
  • Glycosylation2 at Asn130, Asn231
  • Modification sites at PhosphoSitePlus

  • See FZD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003496.1  
    ENSEMBL proteins: 
     ENSP00000287934  
    Reactome Protein details: Q9UP38

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FZD: GPCR / Class F : Frizzled receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: FZD1
    Frizzled Class GPCRs

    5 InterPro protein domains:
     IPR000539 Frizzled
     IPR020067 Frizzled_dom
     IPR026548 FZD1
     IPR015526 Frizzled/SFRP
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry Q9UP38

    ProtoNet protein and cluster: Q9UP38

    1 Blocks protein domain: IPB000539 Frizzled protein signature

    UniProtKB/Swiss-Prot: FZD1_HUMAN, Q9UP38
    Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in
    the activation of the Wnt/beta-catenin signaling pathway (By similarity)
    Domain: The FZ domain is involved in binding with Wnt ligands (By similarity)
    Similarity: Belongs to the G-protein coupled receptor Fz/Smo family
    Similarity: Contains 1 FZ (frizzled) domain


    Find genes that share domains with FZD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FZD1_HUMAN, Q9UP38
    Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical
    signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear
    accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and
    calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway
    or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of
    GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and
    intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
    Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B

         Genatlas biochemistry entry for FZD1:
    Drosophila frizzled polarity gene homolog,G protein coupled receptor superfamily,exhibiting characteristics of a
    WNT receptor,expressed in heart,brain,placenta,lung,kidney,pancreas,prostate and ovary

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005102receptor binding IPI14739301
    GO:0005109frizzled binding IPI19188438
    GO:0005515protein binding IPI19277043
         
    Find genes that share ontologies with FZD1           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for FZD1:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella-containin  Decreased substrate adherent c 

         14 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Fzd1):
     cardiovascular system  craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     hearing/vestibular/ear  homeostasis/metabolism  integument  nervous system  normal 
     other  pigmentation  reproductive system  skeleton 

    Find genes that share phenotypes with FZD1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fzd1tm1.1Boer for FZD1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FZD1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FZD1

    miRNA
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    miRTarBase miRNAs that target FZD1:
    hsa-mir-192-5p (MIRT026323), hsa-mir-335-5p (MIRT017459), hsa-mir-204-5p (MIRT005827), hsa-mir-215-5p (MIRT024292)

    Block miRNA regulation of human, mouse, rat FZD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FZD1 (see all 38):
    hsa-miR-26a-2* hsa-miR-146a hsa-let-7a-2* hsa-miR-1273d hsa-miR-3163 hsa-miR-3606 hsa-miR-425 hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidFZD1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FZD1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: FZD1 (NM_003505)
    Sino Biological Human cDNA Clone for FZD1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FZD1

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    eBioscience FlowRNA Probe Sets ( VA1-12197) for FZD1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FZD1_HUMAN, Q9UP38: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface IDA19643732
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with FZD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FZD1 About   (see all 28)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    3beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Signaling by Wnt0.79
    4CDK-mediated phosphorylation and removal of Cdc6
    Asymmetric localization of PCP proteins0.75
    PCP/CE pathway0.70
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    GSK3 Signaling0.61


    Find genes that share SuperPaths with FZD1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for FZD1
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FZD1 (see all 11)
        Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Colorectal Cancer Metastasis
    Glioblastoma Multiforme

    1 Tocris Bioscience Pathway for FZD1
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for FZD1
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    Selected BioSystems Pathways for FZD1 (see all 7)
        MicroRNAs in cardiomyocyte hypertrophy
    Wnt Signaling Pathway
    Adipogenesis
    Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway NetPath

    2 Sino Biological Pathways for FZD1
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    4 Reactome Pathways for FZD1
        disassembly of the destruction complex and recruitment of AXIN to the membrane
    PCP/CE pathway
    TCF dependent signaling in response to WNT
    Class B/2 (Secretin family receptors)


    Selected Kegg Pathways  (Kegg details for FZD1) (see all 7):
        Wnt signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection
    Pathways in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FZD1 (see all 6): 
              G Protein Coupled Receptors 384HT in human mouse rat
              Primary Cilia in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat
              Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FZD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FZD1 (Q9UP383 ENSP000002879344) via UniProtKB, MINT, STRING, and/or I2D (see all 97)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WNT4P567053, ENSP000002901674I2D: score=2 STRING: ENSP00000290167
    DCHS1Q96JQ03, ENSP000002994414I2D: score=1 STRING: ENSP00000299441
    DLG1Q129593, ENSP000003457314I2D: score=1 STRING: ENSP00000345731
    FAT4Q6V0I73, ENSP000003778624I2D: score=1 STRING: ENSP00000377862
    GNAO1P094713, ENSP000002624934I2D: score=1 STRING: ENSP00000262493
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation IEA--
    GO:0001944vasculature development IBA--
    GO:0003149membranous septum morphogenesis IEA--
    GO:0003150muscular septum morphogenesis IEA--
    GO:0003151outflow tract morphogenesis IEA--

    Find genes that share ontologies with FZD1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FZD1

    1 HMDB Compound for FZD1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FZD1 gene: 
    NM_003505.1  

    Unigene Cluster for FZD1:

    Frizzled family receptor 1
    Hs.94234  [show with all ESTs]
    Unigene Representative Sequence: AB017363
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000287934(uc003ula.3)
    miRNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FZD1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for FZD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FZD1
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      QuantiFast Probe-based Assays in human, mouse, rat FZD1
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12197) for FZD1 

    Additional mRNA sequence: 

