FYN Gene
protein-coding GIFtS: 73
GCID: GC06M111981
|
|
FYN oncogene related to SRC, FGR, YES
| |
Aliases
for FYN gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FYN Oncogene Related To SRC, FGR, YES1 2 | | C-Syn Protooncogene2 | | SLK1 2 3 | | OKT3-Induced Calcium Influx Regulator2 | | SYN1 2 | | P59-FYN1 | | Proto-Oncogene C-Fyn2 3 | | Src/Yes-Related Novel2 | | Proto-Oncogene Syn2 3 | | Tyrosine Kinase P59fyn(T)2 | | Src-Like Kinase2 3 | | Tyrosine-Protein Kinase Fyn2 | | EC 2.7.10.23 8 | | P59-Fyn1 | | MGC453501 | | EC 2.7.108 |
Export aliases for FYN gene to outside databasesPrevious GC identifers: GC06M111817 GC06M112005 GC06M112028 GC06M112089 GC06M109555 |
Summaries
for FYN gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FYN:
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinasethat has been implicated in the control of cell growth. The protein associates with the p85 subunit ofphosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variantsencoding distinct isoforms exist. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: FYN_HUMAN, P06241Function: Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation ofcell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immuneresponse and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain.Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation,activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility throughphosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling byphosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 andMAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates insignal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of theglomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL andTRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within thecentral nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA,a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiationand proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation ofTCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment ofCSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1
 summary
for FYN: Src kinases consist of eight non-receptor tyrosine kinases (Src, Fyn, Yes, Lck, Lyn, Hck, Fgr and Blk) that
interact with the intracellular domains of growth factor/cytokine receptors, GPCRs and integrins. Members of
the Src kinase family have a very similar domain structure with a high degree of homology in the SH1
(catalytic), linker, SH2 (p-Tyr binding), SH3 (protein-protein interaction) and SH4 (membrane association)
domains. c-Src, Fyn and Yes are ubiquitously expressed, although high levels of c-Src are found in
platelets, neural tissue and osteoclasts. For c-Src, autophosphorylation of Tyr418 and dephosphorylation of
Tyr530 is required to switch the kinase from the inactive closed formation to the active open formation.
c-Src can be inactivated by two kinases, c-Src kinase (CSK) and CSK homologous kinase (CHK), both of which
phosphorylate Tyr530 of c-Src. The activity of the Src kinase family can also be regulated by phosphatases
(e.g. SHP1), binding to adaptor proteins (e.g. Cbp) and proteasomal degradation. Src kinases are key
upstream mediators of both the PI 3-K and MAPK signaling pathways, and have been shown to have important
roles in cell proliferation, migration and survival.
Gene Wiki entry for FYN
|
Genomic Views
for FYN gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FYN gene promoter:
AP-1 ATF-2 STAT5A c-Jun ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for FYN
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FYN |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q21 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q21FYN Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M111981: view genomic region
(about GC identifiers)
Start:
|
111,981,535 bp from pter |
End:
|
112,194,655 bp from pter |
Size:
|
213,121 bases |
Orientation:
|
minus strand |
|
Proteins
for FYN gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FYN_HUMAN, P06241 (See
protein sequence)Recommended Name: Tyrosine-protein kinase Fyn Size: 537 amino acids; 60762 Da
Cofactor: Manganese
Subunit: Interacts (via its SH3 domain) with PIK3R1 and PRMT8. Interacts with FYB, PAG1, and SH2D1A. Interacts withCD79A (tyrosine-phosphorylated form); the interaction increases FYN activity. Interacts (via SH2 domain) with CSF1R(tyrosine phosphorylated) (By similarity). Interacts with TOM1L1 (phosphorylated form). Interacts with KDR (tyrosinephosphorylated) (By similarity). Interacts with SH2D1A and SLAMF1. Interacts (via its SH3 domain) with HEV ORF3protein. Interacts with ITCH; the interaction phosphorylates ITCH and negatively regulates its activity. Interactswith FASLG. Interacts with RUNX3. Interacts with KIT. Interacts with EPHA8; possible downstream effector of EPHA8 inregulation of cell adhesion. Interacts with PTK2/FAK1; this interaction leads to PTK2/FAK1 phosphorylation andactivation. Interacts with CAV1; this interaction couples integrins to the Ras-ERK pathway
Subcellular location: Cytoplasm. Nucleus. Cell membrane. Note=Present and active in lipid rafts. Palmitoylation iscrucial for proper trafficking
6/20 PDB 3D structures from  and Proteopedia  for FYN (see all 20):1A0N (3D)
1AOT (3D)
1AOU (3D)
1AVZ (3D)
