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Aliases for FYTTD1 Gene

Aliases for FYTTD1 Gene

  • Forty-Two-Three Domain Containing 1 2 3 5
  • Forty-Two-Three Domain-Containing Protein 1 3 4
  • UAP56-Interacting Factor 2 3
  • Protein 40-2-3 3 4
  • UIF 3 4

External Ids for FYTTD1 Gene

Previous GeneCards Identifiers for FYTTD1 Gene

  • GC03P198965
  • GC03P197464
  • GC03P194779

Summaries for FYTTD1 Gene

GeneCards Summary for FYTTD1 Gene

FYTTD1 (Forty-Two-Three Domain Containing 1) is a Protein Coding gene. Among its related pathways are Transport of Mature Transcript to Cytoplasm and RNA Polymerase II Transcription Termination. GO annotations related to this gene include poly(A) RNA binding and mRNA binding.

UniProtKB/Swiss-Prot for FYTTD1 Gene

  • Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FYTTD1 Gene

Genomics for FYTTD1 Gene

Regulatory Elements for FYTTD1 Gene

Enhancers for FYTTD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F197807 0.9 Ensembl ENCODE 10.7 +72.8 72809 4.9 ZNF362 RNF2 HLF ZNF384 CEBPG ATF2 ZFP69B ZNF324 ZFHX2 ATF3 ENSG00000234136 MIR922 RUBCN FYTTD1 LRCH3
GH03F197820 0.9 ENCODE 10.5 +83.9 83852 1.6 ATF1 MLX ARID4B DMAP1 ZSCAN9 RAD21 ZNF48 RARA YY1 MIXL1 LRCH3 RUBCN MIR922 FYTTD1 LOC220729 ENSG00000234136
GH03F197879 0.9 ENCODE 10.5 +143.4 143428 1.2 ELF3 MLX RARA GATA4 ZNF366 CREM MIXL1 HMG20B SP5 CEBPB MIR922 RUBCN FYTTD1 IQCG SEPT14P3 GC03P197886 LOC105374310
GH03F197701 0.8 ENCODE 11.5 -35.1 -35148 1.6 IRF2 KLF1 ZNF2 ZNF335 ZNF366 FOXK2 SCRT2 KLF7 ZNF600 ZSCAN29 LOC220729 MIR922 FYTTD1 RUBCN PIR54031
GH03F197674 0.5 ENCODE 15.9 -62.1 -62051 1.5 SCRT1 SCRT2 ATF2 FYTTD1 LOC220729 RUBCN MIR922 GC03P197672 GC03P197699
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FYTTD1 on UCSC Golden Path with GeneCards custom track

Promoters for FYTTD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001384208 -379 2001 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for FYTTD1 Gene

Chromosome:
3
Start:
197,737,179 bp from pter
End:
197,787,596 bp from pter
Size:
50,418 bases
Orientation:
Plus strand

Genomic View for FYTTD1 Gene

Genes around FYTTD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FYTTD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FYTTD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FYTTD1 Gene

Proteins for FYTTD1 Gene

  • Protein details for FYTTD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QD9-UIF_HUMAN
    Recommended name:
    UAP56-interacting factor
    Protein Accession:
    Q96QD9
    Secondary Accessions:
    • A8MY74
    • B2RCB2
    • B7Z3R4
    • B7Z7V1
    • B7Z8I0
    • B7ZAJ3
    • C9J7P6
    • C9JNG6
    • C9JTH3
    • C9JY50
    • Q96SL9
    • Q9BQI8

    Protein attributes for FYTTD1 Gene

    Size:
    318 amino acids
    Molecular mass:
    35818 Da
    Quaternary structure:
    • Interacts with CHTOP (By similarity). Interacts with DDX39B/UAP56 and NXF1; interaction with DDX39B/UAP56 and NXF1 are mutually exclusive. Interacts with SSRP1; required for its recruitment to mRNAs.

    Alternative splice isoforms for FYTTD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FYTTD1 Gene

Post-translational modifications for FYTTD1 Gene

  • Ubiquitination at Lys 215 and Lys 261
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FYTTD1 Gene

Domains & Families for FYTTD1 Gene

Protein Domains for FYTTD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FYTTD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96QD9

UniProtKB/Swiss-Prot:

UIF_HUMAN :
  • Belongs to the UIF family.
Family:
  • Belongs to the UIF family.
genes like me logo Genes that share domains with FYTTD1: view

No data available for Gene Families for FYTTD1 Gene

Function for FYTTD1 Gene

Molecular function for FYTTD1 Gene

UniProtKB/Swiss-Prot Function:
Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4.

