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FYN Gene

protein-coding   GIFtS: 76
GCID: GC06M111981

FYN Oncogene Related To SRC, FGR, YES

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FYN Oncogene Related To SRC, FGR, YES1 2     OKT3-Induced Calcium Influx Regulator2
Proto-Oncogene C-Fyn2 3     p59-FYN2
Proto-Oncogene Syn2 3     Src/Yes-Related Novel2
Src-Like Kinase2 3     Tyrosine Kinase P59fyn(T)2
SLK2 3     Tyrosine-Protein Kinase Fyn2
EC 2.7.10.23 8     p59-Fyn3
SYN2     EC 2.7.108
C-Syn Protooncogene2     

External Ids:    HGNC: 40371   Entrez Gene: 25342   Ensembl: ENSG000000108107   OMIM: 1370255   UniProtKB: P062413   

Export aliases for FYN gene to outside databases

Previous GC identifers: GC06M111817 GC06M112005 GC06M112028 GC06M112089 GC06M109555


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FYN Gene:
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine
kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of
phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript
variants encoding distinct isoforms exist. (provided by RefSeq, Jul 2008)

GeneCards Summary for FYN Gene:
FYN (FYN oncogene related to SRC, FGR, YES) is a protein-coding gene. Diseases associated with FYN include alexia, and lymphopenia. GO annotations related to this gene include ion channel binding and identical protein binding. An important paralog of this gene is FRK.

UniProtKB/Swiss-Prot: FYN_HUMAN, P06241
Function: Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation
of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility,
immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic
domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1
phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and
motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal
remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated
proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic
cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit
diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm
components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a
multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases
implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream
signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR)
stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1,
thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and
FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1

summary for FYN Gene:
Src kinases consist of eight non-receptor tyrosine kinases (Src, Fyn, Yes, Lck, Lyn, Hck, Fgr and Blk) that
interact with the intracellular domains of growth factor/cytokine receptors, GPCRs and integrins. Members of
the Src kinase family have a very similar domain structure with a high degree of homology in the SH1
(catalytic), linker, SH2 (p-Tyr binding), SH3 (protein-protein interaction) and SH4 (membrane association)
domains. c-Src, Fyn and Yes are ubiquitously expressed, although high levels of c-Src are found in
platelets, neural tissue and osteoclasts. For c-Src, autophosphorylation of Tyr418 and dephosphorylation of
Tyr530 is required to switch the kinase from the inactive closed formation to the active open formation.
c-Src can be inactivated by two kinases, c-Src kinase (CSK) and CSK homologous kinase (CHK), both of which
phosphorylate Tyr530 of c-Src. The activity of the Src kinase family can also be regulated by phosphatases
(e.g. SHP1), binding to adaptor proteins (e.g. Cbp) and proteasomal degradation. Src kinases are key
upstream mediators of both the PI 3-K and MAPK signaling pathways, and have been shown to have important
roles in cell proliferation, migration and survival.

Gene Wiki entry for FYN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FYN gene promoter:
         AP-1   ATF-2   STAT5A   c-Jun   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): FYN promoter sequence
   Search Chromatin IP Primers for FYN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FYN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

FYN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FYN gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M111981:  view genomic region     (about GC identifiers)

Start:
111,981,535 bp from pter      End:
112,194,655 bp from pter
Size:
213,121 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FYN_HUMAN, P06241 (See protein sequence)
Recommended Name: Tyrosine-protein kinase Fyn  
Size: 537 amino acids; 60762 Da
Cofactor: Manganese
Subunit: Interacts (via its SH3 domain) with PIK3R1 and PRMT8. Interacts with FYB, PAG1, and SH2D1A. Interacts
with CD79A (tyrosine-phosphorylated form); the interaction increases FYN activity. Interacts (via SH2 domain)
with CSF1R (tyrosine phosphorylated) (By similarity). Interacts with TOM1L1 (phosphorylated form). Interacts with
KDR (tyrosine phosphorylated). Interacts (via SH3 domain) with KLHL2 (via N-terminus) (By similarity). Interacts
with SH2D1A and SLAMF1. Interacts (via its SH3 domain) with HEV ORF3 protein. Interacts with ITCH; the
interaction phosphorylates ITCH and negatively regulates its activity. Interacts with FASLG. Interacts with
RUNX3. Interacts with KIT. Interacts with EPHA8; possible downstream effector of EPHA8 in regulation of cell
adhesion. Interacts with PTK2/FAK1; this interaction leads to PTK2/FAK1 phosphorylation and activation. Interacts
with CAV1; this interaction couples integrins to the Ras-ERK pathway
Selected PDB 3D structures from and Proteopedia for FYN (see all 21):
1A0N (3D)        1AOT (3D)        1AOU (3D)        1AVZ (3D)        1AZG (3D)        1EFN (3D)    
Secondary accessions: B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7
Alternative splicing: 3 isoforms:  P06241-1   P06241-2   P06241-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FYN: NX_P06241