1AZG (3D)
1EFN (3D)
Secondary accessions: B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7Alternative splicing: 3 isoforms: P06241-1 P06241-2 P06241-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FYN: NX_P06241
Post-translational modifications:
Autophosphorylated at Tyr-420. Phosphorylation on the C-terminal tail at Tyr-531 by CSK maintains the enzyme in aninactive state (By similarity). PTPRC/CD45 dephosphorylates Tyr-531 leading to activation. ultraviolet B (UVB)strongly increase phosphorylation at Thr-12 and kinase activity, and promotes translocation from the cytoplasm to thenucleus1
Palmitoylation at Cys-3 and Cys-6 regulates subcellular location (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P06241
4/41 DME Specific Peptides for FYN (P06241) (see all 41)
FYN Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_002028.1 NP_694592.1 NP_694593.1
ENSEMBL proteins: ENSP00000357671 ENSP00000346671 ENSP00000229471 ENSP00000357656 ENSP00000357667 ENSP00000427993 ENSP00000429294 ENSP00000429866 ENSP00000428695 ENSP00000430364 ENSP00000428493 ENSP00000429992 ENSP00000429590 ENSP00000429813 ENSP00000428045 ENSP00000428983 ENSP00000428042 ENSP00000430455 ENSP00000229470 ENSP00000348295 ENSP00000440646 ENSP00000445439 Reactome Protein details: P06241
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
FYN for ontologies About GeneDecksing
FYN Antibody Products:
Assay Products for FYN: |
Protein
Domains /
Families
for FYN gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FYN for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry P06241ProtoNet protein and cluster: P06241 3 Blocks protein families: IPB000980 SH2 domain signature IPB001452 SH3 domain signature IPB008266 Tyrosine protein kinase
UniProtKB/Swiss-Prot: FYN_HUMAN, P06241Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamilySimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 SH2 domainSimilarity: Contains 1 SH3 domain |
Function
for FYN gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FYN_HUMAN, P06241Function: Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation ofcell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immuneresponse and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain.Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation,activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility throughphosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling byphosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 andMAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates insignal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of theglomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL andTRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within thecentral nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA,a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiationand proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation ofTCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment ofCSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphateEnzyme regulation: Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated bydephosphorylation of this site Genatlas biochemistry entry for FYN:SRC/YES-related oncogene homolog,involved in T cell signaling regulation,STAR (signal transduction and activator ofRNA) family
Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FYN (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FYN (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): FYN (NM_153047) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FYN | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FYN |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FYN |
Gene Ontology (GO): 5/17 molecular function terms (GO ID links to tree view) (see all 17): About this table
FYN for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for FYN:
Animal Models:
Mouse knock-outs for FYN: Fyntm1Sor Fyntm1Rmp Fyntm1Fam
15 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Fyn):
FYN for phenotypes About GeneDecksing
|
Pathways & Interactions
for FYN gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/106 super-pathways (see all 106) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by FGFR | | | 2 | PIP3 activates AKT signaling | | | 3 | CD28 co-stimulation | | | 4 | Development_Prolactin receptor signaling | | | 5 | Phosphorylation of GAB2 by SFKs | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/15 EMD Millipore Pathways for FYN (see all 15)
5/26 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FYN (see all 26)
2 
Cell Signaling Technology (CST) Pathways for FYN
5/16  GeneGo (Thomson Reuters) Pathways for FYN (see all 16)
5/39  BioSystems Pathways for FYN (see all 39)
5/70 
Reactome Pathways for FYN (see all 70)
5/12 
Kegg Pathways (Kegg details for FYN) (see all 12):
FYN for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FYN
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/579 Interacting proteins for FYN (P062411, 2, 3 ENSP000003576564) via UniProtKB, MINT, STRING, and/or I2D (see all 579)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| MED28 | Q9H2041, 2, 3, ENSP000002373804 | EBI-2561531,EBI-514199 MINT-7041679 I2D:
score=4 STRING: ENSP00000237380 | | ABL2 | P426841, 2, 3, ENSP000003565954 | EBI-2561531,EBI-1102694 MINT-8110899 I2D:
