Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FYCO1 Gene

Aliases for FYCO1 Gene

  • FYVE And Coiled-Coil Domain Containing 1 2 3
  • Zinc Finger FYVE Domain-Containing Protein 7 3 4
  • CTRCT18 3 6
  • ZFYVE7 3 4
  • CATC2 3 6
  • FYVE And Coiled-Coil Domain-Containing Protein 1 3
  • RUN And FYVE Domain Containing 3 3
  • RUFY3 3

External Ids for FYCO1 Gene

Previous GeneCards Identifiers for FYCO1 Gene

  • GC03M045200
  • GC03M045778
  • GC03M045919

Summaries for FYCO1 Gene

Entrez Gene Summary for FYCO1 Gene

  • This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2). [provided by RefSeq, Dec 2011]

GeneCards Summary for FYCO1 Gene

FYCO1 (FYVE And Coiled-Coil Domain Containing 1) is a Protein Coding gene. Diseases associated with FYCO1 include cataract 18, autosomal recessive and nuclear cataract. An important paralog of this gene is EEA1.

UniProtKB/Swiss-Prot for FYCO1 Gene

  • May mediate microtubule plus end-directed vesicle transport.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FYCO1 Gene

Genomics for FYCO1 Gene

Regulatory Elements for FYCO1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FYCO1 Gene

Start:
45,917,899 bp from pter
End:
45,995,824 bp from pter
Size:
77,926 bases
Orientation:
Minus strand

Genomic View for FYCO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FYCO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FYCO1 Gene

Proteins for FYCO1 Gene

  • Protein details for FYCO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQS8-FYCO1_HUMAN
    Recommended name:
    FYVE and coiled-coil domain-containing protein 1
    Protein Accession:
    Q9BQS8
    Secondary Accessions:
    • B7ZKT7
    • Q3MJE6
    • Q86T41
    • Q86TB1
    • Q8TEF9
    • Q96IV5
    • Q9H8P9

    Protein attributes for FYCO1 Gene

    Size:
    1478 amino acids
    Molecular mass:
    166983 Da
    Quaternary structure:
    • Can form homodimers. Interacts (via C-terminus) with MAP1LC3B. Interacts with RAB7A; the interaction with RAB7A induces FYCO1 recruitment to late endosomal/lysosomal compartments. Interacts with MAP1LC3B (By similarity).
    SequenceCaution:
    • Sequence=AAH07218.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14559.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB84991.1; Type=Frameshift; Positions=1402; Evidence={ECO:0000305};

    Alternative splice isoforms for FYCO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FYCO1 Gene

Proteomics data for FYCO1 Gene at MOPED

Post-translational modifications for FYCO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FYCO1 Gene

No data available for DME Specific Peptides for FYCO1 Gene

Domains for FYCO1 Gene

Gene Families for FYCO1 Gene

HGNC:
  • ZFYVE :Zinc fingers, FYVE domain containing

Protein Domains for FYCO1 Gene

Suggested Antigen Peptide Sequences for FYCO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQS8

UniProtKB/Swiss-Prot:

FYCO1_HUMAN :
  • Q9BQS8
Domain:
  • Contains 1 GOLD domain.
  • Contains 1 RUN domain.
Similarity:
  • Contains 1 FYVE-type zinc finger.
genes like me logo Genes that share domains with FYCO1: view

Function for FYCO1 Gene

Molecular function for FYCO1 Gene

UniProtKB/Swiss-Prot Function: May mediate microtubule plus end-directed vesicle transport.

Gene Ontology (GO) - Molecular Function for FYCO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0005515 protein binding IPI 20100911
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FYCO1: view
genes like me logo Genes that share phenotypes with FYCO1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FYCO1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FYCO1 Gene

Localization for FYCO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FYCO1 Gene

Cytoplasmic vesicle, autophagosome. Endosome. Lysosome. Note=Localizes to the external but not to the internal membrane of autophagosomes, and upon autophagosome/late endosome/lysosome fusion, it stays on the external surface of autolysosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FYCO1 Gene COMPARTMENTS Subcellular localization image for FYCO1 gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
cytosol 3
nucleus 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FYCO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 20100911
GO:0005770 late endosome IDA 20100911
GO:0005776 autophagic vacuole IDA 20100911
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FYCO1: view

Pathways for FYCO1 Gene

SuperPathways for FYCO1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FYCO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0072383 plus-end-directed vesicle transport along microtubule IMP 20100911
genes like me logo Genes that share ontologies with FYCO1: view

No data available for Pathways by source for FYCO1 Gene

Transcripts for FYCO1 Gene

Unigene Clusters for FYCO1 Gene

FYVE and coiled-coil domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FYCO1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FYCO1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FYCO1 Gene