Explore proteomics data for FYN at MOPED

Post-translational modifications: 

  • Autophosphorylated at Tyr-420. Phosphorylation on the C-terminal tail at Tyr-531 by CSK maintains the enzyme in an
    inactive state (By similarity). PTPRC/CD45 dephosphorylates Tyr-531 leading to activation. ultraviolet B (UVB)
    strongly increase phosphorylation at Thr-12 and kinase activity, and promotes translocation from the cytoplasm to
    the nucleus. Dephosphorylation at Tyr-420 by PTPN2 negatively regulates T-cell receptor signaling1
  • Palmitoylation at Cys-3 and Cys-6 regulates subcellular location (By similarity)1
  • Ubiquitination2 at Lys182, Lys405, Lys431
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FYN (P06241) (see all 41)
     DNGGYYI  KWTAPEA  FLEDYFT  FLIRESE 


    See FYN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_002028.1  NP_694592.1  NP_694593.1  

    ENSEMBL proteins: 
     ENSP00000357671   ENSP00000346671   ENSP00000229471   ENSP00000357656   ENSP00000357667  
     ENSP00000427993   ENSP00000429294   ENSP00000429866   ENSP00000428695   ENSP00000430364  
     ENSP00000428493   ENSP00000429992   ENSP00000429813   ENSP00000428045   ENSP00000428983  
     ENSP00000428042   ENSP00000429590   ENSP00000430455   ENSP00000229470   ENSP00000348295  
     ENSP00000440646  
    Reactome Protein details: P06241

    FYN Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant FYN Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for FYN
    OriGene Purified Proteins for FYN
    OriGene Protein Over-expression Lysate for FYN
    OriGene MassSpec for FYN
    OriGene Custom Protein Services for FYN
    GenScript Custom Purified and Recombinant Proteins Services for FYN
    Novus Biologicals FYN Proteins
    Novus Biologicals FYN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for FYN
    Cloud-Clone Corp. Proteins for FYN

    FYN Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FYN
    R&D Systems Antibodies for FYN
    Cell Signaling Technology (CST) Antibodies for FYN 
    OriGene Antibodies for FYN
    OriGene Custom Antibody Services for FYN
    Novus Biologicals FYN Antibodies
    Abcam antibodies for FYN
    Cloud-Clone Corp. Antibodies for FYN
    ThermoFisher Antibody for FYN
    LSBio Antibodies in human, mouse, rat for FYN

    FYN Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FYN
    R&D Systems Proteome Profiler Antibody Arrays for FYN
    GenScript FYN-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FYN
    Cloud-Clone Corp. CLIAs for FYN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: FYN oncogene related to SRC, FGR, YES
    Src family

    Selected InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR001452 SH3_domain
     IPR000719 Prot_kinase_dom
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P06241

    ProtoNet protein and cluster: P06241

    3 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: FYN_HUMAN, P06241
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    FYN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FYN_HUMAN, P06241
    Function: Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation
    of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility,
    immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic
    domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1
    phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and
    motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal
    remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated
    proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic
    cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit
    diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm
    components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a
    multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases
    implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream
    signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR)
    stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1,
    thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and
    FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by
    dephosphorylation of this site

         Genatlas biochemistry entry for FYN:
    SRC/YES-related oncogene homolog,involved in T cell signaling regulation,STAR (signal transduction and activator
    of RNA) family

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding IPI16831868
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity TAS--
    GO:0004715non-membrane spanning protein tyrosine kinase activity NAS7822789
    GO:0005102receptor binding ----
         
