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Aliases for FYTTD1 Gene

Aliases for FYTTD1 Gene

  • Forty-Two-Three Domain Containing 1 2 3
  • Forty-Two-Three Domain-Containing Protein 1 3 4
  • UAP56-Interacting Factor 2 3
  • Protein 40-2-3 3 4
  • UIF 3 4

External Ids for FYTTD1 Gene

Summaries for FYTTD1 Gene

GeneCards Summary for FYTTD1 Gene

FYTTD1 (Forty-Two-Three Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include mRNA binding.

UniProtKB/Swiss-Prot for FYTTD1 Gene

  • Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FYTTD1 Gene

Genomics for FYTTD1 Gene

Genomic Location for FYTTD1 Gene

Start:
197,737,179 bp from pter
End:
197,787,596 bp from pter
Size:
50,418 bases
Orientation:
Plus strand

Genomic View for FYTTD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FYTTD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FYTTD1 Gene

Regulatory Elements for FYTTD1 Gene

Proteins for FYTTD1 Gene

  • Protein details for FYTTD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QD9-UIF_HUMAN
    Recommended name:
    UAP56-interacting factor
    Protein Accession:
    Q96QD9
    Secondary Accessions:
    • A8MY74
    • B2RCB2
    • B7Z3R4
    • B7Z7V1
    • B7Z8I0
    • B7ZAJ3
    • C9J7P6
    • C9JNG6
    • C9JTH3
    • C9JY50
    • Q96SL9
    • Q9BQI8

    Protein attributes for FYTTD1 Gene

    Size:
    318 amino acids
    Molecular mass:
    35818 Da
    Quaternary structure:
    • Interacts with CHTOP (By similarity). Interacts with DDX39B/UAP56 and NXF1; interaction with DDX39B/UAP56 and NXF1 are mutually exclusive. Interacts with SSRP1; required for its recruitment to mRNAs.

    Alternative splice isoforms for FYTTD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FYTTD1 Gene

Proteomics data for FYTTD1 Gene at MOPED

Post-translational modifications for FYTTD1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys215 and Lys261

No data available for DME Specific Peptides for FYTTD1 Gene

Domains for FYTTD1 Gene

Protein Domains for FYTTD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FYTTD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96QD9

UniProtKB/Swiss-Prot:

UIF_HUMAN
Family:
  • Belongs to the UIF family.:
    • Q96QD9
genes like me logo Genes that share domains with FYTTD1: view

No data available for Gene Families for FYTTD1 Gene

Function for FYTTD1 Gene

Molecular function for FYTTD1 Gene

UniProtKB/Swiss-Prot Function: Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4.

Gene Ontology (GO) - Molecular Function for FYTTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IDA 19836239
GO:0005515 protein binding IPI 19836239
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with FYTTD1: view

Phenotypes for FYTTD1 Gene

genes like me logo Genes that share phenotypes with FYTTD1: view

miRNA for FYTTD1 Gene

miRTarBase miRNAs that target FYTTD1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FYTTD1 Gene

Localization for FYTTD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FYTTD1 Gene

Nucleus, nucleoplasm. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FYTTD1 Gene COMPARTMENTS Subcellular localization image for FYTTD1 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for FYTTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0016607 nuclear speck IDA 19836239
genes like me logo Genes that share ontologies with FYTTD1: view

Pathways for FYTTD1 Gene

SuperPathways for FYTTD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FYTTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006406 mRNA export from nucleus IMP 19836239
genes like me logo Genes that share ontologies with FYTTD1: view

No data available for Pathways by source for FYTTD1 Gene

Transcripts for FYTTD1 Gene

Unigene Clusters for FYTTD1 Gene

Forty-two-three domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FYTTD1 Gene

No ASD Table

Relevant External Links for FYTTD1 Gene

GeneLoc Exon Structure for
FYTTD1
ECgene alternative splicing isoforms for
FYTTD1

Expression for FYTTD1 Gene

mRNA expression in normal human tissues for FYTTD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FYTTD1 Gene

SOURCE GeneReport for Unigene cluster for FYTTD1 Gene Hs.277533

genes like me logo Genes that share expressions with FYTTD1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FYTTD1 Gene

Orthologs for FYTTD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FYTTD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FYTTD1 35
  • 99.44 (n)
  • 100 (a)
FYTTD1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FYTTD1 35
  • 87.7 (n)
  • 88.14 (a)
FYTTD1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 95 (a)
OneToMany
FYTTD1 36
  • 94 (a)
OneToMany
LOC609238 35
  • 92.22 (n)
  • 94.64 (a)
mouse
(Mus musculus)
Mammalia Fyttd1 35
  • 88.22 (n)
  • 92.74 (a)
Fyttd1 16
Fyttd1 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FYTTD1 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FYTTD1 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fyttd1 35
  • 86.53 (n)
  • 91.78 (a)
chicken
(Gallus gallus)
Aves FYTTD1 35
  • 70.04 (n)
  • 64.38 (a)
FYTTD1 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FYTTD1 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fyttd1 35
  • 56.99 (n)
  • 52.1 (a)
Species with no ortholog for FYTTD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FYTTD1 Gene

ENSEMBL:
Gene Tree for FYTTD1 (if available)
TreeFam:
Gene Tree for FYTTD1 (if available)

Paralogs for FYTTD1 Gene

Pseudogenes.org Pseudogenes for FYTTD1 Gene

genes like me logo Genes that share paralogs with FYTTD1: view

No data available for Paralogs for FYTTD1 Gene

Variants for FYTTD1 Gene

Sequence variations from dbSNP and Humsavar for FYTTD1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs534030 -- 197,767,074(-) AAAGG(G/T)GGTAA intron-variant
rs594895 -- 197,776,384(-) AAAAA(A/C)AAATT intron-variant
rs602446 -- 197,770,630(+) AGCCT(C/T)GGCCT intron-variant
rs654260 -- 197,772,862(+) CCTCA(A/G)CCTCC intron-variant
rs1273557 -- 197,782,227(-) AATAC(C/T)GCTAT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for FYTTD1 Gene

Variant ID Type Subtype PubMed ID
dgv1558e1 CNV Complex 17122850
dgv1560e1 CNV Complex 17122850
nsv428433 CNV Gain+Loss 18775914
nsv878204 CNV Gain 21882294
dgv1561e1 CNV Complex 17122850
nsv829831 CNV Loss 17160897
nsv878205 CNV Loss 21882294
nsv829832 CNV Loss 17160897
esv2751989 CNV Gain 17911159
esv24396 CNV Loss 19812545
dgv5378n71 CNV Gain 21882294
nsv878208 CNV Gain 21882294

Relevant External Links for FYTTD1 Gene

HapMap Linkage Disequilibrium report
FYTTD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FYTTD1 Gene

Disorders for FYTTD1 Gene

Relevant External Links for FYTTD1

Human Genome Epidemiology (HuGE) Navigator
FYTTD1
genes like me logo Genes that share disorders with FYTTD1: view

No data available for UniProtKB/Swiss-Prot for FYTTD1 Gene

Publications for FYTTD1 Gene

  1. UIF, a new mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA. (PMID: 19836239) Hautbergue G.M. … Wilson S.A. (Curr. Biol. 2009) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  5. Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. (PMID: 15862967) Pope S.N. … Lee I.R. (J. Steroid Biochem. Mol. Biol. 2005) 3

Products for FYTTD1 Gene

Sources for FYTTD1 Gene

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