Gene Ontology (GO) - Molecular Function for FYTTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IDA 19836239
GO:0005515 protein binding IPI 19836239
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with FYTTD1: view
genes like me logo Genes that share phenotypes with FYTTD1: view

Animal Model Products

miRNA for FYTTD1 Gene

miRTarBase miRNAs that target FYTTD1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FYTTD1 Gene

Localization for FYTTD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FYTTD1 Gene

Nucleus, nucleoplasm. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FYTTD1 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for FYTTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IEA,IDA 19836239
GO:0016607 nuclear speck IEA,IDA 19836239
genes like me logo Genes that share ontologies with FYTTD1: view

Pathways & Interactions for FYTTD1 Gene

genes like me logo Genes that share pathways with FYTTD1: view

Gene Ontology (GO) - Biological Process for FYTTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006406 mRNA export from nucleus IMP 19836239
GO:0006810 transport IEA --
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with FYTTD1: view

No data available for SIGNOR curated interactions for FYTTD1 Gene

Transcripts for FYTTD1 Gene

Unigene Clusters for FYTTD1 Gene

Forty-two-three domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FYTTD1 Gene

No ASD Table

Relevant External Links for FYTTD1 Gene

GeneLoc Exon Structure for
FYTTD1
ECgene alternative splicing isoforms for
FYTTD1

Expression for FYTTD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FYTTD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FYTTD1 Gene

This gene is overexpressed in Testis (18.3) and CD8 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FYTTD1 Gene



Protein tissue co-expression partners for FYTTD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FYTTD1 Gene:

FYTTD1

SOURCE GeneReport for Unigene cluster for FYTTD1 Gene:

Hs.277533

mRNA Expression by UniProt/SwissProt for FYTTD1 Gene:

Q96QD9-UIF_HUMAN
Tissue specificity: Expressed in a wide variety of cancer types.
genes like me logo Genes that share expression patterns with FYTTD1: view

No data available for mRNA differential expression in normal tissues for FYTTD1 Gene

Orthologs for FYTTD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FYTTD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FYTTD1 34 35
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 95 (a)
OneToMany
FYTTD1 35
  • 94 (a)
OneToMany
LOC609238 34
  • 92.22 (n)
mouse
(Mus musculus)
Mammalia Fyttd1 34 16 35
  • 88.22 (n)
cow
(Bos Taurus)
Mammalia FYTTD1 34 35
  • 87.7 (n)
rat
(Rattus norvegicus)
Mammalia Fyttd1 34
  • 86.53 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FYTTD1 35
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FYTTD1 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves FYTTD1 34 35
  • 70.04 (n)
lizard
(Anolis carolinensis)
Reptilia FYTTD1 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fyttd1 34
  • 56.99 (n)
Species where no ortholog for FYTTD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FYTTD1 Gene

ENSEMBL:
Gene Tree for FYTTD1 (if available)
TreeFam:
Gene Tree for FYTTD1 (if available)

Paralogs for FYTTD1 Gene

Pseudogenes.org Pseudogenes for FYTTD1 Gene

genes like me logo Genes that share paralogs with FYTTD1: view

No data available for Paralogs for FYTTD1 Gene

Variants for FYTTD1 Gene

Sequence variations from dbSNP and Humsavar for FYTTD1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10470713 -- 197,749,577(+) AAGTA(C/T)AGGGG upstream-variant-2KB, utr-variant-5-prime
rs10554264 -- 197,755,612(+) GGCTA(-/ATTT)ATTTA intron-variant
rs111226542 -- 197,776,628(+) GAATA(C/G)AAAGC intron-variant
rs111231913 -- 197,766,457(+) TGTGT(G/T)TGTTT intron-variant
rs111249993 -- 197,771,644(+) TGGTG(A/G)CGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FYTTD1 Gene

Variant ID Type Subtype PubMed ID
nsv829832 CNV loss 17160897
nsv829831 CNV loss 17160897
nsv593158 CNV loss 21841781
nsv428433 CNV gain+loss 18775914
nsv1161021 CNV duplication 26073780
nsv1136802 CNV deletion 24896259
nsv1132580 CNV duplication 24896259
nsv1115653 CNV duplication 24896259
nsv1077956 CNV duplication 25765185
nsv1011831 CNV gain 25217958
esv3599322 CNV gain 21293372
esv3599319 CNV gain 21293372
esv3569234 CNV loss 25503493
esv2763718 CNV gain+loss 21179565
esv2759214 CNV gain+loss 17122850
esv2751989 CNV gain 17911159
esv24396 CNV loss 19812545
dgv8864n54 CNV loss 21841781

Variation tolerance for FYTTD1 Gene

Residual Variation Intolerance Score: 31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FYTTD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FYTTD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FYTTD1 Gene

Disorders for FYTTD1 Gene

Relevant External Links for FYTTD1

Human Genome Epidemiology (HuGE) Navigator
FYTTD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FYTTD1

No disorders were found for FYTTD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FYTTD1 Gene

Publications for FYTTD1 Gene

  1. UIF, a new mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA. (PMID: 19836239) Hautbergue G.M. … Wilson S.A. (Curr. Biol. 2009) 2 3 4 64
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. Luzp4 defines a new mRNA export pathway in cancer cells. (PMID: 25662211) Viphakone N. … Wilson S.A. (Nucleic Acids Res. 2015) 4 64

Products for FYTTD1 Gene

Sources for FYTTD1 Gene

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