    FYN for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for FYN:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased colony dispersion (i 

         14 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Fyn):
     behavior/neurological  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  mortality/aging  nervous system  no phenotypic analysis 
     renal/urinary system  reproductive system  taste/olfaction  vision/eye 

    FYN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FYN: Fyntm1Sor Fyntm1Rmp Fyntm1Fam

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FYN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FYN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FYN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FYN

    miRNA
    Products:
        
    miRTarBase miRNAs that target FYN:
    hsa-mir-128-3p (MIRT022048), hsa-mir-93-3p (MIRT038910)

    Block miRNA regulation of human, mouse, rat FYN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FYN (see all 11):
    hsa-miR-429 hsa-miR-125a-3p hsa-miR-4251 hsa-miR-586 hsa-miR-1271 hsa-miR-583 hsa-miR-200c hsa-miR-369-3p
    SwitchGear 3'UTR luciferase reporter plasmidFYN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FYN
    Predesigned siRNA for gene silencing in human, mouse, rat FYN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FYN

    Clone
    Products:
         
    OriGene clones in human, mouse for FYN (see all 18)
    OriGene ORF clones in mouse, rat for FYN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FYN (NM_153047)
    Sino Biological Human cDNA Clone for FYN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FYN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FYN

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FYN
    Browse ESI BIO Cell Lines and PureStem Progenitors for FYN 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FYN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FYN_HUMAN, P06241: Cytoplasm. Nucleus. Cell membrane. Note=Present and active in lipid rafts. Palmitoylation is
    crucial for proper trafficking
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol4
    endosome4
    cytoskeleton2
    extracellular2
    mitochondrion2

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion IEA--
    GO:0005768endosome IDA15611048
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA12150984

    FYN for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FYN About   (see all 97)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    Cytoskeleton remodeling Slit Robo signaling0.92
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    Pathogenic Escherichia coli infection0.43
    2Immune response Fc epsilon RI pathway
    Fc epsilon RI signaling pathway0.41
    Fc-epsilon receptor I signaling in mast cells0.34
    VEGF - VEGF R2 Signaling Pathways0.35
    3CD28 co-stimulation
    CD28 co-stimulation0.66
    GPVI-mediated activation cascade0.31
    CD28 dependent PI3K/Akt signaling0.66
    CTLA4 Signaling0.30
    Costimulation by the CD28 family0.44
    CD28 dependent Vav1 pathway0.00
    CTLA4 inhibitory signaling0.32
    4Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    Focal Adhesion0.65
    5Prolactin Signaling Pathway
    Development Prolactin receptor signaling0.39
    Leptin signaling pathway0.35
    Prolactin Signaling Pathway0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for FYN
        VEGF - VEGF R2 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FYN (see all 26)
        Calcium Mediated T-Cell Apoptosis
    Remodeling of Adherens Junctions
    Guidance Cues and Growth Cone Motility
    Molecular Mechanisms of Cancer
    Semaphorin Signaling

    2 Cell Signaling Technology (CST) Pathways for FYN
        MAP Kinase Signaling
    Tyrosine Kinases / Adaptors

    Selected GeneGo (Thomson Reuters) Pathways for FYN (see all 16)
        Immune response CD28 signaling
    G-protein signaling Regulation of CDC42 activity
    Chemotaxis CXCR4 signaling pathway
    Development Slit-Robo signaling
    Immune response T cell receptor signaling pathway

    Selected BioSystems Pathways for FYN (see all 41)
        Focal Adhesion
    Integrin-mediated cell adhesion
    BDNF signaling pathway
    Interferon type I
    IL-4 signaling Pathway


    Selected Reactome Pathways for FYN (see all 26)
        Nephrin interactions
    CRMPs in Sema3A signaling
    CD28 dependent Vav1 pathway
    FCGR activation
    Regulation of signaling by CBL


    Selected Kegg Pathways  (Kegg details for FYN) (see all 12):
        Axon guidance
    Osteoclast differentiation
    Focal adhesion
    Adherens junction
    Natural killer cell mediated cytotoxicity