No ASD Table

Relevant External Links for FYCO1 Gene

GeneLoc Exon Structure for
FYCO1
ECgene alternative splicing isoforms for
FYCO1

Expression for FYCO1 Gene

mRNA expression in normal human tissues for FYCO1 Gene

mRNA differential expression in normal tissues according to GTEx for FYCO1 Gene

This gene is overexpressed in Muscle - Skeletal (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FYCO1 Gene

SOURCE GeneReport for Unigene cluster for FYCO1 Gene Hs.200227

mRNA Expression by UniProt/SwissProt for FYCO1 Gene

Q9BQS8-FYCO1_HUMAN
Tissue specificity: Expressed in heart and skeletal muscle.
genes like me logo Genes that share expressions with FYCO1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FYCO1 Gene

Orthologs for FYCO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FYCO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FYCO1 35
  • 99.44 (n)
  • 99.26 (a)
FYCO1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FYCO1 35
  • 83.53 (n)
  • 80.91 (a)
FYCO1 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FYCO1 35
  • 84.18 (n)
  • 81.34 (a)
FYCO1 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fyco1 35
  • 79.81 (n)
  • 78.2 (a)
Fyco1 16
Fyco1 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FYCO1 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FYCO1 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fyco1 35
  • 80.32 (n)
  • 78.55 (a)
chicken
(Gallus gallus)
Aves FYCO1 35
  • 62.58 (n)
  • 55.68 (a)
FYCO1 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FYCO1 36
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii FYCO1 (2 of 2) 36
  • 38 (a)
OneToMany
fyco1a 36
  • 38 (a)
OneToMany
LOC565649 35
  • 50.62 (n)
  • 39.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4030 36
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rabn-5 36
  • 17 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PIB1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
OneToMany
Species with no ortholog for FYCO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FYCO1 Gene

ENSEMBL:
Gene Tree for FYCO1 (if available)
TreeFam:
Gene Tree for FYCO1 (if available)

Paralogs for FYCO1 Gene

Paralogs for FYCO1 Gene

genes like me logo Genes that share paralogs with FYCO1: view

Variants for FYCO1 Gene

Sequence variations from dbSNP and Humsavar for FYCO1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs7129 -- 45,918,267(-) TGGGG(A/G)GGCAT utr-variant-3-prime, nc-transcript-variant
rs7130 -- 45,918,023(-) CCTGC(A/T)CAATG utr-variant-3-prime, nc-transcript-variant
rs730983 -- 45,986,564(-) GCCCT(C/G)TTTGG intron-variant, upstream-variant-2KB
rs737452 -- 45,985,918(+) AGGTT(A/G)TAATG intron-variant, upstream-variant-2KB
rs751552 -- 45,975,359(+) AGCAG(A/T)TTACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FYCO1 Gene

Variant ID Type Subtype PubMed ID
nsv876734 CNV Gain 21882294
nsv834678 CNV Gain 17160897
nsv876736 CNV Gain 21882294
dgv1453e1 CNV Complex 17122850
esv2725227 CNV Deletion 23290073

Relevant External Links for FYCO1 Gene

HapMap Linkage Disequilibrium report
FYCO1
Human Gene Mutation Database (HGMD)
FYCO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FYCO1 Gene

Disorders for FYCO1 Gene

(1) OMIM Diseases for FYCO1 Gene (607182)

UniProtKB/Swiss-Prot

FYCO1_HUMAN
  • Cataract 18 (CTRCT18) [MIM:610019]: An opacification of the crystalline lens of the eye becoming evident at birth or in infancy. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. {ECO:0000269 PubMed:21636066}. Note=The disease is caused by mutations affecting the gene represented in this entry. Pathogenic mutations in FYCO1 can affect intracellular transport of autophagocytic vesicles from the perinuclear area to the periphery, leading to an accumulation of large numbers of vesicles and hence loss of lens transparency (PubMed:21636066). {ECO:0000269 PubMed:21636066}.

Relevant External Links for FYCO1

Genetic Association Database (GAD)
FYCO1
Human Genome Epidemiology (HuGE) Navigator
FYCO1
genes like me logo Genes that share disorders with FYCO1: view

Publications for FYCO1 Gene

  1. The transcriptional map of the common eliminated region 1 (C3CER1) in 3p21.3. (PMID: 11896456) Kiss H. … Dumanski J.P. (Eur. J. Hum. Genet. 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport. (PMID: 20100911) Pankiv S. … Johansen T. (J. Cell Biol. 2010) 3 4

Products for FYCO1 Gene

Sources for FYCO1 Gene

Back to Top

Content