    AB017363.1 AF072872.1 AK314996.1 AL049994.1 BC017719.2 BC051271.1 

    4 DOTS entries:

    DT.453919  DT.92422830  DT.100657816  DT.92422832 

    Selected AceView cDNA sequences (see all 63):

    BM756600 BU176762 BQ956211 BG289570 AA664127 CD518856 AI084462 CR597493 
    NM_003505 CA489698 AB017363 BU176007 AA158995 AI142814 BM738034 AF072872 
    BC051271 AI935436 CF455406 BM756060 BP338536 CF456097 BU627733 BX433281 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FZD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAAAGGGAA
    FZD1 Expression
    About this image


    FZD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             Midbrain dopaminergic-like neurons
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     Neural Crest (Gastrulation Derivatives)
             PureStem MEL2, NCr-fac Progenitor
     
     Thymus (Hematopoietic System)
             Thymus
    FZD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FZD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.94234

    UniProtKB/Swiss-Prot: FZD1_HUMAN, Q9UP38
    Tissue specificity: Expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal
    lung and kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FZD1 (see all 6): 
              G Protein Coupled Receptors 384HT in human mouse rat
              Primary Cilia in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat
              Stem Cells in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for FZD1
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FZD1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fzd11 , 5 frizzled homolog 1 (Drosophila)1, 5 88.32(n)1
    92.99(a)1
      5 (2.61 cM)5
    143621  NM_021457.31  NP_067432.21 
     47538735 
    chicken
    (Gallus gallus)
    Aves FZD11 frizzled family receptor 1 85.3(n)
    92.87(a)
      374062  NM_001030337.1  NP_001025508.1 
    lizard
    (Anolis carolinensis)
    Reptilia FZD16
    frizzled family receptor 1
    89(a)
    1 ↔ 1
    6(20755209-20757079)
    zebrafish
    (Danio rerio)
    Actinopterygii fzd7a1 frizzled homolog 7a 74.84(n)
    82.13(a)
      30369  NM_131139.1  NP_571214.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fz1 , 3 determination of sensory organ
    precursor cell more3
    frizzled1
    48(a)3
    58.37(n)1
    52.75(a)1
      453071  NM_080073.31  NP_524812.11 


    ENSEMBL Gene Tree for FZD1 (if available)
    TreeFam Gene Tree for FZD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FZD1 gene
    FZD32  FZD102  FZD82  FZD52  FZD22  FZD92  SFRP42  SMO2  
    FZD42  FZD62  SFRP12  FRZB2  SFRP52  FZD72  SFRP22  
    10 SIMAP similar genes for FZD1 using alignment to 1 protein entry:     FZD1_HUMAN:
    FZD7    FZD2    GPCR    FZD6    FZD10    FZD3
    FZD5    FZD9    FZD4    FZD8

    Find genes that share paralogs with FZD1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FZD1 (see all 139)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs106543961,2
    C--90891788(+) CAATC-/AG/GA 
            
    AAATA
    1 -- us2k11NA 2
    rs566653111,2
    C--90891789(+) AATCA-/AG/GA 
            
    AATAC
    1 -- us2k10--------
    rs1912848381,2
    --90891808(+) AAAAAG/TGCATT 1 -- us2k10--------
    rs1834804671,2
    --90891936(+) AACATC/GCTGGG 1 -- us2k10--------
    rs1898992041,2
    --90892146(+) CAAACA/GTTTTA 1 -- us2k10--------
    rs1386712571,2
    C--90892166(+) AAAACC/TTTTTC 1 -- us2k10--------
    rs1811856981,2
    --90892293(+) CATTTC/GATCTG 1 -- us2k10--------
    rs795310801,2
    C--90892391(+) CCTCTC/GTAAGG 1 -- us2k10--------
    rs113490251,2
    C--90892547(+) CAGGC-/AAAAAA 1 -- us2k1 trp30--------
    rs1494928911,2
    C--90892574(+) AATTA-/ATAGTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FZD1 (90893783 - 90898132 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FZD1: --
    Human Gene Mutation Database (HGMD): FZD1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FZD1
    DNA2.0 Custom Variant and Variant Library Synthesis for FZD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603408    OMIM disorders: --

    1 disease for FZD1:    
    About MalaCards
    exudative vitreoretinopathy

    1 disease from the University of Copenhagen DISEASES database for FZD1:
    Exudative vitreoretinopathy

    Find genes that share disorders with FZD1           About GenesLikeMe

    Genetic Association Database (GAD): FZD1
    Human Genome Epidemiology (HuGE) Navigator: FZD1 (6 documents)

    Export disorders for FZD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FZD1 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with FZD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7. (PubMed id 9813155)1, 2, 3, 9 Sagara N.... Katoh M. (Biochem. Biophys. Res. Commun. 1998)
    2. Functional and association analysis of frizzled 1 (FZD1) promoter haplotypes with femoral neck geometry. (PubMed id 20051274)1, 4, 9 Zhang Y....Zmuda J.M. (Bone 2010)
    3. Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. (PubMed id 10557084)1, 2, 9 Gazit A....Aaronson S.A. (Oncogene 1999)
    4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    5. Functional characterization of genetic variation in the Frizzled 1 (FZD1) promoter and association with bone phenotypes: more to the LRP5 story? (PubMed id 18715140)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    6. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    7. Non-association between polymorphisms of the frizzled receptor genes and bone mineral density in postmenopausal Korean women. (PubMed id 19543507)1, 4 Kim J.G....Moon S.Y. (J. Korean Med. Sci. 2009)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    10. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8321 HGNC: 4038 AceView: FZD1 Ensembl:ENSG00000157240 euGenes: HUgn8321
    ECgene: FZD1 Kegg: 8321 H-InvDB: FZD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FZD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FZD1 gene:
    Search GeneIP for patents involving FZD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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