    FYN for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FYN: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Adherens Junctions in human mouse rat
              Focal Adhesions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FYN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FYN (P062411, 2, 3 ENSP000003576564) via UniProtKB, MINT, STRING, and/or I2D (see all 641)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAG1Q9NWQ81, 2, 3, ENSP000002205974EBI-515315,EBI-2828115 MINT-8032868 MINT-8034123 MINT-8034138 MINT-8032853 I2D: score=3 STRING: ENSP00000220597
    BCAR1P569451, 2, 3, ENSP000001623304EBI-515315,EBI-702093 MINT-8030008 MINT-8030023 I2D: score=8 STRING: ENSP00000162330
    SH2D1AO608801, 2, 3, ENSP000003601814EBI-515315,EBI-6983382 MINT-3371929 MINT-3371954 I2D: score=6 STRING: ENSP00000360181
    MED28Q9H2041, 2, 3, ENSP000002373804EBI-515315,EBI-514199 MINT-7041679 I2D: score=4 STRING: ENSP00000237380
    ABL2P426841, 2, 3, ENSP000003565954EBI-515315,EBI-1102694 MINT-8110899 I2D: score=3 STRING: ENSP00000356595
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 39):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0006468protein phosphorylation NAS7822789
    GO:0006816calcium ion transport NAS7822789
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007173epidermal growth factor receptor signaling pathway TAS--

    FYN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for FYN
      Browse compounds at ApexBio 

    Compounds for FYN available from Tocris Bioscience    About this table
    CompoundAction CAS #
    1-Naphthyl PP1Src family kinase inhibitor; also inhibits c-Abl[221243-82-9]
    PP 2 Potent, selective Src family kinase inhibitor [172889-27-9]
    PP 3Negative control for PP 2 (Cat. No. 1407)[5334-30-5]
    BosutinibDual Src-Abl inhibitor; antiproliferative[380843-75-4]
    PP 1 Potent, selective Src family kinase inhibitor [172889-26-8]

    4 HMDB Compounds for FYN    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    Manganesemanganese 7439-96-5--

    2 DrugBank Compounds for FYN    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Dasatinib-- 302962-49-8targetmultitarget17139284 20072833 11752352 17016423
    1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for FYN gene (see all 53)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 89.5 600 9104812 (6), 1465444 (6), 9535867 (4), 10838156 (4) (see all 99)
    phosphotyrosine 73.1 13 7524477 (1), 12654250 (1), 1383216 (1), 11063873 (1) (see all 10)
    herbimycin a 67.6 3 9049148 (1), 7543423 (1), 10871840 (1)
    phosphatidylinositol 65.7 41 10848967 (5), 1465444 (3), 7642581 (2), 1328986 (1) (see all 30)
    4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine 54.1 1 18632659 (1)
    happ 45.2 14 15140940 (4), 16237174 (3)
    threonine 44.2 4 1699196 (1), 17098432 (1), 9155022 (1)
    piceatannol 40.4 2 10528214 (1), 11154209 (1)
    serine 38.7 9 12721299 (1), 17098432 (1), 8413237 (1), 8227079 (1) (see all 7)
    calcium 35.6 26 7621861 (3), 10964479 (2), 8500615 (2), 11776298 (1) (see all 19)



    FYN for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for FYN gene (4 alternative transcripts): 
    NM_002037.5  NM_153047.3  NM_153048.3  NM_001242779.1  

    Unigene Cluster for FYN:

    FYN oncogene related to SRC, FGR, YES
    Hs.390567  [show with all ESTs]
    Unigene Representative Sequence: BX537571
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):
    ENST00000368682(uc003pvh.3 uc003pvi.3) ENST00000354650(uc003pvj.3 uc003pvk.3)
    ENST00000229471(uc010kdy.1) ENST00000368667 ENST00000368678 ENST00000491885
    ENST00000467921 ENST00000471959 ENST00000496864 ENST00000476769 ENST00000495935
    ENST00000467899 ENST00000495927 ENST00000523322 ENST00000462856 ENST00000520518
    ENST00000517419 ENST00000518295
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FYN (see all 11):
    hsa-miR-429 hsa-miR-125a-3p hsa-miR-4251 hsa-miR-586 hsa-miR-1271 hsa-miR-583 hsa-miR-200c hsa-miR-369-3p
    SwitchGear 3'UTR luciferase reporter plasmidFYN 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat FYN
      QuantiFast Probe-based Assays in human, mouse, rat FYN

