Aliases for FYCO1 Gene
External Ids for FYCO1 Gene
Previous GeneCards Identifiers for FYCO1 Gene
This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2). [provided by RefSeq, Dec 2011]
GeneCards Summary for FYCO1 Gene
FYCO1 (FYVE And Coiled-Coil Domain Containing 1) is a Protein Coding gene. Diseases associated with FYCO1 include Cataract 18, Autosomal Recessive and Early-Onset Nuclear Cataract. GO annotations related to this gene include nucleotide binding. An important paralog of this gene is RUFY4.
UniProtKB/Swiss-Prot for FYCO1 Gene
May mediate microtubule plus end-directed vesicle transport.