score=3 STRING: ENSP00000356595 | | CD2 | P067292, 3, ENSP000003584904 | MINT-50661 MINT-50664 MINT-50663 MINT-50665 I2D:
score=5 STRING: ENSP00000358490 | | WAS | P427682, 3, ENSP000003658914 | MINT-50146 MINT-50144 MINT-14847 MINT-50145 I2D:
score=4 STRING: ENSP00000365891 | | PAG1 | Q9NWQ82, 3, ENSP000002205974 | MINT-8032868 MINT-8034123 MINT-8034138 MINT-8032853 I2D:
score=3 STRING: ENSP00000220597 |
About this table
Gene Ontology (GO): 5/32 biological process terms (GO ID links to tree view) (see all 32): About this table
FYN for ontologies About GeneDecksing
|
Drugs & Compounds
for FYN gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
FYN for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for FYN |
Compounds for FYN available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| 1-Naphthyl PP1 | Src family kinase inhibitor; also inhibits c-Abl | [221243-82-9] |
4 HMDB Compounds for FYN About this table
2 DrugBank Compounds for FYN About this table
10/53 Novoseek chemical compound relationships for FYN gene (see all 53) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
89.5 |
600 |
9104812 (6), 1465444 (6), 9535867 (4), 10838156 (4) (see all 99) |
| phosphotyrosine |
73.1 |
13 |
7524477 (1), 12654250 (1), 1383216 (1), 11063873 (1) (see all 10) |
| herbimycin a |
67.6 |
3 |
9049148 (1), 7543423 (1), 10871840 (1) |
| phosphatidylinositol |
65.7 |
41 |
10848967 (5), 1465444 (3), 7642581 (2), 1328986 (1) (see all 30) |
| 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine |
54.1 |
1 |
18632659 (1) |
| happ |
45.2 |
14 |
15140940 (4), 16237174 (3) |
| threonine |
44.2 |
4 |
1699196 (1), 17098432 (1), 9155022 (1) |
| piceatannol |
40.4 |
2 |
10528214 (1), 11154209 (1) |
| serine |
38.7 |
9 |
12721299 (1), 17098432 (1), 8413237 (1), 8227079 (1) (see all 7) |
| calcium |
35.6 |
26 |
7621861 (3), 10964479 (2), 8500615 (2), 11776298 (1) (see all 19) |
Search CenterWatch for drugs/clinical trials and news about FYN
|
Transcripts
for FYN gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FYN gene (4 alternative transcripts): NM_002037.5 NM_153047.3 NM_153048.3 NM_001242779.1 Unigene Cluster for FYN: FYN oncogene related to SRC, FGR, YES Hs.390567 [show with all ESTs]Unigene Representative Sequence: BX53757118/32 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 32): ENST00000368682(uc003pvh.3 uc003pvi.3) ENST00000354650(uc003pvj.3 uc003pvk.3)
ENST00000229471(uc010kdy.1) ENST00000368667 ENST00000368678 ENST00000491885
ENST00000467921 ENST00000471959 ENST00000496864 ENST00000476769 ENST00000495935
ENST00000467899 ENST00000495927 ENST00000523322 ENST00000462856 ENST00000520518
ENST00000517419 ENST00000518295
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FYN (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FYN (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): FYN (NM_153047) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FYN | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FYN |
Additional cDNA sequence: AB451293.1 AB451426.1 AK056699.1 AY429536.1 BC032496.1 BX537571.1 M14333.1 M14676.1 S74774.1 20 DOTS entries: DT.86843886 DT.95289422 DT.121321013 DT.95132434 DT.75101275 DT.92435837 DT.121320911 DT.100880796 DT.121320948 DT.100880804 DT.100880805 DT.121320926 DT.121320982 DT.95264558 DT.100880803 DT.100880806 DT.436784 DT.75198251 DT.86800269 DT.95131340 24/304 AceView cDNA sequences (see all 304): NM_153047 AY429536 AA934796 AI150708 BQ224296 BM738560 AI687609 NM_153048 M14333 H88244 AL134258 AI498268 BI552534 BI468586 AU141939 AU185836 BF593649 BG429936 BE221421 BQ889903 AI650971 BM724842 CB161968 BC032496
GeneLoc Exon Structure
|
Expression
for FYN gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FYN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTAACAAA
About this image
See FYN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FYN
SOURCE GeneReport for Unigene cluster: Hs.390567
UniProtKB/Swiss-Prot: FYN_HUMAN, P06241Tissue specificity: Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoieticlineages, especially T-lymphocytes
SABiosciences Expression via Pathway-Focused PCR Arrays including FYN: | Oncogenes & Tumor Suppressor Genes in human mouse rat | | Adherens Junctions in human mouse rat | | Focal Adhesions in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FYN
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FYN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FYN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FYN | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FYN |
Orthologs
for FYN gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FYN gene from 6/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FYN1 |
FYN oncogene related to SRC, FGR, YES |
81.59(n)
92.88(a) |
|
396294 NM_205349.1 NP_990680.1 |
lizard
(Anolis carolinensis) |
Reptilia |
FYN6 |
-- |
99(a) |
1 ↔ 1 |
1(192361008-192397387) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BC043749.12 |
-- |
82.19(n) |
|
BC043749.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
fynb1 |
FYN oncogene related to SRC, FGR, YES b |
77.9(n)
91.81(a) |
|
574422 NM_001029969.1 NP_001025140.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Src64B3 |
ring canal formation protein tyrosine kinase |
53(a) |
|
64B12 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