    Additional mRNA sequence: 

    AB451293.1 AB451426.1 AK056699.1 AY429536.1 BC032496.1 BX537571.1 M14333.1 M14676.1 
    S74774.1 

    22 DOTS entries:

    DT.86843886  DT.95289422  DT.121321013  DT.95132434  DT.75101275  DT.92435837  DT.121320911  DT.100880796 
    DT.121320926  DT.121320948  DT.100687227  DT.100880804  DT.100880805  DT.95264558  DT.100880806  DT.121320940 
    DT.121320982  DT.95131340  DT.100880803  DT.436784  DT.75198251  DT.86800269 

    Selected AceView cDNA sequences (see all 304):

    NM_153047 BQ889903 BI468586 AI493204 BQ224296 AW162423 NM_002037 AK097134 
    BM724842 BM738560 CB161968 AU141939 CB215723 BC032496 AI498268 BI552534 
    AA934796 BU741472 T28525 R39866 AA314371 CB162527 M14333 BE221421 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FYN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTAACAAA
    FYN Expression
    About this image


    FYN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
             Dopamine-releasing cells
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
             Thymus
     
     Eye (Sensory Organs)
             Lens
     
     Neurons
             Dopamine-releasing cells
    FYN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FYN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.390567

    UniProtKB/Swiss-Prot: FYN_HUMAN, P06241
    Tissue specificity: Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic
    lineages, especially T-lymphocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FYN: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FYN gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fyn1 , 5 Fyn proto-oncogene1, 5 92.76(n)1
    98.69(a)1
      10 (20.51 cM)5
    143601  NM_008054.21  NP_032080.21 
     393688555 
    chicken
    (Gallus gallus)
    Aves FYN1 FYN oncogene related to SRC, FGR, YES 85.27(n)
    96.63(a)
      396294  NM_205349.1  NP_990680.1 
    lizard
    (Anolis carolinensis)
    Reptilia FYN6
    FYN oncogene related to SRC, FGR, YES
    99(a)
    1 ↔ 1
    1(192360997-192397398)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC043749.12   -- 82.19(n)    BC043749.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fynb1 FYN oncogene related to SRC, FGR, YES b 74.34(n)
    86.7(a)
      574422  NM_001029969.1  NP_001025140.1 
    worm
    (Caenorhabditis elegans)
    Secernentea src-11 , 3 Expression: vulva, anus, mu_bod,
    pharyngeal muscle, more3
    src-11
    48(a)
    (best of 4)3
    55.63(n)1
    54.51(a)1
      I(1567610-1580076)3
    1717221  NM_058465.51  NP_490866.41 


    ENSEMBL Gene Tree for FYN (if available)
    TreeFam Gene Tree for FYN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FYN gene
    FRK2  LCK2  BLK2  LYN2  FGR2  PTK62  YES12  HCK2  
    ABL12  SRC2  ABL22  SRMS2  
    Selected SIMAP similar genes for FYN using alignment to 17 protein entries:     FYN_HUMAN (see all proteins) (see all similar genes):
    NCK1    HCK    SRC    YES1    NCK2    BLK
    LYN    LCK    ABL1    FRK    EPHA2    ITSN2
    EPHA3    EPHA4    EPHA6    EPHA5    FGR    EPHA7

    FYN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FYN (see all 3995)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0417044
    A lung squamous cell carcinoma sample4--see VAR_0417042 V L mis40--------
    VAR_0417054
    A metastatic melanoma sample4--see VAR_0417052 G R mis40--------
    rs624206101,2
    C,F--111981098(+) CCAGGC/TGTGGA 3 -- ds50012Minor allele frequency- T:0.04NA 122
    rs1865899181,2
    --111981151(+) GTTGTC/TGCTCC 3 -- ds50010--------
    rs1914281641,2
    --111981265(+) GGACAC/TAGTAA 3 -- ds50010--------
    rs1846786471,2
    --111981275(+) AATTCC/TGGTTA 3 -- ds50010--------
    rs94877021,2
    C,H--111981349(+) AATAGC/TTGGTC 3 -- ds50015Minor allele frequency- T:0.00NS EA 600
    rs1895152991,2
    --111981366(+) CTACCC/TTTTCT 3 -- ds50010--------
    rs752887241,2
    C,F--111981374(+) TCTAGA/GGGGAA 3 -- ds50011Minor allele frequency- G:0.02NA 120
    rs1431819071,2
    C--111981412(+) TCTGTC/TATTTG 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for FYN (111981535 - 112194655 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FYN:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662755CNV Deletion23128226
    nsv5444CNV Insertion18451855
    esv271837CNV Insertion20981092
    nsv5445CNV Loss18451855
    esv2752088CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 137025    OMIM disorders: --

    Selected diseases for FYN (see all 62):    
    About MalaCards
    alexia    lymphopenia    wiskott-aldrich syndrome    estrogen-receptor negative breast cancer
    hepatitis e    focal segmental glomerulosclerosis    prion disease    tauopathy
    brain ischemia    cblc    proteinuria    pharyngitis
    fibrosarcoma    myocarditis    human t-cell leukemia virus type 1    alcohol dependence
    hepatitis c    myeloma    conjunctivitis    gout

    2 diseases from the University of Copenhagen DISEASES database for FYN:
    Cancer     Alzheimer's disease

    FYN for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for FYN gene (see all 33)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 49 3 8810341 (1), 10532312 (1), 20484117 (1)
    neurofibrillary tangles 30.4 2 15708437 (2)
    leukemia t-cell 18.8 1 9045636 (1)
    alzheimers disease 13.7 8 15098360 (2), 8388744 (1), 16237174 (1), 15082191 (1) (see all 6)
    atrophy 4.76 2 8562954 (1)
    colon cancer 4.6 1 18805444 (1)
    shock 3.06 1 9155022 (1)
    glioblastoma 2.37 6 15994925 (2), 19690143 (1)
    asthma 2.36 2 17703099 (2)
    lymphoma t-cell 2.14 1 11453661 (1)

    Genetic Association Database (GAD): FYN
    Human Genome Epidemiology (HuGE) Navigator: FYN (26 documents)
    Tumor Gene Database (TGDB): FYN

    Export disorders for FYN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for FYN gene, integrated from 10 sources (see all 929):
    (articles sorted by number of sources associating them with FYN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family. (PubMed id 3526330)1, 2, 3 Semba K.... Toyoshima K. (Proc. Natl. Acad. Sci. U.S.A. 1986)
    2. p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn. (PubMed id 12788081)1, 2, 9 Taniguchi S....Yamamoto T. (Biochem. Biophys. Res. Commun. 2003)
    3. In vivo phosphorylation and membrane association of the fyn proto- oncogene product in IM-9 human lymphoblasts. (PubMed id 1699196)1, 2, 9 Peters D.J.... Laudano A.P. (Oncogene 1990)
    4. Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125. (PubMed id 11162638)1, 2, 9 Nakamura T.... Nakamura S. (Biochem. Biophys. Res. Commun. 2001)
    5. Fyn phosphorylates human MAP-2c on tyrosine 67. (PubMed id 15536091)1, 2, 9 Zamora-Leon S.P.... Shafit-Zagardo B. (J. Biol. Chem. 2005)
    6. Regulation of TRPC6 channel activity by tyrosine phosphorylation. (PubMed id 14761972)1, 2, 9 Hisatsune C.... Mikoshiba K. (J. Biol. Chem. 2004)
    7. Mutation and association analysis of the Fyn kinase gene with alcoholism and schizophrenia. (PubMed id 11121167)1, 4, 9 Ishiguro H....Arinami T. (Am. J. Med. Genet. 2000)
    8. Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity. (PubMed id 10498895)1, 2, 9 Choi S. and Park S. (Oncogene 1999)
    9. Association analysis of tyrosine kinase FYN gene polymorphisms in asthmatic children. (PubMed id 17703099)1, 4, 9 Szczepankiewicz A....Hauser J. (Int. Arch. Allergy Immunol. 2008)
    10. [Analysis of the fyn kinase gene in Alzheimer's disease and schizophrenia]. (PubMed id 15098360)1, 4, 9 Nakano Y....Nanko S. (No To Shinkei 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 2534 HGNC: 4037 AceView: FYN Ensembl:ENSG00000010810 euGenes: HUgn2534
    ECgene: FYN Kegg: 2534 H-InvDB: FYN

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FYN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FYN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FYN gene:
    Search GeneIP for patents involving FYN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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