src-11 , 3 |
Expression: vulva, anus, mu_bod, pharyngeal
muscle, more3
Protein SRC-11 |
48(a)
(best of 4)3
54.21(n)1
52.41(a)1 |
|
I(1567610-1580076)3
1717221 NM_058465.41 NP_490866.41 |
ENSEMBL Gene Tree for FYN (if available)
TreeFam Gene Tree for FYN (if available) |
Paralogs
for FYN gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FYN gene
- TEC2 FRK2 LCK2 BLK2 FGR2 ITK2 LYN2 TXK2
- HCK2 YES12 PTK62 SRC2 ABL12 BMX2 ABL22 SRMS2
- BTK2
18/64 SIMAP similar genes for FYN using alignment to 18 protein entries: FYN_HUMAN (see all proteins)
(see all similar genes):SRC NCK1 HCK NCK2 YES1 BLK
LYN LCK ABL1 FRK EPHA2 ITSN2
EPHA3 EPHA4 FGR EPHA6 EPHA5 TXK
FYN for paralogs About GeneDecksing
|
Genomic Variants
for FYN gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FYN (111981535 - 112194655 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for FYN
1 CNV: 8527
3 Indels: 81548 93961 93960 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FYN |
|
Disorders
/ Diseases
for FYN gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FYN for disorders About GeneDecksing
OMIM gene information: 137025
OMIM disorders: --
20/69  diseases for FYN (see all 69): About MalaCardsestrogen-receptor negative breast cancer wiskott-aldrich syndrome human t-cell leukemia virus type 1 cleft lip/palate
focal segmental glomerulosclerosis cleft lip lymphopenia systemic lupus erythematosus
alexia lupus erythematosus hepatitis e alcohol dependence
glomerulosclerosis hepatitis c prion disease kaposi's sarcoma
lymphoproliferative syndrome proteinuria brain ischemia fibrosarcoma
2 diseases from the University of Copenhagen DISEASES database for FYN:Cancer Alzheimer's disease 10/33 Novoseek disease relationships for FYN gene (see all 33) About this table
Genetic Association Database (GAD): FYN
Human Genome Epidemiology (HuGE) Navigator: FYN (26 documents)
Tumor Gene Database (TGDB): FYN
Export disorders for FYN gene to outside databases
|
Publications
for FYN gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FYN gene, integrated from 9 sources (see all 902):
(articles sorted by number of sources associating them with FYN) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family. (PubMed id 3526330)1, 2, 3 Semba K.... Toyoshima K. (1986)
- p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn. (PubMed id 12788081)1, 2, 9 Taniguchi S....Yamamoto T. (2003)
- In vivo phosphorylation and membrane association of the fyn proto- oncogene product in IM-9 human lymphoblasts. (PubMed id 1699196)1, 2, 9 Peters D.J.... Laudano A.P. (1990)
- Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125. (PubMed id 11162638)1, 2, 9 Nakamura T....Nakamura S. (2001)
- Fyn phosphorylates human MAP-2c on tyrosine 67. (PubMed id 15536091)1, 2, 9 Zamora-Leon S.P....Shafit-Zagardo B. (2005)
- Regulation of TRPC6 channel activity by tyrosine phosphorylation. (PubMed id 14761972)1, 2, 9 Hisatsune C....Mikoshiba K. (2004)
- Mutation and association analysis of the Fyn kinase gene with alcoholism and schizophrenia. (PubMed id 11121167)1, 4, 9 Ishiguro H....Arinami T. (2000)
- Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity. (PubMed id 10498895)1, 2, 9 Choi S. and Park S. (1999)
- [Analysis of the fyn kinase gene in Alzheimer's disease and schizophrenia] (PubMed id 15098360)1, 4, 9 Nakano Y....Nanko S. (2004)
- Regulation of ultraviolet B-induced phosphorylation of histone H3 at serine 10 by Fyn kinase. (PubMed id 15537652)1, 2, 9 He Z....Dong Z. (2005)
|
External Searches for FYN gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FYN gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FYN gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FYN gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for FYN gene:
Search GeneIP for patents involving FYN
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FYN gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for FYN | | OriGene shRNA RFP for FYN | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FYN | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FYN | | | OriGene Protein Over-expression Lysate for FYN | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FYN | | OriGene 3'-UTR Clone for FYN | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FYN | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FYN | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FYN | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FYN | | OriGene Custom Protein Services for FYN | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FYN | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FYN | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FYN | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FYN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FYN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FYN |
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| | Antibodies & Assays for FYN |
| | | | Tocris compounds for FYN |
| |  |  |  |  | | | | | | Recombinant Protein for FYN |
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 | | | FYN Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FYN |
|  |  |  | | | | ThermoFisher Antibody for FYN |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FYN |
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